WO2021081846A1 - Procédé de traitement d'image de tumeur veineuse et produit associé - Google Patents

Procédé de traitement d'image de tumeur veineuse et produit associé Download PDF

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Publication number
WO2021081846A1
WO2021081846A1 PCT/CN2019/114487 CN2019114487W WO2021081846A1 WO 2021081846 A1 WO2021081846 A1 WO 2021081846A1 CN 2019114487 W CN2019114487 W CN 2019114487W WO 2021081846 A1 WO2021081846 A1 WO 2021081846A1
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WIPO (PCT)
Prior art keywords
venous
image data
data
blood vessels
venous blood
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PCT/CN2019/114487
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English (en)
Chinese (zh)
Inventor
李戴维伟
李斯图尔特平
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未艾医疗技术(深圳)有限公司
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Priority to PCT/CN2019/114487 priority Critical patent/WO2021081846A1/fr
Priority to CN201980100002.9A priority patent/CN114375438A/zh
Publication of WO2021081846A1 publication Critical patent/WO2021081846A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F3/00—Input arrangements for transferring data to be processed into a form capable of being handled by the computer; Output arrangements for transferring data from processing unit to output unit, e.g. interface arrangements
    • G06F3/01—Input arrangements or combined input and output arrangements for interaction between user and computer
    • G06F3/048—Interaction techniques based on graphical user interfaces [GUI]
    • G06F3/0487—Interaction techniques based on graphical user interfaces [GUI] using specific features provided by the input device, e.g. functions controlled by the rotation of a mouse with dual sensing arrangements, or of the nature of the input device, e.g. tap gestures based on pressure sensed by a digitiser
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T15/00—3D [Three Dimensional] image rendering

Definitions

  • This application relates to the technical field of medical imaging devices, in particular to a venous vascular tumor image processing method and related products.
  • CT Computer Tomography
  • MRI Magnetic Resonance Imaging
  • DTI Diffusion Tensor Imaging
  • PET PET
  • CT Computed Tomography
  • the embodiments of the application provide a venous vascular tumor image processing method and related products, which are beneficial to improve the efficiency of disease analysis.
  • an embodiment of the present application provides a venous vascular tumor image processing method, which is applied to a medical imaging device, and includes:
  • the treatment device is controlled to perform surgery according to the 4D image data and the target position.
  • an embodiment of the present application provides a venous vascular tumor image processing device, which is applied to a medical imaging device, and the device includes:
  • the acquiring unit is used to acquire the scanned image of the target part of the target subject with venous vascular tumor through VRDS 4D imaging technology;
  • a processing unit configured to generate 4D image data of multiple venous vessels of the target part according to the scanned image
  • a determining unit configured to determine the target position of the venous blood vessel tumor in the multiple venous blood vessels according to the 4D image data of the multiple venous blood vessels;
  • An output unit for outputting the 4D image data and the target position
  • the control unit is used for controlling the treatment device to perform surgery according to the 4D image data and the target position.
  • an embodiment of the present application provides an electronic device, including a processor, a memory, a communication interface, and one or more programs, wherein the one or more programs are stored in the memory and configured by The foregoing processor executes, and the foregoing program includes instructions for executing the steps in the first aspect of the embodiments of the present application.
  • an embodiment of the present application provides a computer-readable storage medium, wherein the above-mentioned computer-readable storage medium stores a computer program for electronic data exchange, wherein the above-mentioned computer program enables a computer to execute Some or all of the steps described in one aspect.
  • the embodiments of the present application provide a computer program product, wherein the computer program product includes a non-transitory computer-readable storage medium storing a computer program, and the computer program is operable to cause a computer to execute as implemented in this application.
  • the computer program product may be a software installation package.
  • FIG. 1 is a schematic structural diagram of a venous vascular tumor imaging processing system provided by an embodiment of the application;
  • FIG. 2A is a schematic flowchart of a method for processing venous vascular tumor imaging according to an embodiment of the application
  • 2B is a schematic structural diagram of a treatment device provided by an embodiment of the application.
  • 2C is a partial schematic diagram of skin venous vascular tumor treatment through the puncture site of the treatment device according to an embodiment of the application;
  • 2D is a partial schematic diagram of another skin venous vascular tumor treatment through the puncture site of the treatment device according to an embodiment of the application;
  • Fig. 2E is a partial schematic diagram of still another skin venous vascular tumor treatment through the puncture site of the treatment device according to an embodiment of the application;
  • 2F is another partial schematic diagram of skin venous vascular tumor treatment through the puncture site of the treatment device provided by the embodiment of the application;
  • FIG. 3 is a schematic structural diagram of a medical imaging device provided by an embodiment of the application.
  • FIG. 4 is a schematic structural diagram of a venous tumor image processing device provided by an embodiment of the application.
  • the medical imaging devices involved in the embodiments of this application refer to various instruments that use various media as information carriers to reproduce the internal structure of the human body as images.
  • the image information and the actual structure of the human body have spatial and temporal distributions.
  • DICOM data refers to the original image file data that reflects the internal structural characteristics of the human body collected by medical equipment, which can include electronic computed tomography CT, magnetic resonance MRI, diffusion tensor imaging DTI, and positron emission computed tomography PET-
  • image source refers to the Texture2D/3D image volume data generated by analyzing the original DICOM data.
  • VRDS refers to the Virtual Reality Doctor system (VRDS for short).
  • FIG. 1 is a schematic structural diagram of a venous vascular tumor imaging processing system according to an embodiment of the application.
  • the system 100 includes a medical imaging device 110, a network database 120, and a treatment device 130, wherein
  • the medical imaging device 110 may include a local medical imaging device 111 and/or a terminal medical imaging device 112.
