WO2021031332A1

WO2021031332A1 - Dura mater opening closing apparatus

Info

Publication number: WO2021031332A1
Application number: PCT/CN2019/112815
Authority: WO
Inventors: 江研伟
Original assignee: 江研伟
Priority date: 2019-08-19
Filing date: 2019-10-23
Publication date: 2021-02-25
Also published as: CN112386363A

Abstract

A dura mater opening closing apparatus, comprising an inner support assembly (1), an outer pressing assembly (2), a connection assembly (3), and a package assembly (4). The package assembly (4) comprises a duct (5) structure; the inner support assembly (1), the connection assembly (3), and the outer pressing assembly (2) are disposed in the duct (5) in sequence; the inner support assembly (1) is connected to the outer pressing assembly (2) by means of the connection assembly (3). The apparatus has a simple structure and easy operations; key components are pre-placed in the package assembly (4) and can be easily taken, and the time and labor are saved.

Description

Dural opening closure device

Technical field

The invention relates to a surgical device, in particular to a dural opening closing device, which belongs to the field of medical equipment.

Background technique

In neurosurgery, dura mater injuries generally need to be sutured and anatomically reset, such as dura mater and dura mater injury. However, in endoscopic operations, due to the narrow space of the endoscope, it is too difficult for doctors to manually suture, so most doctors Restoration using plugging materials generally includes the following three types: 1. Packing with gelatin sponge alone; 2. Packing with a combination of medical glue and gelatin sponge; 3. Packing with body fat. Although the above method is simple, it has many problems, including: 1. The effect after packing is not accurate. If the packed gelatin sponge is too loose, it may cause the recurrence of the cerebrospinal fluid after the operation; 2. The packing needs to be artificially designed when combined with glue. The operation is more complicated; 3. If fat packing is used, other parts of the damage need to be increased. There are currently no professional tools on the market for filling dural gaps.

Summary of the invention

In order to simplify the dural closure operation, the present invention provides a convenient dural opening closure device.

One aspect of the present invention provides a hard film opening closing device, which includes an inner support component, an outer compression component, a connection component, and a packaging component. The packaging component includes a pipe. The inner support component, the connection component and the external pressure are sequentially placed in the pipe. Tight component

The inner support component includes an expansion material, the inner support component radially expands from a first structure to a second structure under the action of the expansion material, the inner support component maintains the first structure in the packaging component, and the first structure The perimeter of the inner support component in one structure is smaller than the perimeter of the dural opening; when the inner support component separates from the packaging component and enters the dura opening, it radially expands to the second structure, and the inner support component in the second structure state The circumference of the supporting component is greater than the circumference of the dural opening, so that the inner supporting component contacts and covers the inner surface of the dural opening;

The external compression component includes a memory metal material, and the external compression component is restored from a contracted structure to an expanded structure under the shape memory of the memory metal material; the external compression component is in a contracted structure in the packaging component; The external compression component returns to the expanded structure after being separated from the packaging component. The circumference of the external compression component in the expanded structure state is greater than the circumference of the dural opening, so that the external compression component contacts and covers the dural opening. The outer surface;

The inner support component and the outer compression component are connected by the connection component, the connection component is a wire structure, and the connection component clamps the outer edge of the dura opening between the inner support component and the outer compression component between.

Further, the dural opening closing device further includes a push rod, the push rod is placed in the packaging component, and arranged at the proximal end of the dural opening closing device, and is in contact with the outer pressing component, It is used to push out the external compression component, the connection component and the internal support component from the packaging component, thereby making the operation easier.

Further, the push rod is marked with scale lines along the length direction, so that the pushing distance of the push rod can be accurately controlled, so that the inner support assembly and the outer pressing assembly reach corresponding positions, which is beneficial to the operation of the device.

Further, the distal end of the packaging assembly is made of transparent material, which is convenient for the operator to observe and further confirm that the relevant parts are separated from the tube.

In a preferred embodiment, the swelling material is gelatin sponge, so as to ensure that the inner support component has a relatively good swellability.

Preferably, the inner support component is a composite material composed of a gelatin sponge and a dural patch, the dura patch is arranged on both sides of the gelatin sponge, and the dura patch on one side and the inner dural opening Surface contact, and the circumference of the dura patch is greater than the circumference of the dura opening, so that the dura patch contacts and covers the inner surface of the dura opening. Adding the dura mater on the one hand enhances the bonding effect of the internal support component and the inner surface of the dura opening, and on the other hand supports the gelatin sponge to improve its filling strength.

