WO2021039340A1

WO2021039340A1 - Liquid for atomization

Info

Publication number: WO2021039340A1
Application number: PCT/JP2020/030150
Authority: WO
Inventors: 祐輔永松
Original assignee: 日本たばこ産業株式会社
Priority date: 2019-08-30
Filing date: 2020-08-06
Publication date: 2021-03-04
Also published as: JP2022177327A; CN114286627A; EP4023275A4; CN114286627B; EP4023275A1; TW202121994A

Abstract

The present invention provides: a liquid for atomization, said liquid containing an aerosol source that is mainly composed of nicotine, a fatty acid triglyceride, an emulsifying agent and water; and a non-heating flavor inhaler which is provided with a liquid storage part for storing the liquid for atomization, and an atomization part for atomizing the liquid for atomization, said atomization part being not provided with a heating mechanism. The liquid for atomization forms visible smoke which has high visibility that is able to be sustained for a long time.

Description

Atomizing liquid

The present invention relates to an atomizing liquid, and more particularly to an atomizing liquid for a flavor aspirator containing nicotine.

In the non-combustion type flavor aspirator, for example, glycerin, propylene glycol, or water is used as the aerosol source. For example, Patent Document 1 discloses an electronic cigarette that heats a liquid material containing glycerin. Further, Patent Document 2 discloses a non-combustion type flavor aspirator including a capsule containing water, fatty acid triglyceride and a fragrance. The user destroys the capsule and sucks the aroma in the capsule. In this case, the fatty acid triglyceride functions as a diluent for the perfume. In addition, as a liquid material containing fatty acid triglyceride, Patent Document 3 discloses a gastrointestinal smooth muscle peristalsis inhibitor containing water, fatty acid triglyceride and an emulsifier, but there is no suggestion that it contains nicotine and flavor aspiration. Not at all.

By the way, when the non-combustion type flavor aspirator is used, the user tends to obtain a high degree of satisfaction if the visible smoke has high visibility and the visible smoke remains highly visible (high sustainability). It is in. Therefore, there is a demand for a non-combustion type flavor aspirator that has high visibility of visible smoke and can maintain the high visibility.

Japanese Unexamined Patent Publication No. 2018-07902 U.S. Patent Application 2017/064995 Patent No. 4526120

In a non-heated flavor aspirator that uses vibration such as ultrasonic vibration, the aerosol source needs to have a low viscosity from the viewpoint of aerosol generation efficiency, and an aerosol source containing water as a main component is used. However, when the inventors use an aerosol source containing water as a main component, the visibility of visible smoke is lower than when an aerosol source containing glycerin or propylene glycol as a main component is used, and the visible smoke is visible. We have found that due to the short duration of smoke, users may not be fully satisfied. In view of such circumstances, it is an object of the present invention to provide a liquid for atomization capable of forming visible smoke having high visibility of visible smoke and maintaining a state of high visibility for a long time.

The inventors have found that an atomizing liquid containing a water-based aerosol source, nicotine, fatty acid triglyceride, and an emulsifier solves the above-mentioned problems. That is, the above problem is solved by the following invention.
(Aspect 1)
A liquid for atomization containing nicotine, fatty acid triglyceride, an emulsifier, and an aerosol source containing water as a main component.
(Aspect 2)
The atomizing liquid according to aspect 1, wherein the concentration of the nicotine in the atomizing liquid is 5% by weight or less.
(Aspect 3)
The atomizing liquid according to aspect 1 or 2, wherein the concentration of the fatty acid triglyceride in the atomizing liquid is 10% by weight or less.
(Aspect 4)
The atomizing liquid according to any one of aspects 1 to 3, wherein the aerosol source contains 80% by weight or more of water in the aerosol source.
(Aspect 5)
The atomizing liquid according to any one of aspects 1 to 4, wherein the atomizing liquid contains 70% by weight or more of water in the liquid.
(Aspect 6)
The atomizing liquid according to any one of aspects 1 to 5, wherein the fatty acid triglyceride has an aliphatic group derived from a fatty acid and having an aliphatic group having 6 or more carbon atoms.
(Aspect 7)
The atomizing liquid according to any one of aspects 1 to 6, further comprising a fragrance.
(Aspect 8)
A non-heated flavor aspirator comprising a liquid storage unit for storing the atomizing liquid according to aspects 1 to 7 and an atomizing unit for atomizing the atomizing liquid.
(Aspect 9)
The non-heated flavor aspirator according to aspect 8, wherein the atomizing portion includes an atomizing mechanism by vibration.

