WO2021060191A1

WO2021060191A1 - Variable magnetic field generation device

Info

Publication number: WO2021060191A1
Application number: PCT/JP2020/035494
Authority: WO
Inventors: 穣川上; 仁支神谷; 開大和; 愛伯耆原
Original assignee: ピップ株式会社
Priority date: 2019-09-26
Filing date: 2020-09-18
Publication date: 2021-04-01
Also published as: CN114555182A

Abstract

The variable magnetic field generation device (1) according to the embodiments comprises a magnetic body (2), a drive unit (3), and a housing (4). The drive unit (3) moves the magnetic body (2) and thereby generates a variable magnetic field. The housing (4) houses the magnetic body (2) and the drive unit (3). The variable magnetic field that is generated from the magnetic body (2) as a result of the magnetic body (2) being moved by the drive unit (3) reduces the vibration of bioactive ions inside cells.

Description

Fluctuating magnetic field generator

An embodiment of the present invention relates to a fluctuating magnetic field generator.

Smooth muscle reacts via specific receptors such as various in vivo substances, neurotransmitters, autacoids, hormones, etc., causing contraction or relaxation. Smooth muscles are roughly divided into visceral smooth muscles, vascular smooth muscles, and ocular smooth muscles, and their locations are the digestive system (esophagus, stomach, small intestine, large intestine, gallbladder, bile duct), trachea, bronchi, sperm tract, seminal vesicles, The vasculature of the uterus, trachea, arteries and veins, etc. are diverse. They play important roles in digestion, respiration, reproduction, circulation, thermoregulation, and focal light regulation.

Smooth muscle also exhibits functions and associated morphology that are specific to each organ. Then, smooth muscle causes contraction and relaxation as described above by a wide variety of substances, and even if the same substance is used, the reaction may be reversed depending on the type of smooth muscle.

For example, uterine smooth muscle is controlled by both sympathetic and parasympathetic nerves, but in humans, the response to parasympathetic excitement is unchanged, and the response to sympathetic excitement is relaxation in the non-pregnant uterus and contraction in the pregnant uterus. Occur.

Further, the cell in the present invention may be any cell as long as it is a cell that expresses a physiologically active ion vibration or a calcium vibration reaction in the cell, and is not particularly limited, but for example, a mesenchymal cell other than a smooth muscle cell. This applies to lineage cells. Membrane cells are a group of cells composed of cells derived from mesophyll or outer lung lobe (nerve ridge), and mainly form fetal connective tissues, such as chondrogenic cells, osteoblastic nerve cells, and glial cells. It has the ability to differentiate into various cells such as cutaneous pigment cells, adrenal medulla cells, mesenchymal cells such as bone and cartilage, and vascular smooth muscle cells.

Therefore, smooth muscle cells such as vascular smooth muscle, bladder smooth muscle, and uterine smooth muscle, mesenchymal stem cells, osteoblasts, immune cells, nerve cells, and the like are preferable, and vascular smooth muscle and bladder smooth muscle are particularly preferable. -Smooth muscle cells such as uterine smooth muscle or mesenchymal stem cells, more preferably vascular smooth muscle cells.

Various reactions occur when smooth muscle contracts and relaxes. Focusing on this point, it is useful for the treatment of various diseases by using a drug that acts on smooth muscle, which has the effect of changing the state of smooth muscle contraction and relaxation. Has been done. In addition, drugs are used for the purpose of affecting the differentiation and function of mesenchymal cells, regulating their differentiation and function, and controlling diseases.

Japanese Unexamined Patent Publication No. 2011-162554

However, drug treatment often has different effects depending on the patient's condition, and there are concerns about side effects. In addition, the drug itself used may be contraindicated for the patient. Therefore, while drug treatment is often effective, it may be used in a limited number of situations.

The present invention has been made to solve the above problems, and an object of the present invention is to directly suppress physiologically active ion vibration by using a fluctuating magnetic field, for example, in the case of smooth muscle, smooth muscle. It is an object of the present invention to provide a fluctuating magnetic field generator capable of removing obstacles caused by contraction of a magnetic field.

Further, an object of the present invention is not only when the cell is used by being attached to the user's skin, but also, for example, by directly applying magnetism to the isolated cell, the expression of bioactive ion vibration and calcium vibration reaction in the cell is confirmed. It is an object of the present invention to provide a fluctuating magnetic field generator that can also be used in such cases.

The fluctuating magnetic field generator in the embodiment includes a magnetic material, a driving unit, and a housing. The drive unit generates a fluctuating magnetic field by moving the magnetic material. The housing accommodates the magnetic material and the drive unit. It is characterized in that vascular smooth muscle suppresses the contraction of blood vessels by reducing the vibration of bioactive ions in cells due to the fluctuating magnetic field generated by the driving unit moving the magnetic material.

Moreover, it is preferable that the physiologically active ion is a calcium ion.

Further, the cells are preferably smooth muscle cells or mesenchymal cells.

Further, it is preferable that the magnetic poles of the plurality of magnetic parts included in the magnetic material all have the same magnetic pole orientation.

Further, it is preferable that the magnetic material has magnetic portions indicating the directions of a plurality of magnetic poles different from each other.

Further, the magnetic material has fluidity, and it is preferable that the driving unit generates a fluctuating magnetic field by moving the magnetic material so as to circulate in the peripheral circuit.

Further, when the magnetic material is configured to be rotatable by the drive unit, the drive unit preferably rotates the magnetic material at a rotation speed of 500 rotations or more per minute.

Further, the fluctuating magnetic field generator in the embodiment includes a magnetic material, a magnetic shield material, a drive unit, and a housing. The magnetic shield material partially blocks the magnetism of the magnetic material. The drive unit rotates the magnetic shield material. The housing houses the magnetic material, the magnetic shield material, and the drive unit. Then, when the magnetic material is fixed, the drive unit generates a fluctuating magnetic field by rotating the magnetic shield material.

Further, it is preferable that the magnetic shield material has a gap through which a fluctuating magnetic field passes.

