WO2021168544A1 - Apparatus and method for collecting a breath sample using a container with controllable volume - Google Patents
Apparatus and method for collecting a breath sample using a container with controllable volume Download PDFInfo
- Publication number
- WO2021168544A1 WO2021168544A1 PCT/CA2021/050091 CA2021050091W WO2021168544A1 WO 2021168544 A1 WO2021168544 A1 WO 2021168544A1 CA 2021050091 W CA2021050091 W CA 2021050091W WO 2021168544 A1 WO2021168544 A1 WO 2021168544A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- breath
- container
- volume
- conduit
- piston
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract description 70
- 239000002594 sorbent Substances 0.000 claims description 120
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 84
- 230000008859 change Effects 0.000 claims description 70
- 239000000470 constituent Substances 0.000 claims description 69
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 42
- 239000001569 carbon dioxide Substances 0.000 claims description 42
- 239000012080 ambient air Substances 0.000 description 52
- 239000003570 air Substances 0.000 description 35
- 238000009833 condensation Methods 0.000 description 16
- 230000005494 condensation Effects 0.000 description 16
- 239000000463 material Substances 0.000 description 13
- 239000007789 gas Substances 0.000 description 12
- 230000007423 decrease Effects 0.000 description 11
- 239000003463 adsorbent Substances 0.000 description 10
- 239000012530 fluid Substances 0.000 description 10
- 239000012855 volatile organic compound Substances 0.000 description 7
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 229910052760 oxygen Inorganic materials 0.000 description 6
- 239000001301 oxygen Substances 0.000 description 6
- 239000006260 foam Substances 0.000 description 5
- 229910001220 stainless steel Inorganic materials 0.000 description 5
- 239000010935 stainless steel Substances 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 238000011109 contamination Methods 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 239000004743 Polypropylene Substances 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- -1 polypropylene Polymers 0.000 description 3
- 229920001155 polypropylene Polymers 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 238000001179 sorption measurement Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 238000012864 cross contamination Methods 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000011010 flushing procedure Methods 0.000 description 2
- 210000003127 knee Anatomy 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 230000037452 priming Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000002470 solid-phase micro-extraction Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000003575 carbonaceous material Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000013500 data storage Methods 0.000 description 1
- 238000003795 desorption Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920001973 fluoroelastomer Polymers 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 230000004199 lung function Effects 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000010943 off-gassing Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229920002620 polyvinyl fluoride Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000012858 resilient material Substances 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
- A61B5/0836—Measuring rate of CO2 production
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0096—Casings for storing test samples
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/087—Measuring breath flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/097—Devices for facilitating collection of breath or for directing breath into or through measuring devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B2010/0083—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements for taking gas samples
- A61B2010/0087—Breath samples
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3334—Measuring or controlling the flow rate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/22—Valves or arrangement of valves
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
Definitions
- the specification relates generally to sample collection systems, and more particularly to apparatuses and methods for collecting a breath sample.
- Breath sample collection has traditionally been performed by collecting breath from a patient in a large container. The breath sample is then extracted from the container and transferred directly to an analyzer.
- sorbent tubes are tubes containing a solid adsorbent material having a large surface area.
- some of the constituents such as oxygen and carbon dioxide, flow through and out the other end of the sorbent tube, whereas other constituents are adsorbed by the adsorbent material.
- This enables many of the constituents of a breath sample to be captured by the adsorbent material while allowing the most voluminous constituents to flow through, thereby condensing the breath sample.
- most of the constituents of the breath sample can be collected within a much smaller volume.
- sorbent tubes capture the constituents of breath more effectively at certain flow rates of breath through the sorbent tubes.
- the rate at which breath is flowed through the sorbent tubes in state-of-the-art devices is driven by the rate at which breath is blown into these devices by the person. This leads to a loss of parts of the breath sample.
- an apparatus for collecting a breath sample comprising: a breath input interface configured to receive exhaled breath; a container connected to the breath input interface for storing at least some of the breath; and at least one controller configured to control a flow of the at least some of the breath from the container to at least one sorbent tube connected to the container asynchronous of when the breath is received.
- the container can have a cavity in which the at least some of the breath is stored, a volume of the cavity being controllable.
- the volume of the cavity can be controllable by the at least one controller.
- the container can include a piston chamber that has a piston positioned therein, a position of the piston controlling the volume of the cavity.
- the at least one controller can be configured to actuate the piston to increase the volume of the cavity as the at least some of the exhaled breath is being received.
- the apparatus can further include: a valve intermediate the breath input interface and the container; a first conduit system connecting the breath input interface and the valve; and a second conduit system connecting the container to the at least one sorbent tube.
- the at least one controller can be configured to control the valve to close and control actuation of the piston to impel the at least some of the breath through a subset of the at least one sorbent tube.
- a tube inlet valve can be positioned between the container and each of the at least one sorbent tube.
- the at least one controller can be configured to control each of the at least one tube inlet valve to select the subset of the at least one sorbent tube through which the at least some of the breath is flowed.
- the subset can be a first subset
- the apparatus can further include an inlet valve positioned along the second conduit system between an inlet and the container
- the at least one controller can be configured to open the inlet valve and control actuation of the piston to draw air through the inlet and into the cavity
- the at least one controller can be configured to close the inlet valve and impel the intaken air from the cavity through the second conduit system.
- the at least one controller can control actuation of the piston to impel the intaken air through a second subset of the at least one sorbent tube.
- a tube inlet valve can be positioned between the container and each of the at least one sorbent tube.
- the at least one controller can be configured to control each of the at least one tube inlet valve to select the second subset of the at least one sorbent tube through which the intaken air is flowed through.
- the container can include an at least partially flexible collapsible receptacle.
- the apparatus can further comprise: a valve intermediate the breath input interface and the container; a first conduit system connecting the breath input interface and the valve; and a second conduit system connecting the container to the at least one sorbent tube.
- the apparatus can further include a pump controlled by the at least one controller to impel the at least some of the breath from the container through a subset of the at least one sorbent tube.
- a tube inlet valve can be positioned between the container and each of the at least one sorbent tube.
- the at least one controller can be configured to control each of the at least one tube inlet valve to select the subset of the at least one sorbent tube through which the at least some of the breath is flowed.
- the pump can be positioned between the valve and the container, and the at least one controller can be configured to control the pump to draw the at least some of the exhaled breath into the container.
- the subset can be a first subset
- the apparatus can further include an inlet valve positioned along the second conduit system between an inlet and the container, and the at least one controller can be configured to close the inlet valve and control the pump to flow air from the container through a second subset of the at least one sorbent tube.
- the at least one controller can be configured to open the inlet valve and control the pump to flow air through the inlet and into the cavity.
- a tube inlet valve can be positioned between the container and each of the at least one sorbent tube.
- the at least one controller can be configured to control each of the at least one tube inlet valve to select the first subset of the at least one sorbent tube through which the at least some of the breath is flowed.
- the apparatus can further comprise: a valve intermediate the breath input interface and the container; and a first conduit system connecting the breath input interface and the valve.
- the at least one controller can be configured to control the valve to close and control the volume of the container to impel the at least some of the breath through a subset of the at least one sorbent tube upon capturing a target volume of the breath in the container.
- the at least one controller can be configured to control the volume of the container to decrease at one of at least two breath flow rates at which the at least one controller can control the volume of the container to impel the breath through the subset of the at least one sorbent tube.
- a method of collecting a breath sample comprising: receiving exhaled breath via a breath input interface; storing at least some of the breath in a container connected to the breath input interface; and controlling, via at least one controller, a flow of the at least some of the breath from the container to at least one sorbent tube connected to the container asynchronous of when the exhaled breath is received.
- the storing can comprise storing the at least some of the exhaled breath in a cavity of the container, and a volume of the cavity can be controllable.
- the method can further include controlling the volume of the cavity via the at least one controller.
- the method can further include actuating, via the at least one controller, a piston positioned in a piston chamber of the container, a position of the piston controlling the volume of the cavity.
- the method can further comprise actuating the piston to increase the volume of the cavity as the at least some of the exhaled breath is being received.
- the method can further include controlling a flow of the at least some of the exhaled breath via a valve intermediate the breath input interface and the container, wherein a first conduit system connects the breath input interface and the valve, and wherein a second conduit system connects the container to the at least one sorbent tube.
- the method can further include: controlling the valve via the at least one controller to close; and controlling actuation of the piston to impel the at least some of the breath through a subset of the at least one sorbent tube.
- a tube inlet valve can be positioned between the container and each of the at least one sorbent tube, and the method can further include controlling each of the at least one tube inlet valve to select the subset of the at least one sorbent tube through which the at least some of the breath is flowed.
- the method can further include: controlling, via the at least one controller, the valve to close; controlling an inlet valve separating the container from an inlet to open; controlling actuation of the piston to draw air through the inlet and into the cavity; controlling the inlet valve to close; and controlling actuation of the piston to impel the intaken air from the cavity through the second conduit system.
- the method can further include controlling actuation of the piston to impel the intaken air through a second subset of the at least one sorbent tube.
