WO2021093225A1 - Organ fat incisionless quantitative detection system based on principles of magnetic resonance - Google Patents

Organ fat incisionless quantitative detection system based on principles of magnetic resonance Download PDF

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WO2021093225A1
WO2021093225A1 PCT/CN2020/077600 CN2020077600W WO2021093225A1 WO 2021093225 A1 WO2021093225 A1 WO 2021093225A1 CN 2020077600 W CN2020077600 W CN 2020077600W WO 2021093225 A1 WO2021093225 A1 WO 2021093225A1
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radio frequency
magnetic resonance
subsystem
module
quantitative detection
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PCT/CN2020/077600
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French (fr)
Chinese (zh)
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吴子岳
纳亚克·克里希纳
王超
陈潇
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无锡鸣石峻致医疗科技有限公司
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/4616—NMR spectroscopy using specific RF pulses or specific modulation schemes, e.g. stochastic excitation, adiabatic RF pulses, composite pulses, binomial pulses, Shinnar-le-Roux pulses, spectrally selective pulses not being used for spatial selection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32—Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/36—Electrical details, e.g. matching or coupling of the coil to the receiver
    • G01R33/3607—RF waveform generators, e.g. frequency generators, amplitude-, frequency- or phase modulators or shifters, pulse programmers, digital to analog converters for the RF signal, means for filtering or attenuating of the RF signal

Definitions

  • the invention relates to the technical field of nuclear magnetic resonance medical detection, in particular to a non-invasive quantitative detection system for organ fat based on the principle of magnetic resonance.
  • NAFLD non-alcoholic fatty liver disease
  • the invention adopts a radio frequency RF subsystem, a portable magnet module and a data processing and display module to jointly construct a low-field nuclear magnetic resonance system.
  • the low-field nuclear magnetic resonance system acts on the human body, there is no damage and no wound to organs, tissues and cells. Realize accurate, non-invasive, and safe quantitative detection of organ fat. It has the characteristics of being portable, cost-effective, and accurate quantification.
  • the operation is convenient and not restricted by the qualifications of the operators, and the "one-click" detection can be realized in a few minutes, which can be used to quickly and economically screen for NAFLD, metabolic syndrome, non-alcoholic steatohepatitis (NASH) and other related diseases, with a wide range of applications .
  • NAFLD nuclear RF subsystem
  • MASH non-alcoholic steatohepatitis
  • the purpose of the present invention is to provide a non-invasive quantitative detection system for organ fat based on the principle of magnetic resonance, which reasonably solves the problem that the prior art organ fat detection adopts tissue slice biopsy, which is expensive and damaged, and is not suitable for early screening detection and conventional ultrasound. Imaging detection is subjective, the reliability of the results is poor, and quantitative detection cannot be achieved.
  • a non-invasive quantitative detection system for organ fat based on the principle of magnetic resonance including a portable magnet module, a radio frequency RF subsystem, a data processing and display module, and is characterized by:
  • the portable magnet module is provided with a portable magnet, and the portable magnet setting method includes at least a small single-sided magnet, the portable magnet is set as an ergonomic curved surface that fits the body surface adjacent to the target sample organ, and the back is connected
  • a magnetic yoke is provided with a handle connected to the back of the magnetic yoke, and the portable magnet module generates a static magnetic field B 0 for polarizing hydrogen atoms in the region of interest (ROI) of the target sample.
  • the static magnetic field B 0 determines the precession frequency of hydrogen atoms under nuclear magnetic resonance conditions and the frequency corresponding to the radio frequency.
  • the field strength of B 0 allows large spatial changes within the ROI, and rapid attenuation outside the ROI to minimize safety and interference problem;
  • the radio frequency RF subsystem includes an NMR spectrometer, a power amplifier, a preamplifier, and one or more radio frequency coils.
  • the radio frequency coil generates a pulse vector magnetic field B 1 in a detection area, and the pulse vector magnetic field B 1 In the ROI, it should not be parallel to the static magnetic field B 0. If it is orthogonal, the efficiency is the highest.
  • the frequency of the pulse vector magnetic field B 1 is adjustable to match the Larmor frequency at different positions in the ROI.
  • the Larmor frequency is the 1 H gyromagnetic ratio multiplied by the B 0 field strength.
  • the radio frequency RF subsystem also includes an NMR spectrometer for controlling the transmitted radio frequency pulse vector magnetic field, which drives one or more of the radio frequency coils to excite The target detects the hydrogen atoms in the sample and generates a detectable signal, also known as a magnetic resonance signal or echo.
  • the NMR spectrometer is also used to control and receive the signals collected from one or more of the radio frequency coils and store them;
  • the data processing and display module includes at least one processor and a user interface programmed to calculate the proton density fat content based on the signal.
  • the user interface is used for the visualization of the organ fat ratio, displaying measurement confidence and other diagnostic information,
  • the system is also used to combine other patient-specific information from other tests, records or imaging studies for convenient comprehensive interpretation;
  • the organ fat non-invasive quantitative detection system is equipped with a radio frequency RF subsystem and a portable magnet module to construct a low-field nuclear magnetic resonance system, which does not damage organs, tissues and cells when the low-field nuclear magnetic resonance system acts on the human body.
  • the radio frequency RF subsystem is equipped with an NMR spectrum analyzer which is connected to the data processing and display module.
  • the NMR spectrum analyzer has a transmission (Tx) and gate control (GATE) unidirectional signal path connected with a power amplifier, and is equipped with a transceiver
  • the conversion gate (T/R GATE) is connected to the transceiver switching module.
  • the power amplifier amplifies the transmission signal and connects to the transceiver switching module.
  • the transceiver switching module is used to switch the entire radio frequency subsystem in the transmitting state or the receiving state.
  • the radio frequency coil or radio frequency coil array is used to transmit radio frequency pulses; in the receiving state, the radio frequency coil is used to receive the magnetic resonance signal generated after the organ fat detection target site is excited, and the unilateral magnet module generates all the magnetic resonance signals.
