WO2021154491A1 - Stepper motor drive systems and tubing occluder system - Google Patents
Stepper motor drive systems and tubing occluder system Download PDFInfo
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- WO2021154491A1 WO2021154491A1 PCT/US2021/013094 US2021013094W WO2021154491A1 WO 2021154491 A1 WO2021154491 A1 WO 2021154491A1 US 2021013094 W US2021013094 W US 2021013094W WO 2021154491 A1 WO2021154491 A1 WO 2021154491A1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/367—Circuit parts not covered by the preceding subgroups of group A61M1/3621
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/80—Constructional details other than related to driving
- A61M60/855—Constructional details other than related to driving of implantable pumps or pumping devices
- A61M60/89—Valves
- A61M60/892—Active valves, i.e. actuated by an external force
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- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1698—Blood oxygenators with or without heat-exchangers
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/26—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving
- A61M1/267—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving used for pumping
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- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
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- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
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- A61M60/109—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems
- A61M60/113—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
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- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/20—Type thereof
- A61M60/205—Non-positive displacement blood pumps
- A61M60/216—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
- A61M60/226—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller the blood flow through the rotating member having mainly radial components
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- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/20—Type thereof
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- A61M60/253—Positive displacement blood pumps including a displacement member directly acting on the blood
- A61M60/268—Positive displacement blood pumps including a displacement member directly acting on the blood the displacement member being flexible, e.g. membranes, diaphragms or bladders
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- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/30—Medical purposes thereof other than the enhancement of the cardiac output
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- A—HUMAN NECESSITIES
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- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/80—Constructional details other than related to driving
- A61M60/845—Constructional details other than related to driving of extracorporeal blood pumps
- A61M60/851—Valves
- A61M60/853—Valves the valve being formed by a flexible tube element which is clamped for restricting the flow
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- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02P—CONTROL OR REGULATION OF ELECTRIC MOTORS, ELECTRIC GENERATORS OR DYNAMO-ELECTRIC CONVERTERS; CONTROLLING TRANSFORMERS, REACTORS OR CHOKE COILS
- H02P25/00—Arrangements or methods for the control of AC motors characterised by the kind of AC motor or by structural details
- H02P25/02—Arrangements or methods for the control of AC motors characterised by the kind of AC motor or by structural details characterised by the kind of motor
- H02P25/08—Reluctance motors
- H02P25/092—Converters specially adapted for controlling reluctance motors
- H02P25/0925—Converters specially adapted for controlling reluctance motors wherein the converter comprises only one switch per phase
-
- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02P—CONTROL OR REGULATION OF ELECTRIC MOTORS, ELECTRIC GENERATORS OR DYNAMO-ELECTRIC CONVERTERS; CONTROLLING TRANSFORMERS, REACTORS OR CHOKE COILS
- H02P29/00—Arrangements for regulating or controlling electric motors, appropriate for both AC and DC motors
- H02P29/02—Providing protection against overload without automatic interruption of supply
- H02P29/024—Detecting a fault condition, e.g. short circuit, locked rotor, open circuit or loss of load
- H02P29/0241—Detecting a fault condition, e.g. short circuit, locked rotor, open circuit or loss of load the fault being an overvoltage
-
- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02P—CONTROL OR REGULATION OF ELECTRIC MOTORS, ELECTRIC GENERATORS OR DYNAMO-ELECTRIC CONVERTERS; CONTROLLING TRANSFORMERS, REACTORS OR CHOKE COILS
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- H02P29/50—Reduction of harmonics
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- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02P—CONTROL OR REGULATION OF ELECTRIC MOTORS, ELECTRIC GENERATORS OR DYNAMO-ELECTRIC CONVERTERS; CONTROLLING TRANSFORMERS, REACTORS OR CHOKE COILS
- H02P8/00—Arrangements for controlling dynamo-electric motors rotating step by step
- H02P8/12—Control or stabilisation of current
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- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02P—CONTROL OR REGULATION OF ELECTRIC MOTORS, ELECTRIC GENERATORS OR DYNAMO-ELECTRIC CONVERTERS; CONTROLLING TRANSFORMERS, REACTORS OR CHOKE COILS
- H02P8/00—Arrangements for controlling dynamo-electric motors rotating step by step
- H02P8/14—Arrangements for controlling speed or speed and torque
- H02P8/16—Reducing energy dissipated or supplied
-
- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02P—CONTROL OR REGULATION OF ELECTRIC MOTORS, ELECTRIC GENERATORS OR DYNAMO-ELECTRIC CONVERTERS; CONTROLLING TRANSFORMERS, REACTORS OR CHOKE COILS
- H02P8/00—Arrangements for controlling dynamo-electric motors rotating step by step
- H02P8/32—Reducing overshoot or oscillation, e.g. damping
Definitions
- This document relates to stepper motor drive systems that can be used, for example, to drive a stepper motor of an occluder device in association with aheart- lung machine.
- Hollow' fiber oxygenators are utilized within the extracorporeal circuit to meet a patient’s gas exchange needs during medical procedures such as cardiopulmonary bypass surgery.
- Blood from the patient is either gravity drained, or VAVD (vacuum assisted venous drainage) is used to obtain the required amount of flow to maintain sufficient volume in a reservoir.
- a pump such as a peristaltic pump or a centrifugal pump coupled with a magnetic drive system, is sometimes used in the main line of the circuit in order to pump blood from the reservoir, through the oxygenator, and finally back to the patient.
- Flow' through such lines can be controlled by adjustably restricting the lines, such as by pinching the lines manually or through the use of a mechanism such as an occluder.
- Some occluders are driven by stepper motors.
- Stepper motors are generally brushless direct current (DC) motors that include a collection of electromagnetic coils. These coils can be energized and de-energized to cause the motor ' s rotor to rotate in evenly spaced subdivisions of rotation, or”steps”.