Further, the dural patch is made of one or more of type I collagen material, pericardial membrane material, polylactic acid material, expanded polytetrafluoroethylene, silk fibroin, medical polyester film or artificial synthetic repair material. Made of a combination of two materials.

Preferably, the dural patch is made of a combination of one or more of the type I collagen material, polylactic acid material or pericardium material.

More preferably, the dural patch is made of type I collagen material.

Further, the dura patch and the gelatin sponge are pasted by a biological protein glue, so that the dura patch and the gelatin sponge adhere more closely.

In another embodiment, the outer pressing component is an umbrella-shaped structure, the inside is arc-shaped, and a threading hole is provided in the middle to connect with the connecting component. The umbrella-shaped structure design makes the external compression component fit more closely with the outer surface of the dural opening, thereby improving the closing effect of the dural opening.

Further, the memory metal material is Nitinol.

Further, the external pressing component further includes a hard film patch, one side of the memory metal material is in contact with the hard film patch, and the other side of the hard film patch contacts and covers the hard film The outer surface of the opening, and the circumference of the dural patch is greater than the circumference of the dural opening. Adding the dura mater makes the external compression component fit more closely to the outer surface of the dura opening.

In another embodiment, the thread structure is made of elastic material. Under the action of the elastic material, the outer edge of the dural opening is more firmly clamped between the inner support component and the outer compression component.

Further, the thread structure is composed of catgut, polylactic acid suture, polyglycolide suture, polyglycolic acid PGA suture, polydioxanone suture, silk thread, nylon suture , Polyester suture or polypropylene suture or a combination of one or more.

Further, the outer edge of the dura mater opening is firmly clamped between the inner support component and the outer pressing component, so that the closed dura mater opening has a waterproof effect.

Further, the inner supporting component, the outer pressing component and the connecting component are all made of biocompatible materials.

In summary, the beneficial effects of the present invention are:

1. The dural opening closing device of the present invention has simple structure and convenient operation. The inner support assembly, the connection assembly and the outer compression assembly are pre-assembled in the packaging assembly, which is convenient for access and saves time and effort.

2. The external compression component of the present invention uses a memory metal material, and under the shape memory of the memory metal material, the external compression component is restored from a contracted structure to an expanded structure, thereby better closing the dural opening.

3. Under the action of the connecting component, the inner support component, the outer pressing component and the dura opening are closer to each other and the effect is better.

4. The push rod is marked with tick marks along the length direction, so that the pushing distance of the push rod can be accurately controlled, which is convenient for operation.

5. The distal end of the package assembly is made of transparent material, which is convenient for the operator to observe and further confirm that the relevant parts are separated from the tube.

6. Adding the dura mater makes the inner support component fit more closely to the inner surface of the dural opening, and at the same time makes the outer compression component fit more closely to the outer surface of the dural opening.

Description of the drawings

By reading the detailed description of the preferred embodiments below, the solutions and advantages of the present application will become clear to those of ordinary skill in the art. The drawings are only used for the purpose of illustrating the preferred embodiments, and are not considered as a limitation to the present invention. In the attached picture:

FIG. 1 is a schematic cross-sectional view of the structure of Embodiment 1 of the present invention.

FIG. 2 is a diagram of the operation steps of Embodiment 1. FIG.

Fig. 3 is a schematic diagram of the Nitinol alloy recovering from the contracted structure to the expanded structure.

Fig. 4 is a top view of the nickel-titanium alloy in the expanded structure state.

Figure 5 is a schematic diagram of the connection between catgut and gelatin sponge.

6 is a schematic cross-sectional view of the structure of Embodiment 2 of the present invention.

Figure 7 is a schematic structural cross-sectional view of the external compression assembly.

FIG. 8 is a diagram of the operation steps of Embodiment 2.

Fig. 9 is a schematic diagram showing the restoration of the external compression assembly from the contracted structure to the expanded structure.

Fig. 10 is a top view of the external pressing assembly in an unfolded configuration state.

Figure 11 is a schematic diagram of the connection between the wire and the inner support assembly.