  • the local medical imaging device 111 or the terminal medical imaging device 112 is used for venous vascular tumors based on the original DICOM data.
  • the identification, positioning, four-dimensional volume rendering, and abnormal analysis of venous vascular tumors in the target site can achieve four-dimensional three-dimensional imaging effects (the four-dimensional medical image specifically refers to the internal space of the displayed tissue Structural features and external spatial structural features.
  • the internal spatial structural features mean that the slice data inside the tissue has not been lost, that is, the medical imaging device can present the internal structure of tissues such as veins and blood vessels in the target site, and the external spatial structural characteristics refer to tissues and tissues.
  • the imaging device 112 can also be used to control the treatment device 130 to perform surgery on the venous vascular tumor at the target site.
  • the local medical imaging device 111 can also be used to edit the image source data to form a transfer function result of the four-dimensional human body image.
  • the transfer function result can include the transfer of the venous blood vessel surface and the tissue structure in the venous blood vessel.
  • the network database 120 may be, for example, a cloud server.
  • the network database 120 is used to store the image source generated by analyzing the original DICOM data and the transfer function result of the four-dimensional human body image edited by the local medical imaging device 111.
  • the image source may be from multiple sources.
  • a local medical imaging device 111 to realize interactive diagnosis of multiple doctors.
  • HMDS head-mounted Displays Set
  • the operating actions refer to the user’s actions through the medical imaging device.
  • External ingestion equipment such as mouse, keyboard, tablet (portable android device, Pad), iPad (internet portable apple device), etc., operate and control the four-dimensional human image to achieve human-computer interaction.
  • the operation actions include at least the following One: (1) Change the color and/or transparency of a specific organ/tissue, (2) Position the zoom view, (3) Rotate the view, realize the multi-view 360-degree observation of the four-dimensional human body image, (4) "Enter” Observe the internal structure of the skin, render the real-time clipping effect, and (5) move the view up and down.
  • FIG. 2A is a schematic flowchart of a venous vascular tumor image processing method according to an embodiment of the application. As shown in FIG. 2A, the venous vascular tumor image processing method described in this embodiment includes the following steps:
  • the medical imaging device acquires a scanned image of a target part of a target subject with a venous vascular tumor through VRDS 4D imaging technology.
  • the target object is a patient with a venous vascular tumor on the skin
  • the target site is a skin with a venous vascular tumor
  • the skin with a venous vascular tumor can be determined by a doctor based on the appearance of the skin symptoms
  • the scan image may be a CT image
  • the scan image may also be an MRI image
  • the scan image may also be a DTI image
  • the scan image may also be a PET-CT image, etc., which are not limited herein.
  • the medical imaging device can acquire scan images reflecting the internal structure of the skin with venous vascular tumors.
  • the medical imaging device generates 4D image data of multiple venous vessels of the target part according to the scanned image.
  • the medical imaging device generates 4D image data of multiple venous blood vessels of the target part according to the scanned image may be implemented as follows: the medical imaging device processes the scanned image to obtain the target part
  • the 4D image data includes 4D image data of the multiple venous blood vessels.
  • the medical imaging device inputs the skin scan images with venous vascular tumors collected at the local end into a VRDS (Virtual Reality Doctor system, VRDS) system to obtain 4D images of multiple venous blood vessels at the target site
  • a VRDS Virtual Reality Doctor system
  • the 4D image data of the plurality of venous vessels includes the internal spatial structure characteristics and the external spatial structure characteristics of the plurality of venous vessels.
  • the medical imaging device determines the target position of the venous vascular tumor in the multiple venous blood vessels according to the 4D image data of the multiple venous blood vessels.
  • the determining the target position of the venous vascular tumor in the multiple venous blood vessels according to the 4D image data of the multiple venous blood vessels includes: determining according to the 4D image data of the multiple venous blood vessels Smooth muscle image data and elastic fiber image data corresponding to the multiple venous blood vessels; determine abnormal data corresponding to the multiple venous blood vessels according to the smooth muscle image data and the elastic fiber image data; determine according to the abnormal data The target position of the venous blood vessel tumor in the plurality of venous blood vessels.
  • the internal spatial structure characteristics and the external spatial structural characteristics of the smooth muscle corresponding to the above-mentioned venous blood vessel and the elastic fiber are processed to determine the abnormal data in the above-mentioned space structure characteristics, for example, if the smooth muscle and elastic fibers corresponding to the above-mentioned veins and blood vessels correspond to the internal space structure characteristics and the external space structure characteristics and normal characteristics If the difference is too large, the smooth muscle and the corresponding venous segment where the elastic fiber is located can be determined as the target position.
  • the medical imaging device can determine the location of the venous vascular tumor by determining abnormal data in multiple venous 4D image data.
  • the medical imaging device determining the target position of the venous vascular tumor in the multiple venous blood vessels according to the 4D image data of the multiple venous blood vessels includes: the medical imaging device according to the multiple venous blood vessels
  • the 4D image data of venous blood vessels establishes a coordinate system, the origin of the coordinate system is any position of the target part, the X-axis, Y-axis, and Z-axis of the coordinate system are perpendicular to each other and follow the right-hand spiral rule; the medical imaging Starting from the origin of the coordinate system, the device performs detection along the positive and negative directions of the X axis, the positive and negative directions of the Y axis, and the positive and negative directions of the Z axis according to the preset distance.
  • the spatial position corresponding to the first pixel point is recorded, and whenever the The gray value corresponding to the second pixel point does not belong to the gray value corresponding to the venous blood vessel cell data in the outermost layer of the vein and the gray value corresponding to the adjacent pixel point of the second pixel point belongs to the vein in the outermost layer of the venous blood vessel.