- a tube inlet valve can be positioned between the container and each of the at least one sorbent tube.
- the method can further include controlling each of the at least one tube inlet valve to select the second subset of the at least one sorbent tube through which the intaken air is flowed through.
- the container can include an at least partially flexible collapsible receptacle.
- the method can further include controlling a flow of the at least some of the breath via a valve intermediate the breath input interface and the container, wherein a first conduit system connects the breath input interface and the valve, and wherein a second conduit system connects the container to the at least one sorbent tube.
- the method can further include controlling a pump to flow the at least some of the breath from the container through a subset of the least one sorbent tube.
- a tube inlet valve can be positioned between the container and each of the at least one sorbent tube.
- the method can further comprise controlling each of the at least one tube inlet valve to select the subset of the at least one sorbent tube through which the at least some of the breath is flowed.
- the pump can be positioned between the valve and the container, and the method can further include controlling the pump to draw the at least some of the exhaled breath into the container.
- the subset can be a first subset, and the method can further include: closing the valve; opening an inlet valve intermediate an inlet and the container; and controlling the pump to flow air through a second subset of the at least one sorbent tube.
- the method can further include: opening the inlet valve; and controlling the pump to flow air through the inlet and into the cavity.
- a tube inlet valve can be positioned between the container and each of the at least one sorbent tube.
- the method can further include controlling each of the at least one tube inlet valve to select the subset of the at least one sorbent tube through which the at least some of the breath is flowed.
- the method can further include controlling a flow of the exhaled breath from a first conduit system to which the breath input interface is connected through to the container via a valve.
- the method can further include: controlling the valve to close; and controlling the volume of the container to flow the at least some of the breath through a subset of the at least one sorbent tube upon capturing a target volume of the breath in the container.
- the volume can be controlled to decrease at one of at least two breath flow rates at which the volume can be controlled to decrease at to impel the breath through the subset of the at least one sorbent tube.
- an apparatus for collecting a breath sample comprising: a breath input interface configured to receive exhaled breath; a metering device configured to determine a constituent level in the breath being received; a first conduit system extending from the breath input interface and connected to at least one breath sample storage device; a valve positioned along the first conduit system to control a flow of the exhaled breath towards the at least one breath sample storage device; and at least one controller configured to determine if the constituent level is within a constituent level target range, determine if a change rate in the constituent level is within a constituent level change rate target range, and control the valve to open at least partially based on whether the constituent level is within the constituent level target range and the change rate is within the constituent level change rate target range.
- the metering device can be a capnometer, the constituent level can be a carbon dioxide level, the constituent level target range can be a carbon dioxide level target range, and the constituent level change rate target range can be a carbon dioxide level change rate target range.
- the apparatus can further include a flow meter configured to determine a flow rate of the exhaled breath being received, wherein the at least one controller is configured to control the valve to open at least partially based on the determined flow rate being within a flow rate target range.
- the apparatus can further include a display, wherein the at least one controller is configured to control the display to present flow rate notifications thereon.
- the apparatus can further include at least one light element, wherein the at least one controller is configured to control the at least one light element to present flow rate notifications therewith.
- the apparatus can further include a speaker, wherein the at least one controller is configured to control the speaker to play audible flow rate notifications therethrough.
- the constituent level target range can extend between a constituent level minimum threshold and an infinite upper bound.
- the constituent level change rate target range can extend between an infinite lower bound and a constituent level change rate maximum threshold.
- the flow rate target range can extend between a minimum flow rate threshold and an infinite upper bound.
- the at least one controller can be configured to monitor the constituent level after opening the valve.
- the apparatus can further include a flow meter configured to determine a flow rate of the exhaled breath being received, wherein the at least one controller is configured to monitor the flow rate after opening the valve, and control the valve to close at least partially based on the determined flow rate being within a flow rate termination range.
- a method for collecting a breath sample comprising: receiving exhaled breath via a breath input interface from which a first conduit system extends towards at least one breath sample storage device, wherein a valve is positioned to control travel of the exhaled breath from the first conduit system towards the at least one breath sample storage device; determining, via at least one controller, if a constituent level in the exhaled breath being received is within a constituent level target range; determining a change rate in the constituent level is within a constituent level change rate target range; and controlling the valve to open at least partially based on whether the constituent level is within the constituent level target range and the change rate is within the constituent level change rate target range.
- the constituent level can be a carbon dioxide level
- the constituent level target range can be a carbon dioxide level target range
- the constituent level change rate target range can be a carbon dioxide level change rate target range.
- the method can further include determining a flow rate of the exhaled breath being received, wherein the capturing is performed at least partially based on the determined flow rate being within a flow rate target range.
- the method can further include controlling a display to present flow rate notifications thereon.
- the method can further include controlling at least one light element to present flow rate notifications therewith.
- the method can further include control a speaker to play audible flow rate notifications therethrough.
- the carbon dioxide level target range can extend between a carbon dioxide level minimum threshold and an infinite upper bound.
- the carbon dioxide level change rate target range can extend between an infinite lower bound and a carbon dioxide level change rate maximum threshold.
- the flow rate target range can extend between a minimum flow rate threshold and an infinite upper bound.
- the method can further include monitoring the carbon dioxide level after opening the valve.
- the method can further include determining a flow rate of the exhaled breath being received, wherein the at least one controller is configured to monitor the flow rate after opening the valve, and control the valve to close at least partially based on the determined flow rate being within a flow rate termination range.
- an apparatus for collecting a breath sample comprising: a breath input interface configured to receive exhaled breath; a first conduit system connected to the breath input interface; a valve configured to control fluid communication between the first conduit system and at least one breath sample storage device configured to store a breath sample; an air circulation system configured to circulate air through the first conduit system upon completion of a first received exhaled breath; and at least one controller configured to control the valve upon completion of the first received exhaled breath at least partially based on a humidity level in the first conduit system.
- the at least one controller can be configured to control the valve at least partially based on whether a change rate in the humidity level is within a humidity level change rate target range.
- the at least one controller can be configured to close the valve to inhibit passage of a subsequent exhaled breath from the first conduit system to the at least one breath sample storage device until the change rate in the humidity level within the first conduit system is within the humidity level change rate target range.
- the apparatus can further include a hygrometer connected to the first conduit system and configured to determine the humidity level in the first conduit system.
- the apparatus can further include a notification system for indicating when the change rate in the humidity level within the first conduit system is within the humidity level change rate target range.
- the first conduit system can include a breath intake conduit extending between the breath input interface and the valve, and the hygrometer can be connected to an exhaust conduit of the first conduit system that branches from the breath intake conduit.
- the fluid circulation system can be directly connected to the exhaust conduit.
- the exhaust conduit can include a flow meter configured to measure a flow rate along the exhaust conduit.
- the at least one controller can be configured to control the valve at least partially based on whether the humidity level is within a humidity level target range.
- the at least one controller can be configured to close the valve to inhibit passage of a subsequent exhaled breath from the first conduit system to the at least one breath sample storage device until the humidity level within the first conduit system is within the humidity level target range.
- a method for collecting a breath sample comprising: receiving an exhaled breath via a breath input interface connected to a first conduit system; collecting at least some of the exhaled breath via at least one breath sample storage device connected to the first conduit system; detecting a completion of the exhaled breath; closing a valve between the first conduit system and the at least one sorbent tube upon detecting the completion of the exhaled breath; circulating air through a first conduit system connected to the breath input interface after detecting the completion of the exhaled breath; monitoring a humidity level in the first conduit system; and controlling, via at least one controller, the valve at least partially based on the humidity level in the first conduit system.
- the controlling can include determining if a change rate in the humidity level is within a humidity level change rate target range.
- the method can further include controlling the valve to close to inhibit passage of a subsequently exhaled breath from the first conduit system to the at least one breath sample storage device until the change rate in the humidity level within the first conduit system is within the humidity level change rate target range.
- the method can further include determining the humidity level in the first conduit system via a hygrometer connected to the first conduit system.
- the method can further include indicating when the change rate in the humidity level is within the humidity level change rate target range.
- the first conduit system can include a breath intake conduit extending between the breath input interface and the valve, and wherein the determining of the humidity level is performed by a hygrometer connected to an exhaust conduit of the first conduit system that branches from the breath intake conduit.
- the fluid circulation system can be directly connected to the exhaust conduit.
- the method can further include measuring a flow rate along the exhaust conduit via a flow meter along the exhaust conduit.
- the controlling can include determining if the humidity level is within a humidity level target range.
- the method can further include controlling the valve to close to inhibit passage of a subsequently exhaled breath from the first conduit system to the at least one breath sample storage device until the humidity level within the first conduit system is within the humidity level target range.
- an apparatus for collecting a breath sample comprising: a breath input interface configured to receive exhaled breath; a first conduit system connected to the breath input interface; at least one breath sample storage device connected to the breath input interface via a breath intake conduit of the first conduit system extending between the breath input interface and the breath collection system, the at least one breath sample storage device being configured to capture at least some of the breath; and at least one metering device for measuring at least one characteristic, the at least one metering device being positioned along an exhaust conduit of the first conduit system that branches from the breath intake conduit.