- the coils are energized and de-energized by a controller or an external driver circuit. To make the motor shaft turn, a coil is given power, which magnetically attracts the rotor.
- the next coil is turned on and the first is turned off, the rotor rotates slightly to align with the next coil. This process can then be repeated to control and rotate the rotor to a selected position or rotational distance with a selected speed.
- stepper motor drive systems that can be used, for example, to drive a stepper motor of an occluder device in association with a heart- lung machine.
- the stepper motor drive systems described herein can also be beneficially used in many other contexts in which stepper motors are used.
- this disclosure is directed to a tube occluder system that includes a tube clamp device configured to releasably receive a tube, a stepper motor having a first winding and a second winding, and arranged to adj ust an amount of compression applied to the tube by the tube clamp device, and a drive system electrically coupled to the stepper motor and including a first winding output port configured to electrically connect to a first winding input of the first winding, a first winding input port configured to electrically connect to a first winding output of the first winding, a second winding output port configured to electrically connect to a second winding input of a second winding, a second winding input port configured to electrically connect to a second winding output of the second winding, a first snubber circuit in electrical communication between the first winding input port and the second winding output port, and a second snubber circuit in electrical communication between the second winding input port and the first winding output port.
- the system can include some, all, or none of the following features.
- the first snubber circuit can include a resistor and a diode in series electrical connection with the resistor, and the diode is configured to pass current from the first winding input port to the second winding output port, and prevent current flow from the second winding output port to the first winding input port.
- the second snubber circuit can include a resistor and a second diode in series electrical connection with the second resistor, and the second diode is configured to pass current from the second winding input port to the first winding output port, and prevent current flow from the first winding output port, to the second winding input port.
- the tube occluder system can also include a power bus, a first diode configured to pass current from the pow3 ⁇ 4r bus to the first winding output port, and a second diode configured to pass current from the power bus to the second winding output port.
- the tube occluder system can also include a low electrical potential power bus, a first switch configured to eontrollably connect the first winding input port to the low electrical potential pow'er bus, and a second switch configured to eontrollably connect the second winding input port to the low electrical potential power bus, and at least one resistor configured to limit current flow from the first winding input port to the low electrical potential power bus and to limit current flow' from the second winding input port to the low electrical potential pow er bus.
- a method of recirculating energy in a stepper motor can include providing power at a power bus to a first output and to a second output, flowing power through a first electrical load electrically connected to the first output, switching a first switch to block power flow out of the first electrical load to a low electrical potential bus, switching a second switch to permit power from the power bus to flow from the second output, through a second electrical load electrically connected to the second output, to the low electrical potential bus, directing, by a first snubber circuit, power flow out of the first electrical load to the second output, switching the second switch to block power flow out of the second electrical load to the low electrical potential bus, switching the first switch to permit power from the power bus to flow from the first output, though the first electrical load, to the low electrical potential bus, and directing, by a second snubber circuit, power flow out of the second electrical load to the first output.
- the method can also include preventing backflow of current from the first snubber circuit to the power bus, and preventing backflow of current from the second snubber circuit to the power bus.
- the first snubber circuit can include a resistor and a diode in series electrical connection with the resistor, wherein directing, by the first snubber circuit, power flow out of the first electrical load to the second output can include permitting, by the diode, power flow from the first electrical load at a first input to the second output, and preventing, by the diode, power flow from the second output to the first input.
- the second snubber circuit can include a second resistor and a second diode in series electrical connection with the second resistor, wherein directing, by the second snubber circuit, power flow out of the second electrical load to the first output can include permitting, by the second diode, power flow from the second electrical load at a second input to the first output, and preventing, by the second diode, power flow from the first output to the second input.
- the first electrical load can include a first inductive electrical load
- the second electrical load can include a second inductive electrical load
- switching the first switch to permit power from the power bus to flow from the first output, though the first electrical load, to the low electrical potential bus can include energizing the first inductive electrical load
- switching the second switch to permit power from the power bus to flow from the second output, through a second electrical load electrically connected to the second output, to the low electrical potential bus can include energizing the second inductive electrical load.
- Power flow out of the first electrical load to the first output can at least partly include current flow caused by inductance of the first inductive load
- power flow out of the second electrical load to the second output can at least partly include current flow caused by inductance of the second inductive load.
- the first electrical load can include a first winding of a stepper motor
- the second electrical load can include a second winding of the stepper motor.
- Switching the first switch to permit power from the power bus to flow from the first output, though the first electrical load, to the low electrical potential bus can include energizing the first winding
- switching the second switch to permit power from the power bus to flow from the second output, through a second electrical load electrically connected to the second output, to the low electrical potential bus can include energizing the second winding.
- the method can also include controllably switching the first switch and the second switch to urge rotation of the stepper motor in a first direction, actuating, by the stepper motor, a tube clamp device configured to releasably receive a tube, and adjusting, based on the actuation, an amount of compression applied to the tube by the tube clamp device.
- an electrical drive system in another aspect, includes a first power output port configured to electrically connect to a first load input of a first electrical load, a first powur input port configured to electrically connect to a first load output of the first electrical load, a second power output port configured to electrically connect to a second load input of a second electrical load, a second power input port configured to electrically connect to a second load output of the second electrical load, a first snubber circuit in electrical communication between the first load input port and the second load output port, and a second snubber circuit in electrical communication between the second load input port and the first load output port.
- the first snubber circuit can include a first resistor and a first diode in series electrical connection with the first resistor, and the first diode is configured to pass current from the first load input port to the second load output port, and prevent current flow' from the second load output port to the first load input port
- the second snubber circuit can include a second resistor and a second diode in series electrical connection with the second resistor, and the second diode is configured to pass current from the second load input port to the first load output port, and prevent current flow' from the first load output port to the second load input port.