The above figures: 1. Internal support component; 1-1, Gelatin sponge; 1-2a, dura mater; 1-2b, dura mater; 2. External compression component; 2-1, Nitinol 2-2 Hard film patch; 3. Connecting components; 4. Encapsulating components; 5. Pipes; 6. Push rods.

detailed description

Hereinafter, exemplary embodiments of the present disclosure will be described in more detail with reference to the accompanying drawings. It should be noted that these embodiments are provided for a more thorough understanding of the present disclosure and to fully convey the scope of the present disclosure to those skilled in the art. The present disclosure can be implemented in various forms, which should not be described here. Limited by implementation.

In the description of this application, it should be noted that the directions or positional relationships indicated by the terms "inner", "outer", "top", "bottom", "upper", "lower", etc. are based on the drawings shown The positional relationship is only for the convenience of describing the technical solution claimed in this application and simplified description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a reference to this Limitations of the technical solution claimed in the application

In the description of this application, "wire structure" includes any case of a linear structure, in one embodiment it can be a wire, in another embodiment it can be a rod, preferably made of elastic material In the role of elastic materials, these line structures can have a certain resilience, which can better assist the inner support component and the outer compression component to close the dural opening.

Example 1

1 is a schematic structural cross-sectional view of Embodiment 1 of the dural opening closing device, which includes an inner support component 1, an outer compression component 2, a connection component 3 and a packaging component 4. The packaging component 4 includes a pipe 5 in which an inner supporting component 1, a connecting component 3 and an outer pressing component 2 are placed in sequence, and the inner supporting component 1 and the outer pressing component 2 are connected by the connecting component 3. Among them, the inner support component 1 is a gelatin sponge, and the gelatin sponge is compressed to the first structure in advance, as shown in Figure 1, to ensure that the whole can be fitted into the packaging component 4 and can be pushed into the dural opening during operation. The circumference of the gelatin sponge in a structural state is smaller than the circumference of the dural opening. The external pressing component 2 is made of a memory alloy material, such as Nitinol. The nickel-titanium alloy has an umbrella-shaped structure with a circular arc inside, and a threading hole is opened in the middle to connect with the connecting assembly 3. The nickel-titanium alloy is pre-compressed to a shrinkage structure, as shown in FIG. Here, the connecting component 3 is catgut. Preferably, the distal end of the packaging assembly 4 may be made of a transparent material.

The dural opening closure device may also include a push rod. During operation, the push rod is placed in the packaging assembly 4 and arranged at the proximal end of the dural opening closure device to contact the external pressing assembly 2 for The outer pressing component 2, the connecting component 3 and the inner supporting component 1 are pushed out from the packaging component 4, and the push rod is marked with a scale line along the length direction. It should be noted that the dural opening closure device may not include a push rod. During use, only suitable tools, such as endoscopic surgical instruments, can be used to press the outer compression assembly 2, the connection assembly 3 and the inner support assembly. 1 Push out from the package assembly 4 to complete the closed repair of the hard film.

Figure 2 is a diagram of the operation steps of the dural opening closure device. The dural opening closure device is placed on the dural opening, and the gelatin sponge, catgut and nickel-titanium alloy in the tube are pushed out of the tube through the push rod. On the graduation line, first accurately push the gelatin sponge into the dural opening. After absorbing water, the gelatin sponge expands radially from the first structure to the second structure. At this time, the expanded gelatin sponge touches and covers the inner dural opening. On the surface, the circumference of the gelatin sponge is greater than the circumference of the dural opening. Then push the nickel-titanium alloy and catgut from the tube, observe the scale line or the distal end of the package assembly made of transparent material, and further confirm that the relevant parts are separated from the tube. Since Nitinol is a memory alloy material, the Nitinol alloy is restored from the contracted structure to the expanded structure without any external force intervention. The Nitinol in the expanded structure contacts and covers the outside of the hard film opening. On the surface, the circumference of the Nitinol alloy is greater than the circumference of the hard film opening. At the same time, under the action of the catgut, the outer edge of the dural opening is firmly clamped between the gelatin sponge and the nickel-titanium alloy, thereby closing the dural opening, and the closed dural opening has a waterproof and repairing effect.

Fig. 3 is a schematic diagram of the Nitinol alloy recovering from the contracted structure to the expanded structure. As shown in the figure, the nickel-titanium alloy presents a contraction structure in the package assembly. After the nickel-titanium alloy is separated from the package assembly, it gradually returns to the expanded structure under the shape memory of the memory metal material. The nickel-titanium alloy in the expanded structure contacts and Covering the outer surface of the hard film opening, the perimeter of the nickel-titanium alloy is greater than the perimeter of the hard film opening. The top view of the nickel-titanium alloy in the unfolded state is shown in FIG. 4, and the structure of the nickel-titanium alloy at this time is an umbrella structure.

