WO2021066094A1 - Tooth whitening method - Google Patents
Tooth whitening method Download PDFInfo
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- WO2021066094A1 WO2021066094A1 PCT/JP2020/037417 JP2020037417W WO2021066094A1 WO 2021066094 A1 WO2021066094 A1 WO 2021066094A1 JP 2020037417 W JP2020037417 W JP 2020037417W WO 2021066094 A1 WO2021066094 A1 WO 2021066094A1
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- mouthpiece
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- lactic acid
- tooth whitening
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C19/00—Dental auxiliary appliances
- A61C19/06—Implements for therapeutic treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
The present invention addresses the problem of providing a tooth whitening method by which teeth can be effectively whitened without damaging the teeth and a positive effect is also expected in an oral environment. A tooth whitening method according to the present invention is characterized by including the following steps [1]-[4] of: [1] applying the saliva of a subject to the inside of a mouthpiece that can be attached to a portion of the teeth and gums in the oral cavity; [2] spraying lactobacillus granules onto the saliva applied to the inside of the mouthpiece, or mixing a lactobacillus agent with the saliva; [3] attaching the mouthpiece to the teeth and gums of the subject; and [4] closing the lips and maintaining that state for at least several hours.
Description
本発明は、歯のホワイトニング方法に関する。
The present invention relates to a tooth whitening method.
近年、歯のホワイトニング需要の向上に合わせて様々なホワイトニング材の開発が進んでいる（例えば特許文献１）。この中で一番効果が高いのは、歯科医院で行われている劇物指定の過酸化水素によるホワイトニング（オフィスホワイトニング）であることは周知の事実である。しかしながら、過酸化水素によるホワイトニングは、痛みの発現と脱水症状、エナメルタンパクの溶解の問題がある。また、そもそも過酸化水素が劇物であることは大きな問題である。歯のホワイトニングにより歯が白くなるのは良いが、歯が脆くなっては意味がない。そのため、歯にダメージを与えることなく、歯を効果的に白くすることができ、かつ、口腔内の環境にも良い効果が望める歯のホワイトニング方法が求められている。
In recent years, various whitening materials have been developed in response to the increasing demand for tooth whitening (for example, Patent Document 1). It is a well-known fact that the most effective of these is whitening (office whitening) with hydrogen peroxide, which is designated as a deleterious substance at dental clinics. However, whitening with hydrogen peroxide has problems of pain development, dehydration, and enamel protein dissolution. Moreover, it is a big problem that hydrogen peroxide is a deleterious substance in the first place. Whitening teeth is good for whitening teeth, but it is meaningless for teeth to become brittle. Therefore, there is a demand for a tooth whitening method that can effectively whiten teeth without damaging the teeth and can be expected to have a good effect on the oral environment.
本発明は上記問題に鑑みてなされたもので、その目的は、歯にダメージを与えることなく、歯を効果的に白くすることができ、かつ、口腔内の環境にも良い効果が望める歯のホワイトニング方法を提供することにある。
The present invention has been made in view of the above problems, and an object of the present invention is to provide a tooth that can effectively whiten teeth without damaging the teeth and is expected to have a good effect on the oral environment. To provide a whitening method.
上記目的を達成するため、本発明にかかる歯のホワイトニング方法は、少なくとも下記の手順〔１〕～〔４〕を含むことを特徴とする。
〔１〕口腔内の歯及び歯茎の一部に装着可能なマウスピースの内部に対象者本人の唾液を塗布する。
〔２〕前記マウスピースの内部に塗布した唾液上に乳酸菌顆粒を散布、もしくは乳酸菌剤を混合する。
〔３〕前記マウスピースを対象者の歯及び歯茎に装着する。
〔４〕その状態で、口唇を閉じて少なくとも数時間放置する。望ましくは一晩そのままで放置する。 In order to achieve the above object, the tooth whitening method according to the present invention is characterized by including at least the following procedures [1] to [4].
[1] The subject's saliva is applied to the inside of the mouthpiece that can be attached to a part of the teeth and gums in the oral cavity.
