WO2021010924A1 - An effervescent tablet composition of sitagliptin - Google Patents

An effervescent tablet composition of sitagliptin Download PDF

Info

Publication number
WO2021010924A1
WO2021010924A1 PCT/TR2020/050615 TR2020050615W WO2021010924A1 WO 2021010924 A1 WO2021010924 A1 WO 2021010924A1 TR 2020050615 W TR2020050615 W TR 2020050615W WO 2021010924 A1 WO2021010924 A1 WO 2021010924A1
Authority
WO
WIPO (PCT)
Prior art keywords
effervescent tablet
acid
tablet according
sodium
sitagliptin
Prior art date
Application number
PCT/TR2020/050615
Other languages
French (fr)
Inventor
Seval Ataman
Muge ULUSOY BOZYEL
Original Assignee
Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi filed Critical Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi
Priority to EP20841192.6A priority Critical patent/EP3999070A4/en
Publication of WO2021010924A1 publication Critical patent/WO2021010924A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Definitions

  • the present invention relates to an effervescent tablet comprising sitagliptin or a pharmaceutically acceptable salt, solvate or polymorph thereof and at least one pharmaceutically acceptable excipient. Further, the present invention provides a method for the preparation of said tablet.
  • Diabetes mellitus is a group of disorders of carbohydrate metabolism in which the action of insulin is diminished or absent through altered secretion, decreased insulin activity or a combination of both factors.
  • Type 1 and Type 2 There are two main types of diabetes; Type 1 and Type 2:
  • Type 1 diabetes occurs because the insulin-producing cells of the pancreas (beta cells) are damaged. In Type 1 diabetes, the pancreas makes little or no insulin, so sugar cannot get into the body's cells for use as energy. People with Type 1 diabetes must use insulin injections to control their blood glucose.
  • Type 2 diabetes the pancreas makes insulin, but it either doesn't produce enough, or the insulin does not work properly. This diabetes occurs most often in people who are over 40 years old and overweight. Type 2 diabetes may sometimes be controlled with a combination of diet, weight management, and exercise. However, treatment also may include oral glucose-lowering medications or insulin injections.
  • Sitagliptin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It is an oral antihyperglycemic of the dipeptidyl peptidase-4 (DPP-4) inhibitor class.
  • DPP-4 inhibitors work by blocking the action of DPP-4, an enzyme which destroys the hormone incretin.
  • DPP-4 dipeptidyl peptidase-4
  • GLP-1 glucagon-like peptide-1
  • GIP glucose-dependent insulinotropic peptide
  • Sitagliptin works by binding to DPP-4 and preventing it from breaking down the GLP-1 and GIP. This increases the levels of these hormones in the body and so increases their effect on controlling blood sugar.
  • the chemical name of sitagliptin is (R) -4-oxo-4- [3- (trifluoromethyl) -5,6-dihydro [1 ,2,4] triazolo [4,3-a] pyrazin-7 (8H)-yl]-1 - (2,4,5-trifluorophenyl) butan-2-amine), and the chemical structure of sitagliptin is shown in Formula 1.
  • the film-coated tablets of Sitagliptin named as Januvia ® are being marketed by Merck in the USA.
  • the Januvia ® tablet contains 32.13, 64.25, or 128.5 mg of sitagliptin phosphate monohydrate, which is equivalent to 25, 50, or 100 mg, respectively, of free base.
  • the main object of the present invention is to obtain a composition of sitagliptin which overcomes all the above-mentioned problems and brings additional advantages to the relevant prior art.
  • Another object of the present invention is to obtain a formulation by which the rapidly absorbed of sitagliptin and rapidly effective are enhanced.
  • sitagliptin refers to not only sitagliptin, but also its other pharmaceutically acceptable salt, pharmaceutically acceptable solvates, pharmaceutically acceptable hydrates, pharmaceutically acceptable enantiomers, pharmaceutically acceptable derivatives, pharmaceutically acceptable polymorphs or pharmaceutically acceptable prodrugs thereof.