Figure 5 is a schematic diagram of the connection between catgut and gelatin sponge. As shown in the figure, the number of catgut is two. The catgut passes through the bottom of the gelatin sponge and penetrates again to fix and support the gelatin sponge. Part of the catgut is placed on the outer surface of the bottom of the gelatin sponge. After the gelatin sponge, catgut and nickel-titanium alloy are separated from the package assembly, the gelatin sponge radially expands from the first structure to the second structure in the dura opening. The nickel-titanium alloy undergoes the shape memory of the memory metal material. The contracted structure is restored to the expanded structure. The gelatin sponge and the nickel-titanium alloy are connected by the catgut. Under the restriction of the catgut, the expanded gelatin sponge contacts and covers the inner surface of the dural opening. The circumference of the gelatin sponge is larger than the dura mater. The perimeter of the opening is in contact with and covers the outer surface of the hard film opening with Nitinol, and the perimeter of the Nitinol alloy is greater than the perimeter of the hard film opening. The outer edge of the dural opening is clamped between the gelatin sponge and Nitinol.

It should be pointed out that the thread structure in this embodiment is catgut, in other embodiments it can be catgut or polylactic acid suture or polyglycolide suture or polyglycolic acid PGA suture or polypara-2 Oxyhexanone sutures or silk threads or nylon sutures or polyester sutures or polypropylene sutures or any other material that can be used as a thread structure.

Example 2

6 is a schematic structural cross-sectional view of Embodiment 2 of the dural opening closure device, which includes an inner support assembly 1, an outer compression assembly 2, a connection assembly 3, a packaging assembly 4 and a push rod 6. The packaging component 4 includes a pipe 5 in which an inner supporting component 1, a connecting component 3 and an outer pressing component 2 are placed in sequence, and the inner supporting component 1 and the outer pressing component 2 are connected by the connecting component 3. Among them, the inner support component 1 is a composite material composed of a gelatin sponge 1-1 and a dural patch (1-2a and 1-2b). The two sides of the gelatin sponge 1-1 are arranged with dural patch 1-2a and 1 respectively. -2b. Since the hard film patch is not an swelling material, the gelatin sponge 1-1 is compressed into the first structure in advance, as shown in Figure 6, to ensure that the whole can be installed in the package assembly 4 and can be pushed into the hard film during operation. In the membrane opening, the circumference of the gelatin sponge 1-1 in the first structure state is smaller than the circumference of the dural opening. The external compression component 2 is a composite material composed of Nitinol 2-1 and the hard film patch 2-2. One side of the Nitinol 2-1 is in contact with the hard film patch 2-2, as shown in Figure 7. As shown, the nickel-titanium alloy 2-1 has an umbrella-shaped structure with a circular arc shape inside, and a threading hole is opened in the middle to connect with the connecting assembly 3. The Nitinol 2-1 is pre-compressed to a shrinkage structure, as shown in FIG. 6, to ensure that the whole can be installed in the package assembly 4. The connecting component 3 is a wire made of elastic material. The distal end of the package assembly 4 is made of transparent material. During operation, the push rod 6 is placed in the packaging assembly 4, and arranged at the proximal end of the dural opening closing device, and is in contact with the external pressing assembly 2 for connecting the external pressing assembly 2, the connecting assembly 3 and The inner support assembly 1 is pushed out from the packaging assembly 4. Preferably, the push rod 6 is marked with scale lines along the length direction.