[2] Lactic acid bacteria granules are sprayed or mixed with a lactic acid bacterium agent on saliva applied to the inside of the mouthpiece.
[3] The mouthpiece is attached to the subject's teeth and gums.
[4] In that state, close the lips and leave it for at least several hours. Desirably, leave it as it is overnight.
〔１〕口腔内の歯及び歯茎の一部に装着可能なマウスピースの内部に対象者本人の唾液を塗布する。
〔２〕前記マウスピースの内部に塗布した唾液上に乳酸菌顆粒を散布、もしくは乳酸菌剤を混合する。
〔３〕前記マウスピースを対象者の歯及び歯茎に装着する。
〔４〕その状態で、口唇を閉じて少なくとも数時間放置する。望ましくは一晩そのままで放置する。 In order to achieve the above object, the tooth whitening method according to the present invention is characterized by including at least the following procedures [1] to [4].
[1] The subject's saliva is applied to the inside of the mouthpiece that can be attached to a part of the teeth and gums in the oral cavity.
[2] Lactic acid bacteria granules are sprayed or mixed with a lactic acid bacterium agent on saliva applied to the inside of the mouthpiece.
[3] The mouthpiece is attached to the subject's teeth and gums.
[4] In that state, close the lips and leave it for at least several hours. Desirably, leave it as it is overnight.
また、この歯のホワイトニング方法では、前記マウスピースは、対象者の歯茎部分に密着させた形状であることが望ましい。そして、そのようなマウスピースを作製する手順として、更に下記の手順〔５〕、〔６〕を前記手順〔１〕～〔４〕の前に行うようにしてもよい。
〔５〕対象者の口腔内印象を印象材にて取り、当該口腔内の石膏模型を作製する。
〔６〕前記石膏模型にマウスピース用シートを加熱密着させ、対象者の歯茎部分に密着させた形状のマウスピースを作製する。 Further, in this tooth whitening method, it is desirable that the mouthpiece has a shape that is in close contact with the gum portion of the subject. Then, as a procedure for producing such a mouthpiece, the following steps [5] and [6] may be further performed before the above steps [1] to [4].
[5] The impression of the oral cavity of the subject is taken with an impression material, and a plaster model of the oral cavity is prepared.
[6] A mouthpiece sheet is heated and brought into close contact with the gypsum model to prepare a mouthpiece having a shape that is brought into close contact with the gum portion of the subject.
〔５〕対象者の口腔内印象を印象材にて取り、当該口腔内の石膏模型を作製する。
〔６〕前記石膏模型にマウスピース用シートを加熱密着させ、対象者の歯茎部分に密着させた形状のマウスピースを作製する。 Further, in this tooth whitening method, it is desirable that the mouthpiece has a shape that is in close contact with the gum portion of the subject. Then, as a procedure for producing such a mouthpiece, the following steps [5] and [6] may be further performed before the above steps [1] to [4].
[5] The impression of the oral cavity of the subject is taken with an impression material, and a plaster model of the oral cavity is prepared.
[6] A mouthpiece sheet is heated and brought into close contact with the gypsum model to prepare a mouthpiece having a shape that is brought into close contact with the gum portion of the subject.
本発明によれば、乳酸菌によって、歯にダメージを与えることなく、歯を効果的に白くすることができ、かつ、口腔内の環境にも良い効果がある歯のホワイトング方法を提供することができる。
According to the present invention, it is possible to provide a tooth whitening method capable of effectively whitening teeth without damaging the teeth by lactic acid bacteria and also having a good effect on the environment in the oral cavity. it can.
以下、本発明の実施の形態を説明する。
Hereinafter, embodiments of the present invention will be described.
本発明は、マウスピース内に、乳酸菌を生きた状態で入れてから当該マウスピースを歯又は歯茎に装着することにより、マウスピース内で乳酸菌を培養する方法による歯のホワイトニング方法である。
The present invention is a tooth whitening method by culturing lactic acid bacteria in a mouthpiece by putting the lactic acid bacteria in a living state in the mouthpiece and then attaching the mouthpiece to the teeth or gums.
