WO2021072450A3 - Novel nutrients to enhance load-induced muscle hypertrophy - Google Patents

Novel nutrients to enhance load-induced muscle hypertrophy Download PDF

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Publication number
WO2021072450A3
WO2021072450A3 PCT/US2021/013613 US2021013613W WO2021072450A3 WO 2021072450 A3 WO2021072450 A3 WO 2021072450A3 US 2021013613 W US2021013613 W US 2021013613W WO 2021072450 A3 WO2021072450 A3 WO 2021072450A3
Authority
WO
WIPO (PCT)
Prior art keywords
muscle hypertrophy
induced muscle
enhance load
novel
nutrients
Prior art date
Application number
PCT/US2021/013613
Other languages
French (fr)
Other versions
WO2021072450A2 (en
Inventor
Keith Baar
Andrew PHILP
Simon SCHENK
Original Assignee
The Regents Of The University Of California
University Of Birmingham
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of California, University Of Birmingham filed Critical The Regents Of The University Of California
Priority to JP2022554876A priority Critical patent/JP2023517997A/en
Priority to CN202180020509.0A priority patent/CN115348821A/en
Priority to BR112022017939A priority patent/BR112022017939A2/en
Priority to CA3175049A priority patent/CA3175049A1/en
Priority to EP21705006.1A priority patent/EP4117455A2/en
Priority to US17/183,252 priority patent/US11312695B2/en
Publication of WO2021072450A2 publication Critical patent/WO2021072450A2/en
Publication of WO2021072450A3 publication Critical patent/WO2021072450A3/en

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/37—Celastraceae (Staff-tree or Bittersweet family), e.g. tripterygium or spindletree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06—Anabolic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

Methods and compositions are provided for increasing muscle hypertrophy, e.g., through the administration of novel combinations of natural products that inhibit SIRT1.
PCT/US2021/013613 2020-03-10 2021-01-15 Novel nutrients to enhance load-induced muscle hypertrophy WO2021072450A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2022554876A JP2023517997A (en) 2020-03-10 2021-01-15 A novel nutrient for enhancing load-induced muscle hypertrophy
CN202180020509.0A CN115348821A (en) 2020-03-10 2021-01-15 Novel nutrient for enhancing load-induced muscle hypertrophy
BR112022017939A BR112022017939A2 (en) 2020-03-10 2021-01-15 NUTRIENTS TO INCREASE LOAD-INDUCED MUSCLE HYPERTROPHY
CA3175049A CA3175049A1 (en) 2020-03-10 2021-01-15 Novel nutrients to enhance load-induced muscle hypertrophy
EP21705006.1A EP4117455A2 (en) 2020-03-10 2021-01-15 Novel nutrients to enhance load-induced muscle hypertrophy
US17/183,252 US11312695B2 (en) 2020-03-10 2021-02-23 Nutrients to enhance load-induced muscle hypertrophy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062987807P 2020-03-10 2020-03-10
US62/987,807 2020-03-10

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US17/183,252 Continuation US11312695B2 (en) 2020-03-10 2021-02-23 Nutrients to enhance load-induced muscle hypertrophy

Publications (2)

Publication Number Publication Date
WO2021072450A2 WO2021072450A2 (en) 2021-04-15
WO2021072450A3 true WO2021072450A3 (en) 2021-05-27

Family

ID=74592760

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2021/013613 WO2021072450A2 (en) 2020-03-10 2021-01-15 Novel nutrients to enhance load-induced muscle hypertrophy

Country Status (7)

Country Link
US (1) US11312695B2 (en)
EP (1) EP4117455A2 (en)
JP (1) JP2023517997A (en)
CN (1) CN115348821A (en)
BR (1) BR112022017939A2 (en)
CA (1) CA3175049A1 (en)
WO (1) WO2021072450A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112022017939A2 (en) 2020-03-10 2022-11-16 Univ California NUTRIENTS TO INCREASE LOAD-INDUCED MUSCLE HYPERTROPHY

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013142816A1 (en) * 2012-03-23 2013-09-26 Cardero Therapeutics, Inc. Compounds and compositions for the treatment of muscular disorders
JP2015012986A (en) * 2013-07-05 2015-01-22 花王株式会社 Muscle-strengthening kit
US20150025052A1 (en) * 2013-07-16 2015-01-22 Georgia Regents Research Institute, Inc. Compositions and Methods for Inhibiting HSP90/HSP70 Machinery
WO2015094772A1 (en) * 2013-12-18 2015-06-25 Abbott Laboratories Methods for increasing skeletal muscle protein synthesis using green tea extract
US9480675B2 (en) * 2013-01-11 2016-11-01 The Regents Of The University Of California Method for increasing muscle growth by blocking sirtuin activity
JP2016199536A (en) * 2015-04-07 2016-12-01 株式会社ニュートリション・アクト Compositions for enhancing muscles and improving metabolic syndrome, as well as improving qol
KR101692081B1 (en) * 2011-02-25 2017-01-03 연세대학교 원주산학협력단 Composition for preventing or treating skeletal muscle atrophy comprising celastrol
WO2018166404A1 (en) * 2017-03-15 2018-09-20 中国科学院昆明植物研究所 Uses of celastrol in preventing and/or treating cholestatic liver disease and liver fibrosis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE537819T1 (en) * 2005-10-14 2012-01-15 Dsm Ip Assets Bv NUTRACEUTICAL COMPOSITIONS FOR TREATING MUSCLE WASTING
SG11201507135XA (en) * 2013-03-15 2015-10-29 Abbott Lab Methods of maintaining and improving muscle function
MX2015015178A (en) * 2013-05-01 2016-02-26 Abbott Lab Methods for enhancing aged muscle regeneration.
BR112022017939A2 (en) 2020-03-10 2022-11-16 Univ California NUTRIENTS TO INCREASE LOAD-INDUCED MUSCLE HYPERTROPHY

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101692081B1 (en) * 2011-02-25 2017-01-03 연세대학교 원주산학협력단 Composition for preventing or treating skeletal muscle atrophy comprising celastrol
WO2013142816A1 (en) * 2012-03-23 2013-09-26 Cardero Therapeutics, Inc. Compounds and compositions for the treatment of muscular disorders
US9480675B2 (en) * 2013-01-11 2016-11-01 The Regents Of The University Of California Method for increasing muscle growth by blocking sirtuin activity
JP2015012986A (en) * 2013-07-05 2015-01-22 花王株式会社 Muscle-strengthening kit
US20150025052A1 (en) * 2013-07-16 2015-01-22 Georgia Regents Research Institute, Inc. Compositions and Methods for Inhibiting HSP90/HSP70 Machinery
WO2015094772A1 (en) * 2013-12-18 2015-06-25 Abbott Laboratories Methods for increasing skeletal muscle protein synthesis using green tea extract
JP2016199536A (en) * 2015-04-07 2016-12-01 株式会社ニュートリション・アクト Compositions for enhancing muscles and improving metabolic syndrome, as well as improving qol
WO2018166404A1 (en) * 2017-03-15 2018-09-20 中国科学院昆明植物研究所 Uses of celastrol in preventing and/or treating cholestatic liver disease and liver fibrosis

Also Published As

Publication number Publication date
EP4117455A2 (en) 2023-01-18
CN115348821A (en) 2022-11-15
JP2023517997A (en) 2023-04-27
BR112022017939A2 (en) 2022-11-16
US20210214329A1 (en) 2021-07-15
WO2021072450A2 (en) 2021-04-15
US11312695B2 (en) 2022-04-26
CA3175049A1 (en) 2021-04-15

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