WO2021101572A1 - Appareil de perfusion ambulatoire alimenté par ressort - Google Patents

Appareil de perfusion ambulatoire alimenté par ressort Download PDF

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Publication number
WO2021101572A1
WO2021101572A1 PCT/US2019/062824 US2019062824W WO2021101572A1 WO 2021101572 A1 WO2021101572 A1 WO 2021101572A1 US 2019062824 W US2019062824 W US 2019062824W WO 2021101572 A1 WO2021101572 A1 WO 2021101572A1
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WO
WIPO (PCT)
Prior art keywords
spring
piston
infusion
infusion apparatus
module
Prior art date
Application number
PCT/US2019/062824
Other languages
English (en)
Inventor
Seik Oh
Original Assignee
Applied Infusion Technology, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Infusion Technology, Inc. filed Critical Applied Infusion Technology, Inc.
Priority to PCT/US2019/062824 priority Critical patent/WO2021101572A1/fr
Publication of WO2021101572A1 publication Critical patent/WO2021101572A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/1454—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons spring-actuated, e.g. by a clockwork
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/1456—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804—Flow controllers

Definitions

  • the present disclosure relates to a spring powered ambulatory infusion apparatus.
  • ambulatory infusion pumps there are three types of ambulatory infusion pumps, elastomeric bladder type pumps, pneumatic pumps and spring powered pumps.
  • the elastomeric bladder pump is relatively small and light-weighted.
  • the spring powered pump is more advantageous for providing a generally linear flow rate.
  • the size of the spring powered pump is generally bigger than the elastomeric bladder type pump.
  • a spring actuated infusion pump which may comprise: a syringe module configured to contain infusion medicine, wherein the syringe module comprises a syringe barrel and a piston, wherein the syringe barrel comprises a bottom and side walls extending from the bottom in a direction, wherein the syringe barrel further comprises an outlet for discharging infusion medicine, wherein the piston is disposed in the syringe barrel and movable in the direction, wherein the piston is configured to push infusion medicine contained in the syringe barrel toward the outlet; and an actuator module configured to engage with the syringe module, wherein the actuator module is further configured to push the piston in the direction, wherein the actuator module comprises a housing, two or more spring guide channels arranged side by side in the housing and two or more compression springs, each of which is retained in the corresponding spring guide channel, wherein each spring guide channel comprises an first end, a second end and a rounded portion between the first end and
  • each spring overlaps the piston when viewed in the direction.
  • the piston may have a generally rectangular shape when viewed in the direction, wherein the movable end of the first spring is configured to push the piston at a first corner of the piston, and the movable end of the second spring is configured to push the piston at a second corner of the piston that is diagonally opposite to the first corner.
  • Each spring may have a U-shape in the compressed state, and each spring has a J-shape in the expanded state and while the movable end moves in the direction.
  • each spring may be located in the housing of the actuator module in the compressed state and located in the syringe barrel in the expanded state while the fixed end is located in the housing of the actuator in both the compressed state and the expanded state. Both the movable end and the fixed end of each spring may face the piston in the compressed state and in the expanded state.
  • the bent portion of each spring in the compressed state may be partly deformed to extend linearly in the expanded state.
  • Each spring may be formed of a single wire that is coiled and interconnects the fixed end and the movable end.
  • each channel may further include a first straight extension connected to the first end and a second straight extension connected to the second end, and the rounded portion of each channel interconnects the first and second straight extensions.
  • the rounded portion may be semi-circular or arcuate.
  • the actuator module may further comprise a locking mechanism configured to maintain the springs in the compressed state. In the expanded state of the spring, the piston may contact the bottom of the syringe barrel.
  • the infusion apparatus may further comprise a pressure plate that contacts the movable end of each spring and is coupled to the piston to push the piston when the springs expand.
  • the actuator module may further comprise two or more buckling-prevention guides extending from the pressure plate, wherein the movable end of each spring is inserted in the corresponding buckling-prevention guide that has a bending stiffness greater than that of the corresponding spring.