現在、多くの歯科医院で顎関節治療・ホワイトニング・矯正治療等で使用されているマウスピースがある。図１は、このようなマウスピースの一例を示す概略の斜視図であり、図２は、マウスピースを装着した状態での図１のＸ－Ｘ線に対応する部分の断面図である。図示のマウスピース１は、対象者（被施術者）の歯列１１および歯肉１２を覆うように口腔内の所定位置に装着可能な平面視Ｕ字状の中空部材であって、図２に示すように、その開口部周縁部１Ａが歯頸部歯肉ライン（歯列と歯肉との境目にライン）よりも若干歯茎（歯肉）１２側（図２の下方）へと延びている。したがって、マウスピース１は歯茎１２に密着させた状態で装着することができる。
Currently, there are mouthpieces used in temporomandibular joint treatment, whitening, orthodontic treatment, etc. in many dental clinics. FIG. 1 is a schematic perspective view showing an example of such a mouthpiece, and FIG. 2 is a cross-sectional view of a portion corresponding to X-rays in FIG. 1 with the mouthpiece attached. The illustrated mouthpiece 1 is a hollow member having a U-shape in a plan view that can be attached to a predetermined position in the oral cavity so as to cover the tooth row 11 and the gingiva 12 of the subject (the person to be treated), and is shown in FIG. As described above, the peripheral edge 1A of the opening extends slightly toward the gingiva (gingiva) 12 side (lower part of FIG. 2) from the cervical gingival line (the line at the boundary between the dentition and the gingiva). Therefore, the mouthpiece 1 can be attached in close contact with the gum 12.
マウスピース１は、ポリエチレン、ポリカーボネート、エチレンビニルアセテート（ＥＶＡ）などの熱可塑性樹脂によって構成されている。また、マウスピース１の作製手順については、下記で説明する。
The mouthpiece 1 is made of a thermoplastic resin such as polyethylene, polycarbonate, and ethylene vinyl acetate (EVA). The procedure for manufacturing the mouthpiece 1 will be described below.
すなわち、上記のマウスピース１は、歯列１１の全体及び歯茎１２の一部を覆うことができる形状に形成されている。今回は、マウスピース１内に、乳酸菌を生きた状態で入れてから当該マウスピース１を装着することにより、マウスピース１内で乳酸菌を培養する方法を発案した。
That is, the mouthpiece 1 is formed in a shape capable of covering the entire dentition 11 and a part of the gum 12. This time, we devised a method of culturing lactic acid bacteria in the mouthpiece 1 by putting the lactic acid bacteria in the mouthpiece 1 in a living state and then attaching the mouthpiece 1.
具体的な手法は、下記の通りである。
［手法］
下記の手順〔１〕～〔８〕をこの順番に行う。なお、手順〔３〕と手順〔８〕は歯のホワイトニングの効果測定に用いるもので、本発明の歯のホワイトニング方法には必須の手順ではないため、省略が可能である。 The specific method is as follows.
[Method]
The following steps [1] to [8] are performed in this order. Since the procedure [3] and the procedure [8] are used for measuring the effect of tooth whitening and are not essential for the tooth whitening method of the present invention, they can be omitted.
［手法］
下記の手順〔１〕～〔８〕をこの順番に行う。なお、手順〔３〕と手順〔８〕は歯のホワイトニングの効果測定に用いるもので、本発明の歯のホワイトニング方法には必須の手順ではないため、省略が可能である。 The specific method is as follows.
[Method]
The following steps [1] to [8] are performed in this order. Since the procedure [3] and the procedure [8] are used for measuring the effect of tooth whitening and are not essential for the tooth whitening method of the present invention, they can be omitted.
〔１〕対象者の口腔内印象を印象材にて取り、石膏模型を作製する。
〔２〕石膏模型にマウスピース用シートを加熱密着させ、歯茎部分を密着させた形状のマウスピースを作製する。
〔３〕ホワイトニング前の歯のシェード（明度）を測定する。
〔４〕マウスピースの内部にまんべんんなく唾液（対象者本人の唾液）を滴下又は塗布する。
〔５〕マウスピースの内部に滴下又は塗布した唾液上に乳酸菌顆粒を散布、もしくは乳酸菌剤を混合する。
〔６〕マウスピースを対象者の歯及び歯茎に装着する。
〔７〕口唇を閉じてそのままの状態で数時間放置する。もしくはそのまま就寝して一晩放置する。
〔８〕マウスピースを外し、ホワイトニング後の歯のシェードを測定する。 [1] The impression of the subject's oral cavity is taken with an impression material, and a plaster model is prepared.
