WO2021134474A1 - 样本分析系统及方法 - Google Patents

样本分析系统及方法 Download PDF

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Publication number
WO2021134474A1
WO2021134474A1 PCT/CN2019/130499 CN2019130499W WO2021134474A1 WO 2021134474 A1 WO2021134474 A1 WO 2021134474A1 CN 2019130499 W CN2019130499 W CN 2019130499W WO 2021134474 A1 WO2021134474 A1 WO 2021134474A1
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WIPO (PCT)
Prior art keywords
sample
analysis
mode
blood
smear
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PCT/CN2019/130499
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English (en)
French (fr)
Inventor
叶波
邢圆
罗玮
余珊
陈巧妮
祁欢
Original Assignee
深圳迈瑞生物医疗电子股份有限公司
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Application filed by 深圳迈瑞生物医疗电子股份有限公司 filed Critical 深圳迈瑞生物医疗电子股份有限公司
Priority to PCT/CN2019/130499 priority Critical patent/WO2021134474A1/zh
Priority to CN201980103095.0A priority patent/CN114829944A/zh
Publication of WO2021134474A1 publication Critical patent/WO2021134474A1/zh

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system

Definitions

  • the present invention relates to medical equipment technology, in particular to a sample analysis system and method.
  • Hematology analyzers are an instrument that can detect cells in blood samples and body fluid samples, such as white blood cells (WBC), red blood cells (RBC), platelets (PLT), and nuclear Cells such as red blood cells and reticulocytes are tested to determine whether the cells in blood samples and body fluid samples are abnormal. If the cell detection result is abnormal, push and stain the sample with abnormal detection result to obtain a sample smear, and then use a microscope to perform manual microscopy or use a cell image analysis device (such as a film reader) to image the sample smear. analysis.
  • WBC white blood cells
  • RBC red blood cells
  • PHT platelets
  • nuclear Cells such as red blood cells and reticulocytes
  • the cell image analysis device needs to specify the operation mode of the cell image analysis device before taking and analyzing the image of the sample smear.
  • the operation mode of the cell image analysis device is specified as shown in Figure 1.
  • the display area displays the mode designation interface.
  • the user selects the analysis mode corresponding to the current sample smear as the operation mode of the cell image analysis device, and then the cell image analysis device performs image capture and analysis in the selected operation mode.
  • the types of abnormalities in the smears of each sample are not the same. Reading the smears in a preset and unified mode, to a certain extent, causes the accuracy of the analysis results to be low.
  • the operating mode of the cell image analysis device is manually set for each sample smear, the processing efficiency of the cell image analysis device is not high.
  • the embodiment of the present invention provides a sample analysis system and method to automatically determine the operating mode of the cell image analysis device, and improve processing efficiency and accuracy of processing results.
  • an embodiment of the present invention provides a sample analysis system, including:
  • Hematology analyzer used for testing the sample to be tested to obtain test result information
  • a smear preparation device for preparing a sample smear of the sample to be tested
  • a cell image analysis device which is used for image capture and analysis of the sample smear prepared by the smear preparation device
  • the transport device includes a first transport track and a second transport track.
  • the first transport track is used to transport the sample to be tested from the blood cell analyzer to the smear preparation device
  • the second transport track is used to transport the sample to the smear preparation device.
  • the sample smear is transported from the smear preparation device to the cell image analysis device;
  • a sample information acquisition device for acquiring sample information of the sample to be tested
  • the control device is in communication connection with the blood cell analyzer, the smear preparation device, the cell image analysis device, the transport device, and the sample information acquisition device, and is configured to:
  • control the first transport track to transport the sample to be tested to the smear preparation device, so that the smear preparation device prepares a sample smear of the sample to be tested ;
  • the cell image analysis device is controlled to perform image capture and analysis of the sample smear in the operating mode.
  • an embodiment of the present invention provides a sample analysis system, including:
  • Hematology analyzer used for testing the sample to be tested to obtain test result information
  • a smear preparation device for preparing a sample smear of the sample to be tested
  • a cell image analysis device which is used for image capture and analysis of the sample smear prepared by the smear preparation device
  • the transport device includes a first transport track and a second transport track.
  • the first transport track is used to transport the sample to be tested from the blood cell analyzer to the smear preparation device
  • the second transport track is used to transport the sample to the smear preparation device.
  • the sample smear is transported from the smear preparation device to the cell image analysis device;
  • the control device is in communication connection with the blood cell analyzer, the smear preparation device, the cell image analysis device, and the transport device, and is configured to:
  • the detection result information of the sample to be tested from the blood cell analyzer, and when the detection result information meets a predetermined condition, control the first transport track to transport the sample to be tested to the smear preparation device , So that the smear preparation device prepares a sample smear of the sample to be tested;
  • the cell image analysis device is controlled to perform image capture and analysis of the sample smear in the operating mode.
  • an embodiment of the present invention provides a sample analysis system, including:
  • Hematology analyzer used for testing the sample to be tested to obtain test result information
  • a smear preparation device for preparing smears of the sample to be tested
  • a cell image analysis device which is used for image capture and analysis of the sample smear prepared by the smear preparation device
  • the transport device includes a first transport track and a second transport track.
  • the first transport track is used to transport the sample to be tested from the blood cell analyzer to the smear preparation device
  • the second transport track is used to transport the sample to the smear preparation device.
  • the sample smear is transported from the smear preparation device to the cell image analysis device;
  • the control device is in communication connection with the blood cell analyzer, the smear preparation device, the cell image analysis device, and the transport device, and is configured to:
  • the mode designation interface is displayed;
  • the mode selection instruction being used to instruct a user to select an operating mode of the cell image analysis device from the mode designation interface;
  • the cell image analysis device is controlled to call the selected operating mode to perform image capture and analysis of the sample smear.
  • an embodiment of the present invention provides a sample analysis method, including:
  • the control device determines the operation mode of the cell image analysis device from the preset analysis mode set according to the acquired at least one kind of information
  • the cell image analysis device is made to call the operating mode to perform image shooting and analysis of the sample smear of the sample to be tested prepared by the smear preparation device.
  • the sample analysis system includes: a blood cell analyzer, a smear preparation device, a cell image analysis device, a transport device, a sample information acquisition device, and a control device.
  • the control device is configured to obtain a sample from the blood cell analyzer.
  • the test result information of the test sample and the sample information of the sample to be tested are obtained from the sample information acquisition device.
  • the first conveying track in the conveying device is controlled to convey the sample to be tested to the smear preparation device.
  • the smear preparation device prepares the sample smear of the sample to be tested, and controls the second transport track of the transport device to transport the sample smear from the smear preparation device to the cell image analysis device; and analyzes from the preset according to the sample information of the sample to be tested
  • the mode set determines the operating mode of the cell image analysis device, and controls the cell image analysis device to perform image capture and analysis on the sample smear in the operating mode, thereby automatically determining the operating mode of the cell image analysis device, so that every time a cell image analysis device is acquired
  • the control device in the sample analysis system can automatically determine the operating mode of the cell image analysis device for the sample smear, so that the cell image analysis device can instruct the cell image analysis device to perform image capture and analysis based on the sample information, namely For different sample smears, the cell image analysis device is instructed to perform image shooting and analysis according to the operation mode of the sample smear matching, so as to improve the processing efficiency of the cell image analysis device and the
  • Figure 1 is an optional schematic diagram of an existing mode designation interface
  • FIG. 2 is a schematic diagram of an optional structure of a sample analysis system provided by an embodiment of the present invention.
  • FIG. 3 is an optional schematic diagram of detection result information provided by an embodiment of the present invention.
  • FIG. 4 is another optional schematic diagram of detection result information provided by an embodiment of the present invention.
  • FIGS. 5 and 6 are schematic diagrams of an optional structure of the cell image analysis device in the sample analysis system provided by the embodiment of the present invention.
  • FIG. 7 is a schematic diagram of an optional shooting mode of the whole cell analysis mode provided by an embodiment of the present invention.
  • FIGS 8 to 10 are schematic diagrams of an optional shooting mode of the blood WBC analysis mode provided by an embodiment of the present invention.
  • FIG. 11 is a schematic diagram of an optional shooting mode of the blood RBC analysis mode provided by an embodiment of the present invention.
  • FIG. 12 is a schematic diagram of an optional shooting mode of the blood PLT analysis mode provided by an embodiment of the present invention.
  • FIG. 13 to 15 are schematic diagrams of an optional shooting mode of the body fluid WBC analysis mode provided by the embodiment of the present invention.
  • 16 is a schematic diagram of another alternative structure of the sample analysis system provided by an embodiment of the present invention.
  • FIG. 17 is a schematic diagram of still another optional structure of the sample analysis system provided by an embodiment of the present invention.
  • FIG. 18 is a schematic diagram of an optional display mode of a mode designation interface provided by an embodiment of the present invention.
  • 19 is a schematic diagram of an optional structure of the control device in the sample analysis system provided by the embodiment of the present invention.
  • FIG. 20 is an optional flowchart of a sample analysis method provided by an embodiment of the present invention.
  • the terms "include”, “include” or any other variants thereof are intended to cover non-exclusive inclusion, so that the method or server including a series of elements not only includes the explicitly recorded Elements, but also include other elements that are not explicitly listed, or also include elements inherent to the implementation method or server.
  • the element defined by the sentence "includes a" does not exclude the existence of other related elements in the method or server that includes the element (such as steps in the method or units in the server).
  • the unit may be a part of a circuit, a part of a processor, a part of a program or software, etc.).
  • the sample analysis system provided by the embodiment of the present disclosure includes a series of devices, but the sample analysis system provided by the embodiment of the present disclosure is not limited to including the explicitly recorded devices.
  • the sample analysis method provided by the embodiment of the present disclosure includes a A series of steps, but the sample analysis method provided by the embodiment of the present disclosure is not limited to the recorded steps. It should be noted that in the following description, “embodiments” are referred to, which describe a subset of all possible embodiments, but it is understandable that “embodiments” can be the same subset or different subsets of all possible embodiments. And can be combined with each other without conflict.
  • a sample smear that is, a substrate for smearing the specimen, such as a glass sheet after evenly smearing a blood sample and staining the cells in it.
  • the sample analysis system 100 may include: a blood cell analyzer 101, a smear preparation device 102, and a cell
  • the blood cell analyzer 101 is used to perform detection on a sample to be tested to obtain detection result information.
  • the sample to be tested may be a blood sample, a body fluid sample, and other samples that need to be checked for various cell counts (such as blood routine).
  • a blood cell analyzer can perform blood routine testing on at least one of blood samples and body fluid samples. To detect at least one type of cells of WBC, RBC, and PLT in at least one of the blood sample and the body fluid sample.
  • the blood cell analyzer 101 outputs the detection result information of the sample to be tested after testing the sample to be tested.
  • the detection result information of the sample to be tested may be: the cell detection parameters and the target cells of each type of cell in the sample to be tested. At least one of the abnormal information detected by the cell detection parameters of each type of cell.
  • the blood cell analyzer 101 outputs the cells of each cell contained in the sample to be tested after detecting the sample to be tested. The value corresponding to the detection parameter.
  • the blood cell analyzer 101 also judges whether the value is abnormal based on the value corresponding to each cell detection parameter and the threshold value corresponding to each cell detection parameter.
  • the corresponding value will be marked as abnormal, as shown in the detection result information in Figure 4.
  • the blood cell analyzer can also perform abnormal judgment in other ways, such as directly judging based on the value corresponding to the cell detection parameter.
  • the cell detection parameter is defaulted (for example, the cell detection parameter is empty or the value corresponding to the cell detection parameter is the initial value), the value corresponding to the cell detection parameter directly displays abnormality, etc., this embodiment does not limit the way of judging abnormality.
  • the smear preparation device 102 is used to prepare a sample smear of the sample to be tested, so as to perform targeted analysis on specific cells in the sample to be tested, such as abnormal cells.
  • the smear preparation device 102 obtains the sample smear of the sample to be tested through operations such as pushing and staining.
  • operations such as pushing and staining.
  • one point that needs to be explained here is: currently, when preparing the sample smear of a body fluid sample, it is necessary to use a spin-off operation.
  • the smear preparation device 102 may include a first preparation device (eg, a first preparation device for smear preparation of a blood sample) for the characteristics of a sample smear of a body fluid sample.
  • a first preparation device eg, a first preparation device for smear preparation of a blood sample
  • a second preparation device such as a centrifugal spinner
  • the smear preparation device obtains a sample to be tested, if the sample to be tested is a blood sample, then Transport the sample to be tested to the first preparation device (such as a slide pusher), if the sample to be tested is a body fluid sample, then the sample to be tested is transported to the second preparation device (such as a centrifugal spinner), or a blood cell analyzer 101 can know the sample type of the sample to be tested.
  • the blood cell analyzer 101 determines that the sample to be tested is a blood sample, the sample to be tested is directly transported to the first preparation device; when the blood cell analyzer 101 determines that the sample to be tested is a body fluid sample , Directly transport the sample to be tested to the second preparation device.
  • a corresponding relationship is established between the sample smear prepared by the smear preparation device 102 and the detection result information obtained by the blood cell analyzer 101 to indicate that the sample smear and the detection result information belong to the same test subject
  • one way to establish the corresponding relationship between the two is to match the sample smear with the detected result information through the sample identification information (such as sample number) of the sample to be tested, for example, in the sample smear
  • a label area is set on the upper part, and the label area is used to set the sample identification information.
  • the smear preparation device 102 obtains the sample identification information from the blood cell analyzer 101 and sets the sample identification information in the label area.
  • the smear preparation device 102 has The function of generating a two-dimensional code, displaying the sample identification information in the form of a two-dimensional code, and printing the generated two-dimensional code on the label area.
  • the cell image analysis device 103 is used for image capture and analysis of the sample smear prepared by the smear preparation device 102, especially by taking the cell image of the sample smear to identify and locate the cells in the sample smear, and then Recognize and locate the cells for image capture and analysis.
  • An optional structure of the cell image analysis device 103 is shown in FIGS. 5 and 6.
  • the cell image analysis device 103 at least includes an imaging device 1031, a smear moving device 1032, and an image analysis device 1033.
  • the imaging device 1031 includes a camera 10312 and a lens group 10311, and is used to photograph the cells in the sample to be tested smeared on the sample smear.
  • the smear moving device 1032 is used to move the sample smear relative to the imaging device 1031 for imaging
  • the device 1031 captures a cell image of a specific area of the sample smear, and the image analysis device 1033 is used to analyze the cell image of the sample smear.
  • the lens group 10311 may include a first objective lens 3111 and a second objective lens 3112.
  • One of the first objective lens 3111 and the second objective lens 3112 is a low power objective lens, and the other is a high power objective lens.
  • the first objective lens 3111 is a low power objective lens
  • the second objective lens 3112 is a high power objective lens.
  • the first objective lens can be 10 times
  • the objective lens, the second objective lens 3112 may be a 100 times objective lens.
  • the lens group 10311 may further include a third objective lens 3113.
  • the third objective lens 3113 has a multiple between the multiples of the first objective lens and the second objective lens.
  • the third objective lens 3113 may be a 40-fold objective lens.
  • the cell image analysis device 103 further includes an identification device 1034, a smear clamping device 1035, and a smear recovery device 1036.
  • the identification device 1034 is used to identify the sample identification information of the sample smear
  • the smear clamping device 1035 is used to clamp the sample smear from the identification device 1034 to the smear moving device 1032, so as to drive the sample smear through the smear moving device 1032.
  • the slide moves relative to the imaging device 1031, and the image analysis device 1033 analyzes the cell image of the sample smear after the imaging device 1031 captures the cell image of the sample smear.
  • the smear recovery device 1036 is used to place the image analysis device 1033. Sample smears for analysis.
  • the cell image analysis device 103 also includes a smear basket loading device 1037 for loading a smear basket containing sample smears to be tested, and the smear clamping device 1035 is also used for loading the smear basket loaded on the smear basket loading device 1037.
  • the sample smears in the basket are clipped to the identification device 1034 for sample information identification.
  • the smear basket loading device 1037 is connected to the transport device 104 so that the sample smear prepared by the smear preparation device 102 can be transported to the cell image analysis device 103.
  • the transport device 104 includes a first transport track 1041 and a second transport track 1042.
  • the first transport track 1041 is used to transport the sample to be tested from the blood cell analyzer 101 to the smear preparation device 102
  • the second transport track 1042 is used to transport
  • the sample smear is transported from the smear preparation device 102 to the cell image analysis device 103 to complete the sample to be tested in the blood cell analyzer 101, the smear preparation device 102 and the cell image analysis through the first transport track 1041 and the second transport track 1042
  • the transmission between the devices 103 so that any sample to be tested can complete automatic detection, preparation of sample smears, image capture and analysis through the blood cell analyzer 101, the smear preparation device 102, and the cell image analysis device 103.
  • first transportation track 1041 and the second transportation track 1042 may be two parts of the same transportation track, or the first transportation track 1041 and the second transportation track 1042 may be two independent transportation tracks, but the two independent transportation tracks
  • a transfer rail is connected between the rails for transferring the sample smear from the first transfer rail 1041 to the second transfer rail 1042 after the smear preparation device 102 prepares the sample smear.
  • both tracks can be used for sample transmission. Therefore, the configuration of the first transport track 1041 and the second transport track 1042 is not limited and described in detail in this embodiment.
  • the sample information obtaining device 105 is used to obtain sample information of the sample to be tested.
  • the sample information of the sample to be tested is used to identify the sample to be tested, for example, it is used to identify at least one of the sample type of the sample to be tested and the subject to which the sample to be tested belongs, similar to that of the sample to be tested above.
  • Sample identification information which can be used to determine the sample type of the sample to be tested and the subject to which the sample to be tested belongs (that is, from which user's body the sample to be tested is collected from), and it can further identify the subject to which the sample to be tested belongs The department to which the person belongs (that is, the department to which the sample to be tested was sent for inspection).
  • one way for the sample information acquiring device 105 to acquire sample information of the sample to be tested is: the sample information acquiring device 105 and the aforementioned blood cell analyzer 101, smear preparation device 102, and cell image analysis device 103 At least one device is communicatively connected to obtain sample information of the sample to be tested from these devices or send the sample information of the sample to be tested to the sample information acquiring device 105 by these devices.
  • the sample analysis system can process multiple samples to be tested in sequence, and it may take a period of time for a sample to be tested from the blood cell analyzer 101 to the cell image analysis device 103, so that the sample information and cell images currently sent by the blood cell analyzer 101 The sample information currently sent by the analysis device is not for the same sample. Therefore, in this embodiment, the sample information acquisition device 105 can optionally acquire the sample information from the cell image analysis device 103.
  • the aforementioned blood cell analyzer 101, smear preparation device 102, and cell image analysis device 103 can also be communicatively connected with the control device 105 in this embodiment, and the sample information of the sample to be tested can also be transmitted to the control device 105, based on this
  • the sample information acquisition device 105 in this embodiment can be integrated into the control device 105.
  • the sample information acquiring device 105 scans the label area of the sample smear to acquire the sample information of the sample to be tested, such as
  • the sample information obtaining device 105 may include/connect a camera, and scan the two-dimensional code in the label area through the camera to obtain the sample type information of the sample to be tested and/or the subject to which the sample to be tested belongs.
  • the sample information obtaining device 105 scans the label area of the sample smear to obtain the sample label of the label area of the sample smear Information (such as the above two-dimensional code), the sample label is compared with the sample label information of each historical sample in the sample library to find the same sample label information, and the sample information of the historical sample with the same sample label information is used as the current Sample information of the sample to be tested.
  • the sample information obtaining device 105 scans the label area of the sample smear to obtain the sample label of the label area of the sample smear Information (such as the above two-dimensional code), the sample label is compared with the sample label information of each historical sample in the sample library to find the same sample label information, and the sample information of the historical sample with the same sample label information is used as the current Sample information of the sample to be tested.
  • the control device 106 is communicatively connected with the blood cell analyzer 101, the smear preparation device 102, the cell image analysis device 103, the transport device 104 and the sample information acquisition device 105 to control the actions of the above-mentioned various devices, especially the above-mentioned transport device 104 Acting with the cell image analysis device 103 and interacting with some of the above-mentioned devices, the processing procedure of the control device 106 is as follows:
  • test result information from the blood cell analyzer and the sample information of the sample to be tested from the sample information acquisition device; when the test result information meets a predetermined condition, control the first transport track to transport the sample to be tested to the smear preparation device for coating
  • the slide preparation device prepares the sample smear of the sample to be tested; controls the second transport track to transport the sample smear from the smear preparation device to the cell image analysis device; determines the cells from the preset analysis mode set according to the sample information of the sample to be tested
  • the operating mode of the image analysis device control the cell image analysis device to take and analyze the image of the sample smear in the operating mode.
  • the detection result information and the sample information of the sample to be tested may be actively acquired by the control device 106, or actively sent to the control device 106 by the blood cell analyzer 101 and the sample information acquisition device 105. Since the test result information and the sample information of the sample to be tested are used at different times, the control device 106 can obtain the test result information and the sample information of the sample to be tested in a time-sharing manner, for example, when the blood cell analyzer 101 obtains the test result information, When the sample smear is transported to the cell image analysis device 103, sample information of the sample to be tested is obtained. Of course, the control device 106 can also obtain the detection result information and the sample information of the sample to be tested at the same time, which is not limited in this embodiment.
  • control device 106 determines that the detection result information meets the predetermined conditions, it indicates that it is necessary to analyze the cells in the sample to be tested. At this time, the control device 106 controls the first transport track of the transport device 104 to transport the sample to be tested to the smear preparation device 102. After the smear preparation device 102 prepares the sample smear, the second conveying track of the conveying device 104 is controlled to convey the sample smear to the cell image analysis device 103.
  • the predetermined conditions may include but are not limited to at least one of the following:
  • the detection result information contains abnormal result information indicating that the sample to be tested is abnormal.
  • the abnormal result information may be directly detected by the blood cell analyzer 101 on the sample to be tested, or it may be obtained by a control device.
  • 106 is obtained according to the detection result information of the blood cell analyzer 101, and the abnormal result information may include but is not limited to at least one of the following information: abnormal values corresponding to the cell detection parameters of the sample to be tested, abnormal cells in the sample to be tested, The difference between the same cell parameter of each sample to be tested obtained from the same subject within the set interval exceeds the preset range.
  • the abnormal value corresponding to the cell detection parameter of the sample to be tested mainly indicates that a cell detection parameter is abnormal.
  • the value corresponding to the cell detection parameter does not meet the corresponding threshold (such as greater than the threshold or not within the threshold range), and the cell detection parameter is default ( For example, if the cell detection parameter is empty or the value corresponding to the cell detection parameter is the initial value), the value corresponding to the cell detection parameter directly indicates whether there is an abnormality (for example, it does not need to be determined by the threshold method), etc., are all regarded as the value corresponding to the cell detection parameter.
  • the presence of abnormal cells in the sample to be tested indicates that the sample to be tested is itself an abnormal sample, such as the presence of atypical lymphocytes in the sample to be tested, so the sample to be tested is directly judged as an abnormal sample.
  • the samples to be tested of the same type will not change significantly within a certain period of time. Therefore, if the samples to be tested obtained from the same subject within a set interval are The difference between the same cell parameter exceeds the preset range, indicating that the same cell parameter of the subject's sample to be tested has a large change within the set interval, and it will also be regarded as abnormal at this time.
  • the value of the cell parameter is within the normal range within the set interval, but the difference exceeds the preset range, it is also judged that the sample to be tested has abnormal abnormal result information, and the interval is set
  • the value of the time and the preset range can be determined according to the sample type information of the sample to be tested and the cell parameters in the sample to be tested, which will not be described in this embodiment.
  • the detection result information contains specific types of abnormal cell parameters.
  • the detection result information includes, but is not limited to, specific types of abnormal white blood cells.
  • the specific type of cell parameters are not limited in this embodiment.
  • the subject to which the test result information belongs is the preset object of interest.
  • the test result information is derived from but not limited to a sample to be tested from a patient with leukocyte disease, where the preset object of interest can be According to medical needs, this embodiment is not limited.
  • Another way of pre-determining conditions is: the test sample corresponding to the test result information comes from a specific department.
  • the test result information comes from but not limited to the reproductive medicine department. The specific department can be determined according to medical needs. This embodiment Not limited.
  • the control device 106 controls the sample to be tested from the blood cell analyzer 101 to the smear preparation device 102, if the control device 106 determines that the sample to be tested is a blood sample, it will pass through the first branch of the first transport track.
  • the test sample is transported to the first preparation device of the smear preparation device. If it is determined that the sample to be tested is a body fluid sample, the test sample is transported to the second preparation device of the smear preparation device through the second branch of the first transport track.
