WO2020258734A1 - Dispositif de génération de solitons à polarisation circulaire et système d'imagerie microscopique multiphotonique - Google Patents

Dispositif de génération de solitons à polarisation circulaire et système d'imagerie microscopique multiphotonique Download PDF

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WO2020258734A1
WO2020258734A1 PCT/CN2019/123620 CN2019123620W WO2020258734A1 WO 2020258734 A1 WO2020258734 A1 WO 2020258734A1 CN 2019123620 W CN2019123620 W CN 2019123620W WO 2020258734 A1 WO2020258734 A1 WO 2020258734A1
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Prior art keywords
circularly polarized
soliton
lens
imaging system
optical fiber
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PCT/CN2019/123620
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English (en)
Chinese (zh)
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邱娉
王科
甘梦瑶
仝申
庄自伟
刘鸿吉
程慧
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深圳大学
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Publication of WO2020258734A1 publication Critical patent/WO2020258734A1/fr

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    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/361—Optical details, e.g. image relay to the camera or image sensor
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/28—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00 for polarising
    • G02B27/286—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00 for polarising for controlling or changing the state of polarisation, e.g. transforming one polarisation state into another

Definitions

  • the invention relates to the technical field of optical imaging, in particular to a circularly polarized soliton generator and a multiphoton microscopic imaging system.
  • Soliton refers to light pulses that are transmitted over a long distance while keeping their shape unchanged.
  • a beam of light pulse contains many different frequency components, the frequency is different, and the propagation speed in the medium is also different. Therefore, the light pulse will be dispersed in the optical fiber, making the pulse width wider.
  • the Kerr effect will occur, that is, the refractive index of the medium changes with the light intensity, which leads to self-phase modulation in the light pulse, making the pulse front
  • the resulting phase change causes the frequency to decrease, and the phase change produced by the trailing edge of the pulse causes the frequency to rise, so the leading edge of the pulse propagates slower than the trailing edge, thus narrowing the pulse width.
  • the pulse has an appropriate amplitude, the above two effects can be exactly offset, and the pulse can be transmitted in the fiber with a stable waveform, that is, an optical soliton is formed, which is also called a fundamental-order optical soliton.
  • the pulse amplitude continues to increase, the narrowing effect will exceed the widening effect, and a high-order optical soliton will be formed.
  • the pulse shape transmitted in the fiber will change continuously. First, it will be compressed and narrowed, then split, and the pulse will be periodic at a certain distance. To restore.
  • Optical soliton is formed by two basic physical phenomena in optical fiber, namely group velocity dispersion (GVD) and self-phase modulation (SPM).
  • GMD group velocity dispersion
  • SPM self-phase modulation
  • ⁇ d 1310nm is the zero-dispersion wavelength
  • ⁇ > ⁇ d is called the abnormal dispersion region
  • ⁇ d is called the normal dispersion region.
  • the transmission characteristics of light pulses in the normal and abnormal dispersion regions are different.
  • the abnormal dispersion region the high frequency components (blue shift) and lower frequency components (red shift) of the light pulse are transmitted faster, while in the normal dispersion region, the situation is just the opposite. . Due to different transmission conditions, the group velocity dispersion effect is different, which ultimately leads to the broadening of the optical pulse.
  • the analysis of Gaussian pulses shows that self-phase modulation will cause a red shift in the leading edge of the pulse and a blue shift in the trailing edge.
  • the analysis of pulses of other shapes has similar results.
  • the high-frequency (blueshift) component of the pulse moves faster than the low-frequency (redshift) component
  • the leading edge spectrum of the pulse caused by the self-phase modulation (SPM) effect Red shift slows down the movement of the leading edge of the pulse and speeds up the movement of the trailing edge of the pulse due to spectral blue shift, which makes the pulse narrower, which corresponds to the trend of pulse broadening in the anomalous dispersion region with group velocity dispersion.
  • optical soliton is the precise balance of group velocity dispersion and self-phase modulation effect in the anomalous dispersion region in the fiber.
  • the optical soliton has the following characteristics: ultra-short pulse width (tens of femtoseconds to sub-picosecond order), excellent pulse quality and tunable broadband wavelength Sex. These characteristics make it an ideal light source choice for multiphoton microscopy (MPM).
  • MPM multiphoton microscopy
  • Multiphoton microscopy imaging is a nonlinear optical imaging technique, especially suitable for deep tissue imaging in living body.
  • Multiphoton microscopy imaging technology has been widely used in biology, physiology and medical research in different modalities.
  • the main purpose of the present invention is to provide a circularly polarized soliton generating device and a multiphoton microscopic imaging system, aiming to solve the technical problem of low energy of the optical soliton generated in the prior art.
  • a circularly polarized soliton generator includes a pump laser, a first quarter wave plate, a first focusing lens, and an optical fiber on the same optical path, wherein the linearly polarized light generated by the pump laser passes through the first quarter One of the wave plates is transformed into circularly polarized light, the circularly polarized light is coupled into the optical fiber after passing through the focusing lens, and the circularly polarized light is transformed into a circularly polarized soliton after passing through the optical fiber.
