WO2021030882A1 - Improvement applied to dental implant - Google Patents
Improvement applied to dental implant Download PDFInfo
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- WO2021030882A1 WO2021030882A1 PCT/BR2019/050343 BR2019050343W WO2021030882A1 WO 2021030882 A1 WO2021030882 A1 WO 2021030882A1 BR 2019050343 W BR2019050343 W BR 2019050343W WO 2021030882 A1 WO2021030882 A1 WO 2021030882A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
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- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C22/00—Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals
- C23C22/05—Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions
- C23C22/06—Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions using aqueous acidic solutions with pH less than 6
Definitions
- This utility model patent application refers to an improvement introduced in dental implant, whose function consists of titanium dioxide dental implant illuminated with UV (ultraviolet) light on its surface.
- the referred system stands out, fundamentally, for the most practical, simple and functional way to accelerate the osseointegration of dental implants, being the same endowed with unique, exclusive and innovative functional aspects, which will be described below.
- Photocatalysis occurs with UV or solar light in contact with titanium dioxide which results in a chemical oxidation reaction.
- Titanium dioxide has a strong affinity for water, a feature known as super-wettability.
- the water present in the atmosphere binds with oxygen from titanium dioxide, forming the hydroxyl group (OH). Hydroxyl degrades organic matter and eliminates microorganisms and bacteria.
- the surface wettability of dental implants presents a great advantage for osseointegration and improvements in the acceleration of bone anchorage during the beginning of the healing process.
- Modifications of surfaces in dental implants improve the wettability and adsorption of extracellular proteins. Anodized titanium dioxide when irradiated with UV ultraviolet light produces super-wettability.
- the anatase phase of titanium dioxide is a material that contributes to osseointegration improvements for certain applications, in other words, it acts as a photocatalyst that is a semiconductor that provides strong oxidation on the surface, on the irradiation of ultraviolet light (UV) ), results in the decomposition of various organic compounds and provides an extreme cleaning of the surface.
- ultraviolet (UV) radiation can create a space on the surface between titanium and oxygen atoms. This effect makes a union with the H2O molecules around it, forming OH with dominance over the hydrophilic layers.
- titanium The physical and chemical characteristics of titanium are relevant and suitable for biomedical applications. In particular, most of these intrinsic properties such as biocompatibility, low specific weight, high strength, low modulus of elasticity and resistance to corrosion, are favorable for the production of dental implants.
- the treatment promotes cell adhesion, growth and differentiation for an important process healing and increased bone formation which accelerates the process of osseointegration of dental implants.
- an electrochemical process occurs that results in a layer of titanium dioxide with the formation of nanotubes (pores). This thin layer of titanium dioxide that forms on the surface of the dental implant reduces the release of metal ions and increases corrosion resistance.
- Dental implants are submerged in an acidic solution and positive and negative charges (voltage) are applied that create an electric field resulting in the formation of an oxide film on the surface.
- the system in question, presented through this report, is composed of: titanium implant; transformed into layers on its surface by electrochemical methods, transforming titanium into titanium dioxide and being used by UV light.
- FIGURE 1 illustrates the representative image of surface tension and contact angle.
- FIGURE 2 illustrates the analysis of cell adhesion and proliferation, photocatalysis through UV illumination provides better cell adhesion and also greater proliferation.
- FIGURE 3 illustrates the micrograph analysis of the implants after two weeks.
- the letter C indicates the cut in the bone region and NB the arrowheads indicate the new bone formation.
- FIGURE 4 illustrates the analysis of the contact angle before and after illumination, with TiUnite with illumination and cp.Ti without illumination.
- FIGURE 5 illustrates the contact angle of DTiU (without illumination) and DmodTiU (with illumination) titanium discs, the behavior of anodized implants to improve osseintegration through the wetting induced by UV illumination in the early stages of healing.
- Anodized commercial discs and implants called DTiU (standard - without lighting) and DmodTiU (test - with lighting) were used and the contact angle result was 36.6 ° and 4.4 ° respectively.
- FIGURE 6 illustrates the micrograph of TiU and modTiU implants, being A (after two weeks); being B (after six weeks of healing); and being C (detail of the micrograph showing the section of the new bone formation in contact with the modTiU implant through the medullary region).
- FIGURE 7 illustrates bone-implant contact for TiU and changed after 2 and 6 weeks of healing.
- FIGURE 8 illustrates the graph with contact angle results for control sample (anodized) and UV-C sample 24h.
- FIGURE 10 illustrates the results of contact angle by surface treatment.
- BIC bone formation
- implants were inserted in tibiae of rabbits and after two weeks the results of BMC were analyzed and in implants with treatments and UV illumination (I + UV) the result was 28.2%, whereas implants treated with titanium, but without illumination (I-UV) presented a BMC value of 17.97%, that is, the implant treated with illumination showed a higher value than the implant without illumination, in which it concludes that titanium dioxide in the anatase phase activated by photocatalysis (UV light) provides significant improvements in bone formation promoting better osseointegration.