Further, it is preferable that the magnetic shield material is provided with a portion through which a fluctuating magnetic field is passed and is composed of a material having a low magnetic shield property.

Further, it is preferable that the drive unit rotates the magnetic shield material at a rotation speed of 500 rotations or more per minute.

It is preferable that the magnetic material is arranged at a position within about 13 mm from the object to which the fluctuating magnetic field generator is mounted.

The fluctuating magnetic field generator according to the embodiment further comprises a plate having a chamber in which the cells are placed, and the magnetic material rotates around an axis vertically penetrating the placement surface around the cells placed in the chamber. It is preferable to move on a plane parallel to the mounting surface.

In addition, it is preferable that one or more rooms are provided on the plate.

The fluctuating magnetic field generator according to the embodiment further comprises a plate having a chamber in which the cells are placed, and a plurality of magnetic materials are arranged at positions facing each other across the cells, and the cells placed in the chamber are provided with a plurality of magnetic materials. It is preferable to rotate the axis parallel to the mounting surface and common to a plurality of magnetic materials as a rotation axis.

It is preferable that the plurality of magnetic materials all rotate in the same direction.

It is preferable that one room is provided on the plate.

Since the present invention employs such a configuration, smooth muscle is smoothed by directly suppressing physiologically active ion vibration using a fluctuating magnetic field, for example, in the case of smooth muscle, by suppressing contraction of smooth muscle. It is possible to provide a fluctuating magnetic field generator capable of removing obstacles caused by muscle contraction.

In addition, it should be used not only when it is attached to the user's skin, but also when, for example, the expression of physiologically active ion vibration or calcium vibration reaction in the cell is confirmed by directly applying magnetism to the isolated cell. It is possible to provide a fluctuating magnetic field generator capable of

It is sectional drawing which shows the whole structure of the fluctuation magnetic field generator in 1st Embodiment. It is a schematic diagram which shows an example of the magnetic material in 1st Embodiment. It is a schematic diagram which shows an example of the magnetic material in 1st Embodiment. It is a schematic diagram which shows an example of the magnetic material in 1st Embodiment. It is a waveform diagram which shows the effect when the fluctuating magnetic field is applied to the user by using the fluctuating magnetic field generator in the 1st Embodiment. It is a top view which shows the whole structure of the fluctuation magnetic field generator in 2nd Embodiment. It is a top view which shows the whole structure of the variable magnetic field generator which is the 1st modification of the variable magnetic field generator in 2nd Embodiment. It is a top view which shows the whole structure of the fluctuating magnetic field generator which is the 2nd modification of the fluctuating magnetic field generator in the 2nd Embodiment.

Hereinafter, the embodiment will be described in detail with reference to the drawings.

(First Embodiment)
[Configuration of fluctuating magnetic field generator]
FIG. 1 is a cross-sectional view showing the overall configuration of the fluctuating magnetic field generator 1 according to the first embodiment. As shown in FIG. 1, the fluctuating magnetic field generator 1 according to the first embodiment of the present invention is used by being attached to the skin S of the user. The fluctuating magnetic field generator 1 shown in FIG. 1 shows a state of being attached to the skin S.

By using the fluctuating magnetic field generator 1 attached to the user's skin S in this way, the generated fluctuating magnetic field is applied to the skin S and various parts of the body in the vicinity of the surface of the skin S.

The position to which the fluctuating magnetic field generator 1 is attached is not particularly limited, and any position such as the skin of the neck, shoulders, abdomen, and waist can be used as long as the effect of the fluctuating magnetic field can be utilized. May be good.

The fluctuating magnetic field generator 1 includes a magnetic body 2, a drive unit 3, and a housing 4. As described above, FIG. 1 shows a state of being attached to the skin S of a user who uses the fluctuating magnetic field generator 1. In this case, the housing 4 in the fluctuating magnetic field generator 1 comes into direct contact with the skin S.

Further, although the magnetic body 2 and the driving unit 3 are housed inside the housing 4, the magnetic body 2 is arranged at a position closer to the skin S, and faces the skin S on the upper portion, that is, with the magnetic body 2 sandwiched between them. The drive unit 3 is arranged at such a position.

Further, in FIG. 1, a shaft 5 connecting the magnetic body 2 and the drive unit 3 is shown, which is for the drive unit 3 to rotate the disk-shaped magnetic body 2 as an example of the magnetic body 2. The axis of rotation is shown.

Note that in FIG. 1, neither the magnetic body 2 nor the driving unit 3 shows the details thereof. This is because, as will be described later, the magnetic material 2 and the driving unit 3 can adopt various arrangements, shapes, modes, and the like.

The magnetic body 2 is moved by the drive unit 3 described later to generate a fluctuating magnetic field. In the present specification, the term "fluctuation magnetic field" means that the direction and intensity of the magnetic field fluctuate.

Further, in the embodiment of the present invention, the "magnetic material" can be magnetized regardless of the mode of a solid, a fluid, or a mode of use (for example, a magnet, a magnetic fluid, etc.). It means a substance, a mechanism, or a structure. A structure containing a plurality of magnets or a structure including an electromagnet may be used.

That is, the magnetic material 2 may be, for example, a magnet, an electromagnet, or a magnetic fluid (magnetic fluid). Further, for example, when the magnetic body 2 is a magnet, any material may be used as long as the magnetic body 2 has magnetism such as ferrite, neodymium, samarium-cobalt, alnico, iron chromium cobalt, and iron platinum.

The number of magnetic materials 2 may be singular or plural. For example, when the magnetic body 2 is formed in a disk shape, there is only one magnetic body 2, and the magnetic body 2 can be used by rotating it with its center as a rotation axis. Further, it may be configured to generate a fluctuating magnetic field by moving a plurality of magnetic materials 2 in combination.