- the system can also include a power bus, a first diode configured to pass current from the power bus to the first load output port, and a second diode configured to pass current from the power bus to the second load output port.
- the system can also include a low electrical potential power bus, a first switch configured to controliabiy connect the first load input port to the low electrical potential power bus, and a second switch configured to controliabiy connect the second load input port to the low electrical potential power bus, and at least one resistor configured to limit current flow from the first load input port to the low' electrical potential power bus and to limit current flow' from the second load input port to the low el ectrical potential power bus.
- At least one of the first electrical load and the second electrical load can be an inductive electrical load.
- the first electrical load can be a first winding of a stepper motor
- the second electrical load can be a second winding of the stepper motor.
- the technology described this document can be used to provide one or more benefits.
- the stepper motor drive systems described herein cause stepper motors to exhibit a faster response, such as when accelerating to full speed.
- the time required for a stepper motor to reach full speed can about ten times faster using the stepper motor drive systems described herein as compared to current systems.
- stepper motor drive systems described herein are more energy efficient than current systems. In other words, the stepper motor drive systems described herein use less electrical energy than in current systems, and dissipate less energy as heat.
- stepper motor drive systems described herein are less electrically and mechanically noisy than current systems. In other words, the stepper motor drive systems described herein produce less current ripple, less torque ripple, have lower required working voltages and currents, and have improved electromagnetic compatibility'.
- FIG. 1 is a schematic diagram of patient undergoing open-heart surgery while being supported using an extracorporeal circuit in accordance with some embodiments provided herein.
- FIG. 2 illustrates a portion of a heart-lung-machine and a tube occluder device in accordance with some embodiments.
- FIG. 3 is a schematic diagram of a prior art stepper motor.
- FIG. 4 is a schematic diagram of a prior art motor driver circuit.
- FIG. 5 is a schematic diagram of an example motor driver circuit in accordance with some embodiments.
- FIGs. 6-8 are charts of example motor driver electrical waveforms in accordance with some embodiments.
- FIG. 9 is a flow diagram of an example process in accordance with some embodiments.
- stepper motor drive systems that can be used, for example, to drive a stepper motor of a tube occluder system and device in association with a heart-lung machine.
- the stepper motor drive systems described herein can also be beneficially used in many other contexts in which stepper motors are used.
- various types of medical procedures can be performed on a patient 10 while the patient 10 is connected to a life-sustaining heart/lung bypass machine system 100.
- the patient 10 is undergoing open-heart surgery during which the heart 12 and lungs of the patient 10 are temporarily intentionally caused to cease functioning.
- the heart/lung bypass machine system 100 performs such functions. That is, as described further below, the heart/lung bypass machine system 100 is connected to the patient 10 and performs the functions of th e heart 12 and lungs of the patient 10 so that the patient 10 stays alive and healthy during open-heart surgery.
- the heart/lung bypass machine system 100 can be used for many different types of medical procedures.
- the medical procedures for which the heart/lung bypass machine system 100 can be used include, but are not limited to, coronary artery bypass grafts, heart valve repairs, heart valve replacements, heart transplants, lung transplants, ablation procedures, repair of septal defects, repair of congenital heart defects, repair of aneurysms, pulmonary endarterectomy, pulmonary thrombectomy, and the like.
- the heart/lung bypass machine system 100 includes components and sub-systems such as a heart/lung machine 110, an extracorporeal circuit 120, one or more temperature control systems 130, a blood monitoring system 140, a perfusion data management system 150, and a regional oximetry system 160.
- a heart/lung machine 110 an extracorporeal circuit 120
- one or more temperature control systems 130 a blood monitoring system 140
- a perfusion data management system 150 a perfusion data management system
- a regional oximetry system 160 a regional oximetry system.
- the extracorporeal circuit 120 is connected to the patient 10, and to the heart/lung machine 110. Other systems, such as the temperature control system 130, the blood monitoring system 140, and the perfusion data management system 150 may also be arranged to interface with the extracorporeal circuit 120.
- the extracorporeal circuit 120 is connected to the patient 10 at the patient’s heart 12. Oxygen-depleted blood (venous blood) from the patient 10 is extracted from the patient 10 at the patient’s heart 12 using a venous catheter 121. As described further below, the blood is circulated through the extracorporeal circuit 120 to receive oxygen and remove carbon dioxide. The oxygenated blood is then returned through the extracorporeal circuit 120 to the patient’s heart 12 via an aortic cannula 129.
- the extracorporeal circuit 120 can include, at least, a venous tube 122 that is coupled to the venous catheter 121, a blood reservoir 123, a centrifugal pump 124, an oxygenator 125, an arterial filter 126, one or more air bubble detectors 128, and an arterial tube 127 that is coupled to the aortic cannula 129.
- the venous catheter 121 and venous tube 122 are in fluid communication with the venous side of the circulatory system of the patient 10.
- the venous tube 122 is also in fluid communication with an inlet to the reservoir 123.
- An outlet from the reservoir 123 is connected by tubing to an inlet of the pump 124.
- the outlet of the pump 124 is connected by tubing to an inlet of the oxygenator 125.
- the outlet of the oxygenator 125 is connected by tubing to an inlet of the arterial filter 126.
- An outlet of the arterial filter 126 is connected to the arterial tube 127.
- One or more pressure transducers can be located along the arterial tube 127 to detect a heart/lung machine (HLM) system line pressure of the blood in the arterial tube 127, which is measured by the heart/lung machine 110 and monitored by the perfusionist.
- the arterial tube 127 is connected to the aortic cannula 129, which is m physical contact with the heart 12 and in fluid communication with the arterial side of the circulatory' system of the patient 10.