  • Each buckling-prevention guide may comprise an end portion that is deformable and configured to deform in conformation with the rounded portion of the corresponding spring guide channel when the buckling-prevention guide is inserted in the corresponding guide channel.
  • the actuator module may further comprise two or more posts extending from the pressure plate, wherein each post is inserted in the movable end of the corresponding spring, and each post has a bending stiffness greater than that of the corresponding spring.
  • Each buckling-prevention guide may comprise telescopic pipes that receive the movable end of the spring, wherein each of the telescopic pipes is movable with respect to the rest of the telescopic pipes when the spring moves the piston in the direction.
  • Another aspect of the invention provide a method of infusing medicine to a patient, wherein the method may comprise: providing a syringe module containing infusion medicine therein, wherein the syringe module comprises a syringe barrel and a piston, wherein the syringe barrel comprises a bottom and side walls extending from the bottom in a direction, wherein the syringe barrel further comprises an outlet for discharging the medicine, wherein the piston is disposed in the syringe barrel and movable in the direction, wherein the piston is configured to push infusion medicine contained in the syringe barrel toward the outlet; providing an actuator module configured to push the piston in the direction when the actuator is engaged with the syringe module, wherein the actuator module comprises a housing, two or more spring guide channels arranged side by side in the housing and two or more compression springs, each of which is retained by the corresponding spring guide channel, wherein each spring guide channel comprises a first end, a second end and a rounded portion between the
  • the foregoing method may further comprise engaging another syringe module containing infusion medicine with the actuator module for infusion in which the springs are held in the compressed state, and releasing the springs from the compresses state for infusion.
  • each spring may have a El-shape in the compressed state before engaging, each spring becomes a J-shape after releasing and each spring becomes back to a El-shape after retracting.
  • Figure 1 is a perspective view of an infusion apparatus, showing a state thereof ready for use.
  • Figure 2 is a front view of the infusion apparatus shown in Figure T
  • Figure 3 is a top view of the infusion apparatus shown in Figure T
  • Figure 4 is a bottom view of the infusion apparatus shown in Figure 1.
  • Figure 5 is an exploded view of the infusion apparatus shown in Figure 1.
  • Figures 6, 7 and 8 are sectional views of the infusion apparatus taken along line A-A in Figure 3, in which Figure 6 shows a state ready for use, Figure 7 shows a state when infusion is being performed and Figure 8 shows a state when infusion is completed.
  • Figure 9 is a section view of the infusion apparatus taken along line B-B in Figure 8 for showing locations of buckling-prevention structures and springs according to one implementation.
  • Figure 10 is a perspective view of an infusion apparatus, showing a state when infusion is completed.
  • Figure 11 is a perspective cutaway view of the infusion apparatus shown in Figure 9, in which springs are not shown.
  • Figures 12, 13 and 14 are sectional views of an infusion apparatus according to another implementation, taken along line A-A in Figure 3, in which Figure 12 shows a state ready for use, Figure 13 shows a state when infusion is being performed and Figure 14 shows a state when infusion is completed.
  • Figures 15A-15C show various shapes of a spring used in an infusion apparatus according to one implementation, in which Figure 15A shows the spring in its unbent, compressed state and bent, compressed state shown in Figures 1 and 6 to compare its height, Figure 15B shows the spring in its unbent, expanded state and its bent, expanded state shown in Figure 8 to compare its height, and Figure 15C shows the spring which is unbent and free of exterior force.
  • Figure 16 is a graph showing changes of spring force changes of various springs that can be used in an infusion apparatus.
  • Figure 17 is a graph for comparing infusion pressure changes of various infusion devices.
  • Figure 18 is a perspective view of an infusion apparatus, showing a state thereof before an actuator and a syringe are engaged with each other, in which infusion fluid is filled in the syringe barrel.
  • Figure 19 is a perspective view of an infusion apparatus, showing a state thereof before an actuator and a syringe are engaged with each other, in which infusion fluid is not filled in the syringe barrel.
  • Figure 20 is a perspective view of the infusion apparatus, showing a state when infusion fluid is supplied into the syringe barrel.