Further, regarding the magnetic poles of the plurality of magnetic parts included in the magnetic body 2, even if they have the same pole (the direction of the same magnetic poles such as N pole and N pole or S pole and S pole), they have different poles (N pole and S). It does not matter whether it is a pole or a direction of different magnetic poles such as an S pole and an N pole). This is because the reaction in each part inside the user is very fast when a fluctuating magnetic field is applied.

That is, for example, when the magnetic body 2 is formed in a disk shape as described above and is rotated by the drive unit 3, for example, the first magnetic pole, the second magnetic pole, the third magnetic pole, and the Nth magnetic pole. In addition, a fluctuating magnetic field due to a plurality of magnetic poles can be continuously applied to the inside of the user.

In this case, the reaction in each part inside by the fluctuating magnetic field given by the first magnetic pole ends before the fluctuating magnetic field is given by the next second magnetic pole. Then, this phenomenon also ends before the fluctuating magnetic field given by the third magnetic pole is applied to the reaction in the fluctuating magnetic field given by the second magnetic pole.

Therefore, it does not matter whether the continuous magnetic poles that give the fluctuating magnetic field are the same magnetic poles or different magnetic poles, and the continuous magnetic poles that give the fluctuating magnetic field may be the same pole or different poles.

Also, regarding the arrangement of the magnetic material 2, any arrangement can be adopted. 2 to 4 are schematic views showing an example of various arrangements, shapes, and modes of the magnetic body 2 in the fluctuating magnetic field generator 1 according to the first embodiment.

However, preferably, the magnetic material 2 is arranged so that the axis connecting the magnetic poles is substantially perpendicular to the bottom surface of the housing 4 (the surface in contact with the skin S of the user). By arranging in this way, the magnetic pole direction of the magnetic body 2 extends substantially perpendicular to the bottom surface of the housing 4 (the surface of the skin S). Therefore, as compared with the case of using a magnetic material whose magnetic pole direction extends parallel to the bottom surface (the surface of the skin S), the magnetic field strength in the direction substantially perpendicular to the surface of the skin S becomes larger, and the magnetic field strength is increased from the surface of the skin S. Magnetism will act deeper into the body.

FIG. 2 shows a magnetic body 2A formed in a disk shape. A rotating shaft 5 that receives a driving force from the driving unit 3 is provided at the center of the magnetic body 2A, and connects the magnetic body 2A and the driving unit 3.

In the magnetic material 2A of FIG. 2, two N poles and S poles are arranged so as to appear alternately with each other. However, as described above, the continuous magnetic poles are not limited to different poles and may be the same pole.

The magnetic body 2B shown in FIG. 3 adopts a shape in which two magnetic bodies formed in a rod shape are combined so as to be orthogonal to each other. A rotating shaft 5 that receives a driving force from the driving unit 3 is also provided at the center of the magnetic body 2B, and connects the magnetic body 2B and the driving unit 3.

In the magnetic body 2B shown in FIG. 3, the magnetic poles are not displayed, but as described above, the continuous magnetic poles may be either different poles or the same poles.

Unlike the

magnetic bodies

2A and 2B described so far, the magnetic body 2C shown in FIG. 4 is characterized in that it is composed of a magnetic fluid having fluidity, not a magnet as a solid. The magnetic body 2C includes a circulation pipe 2C2 for holding and circulating the magnetic fluid 2C1 inside, and a pump 2C3 for circulating the magnetic fluid 2C1 in the circulation pipe 2C2.

The magnetic body 2C is arranged at a position closest to the user's skin S inside the housing 4, and the magnetic fluid 2C1 circulates in the circulation pipe 2C2 by the pump 2C3 to give a fluctuating magnetic field to the inside of the skin S. ..

The magnetic body 2C here is formed so that the circulation pipe 2C2 draws a circumferential circuit so that the magnetic fluid 2C1 can circulate inside the circulation pipe 2C2.

In this way, the magnetic material 2 not only generates a fluctuating magnetic field by rotating as described above, but also linearly moves the magnetic fluid 2C1 so as to flow in the circulation pipe 2C2 as shown in FIG. A fluctuating magnetic field may be generated.

The arrangement of the circulation pipe 2C2 shown in FIG. 4 is merely an example. Instead of the arrangement as shown in FIG. 4, for example, the circulation pipe 2C2 may be folded back or meandered to be arranged so that the moving distance of the magnetic body 2 can be lengthened.

Although not described with reference to the drawings, the magnetic material 2 may be, for example, an electromagnet. When the magnetic body 2 is an electromagnet, a fluctuating magnetic field is applied to the inside of the user by receiving a power supply from a direct current or an alternating current power source. Further, in this case, a control unit for controlling the magnetic body 2 which is an electromagnet may be provided.

As described above, the magnetic material 2 may adopt any arrangement, shape, and mode as described above as long as it is in a mode of generating a fluctuating magnetic field.

The drive unit 3 generates a fluctuating magnetic field by moving the magnetic body 2. For example, when the magnetic body 2 is rotatably configured as described above, the drive unit 3 can adopt a mechanism that adds rotation to the magnetic body 2 via the shaft 5.

As a mechanism for adding rotation, for example, a mechanism such as a motor or a royal fern can be considered. Further, in adding the rotation, the motor or the like may directly rotate the magnetic body 2, or a mechanism for transmitting the rotation by using a pulley, a gear or the like may be adopted.

When the drive unit 3 is, for example, a motor, it is necessary to keep a sufficient distance between the motor and the magnetic body 2 in order to exert the effect of the magnetic body 2. This distance can be secured by adjusting the length of the shaft 5.

When the magnetic body 2 is the magnetic fluid 2C1, the pump 2C3 is used as described above. The drive unit 3 circulates the magnetic fluid 2C1 in the circulation pipe 2C2 by driving the pump 2C3.

Although it has been described so far that the drive unit 3 rotates the magnetic body 2, for example, the magnetic body 2 is fixed inside the housing 4, and the drive unit 3 has, for example, a fluctuating magnetic field. It may be configured to give a fluctuating magnetic field to the user by rotating a shielding plate such as that provided by the unit.