  • Effervescent tablets break down quickly when they are dropped into water or another liquid. Effervescent tablets are uncoated tablets containing substances that react in the presence of water and give off carbon dioxide.
  • Effervescent compositions are an interesting dosage form offering some unique advantages such as administration of an Active Pharmaceutical Ingredient (API) in solution form and taste masking of the API.
  • API Active Pharmaceutical Ingredient
  • Patients benefited by the use of effervescent tablets are the geriatric population, pediatric-population and a large adult population with a gag reflex and/or swallowing difficulty.
  • Effervescent technology provides an alternative to them. Dissolving and break-down of standard tablets also takes additional time in the stomach. In effervescents, ingredients are distributed in the solution and they are not localized at a certain point.
  • sitagliptin or a pharmaceutically acceptable salt, solvate or polymorph thereof is present in an effervescent tablet form, so it is to provide effective and easy use.
  • an effervescent tablet comprises sitagliptin or a pharmaceutically acceptable salt, solvate or polymorph thereof and at least one pharmaceutically acceptable excipient.
  • sitagliptin is present as sitagliptin malate form.
  • sitagliptin malate provides desired stability in the composition.
  • the formulation of the invention was designed without having to compromise on stability to achieve the rapidly absorbed and desired dissolution rate which was linked to the surprisingly coordinated effect of using sitagliptin malate as a source of sitagliptin and using the effervescent tablet form.
  • the amount of sitagliptin malate is between 0.5% and 20.0% or between 0.5% and 10.0% or between 0.5% and 5.0% by weight of the total composition.
  • the effervescent tablet comprises at least one pharmaceutically acceptable excipient which is selected from the group comprising subliming agents, diluents, gas generating agents, acid sources, flavoring agents, super- disintegrants, glidants, lubricants or mixtures thereof.
  • Suitable subliming agents are selected from the group comprising camphor, ammonium bicarbonate, thymol, menthol, vanillin or mixtures thereof.
  • the subliming agents provide the porous structure in the tablet so, the disintegrating time of the effervescent tablet decreases.
  • the amount of the subliming agent is between 0.1% and 40.0% by weight of the total composition.
  • the subliming agent is camphor
  • Suitable diluents are selected from the group comprising mannitol, starch, sorbitol, lactose, lactose monohydrate, dextrose, sucrose, fructose, maltose, xylitol, inositol, kaolin, inorganic salts, calcium salts, polysaccharides, dicalcium phosphate, sodium chloride, dextrates, lactitol, microcrystalline cellulose or mixtures thereof.
  • the amount of the diluent is between 5.0% and 60.0% or between 15.0% and 45.0% or between 20.0% and 35.0% by weight of the total composition.
  • the diluent is mannitol.
  • Gas generating in effervescent tablets is obtained due to the presence of acid and base substances such as carbonates or bicarbonates that react rapidly in the presence of water and release C02 to provide a carbonated or sparkling liquid drink. Due to liberation of C02, the dissolution of API in water as well as taste masking of the API is achieved.
  • Suitable gas generating agents are selected from the group comprising sodium bicarbonate, aluminum potassium sulfate, anhydrous disodium hydrogen phosphate, potassium bicarbonate, anhydrous sodium dihydrogen phosphate, dibasic potassium sulfate, calcium carbonate, monobasic potassium phosphate, sodium acetate, sodium carbonate, sodium glycine carbonate sodium citrate, sodium dihydrogen phosphate dihydrate, tribasic sodium phosphate or mixtures thereof.
  • the amount of the gas generating agent is between 2.0% and 40.0% or between 10.0% and 35.0% or between 20.0% and 30.0% by weight of the total composition.
  • the gas generating agent is sodium bicarbonate.
  • Suitable acid sources are selected from the group comprising citric acid, nicotinic acid, dilute hydrochloric acid, glacial acetic acid, malic acid, ascorbic acid, acetylsalicylic acid, lactic acid, maleic acid, acid, adipic acid, tartaric acid or mixtures thereof.