  • the static magnetic field B 0 the NMR spectrometer is used to control the transmission and reception of the entire radio frequency subsystem, the preamplifier is used to amplify the received magnetic resonance signal, and is connected to the NMR spectrometer, and the magnetic After the resonance signal is collected by the radio frequency coil, it is transmitted back to the NMR spectrometer to store through the preamplifier, and the organ fat data is calculated by the data processing module, which constitutes the non-invasive quantitative detection of organ fat based on the principle of magnetic resonance system.
  • the magnet is made of rare earth permanent magnetic materials, has a small size and light weight, supports handheld or bracket mounting, and is convenient to adjust to a supine, prone, sitting or standing posture suitable for the subject.
  • one or more deep tissues under the skin of the human body can be selectively excited, or selectively excited and
  • one or more receiving coils with limited sensitive areas can be arranged as an array, and each receiving coil will only detect and receive signals in its sensitive area; combining these two The combination of these mechanisms can establish an independent area in the three-dimensional space of the human body for collecting magnetic resonance signals.
  • the invention discloses a non-invasive quantitative detection system for organ fat based on the principle of magnetic resonance, which reasonably solves the problem that the prior art organ fat detection adopts tissue slice biopsy, which is expensive, damaged, and is not suitable for early screening detection and conventional ultrasound imaging detection The problem of high subjectivity, poor reliability of results, and inability to achieve quantitative detection.
  • the invention adopts a radio frequency RF subsystem, a portable magnet module and a data processing and display module to jointly construct a low-field nuclear magnetic resonance system.
  • the low-field nuclear magnetic resonance system acts on the human body, there is no damage and no wound to organs, tissues and cells. Realize accurate, non-invasive, and safe quantitative detection of organ fat. It has the characteristics of being portable, cost-effective, and accurate quantification.
  • the operation is convenient and not restricted by the qualifications of the operators, and the "one-click" detection can be realized in a few minutes, which can be used to quickly and economically screen for NAFLD, metabolic syndrome, non-alcoholic steatohepatitis (NASH) and other related diseases, with a wide range of applications .
  • NAFLD nuclear RF subsystem
  • MASH non-alcoholic steatohepatitis
  • Figure 1 is a schematic diagram of the system architecture of the present invention.
  • Fig. 2 is a schematic diagram of the structure of the portable magnet module of the present invention.
  • Figure 3 is a schematic diagram of the magnetic field of the portable magnet module of the present invention.
  • Fig. 4 is a schematic diagram of the detection state of the portable magnet module of the present invention.
  • a non-invasive quantitative detection system for organ fat based on the principle of magnetic resonance including a portable magnet module, a radio frequency RF subsystem, a data processing and display module, is characterized by:
  • the portable magnet module is provided with a portable magnet, and the portable magnet setting method includes at least a small single-sided magnet, the portable magnet is set as an ergonomic curved surface that fits the body surface adjacent to the target sample organ, and the back is connected
  • a magnetic yoke is provided with a handle connected to the back of the magnetic yoke, and the portable magnet module generates a static magnetic field B 0 for polarizing hydrogen atoms in the region of interest (ROI) of the target sample.
  • the static magnetic field B 0 determines the precession frequency of hydrogen atoms under nuclear magnetic resonance conditions and the frequency corresponding to the radio frequency.
  • the field strength of B 0 allows large spatial changes within the ROI, and rapid attenuation outside the ROI to minimize safety and interference problem;
  • the radio frequency RF subsystem includes an NMR spectrometer, a power amplifier, a preamplifier, and one or more radio frequency coils.
  • the radio frequency coil generates a pulse vector magnetic field B 1 in a detection area, and the pulse vector magnetic field B 1 In the ROI, it should not be parallel to the static magnetic field B 0. If it is orthogonal, the efficiency is the highest.
  • the frequency of the pulse vector magnetic field B 1 is adjustable to match the Larmor frequency at different positions in the ROI.
  • the Larmor frequency is the 1 H gyromagnetic ratio multiplied by the B 0 field strength.
  • the radio frequency RF subsystem also includes an NMR spectrometer for controlling the transmitted radio frequency pulse vector magnetic field, which drives one or more of the radio frequency coils to excite The target detects the hydrogen atoms in the sample and generates a detectable signal, also known as a magnetic resonance signal or echo.
  • the NMR spectrometer is also used to control and receive the signals collected from one or more of the radio frequency coils and store them;
  • the data processing and display module includes at least one processor and a user interface programmed to calculate the proton density fat content based on the signal.
  • the user interface is used for the visualization of the organ fat ratio, displaying measurement confidence and other diagnostic information,
  • the system is also used to combine other patient-specific information from other tests, records or imaging studies for convenient comprehensive interpretation;
  • the organ fat non-invasive quantitative detection system is equipped with a radio frequency RF subsystem and a portable magnet module to construct a low-field nuclear magnetic resonance system, which does not damage organs, tissues and cells when the low-field nuclear magnetic resonance system acts on the human body.
  • the radio frequency RF subsystem is equipped with an NMR spectrum analyzer which is connected to the data processing and display module.
  • the NMR spectrum analyzer has a transmission (Tx) and gate control (GATE) unidirectional signal path connected with a power amplifier, and is equipped with a transceiver
  • the conversion gate (T/R GATE) is connected to the transceiver switching module.
  • the power amplifier amplifies the transmission signal and connects to the transceiver switching module.
  • the transceiver switching module is used to switch the entire radio frequency subsystem in the transmitting state or the receiving state.
  • the radio frequency coil or radio frequency coil array is used to transmit radio frequency pulses; in the receiving state, the radio frequency coil is used to receive the magnetic resonance signal generated after the organ fat detection target site is excited, and the unilateral magnet module generates all the magnetic resonance signals.