- the extracorporeal circuit 120 operates by removing venous, oxygen- depleted blood from the patient 10 via the venous catheter 121, and depositing the venous blood in the reservoir 123 via the venous tube 122.
- gravity is used to cause the blood to flow or drain from the patient 10 to the reservoir 123.
- vacuum is used to assist the blood to flow from the patient 10 to the reservoir 123.
- At least some amount of blood is intended to be maintained in the reservoir 123 at all times during the surgical procedure. Otherwise, if the reservoir 123 becomes empty, air could be pumped into the extracorporeal circuit 120, and potentially into the vasculature of the patient 10. Such a result would likely be catastrophic for the patient 10.
- the perfusionist is tasked with visually monitoring the le vel of the blood in the reservoir 123.
- le vel detectors can he included in conjunction with the reservoir 123 to issue an alarm in response to detection of low-level conditions within the reservoir 123.
- one or more air bubble detectors 128 can be located at various sites along the extracorporeal circuit 120.
- Blood from the reservoir 123 is drawn from the reservoir 123 by the pump 124. While the depicted embodiment includes a one-time use centrifugal pump as the pump 124, in some cases a peristaltic pump of the heart/lung machine 110 is used instead. The pressure generated by the pump 124 propels the blood through the oxygenator 125.
- the perfusionist will adjust the pump 124 to operate as desired, while avoiding operational issues such as negative cavitation that could create micro air in the blood of the extracorporeal circuit 120.
- the venous blood is enriched with oxygen, and carbon dioxide is removed from the blood.
- the extracorporeal circuit 120 can also include tubing and other components for facilitating functions such as, but not limited to, drainage of blood accumulating in the heart of the patient 10, providing surgical suction for maintaining visibility of the surgical field, delivery of cardioplegia solution to the heart 12 of the patient 10 during the procedure, measuring blood parameters, removing air from the blood, hemoeoncentration, drug addition, obtaining blood samples, heating and cooling of the blood, and the like.
- the heart/lung bypass machine system 100 also includes the heart/lung machine 110.
- the heart/lung machine 110 is a complex system that includes multiple pumps, monitors, controls, user interfaces, alarms, safety devices, and the like, that are ail monitored and operated/adjusted by the perfusionist during a surgical procedure.
- the depicted heart/lung machine 110 includes an arterial pump 111 (which can be a drive system for a disposable centrifugal pump 124 as shown, or a peristaltic pump), a suction pump 112, a vent/drainage pump 113, a cardioplegia solution pump 114, and a cardioplegia delivery pump 115.
- the heart/lung machine 110 can also include, or be interfaced with, devices such as a tubing occluder, gas blender, and the like.
- the parameters of the heart/lung machine 110 such as the rotational speed and other parameters of each of the pumps, are set and adjusted by the perfusionist. For example, the speed of the arterial pump 111 is adjusted to maintain a desirable level of blood in the reservoir 123, and to provide a requisite level of blood circulation within the patient 10.
- the heart/lung bypass machine system 100 also includes one or more temperature control systems 130.
- the temperature control system(s) 130 is/are used to heat and cool the patient ' s blood in the oxygenator 125 via a heat exchanger. Additionally, the temperature control system(s) 130 is/are used to heat and cool the cardioplegia solution being delivered to the heart 12 of the patient 10.
- the temperature control system(s) 130 is/are used in cooling modes during the procedure (to reduce metabolic demands), and subsequently used to warm the blood and/or cardioplegia solution when the surgical procedure is nearing its end. The perfusionist is tasked with monitoring and adjusting the temperature control system(s) 130 as needed during the surgical procedure.
- the heart/lung bypass machine system 100 also includes the blood monitoring system 140.
- the blood monitoring system 140 is used to monitor the extracorporeal blood of the patient 10 during the surgical procedure. Parameters being monitored can include, but are not limited to, pH, pCO 2 , pO 2 , K+, temperature, SO 2 , hematocrit, hemoglobin, base excess, bicarbonate, oxygen consumption and oxygen delivery .
- the heart/lung bypass machine system 100 also includes the perfusion data management system 150 and the regional oximetry system 160. These systems can also be used by the perfusionist to monitor the status of the patient 10 and/or the status of the heart/lung bypass machine system 100 during surgical procedures.
- the heart/lung bypass machine system 100 also includes an occluder device 170 (e.g., a tube occluder system).
- the occluder device 170 is located along the venous tube 122.
- the occluder device 170 can be located along the arterial tube 127 or any other tube of the heart/lung bypass machine system 100.
- the occluder device 170 applies an external clamping force to the outer diameter of the tube to modulate a flow rate of the fluid flowing in the tube, in some cases, the occluder device 170 is used as a shut-off device that can be activated to occlude the tube completely, thereby preventing all flow of fluid through the tube.
- the occluder device 170 is shown as being mounted to the heart/lung machine 110.
- the occluder device 170 includes an occluder housing 172, a drive system housing 174, and a user interface 176.
- the occluder housing 172 is configured to releasably receive a tube (in tins example the tube is venous tube 122). Within the occluder housing 172 is a clamp mechanism (not visible) that compresses the outer diameter of the tube 122 and a stepper motor (not visible) that drives the clamp mechanism.
- the stepper motor can be operated to ad just a controlled amount of compression applied to the tube 122 to modulate the flow of fluid through the tube 122.
- stepper motor drive system (not visible) that is electrically coupled to the stepper motor.
- the stepper motor drive system is described further below.
- the occluder device 170 also includes the user interface 176.
- the user e.g., perfusionist
- the user can adj ust the flow rate of the fluid in the tube 122 via the user interface 176.
- FIG. 3 a schematic diagram of an example stepper motor 300 is shown.
- the stepper motor 300 includes a rotor 310, a phase 320a, and a phase 320b.