  • the amount of the acid sources is between 2.0% and 40.0% or between 15.0% and 25.0% by weight of the total composition.
  • the acid source is citric acid.
  • Suitable flavoring agents are selected from the group comprising menthol, peppermint, cinnamon, chocolate, vanillin or fruit essences such as cherry, orange, strawberry, grape, black currant, raspberry, banana, red fruits, wild berries or mixtures thereof.
  • taste masking agents can be used. For example; sodium bicarbonate-citric acid- lemon, sodium bicarbonate-citric acid- orange, sodium bicarbonate-citric acid-cherry or mixtures thereof.
  • the amount of the flavoring is between 0.1% and 10.0% by weight of the total composition.
  • excipients has more importance to obtain the ideal disintegrating time during the shelf life.
  • the choice of the disintegrant has a major role in the manufacture of the effervescent tablets. Therefore, the choice of a suitable disintegrant and an optimal use level are critical to ensure a high disintegration rate.
  • Some disintegrants, also known as super-disintegrants, are particularly effective in inducing rapid tablet disintegration due to the combined effect of swelling and water absorption by the formulation.
  • Suitable super-disintegrants are selected from the group comprising crospovidone, croscarmellose sodium, low-substituted hydroxypropylcellulose, sodium starch glycolate mixtures thereof.
  • the amount of the super-disintegrant is between 1.0% and 30.0% or between 8.0% and 20.0% by weight of the total composition.
  • the super-disintegrant is crospovidone.
  • Suitable lubricants are selected from the group comprising sodium stearyl fumarate, magnesium stearate, calcium stearate, zinc stearate, wax, hydrogenated vegetable oil, sodium chlorate, magnesium lauryl sulfate, sodium oleate, sodium acetate, sodium benzoate, polyethylene glycol, glyceryl palmito sulphate, sodium lauryl sulphate or mixtures thereof.
  • the amount of the lubricants is between 0.05% and 2.0% by weight of the total composition.
  • the lubricant is sodium stearyl fumarate.
  • Suitable glidants are selected from the group comprising colloidal silicon dioxide, talc, aluminum silicate, colloidal silica, calcium silicate, magnesium silicate, magnesium oxide, starch or mixtures thereof.
  • the amount of the glidant is between 0.05% and 2.0% by weight of the total composition.
  • the glidant is colloidal silicon dioxide.
  • the effervescent tablet of the present invention can be prepared by using standard techniques and manufacturing processes well known in the art, such as direct compression, wet or dry granulation, sublimation, hot melt granulation, hot melt extrusion, fluidized bed granulation, extrusion, spheronization, slugging, spray drying.
  • the effervescent tablet of the present invention is prepared by direct compression or wet granulation or dry granulation or sublimation method. It has been found that when the tablet is prepared with these methods, the disintegration time of the effervescent tablet is shortened.
  • Example 1 Effervescent tablet comprising sitagliptin malate
  • Example 2 Effervescent tablet comprising sitagliptin malate
  • a process for preparing the effervescent tablet processed by direct compression in example 1 and example 2 comprises the following steps;
  • sitagliptin malate mannitol, sodium bicarbonate, citric acid, flavoring agent, crospovidone and colloidal silicon dioxide
  • a process for preparing the effervescent tablet processed by wet granulation in example 1 and example 2 comprises the following steps;
  • Example 3 Effervescent tablet comprising sitagliptin malate
  • a process for preparing the effervescent tablet processed by sublimation methods in example 3 comprises the following steps;
  • a process for preparing the effervescent tablet processed by sublimation methods in example 3 comprises the following steps;
  • sitagliptin malate camphor, mannitol, sodium bicarbonate, citric acid, flavoring agent, colloidal silicon dioxide and crospovidone