  • the static magnetic field B 0 the NMR spectrometer is used to control the transmission and reception of the entire radio frequency subsystem, the preamplifier is used to amplify the received magnetic resonance signal, and is connected to the NMR spectrometer, and the magnetic After the resonance signal is collected by the radio frequency coil, it is transmitted back to the NMR spectrometer to store through the preamplifier, and the organ fat data is calculated by the data processing module, which constitutes the non-invasive quantitative detection of organ fat based on the principle of magnetic resonance system.
  • the magnet is made of rare earth permanent magnetic materials, is small in size and light in weight, supports handheld or bracket mounting, and is convenient to adjust to a supine, prone, sitting or standing posture suitable for the subject.
  • one or more deep tissues under the skin of the human body can be selectively excited, or selectively excited and In the space of the two orthogonal directions in the depth direction, one or more receiving coils with limited sensitive areas can be arranged as an array, and each receiving coil will only detect and receive signals in its sensitive area; combining these two The combination of these mechanisms can establish an independent area in the three-dimensional space of the human body for collecting magnetic resonance signals.
  • the implementation of the non-invasive quantitative detection system for organ fat based on the principle of magnetic resonance is completed.

Abstract

Organ fat incisionless quantitative detection system based on the principles of magnetic resonance, with one radiofrequency (RF) subsystem, one portable magnetic module, and one data processing and displaying module jointly constituting one low-field nuclear magnetic resonance system. The low-field nuclear magnetic resonance system, when used on the human body, inflicts no damage to the organs, tissues, and cells and no incision. This implements accurate, non-invasive, safe organ fat quantitative detection, is characterized by being light and easily portable, a high cost-performance ratio, and accurate quantification; at the same time, is simple to operate and is not restrained by operator qualifications, implements "single-press" detection within a few minutes, is used for quick and economical screening of related diseases such as NAFLD, metabolic syndrome, non-alcoholic steatohepatitis, has a wide range of applications, and overcomes a shortcoming of the prior art.

Description

一种基于磁共振原理的器官脂肪无创定量检测系统A non-invasive quantitative detection system for organ fat based on the principle of magnetic resonance 技术领域Technical field
本发明涉及一种核磁共振医学检测技术领域，尤其涉及一种基于磁共振原理的器官脂肪无创定量检测系统。The invention relates to the technical field of nuclear magnetic resonance medical detection, in particular to a non-invasive quantitative detection system for organ fat based on the principle of magnetic resonance.
背景技术Background technique
全球约25％的人口被怀疑患有非酒精性脂肪肝(NAFLD)，由于缺乏可行、现实和准确的早期检测和监测方法，许多人仍未得到诊断。现有技术诊断NAFLD的金标准采用肝组织活检，不仅费用昂贵而且有创，不适合用于早期检测。常规超声成像应用广泛，但仅能提供定性信息，对操作者依赖性强。此外，在NAFLD患者中常见肥胖和皮下脂肪过多病例，超声检查很难获得可靠的结果。常规MRI是一种新兴的NAFLD状态监测技术，已被广泛接受，但由于成本高，在常规临床检测中普遍适用性不强。About 25% of the global population is suspected of having non-alcoholic fatty liver disease (NAFLD). Due to the lack of feasible, realistic and accurate early detection and monitoring methods, many people have not yet been diagnosed. The gold standard for diagnosis of NAFLD in the prior art uses liver biopsy, which is expensive and invasive, and is not suitable for early detection. Conventional ultrasound imaging is widely used, but it can only provide qualitative information and is highly dependent on the operator. In addition, obesity and excess subcutaneous fat are common in NAFLD patients, and it is difficult to obtain reliable results from ultrasound examination. Conventional MRI is an emerging NAFLD status monitoring technology, which has been widely accepted, but due to its high cost, it is generally not applicable in routine clinical testing.
本发明采用设有一个射频RF子系统，一个便携式磁体模块和一个数据处理和显示模块共同建构一个低场核磁共振系统。所述低场核磁共振系统作用于人体时对器官、组织和细胞无损伤、无创口。实现准确、非侵入性、安全的器官脂肪定量检测，具有轻便易携带、性价比高、精准定量等特点。同时操作便捷不受操作人员资质约束，数分钟内实现“一键”检测，用于快速、经济地筛查NAFLD、代谢综合征、非酒精性脂肪性肝炎(NASH)等相关疾病，适用范围广泛。克服了现有技术的不足。The invention adopts a radio frequency RF subsystem, a portable magnet module and a data processing and display module to jointly construct a low-field nuclear magnetic resonance system. When the low-field nuclear magnetic resonance system acts on the human body, there is no damage and no wound to organs, tissues and cells. Realize accurate, non-invasive, and safe quantitative detection of organ fat. It has the characteristics of being portable, cost-effective, and accurate quantification. At the same time, the operation is convenient and not restricted by the qualifications of the operators, and the "one-click" detection can be realized in a few minutes, which can be used to quickly and economically screen for NAFLD, metabolic syndrome, non-alcoholic steatohepatitis (NASH) and other related diseases, with a wide range of applications . Overcome the shortcomings of the existing technology.
发明内容Summary of the invention
本发明的目的在于提供一种基于磁共振原理的器官脂肪无创定量检测系统，合理地解决了现有技术的器官脂肪检测采用组织切片活检费用 高、损伤大、不适用早期筛查检测和常规超声成像检测主观性大、结果可靠性差、不能实现定量检测的问题。The purpose of the present invention is to provide a non-invasive quantitative detection system for organ fat based on the principle of magnetic resonance, which reasonably solves the problem that the prior art organ fat detection adopts tissue slice biopsy, which is expensive and damaged, and is not suitable for early screening detection and conventional ultrasound. Imaging detection is subjective, the reliability of the results is poor, and quantitative detection cannot be achieved.