  • Figure 21 is a perspective view of an infusion system, showing that the infusion apparatus shown in Figure 1 is connected to a flow regulator via a tube.
  • a spring powered infusion apparatus includes a syringe module and an actuator module.
  • the syringe module includes a syringe barrel and a piston that is inserted and movable in the syringe barrel.
  • the actuator module is attached to one end of the syringe module.
  • the infusion apparatus has a height smaller than that of typical spring powered infusion pumps.
  • the infusion apparatus has a generally rectangular sectional shape that has a width and a thickness as shown in Figures 1, 3 and 4.
  • the actuator module includes compression springs to push the piston for discharging medicine fluid contained in the syringe barrel when the compression springs expand.
  • compression springs to push the piston for discharging medicine fluid contained in the syringe barrel when the compression springs expand.
  • Relatively long compression springs may provide the above characteristics.
  • the longer the spring is the bigger the size of the infusion apparatus (in particular, the height of the apparatus) is.
  • the infusion apparatus according to implementations of the present invention provides improved spring configuration for reducing the height of the apparatus while providing an accurate flow rate or a uniform flow rate.
  • the actuator module uses multiple compression springs (e.g., two springs) that are relatively long to provide an accurate flow rate. To reduce the height of the apparatus, however, each compression spring of the actuator module is bent to have a U-shape or J-shape.
  • the actuator module two compression springs are not only bent but also arranged side by side such that the two springs can fit through or be accommodated in the rectangular sectional shape of the infusion apparatus having the width and the thickness.
  • the spring powered infusion apparatus according to implementations has a reduced size while not compromising advantages of providing accurate flow rates.
  • an infusion apparatus 100 includes a syringe module 200 and an actuator module or a pump module 300.
  • the syringe module 200 can contain infusion fluid, and includes a syringe barrel 210 and a piston 250 inserted in the syringe barrel 210.
  • the piston 250 can move to pressurize the infusion medicine for infusion.
  • the actuator module 300 is coupled to the syringe barrel 210, and includes compression springs for pushing the piston 250 using spring force.
  • the syringe barrel 210 may be made of a transparent or translucent plastic material for showing the infusion fluid.
  • the syringe barrel 210 may include scale markings on its wall for measuring the amount of the infusion fluid contained therein.
  • the syringe barrel 210 includes a nozzle 212.
  • a flexible infusion tube may be connected to the nozzle 212.
  • the syringe barrel 210 has a generally rectangular sectional shape with four rounded corners, as shown in Figures 3 and 9. But, the invention is not limited thereto.
  • the sectional shape of the syringe barrel 210 may be, for example, square or oval.
  • the piston 250 includes a piston body 252 and seals 254 covering the piston body 252.
  • the seals 254 contact the sidewalls of the syringe barrel 210 for sealing between the piston and the sidewalls.
  • the actuator module 300 includes a housing 302 and two U- shape spring guide tubes 310 and 312 that are accommodated and fixed in the housing 302.
  • the actuator module 300 further includes two compression springs 320 and 322 that are inserted in the guide tubes 310 and 312, respectively.
  • the actuator module 300 further includes a pressure plate 340 that receives spring force from the springs 320 and 322.
  • the pressure plate 340 is coupled to the piston 250 and transmits the spring force to the piston 250.
  • the actuator module 300 also includes a locking mechanism that locks or unlocks the movement of the pressure plate 340 of the actuator module 300.
  • the housing 302 includes a front member 304 and a rear member 306 that are coupled to each other and define a space for accommodating the tubes 310 and 312. Further, to provide secure engagement of the actuator module 300 and the syringe module 200, the housing 302 has a coupling structure that can engage with a counterpart coupling structure of the syringe barrel 210. The secure engagement is maintained during infusion of the infusion fluid.
  • the U-shape spring guide tubes 310 and 312 are arranged side by side in the housing 302 and fixed to the housing 302.
  • Each of the guide tubes 310 and 312 includes a first end 314 and a second end 316 and a rounded channel portion 318 that interconnects the first end 314 and the second end 316.