- the at least one metering device can include a flow meter that measures a flow rate of the exhaled breath along the exhaust conduit of the first conduit system.
- the at least one metering device can include a capnometer positioned along the exhaust conduit of the first conduit system to measure a carbon dioxide level in the exhaled breath.
- the at least one metering device can include a hygrometer positioned along the exhaust conduit of the first conduit system to measure a humidity level in the exhaled conduit.
- the apparatus can further include a pump positioned along the exhaust conduit of the first conduit system to flow air through the exhaust conduit.
- a method for collecting a breath sample comprising: receiving exhaled breath via a breath input interface; a first conduit system connected to the breath input interface; capturing breath via a breath collection system that is connected to the breath input interface via a breath intake conduit of a first conduit system extending between the breath input interface and the breath collection system; and measuring at least one characteristic along an exhaust conduit of the first conduit system that branches from the breath intake conduit via at least one metering device positioned along the exhaust conduit.
- the at least one metering device can include a flow meter, and the at least one characteristic can include a flow rate of the exhaled breath along the exhaust conduit.
- the at least one metering device can include a capnometer, and the at least one characteristic can include a carbon dioxide level of the exhaled breath.
- the method can further include determining a humidity level along the exhaust conduit via a hygrometer positioned along the exhaust conduit of the first conduit system.
- the method can further include flowing air through the exhaust conduit via a pump positioned along the exhaust conduit.
- an apparatus for collecting a breath sample comprising: a breath input interface configured to receive exhaled breath; a container connected to the breath input interface for receiving at least some of the exhaled breath, the container having a cavity with a volume that is controllable; and at least one controller configured to control the volume of the cavity to increase at a volume increase rate that is at most equal to a flow rate of the exhaled breath received by the breath input interface.
- a breath intake conduit of a first conduit system can extend from the breath input interface and towards the container, and an exhaust conduit of the first conduit system can branch from the breath collecting portion at a first end thereof and has an outlet at a second end thereof.
- the apparatus can further include a flow meter positioned to measure a flow rate along the exhaust conduit.
- the volume increase rate of the volume of the container can be proportional to the flow rate along the exhaust conduit.
- the volume of the container can be directly mechanically controllable by the at least one controller.
- the container can include a piston chamber having an actuatable piston positioned therein, a position of the piston in the piston chamber defining the volume of a cavity.
- the apparatus can further include a valve positioned to control travel of the exhaled breath to the piston chamber.
- the apparatus can further include at least one sorbent tube connected to the container, wherein the at least one controller is configured to control the valve to close and control actuation of the piston to impel the breath in the cavity through the at least one sorbent tube.
- the container can include an at least partially flexible collapsible receptacle, and the apparatus can further include a pump configured intermediate the breath input interface and the container to impel the breath into the at least partially flexible collapsible receptacle at the volume increase rate.
- the apparatus can further include at least one sorbent tube connected to the at least partially flexible collapsible receptacle, wherein the at least one controller is configured to control the pump to impel the breath in the cavity through a subset of the at least one sorbent tube.
- the apparatus can further include a valve positioned to control travel of the exhaled breath to the piston chamber.
- the apparatus can further include a valve positioned to control travel of the exhaled breath to the piston chamber.
- the apparatus can further include a metering device positioned to determine a constituent level in the exhaust conduit, and the at least one controller can be configured to determine if the constituent level is within a constituent level target range, determine if a change rate in the constituent level is within a constituent level change rate target range, and control the valve to open at least partially based on whether the constituent level is within the constituent level target range and the change rate is within the constituent level change rate target range.
- the metering device can be a capnometer, the constituent level can be a carbon dioxide level, the constituent level target range can be a carbon dioxide level target range, and the constituent level change rate target range can be a carbon dioxide level change rate target range.
- the apparatus can further include: a breath intake conduit of a first conduit system extending from the breath input interface and towards the container; and a flow meter positioned to measure a flow rate of the exhaled breath along the breath intake conduit.
- the volume increase rate of the volume of the container can be proportional to the flow rate along the breath intake conduit.
- the volume of the container can be directly mechanically controllable by the at least one controller.
- the container can include a piston chamber having an actuatable piston positioned therein, a position of the piston in the piston chamber defining the volume of a cavity.
- the apparatus can further include a valve positioned to control travel of the exhaled breath to the piston chamber.
- the apparatus can further include at least one sorbent tube connected to the container, wherein the at least one controller is configured to control the valve to close and control actuation of the piston to impel the breath in the cavity through a subset of the at least one sorbent tube.
- the container can include an at least partially flexible collapsible receptacle
- the apparatus can further include a pump configured intermediate the breath input interface and the container to impel the breath into the at least partially flexible collapsible receptacle at the volume increase rate.
- a method for collecting a breath sample comprising: receiving exhaled breath via a breath input interface; storing at least some of the exhaled breath in a container connected to the breath input interface, the container having a cavity with a volume that is controllable; and controlling, via at least one controller, the volume of the container to increase at a volume increase rate that is at most equal to a flow rate of the exhaled breath received by the breath input interface.
- a breath intake conduit of a first conduit system can extend from the breath input interface and towards the container, and an exhaust conduit of the first conduit system can branch from the breath collecting portion at a first end thereof and has an outlet at a second end thereof.
- the method can further include measuring a flow rate along the exhaust conduit via a flow meter.
- the volume increase rate of the volume of the container can be proportional to the flow rate.
- the method can further include directly mechanically controlling the volume of the container.
- the container can include a piston chamber in which a piston is positioned, the position of the piston defining the volume of a cavity, and wherein the directly mechanically controlling comprises actuating the piston.
- the method can further include travel of the exhaled breath to the piston chamber via a valve positioned between the breath input interface and the container.
- the method can further include: controlling the valve to close; and controlling actuation of the piston to impel the breath in the cavity through at least one sorbent tube connected to the container.
- the container can include an at least partially flexible collapsible receptacle, and the method can further include impelling, via a pump intermediate the breath input interface and the container, the exhaled breath into the at least partially flexible collapsible receptacle at the volume increase rate.
- the method can further include controlling the pump to impel the breath in the cavity through a subset of at least one sorbent tube connected to the at least partially flexible collapsible receptacle.
- the method can further include controlling travel of the exhaled breath to the piston chamber via a valve.
- the method can further include controlling travel of the exhaled breath to the piston chamber via a valve.
- the method can further include: determining a constituent level in the exhaust conduit; comparing, via the at least one controller, the constituent level to a constituent level target range; comparing a change rate in the constituent level to a constituent level change rate target range; and control the valve to open at least partially based on whether the constituent level is within the constituent level target range and whether the change rate is within the constituent level change rate target range.
- the constituent level can be a carbon dioxide level
- the constituent level target range can be a carbon dioxide level target range
- the constituent level change rate target range can be a carbon dioxide level change rate target range.
- a breath intake conduit of a first conduit system can extend from the breath input interface and towards the container, and the method can further include measuring a flow rate of the exhaled breath along the breath intake conduit via a flow meter.
- the volume increase rate of the volume of the container can be proportional to the flow rate.
- the method can further include directly mechanically controlling the volume of the container by the at least one controller.
- the container can include a piston chamber having an actuatable piston positioned therein, and the method can further include actuating a position of the piston in the piston chamber defining the volume of a cavity.
- the method can further include controlling travel of the exhaled breath to the piston chamber via a valve.
- the method can further include: controlling the valve to close; and controlling actuation of the piston to impel the breath in the cavity through a subset of at least one sorbent tube connected to the container.
- the container can include an at least partially flexible collapsible receptacle, and the method can further include impelling the breath into the at least partially flexible collapsible receptacle at the volume increase rate via a pump positioned intermediate the breath input interface and the container.
- FIG. 1 shows a breath sample collection apparatus in accordance with one embodiment thereof
- FIG. 2 shows a schematic diagram showing a sorbent tube for use with the apparatus of FIG. 1;
- FIG. 3 is a flowchart of the general method of collecting breath using the apparatus of FIG. 1;
- FIG. 4A shows the breath sample collection apparatus of FIG. 1 , wherein ambient air is being drawn in to a piston chamber
- FIG. 4B shows the breath sample collection apparatus of FIG. 4A during flushing of the apparatus with the ambient air
- FIG. 4C shows sorbent tubes fitted in the breath sample collection apparatus of FIG. 4A and ambient air being drawn into the container;
- FIG. 4D shows the ambient air being impelled through one of the sorbent tubes in the breath sample collection apparatus of FIG. 4A;
- FIG. 4E shows the breath sample collection apparatus of FIG. 4A as a person commences to breathe into the breath sample collection apparatus
- FIG. 4F shows the breath sample collection apparatus of FIG. 4C collecting a breath sample after the breath is determined to be alveolar
- FIG. 4G shows the breath sample collection apparatus of FIG. 4C being used to prime the breath sample collection apparatus
- FIG. 4H shows the breath sample collection apparatus of FIG. 4C collecting a breath sample after sorbent tubes have been loaded
- FIG. 4I shows the breath sample collection apparatus of FIG. 4C flowing the collected breath sample through one of the sorbent tubes
- FIG. 5 shows a graph of the carbon dioxide level in breath over time during a breath
- FIG. 6 shows the humidity level in the breath sample collection apparatus while the humidity is being removed by the pump
- FIG. 7A shows an apparatus for collecting a breath sample including a collapsed bag and its operating environment in accordance with another embodiment
- FIG. 7B shows the apparatus of FIG. 7A, wherein the bag is expanded
- FIG. 8 shows a breath sample collection apparatus in accordance with a further embodiment.