本发明采用如下技术方案：The present invention adopts the following technical solutions:
一种基于磁共振原理的器官脂肪无创定量检测系统，包括便携式磁体模块、射频RF子系统、数据处理和显示模块，其特征在于：A non-invasive quantitative detection system for organ fat based on the principle of magnetic resonance, including a portable magnet module, a radio frequency RF subsystem, a data processing and display module, and is characterized by:
所述便携式磁体模块设有便携式磁体，所述便携式磁体设置方式至少包括小型单边磁体，所述便携式磁体设置为与目标检样器官相邻的身体表面贴合的人体工程学弧曲面，背面连接设有磁轭，所述磁轭的背面连接设有手柄，所述便携式磁体模块产生一个静态磁场B 0，用于极化目标检样的感兴趣区域(ROI)的氢原子，所述静态磁场B 0确定了核磁共振条件下氢原子的进动频率以及射频场所对应的频率B 0场强度在ROI内允许有较大的空间变化，在ROI外则快速衰减，以最大限度降低安全性及干扰问题； The portable magnet module is provided with a portable magnet, and the portable magnet setting method includes at least a small single-sided magnet, the portable magnet is set as an ergonomic curved surface that fits the body surface adjacent to the target sample organ, and the back is connected A magnetic yoke is provided with a handle connected to the back of the magnetic yoke, and the portable magnet module generates a static magnetic field B 0 for polarizing hydrogen atoms in the region of interest (ROI) of the target sample. The static magnetic field B 0 determines the precession frequency of hydrogen atoms under nuclear magnetic resonance conditions and the frequency corresponding to the radio frequency. The field strength of B 0 allows large spatial changes within the ROI, and rapid attenuation outside the ROI to minimize safety and interference problem;
所述射频RF子系统包括一个NMR频谱仪、一个功率放大器、一个前置放大器、一个或多个射频线圈，所述射频线圈在检测区域内产生脉冲向量磁场B 1，所述脉冲向量磁场B 1在所述ROI内不应与所述静态磁场B 0平行，若正交则效率最高，所述脉冲向量磁场B 1的频率是可调的，用以匹配ROI内不同位置的Larmor频率，所述Larmor频率为 1H旋磁比乘以B 0场强，所述射频RF子系统还包括一个NMR频谱仪，用于控制发射射频脉冲向量磁场，它驱动一个或多个所述射频线圈，以激发目标检样中的氢原子并产生可检测信号，又称磁共振信号或回波，NMR频谱仪还用于控制接收从一个或多个所述射频线圈收集到的信号，并存储下来； The radio frequency RF subsystem includes an NMR spectrometer, a power amplifier, a preamplifier, and one or more radio frequency coils. The radio frequency coil generates a pulse vector magnetic field B 1 in a detection area, and the pulse vector magnetic field B 1 In the ROI, it should not be parallel to the static magnetic field B 0. If it is orthogonal, the efficiency is the highest. The frequency of the pulse vector magnetic field B 1 is adjustable to match the Larmor frequency at different positions in the ROI. The Larmor frequency is the 1 H gyromagnetic ratio multiplied by the B 0 field strength. The radio frequency RF subsystem also includes an NMR spectrometer for controlling the transmitted radio frequency pulse vector magnetic field, which drives one or more of the radio frequency coils to excite The target detects the hydrogen atoms in the sample and generates a detectable signal, also known as a magnetic resonance signal or echo. The NMR spectrometer is also used to control and receive the signals collected from one or more of the radio frequency coils and store them;
数据处理和显示模块包括至少一个处理器和一个用户界面，该处理器被编程来根据信号计算质子密度脂肪含量，所述用户界面用于器官脂肪比例的可视化，显示测量置信度和其他诊断信息，该系统还用来结合 来自其他测试、记录或成像研究的其他患者特定信息，以便进行方便的综合解释；The data processing and display module includes at least one processor and a user interface programmed to calculate the proton density fat content based on the signal. The user interface is used for the visualization of the organ fat ratio, displaying measurement confidence and other diagnostic information, The system is also used to combine other patient-specific information from other tests, records or imaging studies for convenient comprehensive interpretation;
所述器官脂肪无创定量检测系统设有一个射频RF子系统和一个便携式磁体模块建构一个低场核磁共振系统，所述低场核磁共振系统作用于人体时对器官、组织和细胞无损伤，所述射频RF子系统设有一台NMR频谱仪与所述数据处理和显示模块数据连接，NMR频谱仪设有发射(Tx)和门控(GATE)单向信号通路与一台功率放大器连接，设有收发转换门控(T/R GATE)与收发切换模块连接，所述功率放大器将发射信号放大后与收发切换模块连接，所述收发切换模块用于切换整个射频子系统处于发射状态或接收状态，发射状态下，所述射频线圈或射频线圈阵列用于发射射频脉冲；接收状态下，所述射频线圈用于接收器官脂肪检测靶位受激发后产生的磁共振信号，所述单边磁体模块产生所述静态磁场B 0，所述NMR频谱仪用于控制整个射频子系统的发射和接收，所述前置放大器用于放大接收到的磁共振信号，并与所述NMR频谱仪连接，所述磁共振信号由所述射频线圈采集后，经所述前置放大器传回所述NMR频谱仪存储，并经数据处理模块算出器官脂肪数据，构成所述一种基于磁共振原理的器官脂肪无创定量检测系统。 The organ fat non-invasive quantitative detection system is equipped with a radio frequency RF subsystem and a portable magnet module to construct a low-field nuclear magnetic resonance system, which does not damage organs, tissues and cells when the low-field nuclear magnetic resonance system acts on the human body. The radio frequency RF subsystem is equipped with an NMR spectrum analyzer which is connected to the data processing and display module. The NMR spectrum analyzer has a transmission (Tx) and gate control (GATE) unidirectional signal path connected with a power amplifier, and is equipped with a transceiver The conversion gate (T/R GATE) is connected to the transceiver switching module. The power amplifier amplifies the transmission signal and connects to the transceiver switching module. The transceiver switching module is used to switch the entire radio frequency subsystem in the transmitting state or the receiving state. In the state, the radio frequency coil or radio frequency coil array is used to transmit radio frequency pulses; in the receiving state, the radio frequency coil is used to receive the magnetic resonance signal generated after the organ fat detection target site is excited, and the unilateral magnet module generates all the magnetic resonance signals. The static magnetic field B 0 , the NMR spectrometer is used to control the transmission and reception of the entire radio frequency subsystem, the preamplifier is used to amplify the received magnetic resonance signal, and is connected to the NMR spectrometer, and the magnetic After the resonance signal is collected by the radio frequency coil, it is transmitted back to the NMR spectrometer to store through the preamplifier, and the organ fat data is calculated by the data processing module, which constitutes the non-invasive quantitative detection of organ fat based on the principle of magnetic resonance system.