INDUSTRIAL APPLICABILITY According to the present invention, it is possible to provide an atomizing liquid capable of forming visible smoke having high visibility of visible smoke and having a high visibility state for a long time.

The figure which shows the outline of the atomizing liquid of this invention and the atomized product | The figure which shows one aspect of the non-heated flavor aspirator of this invention The figure explaining the member arranged between the top cover and the bottom cover of the atomizing part. The figure explaining the connection relationship between the atomizing part and the liquid storage part Enlarged view showing an excerpt of a part of the atomized part The figure which shows the measurement method of the duration of visible smoke

Hereinafter, the present invention will be described in detail. In the present invention, "X to Y" includes X and Y which are fractional values thereof.

1. 1. Liquid for atomization (1) Nicotine The origin of nicotine is not limited, but it is preferably derived from tobacco material. Nicotine has the effect of prolonging the visibility of visible smoke formed from the atomizing liquid and the duration of the high visibility of visible smoke. However, if the concentration of nicotine in the atomizing liquid is excessively high, the flavor will be unfavorable. From this point of view, the nicotine concentration in the atomizing liquid is preferably 0.1 to 5% by weight, more preferably 0.5 to 2% by weight.

(2) Fatty acid triglyceride Fatty acid triglyceride is a compound in which a fatty acid is ester-bonded to three hydroxy groups in glycerin, and is represented by the following formula.

R ¹ to R ³ are aliphatic groups derived from fatty acids, and the number of carbon atoms thereof is not limited. ^However, it is preferable that at least one of R 1 ~ ^{R 3} is a group of more than 6 carbon ^atoms, it is preferable that at least two R 1 ~ ^{R 3} is a group of more than 6 carbon ^{atoms, R} 1 ~ R ^{It is more preferable that all of 3} are groups having 6 or more carbon atoms. The upper limit of the number of carbon atoms is not limited, but is preferably 12 or less. If the number of carbon atoms becomes too large, the dispersion stability in the liquid will decrease. From this viewpoint, the carbon number of the three aliphatic groups of the fatty acid triglyceride is preferably in the above range. Fatty acid triglyceride in which all of R ¹ to R ³ are groups having 6 or more carbon atoms is also referred to as medium-chain fatty acid triglyceride. In addition, the medium-chain fatty acid triglyceride has a characteristic that the user does not feel the taste or aroma when smoking.

The concentration of fatty acid triglyceride in the atomizing liquid is not limited, but if the concentration of fatty acid triglyceride is too high, the viscosity of the liquid increases, so atomization is performed in a non-heated flavor aspirator that uses vibration such as ultrasonic vibration. The problem arises that the amount is reduced. From these viewpoints, the upper limit of the concentration in the atomizing liquid is preferably 10% by weight or less, more preferably 5% by weight or less. The lower limit of the concentration is not limited, but is preferably 1% by weight or more, more preferably 2% by weight or more.

(3) Emulsifier The emulsifier has an affinity for both water in the atomizing liquid and the hydrophobic substances nicotine and the fatty acid triglyceride. Known emulsifiers can be used, such as anionic surfactants (eg sodium lauryl sulfate, alkyl ether carboxylates), cationic surfactants (eg benzalconium chloride), amphoteric surfactants (eg amphoteric surfactants) , Lecithin), or nonionic surfactants (eg, polyglycerin fatty acid ester, sucrose fatty acid ester, stearoyl calcium lactate, sorbitan fatty acid ester, propylene glycol fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene sorbitan fatty acid ester, Saponin) and the like can be used. The concentration of the emulsifier in the atomizing liquid is not limited, but is preferably 2% by weight or less, more preferably 1% by weight or less. The lower limit of the concentration is not limited, but is preferably 0.1% by weight or more, more preferably 0.2% by weight or more.