- Any module, unit, component, server, computer, terminal, engine or device exemplified herein that executes instructions may include or otherwise have access to computer readable media such as storage media, computer storage media, or data storage devices (removable and/or non-removable) such as, for example, magnetic disks, optical disks, or tape.
- Computer storage media may include volatile and non-volatile, removable and non-removable media implemented in any method or technology for storage of information, such as computer readable instructions, data structures, program modules, or other data.
- Examples of computer storage media include RAM, ROM, EEPROM, flash memory or other memory technology, CD-ROM, digital versatile disks (DVD) or other optical storage, magnetic cassettes, magnetic tape, magnetic disk storage or other magnetic storage devices, or any other medium which can be used to store the desired information and which can be accessed by an application, module, or both. Any such computer storage media may be part of the device or accessible or connectable thereto.
- any processor or controller set out herein may be implemented as a singular processor or as a plurality of processors. The plurality of processors may be arrayed or distributed, and any processing function referred to herein may be carried out by one or by a plurality of processors, even though a single processor may be exemplified. Any method, application or module herein described may be implemented using computer readable/executable instructions that may be stored or otherwise held by such computer readable media and executed by the one or more processors.
- a breath sample collection apparatus 20 in accordance with an embodiment is shown in FIG. 1.
- the breath sample collection apparatus 20 enables a breath sample to be collected in sorbent tubes asynchronously of when exhaled breath is provided.
- the breath sample collection apparatus 20 includes a container for receiving exhaled breath.
- the breath is subsequently flowed through one or more sorbent tubes asynchronously of when the breath is received.
- the flowing of the breath through the one or more sorbent tubes can be performed by generating a positive relative pressure difference to impel the breath, by generating a negative relative pressure difference to draw the breath, or in any other suitable manner.
- the adsorption of the breath by the sorbent tubes can be controlled more stringently.
- the breath sample collection apparatus 20 includes a breath input interface 24 for receiving exhaled breath from a person.
- the breath input interface 24 includes a mouthpiece 36 that is secured to a breath intake end 40 of a breath intake conduit 44 of a pre-collection conduit system 46.
- the mouthpiece 36 is made of polypropylene or another suitably safe material that is preferably inexpensive so that it can be disposable/replaced. Further, preferably, the mouthpiece 36 does not off-gas volatile organic compounds (“VOCs”) or off-gases VOCs at a low rate so that it does not significantly contaminate the breath sample. It can include a viral/bacterial filter to keep bacterium and particulates out of the sample. By making the mouthpiece 36 disposable, each patient can be provide with a new filter to avoid cross contamination of the samples and passing on of viruses, bacteria, etc.
- VOCs off-gas volatile organic compounds
- the polypropylene of the mouthpiece 36 is clear and will slightly fog up if humidity is high. This feature can be used to visibly detect condensation, as it can be undesirable to have condensation in the breath sample collection apparatus 20.
- the breath input interface can be constructed to receive breath from other animals.
- the conduits of the breath sample collection apparatus 20 are made of stainless steel that is coated with an inert coating.
- the inert coating can be made of any suitably inert substance, such as a silica-based or quartz material.
- An exhaust conduit 48 is connected to and branches from the breath intake conduit 44 at a first end thereof.
- a set of metering devices are positioned along the exhaust conduit 48, including a hygrometer 52 to measure the humidity in the exhaust conduit 48. Condensation can deteriorate the function of the breath sample collection apparatus 20 in that components of a person’s breath can be trapped by this condensation, thus not being correctly represented in the collected breath sample. Further, certain levels of humidity and/or condensation can impact the function of other components of the breath sample collection apparatus 20.
- a capnometer 56 is positioned along the exhaust conduit 48 to measure the carbon dioxide content of a patient’s breath. Also positioned along the exhaust conduit 48 is a flow meter 60 that determines the flow rate of the breath along the exhaust conduit 48.
- a low-pressure resistance portion 64 along the exhaust conduit 48 provides a low amount of resistance to the flow of gas along the exhaust conduit 48 towards an exhaust conduit outlet 68 at a second end of the exhaust conduit 48.
- the low-pressure resistance portion 64 acts as a cap on the exhaust conduit 48 and inhibits return diffusion gas from entering the exhaust conduit 48 while allowing gas to flow in both directions if needed.
- Any suitable structure can be employed to provide the low-pressure resistance portion 64, such as a flexible or hinged flap, a section of conduit having a restricted cross-section or change(s) in direction, etc.
- An air circulation system includes a pump conduit 76 that branches from the exhaust conduit 48 and terminates at a pump 72 that is driven by a motor.
- the pump 72 is configured to draw ambient air in and through the exhaust conduit 48 and the breath intake conduit 44, such as via the mouthpiece 36, and expel it into the surrounding environment, when needed. Any fluid pump that is suitable for use with gases can be employed.
- the inner diameter size of the mouthpiece 36 and the conduit portions 44, 48 are selected to provide only insignificant resistance to the exhalation of breath through the mouthpiece 36. Further, the conduit portions 44, 48 can be heated or cooled as desired to control the formation of condensation therealong. This can be desirable so that condensation is less likely to pass through to the breath sample collection devices, such as sorbent tubes.
- a breath collection valve 80 is connected to the breath intake conduit 44 and controls the flow of a gas from the breath input interface 24 of the breath intake conduit 44 to a breath collection conduit 84 of the breath capture conduit system 82.
- the breath intake conduit 44 forms part of the direct path between the breath input interface 24 and the breath capture conduit system 82.
- An intake valve 88 controls the flow of gas entering or exiting the breath collection conduit 84 via an ambient air inlet 92.
- An air filter 96 is positioned between the ambient air inlet 92 and the intake valve 88 and filters incoming ambient air to inhibit the entry to particulate contamination therein.
- a container is in fluid communication with the breath collection conduit 84 and is configured to store breath received from the breath collection conduit.
- the container in this embodiment includes a piston chamber 100 having a cavity 104 therein defined at least partially by interior walls of the piston chamber 100.
- the piston chamber 100 has a two-liter capacity and can have any suitable cross-sectional shape.
- a piston 108 corresponds in shape to and is positioned within the piston chamber 100 and is driven by a piston motor 112. The piston 108 seals against the sides of the piston chamber 100 to provide an airtight seal.
- the piston motor 112 can be any suitable type of motor to actuate the piston 108 within the piston chamber 100.
- the volume of the cavity 104 is directly mechanically controllable by the positioning of the piston 108 within the piston chamber 100 by the piston motor 112. Further, the volume change rate of the cavity 104 is controllable by actuating the piston 108 within the piston chamber 100 at a corresponding rate to either increase the volume of the cavity 104, defining a volume increase rate, by moving further into the piston chamber 100, or decrease the volume of the cavity 104, defining a volume decrease rate, by moving further out of the piston chamber 100.
- the piston chamber is constructed with an interior space, and the piston has a similar profile to slidingly move through the interior space of the piston chamber.
- the breath collection conduit 84 is connected to a tube manifold 116.
- the tube inlet manifold 116 branches to four tube inlet valves 120.
- a bypass conduit 124 branches from the breath collection conduit 84 and has a bypass valve 128 positioned along the bypass conduit 124 to prevent or allow the flow of gas therealong.
- An outlet valve 132 is positioned towards an outlet 136 and controls the flow of gas through the outlet 136.
- a tube outlet manifold 140 is connected to the bypass conduit 124 and branches to four tube outlet valves 144.
- the tube inlet valves 120 and the tube outlet valves 144 have connectors for receiving sorbent tubes.
- the breath sample collection apparatus 20 can be configured to receive and use any number of sorbent tubes.
- a controller 148 controls operation of the breath sample collection apparatus 20.
- the controller 148 is connected to the valves 80, 88, 120, 128, 132, and 144 to open and close these valves as described herein below.
- the functionality of the controller 148 can be performed by two or more controllers.
- a display 150 is controlled by the controller 148 to present instructions and information to a person, as well as metrics collected by the breath sample collection apparatus 20, such as the completeness of the procedure, the estimated amount of time remaining, etc.
- the internal components with which the breath comes into contact are generally inert.
- the conduits and valves are made of stainless steel and have an inert coating.