  • the timing for the control device 106 to determine the operating mode of the cell image analysis device may be: during the process of transporting the sample smear from the smear preparation device to the cell image analysis device on the second transport track, the sample smear is removed from the smear on the second transport track. Either time before the slide preparation device is transported to the cell image analysis device, after the sample smear is transported from the smear preparation device to the cell image analysis device on the second transport track, or after the control device 106 obtains the sample information of the sample to be tested .
  • the corresponding preset analysis mode set may include at least two analysis modes, and the control device 106 obtains the analysis mode matching the sample information of the sample to be tested from the at least two analysis modes as the operating mode of the cell image analysis device.
  • the at least two analysis modes included in the preset analysis mode set may be for different types of samples and/or different types of cells of the same type of samples.
  • the analysis modes in the preset analysis mode set may be implemented in the sample analysis system. Set up adjustments before or during the process to meet the testing needs of different samples.
  • the control device 106 includes a human-computer interaction device, such as a display screen, a camera, etc., and the human-computer interaction device responds to human-computer interaction instructions to set and adjust the preset analysis mode in advance through user intervention before the sample smear analysis
  • the analysis mode in the set, the preset analysis mode set adjusted in advance can automatically determine the operation mode of the cell image analysis device from the preset analysis mode set when the sample analysis system provided in this embodiment is used.
  • control device 106 determines the operating mode of the cell image analysis device, it controls the cell image analysis device to perform image capture and analysis on the sample smear in this operating mode. That is, this embodiment first determines that the cell image analysis device performs image capture and analysis. Run mode, and then instruct the shooting of the sample smear and the analysis of the captured cell image of the sample smear in the running mode.
  • the guidance for the shooting of sample smears includes but is not limited to at least one of the shooting area, the objective lens used in the shooting process, the sequence of the objective lens used in the shooting process, and the scanning and positioning method of the shooting area. For different types of samples to be tested, the process of taking sample smears will be different, which will be described in detail later in conjunction with the drawings.
  • the sample analysis system includes: a blood cell analyzer, a smear preparation device, a cell image analysis device, a transport device, a sample information acquisition device, and a control device.
  • the control device is configured to obtain a sample from the blood cell analyzer.
  • the test result information of the test sample and the sample information of the sample to be tested are obtained from the sample information acquisition device.
  • the first conveying track in the conveying device is controlled to convey the sample to be tested to the smear preparation device.
  • the smear preparation device prepares the sample smear of the sample to be tested, and controls the second transport track of the transport device to transport the sample smear from the smear preparation device to the cell image analysis device; and analyzes from the preset according to the sample information of the sample to be tested
  • the mode set determines the operating mode of the cell image analysis device, and controls the cell image analysis device to perform image capture and analysis on the sample smear in the operating mode, thereby automatically determining the operating mode of the cell image analysis device, so that every time a cell image analysis device is acquired
  • the control device in the sample analysis system can automatically determine the operating mode of the cell image analysis device for the sample smear, so that the cell image analysis device can instruct the cell image analysis device to perform image capture and analysis based on the sample information, namely According to different sample smears, the cell image analysis device is guided to perform image shooting and analysis according to the operation mode matched by the sample smear, so as to improve the processing efficiency of the cell image analysis device
  • the preset analysis mode set includes: the blood analysis mode for image capture and analysis of the cells in the blood sample smear, which is different from the blood analysis mode for image capture and analysis of the cells in the body fluid sample smear The body fluid analysis mode, and at least one of the whole cell analysis modes that are different from the blood analysis mode and the body fluid analysis mode in which all cells in the designated area of the sample smear are imaged and analyzed, corresponding to the control device 106 It is further configured to determine the operating mode of the cell image analysis device from the preset analysis mode set according to the sample information of the sample to be tested:
  • the operation mode of the cell image analysis device is determined from at least one of the blood analysis mode, the body fluid analysis mode, and the whole cell analysis mode. That is, the control device 106 determines the operation mode of the cell image analysis device from the blood analysis mode and the body fluid analysis mode. In the whole cell analysis mode, an analysis mode that matches the sample information of the sample to be tested is selected as the operating mode of the cell image analysis device.
  • the sample information may include sample type information and subject information.
  • the sample type information is used to indicate the type of the sample to be tested.
  • the sample to be tested is any one of a blood sample and a body fluid sample.
  • the information is used to point to the subject to which the sample to be tested belongs.
  • the corresponding control device 106 can determine the operating mode of the cell image analysis device according to the sample type information or subject information, and the determination process includes at least one of the following methods:
  • the sample type information in the sample information is a blood sample
  • set the blood analysis mode to the operating mode of the cell image analysis device, so that when the sample to be tested is a blood sample, the blood analysis mode can be set to cell image analysis The operating mode of the device.
  • the sample type information in the sample information is a body fluid sample
  • set the body fluid analysis mode to the operating mode of the cell image analysis device, so that when the sample to be tested is a body fluid sample, the body fluid analysis mode can be set to cell image analysis The operating mode of the device.
  • an analysis mode corresponding to the subject information is determined from the preset analysis mode set as the operating mode of the cell image analysis device.
  • the analysis mode corresponding to the subject information can be set in advance by user intervention before using the sample analysis system, and the analysis mode corresponding to the subject information is set through human-computer interaction, for example, the analysis mode corresponding to the subject information If it is a whole-cell analysis mode, it can be determined from the preset analysis modes that the whole-cell analysis mode is the operating mode of the cell image analysis device.
  • the subject information includes, but is not limited to, at least one of department information, age, gender, medication status, and treatment status, based on one or more of the subject information through human-computer interaction.
  • Set the corresponding analysis mode For example, the department information can indicate the department to which the sample to be tested belongs.
  • the corresponding analysis mode can be set for at least one department.
  • the analysis mode corresponding to the pediatric department is the whole cell analysis mode.
  • the corresponding analysis modes are blood WBC analysis mode, blood RBC analysis mode, and blood PLT analysis mode; for example, age can indicate that the subject is a child, adolescent, adult, and the elderly, and the test needs of subjects of different ages It may be different.
  • the corresponding analysis mode can be matched for subjects of different ages, so that the control device can determine the corresponding analysis mode as the operating mode of the cell image analysis device according to the age in the current subject information.
  • the corresponding analysis mode can also be set for other information in the subject. This implementation The examples will not be explained one by one.
  • the analysis mode corresponding to the preset target of interest is preset to be the whole-cell analysis mode, so that the subject pointed to by the subject information in the sample information is the preset focus
  • the control device sets the whole cell analysis mode to the operation mode of the cell image analysis device.
  • the whole cell analysis mode is set as the operating mode of the cell image analysis device to capture and analyze images of all cells in the area where the white blood cells in the sample to be tested are located.
  • the preset attention object may also be other patients, which is not described in this embodiment one by one.
  • the analysis mode corresponding to the preset object of interest is set in advance by the user, which is not described in this embodiment one by one.
  • the department information in the subject information indicates that the sample to be tested comes from a preset department, then it is determined from the preset analysis mode set that the analysis mode corresponding to the preset department is the operating mode of the cell image analysis device. If the analysis mode corresponding to the preset department is preset to the whole cell analysis mode, and the department information in the subject information indicates that the sample to be tested comes from the preset department, set the whole cell analysis mode to the operating mode of the cell image analysis device If the department in the subject information indicates that the sample to be tested is from the neonatology department, set the whole cell analysis mode to the operating mode of the cell image analysis device. It should be noted that the preset departments and corresponding analysis modes are set by the user according to the reagent requirements, which are not described in this embodiment one by one.
  • the preset object of interest, the preset department, the analysis mode corresponding to the preset object of interest, and the analysis mode corresponding to the preset department can be set by the user in advance before using the sample analysis system to allow the user to intervene before using the sample analysis system. Preset the matching analysis mode for the target of interest and the preset department, so that after the subject information is obtained, the corresponding analysis mode can be automatically selected according to the subject information, and the sample to be tested for the subject information can be targeted. Processing to improve processing accuracy.
  • the process of taking a sample smear by the cell image analysis device is as follows:
  • the shooting area can be a fixed area, and the position of the fixed area can be preset or determined according to the image taken by the low-power objective lens (such as the above-mentioned first objective lens) in the cell image analysis device Shooting area; the shooting area can also be an indeterminate area.
  • the shooting area can be determined by human-computer interaction, such as the user designating the shooting location and shooting size (the shooting location and shooting size define the shooting area), or the user specifies the shooting Location, a shooting area is automatically determined according to the shooting location, for example, a circular area or a rectangular area is determined with the shooting location as the center.
  • the human-computer interaction method may include, but is not limited to, human-computer interaction through a display interface, human-computer interaction instructions sent through voice, and so on.
  • the first objective lens in the cell image analysis device and the high-power objective lens (such as a 100-time objective lens) in the second objective lens are used to scan the entire shooting area to obtain an image of the shooting area under the high-power objective lens.
  • the full-area scan means that every position of the shooting area must be scanned, and when the high-power objective lens scans the whole area of the shooting area, because the high-power objective lens has a large magnification, the high-power objective lens needs to be scanned multiple times to complete the full-area scan. Therefore, the high magnification objective lens will get the image of the scan area every time it is scanned. After the last scan, the images obtained each time will be stitched into the imaging area of the shooting area under the high magnification objective lens in the order of scanning.
  • Figure 7 shows the shooting in the whole-cell analysis mode.
  • First determine the shooting area, and then scan the entire shooting area under a 100x objective lens. During the full-area scanning process, multiple images will be obtained, and the entire area will be scanned. After the end, the multiple images are stitched into the image shown in Figure 7 according to the scanning sequence.
  • one or more shooting areas can be determined in the whole-cell analysis mode, and each shooting area is scanned across the whole area to obtain the stitched image of each shooting area. If you need to stitch all the shooting areas into one image, It is also possible to further stitch together to obtain an image corresponding to all the shooting areas after the images of each shooting area are stitched together.
  • control device 106 can select a matching analysis mode from the blood analysis mode, body fluid analysis mode, and whole cell analysis mode in the preset analysis mode set according to the sample type information and subject information.
  • the operating mode of the cell image analysis device it realizes the automatic determination of the operating mode and improves the accuracy.
  • the detection result information of the sample to be tested will also trigger the cell image analysis device to adopt different operating modes.
  • the detection result information of the sample to be tested indicates abnormal white blood cells in the blood sample and indicates abnormal red blood cells in the blood sample
  • the control device 106 of this embodiment is further configured to: determine from the preset analysis mode set according to the sample information of the sample to be tested and the detection result information
  • the operation mode of the cell image analysis device makes the operation mode of the cell image analysis device match the sample information and the detection result information of the sample to be tested.
  • the analysis mode that matches the white blood cells in the blood sample needs to be selected from the preset analysis mode set as the operating mode; if the detection result information indicates a body fluid sample If the platelet is abnormal, it is necessary to select the analysis mode that matches the platelets in the body fluid sample from the preset analysis mode set as the operating mode. Therefore, the blood analysis mode and the body fluid analysis mode of this embodiment further include the analysis corresponding to the cell type. Modes, the following are respectively described from the blood analysis mode and the body fluid analysis mode:
  • the blood analysis mode further includes: a blood WBC analysis mode for image capture and analysis of white blood cells in a blood sample smear, a blood RBC analysis mode for image capture and analysis of red blood cells in a blood sample smear, At least one of the blood PLT analysis modes for image capture and analysis of platelets in a blood sample smear, that is, the blood analysis mode includes: the analysis mode corresponding to at least one type of white blood cell, red blood cell, and platelet.
  • the corresponding cell analysis mode can also be added to the blood analysis mode to meet the development needs of medical technology.
  • the control device 106 is further configured to adopt at least one of the following methods when determining the operation mode of the cell image analysis device from the preset analysis mode set according to the sample information and the detection result information of the sample to be tested:
  • the blood WBC analysis mode is set to the operating mode of the cell image analysis device, and the detection result The information contains abnormal results indicating that the white blood cells in the sample to be tested are abnormal, indicating that the white blood cells in the sample to be tested are abnormal, and the sample to be tested is a blood sample.
  • the control device 106 can set the blood WBC analysis mode to the cell image analysis device. Operating mode.
  • the sample type information in the sample information is a blood sample
  • the detection result information contains abnormal result information indicating that the red blood cells in the sample to be tested are abnormal
  • set the blood RBC analysis mode to the operating mode of the cell image analysis device, and the same detection
  • the result information contains abnormal results indicating that the red blood cells in the sample to be tested are abnormal.
  • the result information indicates that the red blood cells in the sample to be tested are abnormal, and the sample to be tested is a blood sample.
  • the control device 106 can set the blood RBC analysis mode to the cell image analysis device. Mode of operation.
  • the control device 106 can set the blood PLT analysis mode to the cell image analysis device. Mode of operation.
  • the sample type information in the sample information is a blood sample
  • the test result information indicates that there are primitive cells in the sample to be tested
  • set the whole cell analysis mode to the operating mode of the cell image analysis device, where the test result information indicates the sample to be tested
  • the presence of blast cells in the test means that the sample to be tested is an abnormal sample. Taking patients with leukemia as an example, there are abnormal white blood cells in the test samples of patients with leukemia—primordial cells.
  • To measure the sample set the whole cell analysis mode to the operating mode of the cell image analysis device. Please refer to the above description for the shooting process of the whole cell analysis mode, which will not be described in detail here.
  • the control device 106 can further combine the detection result information of the blood sample to subdivide the analysis mode corresponding to the sample smear of the blood sample, so as to determine the operation mode of the cell image analysis device as the detection result information of the blood sample.
  • the matched analysis mode realizes the further refinement and automatic determination of the operation mode, so that the cell image analysis device can be guided to perform image shooting and analysis for different abnormalities in blood samples.
  • the unified method is adopted. In terms of operating mode, the processing efficiency of the cell image analysis device and the accuracy of the analysis results are further improved.
  • the detection result information of a blood sample contains abnormal result information indicating that the white blood cells in the sample to be tested are abnormal, which means that the white blood cells in the sample to be tested are abnormal.
  • the blood WBC analysis mode matching the white blood cells of the blood sample is set to cell image analysis The operating mode of the device. The shooting process of the cell image analysis device in blood WBC analysis mode, blood RBC analysis mode, and blood PLT analysis mode will be described below in conjunction with the accompanying drawings:
  • the cell image analysis device searches and determines the shooting area through a low-power objective lens (such as a 10x objective lens) in the first objective lens and the second objective lens.
  • a low-power objective lens such as a 10x objective lens
  • the low-power objective lens can move from the head to the tail of the sample smear to search.
  • the determined shooting area may be, but is not limited to, the single-layer cell area at the junction of the tail and the body of the sample smear (also called the body-tail junction), and the determined shooting area may be One or more regions;
  • the low-power objective lens of the cell image analysis device scans and locates the white blood cells in the shooting area.
  • the low-power objective lens can be scanned and positioned in a battlement mode. For example, the low-power objective lens moves from the first direction to the second direction to scan and then Move and scan from the second direction to the first direction, and perform multiple times to scan and locate each position of the shooting area, where the first direction to the second direction and the second direction to the first direction can be the head of the sample smear To the vertical direction of the tail; the white blood cells positioned in the scan are photographed through the high-power objective lens (such as a 100-fold objective lens) in the first objective lens and the second objective lens of the cell image analysis device.
  • the high-power objective lens such as a 100-fold objective lens
  • the 10x objective lens in the cell image analysis device is used to automatically search from the head to the tail to determine the shooting area of the sample smear.
  • the arrow in Figure 8 shows the direction from the head to the tail.
  • Tail search then use a 10x objective to scan and locate the white blood cells in the shooting area in a battlement pattern as shown in Figure 9; after scanning to locate the white blood cells, use a 100x objective to shoot the white blood cells located in the scan, as shown in Figure 10.
  • the clarity of the visual field image under the 100x objective lens is improved.
  • the leukocytes located in the scan are magnified by the 100x objective lens, and then taken by the camera in the cell image analysis device to obtain the magnified leukocyte image shown in Figure 10.
  • the cell image analysis device searches and determines the shooting area through a low-power objective lens (such as a 10x objective lens) in the first objective lens and the second objective lens.
  • a low-power objective lens such as a 10x objective lens
  • the low-power objective lens can move from the head to the tail of the sample smear to search.
  • the determined shooting area can be, but not limited to, the single-layer cell area at the junction of the tail and the body of the sample smear (referred to as the body tail junction), and the determined shooting area can be one or More than one area;
  • the red blood cells in the photographing area are photographed by a high-power objective lens (such as a 100-time objective lens) in the first objective lens and the second objective lens of the cell image analysis device.
  • a high-power objective lens such as a 100-time objective lens
  • the shooting area is determined under the 10x objective lens (as shown in the box in 11), and then the shooting area is taken under the 100x objective lens, or the shooting area is set in the shooting area and then The area covered by the shooting area is photographed under a 100x objective lens.
  • the shooting area is determined under the 10x objective lens (as shown in the box in 11), and then the shooting area is taken under the 100x objective lens, or the shooting area is set in the shooting area and then The area covered by the shooting area is photographed under a 100x objective lens.
  • multiple images may be captured, and there may be overlaps between adjacent images. All the images under the 100x objective lens are stitched together to obtain an image of the shooting area shown in FIG. 11.
  • the cell image analysis device searches and determines the shooting area through a low-power objective lens (such as a 10x objective lens) in the first objective lens and the second objective lens.
  • a low-power objective lens such as a 10x objective lens
  • the low-power objective lens can move from the head to the tail of the sample smear to search.
  • the determined shooting area may be, but not limited to, a single-layer cell area at the body-tail junction of the sample smear, and the determined shooting area may be one or more areas;
  • the platelets in the photographing area are photographed by a high-power objective lens (such as a 100-time objective lens) in the first objective lens and the second objective lens of the cell image analysis device.
  • a high-power objective lens such as a 100-time objective lens
  • the shooting area is determined under the 10x objective lens (as shown in the box in 12), and then the shooting area shown in Figure 12 is taken under the 100x objective lens, or set in the shooting area
  • the photographing area is then photographed under the 100x objective lens of the area covered by the photographing area.
  • multiple images may be taken, and there may be overlaps between adjacent images. All the images under the 100x objective lens are stitched together to obtain an image of the shooting area shown in FIG. 12.
  • the cell image analysis device can refer to the above-mentioned blood WBC analysis mode, blood RBC analysis mode, and blood PLT analysis mode to take pictures of the sample smears, so that the cell image analysis device can adopt the operation mode matching the operation mode after determining the operation mode.
  • Image capture mode for image capture.
  • the shooting methods of blood RBC analysis mode and blood PLT analysis mode are the same, so blood RBC analysis mode and blood PLT analysis mode are the same analysis mode, namely blood RBC analysis
  • the shooting mode of the cell image analysis device in the blood PLT analysis mode is the same as that in the blood PLT analysis mode. Under actual sample detection requirements, the shooting mode of the cell image analysis device in the blood RBC analysis mode and the blood PLT analysis mode may be different. The shooting method will be explained.
  • the body fluid analysis mode further includes: body fluid WBC analysis mode for image capture and analysis of white blood cells in the body fluid sample smear and image capture and analysis of red blood cells in the body fluid sample smear
  • body fluid WBC analysis mode for image capture and analysis of white blood cells in the body fluid sample smear
  • red blood cells in the body fluid sample smear
  • the body fluid analysis mode includes: the analysis mode corresponding to at least one type of white blood cell and red blood cell, if with the development of medical technology, other body fluid samples are found to have an impact on the human body
  • the analysis mode corresponding to the cells can also be added to the body fluid analysis mode to meet the development needs of medical technology.
  • the control device 106 is further configured to adopt at least one of the following methods when determining the operation mode of the cell image analysis device from the preset analysis mode set according to the sample information and the detection result information of the sample to be tested:
  • the body fluid WBC analysis mode is set to the operating mode of the cell image analysis device, where the detection result
  • the information contains abnormal results indicating that the white blood cells in the sample to be tested is abnormal, indicating that the white blood cells in the sample to be tested are abnormal, and the sample to be tested is a body fluid sample.
  • the control device 106 can set the body fluid WBC analysis mode to the cell image analysis device. Operating mode.
  • the control device 106 can set the body fluid RBC analysis mode to the cell image analysis device. Mode of operation.
  • the control device 106 can further combine the detection result information of the body fluid sample to subdivide the analysis mode corresponding to the sample smear of the body fluid sample, so as to determine the operating mode of the cell image analysis device as the detection result information of the body fluid sample
  • the matched analysis mode realizes further refinement and automatic determination of the operation mode.
  • the detection result information of a body fluid sample contains abnormal result information indicating that the white blood cells in the sample to be tested are abnormal, which means that the white blood cells in the sample to be tested are abnormal.
  • the body fluid WBC analysis mode that matches the white blood cells of the body fluid sample is set to cell image analysis The operating mode of the device. The following describes the shooting process of the cell image analysis device in the body fluid WBC analysis mode and the body fluid RBC analysis mode:
  • the shooting area of the sample smear of the body fluid sample needs to be based on the specific shape area in the sample smear, such as specifying the shooting area in the specific shape area in the sample smear, the shooting position and shooting size of the shooting area can be through human-computer interaction
  • the method is determined, for example, through the display interface for human-computer interaction, the user specifies the shooting position in the area of a specific shape in the sample smear, and the shooting size is specified based on the extension of the shooting position, so as to obtain the shooting area, or the above shooting area can be covered
  • Areas with specific shapes in the sample smear for example, the shooting area includes the area with a specific shape in the sample smear or a
  • the low-power objective such as a 10x objective
  • the low-power objective lens can be scanned and positioned in a battlement type manner.
  • the low-power objective lens moves from the first direction to the second direction to scan and then moves from the second direction to the first direction to scan, repeating multiple times to scan and locate each position of the shooting area, where the first direction is toward the second direction and
  • the second direction to the first direction can be the vertical direction from the head to the tail of the sample smear;
  • the white blood cells are positioned by the high-power objective (such as a 100-time objective) in the first objective lens and the second objective lens of the cell image analysis device Take a shot.
  • the cell image analysis device acquires the user's designated shooting area on the sample smear shown in Figure 13, which is located in a specific shape of the sample smear (circular area as shown in Figure 13).
  • the leukocytes in the shooting area are scanned and located in the battlement pattern shown in Figure 14 through the 10x objective lens of the cell image analysis device, and then the leukocytes located in the scan are magnified by the 100x objective lens.
  • the camera in the cell image analysis device The photograph was taken to obtain the enlarged image of white blood cells shown in FIG. 15.
  • the cell image analysis device can refer to the above-mentioned body fluid WBC analysis mode and body fluid RBC analysis mode to capture the sample smear image, so that the cell image analysis device can use the image capture method matching the operating mode to perform the image after determining the operating mode Shooting.
  • the abnormal result information of the detection result information includes at least one of the following information: abnormal values corresponding to the cell detection parameters of the sample to be tested, abnormal cells in the sample to be tested, and The difference between the same cell parameter of each sample to be tested obtained from the same subject within the set interval exceeds the preset range.
  • the abnormal value corresponding to the cell detection parameter of the sample to be tested mainly indicates that a cell detection parameter is abnormal.
  • the value corresponding to the cell detection parameter does not meet the corresponding threshold (such as greater than the threshold or not within the threshold range), and the cell detection parameter is default ( For example, if the cell detection parameter is empty or the value corresponding to the cell detection parameter is the initial value), the value corresponding to the cell detection parameter directly indicates whether there is an abnormality (for example, it does not need to be determined by the threshold method), etc., are all regarded as the value corresponding to the cell detection parameter. abnormal.
  • the information corresponding to the white blood cells in the detection result information corresponding to the blood sample is shown in Table 1.
  • Table 1 Information corresponding to white blood cells in the test result information corresponding to the blood sample
  • abnormal Remarks Abnormal white blood cell scatter plot To Abnormal scatter plot of nucleated red blood cells To Anti-lysed red blood cells? To Primordial cells? To Abnormal lymphocytes/primordial cells? To Immature granulocytes? To Nucleated red blood cells? To Nuclear shift left? To Lipid particles? To Infect red blood cells?
  • Leukopenia Determine whether the value corresponding to the parameter meets the threshold
  • the above table 1 shows the abnormal result information for the presence of white blood cells. From the above table 1, it can be seen that the parameters “white blood cell scatter diagram abnormal” to "infected red blood cells?" From “presence of nucleated red blood cells” to “leukopenia”, whether the value corresponding to the cell detection parameter meets the corresponding threshold is used to determine whether there is abnormality. Of course, for the white blood cells shown in Table 1 above, if one of the output items is empty or is a default value, the cell detection parameters are considered to be default, and the default cell detection parameters are considered to be abnormal at this time.