  • the medical imaging device When the gray value corresponding to the blood vessel cell data, the spatial position corresponding to the second pixel point is recorded; the medical imaging device according to the spatial position corresponding to all the first pixel points and all the second pixel points correspond to The image data is segmented to obtain multiple outermost venous vascular cell data sets corresponding to multiple venous vessels, and each outermost venous vascular cell data set includes multiple outermost venous vascular cells Data; the medical imaging device performs the following steps for each outermost venous vascular cell data set: the medical imaging device obtains the characteristic curve of the currently processed outermost venous vascular cell data set projected on any plane; selects Any point of the characteristic curve is taken as the starting point; starting from the starting point, the pixel points are continuously marked along the positive and negative directions of the characteristic curve, and the marking stops when the target pixel point is marked.
  • the positive direction is the horizontal positive direction of the image data
  • the reverse direction of the characteristic curve is the horizontal reverse direction of the image data
  • the target pixel is the pixel with the largest change in the curvature of the target vein segment
  • the target vein The blood vessel segment is the venous blood vessel between the starting point and the target space position of the target venous blood vessel
  • the target venous blood vessel corresponds to the currently processed outermost venous blood vessel cell data set
  • the target space position is the target pixel Point corresponding to the position
  • obtain the curvature corresponding to the target venous blood vessel segment set the curvature corresponding to the target venous blood vessel segment as the corresponding curvature of the target venous blood vessel; compare the curvature with the standard curvature, so
  • the standard curvature is the curvature corresponding to the venous blood vessel under normal conditions; if the curvature does not match the standard curvature, the 4D image data of the target venous blood vessel segment is acquired; according to the curva
  • the curvature of the blood vessel is abnormal, which also indicates that there may be tumors. Therefore, the curvature of each venous blood vessel in the multiple venous blood vessels is determined by processing the 4D image data of multiple venous blood vessels, and the vein is determined according to the curvature of each venous blood vessel The location of vascular tumors enhances the purpose of venous blood vessels.
  • the method for determining the target position of the venous vascular tumor in the multiple venous vessels according to the 4D image data of the target venous blood vessel segment may be: according to the 4D image data of the target venous blood vessel segment , Determine the smooth muscle image data and elastic fiber image data corresponding to the target venous blood vessel segment; determine the abnormal data corresponding to the target venous blood vessel segment according to the smooth muscle image data and the elastic fiber image data; according to the abnormal data , Determining the target position of the venous vascular tumor in the multiple venous blood vessels.
  • the principle and processing method of this process are the same as the principle and processing method of determining the smooth muscle image data and elastic fiber image data corresponding to the multiple venous vessels according to the 4D image data of the multiple venous vessels.
  • the 4D image data of multiple venous vessels determines the related description of smooth muscle image data and elastic fiber image data corresponding to the multiple venous vessels, which will not be repeated here.
  • the target location includes one of the multiple venous blood vessels, or, at the intersection of m venous blood vessels of the multiple venous blood vessels, m is a positive integer greater than 1.
  • m may be 2, m may be 3, m may be 4, m may be 5, m may be 10, etc., and there is no specific limitation.
  • the electronic device can determine the specific location of the venous vascular tumor, so as to control the treatment device to perform surgical operations.
  • the medical imaging device outputs the 4D image data and the target position.
  • the output of the 4D image data and the target location by the medical imaging device may be displaying the 4D image data and the target location on the current display interface of the medical imaging device.
  • the medical imaging device may transmit the 4D image data and the target location to the treatment device, and the medical device displays the 4D image data and the target location on the current interface of the medical device.
  • the medical imaging device controls the treatment device to perform surgery according to the 4D image data and the target position.
  • FIG. 2B is a schematic structural diagram of a treatment device provided by an embodiment of the application.
  • the treatment device includes a puncture component 01 and a power supply unit 02, wherein the puncture component 01 includes a puncture body I, the puncture body I can be needle-shaped, the tip of the puncture body I is II, the puncture body I can puncture the venous blood vessel where the venous vascular tumor is generated or the living tissue near the location where the venous vascular tumor is generated Inside, the tip II of the puncture body is composed of a conductor; the power supply unit 02 punctures the puncture body I into the venous blood vessel where the venous vascular tumor is generated or the living body tissue near the location where the venous vascular tumor is generated, The power supply unit 02 supplies power to the puncture component 01 to heat the conductor position of the puncture component 01, that is, to heat the tip II of the puncture body to the venous blood vessel where the venous blood vessel where the venous
  • the medical imaging device controls the treatment device to perform the operation according to the 4D image data and the target position.
  • the medical imaging device may control the medical imaging device according to the 4D image data and the target position.
  • the treatment device punctures the puncture component of the medical imaging device to the living tissue near the target position or the venous blood vessel corresponding to the target position, and starts the power supply unit to supply power to the puncture component to realize the generation of venous blood vessels.
  • the target location is on one of the multiple venous vessels
  • the medical imaging device controls the treatment device to perform surgery according to the image data and the position information, including: The medical imaging device controls the treatment device to provide heat to the venous vessels with venous vascular tumors, and burns the venous vessels with venous vascular tumors.
  • the medical imaging device controls the treatment device to provide heat to the venous blood vessels with venous vascular tumors
  • the cauterization of the venous blood vessels with venous vascular tumors may be: the medical imaging device controls the control of the medical device The tip of the puncture body punctures the target position; the medical imaging device controls the power supply unit of the medical device to provide current to the puncture body of the medical device.
  • FIG. 2C is a partial schematic diagram of skin venous vascular tumor treatment through the puncture site of the treatment device according to an embodiment of the application.