  • Each of the spring guide tubes 310 and 312 further includes a linear channel portion between the first end 314 and the rounded channel portion 318, and another linear channel portion between the second end 316 and the rounded channel portion 318.
  • the housing 302 includes outer walls, inner walls and bottom walls 307 and 308.
  • the outer walls, inner walls and bottom walls define a space for receiving the tubes 310 and 312.
  • the bottom wall 308 closes or blocks the second end 316 of the tube 310.
  • the bottom wall 307 includes a hole that communicates with the first end 314 of the tube 310.
  • the bottom wall 307 closes or blocks the second end 316 of the tube 312.
  • the bottom wall 308 includes a hole that communicates with the first end 314 of the tube 312.
  • the second end 316 of the guide tube 310 is closed or blocked by the bottom wall 308 and located at the right side of the actuator 312, and the first end 314 of the guide tube 310 is open through the hole of the bottom wall 307 and located at the left side of the actuator 312.
  • the second end 316 of the tube 312 is closed or blocked by the bottom wall 307 and located at the left side of the actuator module 300, and the first end 314 of the tube 312 is open through the hole of the bottom wall 308 and located at the right side of the actuator module 300.
  • Each of the compression springs 320 and 322 are inserted in the corresponding one of the guide tubes 310 and 312.
  • the springs 320 and 322 are bent to have a U-shape or J-shape.
  • the springs 320 and 322 are at least partly accommodated in the tube 310 and 312.
  • substantially the entire portion of each of the springs 320 and 322 is accommodated in the corresponding tube in the fully compressed state.
  • each spring 320 or 322 in fully compressed state, is accommodated in the corresponding guide tube and forms a U-shape.
  • a portion of each spring is still bent and accommodated in the corresponding tube, while the rest of the spring is located outside the tube and extends linearly such that the spring forms a J-shape.
  • each spring is formed of a single wire which is helically coiled.
  • the spring 320 includes a stationary end or fixed end 324 that contacts and is supported by the bottom wall 308 located on the right side of the actuator and a movable end 326 that can move through the hole formed in the bottom wall 307 located at the left side of the actuator 300.
  • the movable end 326 moves linearly along the center axis and pushes the pressure plate 340.
  • the fixed end 324 of the spring 320 pushes the bottom wall 308, but does not move as the bottom wall 308 functions as a stopper or spring support.
  • the fixed end 324 may be firmly secured to the bottom wall 308 or may be placed over the bottom wall 308 without firm attachment to the bottom wall 308.
  • the spring 322 includes a stationary end or fixed end 324 that contacts and is supported by the bottom wall 307 located on the left side of the actuator and a movable end 326 that can move through the hole formed in the bottom wall 308 located at the right side of the actuator 300.
  • the movable end 326 moves linearly along the center axis and pushes the pressure plate 340.
  • the fixed end 324 of the spring 322 pushes the bottom wall 307, but does not move as the bottom wall 307 functions as a stopper or spring support.
  • the fixed end 324 of the spring 322 may be firmly secured to the bottom wall 307 or may be placed over the bottom wall 307 without firm attachment to the bottom wall 307.
  • the fixed end 324 is locate at the right side of the actuator module 300, and the movable end 326 of the spring 320 is located at the left side of the actuator module 300.
  • the fixed end 324 of the spring 322 is locate at the left side of the actuator module 300 and the movable end 326 of the spring 322 is located at the right side of the actuator module 300.
  • each of the spring 320 and 322 is bent in the corresponding guide tube 310 or 312 such that each spring includes a bent portion between two ends 324 and 326.
  • both the fixed end 324 and the movable end 326 face the piston 250.
  • the force at the movable end 326 of the spring 320 is applied to the piston 250 while the force at the fixed end 324 of the spring 320 is applied to the corresponding bottom wall 308.
  • the force at the movable end 326 of the spring 322 is applied to the piston 250 while the force at the fixed end 324 of the spring 322 is applied to the corresponding bottom wall 307.
  • the supporting walls 307 and 308 are generally perpendicular to the center axis, but not limited thereto.
  • the locations and angles of the supporting walls can vary and may cause the fixed ends of the springs to face in another direction which forms an acute angle with the center axis.