For example, a magnetic shield material provided with a gap can be rotated around a fixed magnetic material to partially block the magnetism of the magnetic material, thereby changing the shielding position and generating a fluctuating magnetic field. Here, as the magnetic shield material, for example, permalloy can be used.

Further, the magnetic shield material may be provided with a portion made of a material having a low magnetic shield property, for example, as a part of the magnetic shield material instead of the gap. By rotating such a magnetic shield material around the magnetic material, a fluctuating magnetic field can be generated through a portion of the material having a low magnetic shield property.

As shown in FIG. 1, the housing 4 accommodates the magnetic body 2 and the driving unit 3 in its internal space. The housing 4 has an upper surface and a side surface surrounding the internal space, and a bottom surface that comes into contact with the skin S when the fluctuating magnetic field generator 1 is attached to the skin S. In the embodiment of the present invention, for example, the fluctuating magnetic field generator 1 is provided with a known adhesive sheet provided on the bottom surface of the housing 4 so that the bottom surface indirectly contacts the skin S of the user. It is pasted on.

Regarding the shape of the housing 4, if an internal space having a size capable of movably accommodating the magnetic material 2 is formed and the housing 4 has a bottom surface in contact with the skin S of the user, for example, it is substantially cylindrical. , It may be formed in any shape such as a substantially prismatic shape.

Further, the molding material of the housing 4 is not particularly limited as long as the shape of the internal space can be maintained when a force is received from the outside and the magnetic field lines of the magnetic body 2 can be easily transmitted. Therefore, for example, synthetic resin materials such as acrylonitrile butadiene styrene (ABS), polycarbonate acrylonitrile butadiene styrene (PC-ABS), polyethylene (PE) and polyethylene terephthalate (PET) can be preferably used.

It should be noted that, for example, the drive unit 3 moves the magnetic body 2 to generate a fluctuating magnetic field, and notifies the input unit and the user who operate the fluctuating magnetic field generator 1 of the state in which the fluctuating magnetic field generator 1 is operating. Although the output unit and the like are actually provided, the drawing thereof is omitted in the fluctuating magnetic field generator 1 shown in FIG.

For example, the input unit is composed of various switches, knobs, etc., such as a switch for turning on the power, and accepts various input operations by the user. As the input unit, in addition to such a switch, various types of input devices such as a GUI (Graphical User Interface) or a button can be used.

Further, as described above, for example, in the case of a mechanism in which the drive unit 3 uses a royal fern, a crown or the like around which the royal fern is wound can be included in the input unit.

On the other hand, as the output unit, for example, a lamp or the like indicating an operating state such as ON or OFF of the fluctuating magnetic field generator 1 to the user can be mentioned. It should be noted that the output unit may be not only one that appeals to the user visually, but also one that appeals to the five senses such as hearing.

[motion]
Next, with reference to FIG. 5, the operation of the fluctuating magnetic field generator 1 and the effect brought about by the movement of the magnetic material 2 will be described below. FIG. 5 is a waveform diagram showing an effect when a fluctuating magnetic field is applied to a user by using the fluctuating magnetic field generator 1 according to the first embodiment.

First, taking the dilation and contraction of blood vessels as an example, the general operation mechanism of cells when an external stimulus is given will be explained. For example, when an external stimulus is applied to a blood vessel, it affects the intracellular calcium ions inside the vascular endothelial cells and vascular smooth muscle cells.

When intracellular calcium ions in vascular endothelial cells rise due to external stimuli, they act to promote vasodilation. On the other hand, when intracellular calcium ions in vascular smooth muscle cells are elevated by an external stimulus, they act to promote the contraction of blood vessels.

However, in the vasodilation-promoting action of vascular endothelial cells, the action of intracellular calcium ions in vascular endothelial cells activates nitric oxide synthase, and the produced nitric oxide moves to vascular smooth muscle cells. , Acts to suppress vasoconstriction of vascular smooth muscle cells.

Looking at the appearance of the vascular relaxing action based on external stimuli in the vascular endothelial cells and the vascular smooth muscle cells, the vascular smooth muscle cells appear and converge earlier than the reaction by the vascular endothelial cells.

Let's take a look at the waveform diagram in Fig. 5. The waveform diagram shows the results of adding a fluorescence indicator that detects physiologically active ions to the collected vascular smooth muscle cells, applying a fluctuating magnetic field, and observing the reaction using a fluorescence microscope. ..

In the waveform diagram, the horizontal axis shows time. On the other hand, the vertical axis shows the bioactive ion concentration converted from the fluorescence intensity. The higher this value, the higher the concentration of intracellular bioactive ions. This leads to the promotion of blood vessel constriction in vascular smooth muscle cells. Therefore, it can be equated with the occurrence of vasoconstriction of vascular smooth muscle cells.

On the other hand, a low value indicates that the concentration of intracellular bioactive ions is low. When the concentration of intracellular bioactive ions is low, the action of vasoconstriction in vascular smooth muscle cells is suppressed, and conversely, the action of vasodilation in vascular endothelial cells is strongly exhibited. That is, when the concentration of intracellular physiologically active ions becomes low, a state in which blood vessels are relaxed becomes apparent.

Also, in the waveform diagram, a vertical line is drawn in the part of 900 seconds. The vertical line is a line that separates whether or not a fluctuating magnetic field is applied to the user's body by the fluctuating magnetic field generator 1. That is, the fluctuating magnetic field is not applied to the left side of the vertical line, that is, before 900 seconds. On the other hand, a fluctuating magnetic field is applied to the right side of the vertical line after 900 seconds.

Before the fluctuating magnetic field is applied by the fluctuating magnetic field generator 1, intracellular bioactive ions act on vascular smooth muscle cells, and the concentration of intracellular bioactive ions fluctuates, resulting in contraction of blood vessels. Is caused as a time average.

However, after 900 seconds when the fluctuating magnetic field was applied to the blood vessels of the user by the fluctuating magnetic field generator 1, the concentration of intracellular bioactive ions decreased as compared with before the fluctuating magnetic field was applied.