  • the target position determined by the medical imaging device is When on one of the multiple venous blood vessels, control the tip of the puncture body of the medical device to penetrate the position of the venous blood vessel tumor, which is the target part in the dashed frame in FIG. 2C, and control the medical device to turn on the power supply unit , To provide current to the puncture part of the medical device, so that the tip of the puncture body of the medical device heats up, and burns the target position to block the venous blood vessel, that is, to block the blood flow of the generated vein.
  • the venous blood vessels recede and eventually the venous blood vessel tumors disappear from the skin surface.
  • the medical imaging device controls the treatment device to provide heat to the veins with venous vascular tumors, and the burning of the veins with venous vascular tumors may also be: the medical imaging device controls the medical device to determine the veins.
  • the position of the vascular tumor is the target position; the medical imaging device controls the medical device to determine the vein corresponding to the venous vascular tumor; the medical imaging device controls the tip of the puncture body of the medical device to penetrate the venous vascular tumor Nearby tissue, the tissue near the venous vascular tumor includes the vein corresponding to the venous vascular tumor; the medical imaging device controls the power supply unit of the medical device to provide current to the puncture body of the medical device.
  • FIG. 2D is another partial schematic diagram of skin venous vascular tumor treatment through the puncture site of the treatment device provided by the embodiment of the application.
  • the target position is determined on the medical imaging device.
  • the tissue includes the vein with a venous vascular tumor, and the nearby tissue may be A certain distance from the target position.
  • the certain distance can be any value between 1nm and 0.5cm.
  • the nearby tissue can be a position 0.1cm away from the target position.
  • the nearby tissue can be a distance from the target position.
  • the target position is 10nm, and the distance is not specifically limited.
  • the medical device is controlled to turn on the power supply unit to provide current to the puncture part of the medical device to make all
  • the tip of the puncture part of the medical device heats up, burns the tissue near the target location, and provides heat transfer to block the venous blood vessel with the venous vascular tumor, that is, block the blood flow of the venous blood vessel that produces the venous vascular tumor.
  • the venous blood vessels recede and eventually the venous blood vessel tumors disappear from the skin surface.
  • the target location is at the intersection of m venous vessels of the multiple venous vessels
  • the controlling the treatment device to perform surgery according to the image data and the position information includes: the medical The imaging device controls the treatment device to provide heat to the m venous blood vessels, respectively, to burn the m venous blood vessels.
  • the medical imaging device controls the treatment device to respectively provide heat to the m venous blood vessels
  • the implementation manner of burning the m venous blood vessels may be: the medical imaging device controls the puncture body of the medical device The tip of puncture sequentially into the m venous vessels near the target location or the tissue near the m venous vessels, and pierce the m venous vessels near the target location at the tip of the puncture body
  • the power supply unit of the medical device is controlled to provide current to the puncture body of the medical device when the tissues near the m venous blood vessels are used.
  • FIG. 2E is another partial schematic diagram of skin venous vascular tumor treatment through the puncture site of the treatment device according to an embodiment of the application. As shown in FIG. 2E, the target position is determined on the medical imaging device.
  • the medical imaging device may first control the medical device
  • the tip of the puncture body punctures the nail position near the position (target position) of the venous vascular tumor in the first venous blood vessel, and controls the power supply unit of the medical device to the nail position when the puncture body penetrates the nail position
  • the puncture body of the medical device supplies electric current, and then, the medical imaging device controls the tip of the puncture body of the medical device to pierce into the first venous blood vessel near the venous blood vessel tumor (target position) B position, and in the puncture body
  • the power supply unit of the medical device is controlled to provide current to the piercing body of the medical device.
  • the position close to the venous vascular tumor in the venous blood vessel with venous vascular tumor may be any position less than 0.5 cm from the position of the venous vascular tumor in the venous blood vessel with venous vascular tumor; in addition, The medical imaging device may also first control the tip of the puncture body of the medical device to first pierce the position near the venous vascular tumor (target position) and near the C position in the first venous blood vessel, and puncture at the tip of the puncture body In the C position, the power supply unit of the medical device is controlled to provide current to the puncture part of the medical device.
  • the medical imaging device controls the tip of the puncture body of the medical device to penetrate the venous vascular tumor (target position) and It is close to the D position in the first venous blood vessel, and when the tip of the puncture body penetrates the D position, the power supply unit of the medical device is controlled to provide current to the puncture body of the medical device.
  • the position close to the venous vascular tumor and close to the corresponding venous blood vessel may be any position of the tissue that is less than 0.5 cm from the position of the venous vascular tumor and less than 0.5 cm from the corresponding vein, and the distance is not specifically limited.
  • the medical imaging device controls the tip of the puncture body of the medical device to sequentially puncture the m venous vessels or the tissue near the m venous vessels near the target position, and puncture the tip of the puncture body
  • the power supply unit of the medical device controls the power supply unit of the medical device to provide current to the puncture part of the medical device to enable the puncture of the medical device
  • the tip of the body heats up, cauterizes the m venous vessels or the tissues near the m venous vessels near the target location, and provides heat transfer to block the venous vessels with venous vascular tumors, that is, The blood flow of the vein that produces the venous vascular tumor is blocked to shrink the venous blood vessel, and finally the venous vascular tumor disappears from the skin surface.
  • the target location is at the intersection of m venous vessels of the multiple venous vessels
  • the controlling the treatment device to perform surgery according to the image data and the position information includes: the medical The imaging device controls the treatment device to provide heat to the m venous blood vessels at the same time, and burn the m venous blood vessels.
