WO2021137561A3 - 4-헥실레소르시놀을 유효성분으로 포함하는 골질환 예방 또는 치료용 약학조성물 - Google Patents

4-헥실레소르시놀을 유효성분으로 포함하는 골질환 예방 또는 치료용 약학조성물 Download PDF

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Publication number
WO2021137561A3
WO2021137561A3 PCT/KR2020/019227 KR2020019227W WO2021137561A3 WO 2021137561 A3 WO2021137561 A3 WO 2021137561A3 KR 2020019227 W KR2020019227 W KR 2020019227W WO 2021137561 A3 WO2021137561 A3 WO 2021137561A3
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WO
WIPO (PCT)
Prior art keywords
hexylresorcinol
active ingredient
prevention
bone
treatment
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PCT/KR2020/019227
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English (en)
French (fr)
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WO2021137561A2 (ko
Inventor
최제용
차상국
김현주
이동교
김성곤
김한
Original Assignee
경북대학교 산학협력단
강릉원주대학교산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from KR1020200154564A external-priority patent/KR20210086463A/ko
Application filed by 경북대학교 산학협력단, 강릉원주대학교산학협력단 filed Critical 경북대학교 산학협력단
Priority to CN202080091021.2A priority Critical patent/CN114980872A/zh
Priority to US17/790,132 priority patent/US20230049524A1/en
Publication of WO2021137561A2 publication Critical patent/WO2021137561A2/ko
Publication of WO2021137561A3 publication Critical patent/WO2021137561A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

본 발명은 본 발명은 4-헥실레소르시놀(4-hexylresorcinol, 4-HR)를 유효성분으로 포함하는 골질환의 예방 또는 치료용 조성물 및 이의 제형에 관한 것으로, 상기 4-헥실레소르시놀(4-hexylresorcinol, 4-HR)을 유효성분으로 함유하는 조성물 또는 연고제는 골다공증이 유도된 동물모델에서 골의 두께, 밀도 및 강도를 개선하고, 조골세포의 분화를 촉진하고 파골세포의 증식과 분화를 억제하여 골 재형성을 조절하는 것이 확인됨에 따라, 상기 4-헥실레소르시놀(4-hexylresorcinol, 4-HR)을 유효성분으로 포함하는 조성물 또는 연고제는 골절, 골관절염, 류마티스 관절염 및 골다공증을 포함하는 골질환의 치료제로 제공될 수 있다.
PCT/KR2020/019227 2019-12-30 2020-12-28 4-헥실레소르시놀을 유효성분으로 포함하는 골질환 예방 또는 치료용 약학조성물 WO2021137561A2 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202080091021.2A CN114980872A (zh) 2019-12-30 2020-12-28 包含4-己基间苯二酚作为活性成分的用于预防或治疗骨疾病的药物组合物
US17/790,132 US20230049524A1 (en) 2019-12-30 2020-12-28 Pharmaceutical composition comprising 4-hexylresorcinol as active ingredient for prevention or treatment of bone disease

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2019-0178187 2019-12-30
KR20190178187 2019-12-30
KR10-2020-0154564 2020-11-18
KR1020200154564A KR20210086463A (ko) 2019-12-30 2020-11-18 4-헥실레소르시놀을 유효성분으로 포함하는 골질환 예방 또는 치료용 약학조성물

Publications (2)

Publication Number Publication Date
WO2021137561A2 WO2021137561A2 (ko) 2021-07-08
WO2021137561A3 true WO2021137561A3 (ko) 2021-08-26

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PCT/KR2020/019227 WO2021137561A2 (ko) 2019-12-30 2020-12-28 4-헥실레소르시놀을 유효성분으로 포함하는 골질환 예방 또는 치료용 약학조성물

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WO (1) WO2021137561A2 (ko)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060120975A1 (en) * 2004-12-02 2006-06-08 Colgate-Palmolive Company Oral care composition comprising a phenolic compound and antioxidant vitamins and vitamin derivatives
US20080286377A1 (en) * 2001-11-20 2008-11-20 Sloan-Kettering Institute For Cancer Research Anti-resorptive bone cements and allogeneic, autografic, and xenografic bone grafts
KR20110050308A (ko) * 2009-11-06 2011-05-13 이용찬 ４―헥실레조르시놀（ｈｅｘｙｌｒｅｓｏｒｃｉｎｏｌ）을 포함하는 치과용 골 이식재 및 이를 이용한 임플란트 코팅
KR20160028824A (ko) * 2014-09-04 2016-03-14 강릉원주대학교산학협력단 소수성 소재 간 상호 작용을 이용한 4-헥실레조르시놀의 이식재 내 투입 기술
KR102056463B1 (ko) * 2019-05-29 2019-12-17 주식회사 멘티스로지텍 골 형성에 영향을 미치는 4-헥실레조르시놀을 접목한 골 이식재

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080286377A1 (en) * 2001-11-20 2008-11-20 Sloan-Kettering Institute For Cancer Research Anti-resorptive bone cements and allogeneic, autografic, and xenografic bone grafts
US20060120975A1 (en) * 2004-12-02 2006-06-08 Colgate-Palmolive Company Oral care composition comprising a phenolic compound and antioxidant vitamins and vitamin derivatives
KR20110050308A (ko) * 2009-11-06 2011-05-13 이용찬 ４―헥실레조르시놀（ｈｅｘｙｌｒｅｓｏｒｃｉｎｏｌ）을 포함하는 치과용 골 이식재 및 이를 이용한 임플란트 코팅
KR20160028824A (ko) * 2014-09-04 2016-03-14 강릉원주대학교산학협력단 소수성 소재 간 상호 작용을 이용한 4-헥실레조르시놀의 이식재 내 투입 기술
KR102056463B1 (ko) * 2019-05-29 2019-12-17 주식회사 멘티스로지텍 골 형성에 영향을 미치는 4-헥실레조르시놀을 접목한 골 이식재

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