(4) Aerosol Source In the present invention, an aerosol source containing water as a main component is used. The fact that water is the main component means that the aerosol source contains 70% by weight or more of water. The water content is preferably 80% by weight or more based on the total aerosol source. Examples of aerosol sources other than water include glycerin and propylene glycol. These amounts are preferably 30% by weight or less, more preferably 20% by weight or less in the aerosol source. Alternatively, the aerosol source may consist solely of water. Further, it is preferable that water accounts for 70% by weight or more in the atomizing liquid. Since water preferably does not contain impurities, ion-exchanged water or the like can be used.

(5) Other components The atomizing liquid of the present invention may contain a fragrance known in the art. The fragrance is not limited, but examples thereof include menthol. The amount can be a known amount, but is preferably 8% by weight or less, more preferably 5% by weight or less in the atomizing liquid. The lower limit of the concentration is not limited, and other components (fragrances) may not be included. In the present invention, the fragrance does not contain nicotine.

(6) Mechanism The mechanism by which the atomizing liquid can prolong the duration of the visible smoke visibility and the high visibility of visible smoke is not limited, but is presumed as follows. First, as shown in FIG. 1, in the atomizing liquid 1, oil droplets 4 of a hydrophobic substance (nicotine or fatty acid triglyceride) having a low vapor pressure are finely dispersed in an aerosol source 2 containing water as a main component. It is considered to have a structure. The oil droplets are stably present due to the emulsifier 6. Next, the atomizing liquid is atomized to form an atomized product formed by aggregating the particles 1'. In one embodiment, the diameter of the particle 1'is 0.1 to 10 μm, and the diameter of the oil droplet 4 present in the particle 1'is 0.01 to 1 μm. In the particle 1', the oil droplet 4 becomes a nucleus and suppresses the evaporation of the surrounding aerosol source 2. Further, even after the aerosol source 2 evaporates, only the oil droplet 4 stays in place without evaporating because the vapor pressure is low, so that the visibility of visible smoke is improved and the duration of the high state is considered to be long. Be done.

2. 2. Non-heated flavor aspirator The non-heated flavor aspirator includes a liquid storage unit for storing the atomizing liquid and an atomizing unit for atomizing the atomizing liquid, and the flavor contained in the atomizing liquid. It is a device that enables inhalation of ingredients. Therefore, the liquid storage unit is filled with the atomizing liquid before being used. The atomizing unit can be provided with a vibration generating mechanism capable of applying vibration to the atomizing liquid. An atomizing section provided with a vibration generating mechanism is preferable because it has high atomization efficiency. It is preferable that the atomized portion does not have a heating mechanism. By providing an atomizing portion that does not have a heating mechanism, flavor components that are not suitable for heating can be inhaled. The heating mechanism is a mechanism that can atomize the atomizing liquid by itself. For example, the temperature of the liquid given vibration by the vibration generation mechanism may rise, but the vibration generation mechanism in this case does not correspond to the heating mechanism.

Further, the atomized portion may be provided with an auxiliary heating mechanism. The "auxiliary heating mechanism" refers to a heating mechanism that can heat the atomizing liquid but cannot atomize the atomizing liquid by itself. The auxiliary heating mechanism is, for example, a heating mechanism that does not heat the atomizing liquid to its boiling point.