  • the medical imaging device controls the treatment device to provide heat to the m venous vessels at the same time, and cauterizing the m venous vessels may be: the medical imaging device controls the puncture part of the medical device to penetrate into the place. The target position; the medical imaging device controls the power supply unit of the medical device to provide current to the puncture portion of the medical device.
  • FIG. 2F is another partial schematic diagram of skin venous vascular tumor treatment through the puncture site of the treatment device according to an embodiment of the application.
  • the target position is determined on the medical imaging device.
  • the tip of the puncture part of the medical device In order to control the tip of the puncture part of the medical device to pierce the position of the venous vascular tumor on the two venous vessels of the plurality of venous vessels, which is the target position in FIG.
  • the puncture part of the medical device provides electric current to make the tip of the puncture body of the medical device heat and burn the target position, so that the two venous vessels corresponding to the target position are blocked, that is, a venous vascular tumor will be generated.
  • the obstruction of the blood flow of the two venous vessels causes the venous vessels to shrink, and eventually the venous vessel tumors disappear from the skin surface.
  • step 204 and step 205 occur in no order and can occur at the same time.
  • the output of the 4D image data and the target position may be on the current display interface of the medical imaging device
  • a human-computer interaction window is displayed on the upper display, the human-computer interaction window includes the 4D image data and the target position and a virtual button that controls the activation of the treatment device to perform venous vascular tumor surgery on the skin part, such as "Immediate operation", when the user After selecting the virtual button, the medical imaging device controls the treatment device to perform venous vascular tumor surgery; the output of the 4D image data and the target position may be displayed on the current display interface of the treatment device
  • the human-computer interaction window which includes the 4D image data and the target position, and a virtual button that controls the start of the treatment device for venous vascular tumor surgery on the skin part, such as "Surgery now", when the user selects After the virtual button, the treatment device will perform venous vascular tumor surgery under the control of the medical imaging device; the
  • the medical imaging device first obtains the scanned image of the user's target site with venous vascular tumor through VRDS 4D imaging technology, and then generates the target based on the scanned image 4D image data of multiple venous blood vessels in the region, and then determine the target position of the venous vascular tumor in the multiple venous blood vessels based on the 4D image data of the multiple venous blood vessels, and finally, output the 4D image data and the target position, synchronously, and control
  • the treatment device performs surgery based on the 4D image data and the target location. It can be seen that the medical imaging device provided in this embodiment can accurately locate the position of the venous vascular tumor based on 4D image data, which is beneficial to improve the accuracy of venous vascular tumor positioning.
  • the medical imaging device determining the smooth muscle image data and elastic fiber image data corresponding to the multiple venous vessels according to the 4D image data of the multiple venous vessels includes: the medical imaging device according to The 4D image data of the multiple venous vessels determines the spatial coordinates of each of the 4D image data of the multiple venous vessels to obtain multiple spatial coordinates; the medical imaging device is based on the multiple spatial coordinates , Determine the smooth muscle space coordinate set and the elastic fiber space coordinate set corresponding to the multiple venous vessels; the medical imaging device determines the all corresponding to the multiple venous vessels according to the smooth muscle space coordinate set and the elastic fiber space coordinate set The smooth muscle image data and the elastic fiber data.
  • the above-mentioned multiple venous vessel 4D image data reflects the spatial structure characteristics of each component of the vein part
  • the above-mentioned spatial structure feature can be used to determine the target location of the venous vessel tumor, specifically, multiple venous vessel tumors can be determined.
  • the multiple data corresponding to each component of the venous blood vessel are obtained, and the multiple spatial coordinates corresponding to the above multiple components are obtained.
  • Each component can correspond to multiple spatial coordinates.
  • the multiple 4D image data of the multiple venous blood vessels are the data of each component
  • multiple target spatial coordinates corresponding to smooth muscles and elastic fibers in multiple venous vessels can be determined.
  • the medical imaging device determining abnormal data corresponding to the multiple venous vessels according to the smooth muscle image data and the elastic fiber image data includes: the medical imaging device according to the multiple The smooth muscle image data and the elastic fiber data corresponding to the venous blood vessels are used to generate smooth muscle characteristic data and elastic fiber characteristic data corresponding to the multiple venous blood vessels, the characteristic data being used to reflect the spatial position and thickness;
  • the medical imaging device compares the smooth muscle characteristic data and elastic fiber characteristic data corresponding to the multiple venous blood vessels with a preset normal data set corresponding to the multiple venous blood vessels, and the preset normal venous blood vessel characteristic data set includes The smooth muscle standard feature data and the elastic fiber standard feature data; if they do not match, the corresponding feature data is determined to be abnormal data corresponding to the multiple venous blood vessels.
  • the abnormal data may be data corresponding to a position where a venous vascular tumor grows on the skin.
  • the preset normal data may be preset by the user.
  • a venous vascular tumor of the skin grows, it is a highly dilated vascular disease.
  • the corresponding preset normal data sets under normal conditions are compared, and if they do not match, it is determined that the corresponding feature data is abnormal data corresponding to the multiple venous blood vessels.
  • the medical imaging device determining the target position of the venous vascular tumor in the multiple venous vessels according to the 4D image data of the multiple venous vessels includes: the medical imaging device according to the The 4D image data of the multiple venous vessels determines the smooth muscle image data and the elastic fiber image data corresponding to the multiple venous vessels; the medical imaging device determines the smooth muscle image data and the elastic fiber image data according to the smooth muscle image data and the elastic fiber image data.