- I + UV implants treated with titanium, but without illumination
- UV light photocatalysis
- Titanium and its alloys have been widely used in the field of dentistry in dental implants due to their properties.
- the surface of the dental implant is of fundamental importance for the successful acceleration and osseintegration of the implant.
- the anatase phase is a crystalline phase of titanium dioxide and photocatalysis is a property that is activated by ultraviolet light on titanium dioxide surfaces.
- the wettability is measured by the contact angle and the smaller the contact angle, the greater the wettability, consequently speeding up the healing process.
- the anatase phase of titanium dioxide has photocatalytic activity under ultraviolet light (UVA). It is also known that photocatalysis breaks down various organic materials under UVA lighting. This effect of photo decomposition of organic components eliminates bacteria.
- UVA ultraviolet light
- the referred system represents a solution with regard to dental implants using UV light to accelerate osseointegration, the light creates crystalline layers that accelerate even more in healing.
- 37 For the analysis of bone formation, the average BMC value in two weeks of healing was 30.1% for TiU and 50.3% modTiU, that is, implant without UV illumination and with UV illumination, respectively. After 6 weeks, analyzes were also performed and the results were 37.1% and 47.6% for TiU and modTiu, respectively. It is verified that in both cases the implants treated and with UV light presented higher and significant values for bone formation, mainly in the first two weeks.
- Blasting occurs by the inclusion of particles of titanium dioxide (T1O2) on the surface of the dental implant creating a change in roughness by abrasion.
- This treatment can be followed by an acid attack using a hydrochloric / sulfuric acid solution (HCL / H2SO4).
- Titanium implants referring to the control group have smooth surfaces, while treated implants have rough surfaces, these characteristics are very important for the increase of bone formation and cell growth.
- UV irradiation contributes to promote osseointegration and decontamination of dental implants, contributing to the success of implantation and healing.
- the super-wetting with light on titanium dioxide is an effect with unique characteristics, its properties of decomposition power of organic matter and still releasing properties such as hydroxyl and positive ions promotes improvements for human health leaving free of ions corrosive negatives that cause perimplantitis and may be a new surface treatment to improve the quality of life of patients using prostheses.
- the process presented in the patent application BR 10 2016 017438 4 refers to an electronic circuit excited by high frequency electromagnetic waves (RF), as well as its support structure, positioning and electrical connections to a dental implant for generation of electrical current on the implant surface promoting a reduction in the osseointegration time of the implant to the patient's bone;
- the proposed system includes a prosthetic component, a metallic implant, a support, upper electrical conductors, an electronic device, a lower electrical conductor, a support piston, flexible positioning element and conductive terminal for electrical contact;
- the external energy transmitter transmits, via electromagnetic radio frequency (RF) waves, an amount of electrical energy into the prosthetic component.
- RF radio frequency
Abstract
The present utility model patent application is essentially characterized by an improvement made to a dental implant, the function of which is a dental implant made of titanium dioxide illuminated with UV light on the surface thereof. It comprises a titanium implant, transformed into layers on the surface thereof using electrochemical methods, transforming the titanium into titanium dioxide and being used by the UV light. The photocatalysis (combination of titanium dioxide with sunlight or artificial UV light) occurs with UV light or sunlight in contact with titanium dioxide, which results in a chemical oxidizing reaction. The titanium dioxide anodized when irradiated with UV light produces super-wettability. The contact angle was measured and the result for the TiUnite implants with UV illumination drastically reduced the contact angle from 44° to 11°, and this reduction is related to the photocatalytic properties and after 4 weeks' healing, an assessment was made of the bone formation in which the TiUnite implants with UV light and Ti without UV light gave the results 47.3% and 41.3% respectively for bone mineral content (BMC). For analysis of the bone formation, implants were inserted into rabbit tibias and after two weeks the BMC results were analyzed and in the implants with treatments and UV illumination (I+UV) the result was 28.2%, while the implants treated with titanium dioxide but without illumination (I-UV) gave a BMC value of 17.97%, i.e. the implant treated with illumination gave a value higher than the implant without illumination, from which it is concluded that the titanium dioxide in the anatase phase activated by photocatalysis (UV light) provides significant improvements in bone formation promoting better osseointegration. UV irradiation helps to promote osseointegration and decontamination of the dental implants, helping to ensure successful implantation and healing.