- the stepper motor 300 is an eight-wire unipolar stepper motor, in which the phase 320a includes a winding 322a and a winding 324a, and the phase 320b includes a winding 322b and a winding 324b.
- each of the coils 322a, 322b, 324a, and 324b has a coil input and a coil output
- unipolar stepper motors have one winding per phase, each with a center tap, and each section of the windings can be energized for each direction of magnetic field.
- the center tap of each winding is made common, which results in three leads per phase and six leads total (e.g., for a two phase motor).
- the two center taps can be internally joined, resulting in a five- ware configuration.
- the stepper motor 300 can be a bipolar stepper motor, with a single coil per phase.
- the windings 322a, 322b, 324a, and 324b of the phases 320a and 320b can be control! ably energized and de-energized (e.g., raider control of a motor controller), to urge rotation of the rotor 310.
- an electrical coil such as each of the windings 322a, 322b, 324a, and 324b, does not flow current instantaneously. Rather, the current flow starts relatively slowly and builds to its maximum flow' as the magnetic fields generated by the current flow through the coil build to their maximum. Conversely, current flow' through a coil does not stop instantaneously when the coil is de-energized. The collapsing magnetic field will continue to urge current flow' until it falls to zero.
- FIG. 4 a schematic diagram of a prior art motor driver circuit 400 is shown.
- the circuit 400 is configured to drive a winding 401a and a winding 401b of a stepper motor.
- the winding 401a and the winding 401b can be all or part of the example phase 320a or the phase 320b of the example stepper motor 300 of FIG. 3.
- the winding 401a includes a coil 402a and a resistor 403a.
- the coil 402a can model the inductance of the winding 401a.
- the resistor 403a can model the inherent DC resistance of the winding 401a.
- the winding 401b includes a coil 402b and a resistor 403b.
- the coil 402b can model the inductance of the winding 401b.
- the resistor 403b can model the inherent DC resistance of the winding 401b.
- the coil 402a is part of an electromagnet that drives a winding of the stepper motor
- the coil 402b is part of an electromagnet that drives another winding of the stepper motor.
- DCR winding resistance
- a power supply 410 provides power to a power bus 412.
- the power bus 412 provides power to the winding 401a and the winding 401b.
- Electrical current flow from the power bus 412 though the winding 401a to a low' electrical potential bus 420 e.g., ground, neutral, negative
- a switch 430a based on control signals provided to a switch input 432a.
- Electrical current flow from the power bus 412 though the winding 401 b to the low electrical potential bus 420 is controllably blocked and permitted by a switch 430b,
- the switches 430a and 430b are MGSFET devices.
- the windings 401a and 401b can be energized and de-energized to urge rotation of the stepper motor.
- curren t flow' through a coil does not s top instantaneously when power is switched off. Instead, there is a residual current flow that is induced by the collapsing magnetic fields around the coii(s). in the illustrated example, such currents can cause voltage spikes across the switches 430a and 430b, and such voltage spikes can damage the switches 430a and 430b (e.g., due to electrical arcing) if not accounted for with a snubber circuit 450.
- the snubber circuit 450 is a known snubber circuit configuration.
- the switch 430a When the switch 430a is shut off. residual current from the winding 401a is prevented from flowing to the low' electrical potential bus 420.
- the residual current of the winding 401a is able to flow' from the winding 401a back to the pow'er bus 412 through a diode 452a and a current dissipating resistor 454.
- the diode 452a prevents current from the pow'er bus 412 from bypassing the winding 401a.
- the switch 430b When the switch 430b is shut off, residual current from the winding 401b is prevented from flowing to the low electrical potential bus 420.
- the residual current of the winding 401b is able to flow' from the winding 401b back to the power bus 412 through a diode 452b and the current dissipating resistor 454.
- the diode 452b prevents current from the power bus 412 from bypassing the winding 401b.
- the residual energy that flows through the snubber circuit 450 is dissipated (e.g., turned into heat) by the current dissipating resistor 454.
- the residual energy is lost through the dissipation, and can have unwanted effects, such as the generation of heat.
- the speed at which the coils 402a, 402b is proportional to the amount of power available at the power bus 412. For example, if the coils 402a, 402b need to be energized more quickly (e.g., for greater assurance that the stepper motor 300 will not stall, to create less current and/or torque ripple), the output of the power supply 410 would need to be increased (e.g., resulting in increased size, cost, weight of the circuit 400), and as the amount of power being switched by the switches 430a, 430b increases, the amount of electromagnetic interference (EMI) (e.g., switching noise) can increase, and may need to be addressed depending on the application (e.g., further increasing the size, cost, and complexity of the circuit 400).
- EMI electromagnetic interference
- FIG. 5 a schematic diagram of an example motor driver circuit 500 is shown, in accordance with some embodiments disclosed herein.
- the circuit 500 is configured to drive a winding 501 a and a winding 501b of a stepper motor.
- the winding 501a and the winding 501b can be analogous to any two of the example windings 322a, 322b, 324a, and t 324b of the example stepper motor 300 of FIG. 3.
- the winding 501a includes a coil 502a and a resistor 503a.
- the coil 502a can model the inductance of the winding 501 a.
- the resistor 503a can model the inherent DC resistance of the winding 501a
- the winding 501b includes a coil 502b and a resistor 503b.
- the coil 502b models the inductance of the winding 501b.
- the resistor 503b can model the inherent DC resistance of the winding 501b.
- Tire coil 502a is part of an electromagnet that drives a motor winding of a stepper motor (e.g., the example stepper motor 300), and the coil 502b is part of air electromagnet that drives another motor winding of the same phase or a different phase of the stepper motor.
- a stepper motor e.g., the example stepper motor 300
- the coil 502b is part of air electromagnet that drives another motor winding of the same phase or a different phase of the stepper motor.