进一步地，所述磁体由稀土永久磁性材料构成，体积小、重量轻，支持手持或支架挂载，便于调整到适合受检者的仰卧、俯卧、坐姿或站姿体位。Further, the magnet is made of rare earth permanent magnetic materials, has a small size and light weight, supports handheld or bracket mounting, and is convenient to adjust to a supine, prone, sitting or standing posture suitable for the subject.
进一步地，通过控制发射射频频率匹配和设计接收线圈空间灵敏度，在垂直于磁体内表面的深度方向，采用选择性地激发人体皮肤下的一个或多个深度的组织，或采用选择性地激发与所述深度方向正交的两个方向的空间，一个或多个具有有限的敏感区域的接收线圈能够设置为一个阵列，每个接收线圈将只检测和接收其敏感区域内的信号；将这两种机 制结合起来，能够在人体的三维空间中建立一个独立的区域，用于采集磁共振信号。Further, by controlling the frequency matching of the transmitting radio frequency and designing the spatial sensitivity of the receiving coil, in the depth direction perpendicular to the inner surface of the magnet, one or more deep tissues under the skin of the human body can be selectively excited, or selectively excited and In the space of the two orthogonal directions in the depth direction, one or more receiving coils with limited sensitive areas can be arranged as an array, and each receiving coil will only detect and receive signals in its sensitive area; combining these two The combination of these mechanisms can establish an independent area in the three-dimensional space of the human body for collecting magnetic resonance signals.
本发明的有益技术效果是：The beneficial technical effects of the present invention are:
本发明公开了一种基于磁共振原理的器官脂肪无创定量检测系统，合理地解决了现有技术的器官脂肪检测采用组织切片活检费用高、损伤大、不适用早期筛查检测和常规超声成像检测主观性大、结果可靠性差、不能实现定量检测的问题。The invention discloses a non-invasive quantitative detection system for organ fat based on the principle of magnetic resonance, which reasonably solves the problem that the prior art organ fat detection adopts tissue slice biopsy, which is expensive, damaged, and is not suitable for early screening detection and conventional ultrasound imaging detection The problem of high subjectivity, poor reliability of results, and inability to achieve quantitative detection.
本发明采用设有一个射频RF子系统，一个便携式磁体模块和一个数据处理和显示模块共同建构一个低场核磁共振系统。所述低场核磁共振系统作用于人体时对器官、组织和细胞无损伤、无创口。实现准确、非侵入性、安全的器官脂肪定量检测，具有轻便易携带、性价比高、精准定量等特点。同时操作便捷不受操作人员资质约束，数分钟内实现“一键”检测，用于快速、经济地筛查NAFLD、代谢综合征、非酒精性脂肪性肝炎(NASH)等相关疾病，适用范围广泛。克服了现有技术的不足。The invention adopts a radio frequency RF subsystem, a portable magnet module and a data processing and display module to jointly construct a low-field nuclear magnetic resonance system. When the low-field nuclear magnetic resonance system acts on the human body, there is no damage and no wound to organs, tissues and cells. Realize accurate, non-invasive, and safe quantitative detection of organ fat. It has the characteristics of being portable, cost-effective, and accurate quantification. At the same time, the operation is convenient and not restricted by the qualifications of the operators, and the "one-click" detection can be realized in a few minutes, which can be used to quickly and economically screen for NAFLD, metabolic syndrome, non-alcoholic steatohepatitis (NASH) and other related diseases, with a wide range of applications . Overcome the shortcomings of the existing technology.
附图说明Description of the drawings
图1是本发明系统架构示意图。Figure 1 is a schematic diagram of the system architecture of the present invention.
图2是本发明便携式磁体模块结构示意图。Fig. 2 is a schematic diagram of the structure of the portable magnet module of the present invention.
图3是本发明便携式磁体模块磁场示意图。Figure 3 is a schematic diagram of the magnetic field of the portable magnet module of the present invention.
图4是本发明便携式磁体模块检测状态示意图。Fig. 4 is a schematic diagram of the detection state of the portable magnet module of the present invention.
图中所示：1-便携式磁体、2-人体工程学弧曲面、3-磁轭、4-手柄、5-感兴趣区域(ROI)、6-射频线圈。Shown in the picture: 1-portable magnet, 2-ergonomic arc surface, 3- yoke, 4- handle, 5- region of interest (ROI), 6-RF coil.
具体实施方式Detailed ways
通过下面对实施例的描述，将更加有助于公众理解本发明，但不能也不应当将申请人所给出的具体的实施例视为对本发明技术方案的限制， 任何对部件或技术特征的定义进行改变和/或对整体结构作形式的而非实质的变换都应视为本发明的技术方案所限定的保护范围。Through the following description of the embodiments, it will be more helpful for the public to understand the present invention, but the specific embodiments given by the applicant cannot and should not be regarded as limitations on the technical solutions of the present invention, and any components or technical features Any change to the definition of and/or a formal but not substantial change to the overall structure should be regarded as the protection scope defined by the technical solution of the present invention.