  • the circularly polarized soliton generating device further includes a first collimating lens and a long-pass filter, wherein the circularly polarized soliton is scattered after passing through the collimating lens, and the scattered circularly polarized soliton passes through the long-pass filter. The light sheet is filtered.
  • the optical fiber is a rod-shaped photonic crystal optical fiber.
  • a multiphoton microscopic imaging system comprising a second quarter wave plate, a flat field focusing lens, a dichroic mirror, an objective lens, a photomultiplier tube, and the circularly polarized soliton generator according to any one of claims 1-3 Device; wherein, the circularly polarized soliton generated by the circularly polarized soliton generator is transformed into a linearly polarized soliton after passing through the second quarter wave plate, and the linearly polarized soliton passes through the flat field focusing lens and the dichroic
  • the rear lens is coupled to the objective lens, and the signal is generated by focusing on the object to be detected through the objective lens. The signal is scattered and then passes through the objective lens and the dichroic mirror, and the dichroic mirror couples the signal to the photomultiplier Inside the tube and imaged through the photomultiplier tube.
  • the multiphoton microscopic imaging system further includes a first reflector, and the first reflector is located between the second quarter wave plate and the plan focusing lens.
  • the multiphoton microscopic imaging system further includes a tube lens, and the tube lens is located between the plan focusing lens and the dichroic mirror.
  • the multiphoton microscopy imaging system further includes a second reflector, and the second reflector is located between the tube lens and the dichroic mirror.
  • the above-mentioned circularly polarized soliton generator and multiphoton microscopic imaging system pass the first quarter-wave plate to convert linearly polarized light into circularly polarized light, and then turn the circularly polarized light into circularly polarized soliton after passing through an optical fiber.
  • the energy of the circularly polarized soliton is 1.56 times the energy of the linearly polarized soliton, which enables multiphoton signals to be transmitted farther in the brain, so that humans can further explore the deep tissues of the brain and untie it. The mysterious veil of the brain.
  • Fig. 1 is a schematic diagram of a circularly polarized soliton generator according to an embodiment of the present invention.
  • Fig. 2 is a comparison diagram of the energy of a circularly polarized soliton and a linearly polarized soliton passing through a long-pass filter according to an embodiment of the present invention.
  • Fig. 3(a) is a graph of the relationship between the normalized pump power of the linearly polarized light passing through the first quarter wave plate and the rotation angle of the polarizer according to an embodiment of the present invention.
  • Fig. 3(b) is a diagram of the relationship between the normalized pump power of the circularly polarized light passing through the collimator lens and the rotation angle of the polarizer according to an embodiment of the present invention.
  • Fig. 4 is a schematic diagram of a multiphoton microscopy imaging system according to an embodiment of the present invention.
  • Multiphoton microscopy imaging system 1. Circular polarization soliton generator; 11. Pump laser; 12. First quarter wave plate; 13. First focusing lens; 14. Optical fiber; 15. First alignment Straight lens; 16. Long wave pass filter; 2. Second quarter wave plate; 3. Plan focusing lens; 31. Scanning mirror; 32. Scanning lens; 4. Dichroic mirror; 5. Objective; 6. Photomultiplier tube; 7. First reflector; 8. Tube lens; 9. Second reflector.
  • Fig. 1 is a schematic diagram of a circularly polarized soliton generator according to an embodiment of the present invention.
  • the circularly polarized soliton generator 1 may have a pump laser 11, a first quarter wave plate 12, a first focusing lens 13, and an optical fiber 14 on the same optical path, wherein the pump laser
  • the linearly polarized light generated by 11 is transformed into circularly polarized light after passing through the first quarter wave plate 12, and the circularly polarized light is coupled into the optical fiber 14 after passing through the focusing lens, and the circularly polarized light is transformed into circularly polarized soliton after passing through the optical fiber 14.
  • the linearly polarized light is changed to circularly polarized light through the first quarter wave plate 12, and then the circularly polarized light passes through the optical fiber 14 and becomes a circularly polarized soliton.
  • the energy of the circularly polarized soliton is 1.56 times the energy of the linearly polarized soliton, which enables multiphoton signals to be transmitted farther in the brain, so that humans can further explore the deep tissues of the brain and untie it. The mysterious veil of the brain.
  • i an imaginary unit, representing a differential symbol
  • z represents a transmission distance
  • Ax represents a linearly polarized pulse envelope
  • ⁇ 2 represents group velocity dispersion
  • T represents time
  • ⁇ represents a nonlinear coefficient
  • A+ represents the envelope of the right-handed circularly polarized soliton
  • formula (2) is also applicable to the left-handed polarized soliton impulse (A+ is replaced by A-).
  • the formula (2) can be converted into the energy of a circularly polarized soliton, and its formula is as follows:
  • En+ represents the energy of the circularly polarized soliton
  • En x represents the energy of the linearly polarized soliton
  • the energy of the circularly polarized soliton is 1.56 times the energy of the linearly polarized soliton.
  • the pump laser 11 used in the experiment is (FLCPA-02CSZU, Calmar), and its output laser is linearly polarized light with a wavelength of 1550 nm, pulse The width is 500fs and the repetition frequency is 1MHz.