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to an effervescent tablet comprising sitagliptin or a pharmaceutically acceptable salt, solvate or polymorph thereof and at least one pharmaceutically acceptable excipient. Further, the present invention provides a method for the preparation of said tablet.

Description

DESCRIPTION
AN EFFERVESCENT TABLET COMPOSITION OF SITAGLIPTIN Field of the invention
The present invention relates to an effervescent tablet comprising sitagliptin or a pharmaceutically acceptable salt, solvate or polymorph thereof and at least one pharmaceutically acceptable excipient. Further, the present invention provides a method for the preparation of said tablet.
Background of the invention
Diabetes mellitus is a group of disorders of carbohydrate metabolism in which the action of insulin is diminished or absent through altered secretion, decreased insulin activity or a combination of both factors. There are two main types of diabetes; Type 1 and Type 2:
Type 1 diabetes occurs because the insulin-producing cells of the pancreas (beta cells) are damaged. In Type 1 diabetes, the pancreas makes little or no insulin, so sugar cannot get into the body's cells for use as energy. People with Type 1 diabetes must use insulin injections to control their blood glucose.
In Type 2 diabetes, the pancreas makes insulin, but it either doesn't produce enough, or the insulin does not work properly. This diabetes occurs most often in people who are over 40 years old and overweight. Type 2 diabetes may sometimes be controlled with a combination of diet, weight management, and exercise. However, treatment also may include oral glucose-lowering medications or insulin injections.
Sitagliptin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It is an oral antihyperglycemic of the dipeptidyl peptidase-4 (DPP-4) inhibitor class. DPP-4 inhibitors work by blocking the action of DPP-4, an enzyme which destroys the hormone incretin. There are two types of incretin hormones found in the body, called glucagon-like peptide-1 (GLP-1 ) and glucose-dependent insulinotropic peptide (GIP). These hormones are naturally produced by the body in response to food intake. Their function is to help the body produce more insulin only when it is needed and reduce the amount of glucose being produced by the liver when it is not needed. Sitagliptin works by binding to DPP-4 and preventing it from breaking down the GLP-1 and GIP. This increases the levels of these hormones in the body and so increases their effect on controlling blood sugar. The chemical name of sitagliptin is (R) -4-oxo-4- [3- (trifluoromethyl) -5,6-dihydro [1 ,2,4] triazolo [4,3-a] pyrazin-7 (8H)-yl]-1 - (2,4,5-trifluorophenyl) butan-2-amine), and the chemical structure of sitagliptin is shown in Formula 1.
Figure imgf000003_0001
Formula 1. Sitagliptin
The film-coated tablets of Sitagliptin named as Januvia® are being marketed by Merck in the USA. The Januvia® tablet contains 32.13, 64.25, or 128.5 mg of sitagliptin phosphate monohydrate, which is equivalent to 25, 50, or 100 mg, respectively, of free base.
Given that the greatest problem encountered with solid oral dosage forms of sitagliptin is the lower stability of the product due to its hygroscopic feature, there is still a need in the art for a solid oral dosage form that provides high stability and thus a long shelf life, without compromising its dissolution, disintegration and flowability features while having a safe composition for use in hypertensive and cardiac patients.
Detailed description of the Invention The main object of the present invention is to obtain a composition of sitagliptin which overcomes all the above-mentioned problems and brings additional advantages to the relevant prior art.
Another object of the present invention is to obtain a formulation by which the rapidly absorbed of sitagliptin and rapidly effective are enhanced. The term "sitagliptin" as used throughout the specification refers to not only sitagliptin, but also its other pharmaceutically acceptable salt, pharmaceutically acceptable solvates, pharmaceutically acceptable hydrates, pharmaceutically acceptable enantiomers, pharmaceutically acceptable derivatives, pharmaceutically acceptable polymorphs or pharmaceutically acceptable prodrugs thereof. Effervescent tablets break down quickly when they are dropped into water or another liquid. Effervescent tablets are uncoated tablets containing substances that react in the presence of water and give off carbon dioxide.
Effervescent compositions are an interesting dosage form offering some unique advantages such as administration of an Active Pharmaceutical Ingredient (API) in solution form and taste masking of the API. Patients benefited by the use of effervescent tablets are the geriatric population, pediatric-population and a large adult population with a gag reflex and/or swallowing difficulty.