If there is no change in the concentration of intracellular bioactive ions regardless of whether a fluctuating magnetic field is applied, the waveform shown by the broken line in FIG. 5 should appear. However, after the fluctuating magnetic field is applied as described above, the concentration of intracellular physiologically active ions decreases. This means that the blood vessels do not contract and the relaxed state is maintained.

From the above, when the fluctuating magnetic field is applied by the fluctuating magnetic field generator 1, the periodic fluctuation (vibration) that the concentration of the intracellular bioactive ion fluctuates is reduced (disappeared), and the intracellular bioactive ion is reduced (disappeared). The concentration is kept low.

In addition, the fact that the blood vessels do not contract and continue to relax means that the given fluctuating magnetic field acts directly on the vascular smooth muscle cells, and it is considered that the action of vasoconstriction by the vascular smooth muscle cells is inhibited. be able to. Inhibition of the action of vasoconstriction results in a state of vasodilation.

Therefore, in a state where a fluctuating magnetic field is applied by the fluctuating magnetic field generator 1, the state of vasodilation continues, and when the blood vessels are dilated, blood circulation is improved, and for example, blood flow is improved.

The operation of the fluctuating magnetic field generator 1 when the vibration of intracellular bioactive ions in such vascular smooth muscle cells is suppressed and the state in which the concentration of intracellular bioactive ions is kept low is maintained is as follows. is there.

The fluctuating magnetic field generator 1 according to the embodiment of the present invention does not necessarily require that the magnetic poles of the magnetic body 2 have different poles. As described above, the reaction in each part inside the user by the fluctuating magnetic field given by one magnetic pole ends before the fluctuating magnetic field is given by the next magnetic pole. Therefore, the magnetic poles of the magnetic material 2 may be the same pole or different poles.

Further, the number of revolutions given to the magnetic body 2 by the drive unit 3 is, for example, 500 revolutions per minute or more. This is because, as a result of the experiment, it is known that the effect of suppressing the vibration of the physiologically active ion is exhibited by rotating the magnetic material 2 at a rotation speed of 500 rotations or more per minute by the driving unit 3. Further, the upper limit of the number of revolutions can be set to, for example, 6500 revolutions per minute.

Similarly, the number of revolutions given to the magnetic shield material by the drive unit 3 is, for example, 500 revolutions per minute or more.

Further, the magnetic material 2 is arranged at a position as close to the user's skin S as possible. This is because the closer the magnetic body 2 is to the skin S to which the fluctuating magnetic field generator 1 is attached, the more reliably the strength of the fluctuating magnetic field that gives the fluctuating magnetic field to each part of the user's body can be increased. Specifically, in the fluctuating magnetic field generator 1 according to the embodiment of the present invention, the magnetic material 2 is arranged at a position within approximately 1 mm to 13 mm from the surface where the fluctuating magnetic field generator 1 contacts the skin S of the user. (See reference numeral H in FIG. 1).

According to at least one embodiment described above, since the fluctuating magnetic field generator 1 according to the embodiment of the present invention adopts the above-described configuration, the smooth muscle contracts directly using the fluctuating magnetic field. By suppressing the smooth muscle, it is possible to eliminate the disorder caused by the contraction of the smooth muscle.

By applying a fluctuating magnetic field to the vascular smooth muscle cells in this way, the action of the vascular smooth muscle cells to contract can be inhibited. Therefore, in a state where a fluctuating magnetic field is applied, the blood vessel can be maintained in a relaxed (dilated) state without contracting. Therefore, it can be expected to improve blood circulation and improve various diseases.

Furthermore, by applying a fluctuating magnetic field, it is possible to suppress the contraction of blood vessels and manifest a relaxed state, which means that the concentration of intracellular bioactive ions is temporary for some reason while the fluctuating magnetic field is applied. Even if there is, it is possible to reduce the occurrence of a high phenomenon.

(Second Embodiment)
Next, a second embodiment of the present invention will be described. In the second embodiment, the same components as those described in the first embodiment described above are designated by the same reference numerals, and the description of the same components will be omitted because they are duplicated.

[Configuration of fluctuating magnetic field generator]
FIG. 6 is a plan view showing the overall configuration of the fluctuating magnetic field generator 11 according to the second embodiment. Further, FIG. 7 is a plan view showing the overall configuration of the fluctuating magnetic field generator 12, which is a first modification of the fluctuating magnetic field generator 11 in the second embodiment. Further, FIG. 8 is a plan view showing the overall configuration of the fluctuating magnetic field generator 13, which is a second modification of the fluctuating magnetic field generator 11 in the second embodiment.

The fluctuating magnetic field generator 11 to the fluctuating magnetic field generator 13 according to the second embodiment shown in FIGS. 6 to 8 can be used to generate bioactive ion vibrations in the cells by directly applying magnetism to the isolated cells, for example. It is used to confirm the expression of the calcium vibration reaction. Therefore, unlike the fluctuating magnetic field generator 1 in the first embodiment described above, it is not used by being attached to the skin S of the user.

That is, the fluctuating magnetic field generator in the second embodiment is used when observing cells placed in a room provided on a plate, for example, with a microscope. More specifically, the cells to be observed are housed in these fluctuating magnetic field generators, and the fluctuating magnetic field generator is fixed to a microscope for observation.

First, in the fluctuating magnetic field generator 11 shown in FIG. 6, a plate P1 on which a cell to be observed is placed is arranged in a substantially central portion of a rectangular housing. Here, the plate P1 is provided with a plurality of chambers R for accommodating cells. The plate P1 shown in FIG. 6 is provided with four rooms R1 to R4.

However, it is sufficient that the plate P1 is provided with a plurality of rooms R, and the number thereof is not particularly limited. In the following, when each room is collectively described, it is appropriately referred to as “room R”.

The plate P1 is provided with four rooms R1 to R4 having a columnar shape, for example, so as to stand on a plate-shaped bottom surface. The cells to be observed are housed in the rooms R1 to R4.