  • the information corresponding to the red blood cells in the detection result information corresponding to the blood sample is shown in Table 2.
  • the above table 2 shows the abnormal result information for the presence of red blood cells. From the above table 1, it can be seen that "abnormal reticulocyte scatter diagram" to "abnormal red blood cell histogram” and "iron deficiency?" are all corresponding to the cell detection parameters. The value directly indicates whether there is an abnormality, and the remaining is to determine whether there is an abnormality by whether the value corresponding to the cell detection parameter meets the corresponding threshold. Of course, for the red blood cells shown in Table 2 above, if one of the output is empty or the default value, the cell detection parameters are considered to be default. At this time, the default cell detection parameters are considered to be abnormal, for example, if there is no output of reticulocytes If the scatter chart is abnormal, it is directly considered that the abnormality exists.
  • the information corresponding to the platelets in the detection result information corresponding to the blood sample is shown in Table 3, which shows abnormalities in the platelets.
  • the above table 3 shows the abnormal results information for the presence of platelets. From the above table 3, it can be seen that “platelet aggregation" to “platelet histogram abnormality" are directly indicated by the value corresponding to the cell detection parameter whether there is abnormality, and the rest is through the cell Check whether the value corresponding to the parameter meets the corresponding threshold to determine whether there is an abnormality.
  • the cell detection parameters are considered to be default, and the default cell detection parameters are considered to be abnormal. For example, if there is no platelet aggregation, then It is directly believed that the abnormality exists.
  • abnormal cells in the above-mentioned sample to be tested indicates that the sample to be tested is itself an abnormal sample, and there are primitive cells in the abnormal sample.
  • this type of sample to be tested is directly judged to be abnormal.
  • the samples to be tested of the same type will not change significantly within a certain period of time. Therefore, if the samples to be tested obtained from the same subject within a set interval are The difference between the same cell parameter exceeds the preset range, indicating that the same cell parameter of the subject's sample to be tested has a large change within the set interval, and it will also be regarded as abnormal at this time.
  • the sample to be tested has abnormal abnormal result information, for example, for red blood cells. Said that the red blood cell values tested by the same subject in three days were 3.5*10 12 /L and 5.9*10 12 /L, although they were all in the normal range, the difference was too large. Therefore, the parameters of normal physiological processes are not within three days. If such a big change occurs, it is considered abnormal at this time.
  • the value change of red blood cells within three days is taken as an example.
  • the interval time and the preset range can be set according to the sample type information of the sample to be tested. It is determined with the cell parameters in the sample to be tested. This embodiment will not describe them one by one and limit the value of the set interval time and the preset range.
  • the control device 106 When the detection result information obtained by the control device 106 indicates at least one of the above-mentioned abnormalities, the control device 106 will determine the operation mode of the cell image analysis device from the preset analysis mode set according to the sample information and the detection result information of the sample to be tested.
  • the control device 106 can directly obtain the abnormal result from the blood cell analyzer, that is, the blood cell analyzer determines whether there is an abnormality, and carries the abnormal result in the detection result information, or the control device 106 To determine whether there is an abnormality.
  • control device 106 can issue a prompt message, which is used to instruct the user to select Either input the operating mode of the cell image analysis device, or the prompt message sent by the control device 106 includes the analysis mode to be selected, and the analysis mode to be selected is different from any analysis mode in the preset analysis mode set, and the analysis mode to be selected may be It is provided to the user, such as outputting the candidate analysis mode through the control device 106 for the user to select the operation mode.
  • the manner in which the control device 106 outputs the analysis mode to be selected includes, but is not limited to: at least one output manner of display output, output through voice, and output through text.
  • the cell image analysis device can perform image shooting and positioning of the sample smear in the operating mode, wherein the operating mode of the cell image analysis device includes one or more than one. If the operating mode of the cell image analysis device is one, then after the image capture and analysis is completed in this operating mode, it waits for image capture and analysis of the next sample smear; if the operating mode of the cell image analysis device includes more than one, Such as two or three, etc., the cell image analysis device can sequentially take and analyze the same sample smear in multiple operating modes.
  • the operating modes of the cell image analysis device include blood WBC analysis mode and blood RBC
  • the cell image analysis device uses the above-mentioned blood WBC analysis mode and blood RBC analysis mode to capture images of the same sample smear, and analyzes each cell image after the shooting is completed, or uses the above-mentioned blood
  • the shooting process of WBC analysis mode and blood RBC analysis mode During the sequential shooting of the same sample smear, each image can be analyzed immediately. During the analysis process, the sample can be continued in the remaining operating modes. Smears are taken for image shooting, so that analysis and image shooting can be carried out at the same time.
  • the operation mode of the cell image analysis device may be determined at the same time or determined by time-sharing sequentially. Simultaneous determination means that more than one operating mode can be determined at the same time based on the test result information. For example, in a blood sample, the test result output by the blood cell analyzer indicates that there are abnormal white blood cells and red blood cells in the blood sample, and the control device simultaneously The blood WBC analysis mode and the blood RBC analysis mode are determined as operating modes.
  • an optional way for the control device 106 to determine the multiple operating modes of the cell image analysis device in a time-sharing sequence is as follows:
  • the control device 106 is further configured to: if the cell image analysis device recognizes that there are other abnormalities in the sample smear in the operating mode, select the analysis mode corresponding to the other abnormalities from the preset analysis mode set as the additional operating mode, and set The cell image analysis device performs image capture and analysis on the sample smear in the additional operation mode, so as to automatically add the operation mode of the cell image analysis device in the process of analyzing the sample to be tested, that is, the sample analysis process in the operation mode It can detect abnormalities in sample smears in real time and add corresponding operating modes to further instruct the cell image analysis device to adopt operating modes that match the abnormalities for image capture and analysis, and further improve the accuracy of the processing results.
  • abnormalities are different from the corresponding abnormalities in the operating mode.
  • the corresponding abnormalities in the operating mode are white blood cell abnormalities, and other abnormalities may be the abnormalities other than white blood cell abnormalities in the sample smear identified in the operating mode, such as red blood cells. Abnormalities and/or platelet abnormalities, etc.
  • the method for identifying other abnormalities in the sample to be tested in the operating mode can refer to the analysis method of the current cell image analysis device, which will not be described in this embodiment.
  • the other abnormalities recognized by the cell image analysis device are for the abnormalities of the same sample type.
  • the cell image analysis device recognizes the presence of red blood cell abnormalities in the sample to be tested in the blood WBC analysis mode, and then starts from the preset Select the blood RBC analysis mode in the analysis mode set as the additional operation mode.
  • the control process of the control device 106 to the cell image analysis device includes: the control device 106 is also used to: make the cell image analysis device call after the image capture and analysis of the sample smear in the operation mode
  • the additional operation mode performs image capture and analysis of the sample smear, even if the cell image analysis device sequentially calls the operation mode and the additional operation mode to perform image capture and analysis of the sample smear.
  • the control device 106 will further select the analysis mode corresponding to the other abnormalities from the preset analysis mode set as another additional operation mode, so that After the cell image analysis device completes the image capture and analysis of the sample smear in the additional operation mode, another additional operation mode is called to perform image capture and analysis on the sample smear prepared by the smear preparation device.
  • the control device 106 may issue a prompt message, which is used to instruct the user to select or input the operating mode of the cell image analysis device, Or the prompt information sent by the control device 106 includes the analysis mode to be selected, and the analysis mode to be selected is different from any analysis mode in the preset analysis mode set.
  • the analysis mode to be selected can be provided to the user, such as output by the control device 106
  • the to-be-selected analysis mode is for the user to select the operating mode.
  • the manner in which the control device 106 outputs the analysis mode to be selected includes, but is not limited to: at least one output manner of display output, output through voice, and output through text.
  • the control device 106 can add an operation mode to the cell image analysis device when the cell image analysis device analyzes and recognizes other abnormalities, and causes the cell image analysis device to sequentially call the operation mode and the additional operation mode to the sample.
  • Smear is used for image shooting and analysis to realize the automatic determination and call of additional operating modes, so that the control device can add corresponding operating modes in real time according to the abnormalities in the sample smear during the analysis process of the cell image analysis device, and further guide the cell image
  • the analysis device adopts an operation mode matched with the abnormality for image shooting and analysis, which further improves the accuracy of the processing result.
  • FIG. 16 shows another optional structure of the sample analysis system provided by the embodiment of the present invention.
  • the sample analysis system 200 shown in FIG. 16 may include: a blood cell analyzer 201, a smear preparation device 202, and a cell image analysis system.
  • the device 203, the transport device 204, and the control device 205 may include: a blood cell analyzer 201, a smear preparation device 202, and a cell image analysis system.
  • the device 203, the transport device 204, and the control device 205 may include: a blood cell analyzer 201, a smear preparation device 202, and a cell image analysis system.
  • the device 203, the transport device 204, and the control device 205 may include: a cell image analysis system.
  • the blood analysis 201 is used for testing the sample to be tested to obtain the test result information.
  • the smear preparation device 202 is used to prepare a sample smear of the sample to be tested.
  • the cell image analysis device 203 is used for image capture and analysis of the sample smear prepared by the smear preparation device.
  • the transport device 204 includes a first transport track 2041 and a second transport track 2042.
  • the first transport track is used to transport the sample to be tested from the blood cell analyzer to the smear preparation device
  • the second transport track is used to transport the sample smear from The smear preparation device is transported to the cell image analysis device.
  • the control device 205 is in communication connection with the blood cell analyzer 201, the smear preparation device 202, the cell image analysis device 203 and the transport device 204, and is configured to:
  • test result information of the sample to be tested from the blood cell analyzer, and when the test result information meets the predetermined conditions, control the first transport track to transport the sample to be tested to the smear preparation device, so that the smear preparation device prepares the sample of the sample to be tested Smear; control the second transport track to transport the sample smear from the smear preparation device to the cell image analysis device; determine the cell image analysis device from the preset analysis mode set according to the sample information and/or detection result information of the sample to be tested The operating mode; controlling the cell image analysis device to take and analyze the image of the sample smear in the operating mode.
  • the sample analysis system 200 shown in FIG. 16 is aimed at blood samples, and the control device 205 performs detection based on the sample information of the sample to be tested and the sample to be tested. At least one of the result information determines the operating mode of the cell image analysis device 203. Since the sample analysis system 200 shown in FIG. 16 is for blood samples, the control device determines the operation mode of the cell image analysis device 203 according to the sample information of the sample to be tested. In the operating mode, there is no need to determine based on the sample type information in the sample information, and the smear preparation device 202 may only include the first preparation device for smear preparation of the blood sample. The control device 205 can obtain sample information from at least one of the blood cell analyzer 201, the smear preparation device 202, and the cell image analysis device 203. For details, please refer to the relevant description in the previous system embodiment.
  • the description of the blood cell analyzer 201, the cell image analysis device 203, and the transport device 204 can refer to the relevant description in the sample analysis system 100 shown in FIG. 1, and will not be described in detail here.
  • the difference between the control device 205 in the sample analysis system 200 shown in FIG. 16 and the above-mentioned control device 106 is that the control device 205 according to at least one of the sample information of the sample to be tested and the detection result information of the sample to be tested, Determine the operating mode of the cell image analysis device from the preset analysis mode set, that is, the operating mode of the cell image analysis device determined by the control device 205 corresponds to at least one of the sample information of the sample to be tested and the detection result information of the sample to be tested .
  • the control device 205 determines the timing of the operation mode, and the control device 205 controls the cell image analysis device in this
  • the control device 205 controls the cell image analysis device in this
  • the sample analysis system includes: a blood cell analyzer, a smear preparation device, a cell image analysis device, a transport device, and a control device.
  • the control device is configured to obtain the test result of the sample to be tested from the blood cell analyzer Information, when the detection result information meets the predetermined conditions, the first transport track in the transport device is controlled to transport the sample to be tested to the smear preparation device, so that the smear preparation device prepares the sample smear of the sample to be tested, and controls the second transport device 2.
  • the transport track transports the sample smear from the smear preparation device to the cell image analysis device; and according to the sample information and/or detection result information of the sample to be tested, the operating mode of the cell image analysis device is determined from the preset analysis mode set, Control the cell image analysis device to perform image capture and analysis on the sample smear in the operating mode, thereby automatically determining the operating mode of the cell image analysis device, so that each sample to be tested can be obtained through the sample analysis system
  • the control device automatically determines the operating mode of the cell image analysis device for the sample smear, so that the cell image analysis device can instruct the cell image analysis device to perform image shooting and analysis according to the sample information, that is, match different sample smears according to the sample smear
  • the operating mode of the cell image analysis device guides the image capture and analysis of the cell image analysis device, improves the processing efficiency of the cell image analysis device and the accuracy of the processing results, and overcomes the current manual specified operating mode for the same image capture and analysis of sample smears
  • the preset analysis mode set includes: the blood WBC analysis mode for image capture and analysis of white blood cells in blood sample smears, and the image capture and analysis of red blood cells in blood sample smears At least one of the blood RBC analysis mode, the blood PLT analysis mode for image capture and analysis of platelets in the blood sample smear, and the whole cell analysis mode for image capture and analysis of all cells in the designated area of the blood sample smear
  • the corresponding control device 205 is further configured to determine the operation mode of the cell image analysis device from the preset analysis mode set according to the detection result information of the sample to be tested:
  • the operation mode of the cell image analysis device is determined from at least one of the blood WBC analysis mode, the blood RBC analysis mode, the blood PLT analysis mode, and the whole cell analysis mode to determine the operation mode of the cell image analysis device from these analyses.
  • the analysis mode matching the detection result information is selected from the modes as the operating mode of the cell image analysis device.
  • the detection result information of the sample to be tested is related to the white blood cells in the blood sample (such as abnormal white blood cells)
  • the control device uses the blood WBC analysis mode as the operating mode of the cell image analysis device
  • the cell image analysis device can be based on the above blood WBC analysis mode
  • the shooting method is to take images of sample smears.
  • the analysis mode can be the same analysis mode, that is, the blood RBC analysis mode and the blood PLT analysis mode have the same shooting mode. In the actual sample detection process, the blood RBC analysis mode and the blood PLT analysis mode have different shooting modes.
  • control device 205 determines the operation mode of the cell image analysis device from the blood WBC analysis mode, the blood RBC analysis mode, the blood PLT analysis mode, and the whole cell analysis mode is as follows:
  • the control device 205 is further configured to adopt at least one of the following methods when determining the operation mode of the cell image analysis device from the preset analysis mode set according to the detection result information of the sample to be tested:
  • the blood WBC analysis mode is set to the operating mode of the cell image analysis device.
  • the blood RBC analysis mode is set as the operation mode of the cell image analysis device.
  • the blood PLT analysis mode is set to the operating mode of the cell image analysis device.
  • the whole cell analysis mode is set to the operating mode of the cell image analysis device.
  • the abnormal result information of the detection result information includes at least one of the following information: abnormal values corresponding to the cell detection parameters of the sample to be tested, abnormal cells in the sample to be tested, The difference between the same cell parameter of each sample to be tested exceeds the preset range.
  • the control device 205 determines the description of the operation mode of the cell image analysis device from the blood WBC analysis mode, blood RBC analysis mode, blood PLT analysis mode, and whole cell analysis mode, and the blood WBC analysis mode Please refer to the previous embodiment for the shooting modes in the blood RBC analysis mode, blood PLT analysis mode, and whole cell analysis mode, which will not be described in this embodiment.
  • the sample information on which the control device 205 determines the operating mode of the cell image analysis device includes subject information, and the corresponding control device 205 is further configured to obtain information from the pre-test based on the detection result information of the sample to be tested. It is assumed that at least one of the following methods is used when determining the operating mode of the cell image analysis device in the analysis mode set:
  • the analysis mode corresponding to the subject information is determined from the preset analysis mode set as the operating mode of the cell image analysis device.
  • the analysis mode corresponding to the subject information is the whole cell analysis mode. Determine from the preset analysis modes that the whole cell analysis mode is the operating mode of the cell image analysis device; if the analysis mode corresponding to the subject information is at least one of blood WBC analysis mode, blood RBC analysis mode, and blood PLT analysis mode
  • the analysis mode corresponding to the subject information among the blood WBC analysis mode, blood RBC analysis mode, and blood PLT analysis mode is used as the operation mode of the cell image analysis device.
  • the subject information includes, but is not limited to, at least one of department information, age, gender, medication status, and treatment status, based on one or more of the subject information through human-computer interaction.
  • Set the corresponding analysis mode For example, the department information can indicate the department to which the sample to be tested belongs.
  • the corresponding analysis mode can be set for at least one department.
  • the analysis mode corresponding to the pediatric department is the whole cell analysis mode.
  • the corresponding analysis modes are blood WBC analysis mode, blood RBC analysis mode, and blood PLT analysis mode; for example, the medication and treatment conditions can indicate the degree of the subject’s disease. If the subject’s degree of disease is severe, the The whole cell analysis mode is the analysis mode corresponding to the subject. If the subject has a milder disease, one of the blood WBC analysis mode, blood RBC analysis mode, and blood PLT analysis mode is used as the test subject Corresponding analysis mode.
  • the corresponding analysis mode can also be set for other information in the subject. This embodiment No longer explain one by one.
  • the analysis mode corresponding to the preset object of interest is the operating mode of the cell image analysis device. It should be noted that the analysis mode corresponding to the preset object of interest is set by the user according to actual needs; for example, the analysis mode corresponding to the preset object of interest is the whole-cell analysis mode.
  • the subject is a preset target of interest
  • the analysis mode corresponding to the preset target of interest is blood WBC analysis mode
  • the blood RBC analysis mode and the blood PLT analysis mode simultaneously determine the blood WBC analysis mode, the blood RBC analysis mode, and the blood PLT analysis mode from the preset analysis mode set as the operating mode of the cell image analysis device.
  • the department information in the subject information indicates that the sample to be tested comes from a preset department, it is determined from the preset analysis mode set that the analysis mode corresponding to the preset department is the operating mode of the cell image analysis device.
  • the analysis mode corresponding to the preset department is set by the user according to actual needs; for example, the analysis mode corresponding to the preset department is the whole cell analysis mode, if the department information in the subject information indicates If the sample to be tested comes from a preset department, it is determined from the preset analysis mode set that the whole cell analysis mode is set as the operating mode of the cell image analysis device; for another example, the analysis mode corresponding to the preset department is blood WBC analysis mode, blood RBC In the analysis mode and blood PLT analysis mode, the blood WBC analysis mode, blood RBC analysis mode, and blood PLT analysis mode are simultaneously determined as the operating mode of the cell image analysis device from the preset analysis mode set.
  • the control device 205 can also determine the operating mode of the cell image analysis device from the preset analysis mode set according to the sample information of the sample to be tested and the detection result information. For example, one way may be: if the sample information is The first analysis mode in the preset analysis mode set corresponds, and the detection result information corresponds to the second analysis mode different from the first analysis mode in the preset analysis mode set, then both the first analysis mode and the second analysis mode are set Set as the operating mode of the cell image analysis device.
  • the first analysis mode can be blood WBC analysis mode, blood RBC analysis mode, blood PLT analysis mode, and whole cell analysis mode.
  • the analysis mode corresponding to the current sample information, and the second analysis mode can be blood WBC analysis mode, blood RBC
  • the analysis mode corresponding to the sample information is the blood WBC analysis mode
  • the analysis mode corresponding to the detection result information is the blood RBC analysis mode
  • the control device can simultaneously determine the blood WBC analysis mode and the blood RBC analysis mode as the operating mode of the cell image analysis device .
  • the operation mode of the cell image analysis device may also include one or more than one.
  • the operating mode of the cell image analysis device is one, then after the image capture and analysis is completed in this operating mode, it waits for image capture and analysis of the next sample smear; if the operating mode of the cell image analysis device includes more than one, Such as two or three, etc., the cell image analysis device can sequentially take and analyze the same sample smear in multiple operating modes.
  • the operating modes of the cell image analysis device include blood WBC analysis mode and blood RBC
  • the cell image analysis device uses the above-mentioned blood WBC analysis mode and blood RBC analysis mode to capture images of the same sample smear, and analyzes each cell image after the shooting is completed, or uses the above-mentioned blood The shooting process of WBC analysis mode and blood RBC analysis mode.
  • each image can be analyzed immediately.
  • the sample can be continued in the remaining operating modes. Smears are taken for image shooting, so that analysis and image shooting can be carried out at the same time.
  • the operation mode of the cell image analysis device may be determined simultaneously or determined by time-sharing sequentially.
  • the control device 205 sequentially determines the number of cell image analysis devices by time-sharing.
  • An optional mode of operation mode is as follows:
  • the control device 205 is also configured to: if the cell image analysis device recognizes that there are other abnormalities in the sample smear in the operating mode, select the analysis mode corresponding to the other abnormalities from the preset analysis mode set as the additional operating mode, and use The cell image analysis device performs image capture and analysis on the sample smear in the additional operation mode, so as to realize the automatic addition of the operation mode of the cell image analysis device in the process of analyzing the sample smear.
  • Other abnormalities are different from the corresponding abnormalities in the operating mode.
  • the corresponding abnormalities in the operating mode are red blood cell abnormalities, and other abnormalities may be the abnormalities other than red blood cell abnormalities in the sample smear identified in the operating mode, such as white blood cells. Abnormalities and/or platelet abnormalities, etc.
  • the corresponding control device 205 is also used to: make the cell image analysis device complete the image capture and analysis of the sample smear in the operating mode, and then call the additional operating mode to perform image capture and analysis of the sample smear, even if the cell image analysis device is called sequentially Operation mode and additional operation mode are used for image capture and analysis of sample smears.
  • the control device 205 will further select the analysis mode corresponding to other abnormalities from the preset analysis mode set as another additional operation mode, so that After the cell image analysis device completes the image capture and analysis of the sample smear in the additional operation mode, another additional operation mode is called to perform image capture and analysis of the sample smear. If the abnormality identified by the cell image analysis device cannot be matched to the corresponding analysis mode in the preset analysis mode set, the control device 205 may issue a prompt message for instructing the user to select or input the operating mode of the cell image analysis device.
  • the prompt message sent by the control device 205 includes the analysis mode to be selected, and the analysis mode to be selected is different from any analysis mode in the preset analysis mode set.
  • the analysis mode to be selected can be provided to the user, such as output by the control device 205
  • the to-be-selected analysis mode is for the user to select the operating mode.
  • the manner in which the control device 205 outputs the analysis mode to be selected includes, but is not limited to, at least one output manner of display output, output through voice, and output through text.
  • the control device 205 can add an operation mode to the cell image analysis device when the cell image analysis device analyzes and recognizes other abnormalities, and causes the cell image analysis device to sequentially call the operation mode and the additional operation mode to the sample.
  • Smear is used for image shooting and analysis to realize the automatic determination and call of additional operating modes, so that the control device can add corresponding operating modes in real time according to the abnormalities in the sample smear during the analysis process of the cell image analysis device, and further guide the cell image
  • the analysis device adopts an operation mode matched with the abnormality for image shooting and analysis, which further improves the accuracy of the processing result.
  • the control device 205 is also used to: receive a mode setting instruction, the mode setting instruction includes the corresponding relationship between each analysis mode in the preset analysis mode set and the detection result information; wherein the mode setting instruction can be generated by the control device 205 or the control device 205 receives a mode setting instruction sent from a terminal independent of the sample analysis system.
  • the mode setting instruction can carry the corresponding relationship between each analysis mode in the combination of the preset analysis mode and the detection result information, so as to pass the corresponding relationship Indicate which analysis mode is used for the detection result information, or the mode setting instruction is used to instruct the setting of the corresponding relationship between each analysis mode in the preset analysis mode set and the detection result information, but the setting process can be received in the control device 205
  • the user sets the corresponding relationship between the two through the control device 205.
  • the control device 205 includes a display screen. The display screen displays the detection result information and each analysis mode in the preset analysis mode set, and then the user selects the detection result information and each analysis mode, so as to obtain the information of each analysis mode and detection result information in the preset analysis mode set. Correspondence.
  • the above-mentioned mode setting instructions can also be generated through human-computer interaction, such as by setting specific controls on the display screen (such as the corresponding relationship between each analysis mode and the detection result information in the preset analysis mode set). Control) operation to generate a mode setting instruction, or to generate a mode setting instruction after receiving a voice containing a specific word, such as receiving but not limited to "setting each analysis mode and detection result information in the preset analysis mode set" After the voice of "correspondence", a mode setting instruction is generated.
  • control device 205 In response to the mode setting instruction, the control device 205 establishes a mode setting rule according to the corresponding relationship; according to the mode setting rule and the detection result information of the sample to be tested, the operation mode of the cell image analysis device is determined from the preset analysis mode set.