Taking big tablets or capsules is difficult for the patients. Effervescent technology provides an alternative to them. Dissolving and break-down of standard tablets also takes additional time in the stomach. In effervescents, ingredients are distributed in the solution and they are not localized at a certain point.
According to this embodiment of the present invention, sitagliptin or a pharmaceutically acceptable salt, solvate or polymorph thereof is present in an effervescent tablet form, so it is to provide effective and easy use.
According to this embodiment of the present invention, an effervescent tablet comprises sitagliptin or a pharmaceutically acceptable salt, solvate or polymorph thereof and at least one pharmaceutically acceptable excipient.
According to this embodiment of the present invention, sitagliptin is present as sitagliptin malate form.
Surprisingly, using sitagliptin malate provides desired stability in the composition.
The formulation of the invention was designed without having to compromise on stability to achieve the rapidly absorbed and desired dissolution rate which was linked to the surprisingly coordinated effect of using sitagliptin malate as a source of sitagliptin and using the effervescent tablet form.
According to this embodiment of the present invention, the amount of sitagliptin malate is between 0.5% and 20.0% or between 0.5% and 10.0% or between 0.5% and 5.0% by weight of the total composition.
According to this embodiment of the present invention, the effervescent tablet comprises at least one pharmaceutically acceptable excipient which is selected from the group comprising subliming agents, diluents, gas generating agents, acid sources, flavoring agents, super- disintegrants, glidants, lubricants or mixtures thereof.
Suitable subliming agents are selected from the group comprising camphor, ammonium bicarbonate, thymol, menthol, vanillin or mixtures thereof. The subliming agents provide the porous structure in the tablet so, the disintegrating time of the effervescent tablet decreases.
According to this embodiment of the present invention, the amount of the subliming agent is between 0.1% and 40.0% by weight of the total composition.
According to this embodiment of the present invention, the subliming agent is camphor.
Suitable diluents are selected from the group comprising mannitol, starch, sorbitol, lactose, lactose monohydrate, dextrose, sucrose, fructose, maltose, xylitol, inositol, kaolin, inorganic salts, calcium salts, polysaccharides, dicalcium phosphate, sodium chloride, dextrates, lactitol, microcrystalline cellulose or mixtures thereof.
According to this embodiment of the present invention, the amount of the diluent is between 5.0% and 60.0% or between 15.0% and 45.0% or between 20.0% and 35.0% by weight of the total composition.
According to this embodiment of the present invention, the diluent is mannitol.
Gas generating in effervescent tablets is obtained due to the presence of acid and base substances such as carbonates or bicarbonates that react rapidly in the presence of water and release C02 to provide a carbonated or sparkling liquid drink. Due to liberation of C02, the dissolution of API in water as well as taste masking of the API is achieved.
Suitable gas generating agents are selected from the group comprising sodium bicarbonate, aluminum potassium sulfate, anhydrous disodium hydrogen phosphate, potassium bicarbonate, anhydrous sodium dihydrogen phosphate, dibasic potassium sulfate, calcium carbonate, monobasic potassium phosphate, sodium acetate, sodium carbonate, sodium glycine carbonate sodium citrate, sodium dihydrogen phosphate dihydrate, tribasic sodium phosphate or mixtures thereof.
According to this embodiment of the present invention, the amount of the gas generating agent is between 2.0% and 40.0% or between 10.0% and 35.0% or between 20.0% and 30.0% by weight of the total composition. According to this embodiment of the present invention, the gas generating agent is sodium bicarbonate.
Suitable acid sources are selected from the group comprising citric acid, nicotinic acid, dilute hydrochloric acid, glacial acetic acid, malic acid, ascorbic acid, acetylsalicylic acid, lactic acid, maleic acid, acid, adipic acid, tartaric acid or mixtures thereof.
According to this embodiment of the present invention, the amount of the acid sources is between 2.0% and 40.0% or between 15.0% and 25.0% by weight of the total composition.
According to this embodiment of the present invention, the acid source is citric acid.
Suitable flavoring agents are selected from the group comprising menthol, peppermint, cinnamon, chocolate, vanillin or fruit essences such as cherry, orange, strawberry, grape, black currant, raspberry, banana, red fruits, wild berries or mixtures thereof. Also, taste masking agents can be used. For example; sodium bicarbonate-citric acid- lemon, sodium bicarbonate-citric acid- orange, sodium bicarbonate-citric acid-cherry or mixtures thereof.
According to this embodiment of the present invention, the amount of the flavoring is between 0.1% and 10.0% by weight of the total composition.