In this way, the cells are housed and observed inside the room R, but the cells actually housed in the room R spread widely and thinly in the room R and exist in a form of sticking to the bottom surface thereof. Become. Therefore, the state in which the cells are housed in the room R is appropriately expressed as "the cells are placed in the room".

The plate P1 is housed inside the fluctuating magnetic field generator 11 during observation. That is, in the fluctuating magnetic field generator 11, the accommodating portion 11a of the plate P1 is provided. Here, the accommodating portion 11a is formed in a columnar shape so that the outer shape of the plate P1 is formed in a circular shape.

Here, the method of fixing the plate P1 in the accommodating portion 11a is not particularly limited. Even if it is fixed by being connected between the bottom surface of the plate P1 and the accommodating portion 11a by some mechanism, or by pressing the upper surface of the plate P1 downward in the vertical direction, the plate P1 is fixed in the accommodating portion 11a. You can do it.

A plurality of magnetic materials 21 are arranged on the side wall portion of the accommodating portion 11a. That is, when the plate P1 is placed on the accommodating portion 11a, the magnetic body 21 surrounds the plate P1. In the fluctuating magnetic field generator 11 shown in FIG. 6, four magnetic bodies 21a to 21d are arranged so as to be orthogonal to each other.

As described above, four magnetic bodies 21 are arranged here, but the number of the magnetic bodies 21 to be arranged does not matter. For example, two or six magnetic materials 21 may be arranged, or one annular magnetic material 21 may be used. Further, when a plurality of magnetic materials 21 are arranged, the arrangement position and the north pole and the south pole may be different.

Further, these four magnetic bodies 21a to 21d are housed in one annular magnetic body accommodating portion 11b. Therefore, the magnetic body 21a to the magnetic body 21d can be integrally moved by rotating the magnetic material accommodating portion 11b. The variable magnetic field generator 11 according to the second embodiment adopts the following configuration as a configuration for rotating the magnetic material accommodating portion 11b.

That is, the gear 11c is provided on the upper surface of the magnetic material accommodating portion 11b and in the circumferential shape thereof. The gear 11c is connected to the drive unit 31 and meshes with a gear that transmits the rotation thereof, and is capable of receiving a driving force from the drive unit 31. Therefore, the magnetic material accommodating portion 11b can rotate under the power of the driving portion 31.

Due to this movement, the plurality of magnetic bodies 21a to 21d are parallel to the mounting surface around the cells placed in the chambers R1 to R4, with the axis perpendicularly penetrating the placement surface of the cells as the rotation axis. It will move on the surface and give the cell a fluctuating magnetic field.

In the fluctuating magnetic field generator 11 according to the embodiment of the present invention, the gear 11c is directly provided on the magnetic material accommodating portion 11b in this way, but the magnetic material accommodating portion receives the driving force from the driving unit 31. As long as 11b can rotate around the cell and apply a fluctuating magnetic field to the cell, its structure is not limited.

Next, a modified example of the above-mentioned fluctuating magnetic field generator 11 will be described by taking the fluctuating magnetic field generator 12 shown in FIG. 7 as an example. The fluctuating magnetic field generator 12, which is the first modification, is the same as the fluctuating magnetic field generator 11 in that the magnetic material rotates around the cell to give the cell a fluctuating magnetic field in response to a driving force from the driving unit. However, its structure is different.

That is, first, the plate P2 used in the fluctuating magnetic field generator 12 is provided with only one room R. This room R5 is provided in the central portion of the plate P2, and cells to be observed are housed (placed) in the chamber R5.

The structure of the room R5 itself is the same as the room R1 to the room R4 provided on the plate P1 described above. However, the plate P2 is different from the room R1 or the room R4 provided in the plate P1 in that the plate P2 includes only one room R5 and its arrangement position is also in the central portion. Further, since the plate P2 adopts such a configuration, a space is secured between the side wall of the room R5 and the peripheral edge of the plate P2.

And the space is used as a space to accommodate the magnetic material. In the fluctuating magnetic field generator 12, as shown by the broken line in FIG. 7, four magnetic bodies 21e to 21h are arranged so as to be orthogonal to each other around the room R5.

In the first modification, since the space is secured between the side wall of the chamber R5 and the peripheral edge of the plate P2 in this way, the magnetic material 21e to the magnetic material 21h used in the fluctuating magnetic field generator 12 is A magnetic material larger than the magnetic material 21a to the magnetic material 21d used in the above-mentioned fluctuating magnetic field generator 11 is used. Since such a large magnetic material can be used, the fluctuating magnetic field generator 12 can apply a larger magnetic force to the cell than the fluctuating magnetic field generator 11.

In the fluctuating magnetic field generator 12, four magnetic bodies 21e to 21h are arranged around the room R5, but the number of magnetic materials, the arrangement position, or the distinction between N pole and S pole is determined. It can be set freely.

Further, in the fluctuating magnetic field generator 11, four magnetic bodies 21a to 21d are housed in the magnetic material accommodating portion 11b already provided in the fluctuating magnetic field generator 11. On the other hand, since the magnetic body 21e to the magnetic body 21h in the fluctuating magnetic field generator 12 is larger than the magnetic body 21a to the magnetic body 21d in the fluctuating magnetic field generator 11, in relation to the shape, size, and arrangement position of the plate P2. , It is arranged so as to cover it from the upper part of the plate P2.

That is, when observing cells using the fluctuating magnetic field generator 12, first, the plate P2 provided with the room R5 on which the cells are placed is placed in the accommodating portion 12a of the fluctuating magnetic field generator 12. To. Since the room R5 provided on the plate P2 is provided in the central portion thereof, a space is formed between the room R5 and the side wall of the accommodating portion 12a.

As described above, the magnetic material 21e or the magnetic material 21h will be arranged in this space, but since the plate P2 is placed on the accommodating portion 12a, it cannot be arranged at this position from the beginning. Therefore, the magnetic material accommodating portion 12b in which the magnetic material 21e to the magnetic material 21h is accommodated is arranged in the accommodating portion 12a so as to cover the plate P2 from above.