  • the tumor cells of the skin veins are limited to the multiple venous vascular structures under the skin
  • the internal spatial structure characteristics of the smooth muscles corresponding to the multiple venous vessels can be determined and
  • the external space structure characteristics, the internal space structure characteristics of the elastic fibers, and the external space structure characteristics are processed to determine the abnormal data in the above-mentioned space structure characteristics, for example, if the above-mentioned smooth muscle and elastic fibers correspond to the internal space structure characteristics and the external space structure
  • the feature is too different from the normal feature, it can be determined that the target location corresponding to the tumor is the location of the smooth muscle and elastic fiber of the opposite sex; in this way, the 4D image data of the multiple venous blood vessels can be used to accurately locate the venous blood vessels The location of the tumor.
  • the medical imaging device generating 4D image data of multiple venous vessels of the target part according to the scanned image includes: the medical imaging device obtains a bitmap BMP data source according to the scanned image The medical imaging device imports the BMP data source into a preset VRDS medical network model to obtain first medical image data, the first medical image data including the 4D venous vessel data set of the multiple venous vessels; The medical imaging device imports the first medical image data into a preset cross-vascular network model to obtain second medical image data, the second medical image data includes a smooth muscle data set and an elastic fiber data set; the medical imaging device Performing a second preset processing on the second medical image data to obtain target 4D medical image data, the target 4D medical image data includes: 4D venous blood vessel data sets of the multiple venous blood vessels, the smooth muscle data set, and The elastic fiber data set.
  • the medical imaging device obtaining the bitmap BMP data source according to the scanned image includes performing at least one of the following operations: VRDS limited contrast adaptive histogram equalization, hybrid partial differential denoising, VRDS Ai elastic deformation processing, etc. , Not limited here; among them, limiting the contrast specifically includes regional noise contrast limiting and global contrast limiting; the local histogram of the image source is divided into multiple partitions, for each partition, according to the cumulative histogram of the neighborhood of the partition The slope of the graph determines the slope of the transformation function, and the degree of contrast magnification around the pixel value of the partition is determined according to the gradient of the transformation function, and then the limit cropping process is performed according to the degree of contrast magnification to produce the distribution of the effective histogram.
  • the isoilluminance lines (including edges) formed by the objects in the natural image should be sufficiently smooth and smooth, that is, the absolute value of the curvature of these isoilluminance lines should be small enough. After the image is contaminated by noise, the local gray value of the image will fluctuate randomly, resulting in irregular oscillations of the isoilluminance lines, forming isoilluminance lines with a large local curvature.
  • the design adopts VRDS Ai curvature drive and VRDS Ai High-order hybrid denoising, to achieve a hybrid partial differential denoising model that can protect the edge of the image and avoid the step effect in the smoothing process; among them, the VRDS Ai elastic deformation process is superimposed on the original lattice, and the positive and negative random distances are superimposed to form a difference The value position matrix, and then the grayscale at each difference position, forms a new dot matrix, which can realize the distortion and deformation of the image, and then rotate, distort, and translate the image.
  • the medical imaging device imports the BMP data source into the preset VRDS medical network model to obtain the first medical image data by calling each transfer in the set of pre-stored transfer functions through the VRDS medical network model.
  • the BMP data source is processed by a plurality of transfer functions in the transfer function set to obtain the first medical image data
  • the transfer function set may include the preset value of each vein in the plurality of veins by a reverse editor.
  • the transfer function in addition, the transfer function of each vein may include: a smooth muscle transfer function of each vein and an elastic fiber transfer function of each vein.
  • the medical imaging device imports the first medical image data into a preset cross-vessel network model, and obtains the second medical image data by performing data segmentation through the cross-vessel network model to obtain the multiple veins.
  • the smooth muscle data set and the elastic fiber data set of the blood vessel, the first data in the smooth muscle data set of the multiple venous blood vessels and the second data in the data set of the elastic fiber data set are independent of each other, and the above-mentioned first data is associated with the smooth muscle intersection position
  • the above-mentioned second data is the data associated with the intersection position of the elastic fiber.
  • the second medical image data can be obtained. In this way, the data corresponding to the smooth muscle and the data corresponding to the elastic fiber can be achieved through the cross-vascular network model. Data segmentation.
  • the second preset processing includes at least one of the following methods: 2D boundary optimization processing, 3D boundary optimization processing, data enhancement processing, etc., which are not limited here; the above 2D boundary optimization processing includes: multiple sampling to obtain low resolution Rate information and high-resolution information.
  • the low-resolution information can provide the contextual semantic information of the segmentation target in the entire image, that is, the features that reflect the relationship between the segmentation target and the environment. These features are used for object category judgment, high resolution
  • the rate information is used to provide more refined features for the segmentation target, such as gradient, etc., where the segmentation target may include multiple venous vessels, and each vein of the multiple venous vessels may include smooth muscle and elastic fibers.
  • FIG. 3 is a schematic structural diagram of a medical imaging device provided by an embodiment of the application.
  • the medical imaging device 300 includes a processor 310, a memory 320, a communication interface 330, and one or more programs 321, wherein the one or more programs 321 are stored in the above-mentioned memory 320 and are configured to be executed by the above-mentioned processor 310, and the one or more The program 321 includes instructions for performing the following steps:
  • the treatment device is controlled to perform surgery according to the 4D image data and the target position.
  • the medical imaging device first obtains the scanned image of the user's target site with venous vascular tumor through VRDS 4D imaging technology, and then generates the target based on the scanned image 4D image data of multiple venous blood vessels in the region, and then determine the target position of the venous vascular tumor in the multiple venous blood vessels based on the 4D image data of the multiple venous blood vessels, and finally, output the 4D image data and the target position, synchronously, and control
  • the treatment device performs surgery based on the 4D image data and the target location. It can be seen that the medical imaging device provided in this embodiment can accurately locate the position of the venous vascular tumor based on 4D image data, which is beneficial to improve the accuracy of cutaneous venous vascular tumor positioning.