The selection of excipients has more importance to obtain the ideal disintegrating time during the shelf life. Especially, the choice of the disintegrant has a major role in the manufacture of the effervescent tablets. Therefore, the choice of a suitable disintegrant and an optimal use level are critical to ensure a high disintegration rate. Some disintegrants, also known as super-disintegrants, are particularly effective in inducing rapid tablet disintegration due to the combined effect of swelling and water absorption by the formulation.
Suitable super-disintegrants are selected from the group comprising crospovidone, croscarmellose sodium, low-substituted hydroxypropylcellulose, sodium starch glycolate mixtures thereof.
According to this embodiment of the present invention, the amount of the super-disintegrant is between 1.0% and 30.0% or between 8.0% and 20.0% by weight of the total composition.
According to this embodiment of the present invention, the super-disintegrant is crospovidone.
Suitable lubricants are selected from the group comprising sodium stearyl fumarate, magnesium stearate, calcium stearate, zinc stearate, wax, hydrogenated vegetable oil, sodium chlorate, magnesium lauryl sulfate, sodium oleate, sodium acetate, sodium benzoate, polyethylene glycol, glyceryl palmito sulphate, sodium lauryl sulphate or mixtures thereof.
According to this embodiment of the present invention, the amount of the lubricants is between 0.05% and 2.0% by weight of the total composition.
According to this embodiment of the present invention, the lubricant is sodium stearyl fumarate.
Suitable glidants are selected from the group comprising colloidal silicon dioxide, talc, aluminum silicate, colloidal silica, calcium silicate, magnesium silicate, magnesium oxide, starch or mixtures thereof.
According to this embodiment of the present invention, the amount of the glidant is between 0.05% and 2.0% by weight of the total composition.
According to this embodiment of the present invention, the glidant is colloidal silicon dioxide.
The effervescent tablet of the present invention can be prepared by using standard techniques and manufacturing processes well known in the art, such as direct compression, wet or dry granulation, sublimation, hot melt granulation, hot melt extrusion, fluidized bed granulation, extrusion, spheronization, slugging, spray drying.
According to this embodiment of the present invention, optionally the effervescent tablet of the present invention is prepared by direct compression or wet granulation or dry granulation or sublimation method. It has been found that when the tablet is prepared with these methods, the disintegration time of the effervescent tablet is shortened.
Example 1 : Effervescent tablet comprising sitagliptin malate
Figure imgf000008_0001
Example 2: Effervescent tablet comprising sitagliptin malate
Figure imgf000008_0002
A process for preparing the effervescent tablet processed by direct compression in example 1 and example 2 comprises the following steps;
- Mixing sitagliptin malate, mannitol, sodium bicarbonate, citric acid, flavoring agent, crospovidone and colloidal silicon dioxide,
- Adding sodium stearyl fumarate and then mixing,
- Pressing to form effervescent tablet in low humidity conditions.
A process for preparing the effervescent tablet processed by wet granulation in example 1 and example 2 comprises the following steps;
- Mixing sitagliptin malate, mannitol, citric acid, flavoring agent and crospovidone, - Granulating the mixture with water,
- Then drying the granules and sieving the granules,
- Adding sodium bicarbonate and colloidal silicon dioxide and then mixing,
- Adding sodium stearyl fumarate and then mixing,
- Pressing to form effervescent tablet in low humidity conditions. Example 3: Effervescent tablet comprising sitagliptin malate
Figure imgf000009_0001
A process for preparing the effervescent tablet processed by sublimation methods in example 3 comprises the following steps;
- Mixing sitagliptin malate, camphor, mannitol, citric acid, flavoring agent and crospovidone,
- Granulating the mixture with water-alcohol mixture,
- Then, drying the granules with vacuum under a certain temperature for a period of time,
- Then, providing sublimation of camphor,
- Obtaining the granules and then sieving,
- Adding sodium bicarbonate and colloidal silicon dioxide then mixing,
- Adding sodium stearyl fumarate and then mixing,
- Pressing to form effervescent tablet in low humidity conditions.
A process for preparing the effervescent tablet processed by sublimation methods in example 3 comprises the following steps;
- Mixing sitagliptin malate, camphor, mannitol, sodium bicarbonate, citric acid, flavoring agent, colloidal silicon dioxide and crospovidone,
- Adding sodium stearyl fumarate and then mixing,
- Pressing to form tablet in low humidity conditions,
- Then, drying the tablets with vacuum under a certain temperature for a period of time,
- Then, providing sublimation of camphor,
- . Thus, effervescent tablets having pours are obtained by this method