[2] A mouthpiece sheet is heated and brought into close contact with the plaster model to prepare a mouthpiece having a shape in which the gums are brought into close contact with each other.
[3] The shade (brightness) of the tooth before whitening is measured.
[4] Drop or apply saliva (saliva of the subject) evenly to the inside of the mouthpiece.
[5] Lactic acid bacteria granules are sprayed or mixed with a lactic acid bacterium agent on saliva dropped or applied to the inside of the mouthpiece.
[6] The mouthpiece is attached to the subject's teeth and gums.
[7] Close the lips and leave it as it is for several hours. Or just go to bed and leave it overnight.
[8] Remove the mouthpiece and measure the tooth shade after whitening.
〔２〕石膏模型にマウスピース用シートを加熱密着させ、歯茎部分を密着させた形状のマウスピースを作製する。
〔３〕ホワイトニング前の歯のシェード（明度）を測定する。
〔４〕マウスピースの内部にまんべんんなく唾液（対象者本人の唾液）を滴下又は塗布する。
〔５〕マウスピースの内部に滴下又は塗布した唾液上に乳酸菌顆粒を散布、もしくは乳酸菌剤を混合する。
〔６〕マウスピースを対象者の歯及び歯茎に装着する。
〔７〕口唇を閉じてそのままの状態で数時間放置する。もしくはそのまま就寝して一晩放置する。
〔８〕マウスピースを外し、ホワイトニング後の歯のシェードを測定する。 [1] The impression of the subject's oral cavity is taken with an impression material, and a plaster model is prepared.
[2] A mouthpiece sheet is heated and brought into close contact with the plaster model to prepare a mouthpiece having a shape in which the gums are brought into close contact with each other.
[3] The shade (brightness) of the tooth before whitening is measured.
[4] Drop or apply saliva (saliva of the subject) evenly to the inside of the mouthpiece.
[5] Lactic acid bacteria granules are sprayed or mixed with a lactic acid bacterium agent on saliva dropped or applied to the inside of the mouthpiece.
[6] The mouthpiece is attached to the subject's teeth and gums.
[7] Close the lips and leave it as it is for several hours. Or just go to bed and leave it overnight.
[8] Remove the mouthpiece and measure the tooth shade after whitening.
なお、上記の手順〔１〕～〔８〕のうち、マウスピースの作製に関する〔１〕、〔２〕手順は一例であり、マウスピースとしては、対象者の歯及び歯茎の一部を覆い、かつ歯茎に密着させた状態で装着することができるマウスピースが望ましく、そのようなものであれば、上記以外の他の手法で作製したものであっても構わない。
Of the above procedures [1] to [8], the procedures [1] and [2] relating to the production of the mouthpiece are examples, and the mouthpiece covers a part of the subject's teeth and gums. A mouthpiece that can be worn in close contact with the gums is desirable, and as long as it is such a mouthpiece, it may be manufactured by a method other than the above.
要は、装着した際に歯茎部分に密着することでマウスピース内にある程度の密封空間を形成でき、その密封空間内に唾液と乳酸菌を混合したものを封入することができる手法であればよい。この場合、マウスピース内に塗布する唾液によってマウスピースと歯茎の隙間はある程度は密封された状態となるため、乳酸菌が死滅しない程度の嫌気的条件を満たすことができれば、マウスピースは歯茎に厳密に密着するものでなくても構わない。
The point is that any method can be used as long as it is possible to form a certain sealing space in the mouthpiece by adhering to the gum part when it is attached, and to enclose a mixture of saliva and lactic acid bacteria in the sealing space. In this case, the gap between the mouthpiece and the gums is sealed to some extent by the saliva applied to the mouthpiece, so if the anaerobic conditions that do not kill the lactic acid bacteria can be met, the mouthpiece will be strictly attached to the gums. It does not have to be in close contact.