FIG. 2 shows one aspect of the non-heated flavor aspirator. In the figure, 1000 is a non-heated flavor aspirator, 1001D is a mouthpiece, 1100 is an atomizing part, 1200A and 1200B are liquid storage parts, 1202 is a housing, 1102 and 1104 are openings, and 1106 is the top surface of the atomizing part. A cover, 1107 is a bottom cover of the atomized portion, and 1004 is a screw. The

liquid storage units

1200A and 1200B are housed in a storage unit provided in the housing 1202, and the atomizing unit 1100 and the mouthpiece 1001D are connected to the top surface thereof in this order by using screws 1004. As shown in FIG. 2, the atomized portion 1100 is covered by a top cover 1106 of the atomized portion and a bottom cover 1107 of the atomized portion. FIG. 3 is a diagram illustrating a member arranged between the top cover 1106 of the atomized portion and the bottom cover 1107 of the atomized portion in the atomized portion 1100. As shown in FIG. 3, the atomizing unit 1100 includes a PCB board 1109, a piezoelectric element substrate 1031 having a comb-shaped electrode pair 1033, and a pair of

guide walls

1711A and 1711B. Although not shown, a top cover may be arranged above these members, and a base member or the like may be arranged below them. Further, a sensor or a seal member may be arranged between these members and the top cover, if necessary. FIG. 4 is a diagram illustrating a connection relationship between the atomizing section and the liquid storage section. In the figure, for simplification, only the liquid storage unit 1200A is shown, but in reality, the liquid storage unit 1200B is also connected to the atomization unit 1100. As shown in FIG. 4, the liquid storage unit 1200A and the atomization unit 1100 are connected so that the liquid discharge unit provided on the top surface of the liquid storage unit 1200A communicates with the through hole 1713A. FIG. 5 is an enlarged view showing an excerpt of a part of the atomizing portion 1100 shown in FIG. Specifically, in FIG. 5, among the atomizing portions 1100 shown in FIG. 3, the PCB board 1109, the piezoelectric element substrate 1031 provided with the comb-shaped electrode pair 1033, the guide wall 1711A, the sealing member 1111, and the sensor. It shows 1070.

The atomizing unit 1100 has a piezoelectric element substrate 1031 provided with a comb-shaped electrode pair 1033, and is configured to atomize a liquid by a surface acoustic wave (SAW) generated by applying a high-frequency voltage to the comb-shaped electrode pair 1033. Will be done. The surface acoustic waves atomize the atomizing liquid in the

liquid storages

1200A and 1200B, and the atomized material reaches the mouthpiece.

The piezoelectric element substrate 1031 is configured to atomize the liquid by SAW generated by applying a voltage at a high frequency (resonance frequency) to the comb-shaped electrode pair 1033.

The piezoelectric element substrate 1031 includes a piezoelectric body that expands and contracts when a voltage is applied. As the piezoelectric material, a known piezoelectric material composed of a ceramic such as quartz, barium titanate, or lithium niobate can be used.

The comb-shaped electrode pair 1033 is electrically connected to a power source (not shown) provided in the housing 1202 to supply electric power. For example, the comb-shaped electrode pair 1033 is made of gold-plated metal or the like.

The piezoelectric element substrate 1031 has a pair of

edges

1031A and 1031B facing each other. The guide wall 1711A is provided on the edge 1031A side of the piezoelectric element substrate 1031, and the guide wall 1711B is provided on the edge 1031B side. The

guide walls

1711A and 1711B have through holes 1713A and 1713B extending between the upper surface and the lower surface, respectively. Further, the

guide walls

1711A and 1711B have

recesses

1714A and 1714B communicating with the through holes 1713A and 1713B, respectively. As shown in FIG. 4,

liquid storage units

1200A and 1200B are connected to the lower surfaces of the

guide walls

1711A and 1711B, respectively. The atomizing liquid supplied by the syringe pump (not shown) from the

liquid storage units

1200A and 1200B passes through the through holes 1713A and 1713B from the bottom to the top, respectively, and reaches the

recesses

1714A and 1714B, respectively. The liquid that has reached the

recesses

1714A and 1714B reaches the

edges

1031A and 1031B of the piezoelectric element substrate 1031 and is atomized by the energy of the comb-shaped electrode pair 1033. That is, the syringe pump is configured to supply the atomizing liquid to the

edges

1031A and 1031B of the piezoelectric element substrate 1031.