Description
APERFEIÇOAMENTO INTRODUZIDO EM IMPLANTE DENTÁRIO IMPROVEMENT INTRODUCED IN DENTAL IMPLANT
CAMPO DE APLICAÇÃO: APPLICATION FIELD:
1. O referido sistema, cuja proteção será reivindicada neste relatório, foi desenvolvido com o intuito de suprir deficiências, amenizar dificuldades e solucionar problemas até então encontrados pelos usuários do setor, mais precisamente, setor da odontologia. INTRODUÇÃO: 1. The referred system, whose protection will be claimed in this report, was developed in order to supply deficiencies, alleviate difficulties and solve problems hitherto encountered by users in the sector, more precisely, the dentistry sector. INTRODUCTION:
2. Refere-se o presente pedido de patente de Modelo de Utilidade, a um aperfeiçoamento introduzido em implante dentário, cuja função consiste em implante dentário de dióxido titânio iluminado com luz UV (ultravioleta) na superfície do mesmo. 2. This utility model patent application refers to an improvement introduced in dental implant, whose function consists of titanium dioxide dental implant illuminated with UV (ultraviolet) light on its surface.
3. O referido sistema destaca-se, fundamentalmente, pela forma mais prática, simples e funcional na aceleração da osseointegração de implantes dentários, sendo o mesmo dotado de aspectos funcionais únicos, exclusivos e inovadores, que serão descritos a seguir. 3. The referred system stands out, fundamentally, for the most practical, simple and functional way to accelerate the osseointegration of dental implants, being the same endowed with unique, exclusive and innovative functional aspects, which will be described below.
4. A fotocátalise (combinação de dióxido de titânio com a luz solar ou luz artificial UV) ocorre com a luz UV ou solar em contato com dióxido de titânio que resulta em uma reação química de oxidação. O dióxido de titânio apresenta forte afinidade por água, uma característica conhecida como super-molhabilidade. A água presente na atmosfera se liga com oxigénio proveniente do dióxido de titânio, formando o grupo hidroxila (OH). A hidroxila realiza a degradação da matéria orgânica e elimina ainda microorganismos e bactérias. 4. Photocatalysis (combination of titanium dioxide with sunlight or artificial UV light) occurs with UV or solar light in contact with titanium dioxide which results in a chemical oxidation reaction. Titanium dioxide has a strong affinity for water, a feature known as super-wettability. The water present in the atmosphere binds with oxygen from titanium dioxide, forming the hydroxyl group (OH). Hydroxyl degrades organic matter and eliminates microorganisms and bacteria.
5. Propriedades como a super-molhabilidade e fotocatálise relacionadas ao uso do dióxido de titânio tem contribuído significantemente para aceleração do processo de osseointegração em implantes. 5. Properties such as super-wettability and photocatalysis related to the use of titanium dioxide have contributed significantly to accelerating the process of osseointegration in implants.
6. O uso do dióxido de titânio aplicado em implantes dentários promove melhorias de osseointegração sem apresentar toxidade aos humanos. É possível, ainda, obter-se uma modificação da superfície por meio da fase cristalina anatase. 6. The use of titanium dioxide applied in dental implants promotes osseointegration improvements without presenting toxicity to humans. It is also possible to obtain a modification of the surface by means of the crystalline anatase phase.
7. A molhabilidade da superfície de implantes dentários apresenta uma grande vantagem para a osseointegração e melhorias na aceleração de ancoragem óssea durante o início do processo de cicatrização.
8. Modificações de superfícies em implante dentário melhoram a molhabilidade e adsorção de proteínas extracelulares. O dióxido de titânio anodizado quando irradiado com luz ultravioleta UV produz uma super-molhabilidade. 7. The surface wettability of dental implants presents a great advantage for osseointegration and improvements in the acceleration of bone anchorage during the beginning of the healing process. 8. Modifications of surfaces in dental implants improve the wettability and adsorption of extracellular proteins. Anodized titanium dioxide when irradiated with UV ultraviolet light produces super-wettability.
9. A fase anatase do dióxido de titânio é um material que contribui para melhorias de osseointegração para certas aplicações, em outras palavras, atua como um fotocatalisador que é um semicondutor que proporciona uma forte oxidação na superfície, sobre a irradiação da luz ultravioleta (UV), resulta na decomposição de vários compostos orgânicos e proporciona uma extrema limpeza da superfície. Além disso a radiação ultravioleta (UV) pode criar um espaço na superfície entre o titânio e átomos de oxigénio. Esse efeito realiza uma união com as moléculas de H2O para seu redor, formando-OH com domínio sobre as camadas hidrofílicas. 9. The anatase phase of titanium dioxide is a material that contributes to osseointegration improvements for certain applications, in other words, it acts as a photocatalyst that is a semiconductor that provides strong oxidation on the surface, on the irradiation of ultraviolet light (UV) ), results in the decomposition of various organic compounds and provides an extreme cleaning of the surface. In addition, ultraviolet (UV) radiation can create a space on the surface between titanium and oxygen atoms. This effect makes a union with the H2O molecules around it, forming OH with dominance over the hydrophilic layers.
10. Estudos indicam que a molhabilidade da superfície de implantes dentários apresenta uma grande vantagem para a osseointegração e melhorias na aceleração de ancoragem óssea durante o início do processo de cicatrização. 10. Studies indicate that the surface wettability of dental implants presents a great advantage for osseointegration and improvements in bone anchorage acceleration during the beginning of the healing process.