实施例Example
如图1-4所示一种基于磁共振原理的器官脂肪无创定量检测系统，包括便携式磁体模块、射频RF子系统、数据处理和显示模块，其特征在于：As shown in Figure 1-4, a non-invasive quantitative detection system for organ fat based on the principle of magnetic resonance, including a portable magnet module, a radio frequency RF subsystem, a data processing and display module, is characterized by:
所述便携式磁体模块设有便携式磁体，所述便携式磁体设置方式至少包括小型单边磁体，所述便携式磁体设置为与目标检样器官相邻的身体表面贴合的人体工程学弧曲面，背面连接设有磁轭，所述磁轭的背面连接设有手柄，所述便携式磁体模块产生一个静态磁场B 0，用于极化目标检样的感兴趣区域(ROI)的氢原子，所述静态磁场B 0确定了核磁共振条件下氢原子的进动频率以及射频场所对应的频率B 0场强度在ROI内允许有较大的空间变化，在ROI外则快速衰减，以最大限度降低安全性及干扰问题； The portable magnet module is provided with a portable magnet, and the portable magnet setting method includes at least a small single-sided magnet, the portable magnet is set as an ergonomic curved surface that fits the body surface adjacent to the target sample organ, and the back is connected A magnetic yoke is provided with a handle connected to the back of the magnetic yoke, and the portable magnet module generates a static magnetic field B 0 for polarizing hydrogen atoms in the region of interest (ROI) of the target sample. The static magnetic field B 0 determines the precession frequency of hydrogen atoms under nuclear magnetic resonance conditions and the frequency corresponding to the radio frequency. The field strength of B 0 allows large spatial changes within the ROI, and rapid attenuation outside the ROI to minimize safety and interference problem;
所述射频RF子系统包括一个NMR频谱仪、一个功率放大器、一个前置放大器、一个或多个射频线圈，所述射频线圈在检测区域内产生脉冲向量磁场B 1，所述脉冲向量磁场B 1在所述ROI内不应与所述静态磁场B 0平行，若正交则效率最高，所述脉冲向量磁场B 1的频率是可调的，用以匹配ROI内不同位置的Larmor频率，所述Larmor频率为 1H旋磁比乘以B 0场强，所述射频RF子系统还包括一个NMR频谱仪，用于控制发射射频脉冲向量磁场，它驱动一个或多个所述射频线圈，以激发目标检样中的氢原子并产生可检测信号，又称磁共振信号或回波，NMR频谱仪还用于控制接收从一个或多个所述射频线圈收集到的信号，并存储下来； The radio frequency RF subsystem includes an NMR spectrometer, a power amplifier, a preamplifier, and one or more radio frequency coils. The radio frequency coil generates a pulse vector magnetic field B 1 in a detection area, and the pulse vector magnetic field B 1 In the ROI, it should not be parallel to the static magnetic field B 0. If it is orthogonal, the efficiency is the highest. The frequency of the pulse vector magnetic field B 1 is adjustable to match the Larmor frequency at different positions in the ROI. The Larmor frequency is the 1 H gyromagnetic ratio multiplied by the B 0 field strength. The radio frequency RF subsystem also includes an NMR spectrometer for controlling the transmitted radio frequency pulse vector magnetic field, which drives one or more of the radio frequency coils to excite The target detects the hydrogen atoms in the sample and generates a detectable signal, also known as a magnetic resonance signal or echo. The NMR spectrometer is also used to control and receive the signals collected from one or more of the radio frequency coils and store them;
数据处理和显示模块包括至少一个处理器和一个用户界面，该处理器被编程来根据信号计算质子密度脂肪含量，所述用户界面用于器官脂肪比例的可视化，显示测量置信度和其他诊断信息，该系统还用来结合 来自其他测试、记录或成像研究的其他患者特定信息，以便进行方便的综合解释；The data processing and display module includes at least one processor and a user interface programmed to calculate the proton density fat content based on the signal. The user interface is used for the visualization of the organ fat ratio, displaying measurement confidence and other diagnostic information, The system is also used to combine other patient-specific information from other tests, records or imaging studies for convenient comprehensive interpretation;
所述器官脂肪无创定量检测系统设有一个射频RF子系统和一个便携式磁体模块建构一个低场核磁共振系统，所述低场核磁共振系统作用于人体时对器官、组织和细胞无损伤，所述射频RF子系统设有一台NMR频谱仪与所述数据处理和显示模块数据连接，NMR频谱仪设有发射(Tx)和门控(GATE)单向信号通路与一台功率放大器连接，设有收发转换门控(T/R GATE)与收发切换模块连接，所述功率放大器将发射信号放大后与收发切换模块连接，所述收发切换模块用于切换整个射频子系统处于发射状态或接收状态，发射状态下，所述射频线圈或射频线圈阵列用于发射射频脉冲；接收状态下，所述射频线圈用于接收器官脂肪检测靶位受激发后产生的磁共振信号，所述单边磁体模块产生所述静态磁场B 0，所述NMR频谱仪用于控制整个射频子系统的发射和接收，所述前置放大器用于放大接收到的磁共振信号，并与所述NMR频谱仪连接，所述磁共振信号由所述射频线圈采集后，经所述前置放大器传回所述NMR频谱仪存储，并经数据处理模块算出器官脂肪数据，构成所述一种基于磁共振原理的器官脂肪无创定量检测系统。 The organ fat non-invasive quantitative detection system is equipped with a radio frequency RF subsystem and a portable magnet module to construct a low-field nuclear magnetic resonance system, which does not damage organs, tissues and cells when the low-field nuclear magnetic resonance system acts on the human body. The radio frequency RF subsystem is equipped with an NMR spectrum analyzer which is connected to the data processing and display module. The NMR spectrum analyzer has a transmission (Tx) and gate control (GATE) unidirectional signal path connected with a power amplifier, and is equipped with a transceiver The conversion gate (T/R GATE) is connected to the transceiver switching module. The power amplifier amplifies the transmission signal and connects to the transceiver switching module. The transceiver switching module is used to switch the entire radio frequency subsystem in the transmitting state or the receiving state. In the state, the radio frequency coil or radio frequency coil array is used to transmit radio frequency pulses; in the receiving state, the radio frequency coil is used to receive the magnetic resonance signal generated after the organ fat detection target site is excited, and the unilateral magnet module generates all the magnetic resonance signals. The static magnetic field B 0 , the NMR spectrometer is used to control the transmission and reception of the entire radio frequency subsystem, the preamplifier is used to amplify the received magnetic resonance signal, and is connected to the NMR spectrometer, and the magnetic After the resonance signal is collected by the radio frequency coil, it is transmitted back to the NMR spectrometer to store through the preamplifier, and the organ fat data is calculated by the data processing module, which constitutes the non-invasive quantitative detection of organ fat based on the principle of magnetic resonance system.