Such a non-heated flavor aspirator is disclosed in, for example, PCT / JP2019 / 0153777. Further, although the figure shows an embodiment in which there are two liquid storage units, there may be one liquid storage unit.

In addition to the one shown in FIG. 2, as a non-heated flavor aspirator, for example, one equipped with an atomizing part having a vibration generating mechanism using ultrasonic vibration can also be used. Such an atomizing portion is used in an ultrasonic nebulizer (for example, NE-U17, NE-U22 manufactured by OMRON Corporation) and the like.

Also, as a non-heated flavor aspirator, one equipped with an atomizing part using a nozzle can be used. The atomizing section includes a liquid storage section, a nozzle for discharging compressed air, and a water absorbing pipe provided adjacent to the nozzle and communicating with the atomizing liquid holding section, and compressed air is discharged from the nozzle. The atomizing liquid is atomized by the pressure difference generated between the nozzle and the water absorption pipe. Such an atomizing part is used in a compressor type nebulizer or the like.

The "non-heated flavor aspirator" in the present invention may be provided with a heating mechanism in a portion other than the atomized portion. For example, in the flavor aspirator of FIG. 2, a heating mechanism for heating the liquid may be provided around the

liquid storage portions

1200A and 1200B, or a heating mechanism may be provided in the flow path of the mouthpiece 1001D.

[Example 1]
As a medium-chain fatty acid triglyceride, 5 g of Kao Corporation's Coconade (registered trademark) MT (C ₈ / C ₁₀ acid triglyceride), 5 g of an emulsifier (Kao's Emazole S-120V), 10 g of nicotine, and 480 g of water are mixed, and a homogenizer (Atec) is used. It was emulsified with Japan's Dostormix BDMM). The obtained liquid was further emulsified using a high-pressure homogenizer (PANDA plus 2000 manufactured by NIRO SOAVI) at a pressure of 50 MPa to obtain a liquid for atomization.

A device as shown in FIG. 6 was prepared. In the figure, 200 is a nebulizer (mesh type nebulizer NE-U22 (manufactured by OMRON Corporation)), 202 is a laser source, 204 is a light receiving part, 206 is a transparent chamber (5 cm × 5 cm × 24 cm), and 208 is a tube. The liquid filling portion of the nebulizer 200 was filled with the atomizing liquid and atomized to generate smoke. The smoke was sucked from above the chamber at a rate of 55 ml / 2 sec for 2 seconds. The laser was irradiated at a position 8.5 cm from the bottom surface of the chamber from the start of suction (after 0 seconds had passed), and the light transmittance of the central part of the chamber 206 was measured after 5 seconds had passed. The light transmission was evaluated using a Malvern Splaytec equipped with a laser source 202 and a light receiving unit 204. However, the light transmittance of the chamber in which smoke does not exist was set to 100%. The results are shown in Table 1. The lower the light transmittance, the higher the visibility of visible smoke. In addition, the light transmittance was continuously measured from the start of suction (after 0 seconds) to 30 seconds, and the total time length of which the light transmittance was 85% or less after 30 seconds (after 0 seconds) ( T) was recorded. The results are shown in Table 1.

[Example 2]
The evaluation was carried out in the same manner as in Example 1 except that the concentration of the medium-chain fatty acid triglyceride was changed as shown in Table 1.

[Example 3]
As the medium chain fatty acid triglyceride, except for using Kao Co. Coconad (TM) RK (C ₈ acid triglyceride), it was evaluated in the same manner as in Example 1.

[Example 4]
The evaluation was carried out in the same manner as in Example 1 except that _{MT-N (C 8} / C ₁₀ acid triglyceride) manufactured by Kao Corporation was used as the medium-chain fatty acid triglyceride.

[Example 5]
The evaluation was carried out in the same manner as in Example 1 except that _{ML (C 8} / C ₁₀ / C ₁₂ acid triglyceride) manufactured by Kao Corporation was used as the medium-chain fatty acid triglyceride.