  • the energy ratio of the circularly polarized soliton to the linearly polarized soliton after passing through the long-pass filter 16 is about 1.56, which is consistent with the theoretical value of 1.5.
  • the following experiments prove that the linearly polarized light generated by the pump laser 11 is converted into circularly polarized light after passing through the first quarter wave plate 12.
  • a polarizer and a power meter are arranged behind the first quarter wave plate 12, the polarizer is rotated, and the power after the polarizer is rotated is measured by the power meter.
  • the power of each angle of circularly polarized light is equal; however, in actual situations, the power of each angle of circularly polarized light will have a certain error.
  • the abscissa is the angle and the ordinate is the normalized power, where the normalized power means that the power of each angle divided by the maximum power is the normalized power of the angle, such as ,
  • the normalized power means that the power of each angle divided by the maximum power is the normalized power of the angle, such as .
  • Now ten power values are measured at 0-360 degrees, and the power measured at 60 degrees is 23.5mw. Among them, the maximum power is 24.5mw, and the normalized power at 60 degrees is 23.5/24.5.
  • the extinction ratio of circularly polarized light is 1, but in actual situations, the extinction ratio of circularly polarized light is close to 1, where the extinction ratio represents the ratio of the minimum power to the maximum power of circularly polarized light at different angles.
  • the measured extinction ratio ERpump 1.06. It can be seen that the linearly polarized light generated by the pump laser 11 is converted into circularly polarized light after passing through the first quarter wave plate 12.
  • the circularly polarized light becomes a circularly polarized soliton after passing through the optical fiber 14.
  • a polarizer and a power meter are arranged behind the first collimating lens 15, the polarizer is rotated, and the polarizer is measured by the power meter. Power.
  • the abscissa is the angle and the ordinate is the normalized power.
  • the measured extinction ratio ERpump 1.03. It can be seen that the circularly polarized light passes through the optical fiber 14 and becomes a circularly polarized soliton.
  • the circularly polarized soliton generator 1 further includes a first collimating lens 15 and a long-wave pass filter 16.
  • the circularly polarized soliton is scattered after passing through the collimating lens, and the scattered circularly polarized soliton passes through the long wave
  • the filter 16 is used for filtering.
  • the long-pass filter 16 can filter circularly polarized solitons other than a specific wavelength. In this embodiment, the wavelength of the circularly polarized soliton allowed by the long-wavelength pass filter 16 is 1617 nm.
  • the optical fiber 14 is a rod-shaped photonic crystal fiber. It can be understood that, in an alternative embodiment, the optical fiber 14 may also be a high-order mode optical fiber, a large mode field optical fiber, or a hollow core optical fiber.
  • Fig. 4 is a schematic diagram of a multiphoton microscopy imaging system according to an embodiment of the present invention.
  • the multiphoton microscopy imaging system 10 can have a second quarter wave plate 2, a flat field focusing lens 3, a dichroic mirror 4, an objective lens 5, a photomultiplier tube 6 and claim 1.
  • the lens 3 and the dichroic mirror 4 are coupled into the objective lens 5, and are focused on the object to be detected through the objective lens 5 to generate a signal. After the signal is scattered, it passes through the objective lens 5 and the dichroic mirror 4 in turn.
  • the dichroic mirror 4 transmits the signal It is coupled to the photomultiplier tube 6 and forms images through the photomultiplier tube 6.
  • the multiphoton microscopy imaging system 10 further includes a first mirror 7, and the first mirror 7 is located between the second quarter wave plate 2 and the flat field focusing lens 3.
  • the multiphoton microscopic imaging system 10 further includes a tube lens 8, and the tube lens 8 is located between the plan focusing lens 3 and the dichroic mirror 4.
  • the multiphoton microscopic imaging system 10 further includes a second mirror 9 located between the tube lens 8 and the dichroic mirror 4.
  • the dichroic mirror 4 can transmit long-wavelength optical solitons and reflect short-wavelength optical solitons.
  • the dichroic mirror 4 can transmit an optical soliton with a wavelength of 1617 nm and reflect an optical soliton with a wavelength of 716 nm.
  • the flat field focusing lens 3 includes an X-axis and Y-axis scanning mirror 31 and a scanning lens 32.
  • the linearly polarized light generated by the pump laser 11 passes through the first quarter-wave plate and then becomes circularly polarized.
  • the circularly polarized light passes through the focusing lens and is coupled into the rod-shaped photonic crystal fiber 14, and the circularly polarized light passes through the rod-shaped photonic crystal fiber 14 to become circularly polarized.
  • the soliton, the circularly polarized soliton is diffused after passing through the collimating lens, the diffused circularly polarized soliton is filtered by the long-pass filter 16, and the filtered circularly polarized soliton is transformed into a linearly polarized soliton through the second quarter wave plate 2 ,
  • the linearly polarized soliton is reflected by the first reflecting mirror 7, the reflected linearly polarized soliton is diffused after passing through the flat field focusing lens 3 and the tube lens 8, and the diffused linearly polarized soliton is reflected by the second reflecting mirror 9 and emitted
  • the linearly polarized soliton is coupled to the objective lens 5 through the dichroic mirror 4, and the linearly polarized soliton is focused on the fluorescent dye of the test object through the objective lens 5, and the fluorescent dye produces a nonlinear effect (the fluorescent molecule absorbs three photons and jumps to the Excited state, the excited state changes to the ground state and emits a photon), thereby