  • the mode setting rule established according to the corresponding relationship can indicate the analysis mode corresponding to the detection result information. Then, after acquiring the detection result information of the current sample to be tested, the control device 205 can determine from the mode setting rule that the analysis mode corresponds to the current test result. The detection result information of the test sample matches (that is, the same) detection result information, and then the analysis mode corresponding to the matched detection result information is used as the operating mode of the cell image analysis device. Although the control device 205 needs to establish the mode setting rules in advance, this The mode setting rules can establish the corresponding relationship between the analysis mode and the detection result information based on the current medical needs. After the mode setting rules are set, the analysis mode that matches the detection result information of the current sample to be tested can be accurately determined as the cell image analysis The operating mode of the device improves accuracy.
  • FIG. 17 shows another optional structure of the sample analysis system provided by the embodiment of the present invention.
  • the sample analysis system 300 shown in FIG. 17 includes: a blood cell analyzer 301, a smear preparation device 302, and cell image analysis The device 303, the transport device 304, and the control device 305.
  • the blood cell analyzer 301 is used to perform detection on the sample to be tested to obtain detection result information.
  • the smear preparation device 302 is used to prepare smears of the sample to be tested.
  • the cell image analysis device 303 is used for image capture and analysis of the sample smear prepared by the smear preparation device.
  • the transport device 304 includes a first transport track 3041 and a second transport track 3042.
  • the first transport track 3041 is used to transport the sample to be tested from the blood cell analyzer to the smear preparation device, and the second transport track 3042 is used to coat the sample.
  • the slide is transported from the smear preparation device to the cell image analysis device.
  • the control device 305 is in communication connection with the blood cell analyzer 301, the smear preparation device 302, the cell image analysis device 303, and the transport device 304, and is configured to:
  • the mode designation interface is displayed; the mode selection instruction is received, and the mode selection instruction is used to instruct the user to select the operating mode of the cell image analysis device from the mode designation interface; in response to the mode Select instructions to control the first transport track to transport the sample to be tested to the smear preparation device, so that the smear preparation device prepares the sample smear of the sample to be tested; control the second transport track to transport the sample smear from the smear preparation device to the cell Image analysis device; control the cell image analysis device to call the selected transport mode to take and analyze the image of the sample smear.
  • the sample analysis system 300 shown in FIG. 17 can also target both types of samples, blood samples and body fluid samples, but the sample analysis system 300 shown in FIG.
  • the difference is that the control device 305 is aimed at the operation of the cell image analysis device during the re-examination of the detection result information of at least one of the blood sample and the body fluid sample.
  • the mode is determined, and in the re-examination of the detection result information of at least one type of blood sample and the body fluid sample, the user can learn the sample information of the sample to be tested for the current re-examination, so the sample shown in Figure 17
  • the analysis system 300 may not need the aforementioned sample information acquisition device 105.
  • the sample analysis system 300 shown in FIG. 17 can also include the aforementioned sample information acquisition device 105.
  • the sample information acquisition device 105 provides the control device 305 with a sample of the sample to be tested. information.
  • the corresponding re-inspection instruction input by the user according to the detection result information is when the user views the detection result information. If the user thinks that a re-inspection is necessary, the re-inspection instruction will be issued through the terminal on the user side, for example, by The re-inspection control on the terminal is operated to issue a re-inspection instruction, of course, the re-inspection instruction can also be issued through the user's voice input and gesture input.
  • the control device 305 After receiving the re-inspection instruction, the control device 305 responds to the re-inspection instruction to display the mode designation interface, where the mode designation interface can be displayed on the display screen of the control device 305 or output to other equipment through the control device 305 In the display, such as output to a projector through the control device 305, the interface is specified through the projection output mode of the projector.
  • the modes displayed on the mode designation interface include: blood analysis mode for image capture and analysis of cells in blood sample smears, and body fluid analysis mode that is different from blood analysis mode for image capture and analysis of cells in body fluid sample smears , And at least one of the whole-cell analysis modes that are different from the blood analysis mode and the body fluid analysis mode in which all cells in the designated area of the sample smear are imaged and analyzed, so that the user can use these analysis modes Select the operating mode of the cell image analysis device.
  • the mode of the mode designation interface display mode refer to FIG. 19, of course, other modes of display may also be adopted, which will not be described one by one in this embodiment.
  • the control device 305 After monitoring that the user selects the operating mode of the cell image analysis device, the control device 305 generates a mode selection instruction.
  • the function of the mode selection instruction is to instruct the user to select the operating mode of the cell image analysis device and instruct the cell image analysis device to start operating.
  • the sample smear is imaged and analyzed in the selected operating mode.
  • the method of shooting the sample smear by the cell image analysis device please refer to the description in the foregoing embodiment.
  • the sample analysis system can allow the user to intervene before preparing the sample smear.
  • the sample analysis system determines whether to prepare the sample smear through human-computer interaction, for example, when the sample to be tested passes through the blood
  • the test result information obtained by the cell analyzer shows that the result is normal.
  • the sample to be tested does not need to prepare sample smears, but the doctor can still decide that the sample smear can be prepared based on the test result information of the sample to be tested.
  • the sample analysis system can control the smear preparation device to prepare the sample smear, which brings convenience to the re-examination.
  • the blood analysis mode further includes: a blood WBC analysis mode for image capture and analysis of white blood cells in a blood sample smear, a blood RBC analysis mode for image capture and analysis of red blood cells in a blood sample smear, At least one of the blood PLT analysis modes for image capture and analysis of the platelets in the blood sample smear, so that the control device 305 can further display the blood WBC analysis mode on the mode designation interface when learning that the current sample to be tested is a blood sample At least one of the blood RBC analysis mode and the blood PLT analysis mode, as shown in Figure 18, the blood WBC analysis mode, the blood RBC analysis mode and the blood PLT analysis mode are displayed on the mode designation interface to realize the operation mode corresponding to the blood sample In this way, the user can select different analysis modes for different abnormalities in the blood sample during the re-examination, and guide the cell image analysis device to perform image capture and analysis for different abnormalities in the blood sample. Compared with the existing blood samples The different abnormalities of the samples are all used in
  • the body fluid analysis mode further includes: at least one of a body fluid WBC analysis mode for image capture and analysis of white blood cells in a body fluid sample smear and a body fluid RBC analysis mode for image capture and analysis of red blood cells in a body fluid sample smear, the same
  • the control device 305 can further display at least one of the body fluid WBC analysis mode and the body fluid RBC analysis mode on the mode designation interface when it learns that the current sample to be tested is a body fluid sample, so as to further refine the operation mode corresponding to the body fluid sample.
  • the user can select different analysis modes for different abnormalities in the body fluid sample, and guide the cell image analysis device to take and analyze the different abnormalities of the body fluid sample. Compared with the existing different abnormalities of the body fluid sample, it is adopted.
  • the processing efficiency and accuracy of the cell image analysis device are further improved.
  • the control device 305 can acquire the sample information of the sample to be tested from the sample information acquisition device 105, and then the control device 305 responds to the re-inspection instruction
  • the mode designation interface directly displays the analysis mode corresponding to the sample type information in the sample information of the sample to be tested
  • the control device 305 controls the mode designation interface to directly display the blood sample analysis mode The included analysis modes.
  • the control device 305 controls the mode designation interface to directly display the analysis modes included in the body fluid sample analysis mode.
  • the cell image analysis device can perform image capture and analysis of all cells in the designated area of the sample smear of at least one type of blood sample and body fluid sample. Therefore, for blood samples, While displaying the analysis modes included in the blood analysis mode, the whole cell analysis mode can also be displayed.
  • control device 305 can also perform the addition of the operating mode, where the addition of the operating mode is that the cell image analysis device performs image capture and analysis of the sample smear before the selected operating mode is completed, or the cell image analysis device During the process of image capture and analysis of the sample smear in the selected operating mode, the optional method for the control device 305 to add the operating mode is as follows:
  • the control device 305 is also configured to: in response to an additional recheck instruction input by the user according to the test result information of the sample to be tested, display a mode designation interface; receive an additional mode selection instruction, the additional mode selection instruction is used to instruct the user to select from the mode designation interface The additional operation mode of the cell image analysis device is selected; in response to the additional mode selection instruction, the cell image analysis device completes the image capture and analysis of the sample smear in the selected operation mode and then calls the additional operation mode to image the sample smear Filming and analysis.
  • the additional re-inspection instruction is similar to the re-inspection instruction. After receiving the additional re-inspection instruction, the display of the mode designation interface is the same as that of the mode designation interface after receiving the re-inspection instruction.
  • the additional mode selection instruction received in 305 is used to instruct the user to select an additional operating mode from the mode designation interface that is different from the previous operating mode, so that the cell image analysis device can apply the sample in two or more modes. Film for image capture and analysis.