- Sealing elements within the valves are made of FKM, a family of fluoroelastomer materials, or another suitable resilient material that has a very low rate of off-gassing. While the polypropylene mouthpiece 36 can off-gas, the level is within an acceptable tolerance level.
- the sorbent tube 152 has a stainless-steel casing 156 that is tubular, defining an aperture 160 at each end thereof.
- a receiving end 164 of the sorbent tube 152 receives a gaseous fluid to be adsorbed.
- the gaseous fluid is human breath collected from a human fortesting.
- a foam separator 168 is positioned towards the receiving end and is configured to distribute fluid pressure more evenly across the cross-section of the stainless-steel casing 156.
- An adsorbent material 172 is positioned adjacent to the foam separator 168 and another foam separator 110.
- the separators may alternatively be made of a wire mesh or other suitable material.
- the adsorbent material 172 is very porous, has a relatively high surface area, and is selected for sampling specific compounds to trap and retain the compounds of interest even in the presence of other compounds. Further, the adsorbent material 172 allows the collected compounds to be easily desorbed or extracted for analysis.
- the solid adsorbent which is selected does not react with the sample. In the particular example, the solid adsorbent is Tenax TA or a carbon material. As a gaseous fluid is received via the receiving end 164, the sample is more concentrated towards the receiving end 164 of the sorbent tube 152.
- the composition and configuration of the sorbent tubes can vary, as will be appreciated by a person skilled in the art.
- a method 200 of collecting a breath sample using the breath sample collection apparatus 20 will now be discussed with reference to Figs. 1, 3, and 4A to 4G.
- the method 200 commences with the drawing in of ambient air into the system (210).
- the system is flushed of any stale residual air by drawing ambient air in and then expelling it through the conduits 44, 48, 68, 76, 84, and 124. This is done to ensure that there is no cross-contamination from breath from a previous person with breath being presently collected. Stale room air in the system is replaced with fresh room air during this flush.
- the controller 148 directs the intake valve 88 to open, and the piston motor 112 to operate to withdraw the piston 108 in the piston chamber 100.
- the cavity 104 defined by the interior walls of the piston chamber 100 and the piston 108 which is airtight sealed thereagainst increases in volume.
- the pressure within the cavity 104 rapidly decreases. Ambient air is drawn in through the ambient air inlet and the air filter 96, and into the cavity 104.
- FIG. 4A shows the cavity 104 filled with ambient air that has been drawn in.
- valves that are open will include stippling and valves that are closed will be free of stippling.
- the air filter 96 removes particulate from the ambient air as it is drawn in and before it enters the breath collection conduit 84. While the breath collection valve 80 is closed during this intake of ambient air, traces of breath from a previous person may be present along the breath intake conduit 44 and along the exhaust conduit 48. It is desirable to maintain the breath collection valve 80 closed so that only ambient air with drawn in and so that it is filtered via the air filter 96.
- the ambient air is used to flush the system (208).
- the controller upon withdrawing the piston 108 in the piston chamber 100, closes the intake valve 88 and then opens all the other valves. Once the valves 80, 120, 128, 132, and 144 have been opened, the controller 148 directs the piston motor 112 to drive the piston 108 into the piston chamber 100 to force the ambient air therein through the breath intake conduit 44 and out the mouthpiece 36, through the exhaust conduit 48 and out the exhaust conduit outlet 68, through the breath collection conduit 84 and the tube inlet manifold 116 and out the tube inlet valves 120, and through the bypass conduit 124 and the tube outlet manifold 140 and out the outlet 136 and the tube outlet valves 144. As a result, the conduits of the system are effectively filled with ambient air.
- FIG. 4B shows the flushing of the breath sample collection apparatus 20.
- the controller 148 determines if the flush is to be repeated (212). The flush is repeated five to ten times, with about ten to 20 liters of air to reduce the probability of breath from a previous person contaminating the breath sample to be taken. If it is determined that the required number of flushes has not yet been completed, the controller 148 commences the process of drawing in ambient air again at 204.
- one or more sorbent tubes 152a to 152d are loaded into the breath sample collection apparatus 20 (213).
- the bypass valve 128 and the outlet valve 132 are closed.
- One to four sorbent tubes 152 are then loaded into the breath sample collection apparatus 20.
- samples of ambient air are used as controls to which the breath sample can be compared.
- the ambient air that is breathed in by a person during the providing of a breath sample may contain some compounds that will register during analysis of the breath sample.
- ambient air can be adsorbed in one or more sorbent tubes 152.
- the breath sample collection apparatus 20 performs ambient air collection in a somewhat similar manner to breath collection.
- at least two sorbent tubes 152 are loaded so that at least one can capture ambient and at least another can capture breath.
- the ambient air is flowed through a subset of the sorbent tubes 152, as shown in FIG. 4D (215).
- the controller 148 opens a first of the tube inlet valves 120 and a first of the tube outlet valves 144, as well as the outlet valve 132.
- the controller 148 directs the piston motor 112 to actuate the piston 108 to move into the piston chamber 100 to decrease the volume of the cavity 104.
- the ambient air in the cavity 104 is impelled through a first sorbent tube 152a and out through the outlet 136.
- the rate at which the ambient air is flowed through the sorbent tube 152a is selected to provide effective adsorption while being time-efficient.
- a person 180 from which a breath sample is being collected is directed via the display 150 to exhale into the mouthpiece 36 during a process referred to as “breath pre-collection”, as is shown in FIG. 4E (216).
- “Breath pre-collection” is used to accustom the person 180 with the sensation of exhaling into the breath sample collection apparatus 20 in a specified manner according to criteria set out for operation of the breath sample collection apparatus 20.
- the display 150 presents instructions to the person 180 regarding a target exhalation rate of 20 liters per minute.
- the person 180 typically becomes more consistent in their breaths. People typically are much better able to control their exhalation rate after performing even just one breath exhalation of training.
- the breath provided during the breath pre-collection phase is used to prime the conduits of the system.
- the capnometer 56 is sampling the air to determine the level of carbon dioxide therein. As the capnometer 56 is sampling the air frequently, the capnometer 56 can also determine the rate of change of the level of carbon dioxide.
- the flow meter 60 determines the flow rate of the breath.
- the low-pressure resistance portion 64 provides very low flow restriction to exhalation by the person 180, and the breath exits through the exhaust conduit outlet 68.
- the controller 148 constantly monitors signals from the capnometer 56 and the flow meter 60 to determine if a set of breath collection criteria are met.
- breath collection criteria are (a) the carbon dioxide level reported by the capnometer 56 is within a target range defined by a minimum threshold and an infinite upper bound; (b) the rate of change of the carbon dioxide level is within a change rate target range defined by an infinite lower bound and a change rate maximum threshold; and (c) the flow rate of the breath exhalation is within a target range defined by a minimum flow rate threshold and a maximum flow rate threshold.
- the minimum flow rate threshold is 20 liters per minute and the maximum is 25 liters per minute. Having the flow rate of breath be within a target range provides consistency to the breath provided by the person 180.
- the target ranges can be defined by a threshold at one of its bounds as the other bound can be logically satisfied, such as an infinite or zero bound.
- the first part of the breath of the person 180 includes air from the mouth or and/or throat for which oxygen/carbon dioxide exchange did not occur in the lungs, thereby giving it a higher percentage of oxygen.
- a greater portion of the breath is from the lungs where oxygen/carbon dioxide exchange occurs.
- the carbon dioxide released from the blood stream becomes a larger contingent (about 3-7%) of the breath.
- the carbon dioxide level hits a knee when the change rate thereof decreases dramatically. This indicates that the breath is from inside the lungs, instead of the breath from the mouth or the windpipe/trachea.
- This breath is referred to as alveolar breath.
- the target range for the carbon dioxide level is from 3% of the breath to an infinite upper bound
- the change rate target range for the carbon dioxide level is from 0% to 2% of the breath per second.
- FIG. 5 shows the carbon dioxide level in exhaled breath over time relative to a threshold W.
- the rate of change of the carbon dioxide level is generally consistently elevated until alveolar breath is being exhaled, at which point the rate of change in the carbon dioxide level drops significantly, This change of rate is reflected as a knee K. Thereafter, the carbon dioxide level in the exhaled alveolar breath is stable.
- the breath collection criteria are as follows.
- the carbon dioxide level is above a threshold of 2%. This level is well above atmospheric levels, but below what is expected to be seen in a person (e.g., 3% is lowest from people with poor lung function).
- the rate of change of the carbon dioxide level is below a specified threshold. Further, the flow rate of the breath exhalation exceeds 20 liters per minute.
- breath collection commences as is illustrated in FIG. 4F (224).
- the controller 148 opens the breath collection valve 80 and directs the piston motor 112 to drive the piston 108 to increase the volume of the cavity 104 as the breath is being received.
- the piston 108 is controlled to actuate at a rate dependent upon the flow rate reported by the flow meter 60 to provide a volume increase rate for the cavity 104.
- the volume increase rate of the cavity 104 achieved as a result of actuating the piston 108 is proportional to the flow rate detected by the flow meter 60 along the exhaust conduit 48.