また、手順〔５〕で塗布する乳酸菌顆粒又は乳酸菌剤に含まれる乳酸菌としては、例えば、ラクトバチルス・ロイテリ、ラクトバチルス・サリバリウス、エンテロコッカス・フェカリス、ケフィアグレイン、クリスパタス菌に含有される乳酸菌等が挙げられる。これらから選ばれる１種を単独で又は２種以上を組み合わせて使用することができる。
Examples of the lactic acid bacterium contained in the lactic acid bacterium granules or the lactic acid bacterium agent applied in the procedure [5] include lactic acid bacteria contained in Lactobacillus reuteri, Lactobacillus salivarius, Enterococcus faecalis, kefir grain, and Crispatus bacterium. Be done. One type selected from these can be used alone or in combination of two or more types.
口腔内善玉菌の多くが偏性嫌気性菌または通性嫌気性菌であり、繁殖するには嫌気的条件下が望ましい。歯科治療で使用されている多くのマウスピースは、歯とマウスピースの間に唾液が入ることによって、乳酸菌に代表される口腔内善玉菌にとっては必然的に嫌気的条件を満たすことになる。また、口腔内は約３７度を保ち、マウスピース内の唾液は「唾液培地」として乳酸菌の繁殖に大いに寄与することは明白な事実である。フリーズドライ化した一種の仮眠状態である乳酸菌は、マウスピース内で唾液と接触することで一気に増殖を始める。
Most of the good bacteria in the oral cavity are obligate anaerobes or facultative anaerobes, and anaerobic conditions are desirable for reproduction. Many mouthpieces used in dental treatment inevitably satisfy anaerobic conditions for good oral bacteria such as lactic acid bacteria due to saliva entering between the teeth and the mouthpiece. In addition, it is a clear fact that the temperature in the oral cavity is maintained at about 37 degrees, and the saliva in the mouthpiece contributes greatly to the growth of lactic acid bacteria as a "saliva medium". Lactic acid bacteria, which are a kind of freeze-dried nap, start to grow at once when they come into contact with saliva in the mouthpiece.
ロイテリキンに代表される乳酸菌は、近年、バクテリオシンという抗菌物質を出すことが分かり、齲蝕病原菌と歯周病原菌の除去に非常に有効であることが分かった。さらに、今回、本願の発明者は、乳酸菌が出す乳酸とプロテアーゼは、歯の着色物質をマイルドに溶解し、歯のホワイトニング効果があることを発見した。ロイテリキン・クリスパタス菌といった乳酸菌は、生菌で口腔内応用することで、口腔内培養が可能である。そのまま、一定時間置くことで、十分な歯のホワイトニング効果があり、さらには、歯の表面を覆っているペリクルは勿論、プラーク（バイオフィルム）まで除去することができる。つまり、この乳酸菌を用いた歯のホワイトニングは、歯を白くするだけではなく、虫歯と歯周病の予防から治療への応用まで可能にする、画期的な発明と言える。
In recent years, lactic acid bacteria represented by reuterikin have been found to produce an antibacterial substance called bacteriocin, and have been found to be extremely effective in removing caries pathogens and periodontal pathogens. Furthermore, this time, the inventor of the present application has discovered that lactic acid and protease produced by lactic acid bacteria mildly dissolve tooth coloring substances and have a tooth whitening effect. Lactic acid bacteria such as Reuterikin and Crispatus can be cultured in the oral cavity by applying them as live bacteria in the oral cavity. By leaving it as it is for a certain period of time, it has a sufficient tooth whitening effect, and further, plaque (biofilm) as well as plaque covering the tooth surface can be removed. In other words, tooth whitening using this lactic acid bacterium can be said to be an epoch-making invention that not only whitens teeth but also enables prevention and treatment of tooth decay and periodontal disease.
