WO2021118318A3 - Novel indole derivative and use thereof - Google Patents
Novel indole derivative and use thereof Download PDFInfo
- Publication number
- WO2021118318A3 WO2021118318A3 PCT/KR2020/018213 KR2020018213W WO2021118318A3 WO 2021118318 A3 WO2021118318 A3 WO 2021118318A3 KR 2020018213 W KR2020018213 W KR 2020018213W WO 2021118318 A3 WO2021118318 A3 WO 2021118318A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- indole derivative
- novel indole
- present
- end products
- advanced glycation
- Prior art date
Links
- 150000002475 indoles Chemical class 0.000 title abstract 3
- AIJULSRZWUXGPQ-UHFFFAOYSA-N Methylglyoxal Chemical compound CC(=O)C=O AIJULSRZWUXGPQ-UHFFFAOYSA-N 0.000 abstract 4
- 108010005094 Advanced Glycation End Products Proteins 0.000 abstract 2
- 230000001120 cytoprotective effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/132—Heterocyclic compounds containing only one nitrogen as hetero atom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/32—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the digestive tract
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/322—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the nervous system or on mental function
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/328—Foods, ingredients or supplements having a functional effect on health having effect on glycaemic control and diabetes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a novel indole derivative and a use thereof. The novel indole derivative of the present invention captures methylglyoxal (MGO), which is a major precursor of advanced glycation end products, and exhibits an excellent cytoprotective effect, thus finding advantageous applications in preventing or treating diseases associated with advanced glycation end products.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20190166432 | 2019-12-13 | ||
KR10-2019-0166432 | 2019-12-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2021118318A2 WO2021118318A2 (en) | 2021-06-17 |
WO2021118318A3 true WO2021118318A3 (en) | 2021-07-29 |
Family
ID=76330224
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2020/018213 WO2021118318A2 (en) | 2019-12-13 | 2020-12-11 | Novel indole derivative and use thereof |
Country Status (2)
Country | Link |
---|---|
KR (1) | KR102323893B1 (en) |
WO (1) | WO2021118318A2 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20220167441A (en) * | 2021-06-11 | 2022-12-21 | 주식회사 메타센테라퓨틱스 | Novel indole derivatives and their use for treating advanced glycation end products related diseases |
KR20220167804A (en) * | 2021-06-11 | 2022-12-22 | 주식회사 메타센테라퓨틱스 | Composition for treating advanced glycation endproducts related diseases comprising indole derivatives |
KR20230168288A (en) | 2022-06-03 | 2023-12-14 | 주식회사 메타센테라퓨틱스 | Novel strain having resistance against methylglyoxal and use thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR0171579B1 (en) * | 1989-02-08 | 1999-02-01 | 에밀리오 엠 루이즈 | Indole derivatives |
US20040167119A1 (en) * | 2003-02-11 | 2004-08-26 | Pharmacopeia, Inc | 2-(aminomethyl) arylamide analgesics |
KR100807718B1 (en) * | 2006-10-17 | 2008-02-28 | 한국생명공학연구원 | Pharmaceutical composition for the prevention and treatment of metabolic disorder containing indole derivatives as an active ingredient |
US9353078B2 (en) * | 2013-10-01 | 2016-05-31 | New York University | Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103755686B (en) * | 2014-01-23 | 2016-05-11 | 中国药科大学 | The piperidyl with platelet aggregation inhibitory activity replaces 5-hydroxyryptophan derivative |
-
2020
- 2020-12-11 KR KR1020200173809A patent/KR102323893B1/en active IP Right Grant
- 2020-12-11 WO PCT/KR2020/018213 patent/WO2021118318A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR0171579B1 (en) * | 1989-02-08 | 1999-02-01 | 에밀리오 엠 루이즈 | Indole derivatives |
US20040167119A1 (en) * | 2003-02-11 | 2004-08-26 | Pharmacopeia, Inc | 2-(aminomethyl) arylamide analgesics |
KR100807718B1 (en) * | 2006-10-17 | 2008-02-28 | 한국생명공학연구원 | Pharmaceutical composition for the prevention and treatment of metabolic disorder containing indole derivatives as an active ingredient |
US9353078B2 (en) * | 2013-10-01 | 2016-05-31 | New York University | Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof |
Non-Patent Citations (2)
Title |
---|
CRUCES, M. ; ELORRIAGA, C. ; FERNANDEZ-ALVAREZ, E. ; LOPEZ, O.N.: "Acetylenic and allenic derivatives of 2-(5-methoxyindolyl) methylamine: synthesis and evaluation as selective inhibitors of the monoamine oxidases A and B", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 25, no. 3, 1 April 1990 (1990-04-01), pages 257 - 265, XP023870613, ISSN: 0223-5234, DOI: 10.1016/0223-5234(90)90209-L * |
DATABASE REGISTRY 13 April 2007 (2007-04-13), ANONYMOUS: "1H-Indole-3-acetic acid, .alpha.-amino-5-hydroxy-, methyl ester (CA INDEX NAME)", XP055830828, retrieved from STN Database accession no. 2089704-91-4 * |
Also Published As
Publication number | Publication date |
---|---|
WO2021118318A2 (en) | 2021-06-17 |
KR20210076857A (en) | 2021-06-24 |
KR102323893B1 (en) | 2021-11-10 |
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