  • the mode designation interface is displayed, and the user selects the operating mode of the cell image analysis device from the preset analysis mode set.
  • FIG. 19 an optional structure of the control device in each sample analysis system is shown in FIG. 19, which includes at least: processing component 111, RAM112, ROM113, communication The interface 114, the memory 116, and the I/O interface 115, wherein the processing component 111, the RAM 112, the ROM 113, the communication interface 114, the memory 116, and the I/O interface 115 communicate through the bus 117.
  • the processing component can be a CPU, GPU or other chips with computing capabilities.
  • the memory 116 is loaded with various computer programs such as an operating system and application programs for the processor component 111 to execute, and data required to execute the computer programs. In addition, during the sample detection process, any information that needs to be stored locally can be stored in the memory 116.
  • the I/O interface 115 is composed of a serial interface such as USB, IEEE1394 or RS-232C, a parallel interface such as SCSI, IDE or IEEE1284, and an analog signal interface composed of a D/A converter and an A/D converter.
  • An input device composed of a keyboard, a mouse, a touch screen or other control buttons is connected to the I/O interface 115, and the user can use the input device to directly input data to the control device 110.
  • the I/O interface 115 can also be connected to a display with display functions, such as: LCD screen, touch screen, LED display, etc.
  • the control device can output information to the display for display in an image display mode, for example: analysis mode , Test result information, etc.
  • the communication interface 114 is an interface that can be any currently known communication protocol.
  • the communication interface 114 communicates with the outside world through the network.
  • the control device can transmit data to any device connected through the network through the communication interface 114 using a certain communication protocol.
  • the blood cell analyzer 201 performs blood routine testing on the blood sample to be tested on the test tube rack, and obtains the detection result information of the blood sample to be tested.
  • the control device 205 obtains the detection result information of the sample to be tested from the blood cell analyzer 201.
  • control device 205 determines that the detection result information indicates abnormal result information according to the detection result information, if the detection result information indicates white blood cell abnormality information, this The time control device 205 controls the first transport track to transport the blood sample to be tested to the smear preparation device 202, so that the smear preparation device 202 prepares the sample smear of the sample to be tested; then controls the second transport track to transfer the sample smear from The smear preparation device 202 is transported to the cell image analysis device 203.
  • the control device 205 further determines the operation mode of the cell image analysis device from the preset analysis mode set according to the detection result information of the sample to be tested. For example, if the detection result information indicates that the white blood cell is abnormal, the control device 205 uses the blood WBC analysis mode as the cell image The operating mode of the analysis device 203, and controls the cell image analysis device to perform image capture and analysis of the sample smear in the operating mode. For example, the method shown in Figure 8 to Figure 10 is used for image capture, and the captured cell image is performed analysis.
  • FIG. 20 shows an optional flowchart of a sample analysis method provided by an embodiment of the present invention, which may include:
  • the sample analysis method provided by this embodiment can determine the operating mode of the cell image analysis device from the preset analysis mode set according to at least one of the sample information of the sample to be tested and the detection result information of the sample to be tested, so as to realize the operation Automatic determination of the mode.
  • the description of each step in the sample analysis method provided in this embodiment please refer to the foregoing system embodiment, which will not be elaborated in this embodiment.
  • An embodiment of the present invention also provides a storage medium storing executable instructions, configured to cause a processor to execute the executable instructions to implement the above-mentioned sample analysis method.
  • the embodiments of the present invention may be provided as a method, a system, or a computer program product. Therefore, the embodiments of the present invention may adopt the form of a hardware embodiment, a software embodiment, or an embodiment combining software and hardware. Moreover, the embodiments of the present invention may adopt the form of a computer program product implemented on one or more computer-usable storage media (including disk storage, optical storage, etc.) containing computer-usable program codes.
  • a computer-usable storage media including disk storage, optical storage, etc.
  • These computer program operations can also be stored in a computer-readable memory that can guide a computer or other programmable data processing equipment to work in a specific manner, so that the operations stored in the computer-readable memory produce an article of manufacture including the operating device.
  • the device implements the functions specified in one process or multiple processes in the flowchart and/or one block or multiple blocks in the block diagram.

Abstract

本发明一种样本分析系统及方法，样本分析系统包括：血液细胞分析仪、涂片制备装置、细胞图像分析装置、运送装置、样本信息获取装置和控制装置，控制装置配置用于从血液细胞分析仪获取检测结果信息以及从样本信息获取装置获取样本信息，当检测结果信息满足预定条件时，控制运送装置中的第一运送轨道将待测样本运送至涂片制备装置，以便涂片制备装置制备样本涂片，控制运送装置的第二运送轨道将样本涂片从涂片制备装置运送到细胞图像分析装置；并根据待测样本的样本信息，从预设分析模式集合中确定细胞图像分析装置的运行模式，控制细胞图像分析装置在运行模式下对样本涂片进行图像拍摄和分析，由此实现自动确定细胞图像分析装置的运行模式。

Description

样本分析系统及方法 技术领域
本发明涉及医疗设备技术，尤其涉及一种样本分析系统及方法。
背景技术
血液细胞分析仪(hematology analyzers)是一种可检测血液样本和体液样本中细胞的仪器，例如可以对血液样本和体液样本中的白细胞(WBC)、红细胞(RBC)、血小板(PLT)、有核红细胞和网织红细胞等细胞进行检测，以确定血液样本和体液样本中的细胞是否有异常。若细胞的检测结果异常则对检测结果异常的样本进行推片染色，得到样本涂片，再利用显微镜进行人工镜检或利用细胞图像分析装置(如阅片机)对样本涂片进行图像拍摄和分析。
目前细胞图像分析装置在对样本涂片进行图像拍摄和分析之前，需要指定细胞图像分析装置的运行模式，其中细胞图像分析装置的运行模式的指定方式如图1所示，在细胞图像分析装置的显示区域显示模式指定界面，由用户在模式指定界面上选择当前样本涂片对应的分析模式为细胞图像分析装置的运行模式，然后细胞图像分析装置在所选择的运行模式下进行图像拍摄和分析。每个样本涂片出现异常的种类不尽相同，在预设统一的模式进行阅片，在一定程度上导致分析结果的准确性不高。此外，若每一样本涂片都通过人工设定细胞图像分析装置的运行模式，则导致细胞图像分析装置的处理效率不高。
发明内容
本发明实施例提供一种样本分析系统及方法，以自动确定细胞图像分析装置的运行模式，提高处理效率和处理结果的准确度。
本发明实施例的技术方案通过如下方式实现：
一方面，本发明实施例提供一种样本分析系统，包括：
血液细胞分析仪，用于对待测样本进行检测以获取检测结果信息；
涂片制备装置，用于制备所述待测样本的样本涂片；
细胞图像分析装置，用于对由所述涂片制备装置制备的样本涂片进行图像拍摄和分析；
运送装置，包括第一运送轨道和第二运送轨道，第一运送轨道用于将所述待测样本从所述血液细胞分析仪运送到所述涂片制备装置，第二运送轨道用于将所述样本涂片从所述涂片制备装置运送到所述细胞图像分析装置；
样本信息获取装置，用于获取所述待测样本的样本信息；
控制装置，与所述血液细胞分析仪、所述涂片制备装置、所述细胞图像分析装置、所述运送装置 和所述样本信息获取装置通信连接，并且配置用于：
从所述血液细胞分析仪获取所述检测结果信息以及从所述样本信息获取装置获取所述待测样本的样本信息；
当所述检测结果信息满足预定条件时，控制所述第一运送轨道将所述待测样本运送至所述涂片制备装置，以便所述涂片制备装置制备所述待测样本的样本涂片；
控制所述第二运送轨道将所述样本涂片从所述涂片制备装置运送到所述细胞图像分析装置；
根据所述待测样本的样本信息，从预设分析模式集合中确定所述细胞图像分析装置的运行模式；
控制所述细胞图像分析装置在所述运行模式下对所述样本涂片进行图像拍摄和分析。
另一方面，本发明实施例提供一种样本分析系统，包括：
血液细胞分析仪，用于对待测样本进行检测以获取检测结果信息；
涂片制备装置，用于制备所述待测样本的样本涂片；
细胞图像分析装置，用于对由所述涂片制备装置制备的样本涂片进行图像拍摄和分析；
运送装置，包括第一运送轨道和第二运送轨道，第一运送轨道用于将所述待测样本从所述血液细胞分析仪运送到所述涂片制备装置，第二运送轨道用于将所述样本涂片从所述涂片制备装置运送到所述细胞图像分析装置；
控制装置，与所述血液细胞分析仪、所述涂片制备装置、所述细胞图像分析装置和所述运送装置通信连接，并且配置用于：
从所述血液细胞分析仪获取所述待测样本的检测结果信息，当所述检测结果信息满足预定条件时，控制所述第一运送轨道将所述待测样本运送至所述涂片制备装置，以便所述涂片制备装置制备所述待测样本的样本涂片；
控制所述第二运送轨道将所述样本涂片从所述涂片制备装置运送到所述细胞图像分析装置；
根据所述待测样本的样本信息和/或检测结果信息，从预设分析模式集合中确定所述细胞图像分析装置的运行模式；
控制所述细胞图像分析装置在所述运行模式下对所述样本涂片进行图像拍摄和分析。
再一方面，本发明实施例提供一种样本分析系统，包括：
血液细胞分析仪，用于对待测样本进行检测以获取检测结果信息；
涂片制备装置，用于制备所述待测样本的涂片；
细胞图像分析装置，用于对由所述涂片制备装置制备的样本涂片进行图像拍摄和分析；
运送装置，包括第一运送轨道和第二运送轨道，第一运送轨道用于将所述待测样本从所述血液细 胞分析仪运送到所述涂片制备装置，第二运送轨道用于将所述样本涂片从所述涂片制备装置运送到所述细胞图像分析装置；
控制装置，与所述血液细胞分析仪、所述涂片制备装置、所述细胞图像分析装置和所述运送装置通信连接，并且配置用于：
响应于用户根据所述检测结果信息输入的相应的复检指令，显示模式指定界面；
接收模式选择指令，所述模式选择指令用于指示用户从所述模式指定界面中选择出细胞图像分析装置的运行模式；
响应于所述模式选择指令，控制所述第一运送轨道将所述待测样本运送至所述涂片制备装置，以便所述涂片制备装置制备所述待测样本的样本涂片；
控制所述第二运送轨道将所述样本涂片从所述涂片制备装置运送到所述细胞图像分析装置；
控制所述细胞图像分析装置调用所选择的运行模式对所述样本涂片进行图像拍摄和分析。
再一方面，本发明实施例提供一种样本分析方法，包括：
获取待测样本的样本信息和血液细胞分析仪对所述待测样本的检测结果信息中的至少一种信息；
通过控制装置根据所获取的至少一种信息，从预设分析模式集合中确定细胞图像分析装置的运行模式；
使细胞图像分析装置调用所述运行模式对由涂片制备装置制备的待测样本的样本涂片进行图像拍摄和分析。
在本发明实施例中，样本分析系统包括：血液细胞分析仪、涂片制备装置、细胞图像分析装置、运送装置、样本信息获取装置和控制装置，控制装置配置用于从血液细胞分析仪获取待测样本的检测结果信息以及从样本信息获取装置获取待测样本的样本信息，当检测结果信息满足预定条件时，控制运送装置中的第一运送轨道将待测样本运送至涂片制备装置，以便涂片制备装置制备待测样本的样本涂片，控制运送装置的第二运送轨道将样本涂片从涂片制备装置运送到细胞图像分析装置；并根据待测样本的样本信息，从预设分析模式集合中确定细胞图像分析装置的运行模式，控制细胞图像分析装置在运行模式下对样本涂片进行图像拍摄和分析，由此实现自动确定细胞图像分析装置的运行模式，这样在每获取到一个待测样本，都可以通过样本分析系统中的控制装置自动确定细胞图像分析装置针对该样本涂片的运行模式，使得细胞图像分析装置能够根据样本信息指导细胞图像分析装置进行图像拍摄和分析，即针对不同的样本涂片根据该样本涂片匹配的运行模式指导细胞图像分析装置进行图像拍摄和分析，提高细胞图像分析装置的处理效率和处理结果的准确度。
附图说明
为了更清楚地说明本发明实施例或现有技术中的技术方案，下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图是本发明的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他的附图。
图1是现有模式指定界面的一种可选的示意图；
图2是本发明实施例提供的样本分析系统的一种可选的结构示意图；
图3是本发明实施例提供的检测结果信息的一种可选示意图；
图4是本发明实施例提供的检测结果信息的另一种可选示意图；
图5和图6是本发明实施例提供的样本分析系统中细胞图像分析装置的一种可选的结构示意图；
图7是本发明实施例提供的全细胞分析模式的一种可选的拍摄方式示意图；
图8至图10是本发明实施例提供的血液WBC分析模式的一种可选的拍摄方式示意图；
图11是本发明实施例提供的血液RBC分析模式的一种可选的拍摄方式示意图；
图12是本发明实施例提供的血液PLT分析模式的一种可选的拍摄方式示意图；
图13至图15是本发明实施例提供的体液WBC分析模式的一种可选的拍摄方式示意图；
图16是本发明实施例提供的样本分析系统的另一种可选的结构示意图；
图17是本发明实施例提供的样本分析系统的再一种可选的结构示意图；
图18是本发明实施例提供的模式指定界面的一种可选显示方式示意图；
图19是本发明实施例提供的样本分析系统中控制装置的一种可选的结构示意图；
图20是本发明实施例提供的样本分析方法的一种可选的流程图。
具体实施方式
为了使本发明的目的、技术方案和优点更加清楚，下面将结合附图对本发明作进一步地详细描述。本发明不应被理解为局限于所提供的实施例，相反，本发明实施例所记载的内容使得本发明全面和完整，并将本发明实施例构思传达给本领域技术人员，因此本领域普通技术人员在没有做出创造性劳动前提下所获得的其他实施例，都属于本发明保护的范围。
需要说明的是，在本公开实施例中，术语“包括”、“包含”或者其任何其他变体意在涵盖非排他性的包含，从而使得包括一系列要素的方法或者服务器不仅包括所明确记载的要素，而且还包括没有明确列出的其他要素，或者是还包括为实施方法或者服务器所固有的要素。在没有更多限制的情况下，由语句“包括一个……”限定的要素，并不排除在包括该要素的方法或者服务器中还存在另外的相关要素(例如方法中的步骤或者服务器中的单元，例如的单元可以是部分电路、部分处理器、部分程序或软件等等)。
例如，本公开实施例提供的样本分析系统包含一系列装置，但是本公开实施例提供的样本分析系统不限于包括所明确记载的装置，同样的，本公开实施例提供的样本分析方法包含了一系列的步骤，但是本公开实施例提供的样本分析方法不限于所记载的步骤。需要说明，在以下的描述中，涉及到“实施例”，其描述了所有可能实施例的子集，但是可以理解，“实施例”可以是所有可能实施例的相同子集或不同子集，并且可以在不冲突的情况下相互结合。
对本发明进行进一步详细说明之前，对本发明实施例中涉及的名词和术语进行说明，本发明实施例中涉及的名词和术语适用于如下的解释。
1)响应于，用于表示所执行的操作所依赖的条件或者状态，当满足所依赖的条件或状态时，所执行的一个或多个操作可以是实时的，也可以具有设定的延迟；在没有特别说明的情况下，所执行的多个操作不存在执行先后顺序的限制。
2)样本涂片，即涂抹标本的基片，例如均匀涂抹血液样本并对其中的细胞染色后的玻璃片。
请参阅图2，其示出了本发明实施例提供的一种样本分析系统的可选结构，如图2所示样本分析系统100可以包括：血液细胞分析仪101、涂片制备装置102、细胞图像分析装置103、运送装置104、样本信息获取装置105和控制装置106。
血液细胞分析仪101，用于对待测样本进行检测以获取检测结果信息。其中待测样本可以是血液样本、体液样本等需要进行各种细胞数量检查(如血常规)的样本，如血液细胞分析仪能够对血液样本和体液样本中的至少一种样本进行血常规检测，以对血液样本和体液样本中的至少一种样本中的WBC、RBC和PLT中的至少一种类型的细胞进行检测。
在本实施例中，血液细胞分析仪101在对待测样本进行检测之后输出待测样本的检测结果信息，待测样本的检测结果信息可以是：待测样本中各类型细胞的细胞检测参数和针对各类型细胞的细胞检测参数进一步检测出的是否异常的信息中的至少一种，如图3所示，血液细胞分析仪101在对待测样本进行检测之后输出该待测样本包含的各细胞的细胞检测参数对应的数值。此外血液细胞分析仪101还根据各细胞检测参数对应的数值和各细胞检测参数对应的阈值，判断出数值是否存在异常，如果存在异常则会标注对应数值异常，如图4所示检测结果信息，其是对图3所示数值进行分析判断之后输出的另一个形式的检测结果信息，其示出图3所示检测结果中有一个细胞检测参数对应的数值异常，如图4中的细胞2异常；血液细胞分析仪除能够根据各细胞检测参数对应的数值和各细胞检测参数对应的阈值进行异常判断之外，还可以通过其他方式进行异常判断，如直接根据细胞检测参数对应的数值进行判断，如细胞检测参数缺省(例如细胞检测参数为空或者细胞检测参数对应的数值为初始值)、细胞检测参数对应的数值直接显示异常等等，对此本实施例不对判断异常的方式进行限定。
涂片制备装置102，用于制备待测样本的样本涂片，以对待测样本中的特定细胞，如异常细胞进行有针对性的分析。在本实施例中涂片制备装置102通过推片染色等操作得到待测样本的样本涂片，但是此处需要说明的一点是：目前在制备体液样本的样本涂片时需要通过甩片操作甩出一个特定形状的区域，如甩出一个圆形区域，针对体液样本的样本涂片的这一特点，涂片制备装置102可以包括用于对血液样本进行涂片制备的第一制备装置(如推片机)和包括用于对体液样本进行涂片制备的第二制备装置(如离心甩片机)，当涂片制备装置获取到一个待测样本时，如果待测样本为血液样本，则将待测样本输送至第一制备装置(如推片机)，如果根据待测样本为体液样本，则将待测样本输送至第二制备装置(如离心甩片机)，或者血液细胞分析仪101能够获知待测样本的样本类型，当血液细胞分析仪101确定待测样本为血液样本，直接将该待测样本输送至第一制备装置；当血液细胞分析仪101确定待测样本为体液样本，直接将该待测样本输送至第二制备装置。
对于任一类型的待测样本，涂片制备装置102制备的样本涂片和血液细胞分析仪101获取到的检测结果信息之间建立对应关系，以指示样本涂片和检测结果信息属于同一受试者的同一待测样本，建立两者之间的对应关系的一种方式是：通过待测样本的样本标识信息(如样本编号)将样本涂片和检测出结果信息对应，例如在样本涂片上设置一个标签区域，该标签区域用于设置样本标识信息，如涂片制备装置102从血液细胞分析仪101中获取样本标识信息，将样本标识信息设置在标签区域，如涂片制备装置102具备生成二维码的功能，将样本标识信息以二维码形式展示，将生成的二维码打印在标签区域。
细胞图像分析装置103，用于对由涂片制备装置102制备的样本涂片进行图像拍摄和分析，尤其是通过拍摄样本涂片的细胞图像对样本涂片中的细胞进行识别定位，然后再对识别定位后的细胞进行图像拍摄和分析。其中细胞图像分析装置103的一种可选的结构如图5和图6所示，细胞图像分析装置103至少包括成像装置1031、涂片移动装置1032和图像分析装置1033。
成像装置1031包括相机10312和透镜组10311，并且用于对样本涂片上涂抹的待测样本中的细胞进行拍摄，涂片移动装置1032用于使样本涂片相对于成像装置1031运动，以便成像装置1031拍摄样本涂片的特定区域的细胞图像，图像分析装置1033用于对样本涂片的细胞图像进行分析。
如图6所示，透镜组10311可以包括第一物镜3111和第二物镜3112。第一物镜3111和第二物镜3112中的一个物镜为低倍物镜，另一个为高倍物镜，例如第一物镜3111为低倍物镜，第二物镜3112为高倍物镜，如第一物镜可以为10倍物镜，第二物镜3112可以为100倍物镜。透镜组10311还可以包括第三物镜3113，第三物镜3113的倍数介于第一物镜和第二物镜的倍数之间，例如第三物镜3113可以为40倍物镜。
细胞图像分析装置103还包括识别装置1034、涂片夹取装置1035和涂片回收装置1036。识别装置1034用于识别样本涂片的样本标识信息，涂片夹取装置1035用于将样本涂片从识别装置1034夹取到涂片移动装置1032上，以通过涂片移动装置1032带动样本涂片相对于成像装置1031运动，进一步在成像装置1031拍摄得到样本涂片的细胞图像后由图像分析装置1033对样本涂片的细胞图像进行分析，涂片回收装置1036用于放置经图像分析装置1033完成分析的样本涂片。