Here, the magnetic material accommodating portion 12b arranged in the accommodating portion 12a is fixed to the fluctuating magnetic field generator 12 by using bolts or the like. However, the fixing method of the magnetic material accommodating portion 12b is not limited to such a fixing method, and various fixing methods can be adopted.

Since the magnetic material accommodating portion 12b is arranged in the accommodating portion 12a so as to cover the plate P2 in this way, it is possible to observe the cells placed in the chamber R5 depending on the shape adopted by the magnetic material accommodating portion 12b. It is possible that you cannot do it. Therefore, a through hole 12c is provided in the central portion of the magnetic material accommodating portion 12b in the fluctuating magnetic field generator 12. By providing the through hole 12c, the cells placed in the chamber R5 provided in the central portion of the plate P2 can be observed with a microscope.

The magnetic material accommodating portion 12b can rotate around the room R5 of the plate P2. In the fluctuating magnetic field generator 12, a gear 12d is provided around the magnetic material accommodating portion 12b, and the gear 12d meshes with a gear connected to the driving portion 31 to generate a driving force from the driving unit 31. It is possible to receive it.

Therefore, the magnetic material accommodating portion 12b rotates under the power of the driving unit 31. By this movement, the magnetic material 21e to the magnetic material 21h can rotate around the room R in which the cells are placed to apply a fluctuating magnetic field to the cells.

The gear 12d provided around the magnetic material accommodating portion 12b is formed wider than the gear 11c provided in the magnetic material accommodating portion 11b of the fluctuating magnetic field generator 11. This is because the magnetic material 21e to the magnetic material 21h used in the fluctuating magnetic field generator 12 is larger than the magnetic material 21a to the magnetic material 21d used in the fluctuating magnetic field generator 11, and the magnetic material accommodating portion 12b accommodating these magnetic materials. This is because a larger driving force is required to rotate the magnet.

Next, a second modification of the above-mentioned fluctuating magnetic field generator 11 will be described by taking the fluctuating magnetic field generator 13 shown in FIG. 8 as an example. The fluctuating magnetic field generator 13, which is a second modification, is a fluctuating magnetic field generator 11 or a fluctuating magnetic field generator in that the magnetic material rotates in response to a driving force from the driving unit to give a fluctuating magnetic field to cells. It is the same as 12, but its structure and the method of rotating the magnetic material are different.

The plate P3 used in the fluctuating magnetic field generator 13 is provided with one room R6 in the central portion thereof, like the plate P2. The cells to be observed are placed inside this room R6.

On the other hand, the arrangement position and the direction of rotation of the magnetic material are different from those of the fluctuating magnetic field generator 11 and the fluctuating magnetic field generator 12 so far. That is, the magnetic body 21i and the magnetic body 21j used in the fluctuating magnetic field generator 13 are arranged at positions opposite to each other with the room R6 on which the cells are placed as shown in FIG. That is, unlike the magnetic material used in the fluctuating magnetic field generator 11 and the fluctuating magnetic field generator 12, it does not rotate around the cell to give a fluctuating magnetic field.

The magnetic body 21i and the magnetic body 21j in the second modification have their rotation axes as the axes in the longitudinal direction of the magnetic body 21i and the magnetic body 21j, respectively. Therefore, the magnetic body 21i and the magnetic body 21j do not rotate around the cell, but the magnetic body 21i and the magnetic body 21j do not move their positions and rotate around the axis in the longitudinal direction at the arrangement position.

As described above, the magnetic body 21i and the magnetic body 21j are arranged at positions facing each other with the room R6 in between. Then, when the magnetic body 21i in the fluctuating magnetic field generator 13 in the second modification is cut in the lateral direction and the cross section is viewed, for example, the upper half is the north pole and the lower half is the lower half. Is set to be the S pole.

That is, in such a case, the upper half becomes the north pole and the lower half becomes the south pole when cut so as to pass through the rotation axis in the longitudinal direction. When the magnetic body 21i is in such a state, the magnetic body 21j located at a position facing the room R6 is arranged so that the lower half is the north pole and the upper half is the south pole. That is, when the magnetic material 21i and the magnetic material 21j face each other with the room R6 in between, the different poles face each other.

Regarding the arrangement of the N pole and the S pole in the magnetic material 21i and the magnetic material 21j, in addition to the case where they are arranged in the upper and lower halves as described above, for example, the cross section is viewed by cutting in the lateral direction. In this case, the north pole and the south pole may be arranged so as to be staggered in the circumferential direction, and the arrangement position is not limited. Further, when the magnetic material 21i and the magnetic material 21j face each other across the room R6, the same poles may be arranged so as to face each other.

Here, in the fluctuating magnetic field generator 13 in the second modification, the driving unit 31 is configured to transmit the driving force to each of the magnetic body 21i and the magnetic body 21j located at positions facing each other across the room R6. ing. That is, in the fluctuating magnetic field generator 13, the drive unit 31 is composed of a first drive unit 311 for driving the magnetic body 21i and a second drive unit 312 for driving the magnetic body 21j.

However, as shown in FIG. 8, only one mechanism for adding rotation is provided, and the driving force from this one mechanism is a gear that penetrates the first driving unit 311 and the second driving unit 312. Is transmitted to the magnetic body 21i and the magnetic body 21j via. Since the fluctuating magnetic field generator 13 has such a structure, the magnetic body 21i and the magnetic body 21j rotate in the same direction by the driving force from the driving unit 31.

In this way, since the magnetic material 21i and the magnetic material 21j are arranged at positions facing each other with the cell sandwiched between them, the cells placed in the chamber R6 are arranged on an axis parallel to the cell placement surface. Therefore, the axis common to the magnetic body 21i and the magnetic body 21j is used as a rotation axis to rotate.

Moreover, these magnetic materials 21i and 21j are arranged so that different poles face each other when they face each other with the room R6 in between. From these facts, a fluctuating magnetic field can be effectively applied to the cells placed in the room R6.