Figure 8 is a diagram of the operation steps of the dural opening closure device. The dural opening closure device is placed on the dural opening, and the inner support assembly 1, the silk thread and the outer compression assembly 2 in the tube are pushed out of the tube through the push rod 6. With the help of the scale line on the push rod 6, the inner support assembly 1 is accurately pushed into the dural opening. After the gelatin sponge 1-1 absorbs water, it expands radially from the first structure to the second structure. At this time, the gelatin sponge 1- The circumference of 1 is greater than the circumference of the dural opening, the upper dural patch 1-2a is supported, and the circumference of the dural patch 1-2a is greater than the circumference of the dural opening, so that the dural patch 1-2a touches and covers the inner surface of the dural opening. Then push the outer compression assembly 2 and the wire out of the tube, observe the distal end of the package assembly made of transparent material, and further confirm that the relevant parts are separated from the tube. As Nitinol 2-1 is a memory alloy material, Nitinol 2-1 recovers from a contraction structure to an unfolded structure without any external force intervention when it is separated from the package assembly 4, and is hard bonded to Nitinol 2-1. The dura mater 2-2 contacts and covers the outer surface of the dura mater opening, and the perimeters of the nickel-titanium alloy 2-1 and the dura mater patch 2-2 are both greater than the perimeter of the dura mater opening. At the same time, under the action of the silk thread, the outer edge of the dural opening is firmly clamped between the inner support component 1 and the outer pressing component 2 to close the dural opening, and the closed dural opening has a waterproof repair function.

FIG. 9 is a schematic diagram of the external compression assembly 2 returning from the contracted structure to the expanded structure. As shown in the figure, the external compression component 2 is in a contracted structure inside the packaging component. After the external compression component 2 is separated from the packaging component, it gradually returns to the expanded structure under the shape memory of the memory metal material. 1. The attached dural patch 2-2 contacts and covers the outer surface of the dural opening. The perimeters of the Nitinol 2-1 and the dural patch 2-2 are both larger than the perimeter of the dural opening. The top view of the outer pressing assembly 2 in the expanded structure state is shown in FIG. 10, and the structure of the outer pressing assembly 2 at this time is an umbrella structure.

FIG. 10 is a schematic diagram of the connection between the wire and the inner support assembly 1. As shown in the figure, the number of silk threads is 2. The silk threads are threaded out from the bottom of the dural patch 1-2b and inserted again to fix and support the inner support component 1. Part of the silk threads are placed on the dural patch 1-2b The outer surface of the bottom. After the inner support assembly 1, the wire and the outer compression assembly 2 are separated from the package assembly, the gelatin sponge 1-1 expands radially from the first structure to the second structure in the hard film opening, and the nickel titanium alloy 2-1 is in the memory Under the action of the shape memory of the metal material, the contracted structure is restored to the expanded structure. The inner support assembly 1 and the outer compression assembly 2 are connected by a silk thread. Under the restriction of the silk thread, the upper dural patch 1-2a is expanded by the gelatin sponge Support, and the circumference of the dural patch 1-2a is greater than the circumference of the dural opening, so that the dural patch 1-2a contacts and covers the inner surface of the dural opening. The dura mater 2-2 attached to the Nitinol 2-1 is in contact with and covers the outer surface of the dura mater opening. The circumferences of the Nitinol 2-1 and dura mater 2-2 are both larger than the circumference of the dura mater opening. long. The outer edge of the dural opening is clamped between the inner support assembly 1 and the outer compression assembly 2. Preferably, the dural patch 1-2 and the gelatin sponge 1-1 can be bonded by a biological protein glue to increase the structural strength.

In this embodiment, the dural patch can be type I collagen material or pericardium material or polylactic acid material or expanded polytetrafluoroethylene or silk fibroin or medical polyester film or artificial synthetic repair material or any other Used as a material for dural patch. For example, the dural patch can be any one or a combination of the following materials:

1. Integra LifeSciences' DURAGEN dural repair material, DURAGEN is processed and produced from bovine Achilles tendon, which is considered to be the purest source of type I collagen commercially available;

2. Patent CN2418880Y mentioned a kind of absorbable composite layer structure material for dural defect repair, which is made of polylactic acid as raw material woven into polylactic acid fabric, and a layer containing glycerin and norfloxacin is coated on one side of the fabric A mixed solution with chitosan, an artificial dura mater that is cured into a film;

3. Baxter's PEG coated collagen gasket;

4. TachoSil hard film sealant from Takeda Austria GmbH;

5. Tianyifu's DuraMax product, the ingredient is bovine tendon type I collagen;

6. Guanhao's NormalGen product, the ingredient is pig-derived pericardium;

7. The Dura Scaffold product of Bairensi Company, the ingredient is bovine pericardium;

8. The Dura-Guard product of Synovis, the ingredient is bovine pericardium treated with glutaraldehyde;

9. Johnson & Johnson's Ethisorb product, the composition is artificial chemical synthetic material (Vicryl and PDS foil), similar to polyester sheet;