  • the movable end 326 of the spring 320 pushes at a left-front corner 345 of the pressure plate 340 whereas the movable end 326 of the spring 322 pushes at a right-rear corner 347 of the pressure plate 340.
  • the movable ends 326 are arranged diagonally with respect to the center axis of the apparatus 100.
  • the movable end 326 of the spring 320 is distanced from the center axis of the apparatus 100 by a distance which is substantially the same as a distance by which the movable end 326 of the spring 322 is distanced from the center axis of the apparatus 100.
  • the bent spring 320 has a width that is a dimension between the movable end and the fixed end measured in a width direction of the infusion apparatus and a thickness that is a dimension measured in a thickness direction of the infusion apparatus.
  • the width of the spring 320 is smaller than that of the syringe barrel, and the thickness of the spring 320 is smaller than a half the thickness of syringe barrel.
  • the bent spring 322 has dimensions substantially the same as those of the spring 320. Size of bent shape springs in width direction of infusion apparatus
  • the bent springs 320 and 322 have a dimension in the width direction smaller than the width of the syringe barrel.
  • the bent springs 320 and 322 can be arranged side by side and located closely to each other such that both the bent springs 320 and 322 can be accommodated or fit through the rectangular sectional shape of the actuator when viewed from the top of the actuator along the center axis.
  • both the springs 320 and 322 in a top view, both the springs 320 and 322 can be accommodated or fit through a rectangular sectional shape of the piston.
  • the entire portion of the springs 320 and 322 can overlap the piston 250 in a viewing direction along the center axis.
  • the invention is not limited thereto.
  • the spring may have a portion that does not overlap the piston in a top view.
  • the actuator module 300 When expanding, a portion of each of the springs 320 and 322 comes out of the corresponding one of the guide tubes 310 and 312 and moves along the center axis in the syringe barrel 210. This portion of each spring may be subject to buckling during expansion.
  • the actuator module 300 further includes structures for preventing the springs 320 and 322 from buckling.
  • the actuator module 300 includes two buckling-prevention guides 342 and 343.
  • the guide 342 and 343 are fixed to the pressure plate 340.
  • Each of the guides 342 or 343 extends upwardly from the pressure plate 340 for receiving the movable end 326 of the corresponding spring 320 or 322.
  • Each guide 342 or 343 includes a rigid pipe portion 344 and a bendable portion 346 extending from the rigid portion 344.
  • the bendable spring portion 346 can be bent in conformation with the rounded or curved portion of the corresponding tube 310 or 312 as shown in Figure 6.
  • each of the rigid portion and the bendable portion 346 has a bending stiffness greater than that of the springs 320 and 322 and sufficient to prevent the spring 320 or 322 from buckling when the bendable portion is out of the tube as shown in Figure 8.
  • the bendable portion 346 has a spring-like shape.
  • the buckling-prevention guide may be made of a material the same as that of the pressure plate.
  • the buckling-prevention guide has a length the same as or slightly greater than a distance between the pressure plate 340 and the first end of the tube 310 or 312. The distance is measured when the pressure plate 340 is located at its lowest position.
  • a distal end portion of the buckling-prevention guide is located in and supported by the corresponding guide tube. This configuration provides more effective buckling- prevention function as the proximal end is fixed to the pressure plate 340 and the distal end is restricted by the corresponding guide tube.
  • the length of the buckling-prevention guide may be slightly smaller than the distance between the pressure plate 340 and the first end of the tube.
  • Each buckling-prevention guide 342 or 343 has an inner diameter slightly greater than an outer diameter of the spring 320 or 322, and the buckling-prevention guide 342 or 343 has an outer diameter slightly smaller than an inner diameter of the tube 310 or 312.
  • the tubes 310 and 312 can receive the guides 342 and 343, respectively, and the springs 320 and 322 can be at least partly retained in the guides 342 and 343, respectively.
  • each tube includes a portion having an enlarged inner diameter for receiving the corresponding buckling-prevention guide.
  • the buckling-prevention structure is a pole 348 that extends from the pressure plate and is inserted in the spring as shown in Figure 8.