また、この乳酸菌を用いた歯のホワイトニングは、元来口腔内にいた善玉菌を用いることで、非常に生体親和性が高く、安全なホワイトニングシステムが可能となる。こういった意味で、この乳酸菌を用いた歯のホワイトニング（バイオホワイトニング）は、非常に有益性が高く、今までに類を見ないホワイトニングシステムとなり得る。今後、更なる研究が進み、上記の乳酸菌として、ホワイトニングにより適した微生物が発見されることであろう。
In addition, tooth whitening using this lactic acid bacterium has extremely high biocompatibility and enables a safe whitening system by using the good bacteria that were originally in the oral cavity. In this sense, tooth whitening (bio-whitening) using this lactic acid bacterium is extremely beneficial and can be an unprecedented whitening system. Further research will be carried out in the future, and as the above-mentioned lactic acid bacteria, microorganisms more suitable for whitening will be discovered.
〔実施例〕
本願の発明者は、上記の歯のホワイトニング方法に関する試験を行った。以下、その試験方法及び試験結果について説明する。 〔Example〕
The inventor of the present application has conducted a test on the above-mentioned tooth whitening method. The test method and test results will be described below.
本願の発明者は、上記の歯のホワイトニング方法に関する試験を行った。以下、その試験方法及び試験結果について説明する。 〔Example〕
The inventor of the present application has conducted a test on the above-mentioned tooth whitening method. The test method and test results will be described below.
＜試験方法＞
〔１〕対象者の歯のシェード（明度）を測色計で測定する（before）。ここでは、上下顎４番（右側）から４番（左側）を対象とする。
〔２〕対象者の歯型石膏模型に、マウスピース用シート０．８ｍｍを加熱密着させ、簡易的なマウスピースを作成する。
〔３〕夕食後、歯ブラシによる歯磨きをしてから、マウスピース内に乳酸菌粉（生菌）を適量散布する（マウスピースの凹みが埋まる程度）。
〔４〕残りの乳酸菌粉末を対象者の舌下に入れて約２分間放置する。
〔５〕唾液と混合された乳酸菌混合液をマウスピース内に滴下する。
〔６〕マウスピースを口腔内に装着する。
〔７〕そのまま就寝する。（約８時間）
〔８〕その後、マウスピースを外して、歯のシェードを測定する（after1）。
〔９〕翌日も上記〔１〕～〔８〕と同じ手順を行い、再度歯のシェードを測定する（after2）。 <Test method>
[1] The shade (brightness) of the subject's teeth is measured with a colorimeter (before). Here, the upper and lower jaws No. 4 (right side) to No. 4 (left side) are targeted.
[2] A simple mouthpiece is prepared by heat-adhering a mouthpiece sheet 0.8 mm to the subject's tooth-shaped plaster model.
[3] After dinner, brush the teeth with a toothbrush, and then spray an appropriate amount of lactic acid bacteria powder (live bacteria) into the mouthpiece (to the extent that the dents in the mouthpiece are filled).
[4] Put the remaining lactic acid bacterium powder under the tongue of the subject and leave it for about 2 minutes.
[5] A lactic acid bacterium mixed solution mixed with saliva is dropped into the mouthpiece.
[6] The mouthpiece is placed in the oral cavity.
[7] Go to bed as it is. (About 8 hours)
[8] After that, the mouthpiece is removed and the shade of the tooth is measured (after1).
[9] On the next day, the same procedure as in [1] to [8] above is performed, and the tooth shade is measured again (after2).
〔１〕対象者の歯のシェード（明度）を測色計で測定する（before）。ここでは、上下顎４番（右側）から４番（左側）を対象とする。
〔２〕対象者の歯型石膏模型に、マウスピース用シート０．８ｍｍを加熱密着させ、簡易的なマウスピースを作成する。
〔３〕夕食後、歯ブラシによる歯磨きをしてから、マウスピース内に乳酸菌粉（生菌）を適量散布する（マウスピースの凹みが埋まる程度）。
〔４〕残りの乳酸菌粉末を対象者の舌下に入れて約２分間放置する。
〔５〕唾液と混合された乳酸菌混合液をマウスピース内に滴下する。
〔６〕マウスピースを口腔内に装着する。
〔７〕そのまま就寝する。（約８時間）
〔８〕その後、マウスピースを外して、歯のシェードを測定する（after1）。
〔９〕翌日も上記〔１〕～〔８〕と同じ手順を行い、再度歯のシェードを測定する（after2）。 <Test method>
[1] The shade (brightness) of the subject's teeth is measured with a colorimeter (before). Here, the upper and lower jaws No. 4 (right side) to No. 4 (left side) are targeted.