- the volume change rate of the cavity 104 can be changed in a different manner as a function of the flow rate reported by the flow meter 60.
- the flow meter 60 is positioned along a normally downstream path for airflow to inhibit the contamination of a presently collected breath sample with breath from a previous breath sample provider that adhered to the flow meter 60. If the actuation rate of the piston 108, and thus the increase rate of the cavity volume, were fixed, more or less of the breath would be expelled via the flow meter 60 when the person 180 exhaled more rapidly. This can result in a more-than-desired amount of the exhaled breath escaping along the exhaust conduit 48, and issues when the flow rate drops below the volume increase rate of the cavity 104.
- the controller 148 controls the piston 108 to increase the volume of the cavity 104 at a rate that is dependent on the flow rate measured by the flow meter 60.
- the volume of the cavity 104 is increased at four times the flow rate measured by the flow meter 60. That is, the increase in volume of the cavity 104 captures 80% of the breath received from the person 180.
- the hygrometer 52, the capnometer 56, and the flow meter 60 are all positioned along the exhaust conduit 48, away from the breath intake conduit 44. These metering devices can off-gas VOCs. Further, these metering devices can become contaminated by the breath of a person from which breath was previously collected. By placing these metering devices along the exhaust conduit 48, along which breath flows away from the direct path along the breath intake conduit 44, contamination by the other breath or off gassed VOCs is inhibited.
- these metering devices and the conduits are provided with an inert internal coating to reduce the probability that breath or off-gassed VOCs adhere to their internal surfaces to thereby further reduce the probability of contamination of a breath sample by the previously received breath and off-gassed VOCs.
- the overall generally unrestricted breath exhalation rate can be determined.
- This breath exhalation rate is equal to the flow rate measured by the flow meter 60 plus the rate of increase of the volume of the cavity 104 determined based on the actuation rate of the position of the piston 108.
- This breath exhalation rate can then be used to determine how fast to increase the volume of the cavity 104.
- some of the breath will always travel down the exhaust conduit 48 to enable continued monitoring of the overall breath exhalation rate.
- This ratio of 80% of the overall breath exhalation rate has been selected to afford a reaction time buffer so that if the exhalation rate of the person quickly drops off, the volume increase rate of the cavity 104 can be adjusted with a minor amount of lag with very little chance of exceeding the breath exhalation rate. If the volume increase rate of the cavity 104 exceeds the breath exhalation rate of the person, the pressure differential in the system may draw breath from the person unnaturally, which can be an undesirable outcome, and can draw in ambient air through the exhaust conduit outlet 68.
- Information regarding the overall exhalation rate is presented to the person 180 on the display 150 to encourage the person 180 to exhale within the target range or at least at the threshold rate.
- the piston 108 is actuated by the controller to move to cause the cavity 104 to increase in volume so that 80% of the exhaled breath is collected within the cavity 104.
- the piston speed is adjusted so that the change in volume of the cavity 104 is always below the rate of exhalation to ensure that no air is pulled in via the flow meter route and that the flow rate of breath can be metered via the flow meter 60.
- the flow rate termination range in the present embodiment is from an infinite lower bound to two liters of breath per minute.
- the person 180 may not have enough breath to fill the entire piston chamber 100. Accordingly, once the flow meter 60 reports that the exhalation rate drops below a certain value, movement of the piston 108, and thus breath collection, is stopped.
- the controller 148 determines if a target volume has been collected to prime the system (228).
- the breath sample collection apparatus 20 collects one liter of breath to prime the system. If less than the target volume of one liter of breath has been collected, the controller 147 controls the breath sample collection apparatus 20 to perform breath pre collection at 216.
- the collected breath is used to prime the system, as is shown in FIG. 4G (232).
- the controller 184 directs the breath collection valve 80 to close, and the bypass valve 128 and the outlet valve 132 to open. Further, the piston motor 112 is directed to drive the piston 108 into the piston chamber 100, thereby reducing the volume of the cavity 104.
- the breath contained therein is impelled through the breath collection conduit 84, the tube inlet manifold 116, the tube outlet manifold 140, the bypass conduit 124, and out the outlet 136. This primes these conduits with the collected breath of the person 180.
- breath is collected again using the same general approach at 216 to 228. That is, breath pre-collection is performed again (240). During breath pre-collection, the controller 148 determines if the breath exhalation criteria are satisfied (244). If they are, breath is collected as is shown in FIG. 4H (248).
- FIG. 4I illustrates the piston chamber 100 having been filled with breath.
- the controller 148 is configured to control a flow of the at least some of the breath from the container to a subset of the sorbent tubes 152 asynchronous of when the exhaled breath is received. That is, the flowing of breath from the container to a subset of the sorbent tubes 152 can be performed independent of when the exhaled breath is received, apart from having to occur after receiving the exhaled breath.
- the second subset can be any number of the sorbent tubes 152 connected to the breath sample collection apparatus 20 that have not been adsorbed with ambient air.
- the controller 148 closes the breath collection valve 80, and controls each of the tube inlet valves 120, either leaving the tube inlet valves 120 in their previously closed or open state or opening or closing each of the tube inlet valves 120, to select a subset of the sorbent tubes 152 through which the at least some of the breath is flowed through.
- the controller 148 opens a corresponding one of the tube inlet valves 120 and the tube outlet valves 144 for a sorbent tube 152 in which the sample is to be adsorbed, as well as the outlet valve 132.
- the piston 108 is controlled by the controller 148 to slowly move to push the breath therein through the selected sorbent tube 152 at a predetermined rate pushing breath through the designated sorbent tube 152.
- the controller 148 controls the pump 72 to turn on to draw ambient air from the mouthpiece 36 and the exhaust conduit outlet 68 and through the exhaust conduit 48 to help relieve condensation out of the line.
- the pump 72 acts to lower condensation/humidity in the exhaust conduit 48.
- the humidity level is monitored via the hygrometer 52.
- FIG. 6 shows a typical graph of humidity level detected by the hygrometer 52 over time.
- the humidity Before the pump 72 is turned on at ti, the humidity is at a first level hi. High levels of condensation can be observed in the clear mouthpiece 36.
- the change rate in the humidity level is negative as the humidity level drops overtime.
- the controller 148 terminates operation of the pump 72, as it is deemed that the pre-collection conduit system 46 is relatively free of condensation and that continued operation of the pump 72 has relatively little value.
- This humidity level change rate target range in the present embodiment is -0.05% relative humidity per second to 0% relative humidity per second, but can be varied in other scenarios.
- this condensation reduction phase can be run based on a humidity level being outside of a humidity level target range of values from zero to the humidity level of the ambient air via use of a secondary external hygrometer.
- the rate at which the breath is flowed through the sorbent tube 152 is 500 milliliters per minute. It has been found that the break-through volume for the sorbent tube 152 is affected by the adsorb flow rate. The break-through volume is the volume at which half of the sample is captured by a sorbent tube 152 and the other half flows through to the other side of the sorbent tube 152.
- the adsorbent in the sorbent tube 152 is at the point where enough surface is used so that it is just as easy for molecules to go through as it is for molecules to be trapped. Increasing the flow rate of breath through a sorbent tube 152 decreases the break-through volume. This skews the captured sample to the heavier molecules and less of the smaller molecules. By controlling the flow rate of the breath through the sorbent tubes 152, the adsorption rate for certain molecules can be controlled.
- the controller 148 can terminate flowing the breath through the sorbent tube 152 via the tube inlet and outlet valves 120, 144 and commence flowing the breath through another of the sorbent tubes 152.
- the breath sample collection apparatus 20 can be configured to select different sized subsets of the sorbent tubes for ambient air and breath samples. In one preferred embodiment, two sorbent tubes of ambient air samples and two sorbent tubes of breath samples are collected. In other embodiments, no ambient air may be collected.
- the controller 148 is connected to each of the valves, the hygrometer 52, the capnometer 56, the flow meter 60, the pump 72, the piston motor 112, as well as other components of the breath sample collection apparatus 20.
- the container with a controllable volume can be any other structure for providing a cavity with a controllable volume.
- the container can include a bellows-like structure.
- FIG. 7A shows a breath sample collection apparatus 300 in accordance with another embodiment.
- the breath sample collection apparatus 300 is similar to the breath sample collection apparatus 20 of FIGS. 1 and 4A to 4I, except that the breath sample collection apparatus 300 employs a two-way pump 304 and a container that includes an at least partially flexible collapsible receptacle 308 in place of the piston chamber 100 and piston 108.
- the at least partially flexible collapsible receptacle 308 is secured to the two- way pump 304 that is, in turn, secured to the breath collection conduit 84.
- the at least partially flexible collapsible receptacle 308 is a bag made of polyvinyl fluoride, a highly flexible material that has high tensile characteristics. While not impermeable, It has a suitably low permeability that, for this application, does not impact its performance significantly. Further, it is relatively inert. Other suitably flexible, relatively non-porous, and relatively inert materials can additionally or alternatively be used in other embodiments. Further, the receptacle can also include inflexible portions.