11. As características físicas e químicas do titânio são relevantes e adequadas para aplicações biomédicas. Em particular a maioria dessas propriedades intrínsecas tais como biocompatibilidade, baixo peso especifico, alta resistência, baixo módulo de elasticidade e resistência à corrosão, são favoráveis para a produção de implantes dentários. 11. The physical and chemical characteristics of titanium are relevant and suitable for biomedical applications. In particular, most of these intrinsic properties such as biocompatibility, low specific weight, high strength, low modulus of elasticity and resistance to corrosion, are favorable for the production of dental implants.
12. Quando a superfície do implante dentário é coberta com a fase anatase do dióxido de titânio e é foto-ativado pela irradiação ultravioleta (UV) produz uma super-molhabilidade, o tratamento promove a adesão, crescimento e diferenciação de células para um importante processo de cicatrização e aumento da formação óssea o qual acelera o processo de osseointegração dos implantes dentários. 12. When the surface of the dental implant is covered with the anatase phase of titanium dioxide and is photo-activated by ultraviolet (UV) irradiation produces super-wettability, the treatment promotes cell adhesion, growth and differentiation for an important process healing and increased bone formation which accelerates the process of osseointegration of dental implants.
13. Na oxidação anódica, também chamada de anodização eletroquímica ou simplesmente anodização, ocorre um processo eletroquímico que resulta em uma camada de dióxido de titânio com formação de nanotubos (poros). Essa fina camada de dióxido de titânio que se forma na superfície do implante dentário reduz a liberação de íons de metais e aumenta a resistência à corrosão. Os implantes dentários são submersos em uma solução ácida e são aplicadas cargas (voltagem) positiva e negativa que criam um campo elétrico resultando na formação de filme óxido na superfície.
CARACTERÍSTIC AS : 13. In anodic oxidation, also called electrochemical anodization or simply anodization, an electrochemical process occurs that results in a layer of titanium dioxide with the formation of nanotubes (pores). This thin layer of titanium dioxide that forms on the surface of the dental implant reduces the release of metal ions and increases corrosion resistance. Dental implants are submerged in an acidic solution and positive and negative charges (voltage) are applied that create an electric field resulting in the formation of an oxide film on the surface. CHARACTERISTICS :
14. O sistema em questão, apresentado por meio deste relatório, é composto por: implante de titânio; transformado em camadas na sua superfície através de métodos de eletroquímico, transformando o titânio em dióxido de titânio e sendo utilizado pela luz UV. FIGURAS: 14. The system in question, presented through this report, is composed of: titanium implant; transformed into layers on its surface by electrochemical methods, transforming titanium into titanium dioxide and being used by UV light. FIGURES:
15. Inicialmente, para melhor demonstrar tais características, e visando uma compreensão clara e objetiva acerca das disposições aplicadas no presente modelo de utilidade, serão apresentados desenhos em caráter demonstrativo, fazendo referências ao relatório que seguem em anexo. 15. Initially, in order to better demonstrate these characteristics, and aiming at a clear and objective understanding of the provisions applied in the present utility model, demonstrative drawings will be presented, making references to the report that are attached.
16. A FIGURA 1 ilustra a imagem representativa de tensão superficial e ângulo de contato. 16. FIGURE 1 illustrates the representative image of surface tension and contact angle.
17. A FIGURA 2 ilustra a análise de adesão e proliferação de células, a fotocatálise por meio da iluminação UV proporciona melhor adesão de células e também maior proliferação. 17. FIGURE 2 illustrates the analysis of cell adhesion and proliferation, photocatalysis through UV illumination provides better cell adhesion and also greater proliferation.
18. A FIGURA 3 ilustra a análise de micrografia dos implantes após duas semanas. É apresentado a resposta de formação óssea para os implantes sem iluminação I-UV (figura a) e com iluminação I=UV (figura b). A letra C indica o corte na região óssea e NB as cabeças de setas indicam a nova formação óssea. 18. FIGURE 3 illustrates the micrograph analysis of the implants after two weeks. The bone formation response for implants without I-UV illumination (figure a) and with I = UV illumination (figure b) is presented. The letter C indicates the cut in the bone region and NB the arrowheads indicate the new bone formation.
19. A FIGURA 4 ilustra a análise do ângulo de contato antes e após iluminação, sendo TiUnite com iluminação e cp.Ti sem iluminação. 19. FIGURE 4 illustrates the analysis of the contact angle before and after illumination, with TiUnite with illumination and cp.Ti without illumination.