  • the pole 348 may be a pipe or a rod.
  • the pole 348 is deformable and deforms in conformation with the rounded portion of the corresponding U-shape guide tube when the spring 320 or 322 is received in the corresponding tube 310 or 312 in the compressed state.
  • the pole 348 has a bending stiffness greater than that of the springs and sufficient to prevent the spring 310 or 312 from buckling when the pole 348 is out of the tube as shown in Figure 8.
  • the actuator module 300 may include both the spring-receiving guides 342 and 343 and the inserting poles 348.
  • the actuator module 300 includes two telescopic buckling-prevention structures 1342 and 1343 that may be fixed to the pressure plate 340.
  • the telescopic pipe structure 1342 includes two or more pipes that can expands and collapses. In a collapsed state, the telescopic pipe structure 1342 can be received in the linear channel portion of the U-shape tube 310, and there is no need to bend any portion of the telescopic pipe structure to be received in the U-shape tube 310.
  • each pipe of the telescopic pipe structure can have a bending stiffness greater than that of the bendable portion 346 shown in Figure 6.
  • the telescopic pipe structure 1342 has a bending stiffness greater than that of the springs 320 and 322 and sufficient to prevent the spring 320 from buckling when the telescopic pipe structure expands as shown in Figure 14.
  • the telescopic pipe structure 1343 can have the same structure and function as those of the telescopic pipe structure 1342, while the telescopic pipe structure 1343 receives the spring 322 and is received in the U-shape tube 312.
  • Each of the telescopic pipe structures 1342 and 1343 includes an inner pipe 1344 and an outer pipe 1346 receiving the inner pipe 1344.
  • the inner pipe 1344 includes a bottom end fixed to the pressure plate 340.
  • the spring 320 or 322 pushes the pressure plate 340, the inner pipe 1344 moves relative to the outer pipe 1346 along the center axis until the outward flange of the inner pipe 1344 contacts the inward flange of the outer pipe 1346. Then, the inner pipe 1344 and the outer pipe 1346 move together along the center axis until the piston reaches the bottom wall of the syringe barrel 210.
  • the outer pipe 1346 further includes an outward flange at the top thereof and the U-shape tube 310 or 312 includes an inward flange cooperating with the outward flange of the outer pipe 1346 to inhibit the outer pipe from being separated from the U-shape tube.
  • the actuator module 300 includes a locking mechanism for maintaining the compressed state of the springs 320 and 322.
  • the locking mechanism includes a locking knob 352 coupled to the housing 310 and a locking post 354 attached to the pressure plate 340 and capable of engaging with the locking knob 352.
  • the locking knob 352 can rotate about a knob axis perpendicular to the center axis.
  • the knob 352 includes a cylindrical body 356 that includes protrusions 358 diametrically arranged on outer surface of the body 356.
  • the locking post 354 includes a recess 360 for receiving the cylindrical body 356 and mating protrusions 362 formed on opposing surfaces of the recess 360.
  • the protrusions 358 of the knob and the protrusions 362 of the locking post 354 can engage with each other by snap-fitting.
  • Figure 6 shows the engagement of the protrusions 356 and 358. When rotating the knob 352, the engagement is released, which allows the springs 320 and 322 to expand as shown in Figure 7 and 8.
  • the springs 320 and 322 are compressed and accommodated in the tubes 310 and 312, respectively.
  • the springs 320 and 322 may be fully compressed.
  • the locking mechanism inhibits the pressure plate 340 from moving although the compressed springs 320 and 322 apply force to the pressure plate 340.
  • the substantially entire portion of each of the springs 320 and 322 is re retained in the corresponding guide tube 310 or 312, whereas the movable end may be located slightly outside the tube in the locked state in another implementation.
  • the buckling- prevention guides 342 and 343 are also retained in the guide tubes 310 and 312, in which the deformable portions 346 are bent in conformation with the rounded portions 318 of the corresponding tubes 310 and 312.
  • each of the springs 320 and 322 has a U-shape.