Claims

1 . An effervescent tablet comprising sitagliptin or a pharmaceutically acceptable salt, solvate or polymorph thereof and at least one pharmaceutically acceptable excipient.
2. The effervescent tablet according to claim 1 , wherein sitagliptin is present as sitagliptin malate form.
3. The effervescent tablet according to claim 2, wherein the amount of sitagliptin malate is between 0.5% and 20.0% or between 0.5% and 10.0% by weight of the total composition.
4. The effervescent tablet according to claim 3, wherein the amount of sitagliptin malate is between 0.5% and 5.0% by weight of the total composition.
5. The effervescent tablet according to claim 1 , wherein at least one pharmaceutically acceptable excipient is selected from the group comprising subliming agents, diluents, gas generating agents, acid sources, flavoring agents, super-disintegrants, glidants, lubricants or mixtures thereof.
6. The effervescent tablet according to claim 5, wherein the subliming agents are selected from the group comprising camphor, ammonium bicarbonate, thymol, menthol, vanillin or mixtures thereof.
7. The effervescent tablet according to claim 6, wherein the amount of the subliming agent is between 0.1% and 40.0% by weight of the total composition.
8. The effervescent tablet according to claim 5, wherein the diluents are selected from the group comprising mannitol, starch, sorbitol, lactose, lactose monohydrate, dextrose, sucrose, fructose, maltose, xylitol, inositol, kaolin, inorganic salts, calcium salts, polysaccharides, dicalcium phosphate, sodium chloride, dextrates, lactitol, microcrystalline cellulose or mixtures thereof.
9. The effervescent tablet according to claim 8, wherein the amount of the diluent is between 5.0% and 60.0% or between 15.0% and 45.0% by weight of the total composition.
10. The effervescent tablet according to claim 5, wherein the gas generating agents are selected from the group comprising sodium bicarbonate, aluminum potassium sulfate, anhydrous disodium hydrogen phosphate, potassium bicarbonate, anhydrous sodium dihydrogen phosphate, dibasic potassium sulfate, calcium carbonate, monobasic potassium phosphate, sodium acetate, sodium carbonate, sodium glycine carbonate sodium citrate, sodium dihydrogen phosphate dihydrate, tribasic sodium phosphate or mixtures thereof.
1 1. The effervescent tablet according to claim 10, wherein the amount of the gas generating agent is between 2.0% and 40.0% or between 10.0% and 35.0% or between 20.0% and 30.0% by weight of the total composition.
12. The effervescent tablet according to claim 5, wherein the acid sources are selected from the group comprising citric acid, nicotinic acid, dilute hydrochloric acid, glacial acetic acid, malic acid, ascorbic acid, acetylsalicylic acid, lactic acid, maleic acid, acid, adipic acid, tartaric acid or mixtures thereof.
13. The effervescent tablet according to claim 5, wherein the super-disintegrants are selected from the group comprising crospovidone, croscarmellose sodium, low- substituted hydroxypropylcellulose, sodium starch glycolate or mixtures thereof.
14. The effervescent tablet according to claim 13, wherein the amount of the super- disintegrant is between 1.0% and 30.0% or between 8.0% and 20.0% by weight of the total composition.
15. The effervescent tablet according to claim 1 , wherein the effervescent tablet is prepared by direct compression or wet granulation or dry granulation or sublimation method.
PCT/TR2020/050615 2019-07-17 2020-07-10 An effervescent tablet composition of sitagliptin WO2021010924A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP20841192.6A EP3999070A4 (en) 2019-07-17 2020-07-10 An effervescent tablet composition of sitagliptin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2019/10633A TR201910633A1 (en) 2019-07-17 2019-07-17 EFERVESAN TABLET COMPOSITION WITH CYTAGLIPTIN
TR2019/10633 2019-07-17

Publications (1)

Publication Number Publication Date
WO2021010924A1 true WO2021010924A1 (en) 2021-01-21

Family

ID=74209853

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/TR2020/050615 WO2021010924A1 (en) 2019-07-17 2020-07-10 An effervescent tablet composition of sitagliptin

Country Status (3)