细胞图像分析装置103还包括涂片篮装载装置1037，用于装载装有待测的样本涂片的涂片篮，涂片夹取装置1035还用于将涂片篮装载装置1037上装载的涂片篮中的样本涂片夹取到识别装置1034进行样本信息识别。涂片篮装载装置1037与运送装置104连接，以便由涂片制备装置102制备的样本涂片能够运送至细胞图像分析装置103。
运送装置104，包括第一运送轨道1041和第二运送轨道1042，第一运送轨道1041用于将待测样本从血液细胞分析仪101运送到涂片制备装置102，第二运送轨道1042用于将样本涂片从涂片制备装置102运送到细胞图像分析装置103，以通过第一运送轨道1041和第二运送轨道1042完成待测样本在血液细胞分析仪101、涂片制备装置102和细胞图像分析装置103之间的传送，这样任一待测样本通过血液细胞分析仪101、涂片制备装置102和细胞图像分析装置103能够完成自动检测、制备样本涂片、图像拍摄和分析。
其中，第一运送轨道1041和第二运送轨道1042可以是同一运送轨道的两部分，或者第一运送轨道1041和第二运送轨道1042可以是两个独立的运送轨道，但是这两个独立的运送轨道之间连接有一个转移轨道，用于将在涂片制备装置102制备成样本涂片之后，将样本涂片从第一运送轨道1041上转移到第二运送轨道1042上，对于第一运送轨道1041和第二运送轨道1042来说，能够实现样本传输的轨道均可，因此本实施例不对第一运送轨道1041和第二运送轨道1042的构成进行限定和详细说明。
样本信息获取装置105，用于获取待测样本的样本信息。在本实施例中，待测样本的样本信息用于标识待测样本，如用于标识待测样本的样本类型、待测样本所属受试者中的至少一种，类似与上述待测样本的样本标识信息，以通过样本信息可以确定待测样本所属样本类型、待测样本所属受试者(即待测样本是从哪个用户身体上采集到)，进一步的还能够标识待测样本所属受试者归属于的科室(即标识待测样本是由哪个科室送检)。
在本实施例中，样本信息获取装置105获取待测样本的样本信息的一种方式是：样本信息获取装置105与上述血液细胞分析仪101、涂片制备装置102和细胞图像分析装置103中的至少一个装置通信连接，以从这些装置中获取待测样本的样本信息或者由这些装置将待测样本的样本信息发送给样本信息获取装置105。但是样本分析系统可以依次处理多个待测样本，而一个待测样本从血液细胞分析仪 101到细胞图像分析装置103可能会经过一段时间，使得血液细胞分析仪101当前发送的样本信息和细胞图像分析装置当前发送的样本信息所针对的待测样本不是同一个样本，因此在本实施例中样本信息获取装置105可选的从细胞图像分析装置103处获取样本信息。
此外上述血液细胞分析仪101、涂片制备装置102和细胞图像分析装置103也可以与本实施例中的控制装置105通信连接，待测样本的样本信息也可以传输到控制装置105中，基于此本实施例中的样本信息获取装置105可以集成到控制装置105中。
在本实施例中，样本信息获取装置105获取待测样本的样本信息的另一种方式是：样本信息获取装置105对样本涂片的标签区域进行扫描，以获取待测样本的样本信息，如样本信息获取装置105可以包括/连接一个摄像头，通过摄像头对标签区域中的二维码进行扫描，以获取待测样本的样本类型信息和/或待测样本所属受试者。
在本实施例中，样本信息获取装置105获取待测样本的样本信息的再一种方式是：样本信息获取装置105对样本涂片的标签区域进行扫描，获取样本涂片的标签区域的样本标签信息(如上述二维码)，将样本标签与样本库中各个历史样本的样本标签信息进行比对，以查找到相同的样本标签信息，将相同的样本标签信息的历史样本的样本信息作为当前待测样本的样本信息。
控制装置106，与血液细胞分析仪101、涂片制备装置102、细胞图像分析装置103、运送装置104和样本信息获取装置105通信连接，以控制上述各个装置的动作，尤其是控制上述运送装置104和细胞图像分析装置103动作，并和与上述各个装置中的部分装置交互，控制装置106的处理过程如下：
从血液细胞分析仪获取检测结果信息以及从样本信息获取装置获取待测样本的样本信息；当检测结果信息满足预定条件时，控制第一运送轨道将待测样本运送至涂片制备装置，以便涂片制备装置制备待测样本的样本涂片；控制第二运送轨道将样本涂片从涂片制备装置运送到细胞图像分析装置；根据待测样本的样本信息，从预设分析模式集合中确定细胞图像分析装置的运行模式；控制细胞图像分析装置在运行模式下对样本涂片进行图像拍摄和分析。
在本实施例中，检测结果信息和待测样本的样本信息可以由控制装置106主动获取，或者由血液细胞分析仪101和样本信息获取装置105主动发送给控制装置106。由于检测结果信息和待测样本的样本信息的使用时机不同，所以控制装置106可以分时获取检测结果信息和待测样本的样本信息，例如在血液细胞分析仪101获取到检测结果信息时获取，当样本涂片运送至细胞图像分析装置103时获取待测样本的样本信息。当然控制装置106也可以同时获取检测结果信息和待测样本的样本信息，对此本实施例不进行限定。
控制装置106确定检测结果信息满足预定条件时说明需要对待测样本中的细胞进行分析，此时控制装置106会控制运送装置104的第一运送轨道将待测样本运送至涂片制备装置102，在涂片制备装置102制备成样本涂片之后，控制运送装置104的第二运送轨道将样本涂片运送至细胞图像分析装置103。其中预定条件可以包括但不限于如下至少一种：
预定条件的一种可选方式是：检测结果信息包含表明待测样本出现异常的异常结果信息，该异常结果信息可以是由血液细胞分析仪101直接对待测样本检测得出，或者是由控制装置106根据血液细胞分析仪101的检测结果信息得出，并且异常结果信息可以包括但不限于如下信息的至少一种：待测样本的细胞检测参数对应的数值异常、待测样本中存在异常细胞、在设定间隔时间内从同一受试者获取的各个待测样本的同一细胞参数之间的差值超出预设范围。
其中，待测样本的细胞检测参数对应的数值异常主要表明一个细胞检测参数异常，如细胞检测参数对应的数值不满足对应的阈值(如大于阈值或不在阈值范围内)、细胞检测参数缺省(例如细胞检测参数为空或者细胞检测参数对应的数值为初始值)、细胞检测参数对应的数值直接表示是否存在异常(例如不需要通过阈值方式确定)等等都视为是细胞检测参数对应的数值异常。待测样本中存在异常细胞表明待测样本本身就是一个异常样本，如待测样本中存在异型淋巴细胞，因此该待测样本直接判断为异常的样本。
对于同一受试者(即患者)来说，其同一类型的待测样本在一定时间内不会出现大幅度变化，因此若在设定间隔时间内从同一受试者获取的各个待测样本的同一细胞参数之间的差值超出预设范围，说明该受试者的待测样本的同一细胞参数在设定间隔时间内出现大幅度变化，此时也会视为出现异常。在这里需要说明的一点是：如果在设定间隔时间内细胞参数的数值在正常范围内，但是其差值超出预设范围，同样判断为待测样本出现异常的异常结果信息，其中设定间隔时间和预设范围取值可以根据待测样本的样本类型信息和待测样本中的细胞参数确定，对此本实施例不一一说明。
预定条件的另一种方式是：检测结果信息中包含特定类型异常细胞参数，如检测结果信息中包含但不限于包含特定类型的异常的白细胞，对于特定类型细胞参数本实施例不进行限定。
预定条件的再一种方式是：检测结果信息所属受试者为预设关注对象，如检测结果信息来源于但不限于来源于患有白细胞疾病的患者的待测样本，其中预设关注对象可根据医疗需求而定，本实施例不进行限定。预定条件的再一种方式是：检测结果信息对应的待测样本来源于特定科室，如检测结果信息来源于但不限于来源于生殖医学科，对于特定科室可根据医疗需求而定，本实施例不进行限定。
上述介绍预定条件的几种可选方式，在本实施例中不限定预定条件。此外控制装置106在控制待测样本从血液细胞分析仪101至涂片制备装置102的过程中，控制装置106如果确定待测样本为血液 样本，则通过第一运送轨道的第一支路将待测样本运送至涂片制备装置的第一制备装置，如果确定待测样本为体液样本，则通过第一运送轨道的第二支路将待测样本运送至涂片制备装置的第二制备装置。
控制装置106确定细胞图像分析装置的运行模式的时机可以是：在第二运送轨道将样本涂片从涂片制备装置运送到细胞图像分析装置过程中、在第二运送轨道将样本涂片从涂片制备装置运送到细胞图像分析装置之前、在第二运送轨道将样本涂片从涂片制备装置运送到细胞图像分析装置之后、控制装置106获取到待测样本的样本信息之后中的任意一个时机。相对应的上述预设分析模式集合中可包括至少两个分析模式，由控制装置106从至少两个分析模式中获取与待测样本的样本信息匹配的分析模式为细胞图像分析装置的运行模式。
其中，预设分析模式集合包括的至少两个分析模式可以是针对不同类型的样本，和/或针对同一类型样本的不同类型细胞，该预设分析模式集合中的分析模式可以在实施样本分析系统之前或者过程中设置调整，以适应不同样本的检测需求。例如通过控制装置106包括一个人机交互装置，如显示屏、摄像头等等，通过人机交互装置响应于人机交互指令，以在样本涂片分析之前通过用户介入方式提前设置调整预设分析模式集合中的分析模式，该提前设置调整的预设分析模式集合能够在使用本实施例提供的样本分析系统时自动从预设分析模式集合中确定细胞图像分析装置的运行模式。
控制装置106在确定细胞图像分析装置的运行模式之后，控制细胞图像分析装置在该运行模式下对样本涂片进行图像拍摄和分析，即本实施例首先确定细胞图像分析装置进行图像拍摄和分析的运行模式，然后在该运行模式下指导对样本涂片的拍摄和指导对拍摄到的样本涂片的细胞图像的分析。其中指导对样本涂片的拍摄包括但不限于：拍摄区域、拍摄过程中使用到的物镜、拍摄过程中使用到的物镜的先后顺序和对拍摄区域的扫描定位方式等中的至少一种，对于不同类型的待测样本来说，其拍摄样本涂片的过程会有所不同，后面会结合附图详细说明。
在本发明实施例中，样本分析系统包括：血液细胞分析仪、涂片制备装置、细胞图像分析装置、运送装置、样本信息获取装置和控制装置，控制装置配置用于从血液细胞分析仪获取待测样本的检测结果信息以及从样本信息获取装置获取待测样本的样本信息，当检测结果信息满足预定条件时，控制运送装置中的第一运送轨道将待测样本运送至涂片制备装置，以便涂片制备装置制备待测样本的样本涂片，控制运送装置的第二运送轨道将样本涂片从涂片制备装置运送到细胞图像分析装置；并根据待测样本的样本信息，从预设分析模式集合中确定细胞图像分析装置的运行模式，控制细胞图像分析装置在运行模式下对样本涂片进行图像拍摄和分析，由此实现自动确定细胞图像分析装置的运行模式，这样在每获取到一个待测样本，都可以通过样本分析系统中的控制装置自动确定细胞图像分析装置针对该样本涂片的运行模式，使得细胞图像分析装置能够根据样本信息指导细胞图像分析装置进行图像 拍摄和分析，即针对不同的样本涂片根据该样本涂片匹配的运行模式指导细胞图像分析装置进行图像拍摄和分析，提高细胞图像分析装置的处理效率和处理结果的准确度，克服目前在人工指定的运行模式下对样本涂片进行相同的图像拍摄和分析带来的处理效率低的问题，同时也克服了目前设置统一的样本涂片分析模式所带来的分析结果准确度低的问题。
针对上述样本分析系统，预设分析模式集合包括：对血液样本涂片中的细胞进行图像拍摄和分析的血液分析模式，不同于血液分析模式的对体液样本涂片中的细胞进行图像拍摄和分析的体液分析模式，以及不同于血液分析模式和体液分析模式的对样本涂片的指定区域内的全部细胞进行图像拍摄和分析的全细胞分析模式中的至少一种分析模式，对应的控制装置106进一步配置用于在根据待测样本的样本信息，从预设分析模式集合中确定细胞图像分析装置的运行模式时：
根据待测样本的样本信息，从血液分析模式、体液分析模式和全细胞分析模式中的至少一种分析模式中确定细胞图像分析装置的运行模式，即控制装置106从血液分析模式、体液分析模式和全细胞分析模式中选取出与待测样本的样本信息相匹配的分析模式作为细胞图像分析装置的运行模式。
在本实施例中，样本信息可以包括样本类型信息和受试者信息，样本类型信息用于指示待测样本的类型，如待测样本为血液样本和体液样本中的任意一种，受试者信息则用于指向待测样本所属受试者。相对应的控制装置106可以根据样本类型信息或者受试者信息来确定细胞图像分析装置的运行模式，其确定过程包括如下至少一种方式：
如果样本信息中的样本类型信息为血液样本，则将血液分析模式设定为细胞图像分析装置的运行模式，这样在待测样本是一个血液样本时，可以将血液分析模式设定为细胞图像分析装置的运行模式。
如果样本信息中的样本类型信息为体液样本，则将体液分析模式设定为细胞图像分析装置的运行模式，这样在待测样本是一个体液样本时，可以将体液分析模式设定为细胞图像分析装置的运行模式。
根据样本信息中的受试者信息，从所述预设分析模式集合中确定与受试者信息对应的分析模式作为细胞图像分析装置的运行模式。其中与受试者信息对应的分析模式可以是在使用样本分析系统之前由用户介入提前设置，通过人机交互方式设置受试者信息分别对应的分析模式，例如与受试者信息对应的分析模式为全细胞分析模式，则可以从预设分析模式中确定全细胞分析模式为细胞图像分析装置的运行模式。
在本实施例中，受试者信息包括但不限于科室信息、年龄、性别、用药情况和治疗情况中的至少一种，通过人机交互方式根据受试者信息中的一种或多种信息设置对应的分析模式，例如科室信息能够指示待测样本所属科室，在人机交互设置分析模式时能够为至少一个科室设置对应的分析模式，如儿科对应的分析模式为全细胞分析模式，血液科对应的分析模式为血液WBC分析模式、血液RBC分析 模式和血液PLT分析模式；又例如年龄能够指示受试者是儿童、青少年、成年人和老年人，而不同年龄阶段的受试者的测试需求可能不同，在本实施例中可以为不同年龄阶段的受试者匹配对应的分析模式，这样控制装置能够根据当前的受试者信息中的年龄确定对应的分析模式为细胞图像分析装置的运行模式，下面以受试者信息指向受试者为预设关注对象，科室信息指示待测样本来自预设科室为例进行说明，对于受试者中的其他信息也可以设置对应的分析模式，本实施例不再一一说明。
如果受试者信息指向受试者为预设关注对象，预先设定预设关注对象对应的分析模式为全细胞分析模式，这样样本信息中的受试者信息指向的受试者为预设关注对象时，控制装置将全细胞分析模式设定为细胞图像分析装置的运行模式。如受试者为白血病患者而被定义为预设关注对象，则将全细胞分析模式设定为细胞图像分析装置的运行模式，以对待测样本中白细胞所在区域的全部细胞进行图像拍摄和分析。当然预设关注对象还可以是其他患者，对此本实施例不一一说明。此外，与预设关注对象对应的分析模式由用户提前设定，对此本实施例也不一一说明。
如果受试者信息中的科室信息指示待测样本来自预设科室，则从所述预设分析模式集合中确定与预设科室对应的分析模式为所述细胞图像分析装置的运行模式。若预先设定预设科室对应的分析模式为全细胞分析模式，受试者信息中的科室信息指示待测样本来自预设科室，则将全细胞分析模式设定为细胞图像分析装置的运行模式，如受试者信息中的科室指示待测样本来自新生儿科，则将全细胞分析模式设定为细胞图像分析装置的运行模式。应当说明的是，预设科室与对应的分析模式由用户根据试剂需求进行设定，对此本实施例不一一说明。
其中预设关注对象、预设科室、预设关注对象对应的分析模式和预设科室对应的分析模式可以是在使用样本分析系统之前由用户提前设置，以在使用样本分析系统之前允许用户介入为预设关注对象和预设科室设置匹配的分析模式，这样在获取到受试者信息之后可以根据受试者信息自动选择对应的分析模式，针对受试者信息的待测样本有针对性的进行处理，提高处理准确度。
在本实施例中，在全细胞分析模式下，细胞图像分析装置对样本涂片的拍摄过程如下：
确定样本涂片的拍摄区域，其中拍摄区域可以是一个固定区域，固定区域的位置可以预先设定或者是根据细胞图像分析装置中的低倍物镜(如上述第一物镜)拍摄的图像中确定出拍摄区域；拍摄区域还可以是一个不定区域，如拍摄区域可以通过人机交互方式确定，如由用户指定拍摄位置和拍摄尺寸(拍摄位置和拍摄尺寸限定出拍摄区域)，或者是由用户指定拍摄位置，根据该拍摄位置自动确定出一个拍摄区域，如以拍摄位置为中心确定出一个圆形区域或矩形区域。人机交互方式可以包括但不限定于通过显示界面进行人机交互、通过语音发送人机交互指令等。
在确定拍摄区域之后，通过细胞图像分析装置中的第一物镜和第二物镜中的高倍物镜(如100倍 物镜)对拍摄区域进行全区域扫描，得到拍摄区域在高倍物镜下的成像。其中全区域扫描表示对拍摄区域的每个位置都要进行扫描，而高倍物镜对拍摄区域进行全区域扫描时，因为高倍物镜的放大倍数较大使得高倍物镜需要分多次扫描才能完成全区域扫描，所以高倍物镜每扫描一次会得到本次扫描区域的图像，在完成最后一次扫描后将每次得到的图像按照扫描先后顺序拼接成拍摄区域在高倍物镜下的成像。
如图7所示为全细胞分析模式下的拍摄，首先确定出拍摄区域，然后在100倍物镜下对拍摄区域进行全区域扫描，在全区域扫描过程中会得到多张图像，在全区域扫描结束后多张图像按照扫描先后顺序拼接成图7中所示的图像。在实际医疗处理过程中，全细胞分析模式下可以确定一个或一个以上拍摄区域，对每个拍摄区域进行全区域扫描得到每个拍摄区域拼接的图像，如果需要将所有拍摄区域拼接成一个图像，也可以在拼接得到每个拍摄区域的图像之后进一步拼接得到所有拍摄区域对应的一个图像。
借由上述样本分析系统，通过控制装置106可以根据样本类型信息和受试者信息，从预设分析模式集合中的血液分析模式、体液分析模式和全细胞分析模式中选取出相匹配的分析模式作为细胞图像分析装置的运行模式，实现运行模式的自动确定并提高准确度。
在实际医疗检测分析中，待测样本的检测结果信息也会触发细胞图像分析装置采用不同的运行模式，例如待测样本的检测结果信息指示血液样本中的白细胞异常和指示血液样本中的红细胞异常时，细胞图像分析装置采用的运行模式会有所不同，基于此，本实施例的控制装置106进一步配置用于：根据待测样本的样本信息和检测结果信息，从预设分析模式集合中确定细胞图像分析装置的运行模式，使得细胞图像分析装置的运行模式与待测样本的样本信息和检测结果信息相匹配。
例如待测样本为血液样本且检测结果信息指示血液样本中的白细胞异常，则需要从预设分析模式集合中选取与血液样本中的白细胞匹配的分析模式为运行模式；如果检测结果信息指示体液样本中的血小板异常，则需要从预设分析模式集合中选取与体液样本中的血小板匹配的分析模式为运行模式，因此本实施例的血液分析模式和体液分析模式进一步包括与细胞类型相对应的分析模式，下面从血液分析模式和体液分析模式分别进行说明：
在本实施例中，血液分析模式进一步包括：对血液样本涂片中的白细胞进行图像拍摄和分析的血液WBC分析模式、对血液样本涂片中的红细胞进行图像拍摄和分析的血液RBC分析模式、对血液样本涂片中的血小板进行图像拍摄和分析的血液PLT分析模式中的至少一种模式，即血液分析模式包括：白细胞、红细胞和血小板中至少一种类型细胞对应的分析模式，若随着医疗技术的发展，在血液样本中发现其他对人类身体有影响的细胞时，还可以在血液分析模式中增加对应细胞的分析模式，以适应 医疗技术的发展需求。
控制装置106进一步配置用于在根据待测样本的样本信息和检测结果信息，从预设分析模式集合中确定细胞图像分析装置的运行模式时采用如下至少一种方式：
如果样本信息中的样本类型信息为血液样本，且检测结果信息包含表明待测样本中的白细胞异常的异常结果信息，则将血液WBC分析模式设定为细胞图像分析装置的运行模式，其中检测结果信息包含表明待测样本中的白细胞异常的异常结果信息说明待测样本中的白细胞异常，且待测样本是血液样本，此时控制装置106可以将血液WBC分析模式设定为细胞图像分析装置的运行模式。
如果样本信息中的样本类型信息为血液样本，且检测结果信息包含表明待测样本中的红细胞异常的异常结果信息，则将血液RBC分析模式设定为细胞图像分析装置的运行模式，同样的检测结果信息包含表明待测样本中的红细胞异常的异常结果信息说明待测样本中的红细胞异常，且待测样本是血液样本，此时控制装置106可以将血液RBC分析模式设定为细胞图像分析装置的运行模式。
如果样本信息中的样本类型信息为血液样本，且检测结果信息包含表明待测样本中的血小板异常的异常结果信息，则将血液PLT分析模式设定为细胞图像分析装置的运行模式，同样的检测结果信息包含表明待测样本中的血小板异常的异常结果信息说明待测样本中的血小板异常，且待测样本是血液样本，此时控制装置106可以将血液PLT分析模式设定为细胞图像分析装置的运行模式。
如果样本信息中的样本类型信息为血液样本，且检测结果信息表明待测样本中存在原始细胞，则将全细胞分析模式设定为细胞图像分析装置的运行模式，其中检测结果信息表明待测样本中存在原始细胞是指：待测样本本身就是一个异常样本，以患有白血病的病人为例，患有白血病的病人的待测样本中存在异常的白细胞——原始细胞，对于这种类型的待测样本，将全细胞分析模式设定为细胞图像分析装置的运行模式，全细胞分析模式的拍摄过程请参见上述说明，此处不再详述。
本实施例针对血液样本，控制装置106能够进一步结合血液样本的检测结果信息来细分血液样本的样本涂片对应的分析模式，以将细胞图像分析装置的运行模式确定为血液样本的检测结果信息匹配的分析模式，实现运行模式的进一步细化和自动确定，这样就可以针对血液样本中的不同异常指导细胞图像分析装置进行图像拍摄和分析，相对于现有针对血液样本的不同异常都采用统一的运行模式来说，使得细胞图像分析装置的处理效率和分析结果准确度进一步提高。例如血液样本的检测结果信息包含表明待测样本中的白细胞异常的异常结果信息，则说明待测样本中的白细胞异常，此时将血液样本的白细胞匹配的血液WBC分析模式设定为细胞图像分析装置的运行模式。下面结合附图对细胞图像分析装置在血液WBC分析模式、血液RBC分析模式和血液PLT分析模式下的拍摄过程进行说明：
血液WBC分析模式：
细胞图像分析装置通过第一物镜和第二物镜中的低倍物镜(如10倍物镜)搜索确定拍摄区域，在搜索确定拍摄区域时低倍物镜可以从样本涂片的头部向尾部移动搜索，以确定出拍摄区域，其中确定出的拍摄区域可以是但不限于是样本涂片的尾部和体部交界处(也称为体尾交界处)的单层细胞区域，确定出的拍摄区域可以是一个或一个以上区域；
通过细胞图像分析装置的低倍物镜扫描定位拍摄区域中的白细胞，在扫描定位白细胞过程中，低倍物镜可以以城垛型方式扫描定位，如低倍物镜从第一方向向第二方向移动扫描然后从第二方向向第一方向移动扫描，反复执行多次以对拍摄区域的各个位置进行扫描定位，其中第一方向向第二方向以及第二方向向第一方向可以是样本涂片的头部向尾部的垂直方向；通过细胞图像分析装置的第一物镜和第二物镜中的高倍物镜(如100倍物镜)对扫描定位到的白细胞进行拍摄。
如图8至图10所示，通过细胞图像分析装置中的10倍物镜从头部自动向尾部搜索确定出样本涂片的拍摄区域，如图8中的箭头指向方向示出从头部自动向尾部搜索；然后通过10倍物镜以图9所示城垛型方式对拍摄区域中的白细胞进行扫描定位；在扫描定位到白细胞之后，通过100倍物镜对扫描定位到的白细胞进行拍摄，如图10所示，在100倍物镜下视野图像清晰度提高，通过100倍物镜对扫描定位到的白细胞进行放大，然后由细胞图像分析装置中的相机进行拍摄，得到图10所示放大后白细胞的图像。
血液RBC分析模式：
细胞图像分析装置通过第一物镜和第二物镜中的低倍物镜(如10倍物镜)搜索确定拍摄区域，在搜索确定拍摄区域时低倍物镜可以从样本涂片的头部向尾部移动搜索，以确定出拍摄区域，其中确定出的拍摄区域可以是但不限于是样本涂片的尾部和体部交界处(简称体尾交界处)的单层细胞区域，确定出的拍摄区域可以是一个或一个以上区域；
通过细胞图像分析装置的第一物镜和第二物镜中的高倍物镜(如100倍物镜)对拍摄区域中的红细胞进行拍摄。
如图11所示，在10倍物镜下确定出拍摄区域(如11中方框所示中)，然后在100倍物镜下对该拍摄区域进行拍摄，或者在该拍摄区域中设定拍摄面积再在100倍物镜下对该拍摄面积覆盖的区域进行拍摄。在100倍物镜下拍摄时可能拍摄到多张图像，相邻图像之间可能存在重叠，将100倍物镜下的所有图像进行拼接得到图11所示拍摄区域的图像。
血液PLT分析模式：
细胞图像分析装置通过第一物镜和第二物镜中的低倍物镜(如10倍物镜)搜索确定拍摄区域，在搜索确定拍摄区域时低倍物镜可以从样本涂片的头部向尾部移动搜索，以确定出拍摄区域，其中确定 出的拍摄区域可以是但不限于是样本涂片的体尾交界处的单层细胞区域，确定出的拍摄区域可以是一个或一个以上区域；
通过细胞图像分析装置的第一物镜和第二物镜中的高倍物镜(如100倍物镜)对拍摄区域中的血小板进行拍摄。
如图12所示，在10倍物镜下确定出拍摄区域(如12中方框所示中)，然后在100倍物镜下对图12所示的拍摄区域进行拍摄，或者在该拍摄区域中设定拍摄面积再在100倍物镜下对该拍摄面积覆盖的区域进行拍摄。在100倍物镜下拍摄时可能拍摄到多张图像，相邻图像之间可能存在重叠，将100倍物镜下的所有图像进行拼接得到图12所示拍摄区域的图像。
细胞图像分析装置可参照上述血液WBC分析模式、血液RBC分析模式和血液PLT分析模式下的拍摄过程对样本涂片进行图像拍摄，这样细胞图像分析装置在确定运行模式之后可以采用与运行模式匹配的图像拍摄方式进行图像拍摄。并且从上述血液RBC分析模式和血液PLT分析模式的介绍可知，血液RBC分析模式和血液PLT分析模式的拍摄方式相同，因此血液RBC分析模式和血液PLT分析模式为同一种分析模式，即血液RBC分析模式和血液PLT分析模式下细胞图像分析装置的拍摄方式相同，在实际样本检测需求下，血液RBC分析模式和血液PLT分析模式下细胞图像分析装置的拍摄方式可以不同，本实施例不再对不同的拍摄方式进行说明。
对于体液样本来说，在本实施例中，体液分析模式进一步包括：对体液样本涂片中的白细胞进行图像拍摄和分析的体液WBC分析模式和对体液样本涂片中的红细胞进行图像拍摄和分析的体液RBC分析模式中的至少一种，即体液分析模式包括：白细胞和红细胞中至少一种类型细胞对应的分析模式，若随着医疗技术的发展，在体液样本中发现其他对人类身体有影响的细胞时，还可以在体液分析模式中增加对应细胞的分析模式，以适应医疗技术的发展需求。
控制装置106进一步配置用于在根据待测样本的样本信息和检测结果信息，从预设分析模式集合中确定细胞图像分析装置的运行模式时采用如下至少一种方式：
如果样本信息中的样本类型信息为体液样本，且检测结果信息包含表明待测样本中的白细胞异常的异常结果信息，则将体液WBC分析模式设定为细胞图像分析装置的运行模式，其中检测结果信息包含表明待测样本中的白细胞异常的异常结果信息说明待测样本中的白细胞异常，且待测样本是体液样本，此时控制装置106可以将体液WBC分析模式设定为细胞图像分析装置的运行模式。
如果样本信息中的样本类型信息为体液样本，且检测结果信息包含表明待测样本中的红细胞异常的异常结果信息，则将体液RBC分析模式设定为细胞图像分析装置的运行模式，同样的检测结果信息包含表明待测样本中的红细胞异常的异常结果信息说明待测样本中的红细胞异常，且待测样本是体液 样本，此时控制装置106可以将体液RBC分析模式设定为细胞图像分析装置的运行模式。
本实施例针对体液样本，控制装置106能够进一步结合体液样本的检测结果信息来细分体液样本的样本涂片对应的分析模式，以将细胞图像分析装置的运行模式确定为体液样本的检测结果信息匹配的分析模式，实现运行模式的进一步细化和自动确定。例如体液样本的检测结果信息包含表明待测样本中的白细胞异常的异常结果信息，则说明待测样本中的白细胞异常，此时将体液样本的白细胞匹配的体液WBC分析模式设定为细胞图像分析装置的运行模式。下面对细胞图像分析装置在体液WBC分析模式和体液RBC分析模式下的拍摄过程进行说明：
体液WBC分析模式：
确定样本涂片的拍摄区域，对于体液样本来说，在制备体液样本的样本涂片时需要在样本涂片中甩出一个特定形状的区域，因此体液样本的样本涂片在体液WBC分析模式下，体液样本的样本涂片的拍摄区域需要根据样本涂片中特定形状的区域，如在样本涂片中特定形状的区域内指定拍摄区域，该拍摄区域的拍摄位置和拍摄尺寸可通过人机交互方式确定，如通过显示界面进行人机交互由用户在样本涂片中特定形状的区域内指定拍摄位置，并基于拍摄位置向外延伸指定出拍摄尺寸，从而得到拍摄区域，或者上述拍摄区域可以覆盖在样本涂片中特定形状的区域，如拍摄区域包括样本涂片中特定形状的区域或者包括样本涂片中特定形状的区域的部分区域等；
通过细胞图像分析装置的第一物镜和第二物镜中的低倍物镜(如10倍物镜)扫描定位拍摄区域中的白细胞，在扫描定位白细胞过程中，低倍物镜可以以城垛型方式扫描定位，如低倍物镜从第一方向向第二方向移动扫描然后从第二方向向第一方向移动扫描，反复执行多次以对拍摄区域的各个位置进行扫描定位，其中第一方向向第二方向以及第二方向向第一方向可以是样本涂片的头部向尾部的垂直方向；通过细胞图像分析装置的第一物镜和第二物镜中的高倍物镜(如100倍物镜)对扫描定位到的白细胞进行拍摄。
如图13至图15所示，细胞图像分析装置获取用户在图13所示样本涂片上指定的拍摄区域，该拍摄区域位于样本涂片的特定形状的区域(如图13所示圆形区域)中，通过细胞图像分析装置的10倍物镜以图14所示城垛型方式扫描定位拍摄区域中的白细胞，然后通过100倍物镜对扫描定位到的白细胞进行放大，由细胞图像分析装置中的相机进行拍摄，得到图15所示放大后白细胞的图像。