[Comparative Example 1]
The evaluation was carried out in the same manner as in Example 1 except that the composition of the atomizing liquid was changed as shown in Table 1.

[Comparative Example 2]
The evaluation was carried out in the same manner as in Example 1 except that the composition of the atomizing liquid was changed as shown in Table 1. These results are shown in Table 1.

From the results of Comparative Example 1 and Comparative Example 2, it can be seen that the presence of nicotine reduces the light transmittance (%) 5 seconds after the start of suction. That is, nicotine has the effect of enhancing the visibility of visible smoke. Further, due to the presence of nicotine, the total (T) of the time lengths when the light transmittance was 85% or less is increased. That is, nicotine has an effect of prolonging the duration of a state in which the visibility of visible smoke is high (that is, a state in which the light transmittance is 85% or less).

From the results of Example 1 and Comparative Example 2, it can be seen that the presence of the fatty acid triglyceride reduces the light transmittance (%) 5 seconds after the start of suction. That is, the fatty acid triglyceride has an effect of enhancing the visibility of visible smoke. In addition, the presence of the fatty acid triglyceride lengthens the T. That is, the fatty acid triglyceride has an effect of prolonging the duration of the state in which the visible smoke is highly visible (that is, the state in which the light transmittance is 85% or less).

From the results of Example 1 and Comparative Example 1, it can be seen that the presence of both nicotine and the fatty acid triglyceride significantly reduces the light transmittance (%) 5 seconds after the start of suction. That is, the presence of both nicotine and the fatty acid triglyceride has the effect of greatly enhancing the visibility of visible smoke. Also, the presence of both nicotine and the fatty acid triglyceride significantly lengthens the T. That is, the presence of both nicotine and the fatty acid triglyceride has the effect of significantly prolonging the duration of the highly visible state of visible smoke (that is, the state in which the light transmittance is 85% or less). Furthermore, from the comparison of Examples 2 to 5, it is clear that when the carbon number of the aliphatic group derived from the fatty acid becomes long, the light transmittance (%) decreases and the T becomes long.

1 Atomizing liquid 1'Particle 2 Aerosol source 4 Oil droplet 6 Emulsifier
200 Nebulizer 202 Laser Source 204 Receiver 206 Transparent Chamber 208 Tube
1000 Unheated flavor aspirator 1001D mouthpiece 1004 screw
1033 Comb-shaped electrode pair 1031 Piezoelectric element substrate 1031A, B edge
1100

Atomized part

1102, 1104 Opening 1106 Top surface cover of atomized part 1107 Bottom cover of atomized part 1109 PCB board 1111 Seal member
1200 A, B liquid storage 1202 housing
1711A, B Guide wall 1070 Sensor 1713A, B Through hole 1714A, B Recess

Claims

A liquid for atomization containing nicotine, fatty acid triglyceride, an emulsifier, and an aerosol source containing water as a main component.
The atomizing liquid according to claim 1, wherein the concentration of the nicotine in the atomizing liquid is 5% by weight or less.
The atomizing liquid according to claim 1 or 2, wherein the concentration of the fatty acid triglyceride in the atomizing liquid is 10% by weight or less.
The atomizing liquid according to any one of claims 1 to 3, wherein the aerosol source contains 80% by weight or more of water in the aerosol source.
The atomizing liquid according to any one of claims 1 to 4, wherein the atomizing liquid contains 70% by weight or more of water in the liquid.
The atomizing liquid according to any one of claims 1 to 5, wherein the fatty acid triglyceride has an aliphatic group derived from a fatty acid and having an aliphatic group having 6 or more carbon atoms.
The atomizing liquid according to any one of claims 1 to 6, further comprising a fragrance.
A non-heated flavor aspirator including a liquid storage unit for storing the atomizing liquid according to claims 1 to 7 and an atomizing unit for atomizing the atomizing liquid.
The non-heated flavor aspirator according to claim 8, wherein the atomizing portion includes an atomizing mechanism by vibration.