  • the one or more programs 321 The instruction is specifically used to perform the following steps: according to the 4D image data of the multiple venous vessels, determine the smooth muscle image data and elastic fiber image data corresponding to the multiple venous vessels; according to the smooth muscle image data and the elastic fiber image Data, determining abnormal data corresponding to the multiple venous blood vessels; and determining the target position of the venous blood vessel tumor in the multiple venous blood vessels according to the abnormal data.
  • the one or more programs 321 The instruction is specifically used to perform the following steps: according to the 4D image data of the multiple venous vessels, determine the spatial coordinates of each 4D image data of the multiple venous vessels to obtain multiple spatial coordinates; The multiple spatial coordinates are determined to determine the smooth muscle space coordinate set and the elastic fiber spatial coordinate set corresponding to the multiple venous vessels; and the smooth muscle spatial coordinate set and the elastic fiber spatial coordinate set are determined according to the smooth muscle spatial coordinate set and the elastic fiber spatial coordinate set to determine the all corresponding to the multiple venous vessels.
  • the smooth muscle image data and the elastic fiber data are specifically used to perform the following steps: according to the 4D image data of the multiple venous vessels, determine the spatial coordinates of each 4D image data of the multiple venous vessels to obtain multiple spatial coordinates; The multiple spatial coordinates are determined to determine the smooth muscle space coordinate set and the elastic fiber spatial coordinate set corresponding to the multiple venous vessels; and the smooth muscle spatial coordinate set and the elastic fiber spatial coordinate set are determined according to the smooth muscle spatial coordinate set and the
  • the instructions of the one or more programs 321 are specifically used The following steps are performed: according to the smooth muscle image data and the elastic fiber data corresponding to the multiple venous blood vessels, the feature data of the smooth muscle and the elastic fiber corresponding to the multiple venous blood vessels are generated, the feature data Used to reflect the spatial position and thickness; the feature data of smooth muscle and elastic fiber corresponding to the multiple venous vessels are compared with the preset normal data set corresponding to the multiple venous vessels, the preset venous vessels
  • the normal feature data set includes smooth muscle standard feature data and elastic fiber standard feature data; if there is no match, the corresponding feature data is determined to be abnormal data corresponding to the multiple venous blood vessels.
  • the instructions of the one or more programs 321 are specifically used to execute The following steps: determine the spatial position data corresponding to the abnormal data; determine the spatial position data corresponding to the venous vascular tumor according to the spatial position data corresponding to the abnormal data; The venous vascular tumor is located, and the target position of the venous vascular tumor in the multiple venous blood vessels is obtained.
  • m is greater than 1. A positive integer.
  • the target location is on one of the multiple venous vessels.
  • the instructions of the one or more programs 321 are specifically used to perform the following steps: control the treatment device to provide heat to the veins with venous vascular tumors, and to burn the veins with venous vascular tumors.
  • the target location is at the intersection of m venous vessels of the multiple venous vessels
  • the treatment device is controlled to perform surgery according to the image data and the position information
  • the instructions of the one or more programs 321 are specifically used to perform the following steps: controlling the treatment device to respectively provide heat to the m venous blood vessels, and cauterizing the m venous blood vessels.
  • the instructions of the one or more programs 321 are specifically used to perform the following steps:
  • the scanned image obtains a bitmap BMP data source;
  • the BMP data source is imported into a preset VRDS medical network model to obtain first medical image data, and the first medical image data includes 4D veins of the multiple venous vessels Blood vessel data set;
  • the medical image data executes a second preset processing to obtain target 4D medical image data
  • the target 4D medical image data includes: 4D venous blood vessel data sets of the multiple venous blood vessels, the smooth muscle data set, and the elastic fiber data set .
  • FIG. 4 is a schematic structural diagram of a venous vascular tumor imaging processing device provided by an embodiment of the application.
  • the venous vascular tumor imaging processing device 400 described in this embodiment includes: acquiring The unit 401, the processing unit 402, the determining unit 403, the output unit 404, and the control unit 405 are specifically as follows:
  • the acquiring unit 401 is configured to acquire a scanned image of the user's target site with venous vascular tumors through VRDS 4D imaging technology;
  • the processing unit 402 is configured to generate 4D image data of multiple venous vessels of the target part according to the scanned image;
  • the determining unit 403 is configured to determine the target position of the venous vascular tumor in the multiple venous blood vessels according to the 4D image data of the multiple venous blood vessels;
  • the output unit 404 is configured to output the 4D image data and the target position
  • the control unit 405 is configured to control the treatment device to perform surgery according to the 4D image data and the target position.
  • the medical imaging device first obtains the scanned image of the user's target site with venous vascular tumor through VRDS 4D imaging technology, and then generates the target based on the scanned image 4D image data of multiple venous blood vessels in the region, and then determine the target position of the venous vascular tumor in the multiple venous blood vessels based on the 4D image data of the multiple venous blood vessels, and finally, output the 4D image data and the target position, synchronously, and control
  • the treatment device performs surgery based on the 4D image data and the target location. It can be seen that the medical imaging device provided in this embodiment can accurately locate the position of the venous vascular tumor based on 4D image data, which is beneficial to improve the accuracy of cutaneous venous vascular tumor positioning.
  • the determining unit 403 is specifically configured to:
  • the target position of the venous blood vessel tumor in the plurality of venous blood vessels is determined.
  • the determining unit 403 is specifically configured to:
  • the smooth muscle image data and the elastic fiber data corresponding to the multiple venous blood vessels are determined.