10. The SeamDura product of Johnson & Johnson, which is made of absorbable polymer synthetic material polyglycolic acid (PGA), copolymer of L-lactic acid and ε-caprolactone through processing, and is a three-layer sandwich composite structure , The middle is a polyglycolic acid non-woven fabric layer, and its two sides are copolymer films of L-lactic acid and ε-caprolactone;

11. BBraun’s Neuro-Patch product is made of synthetic polyester urethane;

12. Gore's Preclude product is made of expanded polytetrafluoroethylene.

The above are only preferred specific embodiments of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art can easily think of changes or changes within the technical scope disclosed by the present invention. All replacements shall be covered within the protection scope of the present invention. Therefore, the protection scope of the present invention should be subject to the protection scope of the claims.

Claims

A hard film opening closing device, which is characterized in that it comprises an inner support component, an outer compression component, a connection component, and a packaging component. The packaging component includes a pipe. The inner support component, the connection component and the outer compression component are sequentially placed in the pipe ；

The inner support component includes an expansion material, the inner support component radially expands from a first structure to a second structure under the action of the expansion material, the inner support component maintains the first structure in the packaging component, and the first structure The perimeter of the inner support component in one structure is smaller than the perimeter of the dural opening; when the inner support component separates from the packaging component and enters the dura opening, it radially expands to the second structure, and the inner support component in the second structure state The circumference of the supporting component is greater than the circumference of the dural opening, so that the inner supporting component contacts and covers the inner surface of the dural opening;

The external compression component includes a memory metal material, and the external compression component is restored from a contracted structure to an expanded structure under the shape memory of the memory metal material; the external compression component is in a contracted structure in the packaging component; The external compression component returns to the expanded structure after being separated from the packaging component. The circumference of the external compression component in the expanded structure state is greater than the circumference of the dural opening, so that the external compression component contacts and covers the dural opening. The outer surface;

The inner support component and the outer compression component are connected by the connection component, the connection component is a wire structure, and the connection component clamps the outer edge of the dura opening between the inner support component and the outer compression component between.
The dural opening closure device according to claim 1, further comprising a push rod, the push rod is placed in the packaging component and arranged at the proximal end of the dural opening closure device, and The contact of the outer pressing component is used to push the outer pressing component, the connecting component and the inner supporting component out of the packaging component.
The dural opening closure device according to claim 2, wherein the push rod is marked with a scale line along the length direction.
The dural opening closure device of claim 1, wherein the swelling material is gelatin sponge.
The dural opening closure device according to claim 1, wherein the inner support component is a composite material composed of a gelatin sponge and a dura patch, and the dura patch is arranged on both sides of the gelatin sponge, and the The dural patch on one side is in contact with the inner surface of the dural opening, and the perimeter of the dural patch is greater than the perimeter of the dural opening, so that the dural patch contacts and covers the inner surface of the dural opening .
The dural opening closure device according to claim 5, wherein the dural patch is made of type I collagen material, pericardium material, polylactic acid material, expanded polytetrafluoroethylene, silk fibroin, medical It is made of a combination of one or more materials in polyester film or artificial synthetic repair materials.
The dural opening closure device according to claim 5, wherein the dural patch and the gelatin sponge are pasted by a biological protein glue.
The dural opening closure device according to claim 1, wherein the outer compression component is an umbrella-shaped structure, the inside is arc-shaped, and a threading hole is provided in the middle to connect with the connecting component.
The dural opening closure device according to claim 1, wherein the memory metal material is Nitinol.
The dural opening closure device according to claim 1, wherein the external pressing component further comprises a dura patch, one side of the memory metal material is in contact with the dura patch, so The other side of the dural patch contacts and covers the outer surface of the dural opening, and the circumference of the dural patch is greater than the circumference of the dural opening.
The dural opening closure device according to claim 1, wherein the thread structure is made of elastic material.
The dural opening closure device according to claim 1, wherein the thread structure is catgut, polylactic acid suture, polyglycolide suture, polyglycolic acid PGA suture, polypara 2 One or a combination of oxanone sutures, silk threads, nylon sutures, polyester sutures or polypropylene sutures.
The dural opening closure device according to claim 1, wherein the inner supporting component, the outer pressing component and the connecting component are all made of biocompatible materials.
The dural opening closure device according to claim 1, wherein the distal end of the packaging component is made of a transparent material.