Country Link
EP (1) EP3999070A4 (en)
TR (1) TR201910633A1 (en)
WO (1) WO2021010924A1 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010000469A2 (en) * 2008-07-03 2010-01-07 Ratiopharm Gmbh Crystalline salts of sitagliptin
WO2013077819A1 (en) * 2011-11-23 2013-05-30 Mahmut Bilgic Pharmaceutical formulations comprising nateglinide
WO2013115744A1 (en) * 2012-01-31 2013-08-08 Mahmut Bilgic A process for production of pharmaceutical (effervescent) composition comprising alpha - glucosidase inhibitor (e.g. vogliobose and metformin)
US20160367552A1 (en) 2014-02-25 2016-12-22 Cadila Healthcare Limited Pharmaceutical compositions of sitagliptin
US20180360737A1 (en) 2015-12-12 2018-12-20 Steerlife India Private Limited Effervescent compositions of metformin and processes for preparation thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010000469A2 (en) * 2008-07-03 2010-01-07 Ratiopharm Gmbh Crystalline salts of sitagliptin
WO2013077819A1 (en) * 2011-11-23 2013-05-30 Mahmut Bilgic Pharmaceutical formulations comprising nateglinide
WO2013115744A1 (en) * 2012-01-31 2013-08-08 Mahmut Bilgic A process for production of pharmaceutical (effervescent) composition comprising alpha - glucosidase inhibitor (e.g. vogliobose and metformin)
US20160367552A1 (en) 2014-02-25 2016-12-22 Cadila Healthcare Limited Pharmaceutical compositions of sitagliptin
US20180360737A1 (en) 2015-12-12 2018-12-20 Steerlife India Private Limited Effervescent compositions of metformin and processes for preparation thereof

Also Published As

Publication number Publication date
EP3999070A4 (en) 2023-08-16
TR201910633A1 (en) 2021-05-21
EP3999070A1 (en) 2022-05-25

Similar Documents

Publication Publication Date Title
AU753194B2 (en) Fizzy formulations
US20080268046A1 (en) Formulations with Controlled Release of Active Ingredient
NO344546B1 (en) Drug formulations with improved pharmacokinetic properties containing vardenafil
US7465729B2 (en) Methods of treatment of menopause and perimenopause using eszopiclone
EP3731837A2 (en) The combination comprising linagliptin and metformin
EP2700397A1 (en) Effervescent Tablet Formulations of Dapoxetine and a Pde5 Inhibitor
WO2020013777A2 (en) Tablet formulations comprising metformin and sitagliptin
EP2374479A2 (en) Controlled-release composition for producing sustained-release preparation containing udenafil
WO2011136751A2 (en) Water soluble pharmaceutical composition
EP3731828A2 (en) Tablet formulations comprising metformin and sitagliptin processed with hot-melt extrusion
US9833463B2 (en) Sitagliptin tannate complex
EP3999070A1 (en) An effervescent tablet composition of sitagliptin
WO2018185669A1 (en) Effervescent compositions comprising saxagliptin or salt thereof
EP4161525A1 (en) The process for the preparation of a film coated tablet comprising linagliptin and metformin
WO2019132833A1 (en) The modified release combination comprising linagliptin and metformin
EP4167969A1 (en) An orally disintegrating tablet formulation comprising sitagliptin
WO2014027978A1 (en) Chewing gum formulations comprising dapoxetine and tadalafil
WO2005016315A1 (en) Pharmaceutical compositions of nateglinide and a high amount of a water-soluble filler
EP2700398A1 (en) Effervescent Sachet Formulations of Dapoxetine and a Pde5 Inhibitor
WO2023129050A1 (en) A pharmaceutical composition of empagliflozin and linagliptin processed with hot-melt extrusion
KR20220140343A (en) Oral composite formulation comprising evogliptin and metformin and method for preparing the same
EP3781261A2 (en) Oral pharmaceutical compositions comprising dpp-4 inhibitor
EP4171532A1 (en) A stable combination of vildagliptin and metformin hci
EP4034127A1 (en) Effervescent formulations of sapropterin dihydrochloride
TR2021021295A2 (en) A PHARMACEUTICAL COMPOSITION CONTAINING EMPAGLIFLOZIN AND LINAGLIPTIN PREPARED BY HOT MEL EXTRUSION

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 20841192

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2020841192

Country of ref document: EP

Effective date: 20220217