  • the determining unit 403 is specifically configured to:
  • feature data of the smooth muscle and the elastic fiber corresponding to the multiple venous blood vessels are generated, and the feature data is used to reflect the spatial position And thickness;
  • the feature data of smooth muscle corresponding to the multiple venous vessels and the feature data of elastic fibers are compared with a preset normal data set corresponding to the multiple venous vessels, where the preset normal feature data of venous vessels includes smooth muscle standard features Data and elastic fiber standard characteristic data;
  • the corresponding feature data is abnormal data corresponding to the multiple venous blood vessels.
  • the determining unit 403 is specifically configured to:
  • the venous vascular tumor is located according to the spatial position data corresponding to the venous vascular tumor, and the target position of the venous vascular tumor in the multiple venous blood vessels is obtained.
  • the target location includes one of the multiple venous vessels, or, at the intersection of m venous vessels of the multiple venous vessels, m is a positive value greater than 1. Integer.
  • the target location is on one of the multiple venous vessels.
  • the The control unit 405 is specifically used for:
  • the treatment device is controlled to provide heat to the veins with venous vascular tumors, and to burn the veins with venous vascular tumors.
  • the target location is at the intersection of m venous vessels of the multiple venous vessels, in terms of controlling the treatment device to perform surgery according to the image data and the position information,
  • the control unit 405 is specifically configured to:
  • the treatment device is controlled to provide heat to the m venous blood vessels respectively, and the m venous blood vessels are burnt.
  • the processing unit 402 is specifically configured to:
  • the BMP data source Importing the BMP data source into a preset VRDS medical network model to obtain first medical image data, where the first medical image data includes 4D venous blood vessel data sets of the multiple venous blood vessels;
  • the first medical image data into a preset cross blood vessel network model to obtain second medical image data, the second medical image data including a smooth muscle data set and an elastic fiber data set;
  • the target 4D medical image data includes: 4D venous blood vessel data sets of the multiple venous blood vessels, the smooth muscle data set, and The elastic fiber data set.
  • each program module of the venous vascular tumor imaging processing apparatus of this embodiment can be implemented in detail according to the method in the above method embodiment.
  • An embodiment of the present application also provides a computer storage medium, wherein the computer storage medium stores a computer program for electronic data exchange, and the computer program enables a computer to perform any of the venous vascular tumor image processing described in the above method embodiment Part or all of the steps of the method.
  • the embodiments of the present application also provide a computer program product.
  • the computer program product includes a non-transitory computer-readable storage medium storing a computer program.
  • the computer program is operable to cause a computer to execute the method described in the foregoing method embodiment. Part or all of the steps of any image processing method for venous vascular tumors.
  • the disclosed device may be implemented in other ways.
  • the device embodiments described above are merely illustrative, for example, the division of the units is only a logical function division, and there may be other divisions in actual implementation, for example, multiple units or components may be combined or may be Integrate into another system, or some features can be ignored or not implemented.
  • the displayed or discussed mutual coupling or direct coupling or communication connection may be indirect coupling or communication connection through some interfaces, devices or units, and may be in electrical or other forms.
  • the units described as separate components may or may not be physically separated, and the components displayed as units may or may not be physical units, that is, they may be located in one place, or they may be distributed on multiple network units. Some or all of the units may be selected according to actual needs to achieve the objectives of the solutions of the embodiments.
  • the functional units in the various embodiments of the present application may be integrated into one processing unit, or each unit may exist alone physically, or two or more units may be integrated into one unit.
  • the above-mentioned integrated unit can be realized in the form of hardware or software program module.
  • the integrated unit is implemented in the form of a software program module and sold or used as an independent product, it can be stored in a computer readable memory.
  • the technical solution of the present application essentially or the part that contributes to the existing technology or all or part of the technical solution can be embodied in the form of a software product, and the computer software product is stored in a memory.
  • a number of instructions are included to enable a computer device (which may be a personal computer, a server, or a network device, etc.) to perform all or part of the steps of the methods described in the various embodiments of the present application.
  • the foregoing memory includes: U disk, read-only memory (read-only memory, ROM), random access memory (random access memory, RAM), mobile hard disk, magnetic disk or optical disk and other media that can store program codes.
  • the program can be stored in a computer-readable memory, and the memory can include: a flash disk , ROM, RAM, magnetic disk or CD, etc.

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Abstract

L'invention concerne un procédé de traitement d'image de tumeur veineuse appliqué à un appareil d'imagerie médicale. Le procédé comprend les étapes suivantes : un appareil d'imagerie médicale (110) acquiert tout d'abord une image balayée d'un site cible d'un utilisateur ayant une tumeur veineuse au moyen d'une technologie d'imagerie 4D VRDS (201) ; l'appareil d'imagerie médicale génère ensuite des données d'image 4D d'une pluralité de veines au niveau du site cible selon l'image balayée (202) ; puis l'appareil d'imagerie médicale détermine des positions cibles de la tumeur veineuse dans la pluralité de veines selon les données d'image 4D de la pluralité de veines (203) ; enfin, l'appareil d'imagerie médicale délivre en sortie les données d'image 4D et les positions cibles (204) ; et en synchronisation avec l'étape précédente, l'appareil d'imagerie médicale commande un appareil de traitement pour effectuer une opération selon les données d'image 4D et les positions cibles (205). Par conséquent, la position d'une tumeur veineuse peut être localisée avec précision sur la base de données d'image 4D, ce qui aide à améliorer la précision de l'emplacement d'une tumeur veineuse cutanée. L'invention concerne en outre un appareil de traitement d'image correspondant, un appareil d'imagerie médicale, un support de stockage et un produit-programme.
PCT/CN2019/114487 2019-10-30 2019-10-30 Procédé de traitement d'image de tumeur veineuse et produit associé WO2021081846A1 (fr)

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