进一步地，所述磁体由稀土永久磁性材料构成，体积小、重量轻，支持手持或支架挂载，便于调整到适合受检者的仰卧、俯卧、坐姿或站姿体位。Further, the magnet is made of rare earth permanent magnetic materials, is small in size and light in weight, supports handheld or bracket mounting, and is convenient to adjust to a supine, prone, sitting or standing posture suitable for the subject.
进一步地，通过控制发射射频频率匹配和设计接收线圈空间灵敏度，在垂直于磁体内表面的深度方向，采用选择性地激发人体皮肤下的一个或多个深度的组织，或采用选择性地激发与所述深度方向正交的两个方向的空间，一个或多个具有有限的敏感区域的接收线圈能够设置为一个阵列，每个接收线圈将只检测和接收其敏感区域内的信号；将这两种机制 结合起来，能够在人体的三维空间中建立一个独立的区域，用于采集磁共振信号。完成所述一种基于磁共振原理的器官脂肪无创定量检测系统的实施。Further, by controlling the frequency matching of the transmitting radio frequency and designing the spatial sensitivity of the receiving coil, in the depth direction perpendicular to the inner surface of the magnet, one or more deep tissues under the skin of the human body can be selectively excited, or selectively excited and In the space of the two orthogonal directions in the depth direction, one or more receiving coils with limited sensitive areas can be arranged as an array, and each receiving coil will only detect and receive signals in its sensitive area; combining these two The combination of these mechanisms can establish an independent area in the three-dimensional space of the human body for collecting magnetic resonance signals. The implementation of the non-invasive quantitative detection system for organ fat based on the principle of magnetic resonance is completed.
当然，本发明还可以有其他多种实施例，在不背离本发明精神及其实质的情况下，熟悉本领域的技术人员可以根据本发明做出各种相应的改变和变形，但这些相应的改变和变形都应属于本发明所附的权利要求的保护范围。Of course, the present invention can also have various other embodiments. Without departing from the spirit and essence of the present invention, those skilled in the art can make various corresponding changes and modifications according to the present invention, but these corresponding All changes and deformations shall belong to the protection scope of the appended claims of the present invention.

Claims (3)

  1. 一种基于磁共振原理的器官脂肪无创定量检测系统，包括便携式磁体模块、射频RF子系统、数据处理和显示模块，其特征在于：A non-invasive quantitative detection system for organ fat based on the principle of magnetic resonance, including a portable magnet module, a radio frequency RF subsystem, a data processing and display module, and is characterized by:
    所述便携式磁体模块设有便携式磁体，所述便携式磁体设置方式至少包括小型单边磁体，所述便携式磁体设置为与目标检样器官相邻的身体表面贴合的人体工程学弧曲面，背面连接设有磁轭，所述磁轭的背面连接设有手柄，所述便携式磁体模块产生一个静态磁场B 0，用于极化目标检样的感兴趣区域(ROI)的氢原子，所述静态磁场B 0确定了核磁共振条件下氢原子的进动频率以及射频场所对应的频率B 0场强度在ROI内允许有较大的空间变化，在ROI外则快速衰减，以最大限度降低安全性及干扰问题； The portable magnet module is provided with a portable magnet, and the portable magnet setting method includes at least a small single-sided magnet, the portable magnet is set as an ergonomic curved surface that fits the body surface adjacent to the target sample organ, and the back is connected A magnetic yoke is provided with a handle connected to the back of the magnetic yoke, and the portable magnet module generates a static magnetic field B 0 for polarizing hydrogen atoms in the region of interest (ROI) of the target sample. The static magnetic field B 0 determines the precession frequency of hydrogen atoms under nuclear magnetic resonance conditions and the frequency corresponding to the radio frequency. The field strength of B 0 allows large spatial changes within the ROI, and rapid attenuation outside the ROI to minimize safety and interference problem;
    所述射频RF子系统包括一个NMR频谱仪、一个功率放大器、一个前置放大器、一个或多个射频线圈，所述射频线圈在检测区域内产生脉冲向量磁场B 1，所述脉冲向量磁场B 1在所述ROI内不应与所述静态磁场B 0平行，若正交则效率最高，所述脉冲向量磁场B 1的频率是可调的，用以匹配ROI内不同位置的Larmor频率，所述Larmor频率为 1H旋磁比乘以B 0场强，所述射频RF子系统还包括一个NMR频谱仪，用于控制发射射频脉冲向量磁场，它驱动一个或多个所述射频线圈，以激发目标检样中的氢原子并产生可检测信号，又称磁共振信号或回波，NMR频谱仪还用于控制接收从一个或多个所述射频线圈收集到的信号，并存储下来； The radio frequency RF subsystem includes an NMR spectrometer, a power amplifier, a preamplifier, and one or more radio frequency coils. The radio frequency coil generates a pulse vector magnetic field B 1 in a detection area, and the pulse vector magnetic field B 1 In the ROI, it should not be parallel to the static magnetic field B 0. If it is orthogonal, the efficiency is the highest. The frequency of the pulse vector magnetic field B 1 is adjustable to match the Larmor frequency at different positions in the ROI. The Larmor frequency is the 1 H gyromagnetic ratio multiplied by the B 0 field strength. The radio frequency RF subsystem also includes an NMR spectrometer for controlling the transmitted radio frequency pulse vector magnetic field, which drives one or more of the radio frequency coils to excite The target detects the hydrogen atoms in the sample and generates a detectable signal, also known as a magnetic resonance signal or echo. The NMR spectrometer is also used to control and receive the signals collected from one or more of the radio frequency coils and store them;