20. A FIGURA 5 ilustra o ângulo de contato de discos de titânio DTiU (sem iluminação) e DmodTiU (com iluminação), o comportamento de implantes anodizados para melhorias de osseintegração por meio da molhabilidade induzida por iluminação UV nos estágios iniciais de cicatrização. Foram utilizados discos e implantes comerciais anodizados chamados DTiU (padrão - sem iluminação) e DmodTiU (teste - com iluminação) e o resultado de ângulo de contato foi de 36.6° e 4.4° respectivamente. 20. FIGURE 5 illustrates the contact angle of DTiU (without illumination) and DmodTiU (with illumination) titanium discs, the behavior of anodized implants to improve osseintegration through the wetting induced by UV illumination in the early stages of healing. Anodized commercial discs and implants called DTiU (standard - without lighting) and DmodTiU (test - with lighting) were used and the contact angle result was 36.6 ° and 4.4 ° respectively.
21. A FIGURA 6 ilustra a micrografia de implantes TiU e modTiU, sendo A (depois de duas semanas); sendo B (depois de seis semanas de cicatrização); e sendo C (detalhe da micrografia mostrando a seção da nova formação óssea em contato com o modTiU implante através da região medular).
22. A FIGURA 7 ilustra o contato osso - implante para o TiU e modTiu após 2 e 6 semanas de cicatrização. 21. FIGURE 6 illustrates the micrograph of TiU and modTiU implants, being A (after two weeks); being B (after six weeks of healing); and being C (detail of the micrograph showing the section of the new bone formation in contact with the modTiU implant through the medullary region). 22. FIGURE 7 illustrates bone-implant contact for TiU and changed after 2 and 6 weeks of healing.
23. A FIGURA 8 ilustra o gráfico com resultados de ângulo de contato para amostra controle (anodizado) e amostra UV-C 24h. 23. FIGURE 8 illustrates the graph with contact angle results for control sample (anodized) and UV-C sample 24h.
24. A FIGURA 9 ilustra o comportamento da redução do ângulo de contato, sendo: CG = implante padrão e EG = implante tratado superfície SLA. 24. FIGURE 9 illustrates the behavior of the reduction of the contact angle, being: CG = standard implant and EG = implant treated with SLA surface.
25. A FIGURA 10 ilustra os resultados de ângulo de contato por tratamento de superfície. 25. FIGURE 10 illustrates the results of contact angle by surface treatment.
26. Cabe esclarecer que as imagens acima relacionadas ilustram o sistema em caráter demonstrativo e não restritivo, cuja concepção poderá variar quanto às suas medidas, matéria-prima, dimensões, etc, sem fugir logicamente, do escopo principal cuja proteção é reivindicada. 26. It should be clarified that the images listed above illustrate the system in a demonstrative and non-restrictive manner, the design of which may vary in terms of its measures, raw material, dimensions, etc., without logically departing from the main scope whose protection is claimed.
FUNCIONALIDADE: FUNCTIONALITY:
27. Inicialmente o referido sistema, descrito por meio deste relatório, será utilizado no setor da odontologia. 27. Initially, this system, described in this report, will be used in the dentistry sector.
28. A análise de formação óssea (BIC) pode-se constatar que a maior diferença e aumento significativo de BIC é encontrado nas duas primeiras semanas de cicatrização. Após 4 semanas não existe alteração significativa, o que leva a conclusão que a completa- molhabilidade é ativada pela fotocatálise, ou seja, superfície de dióxido de titânio com iluminação UV acelera o processo inicial de osseintegração, contribuindo para o sucesso do tratamento e permanência dos implantes inseridos. 28. Analysis of bone formation (BIC) shows that the biggest difference and significant increase in BIC is found in the first two weeks of healing. After 4 weeks there is no significant change, which leads to the conclusion that complete wettability is activated by photocatalysis, that is, a titanium dioxide surface with UV illumination accelerates the initial osseintegration process, contributing to the success of the treatment and permanence of the inserted implants.
29. A completa-molhabilidade foi comprovada pela medição do ângulo de contato, no qual os implantes tratados e com iluminação UV apresentaram ângulo de contato menor.29. Complete wettability was proven by measuring the contact angle, in which the treated implants and with UV illumination showed a smaller contact angle.
30. A decomposição de materiais orgânicos contribuí para eliminação e redução de bactérias que contribuem para a doença de peri-implantities. Realizou-se medida do ângulo de contato e o resultado para os implantes TiUnite com iluminação UV reduziram drasticamente o ângulo de contato de 44° para 11°, e essa redução é relacionada as propriedades fotocatalíticas. Após 4 semanas de cicatrização avaliou-se a formação óssea na qual os implantes TiUnite com luz UV e Ti sem luz UV apresentaram os resultados de 47,3% e 41,3%, respectivamente para BMC (bone mineral content).