- the at least partially flexible collapsible receptacle 308 has an interior cavity that has a volume defined by the amount of a fluid therein.
- FIG. 7A the at least partially flexible collapsible receptacle 308 is shown having substantially no breath or ambient air therein, and thus the cavity has substantially no volume. In this collapsed state, the at least partially flexible collapsible receptacle 308 can be compacted to facilitate packing.
- the two-way pump 304 has a controllable flow rate and flows breath and/or ambient air in both directions. It is controllable by the controller 148 to draw breath and/or ambient air from the breath collection conduit system 82 into the at least partially flexible collapsible receptacle 308, and draws breath and/or ambient air from the at least partially flexible collapsible receptacle 308 into the breath collection conduit system 82.
- the controller 148 can control the two-way pump 304 and, as a result, the at least partially flexible collapsible receptacle 308 to provide the same general functionality as the piston chamber 100, the piston motor 112, and the piston 108. That is, the controller 148 can, through operation of the pump, control the volume of the at least partially flexible collapsible receptacle 308.
- FIG. 7B shows the at least partially flexible collapsible receptacle 308 after the two-way pump 304 has drawn breath and/or ambient air therein, thus enlarging the cavity of the at least partially flexible collapsible receptacle 308 and the at least partially flexible collapsible receptacle 308 itself.
- the breath sample collection apparatus 300 also differs in that it has an array of light elements in the form of LEDs 312 and an audio speaker 316 in place of a display. Flow rate notifications can be presented to a user via the LEDs 312.
- the array of LEDs 312 can include a sequence of a red LED, a yellow LED, a green LED, a yellow LED, and a red LED.
- a corresponding red or yellow LED can be illuminated.
- the green LED can be illuminated.
- a corresponding second red or yellow LED can be illuminated. In this manner, a person can be shown visually how his breath flow rate compares to a target flow rate.
- other types of light elements can be employed.
- the audio speaker 316 can be used in a similar manner, with flow rate notifications being provided by means of clicks of different frequencies, sounds of different frequencies, different sounds, etc.
- FIG. 8 shows a breath sample collection apparatus 400 in accordance with a further embodiment.
- the flow meter 60 is positioned along the breath intake conduit 44.
- the flow meter 60 measures the full exhaled breath rate along the breath intake conduit 44.
- the controller 148 can control the piston motor 112 to actuate the piston 108 so that the volume change rate of the cavity 104 is set to a proportion of the flow rate measured by the flow meter 60.
- the volume change rate of the cavity 104 is set to 80% of the flow rate measured by the flow meter 60 during breath collection. The excess breath flows along the exhaust conduit 48 and out the exhaust conduit outlet 68.
- a capnometer is employed to measure the level of carbon dioxide in the breath
- other types of metering devices can be employed for measuring the levels of other constituents in the breath, such as those that can indicate when alveolar breath is being detected. These metering devices can detect levels and change rates in these levels of these other constituents to determine when alveolar breath is being detected.
- a metering device can measure an oxygen level in the breath and, upon detecting that the change in the oxygen level has fallen within a change rate target range having a change rate maximum threshold, it can be determined that alveolar breath is now being detected.
- breath sample storage devices apart from sorbent tubes can be employed.
- solid-phase microextraction (“SPME”) fibres can be alternatively used to store the breath sample.
- SPME solid-phase microextraction
- silica gel is another example.
- Other types of breath sample storage devices will occur to those skilled in the art.
- the volume of the container can be mechanically controlled in other manners.
- the container can include a bellows that can be actuated to expand and contract.
- breath sample collection apparatus 24 breath input interface
- 82 capture conduit system breath collection conduit intake valve ambient air inlet air filter piston chamber cavity piston piston motor tube inlet manifold tube inlet valve bypass conduit bypass valve outlet valve outlet tube outlet manifold tube outlet valve controller display sorbent tube stainless-steel casing aperture receiving end foam separator adsorbent material foam separator person method draw ambient air flush system repeat flush? load sorbent tubes draw ambient air flow air through first subset of sorbent tubes breath pre-collection breath exhalation criteria satisfied? breath collected to prime system target volume? prime system with collected breath load sorbent tubes breath pre-collection breath exhalation criteria satisfied collect breath target volume or full container? flow breath through sorbent tube(s) flow air through pre-capture conduit system to reduce condensation target volume? breath sample collection apparatus two-way pump flexible collapsible receptacle LEDs speaker
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Surgery (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Physiology (AREA)
- Physics & Mathematics (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2022552157A JP2023516023A (ja) | 2020-02-28 | 2021-01-28 | 制御可能な容積の容器を使用した呼気試料の採取装置および方法 |
EP21759949.7A EP4110179A4 (en) | 2020-02-28 | 2021-01-28 | APPARATUS AND METHOD FOR COLLECTING AN EXHARED AIR SAMPLE USING A CONTROLLABLE VOLUME CONTAINER |
CA3169784A CA3169784A1 (en) | 2020-02-28 | 2021-01-28 | Apparatus and method for collecting a breath sample using a container with controllable volume |
AU2021227721A AU2021227721A1 (en) | 2020-02-28 | 2021-01-28 | Apparatus and method for collecting a breath sample using a container with controllable volume |
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16/805,187 | 2020-02-28 | ||
US16/805,176 US11957450B2 (en) | 2020-02-28 | 2020-02-28 | Apparatus and method for collecting a breath sample using an air circulation system |
US16/805,161 | 2020-02-28 | ||
US16/805,156 US20210267481A1 (en) | 2020-02-28 | 2020-02-28 | Apparatus and method for controlling a flow of breath to a sorbent tube |
US16/805,176 | 2020-02-28 | ||
US16/805,156 | 2020-02-28 | ||
US16/805,142 | 2020-02-28 | ||
US16/805,187 US20210267485A1 (en) | 2020-02-28 | 2020-02-28 | Apparatus and method for collecting a breath sample using a metering device along an exhaust conduit |
US16/805,142 US11782049B2 (en) | 2020-02-28 | 2020-02-28 | Apparatus and method for collecting a breath sample using a container with controllable volume |
US16/805,161 US20210267482A1 (en) | 2020-02-28 | 2020-02-28 | Apparatus and method for collecting a breath sample using a metering device |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2021168544A1 true WO2021168544A1 (en) | 2021-09-02 |
Family
ID=77489696
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CA2021/050090 WO2021168543A1 (en) | 2020-02-28 | 2021-01-28 | An apparatus and method for collecting a breath sample using a metering device along an exhaust conduit |
PCT/CA2021/050088 WO2021168541A1 (en) | 2020-02-28 | 2021-01-28 | Apparatus and method for collecting a breath sample using a metering device |
PCT/CA2021/050087 WO2021168540A1 (en) | 2020-02-28 | 2021-01-28 | Apparatus and method for controlling a flow of breath to a sorbent tube |
PCT/CA2021/050091 WO2021168544A1 (en) | 2020-02-28 | 2021-01-28 | Apparatus and method for collecting a breath sample using a container with controllable volume |
PCT/CA2021/050092 WO2021168545A1 (en) | 2020-02-28 | 2021-01-28 | Apparatus and method for collecting a breath sample |
PCT/CA2021/050089 WO2021168542A1 (en) | 2020-02-28 | 2021-01-28 | Apparatus and method for collecting a breath sample using an air circulation system |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CA2021/050090 WO2021168543A1 (en) | 2020-02-28 | 2021-01-28 | An apparatus and method for collecting a breath sample using a metering device along an exhaust conduit |
PCT/CA2021/050088 WO2021168541A1 (en) | 2020-02-28 | 2021-01-28 | Apparatus and method for collecting a breath sample using a metering device |