  • the buckling-prevention guides 342 and 343 prevent the springs 320 and 322 from buckling during the expansion of the springs 320 and 322.
  • the compression springs 320 and 322 When the springs 320 and 322 expand, at least a portion of each spring that is bent and located in the tube comes out of the corresponding tube and extends linearly. Therefore, the compression springs 320 and 322 are transformed from the U-shape to a J-shape during expansion. Further, the compression springs 320 and 322 push linearly the pressure plate 340 at the opposite sides of the piston 250, respectively, as the movable ends 326 of the springs 320 and 322 move linearly.
  • Figure 8 shows the completion of infusion when the piston 250 stops by the bottom of the syringe barrel 210.
  • the springs 320 and 322 expand to have a length smaller than their free length.
  • ratio of free length of the helical spring to the length of syringe barrel (which is a travel distance of the piston) is greater than about 6:1.
  • Ratio of free length to the solid length of the helical spring is greater than about 4:1.
  • springs are bent in a U-shape or J-shape.
  • Figure 15 A shows the spring in its unbent, compressed state and bent, compressed state shown in Figures 1 and 6.
  • the spring has a height of 2 inch in its bent, compressed state while the spring has a height of 4.6 inch in its unbent, compressed state.
  • Figure 15B shows the spring in its unbent, expanded state and its bent, expanded state shown in Figure 8.
  • the spring has a height of 4.5 inch in its bent, expanded state while the spring has a height of 7.1 inch in its unbent, expanded state.
  • Figure 15C shows the spring which is unbent and free of exterior force, in which the spring has a height of 16 inch. It is notable that when the springs 320 are 322 are used without bending, the height of the infusion apparatus is much greater than when the springs are used in their bent state.
  • the springs 320 and 322 do not have a portion that is located outside sidewalls of the syringe barrel 210 when viewing the springs 320 and 322 along the center axis.
  • outer dimensions of syringe barrel 210 may define the width and the thickness of the apparatus.
  • Figure 16 shows various examples of changes in spring force of various springs listed in Table 1 below.
  • the apparatus 100 provides better flow rate accuracy, i.e., least pressure (flow rate) variation from beginning of infusion to end of infusion. When combined with a pressure regulator, flow rate accuracy is even competitive with electronic pumps.
  • line 901 shows the pressure change of the apparatus without a regulator
  • line 903 shows the pressure change of the apparatus with a regulator. Comparing with line 905 showing the pressure changes of an elastomeric bladder type pump and lines 907 and 909 showing the pressure changes of other spring powered pumps, the infusion apparatus 100 according to implementations of the invention is significantly advantageous in the aspect of the flow rate accuracy.
  • an infusion system includes the infusion apparatus 100 shown in Figure 1, and a flow regulator 50 connected to the infusion apparatus 100 via a tube 54.
  • Infusion fluid is discharged from the infusion apparatus 100 and flows through the regulator 50, being supplied to a patient.
  • the flow rate accuracy of the infusion fluid is further improved when the infusion fluid is supplied via the regulator 50.
  • the regulator 50 can be any one of the infusion apparatuses discussed above.
  • the flow regulator may be one disclosed in U.S. Patent No. 8,905,064, the disclosure of which is incorporated by reference in its entirety.
  • the syringe module 200 is separated from the actuator module 300.
  • the separated syringe module 200 is discarded, and the actuator module 300 may be reused.
  • the knob 352 is rotated in its locking state.
  • the pressure plate 340 is pushed back to compress the springs 320 and 322.
  • each buckling-prevention structure 342 or 343 is received in the corresponding tube 310 or 312.
  • each buckling-prevention structure 1342 or 1343 is received in the corresponding tube 310 or 312.
  • both the actuator module 300 and the syringe module 200 are discarded after completion of infusion without reusing.
  • a patient user can receive the infusion apparatus 100 in its assembled state from a supplier, for example, a pharmaceutical company, a health care provider or a pharmacist.
  • the actuator module 300 is engaged with the syringe module 200 that is filled with infusion fluid.
  • a user can separate the syringe module 200 from the actuator module 300, and disposed the syringe module 200 while keeping the actuator module 300 for reuse.