31. Para análise da formação óssea foram inseridos implantes em tíbias de coelhos e após duas semanas analisados os resultados de BMC e nos implantes com tratamentos e iluminação UV (I+UV) o resultado foi de 28.2%, já os implantes tratados com dióxido de titânio, mas sem iluminação (I-UV) apresentou valor de BMC de 17,97%, ou seja, o implante tratado com iluminação apresentou valor superior ao implante sem iluminação, na qual conclui que o dióxido de titânio na fase anatase ativado pela fotocatálise (luz UV) proporciona melhorias significativas para formação óssea promovendo melhor osseointegração. 30. The decomposition of organic materials contributes to the elimination and reduction of bacteria that contribute to the disease of peri-implantities. The contact angle was measured and the result for TiUnite implants with UV illumination dramatically reduced the contact angle from 44 ° to 11 °, and this reduction is related to the photocatalytic properties. After 4 weeks of healing, bone formation was evaluated in which TiUnite implants with UV light and Ti without UV light showed the results of 47.3% and 41.3%, respectively for BMC (bone mineral content). 31. For bone formation analysis, implants were inserted in tibiae of rabbits and after two weeks the results of BMC were analyzed and in implants with treatments and UV illumination (I + UV) the result was 28.2%, whereas implants treated with titanium, but without illumination (I-UV) presented a BMC value of 17.97%, that is, the implant treated with illumination showed a higher value than the implant without illumination, in which it concludes that titanium dioxide in the anatase phase activated by photocatalysis (UV light) provides significant improvements in bone formation promoting better osseointegration.
32. Titânio e suas ligas tem sido largamente utilizado na área de odontologia em implantes dentários devido as suas propriedades. A superfície do implante dentário apresenta fundamental importância para o sucesso de aceleração e osseintegração do implante. 32. Titanium and its alloys have been widely used in the field of dentistry in dental implants due to their properties. The surface of the dental implant is of fundamental importance for the successful acceleration and osseintegration of the implant.
33. No decorrer dos últimos anos reconheceu-se os benefícios proporcionados pelo dióxido de titânio na superfície dos implantes dentários que aceleram o processo de osseointegração de implantes dentários nos estágios iniciais da cicatrização e contribui para uma melhor qualidade de vida para os pacientes. Propriedades como a super-molhabilidade e a fotocatálise estão diretamente relacionadas a utilização de dióxido de titânio na fase anatase e potencializam as melhorias de osseintegração, promovendo uma aceleração na cicatrização e osseointegração de pacientes que realizam implantes dentário. 33. Over the past few years, the benefits of titanium dioxide on the surface of dental implants have been recognized to accelerate the process of osseointegration of dental implants in the early stages of healing and contribute to a better quality of life for patients. Properties such as super-wettability and photocatalysis are directly related to the use of titanium dioxide in the anatase phase and enhance osseintegration improvements, promoting accelerated healing and osseointegration in patients undergoing dental implants.
34. A fase anatase é uma fase cristalina do dióxido de titânio e a fotocatálise é uma propriedade que é ativada pela luz ultravioleta em superfícies de dióxido de titânio. A molhabilidade é medida pelo ângulo de contato sendo que quanto menor o ângulo de contato maior será a molhabilidade, consequentemente acelera o processo de cicatrização. 34. The anatase phase is a crystalline phase of titanium dioxide and photocatalysis is a property that is activated by ultraviolet light on titanium dioxide surfaces. The wettability is measured by the contact angle and the smaller the contact angle, the greater the wettability, consequently speeding up the healing process.
35. A fase anatase do dióxido de titânio apresenta atividade fotocatalítica sob luz ultravioleta (UVA). Sabe-se ainda que a fotocatálise decompõe vários materiais orgânicos sob a iluminação UVA. Esse efeito de foto decomposição de componentes orgânicos eliminam bactérias. 35. The anatase phase of titanium dioxide has photocatalytic activity under ultraviolet light (UVA). It is also known that photocatalysis breaks down various organic materials under UVA lighting. This effect of photo decomposition of organic components eliminates bacteria.
INOVAÇÃO: INNOVATION:
36. Em termos gerais, o referido sistema representa uma solução no que diz respeito a implantes dentário utilizando luz UV para acelerar a osseointegração, a luz cria camadas cristalinas que aceleram ainda mais na cicatrização.
37. Para a análise de formação óssea o valor médio de BMC em duas semanas de cicatrização foi de 30.1% para o TiU e 50.3% modTiU, ou seja, implante sem iluminação UV e com iluminação UV, respectivamente. Após 6 semanas também foram realizadas análises e os resultados foram 37.1% e 47.6% para TiU e modTiu, respectivamente. Verifica- se que em ambos os casos os implantes tratados e com luz UV apresentaram valores superiores e significativos para formação óssea, principalmente nas duas primeiras semanas. 36. In general terms, the referred system represents a solution with regard to dental implants using UV light to accelerate osseointegration, the light creates crystalline layers that accelerate even more in healing. 37. For the analysis of bone formation, the average BMC value in two weeks of healing was 30.1% for TiU and 50.3% modTiU, that is, implant without UV illumination and with UV illumination, respectively. After 6 weeks, analyzes were also performed and the results were 37.1% and 47.6% for TiU and modTiu, respectively. It is verified that in both cases the implants treated and with UV light presented higher and significant values for bone formation, mainly in the first two weeks.