- a load input port. 504a is configured to receive electrical power into the winding 501 a, and a load output port 506a is configured to permit electrical power to flow out of the winding 501a.
- the load input port 504a is a stepper motor winding input port or input lead wire
- the load output port 506a is a stepper motor winding output port or output lead wire.
- a power supply 510 provides power to a power bus 512.
- the power bus 512 provides power to a load output port 514a and a load output port 514b.
- the load output port 514a is configured to connect to the load input port 504a electrically
- the load output port 514b is configured to connect to the load input port 504b electrically.
- a load input port 516a is configured to electrically connected to the load output port 506a to receive power flowing out from the winding 501a.
- a load input port 516b is configured to electrically connected to the load output port 506b to receive power flowing out from the winding 501b.
- Current backflow' to the power bus 512 is blocked by a diode 518a arranged between the load output port 514a and the power bus 512,
- Current backflow' to the power bus 512 from the winding 501a is blocked by a diode 518a arranged between the load output port 514a and the power bus 512.
- the diodes 518a, 518b can be omitted, for example, when the power supply 510 is a unidirectional power supply.
- the diodes 518a and 518b can replaced by a single diode, e.g., in the case of a 6-leaded stepper motor, where the power supply is bidirectional.
- the diodes 518a and 518 b can be removed in the case of a 6-leaded stepper motor, e.g., if the power supply is unidirectional, in some embodiments in which an 8-leaded stepper motor is used, the diodes 518a and 518b can both be used, regardless of whether the power supply 410 is unidirectional and/or bidirectional.
- the circuit 500 includes a low electrical potential bus 520.
- the low electrical potential bus 520 is a ground bus, but in some embodiments the low electrical potential bus 520 can include a neutral line, a negative (e.g., return) line, or can be at any appropriate voltage that is less than the voltage of the power bus 512.
- switches 530a and 530b are MOSFET devices, but in some embodiments the 530a and 530b the switches can be any appropriate form of controllable switch that can control current flow' though the windings 501 a and 501b (e.g., FETs, lGBTs, BJTs, or other forms of transistors, relays).
- a current-limiting resistor 522 limits current flow to the low-potential bus.
- the windings 501a and 501b can be energized and de-energized to urge rotation of the stepper motor.
- current flow through a coil does not stop instantaneously when power is switched off; there is a residual current flow that is induced by the collapsing magnetic fields around the coil(s) 502a, 502b.
- such currents that could otherwise cause voltage spikes across the switches 530a and 530b (and possibly damage the switches 530a and 530b due to electrical arcing, for example) are accounted for with a snubber circuit 550.
- the snubber circuit includes a branch 551a and a branch 551b.
- the branch 551a provides electrical communication between the load input port 516a to the load output port 514b.
- the branch 551a includes a diode 552a in series connection with a current limiting resistor 554a.
- the diode 552a is configured to permit current flow from the load input port 516a to the load output port 514b, and prevent current flow from the load output port 514b to the load input port 516a.
- the branch 551b provides electrical communication between the load input port 516b to the load output port 514a.
- the branch 551b includes a diode 552b in series connection with a current limiting resistor 554b.
- the diode 552b is configured to permit current flow from the load input port 516b to the load output port 514a, and prevent current flow from the load output port 514a to the load input port 516b.
- the switch 530a is turned on and the winding 501a becomes energized, while the swatch 530b is off. The switch 530a is then turned off. A residual current will be pushed out of the coil 502a. Backflow of this residual current is blocked by the diode 518a and the diode 552b. Forward flow of this residual current is blocked by the switch 530a, leaving the branch 551a as the only electrical path where the residual current can flow. As the coil 502a de-energizes, the residual current flows though the branch 551a to the load output port 514b. The diode 518b prevents current backflow to the power bus 512, so the current flows into the winding 501b to the coil 502b.
- the residual current created as the coil 502a de-energizes is used to energize the coil 502b to at least a partial degree.
- the snubber circuit 550 can recapture the energy of the coil 502a (e.g., rather than dissipate it) and use that recaptured energy, along with power from the power bus 512, to energize the coil 502b more quickly than it could be energized based on power from the power bus 512 alone.
- the switch 530b is turned on and the winding 501b becomes energized, and the switch 530a is turned off. The switch 530b is then turned off. A residual current will be pushed out of the coil 502b. Backflow of this residual current is blocked by the diode 518b and the diode 552a. Forward flow of this residual current is blocked by the switch 530b, leaving the branch 551b as the only electrical path where the residual current can flow'. As the coil 502b de- energizes, the residual current flows though the branch 551b to the load output port. 514a.
- the diode 518a prevents current backflow to the power bus .512, so the current flows into the winding 501a to the coil 502a.
- the residual current created as the coil 502b de-energizes is used to energize the coil 502a to at least a partial degree.
- the snubber circuit 550 can recapture the energy of the coil 502b (e.g., rather than dissipate it) and use that recaptured energy, along with power from the power bus 512, to energize the coil 502a more quickly than it could be energized based on power from the power bus 512 alone.
- the coils 502a, 502b by redirecting residual energy from the coils 502a, 502b to their counterpart coil, energy efficiency can be increased. For example, at least a portion of the residual coil energy can be reused instead of being entirely dissipated.
- the circuit 500 does not implement a current dissipating resistor such as the current dissipating resistor 4.54 of FIG, 4. which dissipates residual coil energy as heat. Since the circuit 500 substantially recycles coil energy, rather than substantially dissipate the energy as heat, the thermal management associated with such heat generation is substantially reduced.
- the circuit 500 can be implemented efficiently (e.g., more efficiently than the example circuit 400).