PCT/CA2021/050087 WO2021168540A1 (en) | 2020-02-28 | 2021-01-28 | Apparatus and method for controlling a flow of breath to a sorbent tube |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CA2021/050092 WO2021168545A1 (en) | 2020-02-28 | 2021-01-28 | Apparatus and method for collecting a breath sample |
PCT/CA2021/050089 WO2021168542A1 (en) | 2020-02-28 | 2021-01-28 | Apparatus and method for collecting a breath sample using an air circulation system |
Country Status (5)
Country | Link |
---|---|
EP (6) | EP4110180A4 (ja) |
JP (6) | JP2023516019A (ja) |
AU (6) | AU2021226139A1 (ja) |
CA (6) | CA3169775A1 (ja) |
WO (6) | WO2021168543A1 (ja) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050177056A1 (en) * | 2002-03-03 | 2005-08-11 | Oridion Breathid Ltd | Breath collection system |
US20140276100A1 (en) * | 2012-02-01 | 2014-09-18 | Invoy Technologies | System for measuring breath analytes |
US20180214050A1 (en) * | 2014-05-22 | 2018-08-02 | Picomole Inc. | Alveolar breath collection apparatus |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5386833A (en) * | 1993-12-23 | 1995-02-07 | Biochem International, Inc. | Method for calibrating a carbon dioxide monitor |
FI102511B (fi) * | 1995-06-26 | 1998-12-31 | Instrumentarium Oy | Pitoisuusmittaus hengitysilmasta |
CN102188247B (zh) * | 2002-09-16 | 2013-03-06 | 艾罗克林有限公司 | 用于诊断气体分析的设备和方法 |
US7547285B2 (en) * | 2003-02-14 | 2009-06-16 | The Charlotte-Mecklenburg Hospital Authority | Device and method for collection of exhaled alveolar breath condensate |
US20060200037A1 (en) * | 2005-03-02 | 2006-09-07 | Falasco Marianne R | System and method for selectively collecting exhaled air |
US9044565B2 (en) * | 2008-10-30 | 2015-06-02 | Oridion Medical (1987) Ltd. | Oral-nasal cannula system enabling CO2 and breath flow measurement |
US9643186B1 (en) * | 2010-03-19 | 2017-05-09 | Invoy Technologies, Llc | Breath analysis system, device and method employing nanoparticle-based sensor |
GB201018711D0 (en) * | 2010-11-05 | 2010-12-22 | Univ Manchester | Apparatus and methods for breath sampling |
DE102010054397A1 (de) * | 2010-12-08 | 2012-06-14 | Aerocrine Ab | Verfahren und Vorrichtung zur Gasprobensammlung |
AU2014216297A1 (en) * | 2013-02-12 | 2015-09-17 | Capnia, Inc. | Sampling and storage registry device for breath gas analysis |
EP2769673B1 (en) * | 2013-02-21 | 2015-04-22 | Cosmed S.r.l. | Device for measuring the consumption of oxygen and the elimination of carbon dioxide by a subject |
DE102013215640A1 (de) * | 2013-08-08 | 2015-02-12 | Siemens Aktiengesellschaft | Anordnung zur Entnahme von Atemgasproben |
US10307080B2 (en) * | 2014-03-07 | 2019-06-04 | Spirosure, Inc. | Respiratory monitor |
CN106062558B (zh) * | 2014-03-26 | 2019-01-25 | 普和希控股公司 | 呼出气体测量装置及呼出气体测量装置的控制方法 |
CA2892870C (en) * | 2014-05-22 | 2020-10-27 | Picomole Instruments Inc. | Alveolar breath collection apparatus |
DE102014219161A1 (de) * | 2014-09-23 | 2016-03-24 | Robert Bosch Gmbh | Vorrichtung zur Analyse der Ausatemluft und Verwendung der Vorrichtung |
WO2016061533A1 (en) * | 2014-10-17 | 2016-04-21 | Digital Ally, Inc. | Breath analyzer, system, and computer program for authenticating, preserving, and presenting breath analysis data |
US20180153439A1 (en) * | 2015-06-08 | 2018-06-07 | The Board Of Trustees Of The Leland Stanford Junior University | Time-Resolved Single-breath Analysis Using Spectroscopic Methods |
US10226201B2 (en) * | 2015-10-29 | 2019-03-12 | Invoy Holdings, Llc | Flow regulation device for breath analysis and related method |
ES2967759T3 (es) * | 2016-04-25 | 2024-05-03 | Owlstone Med Ltd | Sistemas y dispositivos de captación de muestras de aliento |
WO2018150738A1 (ja) * | 2017-02-15 | 2018-08-23 | Phcホールディングス株式会社 | 呼気測定装置 |
WO2018157172A1 (en) * | 2017-02-27 | 2018-08-30 | Third Pole, Inc. | Systems and methods for generating nitric oxide |
WO2019074922A1 (en) * | 2017-10-10 | 2019-04-18 | Endo Medical, Inc. | BREATH ANALYSIS DEVICE |
CA2997070A1 (en) * | 2018-03-02 | 2019-09-02 | Picomole Inc. | Alveolar breath collection apparatus |
-
2021
- 2021-01-28 EP EP21760418.0A patent/EP4110180A4/en active Pending
- 2021-01-28 CA CA3169775A patent/CA3169775A1/en active Pending
- 2021-01-28 CA CA3169789A patent/CA3169789A1/en active Pending
- 2021-01-28 EP EP21759861.4A patent/EP4110178A4/en active Pending
- 2021-01-28 WO PCT/CA2021/050090 patent/WO2021168543A1/en active Application Filing
- 2021-01-28 JP JP2022552153A patent/JP2023516019A/ja active Pending
- 2021-01-28 AU AU2021226139A patent/AU2021226139A1/en active Pending
- 2021-01-28 EP EP21759949.7A patent/EP4110179A4/en active Pending
- 2021-01-28 WO PCT/CA2021/050088 patent/WO2021168541A1/en active Application Filing
- 2021-01-28 AU AU2021228377A patent/AU2021228377A1/en active Pending
- 2021-01-28 JP JP2022552154A patent/JP2023516020A/ja active Pending
- 2021-01-28 CA CA3169777A patent/CA3169777A1/en active Pending
- 2021-01-28 AU AU2021227720A patent/AU2021227720A1/en active Pending
- 2021-01-28 CA CA3169784A patent/CA3169784A1/en active Pending
- 2021-01-28 JP JP2022552157A patent/JP2023516023A/ja active Pending
- 2021-01-28 WO PCT/CA2021/050087 patent/WO2021168540A1/en active Application Filing
- 2021-01-28 AU AU2021227721A patent/AU2021227721A1/en active Pending
- 2021-01-28 WO PCT/CA2021/050091 patent/WO2021168544A1/en active Application Filing
- 2021-01-28 CA CA3169788A patent/CA3169788A1/en active Pending
- 2021-01-28 EP EP21759776.4A patent/EP4110177A4/en active Pending
- 2021-01-28 AU AU2021226138A patent/AU2021226138A1/en active Pending
- 2021-01-28 WO PCT/CA2021/050092 patent/WO2021168545A1/en active Application Filing
- 2021-01-28 JP JP2022552158A patent/JP2023516024A/ja active Pending
- 2021-01-28 EP EP21761561.6A patent/EP4110181A4/en active Pending
- 2021-01-28 AU AU2021228378A patent/AU2021228378A1/en active Pending
- 2021-01-28 JP JP2022552159A patent/JP2023516025A/ja active Pending
- 2021-01-28 CA CA3169780A patent/CA3169780A1/en active Pending
- 2021-01-28 JP JP2022552156A patent/JP2023516022A/ja active Pending
- 2021-01-28 EP EP21761687.9A patent/EP4110182A4/en active Pending
- 2021-01-28 WO PCT/CA2021/050089 patent/WO2021168542A1/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050177056A1 (en) * | 2002-03-03 | 2005-08-11 | Oridion Breathid Ltd | Breath collection system |
US20140276100A1 (en) * | 2012-02-01 | 2014-09-18 | Invoy Technologies | System for measuring breath analytes |
US20180214050A1 (en) * | 2014-05-22 | 2018-08-02 | Picomole Inc. | Alveolar breath collection apparatus |
Non-Patent Citations (1)
Title |
---|
See also references of EP4110179A4 * |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US10925515B2 (en) | Alveolar breath collection apparatus | |
CN105388274B (zh) | 一种呼气一氧化氮和一氧化碳浓度的测量装置 | |
CA2997070A1 (en) | Alveolar breath collection apparatus | |
WO2008060165A1 (en) | Improvements in or relating to breath collection methods and apparatus | |
CN110226931A (zh) | 一种呼气分析装置及使用方法 | |
US11957450B2 (en) | Apparatus and method for collecting a breath sample using an air circulation system | |
US11782049B2 (en) | Apparatus and method for collecting a breath sample using a container with controllable volume | |
US20210267484A1 (en) | Apparatus and method for collecting a breath sample | |
US20210267482A1 (en) | Apparatus and method for collecting a breath sample using a metering device | |
US20210267485A1 (en) | Apparatus and method for collecting a breath sample using a metering device along an exhaust conduit | |
AU2021227721A1 (en) | Apparatus and method for collecting a breath sample using a container with controllable volume | |
US20210145313A1 (en) | Breath collection apparatus with downstream gas sampling device | |
JPH11271302A (ja) | 呼気採取方法及び装置 | |
US20240230624A9 (en) | Breath capture and analysis system and method | |
KR20240041529A (ko) | 호기 수집 장치 및 이를 이용한 호기 수집 방법 | |
WO2022169860A1 (en) | Breath capture and analysis system and method | |
CN117653212A (zh) | 呼出气体采集装置及采集方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 21759949 Country of ref document: EP Kind code of ref document: A1 |
|
ENP | Entry into the national phase |
Ref document number: 3169784 Country of ref document: CA |
|
ENP | Entry into the national phase |
Ref document number: 2022552157 Country of ref document: JP Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 202217054888 Country of ref document: IN |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
ENP | Entry into the national phase |
Ref document number: 2021759949 Country of ref document: EP Effective date: 20220928 |
|
ENP | Entry into the national phase |
Ref document number: 2021227721 Country of ref document: AU Date of ref document: 20210128 Kind code of ref document: A |