38. Trata-se de um sistema único, exclusivo e inovador, sendo altamente confiável e recomendável para uso em seu momento de implantação dentária, e certamente será um grande diferencial para o setor à qual se destina. 38. It is a unique, exclusive and innovative system, being highly reliable and recommended for use at the time of dental implantation, and it will certainly be a great differential for the sector to which it is intended.
39. Não existem diferenças significativas na análise qualitativa e quantitativa na formação óssea nos grupos com iluminação UV e sem iluminação UV. No entanto na análise genética sugeriu-se que para o grupo com iluminação UV na análise osteogênica houve um aumento significativo em termos de remodelação celular. Na análise genética de células com iluminação UV respondem positivamente para remodelação ativa e respostas aos processos inflamatórios. Mas acredita-se que realmente o efeito fotocatalítico para ativar a superfície do implante e resultar em osseintegração ocorre somente nos estágios iniciais de processo de cicatrização. 39. There are no significant differences in the qualitative and quantitative analysis of bone formation in groups with UV lighting and without UV lighting. However, in the genetic analysis it was suggested that for the group with UV illumination in the osteogenic analysis there was a significant increase in terms of cell remodeling. In the genetic analysis of cells with UV illumination they respond positively to active remodeling and responses to inflammatory processes. But it is believed that the photocatalytic effect to activate the implant surface and result in osseintegration occurs only in the initial stages of the healing process.
40. Na análise dos resultados de rugosidade de superfície (Ra) os valores foram 0.159 e 0.699 para os discos padrões e implante SLA, respectivamente. Verifica-se a alteração de superfície por tratamento de jateamento seguido por ataque ácido proporciona uma superfície mais rugosa. 40. In the analysis of the results of surface roughness (Ra) the values were 0.159 and 0.699 for standard discs and SLA implant, respectively. The alteration of the surface is verified by blasting treatment followed by acid attack provides a more rough surface.
41. O jateamento ocorre pela inclusão de partículas de dióxido de titânio (T1O2) na superfície do implante dentário criando uma alteração de rugosidade por abrasão. Esse tratamento pode ser seguido de ataque ácido utilizando uma solução de ácido clorídrico/sulfúrico (HCL/H2SO4). 41. Blasting occurs by the inclusion of particles of titanium dioxide (T1O2) on the surface of the dental implant creating a change in roughness by abrasion. This treatment can be followed by an acid attack using a hydrochloric / sulfuric acid solution (HCL / H2SO4).
42. Os resultados de ângulo de contato para as amostras tratadas com luz UV indicam maior molhabilidade do implante dentário. 42. The results of contact angle for samples treated with UV light indicate greater wettability of the dental implant.
43. Os resultados de ângulo de contato e formação óssea indicam que a irradiação UV contribui para promover a aceleração da cicatrização da osseointegração.
44. Os implantes de titânio referente ao grupo controle apresentam superfícies lisas, enquanto que os implantes tratados, apresentam superfícies rugosas, essas características são muito importantes para o aumento da formação óssea e crescimento celular. 43. The results of contact angle and bone formation indicate that UV irradiation contributes to promote the acceleration of osseointegration healing. 44. Titanium implants referring to the control group have smooth surfaces, while treated implants have rough surfaces, these characteristics are very important for the increase of bone formation and cell growth.
45. A aceleração da cicatrização e melhoria na formação óssea para osseointegração dos implantes dentários foram estudados por meio dos resultados de ângulo de contato, rugosidade e formação óssea. 45. The acceleration of healing and improvement in bone formation for osseointegration of dental implants were studied through the results of contact angle, roughness and bone formation.
46. A irradiação UV contribui para promover a osseointegração e descontaminação dos implantes dentários contribuído para o sucesso de implantação e cicatrização. 46. UV irradiation contributes to promote osseointegration and decontamination of dental implants, contributing to the success of implantation and healing.
47. A super-molhabilidade com a luz sobre o dióxido de titânio é um efeito com características únicas, suas propriedades de poder de decomposição de matéria orgânica e ainda liberando propriedades como a hidroxila e íons positivos promove melhorias para a saúde humana deixando livre de íons negativos corrosivos que causam perimplantites podendo ser um novo tratamento de superfície para melhorar a qualidade de vida de pacientes que fazem uso de próteses. 47. The super-wetting with light on titanium dioxide is an effect with unique characteristics, its properties of decomposition power of organic matter and still releasing properties such as hydroxyl and positive ions promotes improvements for human health leaving free of ions corrosive negatives that cause perimplantitis and may be a new surface treatment to improve the quality of life of patients using prostheses.