    数据处理和显示模块包括至少一个处理器和一个用户界面，该处理器被编程来根据信号计算质子密度脂肪含量，所述用户界面用于器官脂肪比例的可视化，显示测量置信度和其他诊断信息，该系统还用来结合来自其他测试、记录或成像研究的其他患者特定信息，以便进行方便的综合解释；The data processing and display module includes at least one processor and a user interface programmed to calculate the proton density fat content based on the signal. The user interface is used to visualize the fat ratio of the organ, display measurement confidence and other diagnostic information, The system is also used to combine other patient-specific information from other tests, records or imaging studies for convenient comprehensive interpretation;
    所述器官脂肪无创定量检测系统设有一个射频RF子系统和一个便携式磁体模块建构一个低场核磁共振系统，所述低场核磁共振系统作用于人体时对器官、组织和细胞无损伤，所述射频RF子系统设有一台NMR频谱仪与所述数据处理和显示模块数据连接，NMR频谱仪设有发射(Tx)和门控(GATE)单向信号通路与一台功率放大器连接，设有收发转换门控(T/R GATE)与收发切换模块连接，所述功率放大器将发射信号放大后与收发切换模块连接，所述收发切换模块用于切换整个射频子系统处于发射状态或接收状态，发射状态下，所述射频线圈或射频线圈阵列用于发射射频脉冲；接收状态下，所述射频线圈用于接收器官脂肪检测靶位受激发后产生的磁共振信号，所述单边磁体模块产生所述静态磁场B 0，所述NMR频谱仪用于控制整个射频子系统的发射和接收，所述前置放大器用于放大接收到的磁共振信号，并与所述NMR频谱仪连接，所述磁共振信号由所述射频线圈采集后，经所述前置放大器传回所述NMR频谱仪存储，并经数据处理模块算出器官脂肪数据，构成所述一种基于磁共振原理的器官脂肪无创定量检测系统。 The organ fat non-invasive quantitative detection system is equipped with a radio frequency RF subsystem and a portable magnet module to construct a low-field nuclear magnetic resonance system, which does not damage organs, tissues and cells when the low-field nuclear magnetic resonance system acts on the human body. The radio frequency RF subsystem is equipped with an NMR spectrum analyzer which is connected to the data processing and display module. The NMR spectrum analyzer has a transmission (Tx) and gate control (GATE) unidirectional signal path connected with a power amplifier, and is equipped with a transceiver The conversion gate (T/R GATE) is connected to the transceiver switching module. The power amplifier amplifies the transmission signal and connects to the transceiver switching module. The transceiver switching module is used to switch the entire radio frequency subsystem in the transmitting state or the receiving state. In the state, the radio frequency coil or radio frequency coil array is used to transmit radio frequency pulses; in the receiving state, the radio frequency coil is used to receive the magnetic resonance signal generated after the organ fat detection target site is excited, and the unilateral magnet module generates all the magnetic resonance signals. The static magnetic field B 0 , the NMR spectrometer is used to control the transmission and reception of the entire radio frequency subsystem, the preamplifier is used to amplify the received magnetic resonance signal, and is connected to the NMR spectrometer, and the magnetic After the resonance signal is collected by the radio frequency coil, it is transmitted back to the NMR spectrometer to store through the preamplifier, and the organ fat data is calculated by the data processing module, which constitutes the non-invasive quantitative detection of organ fat based on the principle of magnetic resonance system.
  2. 根据权利要求1所述一种基于磁共振原理的器官脂肪无创定量检测系统，其特征在于，所述磁体由稀土永久磁性材料构成，体积小、重量轻，支持手持或支架挂载，便于调整到适合受检者的仰卧、俯卧、坐姿或站姿体位。The non-invasive quantitative detection system for organ fat based on the principle of magnetic resonance according to claim 1, characterized in that the magnet is made of rare earth permanent magnetic material, is small in size and light in weight, supports handheld or bracket mounting, and is easy to adjust to Suitable for the subject's supine, prone, sitting or standing posture.
  3. 根据权利要求1所述一种基于磁共振原理的器官脂肪无创定量检测系统，其特征在于，通过控制发射射频频率匹配和设计接收线圈空间灵敏度，在垂直于磁体内表面的深度方向，采用选择性地激发人体皮肤下的一个或多个深度的组织，或采用选择性地激发与所述深度方向正交的两个方向的空间，一个或多个具有有限的敏感区域的接收线圈能够设置为一个阵列，每个接收线圈将只检测和接收其敏感区域内的信号；将这两 种机制结合起来，能够在人体的三维空间中建立一个独立的区域，用于采集磁共振信号。The non-invasive quantitative detection system of organ fat based on the principle of magnetic resonance according to claim 1, characterized in that by controlling the transmission radio frequency matching and designing the spatial sensitivity of the receiving coil, the selective method is adopted in the depth direction perpendicular to the inner surface of the magnet. Groundly excite one or more deep tissues under the human skin, or selectively excite the space in two directions orthogonal to the depth direction, one or more receiving coils with limited sensitive areas can be set as one In the array, each receiving coil will only detect and receive signals in its sensitive area; combining these two mechanisms can establish an independent area in the three-dimensional space of the human body for collecting magnetic resonance signals.
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