In this way, the magnetic material 21i and the magnetic material 21j in the second modification are arranged so that different poles face each other. For example, the same poles face each other, or one of the magnetic materials faces the north pole. A magnetic material having an S pole as the magnetic material may be adopted and arranged.

Further, a part of the magnetic body 21i and the magnetic body 21j in the fluctuating magnetic field generator 13 is covered with the magnetic body cover 22. As described above, the magnetic body 21i and the magnetic body 21j rotate about the longitudinal direction thereof as a rotation axis. However, since the magnetic body 21i and the magnetic body 21j have a certain weight, it is conceivable that the rotation axes of the magnetic body 21i and the magnetic body 21j may shift due to their own weights. If the rotation axis deviates, it is possible that the magnetic body 21i and the magnetic body 21j come into contact with the surrounding structures. Therefore, the rotation axis is maintained by the magnetic body cover 22.

Further, depending on the strength of the magnetic force of the magnetic body 21i and the magnetic body 21j, there is a possibility of affecting the surrounding mechanism. Therefore, by covering the magnetic body 21i and the magnetic body 21j with the magnetic body cover 22, the influence of the magnetic force is prevented from affecting other mechanisms.

As described in the first embodiment, a mechanism such as a motor or a royal fern can be considered as the drive unit 31 in the fluctuating magnetic field generator according to the second embodiment. Further, the arrangement position of the drive unit 31 in the fluctuating magnetic field generator 11 to the fluctuating magnetic field generator 13 is merely an example, and the arrangement position can be any position.

Regarding the shape of the housing 4, as long as an internal space having a size capable of movably accommodating the magnetic material 2 is formed, the shape may be, for example, substantially cylindrical or substantially prismatic. It may be formed. Further, the molding material of the housing 4 is not particularly limited as long as the shape of the internal space can be maintained when a force is received from the outside.

Since the fluctuating magnetic field generator 11 to the fluctuating magnetic field generator 13 according to the embodiment of the present invention described above employs the above-described configuration, for example, the intracellular physiological activity by directly applying magnetism to the isolated cells. The expression of ionic vibration and calcium vibration reaction can be confirmed.

Although some embodiments of the present invention have been described, these embodiments are presented as examples and are not intended to limit the scope of the invention. These embodiments can be implemented in various other embodiments, and various omissions, replacements, and changes can be made without departing from the gist of the invention. These embodiments and modifications thereof are included in the scope and gist of the invention, as well as in the scope of the invention described in the claims and the equivalent scope thereof.

1 Fluctuation magnetic field generator 2 Magnetic material 3 Drive unit 4 Housing 5 Axis 11 to 13 Fluctuation magnetic field generator 21 Magnetic material R room

Claims

With magnetic material
A drive unit that generates a fluctuating magnetic field by moving the magnetic material,
A housing for accommodating the magnetic material and the driving unit is provided.
A fluctuating magnetic field generator characterized in that the generated fluctuating magnetic field reduces the vibration of physiologically active ions in a cell.
The fluctuating magnetic field generator according to claim 1, wherein the physiologically active ion is a calcium ion.
The fluctuating magnetic field generator according to claim 1 or 2, wherein the cell is a smooth muscle cell or a mesenchymal cell.
The fluctuating magnetic field generator according to any one of claims 1 to 3, wherein the magnetic poles of the plurality of magnetic portions included in the magnetic material all have the same magnetic pole orientation.
The fluctuating magnetic field generator according to any one of claims 1 to 3, wherein the magnetic material includes magnetic portions that indicate directions of a plurality of magnetic poles that are different from each other.
Claims 1 to 5, wherein the magnetic material has fluidity, and the driving unit generates the fluctuating magnetic field by moving the magnetic material so as to circulate in a peripheral circuit. The fluctuating magnetic field generator according to any one of.
With magnetic material
A magnetic shield material that partially blocks the magnetism of the magnetic material,
The drive unit that rotates the magnetic shield material and
The magnetic material, the magnetic shield material, and a housing for accommodating the drive unit are provided.
When the magnetic material is fixed,
The driving unit is a fluctuating magnetic field generator characterized in that a fluctuating magnetic field is generated by rotating the magnetic shield material.
The fluctuating magnetic field generator according to claim 7, wherein the magnetic shield material includes a gap through which the fluctuating magnetic field passes.
The fluctuating magnetic field generator according to claim 7, wherein the magnetic shield material includes a portion made of a material having a low magnetic shield property.
The fluctuating magnetic field generator according to any one of claims 7 to 9, wherein the drive unit rotates the magnetic shield material at a rotation speed of 500 rotations or more per minute.
The fluctuating magnetic field generator according to any one of claims 1 to 10, wherein the magnetic material is arranged at a position within 13 mm from the object to which the fluctuating magnetic field generator is mounted.
Further provided with a plate having a room in which the cells are placed,
Claim 1 is characterized in that the magnetic material moves around the cells placed in the chamber on a plane parallel to the above-mentioned mounting surface with an axis perpendicularly penetrating the mounting surface as a rotation axis. The fluctuating magnetic field generator according to any one of claims 5.
The fluctuating magnetic field generator according to claim 12, wherein the room is provided in a single unit or a plurality of the plates.
Further provided with a plate having a room in which the cells are placed,
A plurality of the magnetic materials are arranged at positions facing each other across the cells, and are common to the plurality of magnetic materials with an axis parallel to the mounting surface with respect to the cells placed in the room. The fluctuating magnetic field generator according to any one of claims 1 to 5, wherein the shaft rotates as a rotation axis.
The fluctuating magnetic field generator according to claim 14, wherein the plurality of magnetic materials all rotate in the same direction.
The fluctuating magnetic field generator according to claim 14, wherein the room is provided on the plate.
When the magnetic material is configured to be rotatable by the drive unit,
The fluctuating magnetic field generator according to any one of claims 1 to 6, and 12 to 16, wherein the driving unit rotates the magnetic material at a rotation speed of 500 rotations or more per minute. ..