体液RBC分析模式：
确定样本涂片的拍摄区域；通过细胞图像分析装置的第一物镜和第二物镜中的高倍物镜(如100倍物镜)对拍摄区域进行拍摄，其中体液RBC分析模式的拍摄方式请参见上述血液RBC分析模式。
细胞图像分析装置可参照上述体液WBC分析模式和体液RBC分析模式下的拍摄过程对样本涂片进 行图像拍摄，这样细胞图像分析装置在确定运行模式之后可以采用与运行模式匹配的图像拍摄方式进行图像拍摄。
在本实施例中，针对上述血液样本和体液样本，检测结果信息的异常结果信息包含如下信息的至少一种：待测样本的细胞检测参数对应的数值异常、待测样本中存在异常细胞、在设定间隔时间内从同一受试者获取的各个待测样本的同一细胞参数之间的差值超出预设范围。
其中，待测样本的细胞检测参数对应的数值异常主要表明一个细胞检测参数异常，如细胞检测参数对应的数值不满足对应的阈值(如大于阈值或不在阈值范围内)、细胞检测参数缺省(例如细胞检测参数为空或者细胞检测参数对应的数值为初始值)、细胞检测参数对应的数值直接表示是否存在异常(例如不需要通过阈值方式确定)等等都视为是细胞检测参数对应的数值异常。
以血液样本中的白细胞异常为例，血液样本对应的检测结果信息中与白细胞对应的信息如表1所示，
表1血液样本对应的检测结果信息中与白细胞对应的信息
异常 备注
白细胞散点图异常  
有核红细胞散点图异常  
抗溶红细胞？  
原始细胞？  
异常淋巴细胞/原始细胞？  
未成熟粒细胞？  
异型淋巴细胞？  
有核红细胞？  
核左移？  
脂质颗粒？  
感染红细胞？  
出现有核红细胞 通过参数对应的数值是否满足阈值判断
嗜碱性粒细胞增多 通过参数对应的数值是否满足阈值判断
嗜酸性粒细胞增多 通过参数对应的数值是否满足阈值判断
单核细胞增多 通过参数对应的数值是否满足阈值判断
淋巴细胞增多 通过参数对应的数值是否满足阈值判断
淋巴细胞减少 通过参数对应的数值是否满足阈值判断
嗜中性粒细胞增多 通过参数对应的数值是否满足阈值判断
嗜中性粒细胞减少 通过参数对应的数值是否满足阈值判断
白细胞增多 通过参数对应的数值是否满足阈值判断
白细胞减少 通过参数对应的数值是否满足阈值判断
上述表1所示是针对白细胞存在的异常结果信息，从上述表1可知参数“白细胞散点图异常”至“感染红细胞？”都是通过细胞检测参数对应的数值直接表示是否存在异常，而从“出现有核红细胞”至“白细胞减少”都是通过细胞检测参数对应的数值是否满足对应的阈值来判断是否存在异常。当然对于上述表1所示白细胞来说，若有一项输出为空或者为默认值，则认为细胞检测参数缺省，此时会认为缺省的细胞检测参数存在异常。
血液样本对应的检测结果信息中与红细胞对应的信息如表2所示。
表2血液样本对应的检测结果信息中与红细胞对应的信息
异常 备注
网织红细胞散点图异常  
混浊/HGB干扰？  
红细胞凝集？  
碎片？  
红细胞双峰  
红细胞直方图异常  
红细胞大小不均 通过参数对应的数值是否满足阈值判断
低色素性 通过参数对应的数值是否满足阈值判断
缺铁性？  
大细胞性红细胞 通过参数对应的数值是否满足阈值判断
小细胞性红细胞 通过参数对应的数值是否满足阈值判断
贫血 通过参数对应的数值是否满足阈值判断
红细胞增多 通过参数对应的数值是否满足阈值判断
网织红细胞增多 通过参数对应的数值是否满足阈值判断
上述表2所示是针对红细胞存在的异常结果信息，从上述表1可知“网织红细胞散点图异常”至“红细胞直方图异常”以及“缺铁性？”都是通过细胞检测参数对应的数值直接表示是否存在异常，剩余则是通过细胞检测参数对应的数值是否满足对应的阈值来判断是否存在异常。当然对于上述表2所示红细胞来说，若有一项输出为空或者为默认值，则认为细胞检测参数缺省，此时会认为缺省的细胞检测参数存在异常，例如若没有输出网织红细胞散点图异常，则直接认为存在该异常。
同样的，血液样本对应的检测结果信息中与血小板对应的信息如表3所示，示出血小板中存在的异常情况。
表3血液样本对应的检测结果信息中与血小板对应的信息
参数 备注
血小板聚集  
血小板散点图异常  
血小板直方图异常  
血小板增多 通过参数对应的数值是否满足阈值判断
血小板减少 通过参数对应的数值是否满足阈值判断
大血小板 通过参数对应的数值是否满足阈值判断
小血小板 通过参数对应的数值是否满足阈值判断
上述表3所示是针对血小板存在的异常结果信息，从上述表3可知“血小板聚集”至“血小板直方图异常”都是通过细胞检测参数对应的数值直接表示是否存在异常，剩余则是通过细胞检测参数对应的数值是否满足对应的阈值来判断是否存在异常。当然对于上述表3所示血小板来说，若有一项输出为空或者为默认值，则认为细胞检测参数缺省，此时会认为缺省的细胞检测参数存在异常，例如若没有血小板聚集，则直接认为存在该异常。
上述待测样本中存在异常细胞表明待测样本本身就是一个异常样本，该异常样本中存在原始细胞，以患有白血病的病人为例，患有白血病的病人的待测样本中存在异常的白细胞，如上述原始细胞，对于这种类型的待测样本直接判断为异常。
对于同一受试者(即患者)来说，其同一类型的待测样本在一定时间内不会出现大幅度变化，因此若在设定间隔时间内从同一受试者获取的各个待测样本的同一细胞参数之间的差值超出预设范围，说明该受试者的待测样本的同一细胞参数在设定间隔时间内出现大幅度变化，此时也会视为出现异常。
在这里需要说明的一点是：如果在设定间隔时间内细胞参数的数值在正常范围内，但是其差值超出预设范围，同样判断为待测样本出现异常的异常结果信息，例如对于红细胞来说，同一受试者在三天内测试到的红细胞的数值分别为3.5*10 12/L和5.9*10 12/L，虽然都在正常范围，但差异过大，因此正常生理过程三天内参数不会发生如此大的变化，此时则认为存在异常，在本实施例是以红细胞三天内的数值变化为例，在实际应用中设定间隔时间和预设范围可以根据待测样本的样本类型信息和待测样本中的细胞参数确定，对此本实施例不一一说明并对设定间隔时间和预设范围的取值进行限定。
控制装置106获取到的检测结果信息表明上述至少一种异常时，控制装置106则会根据待测样本的样本信息和检测结果信息，从预设分析模式集合中确定细胞图像分析装置的运行模式，其中控制装置106可以直接从血液细胞分析仪中获取到是否存在异常的结果，即由血液细胞分析仪来判断是否存在异常，将是否存在异常的结果携带在检测结果信息中，或者由控制装置106来判断是否存在异常。
此外在这里需要说明的一点是：若控制装置106从上述分析模式中选取不到与待测样本的样本信息相匹配的分析模式，控制装置106可以发出提示信息，该提示信息用于指示用户选择或者输入细胞图像分析装置的运行模式，或者控制装置106发出的提示信息中包括待选分析模式，该待选分析模式 不同于预设分析模式集合中的任一分析模式，该待选分析模式可以提供给用户，如通过控制装置106输出该待选分析模式以供用户进行运行模式的选择。其中控制装置106输出待选分析模式的方式包括但不限于：显示输出、通过语音输出和通过文字输出中的至少一种输出方式。
在本实施例中，细胞图像分析装置能够在运行模式下对样本涂片进行图像拍摄和定位，其中细胞图像分析装置的运行模式包括一种或一种以上。若细胞图像分析装置的运行模式为一种，则在该运行模式下完成图像拍摄和分析之后等待对下一个样本涂片进行图像拍摄和分析；若细胞图像分析装置的运行模式包括一种以上，如两种或三种等等，则细胞图像分析装置可以依次在多种运行模式下对同一个样本涂片进行图像拍摄和分析，例如细胞图像分析装置的运行模式包括血液WBC分析模式和血液RBC分析模式，则细胞图像分析装置分别采用上述血液WBC分析模式和血液RBC分析模式的拍摄过程对同一个样本涂片进行图像拍摄，在拍摄完成后对每个细胞图像进行分析，或者在采用上述血液WBC分析模式和血液RBC分析模式的拍摄过程对同一个样本涂片进行依次拍摄过程中，每得到一张图像可以立即进行分析，在该分析过程中可以还可以在剩余的运行模式下继续对样本涂片进行图像拍摄，实现分析和图像拍摄的同时进行。
当细胞图像分析装置的运行模式包括一种以上时，细胞图像分析装置的运行模式可以是同时确定或者是依次分时确定。其中同时确定是指根据检测结果信息能够同时确定一种以上的运行模式，如一份血液样本中，血液细胞分析仪输出的检测结果中表明该血液样本中存在白细胞和红细胞异常，则控制装置则同时将血液WBC分析模式和血液RBC分析模式确定为运行模式。在本实施例中控制装置106依次分时确定细胞图像分析装置的多种运行模式的一种可选方式如下：
控制装置106还配置用于：如果细胞图像分析装置在运行模式下识别到样本涂片中存在其他异常，则从预设分析模式集合中选择与其他异常对应的分析模式作为追加运行模式，并将细胞图像分析装置在追加运行模式下对样本涂片进行图像拍摄和分析，从而实现在对待测样本进行分析的过程中自动追加细胞图像分析装置的运行模式，即在运行模式下对样本进行分析过程中能够实时发现样本涂片中的异常并追加相应的运行模式，进一步指导细胞图像分析装置采用与异常匹配的运行模式进行图像拍摄和分析，进一步提高处理结果的准确度。其中其他异常与运行模式下对应的异常不同，如运行模式下对应的异常为白细胞异常，其他异常则可能是在运行模式下识别到样本涂片中存在的除白细胞异常之外的异常，如红细胞异常和/或血小板异常等。
对于细胞图像分析装置来说，其在运行模式下识别到待测样本中存在其他异常的方式可参照目前细胞图像分析装置的分析方式，对此本实施例不再说明。但是细胞图像分析装置识别到的其他异常是针对同一样本类型下的异常，如对于血液样本来说，细胞图像分析装置在血液WBC分析模式下识别到 待测样本中存在红细胞异常，则从预设分析模式集合中选择血液RBC分析模式作为追加运行模式。
在运行模式和追加运行模式下，控制装置106对细胞图像分析装置的控制过程包括：控制装置106还用于：使细胞图像分析装置在运行模式下完成对样本涂片的图像拍摄和分析之后调用追加运行模式对样本涂片进行图像拍摄和分析，即使细胞图像分析装置依次调用运行模式和追加运行模式对样本涂片进行图像拍摄和分析。
若细胞图像分析装置在追加运行模式下识别到样本涂片中仍存在其他异常，控制装置106也会进一步从预设分析模式集合中选择与其他异常对应的分析模式作为另一个追加运行模式，使细胞图像分析装置在追加运行模式下完成对样本涂片的图像拍摄和分析之后调用另一个追加运行模式对由涂片制备装置制备的样本涂片进行图像拍摄和分析。若细胞图像分析装置识别到的异常在预设分析模式集合中无法匹配到对应的分析模式，控制装置106可以发出提示信息，该提示信息用于指示用户选择或者输入细胞图像分析装置的运行模式，或者控制装置106发出的提示信息中包括待选分析模式，该待选分析模式不同于预设分析模式集合中的任一分析模式，该待选分析模式可以提供给用户，如通过控制装置106输出该待选分析模式以供用户进行运行模式的选择。其中控制装置106输出待选分析模式的方式包括但不限于：显示输出、通过语音输出和通过文字输出中的至少一种输出方式。
从上述样本分析系统的说明可知，控制装置106能够在细胞图像分析装置分析识别到其他异常时，为细胞图像分析装置追加运行模式，并使细胞图像分析装置依次调用运行模式和追加运行模式对样本涂片进行图像拍摄和分析，实现追加运行模式的自动确定和调用，使得控制装置能够在细胞图像分析装置进行分析过程中能够实时根据样本涂片中的异常追加相应的运行模式，进一步指导细胞图像分析装置采用与异常匹配的运行模式进行图像拍摄和分析，进一步提高处理结果的准确度。
图16示出了本发明实施例提供的样本分析系统的另一种可选的结构，其中图16所示样本分析系统200可以包括：血液细胞分析仪201、涂片制备装置202、细胞图像分析装置203、运送装置204和控制装置205。
血液分析以201，用于对待测样本进行检测以获取检测结果信息。
涂片制备装置202，用于制备待测样本的样本涂片。
细胞图像分析装置203，用于对由涂片制备装置制备的样本涂片进行图像拍摄和分析。
运送装置204，包括第一运送轨道2041和第二运送轨道2042，第一运送轨道用于将待测样本从血液细胞分析仪运送到涂片制备装置，第二运送轨道用于将样本涂片从涂片制备装置运送到细胞图像分析装置。
控制装置205，与血液细胞分析仪201、涂片制备装置202、细胞图像分析装置203和运送装置204通信连接，并且配置用于：
从血液细胞分析仪获取待测样本的检测结果信息，当检测结果信息满足预定条件时，控制第一运送轨道将待测样本运送至涂片制备装置，以便涂片制备装置制备待测样本的样本涂片；控制第二运送轨道将样本涂片从涂片制备装置运送到细胞图像分析装置；根据待测样本的样本信息和/或检测结果信息，从预设分析模式集合中确定细胞图像分析装置的运行模式；控制细胞图像分析装置在运行模式下对样本涂片进行图像拍摄和分析。
相对于上述图2所示的样本分析系统100来说，图16所示的样本分析系统200针对的是血液样本这一类型样本，控制装置205根据待测样本的样本信息和待测样本的检测结果信息中的至少一种确定细胞图像分析装置203的运行模式，由于图16所示的样本分析系统200针对的是血液样本，所以控制装置根据待测样本的样本信息确定细胞图像分析装置203的运行模式时就不需要根据样本信息中的样本类型信息确定，且涂片制备装置202可以仅包括用于对血液样本进行涂片制备的第一制备装置。控制装置205可以从上述血液细胞分析仪201、涂片制备装置202和细胞图像分析装置203中的至少一个装置中获取样本信息，具体请参见上一系统实施例中的相关说明。
在本实施例中，血液细胞分析仪201、细胞图像分析装置203和运送装置204的说明可参见上述图1所示样本分析系统100中的相关说明，此处不再详述。进一步的图16所示样本分析系统200中的控制装置205与上述控制装置106的不同之处在于：控制装置205根据待测样本的样本信息和待测样本的检测结果信息中的至少一种，从预设分析模式集合中确定细胞图像分析装置的运行模式，即控制装置205确定的细胞图像分析装置的运行模式与待测样本的样本信息和待测样本的检测结果信息中的至少一种对应。其中检测结果信息满足预定条件的说明(如预定条件包括：检测结果信息包含表明待测样本出现异常的异常结果信息)、控制装置205确定运行模式的时机以及控制装置205控制细胞图像分析装置在该运行模式下对样本涂片进行图像拍摄和分析的说明请参见上述实施例中的相关说明，对此本实施例不再阐述。
在本发明实施例中，样本分析系统包括：血液细胞分析仪、涂片制备装置、细胞图像分析装置、运送装置和控制装置，控制装置配置用于从血液细胞分析仪获取待测样本的检测结果信息，当检测结果信息满足预定条件时，控制运送装置中的第一运送轨道将待测样本运送至涂片制备装置，以便涂片制备装置制备待测样本的样本涂片，控制运送装置的第二运送轨道将样本涂片从涂片制备装置运送到细胞图像分析装置；并根据待测样本的样本信息和/或检测结果信息，从预设分析模式集合中确定细胞图像分析装置的运行模式，控制细胞图像分析装置在运行模式下对样本涂片进行图像拍摄和分析，由 此实现自动确定细胞图像分析装置的运行模式，这样在每获取到一个待测样本，都可以通过样本分析系统中的控制装置自动确定细胞图像分析装置针对该样本涂片的运行模式，使得细胞图像分析装置能够根据样本信息指导细胞图像分析装置进行图像拍摄和分析，即针对不同的样本涂片根据该样本涂片匹配的运行模式指导细胞图像分析装置进行图像拍摄和分析，提高细胞图像分析装置的处理效率和处理结果的准确度，克服目前在人工指定的运行模式下对样本涂片进行相同的图像拍摄和分析带来的处理效率低的问题，同时也克服了目前设置统一的样本涂片分析模式所带来的分析结果准确度低的问题。
针对图16所示的样本分析系统，预设分析模式集合包括：对血液样本涂片中的白细胞进行图像拍摄和分析的血液WBC分析模式，对血液样本涂片中的红细胞进行图像拍摄和分析的血液RBC分析模式，对血液样本涂片中的血小板进行图像拍摄和分析的血液PLT分析模式，以及对血液样本涂片的指定区域内的全部细胞进行图像拍摄和分析的全细胞分析模式中的至少一种分析模式，对应的控制装置205进一步配置用于在根据待测样本的检测结果信息，从预设分析模式集合中确定细胞图像分析装置的运行模式时：
根据待测样本的检测结果信息，从血液WBC分析模式、血液RBC分析模式、血液PLT分析模式和全细胞分析模式中的至少一种分析模式中确定细胞图像分析装置的运行模式，以从这些分析模式中选取出与检测结果信息匹配的分析模式作为细胞图像分析装置的运行模式。例如待测样本的检测结果信息与血液样本中的白细胞相关(如白细胞异常)，控制装置将血液WBC分析模式作为细胞图像分析装置的运行模式，细胞图像分析装置则可以基于上述血液WBC分析模式下的拍摄方式对样本涂片进行图像拍摄。
在这需要说明的一点是：从上述血液RBC分析模式和血液PLT分析模式的拍摄方式可知，血液RBC分析模式和血液PLT分析模式的拍摄方式相同，因此本实施例中血液RBC分析模式和血液PLT分析模式可以为同一种分析模式，即血液RBC分析模式和血液PLT分析模式的拍摄方式相同，在实际样本检测过程中，血液RBC分析模式和血液PLT分析模式的拍摄方式也可以不同。
在本实施例中，控制装置205从血液WBC分析模式、血液RBC分析模式、血液PLT分析模式和全细胞分析模式确定细胞图像分析装置的运行模式的一种可选方式如下：
控制装置205进一步配置用于在根据待测样本的检测结果信息，从预设分析模式集合中确定细胞图像分析装置的运行模式时采用如下至少一种方式：
如果检测结果信息包含表明待测样本中的白细胞异常的异常结果信息，则将血液WBC分析模式设定为细胞图像分析装置的运行模式。
如果检测结果信息包含表明待测样本中的红细胞异常的异常结果信息，则将血液RBC分析模式设 定为细胞图像分析装置的运行模式。
如果检测结果信息包含表明待测样本中的血小板异常的异常结果信息，则将血液PLT分析模式设定为细胞图像分析装置的运行模式。
如果检测结果信息表明待测样本中存在原始细胞，则将全细胞分析模式设定为细胞图像分析装置的运行模式。
其中，检测结果信息的异常结果信息包括如下信息中的至少一种：待测样本的细胞检测参数对应的数值异常、待测样本中存在异常细胞、在设定间隔时间内从同一受试者的各个待测样本的同一细胞参数之间的差值超出预设范围。
对于检测结果信息的异常结果信息的说明，控制装置205从血液WBC分析模式、血液RBC分析模式、血液PLT分析模式和全细胞分析模式确定细胞图像分析装置的运行模式的说明，以及血液WBC分析模式、血液RBC分析模式、血液PLT分析模式和全细胞分析模式下的拍摄方式都请参见上一实施例，对此本实施例不再阐述。
在本实施例中，控制装置205在确定细胞图像分析装置的运行模式根据的样本信息包括受试者信息，相对应的控制装置205进一步配置用于在根据待测样本的检测结果信息，从预设分析模式集合中确定细胞图像分析装置的运行模式时采用如下至少一种方式：
根据受试者信息，从预设分析模式集合中确定与受试者信息对应的分析模式作为细胞图像分析装置的运行模式，例如与受试者信息对应的分析模式为全细胞分析模式，则可以从预设分析模式中确定全细胞分析模式为细胞图像分析装置的运行模式；若与受试者信息对应的分析模式为血液WBC分析模式、血液RBC分析模式和血液PLT分析模式中的至少一种分析模式，则血液WBC分析模式、血液RBC分析模式和血液PLT分析模式中与受试者信息对应的分析模式作为细胞图像分析装置的运行模式。
在本实施例中，受试者信息包括但不限于科室信息、年龄、性别、用药情况和治疗情况中的至少一种，通过人机交互方式根据受试者信息中的一种或多种信息设置对应的分析模式，例如科室信息能够指示待测样本所属科室，在人机交互设置分析模式时能够为至少一个科室设置对应的分析模式，如儿科对应的分析模式为全细胞分析模式，血液科对应的分析模式为血液WBC分析模式、血液RBC分析模式和血液PLT分析模式；又例如用药情况和治疗情况能够指示受试者的患病程度，如果受试者的患病程度较重，则将全细胞分析模式作为受试者对应的分析模式，如果受试者的患病程度较轻，则将血液WBC分析模式、血液RBC分析模式和血液PLT分析模式中的一种分析模式作为受试者对应的分析模式。
下面以受试者信息指向受试者为预设关注对象，科室信息指示待测样本来自预设科室为例进行说 明，对于受试者中的其他信息也可以设置对应的分析模式，本实施例不再一一说明。
如果受试者信息指向的受试者为预设关注对象，从预设分析模式集合中确定与预设关注对象对应的分析模式为细胞图像分析装置的运行模式。应当说明的是，与预设关注对象对应的分析模式是由用户根据实际需要进行设定的；例如，预设关注对象对应的分析模式为全细胞分析模式，如果所述受试者信息指向的受试者为预设关注对象，则从预设分析模式集合中确定全细胞分析模式设定为细胞图像分析装置的运行模式；再如，预设关注对象对应的分析模式为血液WBC分析模式、血液RBC分析模式、血液PLT分析模式，则从预设分析模式集合中同时确定血液WBC分析模式、血液RBC分析模式、血液PLT分析模式为细胞图像分析装置的运行模式。
如果受试者信息中的科室信息指示待测样本来自预设科室，从预设分析模式集合中确定与预设科室对应的分析模式为细胞图像分析装置的运行模式。应当说明的是，与预设科室对应的分析模式是由用户根据实际需要进行设定的；例如，与预设科室对应的分析模式为全细胞分析模式，如果受试者信息中的科室信息指示待测样本来自预设科室，则从预设分析模式集合中确定全细胞分析模式设定为细胞图像分析装置的运行模式；再如，预设科室对应的分析模式为血液WBC分析模式、血液RBC分析模式、血液PLT分析模式，则从预设分析模式集合中同时确定血液WBC分析模式、血液RBC分析模式、血液PLT分析模式为细胞图像分析装置的运行模式。
对于上述根据样本信息确定细胞图像分析装置的运行模式的详细说明请参照上述系统实施例中的相关说明，对此本实施例不再阐述。
在本实施例中，控制装置205还能够同时根据待测样本的样本信息和检测结果信息，从预设分析模式集合中确定细胞图像分析装置的运行模式，如一种方式可以是：如果样本信息与预设分析模式集合中的第一分析模式对应，且检测结果信息与预设分析模式集合中不同于第一分析模式的第二分析模式对应，则将第一分析模式和第二分析模式都设定为细胞图像分析装置的运行模式。其中第一分析模式可以是血液WBC分析模式、血液RBC分析模式、血液PLT分析模式和全细胞分析模式中与当前的样本信息对应的分析模式，第二分析模式可以是血液WBC分析模式、血液RBC分析模式、血液PLT分析模式和全细胞分析模式中与当前的检测结果信息对应的分析模式。例如样本信息对应的分析模式是血液WBC分析模式，检测结果信息对应的分析模式是血液RBC分析模式，则控制装置能够同时将血液WBC分析模式和血液RBC分析模式确定为细胞图像分析装置的运行模式。
在本实施例中，细胞图像分析装置204在对血液样本的样本涂片进行图像拍摄和分析时，细胞图像分析装置的运行模式同样可以包括一种或一种以上。
若细胞图像分析装置的运行模式为一种，则在该运行模式下完成图像拍摄和分析之后等待对下一 个样本涂片进行图像拍摄和分析；若细胞图像分析装置的运行模式包括一种以上，如两种或三种等等，则细胞图像分析装置可以依次在多种运行模式下对同一个样本涂片进行图像拍摄和分析，例如细胞图像分析装置的运行模式包括血液WBC分析模式和血液RBC分析模式，则细胞图像分析装置分别采用上述血液WBC分析模式和血液RBC分析模式的拍摄过程对同一个样本涂片进行图像拍摄，在拍摄完成后对每个细胞图像进行分析，或者在采用上述血液WBC分析模式和血液RBC分析模式的拍摄过程对同一个样本涂片进行依次拍摄过程中，每得到一张图像可以立即进行分析，在该分析过程中可以还可以在剩余的运行模式下继续对样本涂片进行图像拍摄，实现分析和图像拍摄的同时进行。
当细胞图像分析装置的运行模式包括一种以上时，细胞图像分析装置的运行模式可以是同时确定或者是依次分时确定，在本实施例中控制装置205依次分时确定细胞图像分析装置的多种运行模式的一种可选方式如下：
控制装置205还配置用于：如果细胞图像分析装置在运行模式下识别到样本涂片中存在其他异常，则从预设分析模式集合中选择与其他异常对应的分析模式作为追加运行模式，并使细胞图像分析装置在追加运行模式下对样本涂片进行图像拍摄和分析，从而实现在对样本涂片进行分析的过程中自动追加细胞图像分析装置的运行模式。其中其他异常与运行模式下对应的异常不同，如运行模式下对应的异常为红细胞异常，其他异常则可能是在运行模式下识别到样本涂片中存在的除红细胞异常之外的异常，如白细胞异常和/或血小板异常等。
相对应的控制装置205还用于：使细胞图像分析装置在运行模式下完成样本涂片的图像拍摄和分析之后调用追加运行模式对样本涂片进行图像拍摄和分析，即使细胞图像分析装置依次调用运行模式和追加运行模式对样本涂片进行图像拍摄和分析。
若细胞图像分析装置在追加运行模式下识别到样本涂片中仍存在其他异常，控制装置205也会进一步从预设分析模式集合中选择与其他异常对应的分析模式作为另一个追加运行模式，使细胞图像分析装置在追加运行模式下完成对样本涂片的图像拍摄和分析之后调用另一个追加运行模式对样本涂片进行图像拍摄和分析。若细胞图像分析装置识别到的异常在预设分析模式集合中无法匹配到对应的分析模式，控制装置205可以发出提示信息，该提示信息用于指示用户选择或者输入细胞图像分析装置的运行模式，或者控制装置205发出的提示信息中包括待选分析模式，该待选分析模式不同于预设分析模式集合中的任一分析模式，该待选分析模式可以提供给用户，如通过控制装置205输出该待选分析模式以供用户进行运行模式的选择。其中控制装置205输出待选分析模式的方式包括但不限于：显示输出、通过语音输出和通过文字输出中的至少一种输出方式。
从上述样本分析系统的说明可知，控制装置205能够在细胞图像分析装置分析识别到其他异常时， 为细胞图像分析装置追加运行模式，并使细胞图像分析装置依次调用运行模式和追加运行模式对样本涂片进行图像拍摄和分析，实现追加运行模式的自动确定和调用，使得控制装置能够在细胞图像分析装置进行分析过程中能够实时根据样本涂片中的异常追加相应的运行模式，进一步指导细胞图像分析装置采用与异常匹配的运行模式进行图像拍摄和分析，进一步提高处理结果的准确度。
相对于上述图1所示样本分析系统100来说，图16所示的样本分析系统200的另一个不同之处是：
控制装置205还用于：接收模式设定指令，模式设定指令包括预设分析模式集合中各个分析模式与检测结果信息的对应关系；其中模式设定指令可以是由控制装置205生成或者控制装置205接收从独立于样本分析系统之外的一个终端发送的模式设定指令，该模式设定指令中可以携带预设分析模式结合中各个分析模式与检测结果信息的对应关系，以通过该对应关系指示检测结果信息采用哪种分析模式，又或者模式设定指令用于指示对预设分析模式集合中各个分析模式与检测结果信息的对应关系的进行设置，但是该设置过程可以在控制装置205接收到模式设定指令后，由用户通过控制装置205设置两者的对应关系，用户通过控制装置205设置两者的对应关系时可通过人机交互方式设置，如控制装置205包括一显示屏，在该显示屏中显示检测结果信息和预设分析模式集合中的各个分析模式，然后由用户对检测结果信息和各个分析模式进行选择，从而得到预设分析模式集合中各个分析模式与检测结果信息的对应关系。
而上述模式设定指令的生成方式也可以是通过人机交互方式生成，如通过在显示屏上对特定控件(如用于设置预设分析模式集合中各个分析模式与检测结果信息的对应关系的控件)的操作来生成模式设定指令，或者是在接收到包含特定词语的语音后生成模式设定指令，如接收到但不限于“设置预设分析模式集合中各个分析模式与检测结果信息的对应关系”的语音后生成模式设定指令。
控制装置205响应于模式设定指令，根据对应关系建立模式设定规则；根据模式设定规则和待测样本的检测结果信息，从预设分析模式集合中确定细胞图像分析装置的运行模式。
其中，根据对应关系建立的模式设定规则能够指示出检测结果信息对应的分析模式，那么在获取到当前待测样本的检测结果信息之后，控制装置205可以从模式设定规则中确定与当前待测样本的检测结果信息匹配(即相同)的检测结果信息，然后将匹配的检测结果信息对应的分析模式作为细胞图像分析装置的运行模式，虽然控制装置205需要提前建立模式设定规则，但是该模式设定规则能够基于当前医疗需求建立分析模式与检测结果信息的对应关系，那么在设定模式设定规则之后，能够准确地确定当前待测样本的检测结果信息匹配的分析模式为细胞图像分析装置的运行模式，提高准确度。
图17示出了本发明实施例提供的样本分析系统的再一种可选的结构，其中图17所示样本分析系 统300，包括：血液细胞分析仪301、涂片制备装置302、细胞图像分析装置303、运送装置304和控制装置305。
血液细胞分析仪301，用于对待测样本进行检测以获取检测结果信息。
涂片制备装置302，用于制备待测样本的涂片。
细胞图像分析装置303，用于对由涂片制备装置制备的样本涂片进行图像拍摄和分析。
运送装置304，包括第一运送轨道3041和第二运送轨道3042，第一运送轨道3041用于将待测样本从血液细胞分析仪运送到涂片制备装置，第二运送轨道3042用于将样本涂片从涂片制备装置运送到细胞图像分析装置。
控制装置305，与血液细胞分析仪301、涂片制备装置302、细胞图像分析装置303和运送装置304通信连接，并且配置用于：
响应于用户根据检测结果信息输入的相应的复检指令，显示模式指定界面；接收模式选择指令，模式选择指令用于指示用户从模式指定界面中选择出细胞图像分析装置的运行模式；响应于模式选择指令，控制第一运送轨道将待测样本运送至涂片制备装置，以便涂片制备装置制备待测样本的样本涂片；控制第二运送轨道将样本涂片从涂片制备装置运送到细胞图像分析装置；控制细胞图像分析装置调用所选择的运送模式对样本涂片进行图像拍摄和分析。