- the capacity of the power supply 410 and/or the power bus 412 would need to be increased, which could increase the size, weight, cost, and/or complexity of the circuit 400.
- the circuit 500 is configured to use residual energy from one of the coils 502a, 502b in addition to power from the power bus 512 to energize the other one of the coils 502a, 502b. As such, the performance of the coils 502a,
- the stepper motor 502b can be increased (e.g., for greater assurance that the stepper motor will not stall, to create less current and/or torque ripple) without the size, weight, cost, and/or complexity that may be associated with achieving similar performance increases by increasing the capacity of the power supply 510 and/or the power bus 512.
- EMI electromagnetic interference
- residual energy in the coils 502a, 502b is redirected away from the switches 530a, 530b relatively more quickly than in the circuit 400, resulting is relatively lower voltages across the switches 530a, 530b.
- the relatively lower voltages provided by the snubber circuit 550 can result in relatively lower amounts of EMI (e.g., switching noise) caused by switching of the switches 530a, 530b, relative to the circuit 400.
- FIGs. 6-8 are charts of example motor driver electrical waveforms.
- FIG. 6 is a chart 600 that shows an example of a current waveform 610 that can be produced by the example circuit 500 of FIG, 5.
- FIG. 6 also shows an example of a current waveform 620 that can be produced by known circuits, such as the circuit 400 of FIG. 4.
- both of the waveform 610 and the waveform 620 have roughly the same start-up behavior, since there is no energy stored in their respective motor coils yet. After the first coils stores energy, the effect of the energy recirculation can be observed the waveform 610 rising faster than the waveform 620, and with less ripple. In the illustrated example, both cases had the same 24v supply voltage.
- the faster rise times of the waveform 610 are due to the energy stored in the coils being transferred quickly to the complementary coil during switching edges, which allows the coils (or windings or inductances) to have more initial energy and therefore be further along in the first-order 1-e -t /tau curve, and therefore exhibit less current ripple.
- FIG. 7 is a chart 700 that shows another example of a current waveform 710 that can be produced by the example circuit 500 of FIG. 5.
- FIG. 7 also shows an example of a current waveform 720 that can be produced by known circuits, such as the circuit 400 of FIG. 4.
- the chart 700 shows example of the ripple currents after the supply voltages (e.g., of the power bus 412 and 512) have been adjusted to match peak current values (e.g., at the end of the on-time cycles), as represented by line 730.
- the waveform 710 has a ripple of about 141 mA, as measured between initial current values represented by line 732, and the peak current values 730.
- the waveform 720 has a ripple of about 1.57A between initial current values represented by line 734, and the peak current values 730.
- the ripple of the example circuit 500 exhibits ripple that is a factor of about 11x less than the ripple exhibited by the known circuit 400.
- the factor of ripple reduction provided by the circuit 500 can be be even greater.
- FIG, 8 is a chart 800 that shows another example of a current waveform pair 810 that can be produced by the example circuit 500 of FIG. 5.
- FIG. 8 also shows an example of a current waveform pair 820 that can be produced by known circuits, such as the circuit 400 of FIG, 4.
- the current waveform pair 810 includes a waveform 812a and a waveform 812b.
- the waveforms 812a and 812b can represent example currents of windings within a motor phase (e.g., for the purpose of more clearly illustrating the reduced ripple provided by the circuit 500).
- the waveform 812a can be an example of the current waveform across the example winding 501a
- the waveform 812b can be an example of the curreni waveform across the example winding 501b
- the current waveform pair 820 includes a waveform 822a and a waveform 822b.
- the waveform 822a can be an example of the current waveform across the example winding 401a
- the waveform 822b can be an example of the current waveform across the example winding 401b.
- the chart 800 illustrates an example improvement in ripple and energy transfer provided by the circuit 500 when compared to the circuit 400.
- FIG, 9 is a flow diagram of an example process 900 in accordance with some embodiments.
- the process 900 can be performed by the example circuit 500 of FIG. 5.
- power is provided at a power bus to a first output and to a second output.
- power can be provided by the power supply 510 at the power bus 512 to the load output port 514a and the load output port 514b,
- a first switch is switched to block power flow out of the first electrical load to a low electrical potential bus.
- the switch 530a can be switched off to stop the power flowing out from the winding 501a to the low electrical potential bus 520.
- a second switch is switched to permit power from the power bus to flow from the second output, through a second electrical load electrically connected to the second output, to the low electrical potential bus.
- the swatch 530b can be switched on to permit power from the power bus 512 to flow through the winding 501b to the low electrical potential bus 520.
- a first snubber circuit directs pow'er flow ' out of the first electrical load to the second output.
- the branch 551a of the snubber circuit 550 conducts residual energy flowing in though the load input port 516a and blocked by the swatch 530a, to the load output port 514b.
- the first snubber circuit can include a resistor and a diode in series electrical connection with the resistor.
- the branch 551 a includes the diode 552a and the current limiting resistor 554a.
- directing, by the first snubber circuit, power flow out of the first electrical load to the second output can include permitting, by the diode, power flow from the first electrical load at a first input to the second output, and preventing, by the diode, power flow from the second output to the first input.
- the diode 552a can permit one-way current flow from the load input port 516a to the load output port 514b.
- the second switch is switched to block power flow out of the second electrical load to the low electrical potential bus.
- the switch 530b can be switched to block power flowing in through the load input port 516b from flowing to the low 7 electrical potential bus 520.
- the first switch is switched to permit power from the power bus to flow from the first output, though the first electrical load, to the low electrical potential bus.
- the switch 530a is switched to permit power to flow from the load input port 516a to the low electrical potential bus 520.
- a second snubber circuit directs power flow out of the second electrical load to the first output.
- the branch 551b of the snubber circuit 550 conducts residual energy' flowing in though the load input port 516b and blocked by the switch 530b, to the load output port 514a.