48. A combinação da fase anatase do dióxido de titânio adquiridos por todos os métodos expostos somados a irradiação por luz UV demonstraram melhorias na osseointegração. Sendo que a fotocátalise é uma propriedade que contribuiu para os resultados nos estudos que utilizaram a luz UV nos testes. 48. The combination of the titanium dioxide anatase phase acquired by all exposed methods plus UV radiation demonstrated improvements in osseointegration. Photocatalysis is a property that contributed to the results in studies that used UV light in the tests.
DESCRIÇÃO DO ESTADO DA TÉCNICA: DESCRIPTION OF THE STATE OF THE TECHNIQUE:
49. Durante o desenvolvimento do referido sistema, foram realizadas inúmeras pesquisas para identificar a existência de eventuais anterioridades ou sistemas afins. Tais levantamentos, contudo, não apontaram a existência de nenhum outro sistema com as mesmas características técnicas preponderantes ou funcionais. 49. During the development of this system, numerous researches were carried out to identify the existence of possible priorities or similar systems. Such surveys, however, did not indicate the existence of any other system with the same predominant or functional technical characteristics.
50. O processo apresentado no pedido de registro de patente BR 10 2016 017438 4, se refere a um circuito eletrónico excitado por ondas eletromagnéticas (RF) de alta frequência, bem como sua estrutura de sustentação, posicionamento e conexões elétricas a um implante dentário para geração de corrente elétrica na superfície do implante promovendo a redução no tempo de osseointegração do implante ao osso do paciente; o sistema proposto prevê um componente protético, um implante metálico, um suporte, condutores elétricos superiores, um dispositivo eletrónico, um condutor elétrico inferior, um êmbolo de sustentação,
elemento flexível de posicionamento e borne condutor para contato elétrico; o transmissor externo de energia transmite, via ondas eletromagnéticas de radiofrequência (RF), uma quantidade de energia elétrica para o interior do componente protético. 50. The process presented in the patent application BR 10 2016 017438 4, refers to an electronic circuit excited by high frequency electromagnetic waves (RF), as well as its support structure, positioning and electrical connections to a dental implant for generation of electrical current on the implant surface promoting a reduction in the osseointegration time of the implant to the patient's bone; the proposed system includes a prosthetic component, a metallic implant, a support, upper electrical conductors, an electronic device, a lower electrical conductor, a support piston, flexible positioning element and conductive terminal for electrical contact; the external energy transmitter transmits, via electromagnetic radio frequency (RF) waves, an amount of electrical energy into the prosthetic component.
51. O processo apresentado no parágrafo acima, se diz respeito a um sistema de implante dentário, contudo, o mesmo não utiliza a iluminação UV que acelera a osseointegração, o dióxido de titânio tem propriedades que atraem o sangue hidroficilidade, super- molhabilidade e com a luz UV ele acelera ainda mais a cicatrização. 51. The process presented in the paragraph above, concerns a dental implant system, however, it does not use UV lighting that accelerates osseointegration, titanium dioxide has properties that attract blood hydrophilicity, super-wetting and with UV light accelerates healing even more.
52. Diante dessa necessidade e oportunidade comercial, criou-se o referido sistema, mais precisamente um aperfeiçoamento introduzido em implante dentário, cuja função consiste em implante dentário de titânio iluminado com luz UV na superfície do mesmo. 52. In view of this need and commercial opportunity, the aforementioned system was created, more precisely an improvement introduced in a dental implant, whose function consists of a titanium dental implant illuminated with UV light on its surface.
53. Logo, em conformidade com o artigo 9o da Lei da Propriedade Industrial n° 9.279/96 e por todos os aspectos apresentados neste relatório, o objeto do presente pedido de patente se faz merecedor da proteção como Modelo de Utilidade, que ora se pleiteia.
53. Therefore, in accordance with Article 9 of the Industrial Property Law No. 9,279 / 96 and for all aspects in this report, the object of this patent application is worthy of protection as a utility model, which we hereby pleads.
Claims
1. APERFEIÇOAMENTO INTRODUZIDO EM IMPLANTE DENTÁRIO - Trata-se de um implante dentário de dióxido titânio iluminado com luz UV na sua superfície, caracterizado pelo fato de compreender: implante de dióxido de titânio; transformado em camadas na sua superfície através de métodos de eletroquímico, transformando o titânio em dióxido de titânio e sendo utilizado pela luz UV na superfície do implante para aceleramento de sua cicatrização.
1. IMPROVEMENT INTRODUCED IN DENTAL IMPLANT - It is a dental implant of titanium dioxide illuminated with UV light on its surface, characterized by the fact that it comprises: titanium dioxide implant; transformed into layers on its surface through electrochemical methods, transforming titanium into titanium dioxide and being used by UV light on the implant surface to accelerate its healing.
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| PCT/BR2019/050343 WO2021030882A1 (en) | 2019-08-16 | 2019-08-16 | Improvement applied to dental implant |
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| US20190151503A1 (en) * | 2016-03-16 | 2019-05-23 | Id Creations Oy | Coating for improved tissue adhesion |
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