相对于上述图2所示的样本分析系统100来说，图17所示的样本分析系统300也可以同时针对血液样本和体液样本这两种类型样本，但是图17所示的样本分析系统300与上述图2所示的样本分析系统100来说，其不同之处是控制装置305针对的是对血液样本和体液样本中至少一种类型样本的检测结果信息的复检时细胞图像分析装置的运行模式的确定，而在针对血液样本和体液样本中至少一种类型样本的检测结果信息的复检时，用户是能够获知当前复检的待测样本的样本信息的，因此图17所示的样本分析系统300可以不需要上述样本信息获取装置105，当然图17所示的样本分析系统300也可以包括上述样本信息获取装置105，由上述样本信息获取装置105向控制装置305提供待测样本的样本信息。
在本实施例中，用户根据检测结果信息输入的相应的复检指令是在用户查看检测结果信息时，若用户认为需要进行复检则会通过用户端的终端发出复检指令，例如通过对用户端的终端上的复检控件操作来发出复检指令，当然也可以通过用户的语音输入和手势输入等来发出复检指令。
控制装置305在接收到复检指令后，响应该复检指令以显示模式指定界面，其中模式指定界面的显示方式可以是在控制装置305的显示屏上显示，或者通过控制装置305输出到其他设备中显示，如通过控制装置305输出到一个投影仪中，通过投影仪投影输出模式指定界面。
其中模式指定界面显示的模式包括：对血液样本涂片中的细胞进行图像拍摄和分析的血液分析模式、不同于血液分析模式的对体液样本涂片中的细胞进行图像拍摄和分析的体液分析模式、以及不同于血液分析模式和体液分析模式的对样本涂片的指定区域内的全部细胞进行图像拍摄和分析的全细胞分析模式中的至少一种分析模式，以使得用户能够在这些分析模式中选择出细胞图像分析装置的运行模式。对于模式指定界面显示模式的方式可参见图19所示，当然还可以采用其他方式显示，对此本实施例不再一一说明。
控制装置305在监测到用户选择出细胞图像分析装置的运行模式之后，生成一个模式选择指令，该模式选择指令的作用是指示用户选择出细胞图像分析装置的运行模式以及指示细胞图像分析装置开始在所选择的运行模式下对样本涂片进行图像拍摄和分析，细胞图像分析装置对样本涂片的拍摄方式请参见上述实施例中的说明。
通过上述图17所示的样本分析系统，在制备样本涂片之前样本分析系统可以允许用户介入，样本分析系统通过人机交互方式来决定是否进行样本涂片的制备，例如当待测样本经过血液细胞分析仪得到的检测结果信息显示结果正常，此时待测样本无需进行样本涂片的制备，但是医生还是可以根据该待测样本的检测结果信息来决定可以进行样本涂片的制备，此时通过样本分析系统可以控制涂片制备装置进行样本涂片的制备，为复检带来便利性。
在本实施例中，血液分析模式进一步包括：对血液样本涂片中的白细胞进行图像拍摄和分析的血液WBC分析模式、对血液样本涂片中的红细胞进行图像拍摄和分析的血液RBC分析模式、对血液样本涂片中的血小板进行图像拍摄和分析的血液PLT分析模式中的至少一种，这样控制装置305在获知当前待测样本为血液样本时可以进一步在模式指定界面上显示血液WBC分析模式、血液RBC分析模式和血液PLT分析模式中的至少一种，如图18所示，在模式指定界面上显示血液WBC分析模式、血液RBC分析模式和血液PLT分析模式，实现血液样本对应的运行模式的进一步细化，这样在进行复检时可以针对血液样本中的不同异常由用户选择不同的分析模式，指导细胞图像分析装置针对血液样本的不同异常进行图像拍摄和分析，相对于现有针对血液样本的不同异常都采用血液分析模式这一运行模式来说，进一步提高细胞图像分析装置的处理效率和准确度。
体液分析模式进一步包括：对体液样本涂片中的白细胞进行图像拍摄和分析的体液WBC分析模式和对体液样本涂片中的红细胞进行图像拍摄和分析的体液RBC分析模式中的至少一种，同样的控制装置305在获知当前待测样本为体液样本时可以进一步在模式指定界面上显示体液WBC分析模式和体液RBC分析模式中的至少一种，实现体液样本对应的运行模式的进一步细化，这样在进行复检时可以针对体液样本中的不同异常由用户选择不同的分析模式，指导细胞图像分析装置针对体液样本的不同异 常进行图像拍摄和分析，相对于现有针对体液样本的不同异常都采用体液分析模式这一运行模式来说，进一步提高细胞图像分析装置的处理效率和准确度。
在这里说明一点：若图17所示样本分析系统包括样本信息获取装置105，那么控制装置305可以从样本信息获取装置105中获取到待测样本的样本信息，然后控制装置305响应于复检指令时，模式指定界面直接显示与待测样本的样本信息中的样本类型信息对应的分析模式，如样本类型信息指示待测样本为血液样本，则控制装置305控制模式指定界面直接显示血液样本分析模式包括的分析模式，同样如果样本类型信息指示待测样本为体液样本，则控制装置305控制模式指定界面直接显示体液样本分析模式包括的分析模式。针对血液样本和体液样本来说，细胞图像分析装置可以对血液样本和体液样本中至少一种类型样本的样本涂片的指定区域内的全部细胞进行图像拍摄和分析，因此针对血液样本来说，在显示血液分析模式包括的分析模式的同时还可以显示全细胞分析模式。
在本实施例中，控制装置305也可以进行运行模式的追加，其中运行模式的追加是细胞图像分析装置在所选择的运行模式对样本涂片进行图像拍摄和分析完成之前或者是细胞图像分析装置在所选择的运行模式对样本涂片进行图像拍摄和分析的过程中，控制装置305进行运行模式的追加的可选方式如下：
控制装置305还配置用于：响应于用户根据待测样本的检测结果信息输入的追加复检指令，显示模式指定界面；接收追加模式选择指令，追加模式选择指令用于指示用户从模式指定界面中选择出细胞图像分析装置的追加运行模式；响应于追加模式选择指令，使细胞图像分析装置在所选择的运行模式下完成样本涂片的图像拍摄和分析之后调用追加运行模式对样本涂片进行图像拍摄和分析。
其中追加复检指令与复检指令类似，在接收到追加复检指令后模式指定界面的显示与接收到复检指令后模式指定界面的显示相同，具体请参见复检指令处的说明，控制装置305接收到的追加模式选择指令用于指示用户从模式指定界面中选择出一个不同于之前的运行模式的追加运行模式，以使得细胞图像分析装置能够在两个或两个以上模式下对样本涂片进行图像拍摄和分析。
通过上述图17所示的样本分析系统300，响应于复检指令，显示模式指定界面，由用户从预设分析模式集合中选择出细胞图像分析装置的运行模式。
对于上述图2、图16和图17所示的样本分析系统，各样本分析系统中的控制装置的一种可选的结构如图19所示，至少包括：处理组件111、RAM112、ROM113、通信接口114、存储器116和I/O接口115，其中，处理组件111、RAM112、ROM113、通信接口114、存储器116和I/O接口115通过总线117进行通信。
处理组件可以为CPU，GPU或其它具有运算能力的芯片。
存储器116中装有操作系统和应用程序等供处理器组件111执行的各种计算机程序及执行该计算机程序所需的数据。另外，在样本检测过程中，如有需要本地存储的信息，均可以存储到存储器116中。
I/O接口115由比如USB、IEEE1394或RS‐232C等串行接口、SCSI、IDE或IEEE1284等并行接口以及由D/A转换器和A/D转换器等组成的模拟信号接口构成。I/O接口115上连接有由键盘、鼠标、触摸屏或其它控制按钮构成的输入设备，用户可以用输入设备直接向控制装置110输入数据。另外，I/O接口115上还可以连接由具有显示功能的显示器，例如：液晶屏、触摸屏、LED显示屏等，控制装置可以以图像显示方式将信息输出到显示器上进行显示，例如：分析模式、检测结果信息等。
通信接口114是可以是目前已知的任意通信协议的接口。通信接口114通过网络与外界进行通信。控制装置可以通过通信接口114以一定的通信协议，与通过该网连接的任意装置之间传输数据。
下面以待测样本为血液样本为例，说明上述样本分析系统200的工作流程，其工作流程如下：
首先，血液细胞分析仪201对试管架上的待测的血液样本进行血常规检测，得到待测的血液样本的检测结果信息。控制装置205从血液细胞分析仪201获取待测样本的检测结果信息，当控制装置205根据检测结果信息，确定检测结果信息中指示有异常结果信息时，如检测结果信息中指示白细胞异常信息，此时控制装置205控制第一运送轨道将待测的血液样本运送至涂片制备装置202，以便涂片制备装置202制备待测样本的样本涂片；然后再控制第二运送轨道将样本涂片从涂片制备装置202运送到细胞图像分析装置203。
控制装置205进一步根据待测样本的检测结果信息，从预设分析模式集合中确定细胞图像分析装置的运行模式，例如检测结果信息中指示白细胞异常，则控制装置205将血液WBC分析模式作为细胞图像分析装置203的运行模式，并控制细胞图像分析装置在运行模式下对样本涂片进行图像拍摄和分析，如采用上述图8至图10所示方式进行图像拍摄，并对拍摄到的细胞图像进行分析。
图20示出了本发明实施例提供的样本分析方法的一种可选的流程图，可以包括：
401：获取待测样本的样本信息和血液细胞分析仪对待测样本的检测结果信息中的至少一种信息。
402：通过控制装置根据所获取的至少一种信息，从预设分析模式集合中确定细胞图像分析装置的运行模式。
403：使细胞图像分析装置调用运行模式对由涂片制备装置制备的待测样本的样本涂片进行图像拍摄和分析。
通过本实施例提供的样本分析方法能够根据待测样本的样本信息和待测样本的检测结果信息中的 至少一种信息，从预设分析模式集合中确定细胞图像分析装置的运行模式，实现运行模式的自动确定。对于本实施例提供的样本分析方法中各步骤的说明请参见上述系统实施例，对此本实施例不再阐述。
本发明实施例还提供一种存储介质，存储有可执行指令，配置为引起处理器执行所述可执行指令时，实现上述样本分析方法。
本领域内的技术人员应明白，本发明实施例可提供为方法、系统、或计算机程序产品。因此，本发明实施例可采用硬件实施例、软件实施例、或结合软件和硬件方面的实施例的形式。而且，本发明实施例可采用在一个或多个其中包含有计算机可用程序代码的计算机可用存储介质(包括磁盘存储器和光学存储器等)上实施的计算机程序产品的形式。
本发明实施例是参照根据本发明实施例的方法、设备(系统)、和计算机程序产品的流程图和/或方框图来描述的。应理解可由计算机程序操作实现流程图和/或方框图中的每一流程和/或方框、以及流程图和/或方框图中的流程和/或方框的结合。可提供这些计算机程序操作到通用计算机、专用计算机、嵌入式处理机或其他可编程数据处理设备的处理器以产生一个机器，使得通过计算机或其他可编程数据处理设备的处理器执行的操作产生用于实现在流程图一个流程或多个流程和/或方框图一个方框或多个方框中指定的功能的装置。
这些计算机程序操作也可存储在能引导计算机或其他可编程数据处理设备以特定方式工作的计算机可读存储器中，使得存储在该计算机可读存储器中的操作产生包括操作装置的制造品，该操作装置实现在流程图一个流程或多个流程和/或方框图一个方框或多个方框中指定的功能。
这些计算机程序操作也可装载到计算机或其他可编程数据处理设备上，使得在计算机或其他可编程设备上执行一系列操作步骤以产生计算机实现的处理，从而在计算机或其他可编程设备上执行的操作提供用于实现在流程图一个流程或多个流程和/或方框图一个方框或多个方框中指定的功能的步骤。
以上所述，仅为本发明的较佳实施例而已，并非用于限定本发明的保护范围，凡在本发明的精神和原则之内所作的任何修改、等同替换和改进等，均应包含在本发明的保护范围之内。

Claims (37)

  1. 一种样本分析系统，包括：
    血液细胞分析仪，用于对待测样本进行检测以获取检测结果信息；
    涂片制备装置，用于制备所述待测样本的样本涂片；
    细胞图像分析装置，用于对由所述涂片制备装置制备的样本涂片进行图像拍摄和分析；
    运送装置，包括第一运送轨道和第二运送轨道，第一运送轨道用于将所述待测样本从所述血液细胞分析仪运送到所述涂片制备装置，第二运送轨道用于将所述样本涂片从所述涂片制备装置运送到所述细胞图像分析装置；
    样本信息获取装置，用于获取所述待测样本的样本信息；
    控制装置，与所述血液细胞分析仪、所述涂片制备装置、所述细胞图像分析装置、所述运送装置和所述样本信息获取装置通信连接，并且配置用于：
    从所述血液细胞分析仪获取所述检测结果信息以及从所述样本信息获取装置获取所述待测样本的样本信息；
    当所述检测结果信息满足预定条件时，控制所述第一运送轨道将所述待测样本运送至所述涂片制备装置，以便所述涂片制备装置制备所述待测样本的样本涂片；
    控制所述第二运送轨道将所述样本涂片从所述涂片制备装置运送到所述细胞图像分析装置；
    根据所述待测样本的样本信息，从预设分析模式集合中确定所述细胞图像分析装置的运行模式；
    控制所述细胞图像分析装置在所述运行模式下对所述样本涂片进行图像拍摄和分析。
  2. 根据权利要求1所述的样本分析系统，其中，所述预设分析模式集合包括：对血液样本涂片中的细胞进行图像拍摄和分析的血液分析模式，不同于所述血液分析模式的对体液样本涂片中的细胞进行图像拍摄和分析的体液分析模式，以及不同于所述血液分析模式和所述体液分析模式的对样本涂片的指定区域内的全部细胞进行图像拍摄和分析的全细胞分析模式中的至少一种分析模式，所述控制装置进一步配置用于在根据所述待测样本的样本信息，从预设分析模式集合中确定所述细胞图像分析装置的运行模式时：
    根据所述待测样本的样本信息，从所述血液分析模式、所述体液分析模式和所述全细胞分析模式中的至少一种分析模式中确定所述细胞图像分析装置的运行模式。
  3. 根据权利要求2所述的样本分析系统，其中，所述样本信息包括样本类型信息和受试者信息，所述控制装置进一步配置用于在根据所述待测样本的样本信息，从预设分析模式集合中确定所述细胞图像分析装置的运行模式时采用如下至少一种方式：
    如果所述样本信息中的样本类型信息为血液样本，则将所述血液分析模式设定为所述细胞图像分析装置的运行模式；
    如果所述样本信息中的样本类型信息为体液样本，则将所述体液分析模式设定为所述细胞图像分析装置的运行模式；
    根据所述样本信息中的受试者信息，从所述预设分析模式集合中确定与所述受试者信息对应的分析模式作为所述细胞图像分析装置的运行模式。
  4. 根据权利要求3所述的样本分析系统，其中，所述受试者信息包括：科室信息、年龄、性别、用药信息和治疗信息中的至少一种；
    所述控制装置进一步配置用于根据所述科室信息、年龄、性别、用药信息和治疗信息中的至少一种，从所述预设分析模式中确定对应的分析模式为所述细胞图像分析装置的运行模式。
  5. 根据权利要求3或4所述的样本分析系统，其中，所述与所述受试者信息对应的分析模式为全细胞分析模式，从所述预设分析模式集合中确定全细胞分析模式为所述细胞图像分析装置的运行模式。
  6. 根据权利要求2所述的样本分析系统，其中，所述控制装置进一步配置用于：
    根据所述待测样本的样本信息和所述检测结果信息，从预设分析模式集合中确定所述细胞图像分析装置的运行模式。
  7. 根据权利要求6所述的样本分析系统，其中，所述血液分析模式进一步包括：对血液样本涂片中的白细胞进行图像拍摄和分析的血液WBC分析模式、对血液样本涂片中的红细胞进行图像拍摄和分析的血液RBC分析模式、对血液样本涂片中的血小板进行图像拍摄和分析的血液PLT分析模式中的至少一种。
  8. 根据权利要求7所述的样本分析系统，其中，所述血液RBC分析模式和所述血液PLT分析模式为同一种分析模式。
  9. 根据权利要求7或8所述的样本分析系统，其中，所述控制装置进一步配置用于在根据所述待测样本的样本信息和所述检测结果信息，从预设分析模式集合中确定所述细胞图像分析装置的运行模式时采用如下至少一种方式：
    如果所述样本信息中的样本类型信息为血液样本，且所述检测结果信息包含表明所述待测样本中的白细胞异常的异常结果信息，则将所述血液WBC分析模式设定为所述细胞图像分析装置的运行模式；
    如果所述样本信息中的样本类型信息为血液样本，且所述检测结果信息包含表明所述待测样本中的红细胞异常的异常结果信息，则将所述血液RBC分析模式设定为所述细胞图像分析装置的运行模式；
    如果所述样本信息中的样本类型信息为血液样本，且所述检测结果信息包含表明所述待测样本中的血小板异常的异常结果信息，则将所述血液PLT分析模式设定为所述细胞图像分析装置的运行模式；
    如果所述样本信息中的样本类型信息为血液样本，且所述检测结果信息表明所述待测样本中存在原始细胞，则将所述全细胞分析模式设定为所述细胞图像分析装置的运行模式。
  10. 根据权利要求6至9中任一项所述的样本分析系统，其中，所述体液分析模式进一步包括：对体液样本涂片中的白细胞进行图像拍摄和分析的体液WBC分析模式和对体液样本涂片中的红细胞进行图像拍摄和分析的体液RBC分析模式中的至少一种模式。
  11. 根据权利要求10所述的样本分析系统，其中，所述控制装置进一步配置用于在根据所述待测样本的样本信息和所述检测结果信息，从预设分析模式集合中确定所述细胞图像分析装置的运行模式时采用如下至少一种方式：
    如果所述样本信息中的样本类型信息为体液样本，且所述检测结果信息包含表明所述待测样本中的白细胞异常的异常结果信息，则将所述体液WBC分析模式设定为所述细胞图像分析装置的运行模式；
    如果所述样本信息中的样本类型信息为体液样本，且所述检测结果信息包含表明所述待测样本中的红细胞异常的异常结果信息，则将所述体液RBC分析模式设定为所述细胞图像分析装置的运行模式。
  12. 根据权利要求6至11中任一项所述的样本分析系统，其中，所述检测结果信息的异常结果信息包括如下信息的至少一种：所述待测样本的细胞检测参数对应的数值异常、所述待测样本中存在异常细胞、在设定间隔时间内从同一受试者获取的各个待测样本的同一细胞参数之间的差值超出预设范围。
  13. 根据权利要求1至12中任一项所述的样本分析系统，其中，所述细胞图像分析装置的运行模式包括一种或一种以上。
  14. 根据权利要求1至13中任一项所述的样本分析系统，其中，所述控制装置还配置用于：
    如果所述细胞图像分析装置在所述运行模式下识别到所述样本涂片中存在其他异常，则从所述预设分析模式集合中选择与所述其他异常对应的分析模式作为追加运行模式，并使所述细胞图像分析装置在所述追加运行模式下对所述样本涂片进行图像拍摄和分析，所述其他异常与所述运行模式下对应的异常不同。
  15. 根据权利要求14所述的样本分析系统，其中，所述控制装置还用于：
    使所述细胞图像分析装置在所述运行模式下完成对样本涂片的图像拍摄和分析之后调用所述追加运行模式对所述样本涂片进行图像拍摄和分析。
  16. 根据权利要求1至15中任一项所述的样本分析系统，其中，所述预定条件包括：所述检测 结果信息包含表明待测样本出现异常的异常结果信息。
  17. 一种样本分析系统，包括：
    血液细胞分析仪，用于对待测样本进行检测以获取检测结果信息；
    涂片制备装置，用于制备所述待测样本的样本涂片；
    细胞图像分析装置，用于对由所述涂片制备装置制备的样本涂片进行图像拍摄和分析；
    运送装置，包括第一运送轨道和第二运送轨道，第一运送轨道用于将所述待测样本从所述血液细胞分析仪运送到所述涂片制备装置，第二运送轨道用于将所述样本涂片从所述涂片制备装置运送到所述细胞图像分析装置；
    控制装置，与所述血液细胞分析仪、所述涂片制备装置、所述细胞图像分析装置和所述运送装置通信连接，并且配置用于：
    从所述血液细胞分析仪获取所述待测样本的检测结果信息，当所述检测结果信息满足预定条件时，控制所述第一运送轨道将所述待测样本运送至所述涂片制备装置，以便所述涂片制备装置制备所述待测样本的样本涂片；
    控制所述第二运送轨道将所述样本涂片从所述涂片制备装置运送到所述细胞图像分析装置；
    根据所述待测样本的样本信息和/或检测结果信息，从预设分析模式集合中确定所述细胞图像分析装置的运行模式；
    控制所述细胞图像分析装置在所述运行模式下对所述样本涂片进行图像拍摄和分析。
  18. 根据权利要求17所述的样本分析系统，其中，所述预设分析模式集合包括：对血液样本涂片中的白细胞进行图像拍摄和分析的血液WBC分析模式，对血液样本涂片中的红细胞进行图像拍摄和分析的血液RBC分析模式，对血液样本涂片中的血小板进行图像拍摄和分析的血液PLT分析模式，以及对血液样本涂片的指定区域内的全部细胞进行图像拍摄和分析的全细胞分析模式中的至少一种分析模式，所述控制装置进一步配置用于在根据所述待测样本的检测结果信息，从预设分析模式集合中确定所述细胞图像分析装置的运行模式时：
    根据所述待测样本的检测结果信息，从所述血液WBC分析模式、所述血液RBC分析模式、所述血液PLT分析模式和所述全细胞分析模式中的至少一种分析模式中确定所述细胞图像分析装置的运行模式。
  19. 根据权利要求18所述的样本分析系统，其中，所述血液RBC分析模式和所述血液PLT分析模式为同一种分析模式。
  20. 根据权利要求18或19所述的样本分析系统，其中，所述待测样本的样本信息包括：受试者 信息；所述控制装置进一步配置用于在根据所述待测样本的样本信息，从预设分析模式集合中确定所述细胞图像分析装置的运行模式时：
    根据所述受试者信息，从所述预设分析模式集合中确定与所述受试者信息对应的分析模式作为所述细胞图像分析装置的运行模式。
  21. 根据权利要求20所述的样本分析系统，其中，所述受试者信息包括：科室信息、年龄、性别、用药信息和治疗信息中的至少一种；
    所述控制装置进一步配置用于根据所述科室信息、年龄、性别、用药信息和治疗信息中的至少一种，从所述预设分析模式中确定对应的分析模式为所述细胞图像分析装置的运行模式。
  22. 根据权利要求20或21所述的样本分析系统，其中，所述与所述受试者信息对应的分析模式为全细胞分析模式，从所述预设分析模式集合中确定全细胞分析模式为所述细胞图像分析装置的运行模式。
  23. 根据权利要求21所述的样本分析系统，其中，所述科室信息指示预设科室，且所述预设科室对应的分析模式为全细胞分析模式，则所述控制装置进一步配置用于根据所述科室信息，从所述预设分析模式中确定全细胞分析模式设定为所述细胞图像分析装置的运行模式；或
    所述科室信息指示预设科室，且所述预设科室对应的分析模式为血液WBC分析模式、血液RBC分析模式、血液PLT分析，模式中的至少一种模式则所述控制装置进一步配置用于根据所述科室信息，从所述预设分析模式中确定血液WBC分析模式、血液RBC分析模式、血液PLT分析模式中至少一种模式为所述细胞图像分析装置的运行模式。
  24. 根据权利要求18或19所述的样本分析系统，其中，所述控制装置进一步配置用于在根据所述待测样本的检测结果信息，从预设分析模式集合中确定所述细胞图像分析装置的运行模式时采用如下至少一种方式：
    如果所述检测结果信息包含表明所述待测样本中的白细胞异常的异常结果信息，则将所述血液WBC分析模式设定为所述细胞图像分析装置的运行模式；
    如果所述检测结果信息包含表明所述待测样本中的红细胞异常的异常结果信息，则将所述血液RBC分析模式设定为所述细胞图像分析装置的运行模式；
    如果所述检测结果信息包含表明所述待测样本中的血小板异常的异常结果信息，则将所述血液PLT分析模式设定为所述细胞图像分析装置的运行模式；
    如果所述检测结果信息表明所述待测样本中存在原始细胞，则将所述全细胞分析模式设定为所述细胞图像分析装置的运行模式。
  25. 根据权利要求18至24中任一项所述的样本分析系统，其中所述控制装置进一步配置用于在根据所述待测样本的样本信息和所述检测结果信息，从预设分析模式集合中确定所述细胞图像分析装置的运行模式时：
    如果所述样本信息与所述预设分析模式集合中的第一分析模式对应，且所述检测结果信息与所述预设分析模式集合中不同于所述第一分析模式的第二分析模式对应，则将所述第一分析模式和所述第二分析模式都设定为所述细胞图像分析装置的运行模式。
  26. 根据权利要求18至25中任一项所述的样本分析系统，其中，所述检测结果信息的异常结果信息包括如下信息的至少一种：所述待测样本的细胞检测参数对应的数值异常、所述待测样本中存在异常细胞、在设定间隔时间内从同一受试者获取的各个待测样本的同一细胞参数之间的差值超出预设范围。
  27. 根据权利要求17至26任一项所述的样本分析系统，其中，所述细胞图像分析装置的运行模式包括一种或一种以上。
  28. 根据权利要求17至27中任一项所述的样本分析系统，其中，所述控制装置还配置用于：
    如果所述细胞图像分析装置在所述运行模式下识别到所述样本涂片中存在其他异常，则从所述预设分析模式集合中选择与所述其他异常对应的分析模式作为追加运行模式，并使所述细胞图像分析装置在所述追加运行模式下对由所述样本涂片进行图像拍摄和分析，所述其他异常与所述运行模式下对应的异常不同。
  29. 根据权利要求28所述的样本分析系统，其中，所述控制装置还用于：
    使所述细胞图像分析装置在所述运行模式下完成样本涂片的图像拍摄和分析之后调用所述追加运行模式对所述样本涂片进行图像拍摄和分析。
  30. 根据权利要求17至29任一项所述的样本分析系统，其中，所述控制装置还用于：
    接收模式设定指令，所述模式设定指令包括所述预设分析模式集合中各个分析模式与检测结果信息的对应关系；
    响应于所述模式设定指令，根据所述对应关系建立模式设定规则；
    根据所述模式设定规则和所述待测样本的检测结果信息，从所述预设分析模式集合中确定所述细胞图像分析装置的运行模式。
  31. 根据权利要求17至30任一项所述的样本分析系统，其中，所述预定条件包括：所述检测结果信息包含表明待测样本出现异常的异常结果信息。
  32. 一种样本分析系统，包括：
    血液细胞分析仪，用于对待测样本进行检测以获取检测结果信息；
    涂片制备装置，用于制备所述待测样本的涂片；
    细胞图像分析装置，用于对由所述涂片制备装置制备的样本涂片进行图像拍摄和分析；
    运送装置，包括第一运送轨道和第二运送轨道，第一运送轨道用于将所述待测样本从所述血液细胞分析仪运送到所述涂片制备装置，第二运送轨道用于将所述样本涂片从所述涂片制备装置运送到所述细胞图像分析装置；
    控制装置，与所述血液细胞分析仪、所述涂片制备装置、所述细胞图像分析装置和所述运送装置通信连接，并且配置用于：
    响应于用户根据所述检测结果信息输入的相应的复检指令，显示模式指定界面；
    接收模式选择指令，所述模式选择指令用于指示用户从所述模式指定界面中选择出细胞图像分析装置的运行模式；
    响应于所述模式选择指令，控制所述第一运送轨道将所述待测样本运送至所述涂片制备装置，以便所述涂片制备装置制备所述待测样本的样本涂片；
    控制所述第二运送轨道将所述样本涂片从所述涂片制备装置运送到所述细胞图像分析装置；
    控制所述细胞图像分析装置调用所选择的运行模式对所述样本涂片进行图像拍摄和分析。
  33. 根据权利要求32所述的样本分析系统，其中，所述模式指定界面显示的模式包括：对血液样本涂片中的细胞进行图像拍摄和分析的血液分析模式、不同于所述血液分析模式的对体液样本涂片中的细胞进行图像拍摄和分析的体液分析模式，以及不同于所述血液分析模式和所述体液分析模式的对样本涂片的指定区域内的全部细胞进行图像拍摄和分析的全细胞分析模式中的至少一种分析模式。
  34. 根据权利要求33所述的样本分析系统，其中，所述血液分析模式进一步包括：对血液样本涂片中的白细胞进行图像拍摄和分析的血液WBC分析模式、对血液样本涂片中的红细胞进行图像拍摄和分析的血液RBC分析模式、对血液样本涂片中的血小板进行图像拍摄和分析的血液PLT分析模式中的至少一种。
  35. 根据权利要求32或33所述的样本分析系统，其中，所述体液分析模式进一步包括：对体液样本涂片中的白细胞进行图像拍摄和分析的体液WBC分析模式和对体液样本涂片中的红细胞进行图像拍摄和分析的体液RBC分析模式中的至少一种。
  36. 根据权利要求32至35中任一项所述的样本分析系统，其中，所述控制装置还配置用于：
    响应于用户根据所述待测样本的检测结果信息输入的追加复检指令，显示模式指定界面；
    接收追加模式选择指令，所述追加模式选择指令用于指示用户从所述模式指定界面中选择出细胞 图像分析装置的追加运行模式；
    响应于所述追加模式选择指令，使所述细胞图像分析装置在所选择的运行模式下完成样本涂片的图像拍摄和分析之后调用所述追加运行模式对所述样本涂片进行图像拍摄和分析。
  37. 一种样本分析方法，包括：
    获取待测样本的样本信息和血液细胞分析仪对所述待测样本的检测结果信息中的至少一种信息；
    通过控制装置根据所获取的至少一种信息，从预设分析模式集合中确定细胞图像分析装置的运行模式；
    使细胞图像分析装置调用所述运行模式对由涂片制备装置制备的待测样本的样本涂片进行图像拍摄和分析。
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