[2] A simple mouthpiece is prepared by heat-adhering a mouthpiece sheet 0.8 mm to the subject's tooth-shaped plaster model.
[3] After dinner, brush the teeth with a toothbrush, and then spray an appropriate amount of lactic acid bacteria powder (live bacteria) into the mouthpiece (to the extent that the dents in the mouthpiece are filled).
[4] Put the remaining lactic acid bacterium powder under the tongue of the subject and leave it for about 2 minutes.
[5] A lactic acid bacterium mixed solution mixed with saliva is dropped into the mouthpiece.
[6] The mouthpiece is placed in the oral cavity.
[7] Go to bed as it is. (About 8 hours)
[8] After that, the mouthpiece is removed and the shade of the tooth is measured (after1).
[9] On the next day, the same procedure as in [1] to [8] above is performed, and the tooth shade is measured again (after2).
＜試験結果＞
図３は、上記試験の結果を示す表である。同図の表には、対象者１と対象者２のそれぞれにおいて、歯のホワイトニングを行う前（before）と、歯のホワイトニングを行った後（after1,after2）の測色計で測定した歯の明度、及びその変化を数値で示している。この表に示すように、本発明にかかる歯のホワイトニング方法を行うことによる歯の明度の改善には明確な効果が認められることがわかった。なお、対象者１は、３６歳女性であり、対象者２は、３９歳女性である。 <Test result>
FIG. 3 is a table showing the results of the above tests. The table in the figure shows the teeth measured with a colorimeter before and after tooth whitening (after1, after2) in each ofsubject 1 and subject 2. The brightness and its change are shown numerically. As shown in this table, it was found that a clear effect was observed in the improvement of tooth brightness by performing the tooth whitening method according to the present invention. The subject 1 is a 36-year-old woman, and the subject 2 is a 39-year-old woman.
図３は、上記試験の結果を示す表である。同図の表には、対象者１と対象者２のそれぞれにおいて、歯のホワイトニングを行う前（before）と、歯のホワイトニングを行った後（after1,after2）の測色計で測定した歯の明度、及びその変化を数値で示している。この表に示すように、本発明にかかる歯のホワイトニング方法を行うことによる歯の明度の改善には明確な効果が認められることがわかった。なお、対象者１は、３６歳女性であり、対象者２は、３９歳女性である。 <Test result>
FIG. 3 is a table showing the results of the above tests. The table in the figure shows the teeth measured with a colorimeter before and after tooth whitening (after1, after2) in each of
従来の歯のホワイトニング方法では、必ずしも歯の明度が上がらないことがしばしば起こりえるが、本発明にかかるホワイトニング方法での明度上昇の確実性は目を見張るものがある。実際に、対象者（被験者）からは、「口の中がさっぱりして歯がつるつるしている」「歯が乳白色になった」といった声があがった。これは、乳酸菌の口腔内病原菌の殺菌作用によるものと、乳酸菌の産生するポリリン酸による歯のコーティングに起因すると予測される。痛みの発現も一切なく、化学薬品によらない天然由来の安心・安全な歯のホワイトニング方法と言える。
It often happens that the brightness of teeth does not always increase with the conventional tooth whitening method, but the certainty of the increase in brightness with the whitening method according to the present invention is remarkable. In fact, the subjects (subjects) said that their mouths were refreshing and their teeth were slippery, and that their teeth became milky white. It is predicted that this is due to the bactericidal action of oral pathogens of lactic acid bacteria and the coating of teeth with polyphosphoric acid produced by lactic acid bacteria. There is no pain at all, and it can be said that it is a safe and secure tooth whitening method derived from nature that does not rely on chemicals.