- power flow out of the first electrical load to the first output can at least partly be current flow caused by inductance of the first inductive load
- power flow' out of the second electrical load to the second output can at least partly be current flow caused by inductance of the second inductive load.
- the first snubber circuit can include a resistor and a diode in series electrical connection with the resistor.
- the branch 551b includes the diode 552b and the current limiting resistor 554b.
- directing, by the second snubber circuit, power flow out of the second electrical load to the first output can include permitting, by the diode, power flow from the second electrical load at a second input to the first output, and preventing, by the diode, power flow from the first output to the second input.
- the diode 552b can permit one-way current flow from the load input port 516b to the load output port 514a.
- tire process 900 can also include preventing backflow of current from the first snubber circuit to the power bus, and preventing backflow of current from the second snubber circuit to the power bus.
- the diodes 518a and 518b can pre vent backflow of power from the snubber circuit 550 to the power bus 512.
- the first electrical load can be a first inductive electrical load
- the second electrical load can be a second inductive electrical load
- the winding 501a is an electrical load that includes the coil 502a, which is an inductive electrical load
- the winding 501b is an electrical load that includes the coil 502b, winch is another inductive electrical load.
- switching the first switch to permit power from the power bus to flow from the first output, through a first electrical load electrically connected to the first output, to the low electrical potential bus can include energizing the first inductive electrical load. For example, when current flows through the winding 501a, the coil 502a can become energized.
- switching the second switch to permit power from the power bus to flow' from the second output, through a second electrical load electrically connected to the second output, to the low electrical potential bus can include energizing the second inductive electrical load. For example, when current flows through the winding 501b, the coil 502b can become energized.
- the first electrical load can be a first winding of a stepper motor
- the second electrical load can be a second winding of the stepper motor.
- the winding 501a can he all or part of the winding 320a of the stepper motor 300
- the winding 501b can be all or part of the winding 320b.
- switching the first switch to permit power from the power bus to flow from the first output, though the first electrical load, to the low electrical potential bus can include energizing the first winding
- switching the second switch to permit power from the power bus to flow from the second output, through a second electrical load electrically connected to the second output, to the low electrical potential bus can include energizing the second winding.
- the switches 530a and 530b can be switched to energize the windings 501a and 501b, which can be the windings 320a and 320b.
- the process 900 can also include controllably switching the first swatch and the second switch to urge rotation of the stepper motor in a first direction, actuating, by the stepper motor, a tube clamp device configured to releasably receive a tube, and adjusting, based on the actuation, an amount of compression applied to the tube by the tube clamp device.
- the example circuit 500 can be used to actuate the example stepper motor 300 of FIG. 3, which can be configured to actuate the example occluder device 170 of FIGs. 1 and 2.
- the stepper motor 300 can be operated to control an amount of compression applied to the tube 122, and thereby modulate the flow of fluid through the tube 122.
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- Power Engineering (AREA)
- Mechanical Engineering (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Pulmonology (AREA)
- Control Of Stepping Motors (AREA)
- External Artificial Organs (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP21748065.6A EP4096753A4 (en) | 2020-01-30 | 2021-01-12 | Stepper motor drive systems and tubing occluder system |
JP2022544762A JP7423796B2 (en) | 2020-01-30 | 2021-01-12 | Stepping motor drive system and tubing occluder system |
AU2021213045A AU2021213045A1 (en) | 2020-01-30 | 2021-01-12 | Stepper motor drive systems and tubing occluder system |
JP2023163192A JP2023179567A (en) | 2020-01-30 | 2023-09-26 | Stepping motor drive system and tubing occluder system |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16/777,533 US11724098B2 (en) | 2020-01-30 | 2020-01-30 | Stepper motor drive systems and tubing occluder system |
US16/777,533 | 2020-01-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2021154491A1 true WO2021154491A1 (en) | 2021-08-05 |
Family
ID=77061323
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2021/013094 WO2021154491A1 (en) | 2020-01-30 | 2021-01-12 | Stepper motor drive systems and tubing occluder system |
Country Status (5)
Country | Link |
---|---|
US (1) | US11724098B2 (en) |
EP (1) | EP4096753A4 (en) |
JP (2) | JP7423796B2 (en) |
AU (1) | AU2021213045A1 (en) |
WO (1) | WO2021154491A1 (en) |
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-
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- 2020-01-30 US US16/777,533 patent/US11724098B2/en active Active
-
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- 2021-01-12 EP EP21748065.6A patent/EP4096753A4/en active Pending
- 2021-01-12 AU AU2021213045A patent/AU2021213045A1/en active Pending
- 2021-01-12 JP JP2022544762A patent/JP7423796B2/en active Active
- 2021-01-12 WO PCT/US2021/013094 patent/WO2021154491A1/en unknown
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US5231342A (en) | 1989-05-31 | 1993-07-27 | Kabushikigaisha Sekogiken | Stepping motor |
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US20040062060A1 (en) * | 2002-09-27 | 2004-04-01 | Yokogawa Electric Corporation | Switching power supply and distributed parameter structure |
US20060025725A1 (en) * | 2004-05-28 | 2006-02-02 | Cassidy David E | Gas removal in an intravenous fluid delivery system |
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Title |
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See also references of EP4096753A4 |
Also Published As
Publication number | Publication date |
---|---|
US11724098B2 (en) | 2023-08-15 |
JP7423796B2 (en) | 2024-01-29 |
JP2023179567A (en) | 2023-12-19 |
EP4096753A4 (en) | 2023-10-18 |
AU2021213045A1 (en) | 2022-06-16 |
JP2023523495A (en) | 2023-06-06 |
US20210236704A1 (en) | 2021-08-05 |
EP4096753A1 (en) | 2022-12-07 |
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