  • a new syringe module 200 can be supplied to a patient user that uses a used actuator module from a medicine supplier, for example, a health care provider or a pharmacist.
  • the user receives the syringe module 200 that is filled with infusion medicine.
  • the piston is located at the top of the syringe barrel 210.
  • the top of the syringe module 200 may be sealed with a cover sheet. A patient user takes off the cover sheet and can assemble the syringe module 200 with the used or new actuator module 300 for infusion.
  • an empty syringe module 200 is first engaged with the actuator module 300 as shown in Figure 19. And then, infusion fluid is supplied into the syringe barrel 210 through the nozzle as shown in Figure 20.
  • the springs are compressed and restricted by the locking mechanism and does not resist movement of piston toward the actuator. Thus, almost no pressure is required to fill the syringe barrel.
  • the configuration of the infusion apparatus provides the following advantages:

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un appareil de perfusion ambulatoire alimenté par ressort comprenant un module de seringue et un module d'actionneur. Le module de seringue comprend un cylindre de seringue pour contenir un médicament de perfusion et un piston pour évacuer le médicament de perfusion. Le module d'actionneur comprend des ressorts de compression pour déplacer le piston lorsque les ressorts se déploient. Chaque ressort est plié pour réduire sa longueur totale et pour présenter une forme en U dans son état comprimé et une forme en J dans son état déployé. Lorsque chaque ressort se déploie, une extrémité du ressort se déplace pour pousser le piston tandis que l'autre extrémité est stationnaire de telle sorte que sa forme passe de la forme en U à la forme en J.
PCT/US2019/062824 2019-11-22 2019-11-22 Appareil de perfusion ambulatoire alimenté par ressort WO2021101572A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/US2019/062824 WO2021101572A1 (fr) 2019-11-22 2019-11-22 Appareil de perfusion ambulatoire alimenté par ressort

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Application Number Priority Date Filing Date Title
PCT/US2019/062824 WO2021101572A1 (fr) 2019-11-22 2019-11-22 Appareil de perfusion ambulatoire alimenté par ressort

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4755172A (en) * 1987-06-30 1988-07-05 Baldwin Brian E Syringe holder/driver and syringe arrangement and syringe/holder driver therefor
US5800405A (en) * 1995-12-01 1998-09-01 I-Flow Corporation Syringe actuation device
WO2009039203A2 (fr) * 2007-09-17 2009-03-26 Satish Sundar Contrôleur de pompe à perfusion de haute précision
US20140163521A1 (en) * 2012-12-12 2014-06-12 Animas Corporation Medical infusion pump mechanism
US8905064B2 (en) 2011-10-03 2014-12-09 Seik Oh Flow regulator for infusion pump and method of manufacturing the same
US20150094684A1 (en) * 2010-05-12 2015-04-02 Valerie B. Kriesel Apparatus for Dispensing Medicinal Fluids and Method of Making Same
WO2018136194A1 (fr) * 2017-01-17 2018-07-26 West Pharma. Services IL, Ltd. Injecteur actionné par ressort incurvé

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4755172A (en) * 1987-06-30 1988-07-05 Baldwin Brian E Syringe holder/driver and syringe arrangement and syringe/holder driver therefor
US5800405A (en) * 1995-12-01 1998-09-01 I-Flow Corporation Syringe actuation device
WO2009039203A2 (fr) * 2007-09-17 2009-03-26 Satish Sundar Contrôleur de pompe à perfusion de haute précision
US20150094684A1 (en) * 2010-05-12 2015-04-02 Valerie B. Kriesel Apparatus for Dispensing Medicinal Fluids and Method of Making Same
US8905064B2 (en) 2011-10-03 2014-12-09 Seik Oh Flow regulator for infusion pump and method of manufacturing the same
US20140163521A1 (en) * 2012-12-12 2014-06-12 Animas Corporation Medical infusion pump mechanism
WO2018136194A1 (fr) * 2017-01-17 2018-07-26 West Pharma. Services IL, Ltd. Injecteur actionné par ressort incurvé

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