Claims (3)
- 下記の手順〔１〕～〔４〕を含むことを特徴とする歯のホワイトニング方法。
〔１〕口腔内の歯及び歯茎の一部に装着可能なマウスピースの内部に対象者本人の唾液を塗布する。
〔２〕前記マウスピースの内部に塗布した唾液上に乳酸菌顆粒を散布、もしくは乳酸菌剤を混合する。
〔３〕前記マウスピースを対象者の歯及び歯茎に装着する。
〔４〕その状態で、口唇を閉じて少なくとも数時間放置する。 A tooth whitening method comprising the following steps [1] to [4].
[1] The subject's saliva is applied to the inside of the mouthpiece that can be attached to a part of the teeth and gums in the oral cavity.
[2] Lactic acid bacteria granules are sprayed or mixed with a lactic acid bacterium agent on saliva applied to the inside of the mouthpiece.
[3] The mouthpiece is attached to the subject's teeth and gums.
[4] In that state, close the lips and leave it for at least several hours. - 前記マウスピースは、対象者の歯茎部分に密着させた形状である
ことを特徴とする請求項１に記載の歯のホワイトニング方法。 The tooth whitening method according to claim 1, wherein the mouthpiece has a shape that is in close contact with the gum portion of the subject. - 前記マウスピースの作製方法として、更に下記の手順〔５〕、〔６〕を前記手順〔１〕～〔４〕の前に行うことを特徴とする請求項２に記載の歯のホワイトニング方法。
〔５〕対象者の口腔内印象を印象材にて取り、当該口腔内の石膏模型を作製する。
〔６〕前記石膏模型にマウスピース用シートを加熱密着させ、対象者の歯茎部分に密着させた形状のマウスピースを作製する。 The tooth whitening method according to claim 2, wherein as a method for producing the mouthpiece, the following procedures [5] and [6] are further performed before the procedures [1] to [4].
[5] The impression of the oral cavity of the subject is taken with an impression material, and a plaster model of the oral cavity is prepared.
[6] A mouthpiece sheet is heated and brought into close contact with the gypsum model to prepare a mouthpiece having a shape in which the mouthpiece is brought into close contact with the gum portion of the subject.
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| JP2019-181547 | 2019-10-01 | ||
| JP2019181547 | 2019-10-01 |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011524364A (en) * | 2008-06-13 | 2011-09-01 | オラジェニックス，インコーポレイテッド | Use of hydrogen peroxide producing bacteria to whiten teeth |
| WO2012153765A1 (en) * | 2011-05-09 | 2012-11-15 | Ueda Tomokazu | Multilayer mouthpiece, manufacturing method and manufacturing device thereof |
| JP2016214817A (en) * | 2015-05-15 | 2016-12-22 | 友和 上田 | Dental mouthpiece set and mouthpiece |
| JP2018521136A (en) * | 2015-07-17 | 2018-08-02 | エービー−バイオティクス，エス．エイ． | Self-film forming composition for oral care |
| JP2020111524A (en) * | 2019-01-09 | 2020-07-27 | 三井化学株式会社 | Dental drug delivery system agent and dental drug delivery system instrument |
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2020
- 2020-10-01 WO PCT/JP2020/037417 patent/WO2021066094A1/en active Application Filing
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011524364A (en) * | 2008-06-13 | 2011-09-01 | オラジェニックス，インコーポレイテッド | Use of hydrogen peroxide producing bacteria to whiten teeth |
| WO2012153765A1 (en) * | 2011-05-09 | 2012-11-15 | Ueda Tomokazu | Multilayer mouthpiece, manufacturing method and manufacturing device thereof |
| JP2016214817A (en) * | 2015-05-15 | 2016-12-22 | 友和 上田 | Dental mouthpiece set and mouthpiece |
| JP2018521136A (en) * | 2015-07-17 | 2018-08-02 | エービー−バイオティクス，エス．エイ． | Self-film forming composition for oral care |
| JP2020111524A (en) * | 2019-01-09 | 2020-07-27 | 三井化学株式会社 | Dental drug delivery system agent and dental drug delivery system instrument |
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