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Abstract

L'invention concerne un dispositif de génération de solitons à polarisation circulaire (1) et un système d'imagerie microscopique multiphotonique. Le dispositif de génération de solitons à polarisation circulaire (1) comprend un laser à pompe (11), une première lame quart d'onde (12), une première lentille de focalisation (13), et une fibre optique (14) disposée sur un même trajet optique, une lumière à polarisation linéaire générée par le laser à pompe (11) étant convertie en une lumière à polarisation circulaire par l'intermédiaire de la première lame quart d'onde (12), la lumière à polarisation circulaire étant couplée dans la fibre optique (14) par l'intermédiaire de la première lentille de focalisation (13), et la lumière à polarisation circulaire étant convertie en un soliton à polarisation circulaire par l'intermédiaire de la fibre optique (14). La lumière polarisée linéairement est convertie en lumière à polarisation circulaire par l'intermédiaire de la première lame quart d'onde (12), puis la lumière à polarisation circulaire est convertie en solitons à polarisation circulaire par l'intermédiaire de la fibre optique (14). Dans les mêmes conditions, l'énergie d'un soliton à polarisation circulaire est de 1,56 fois l'énergie d'un soliton à polarisation linéaire ; ceci permet à un signal multiphotonique d'être transmis plus loin dans le cerveau, permettant ainsi aux êtres humains d'examiner davantage les tissus profonds dans le cerveau, et de démêler la mysmie du cerveau.
PCT/CN2019/123620 2019-06-25 2019-12-06 Dispositif de génération de solitons à polarisation circulaire et système d'imagerie microscopique multiphotonique WO2020258734A1 (fr)

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CN110221445A (zh) * 2019-06-25 2019-09-10 深圳大学 圆偏振孤子产生装置及多光子显微成像系统
CN112113940A (zh) * 2020-08-28 2020-12-22 深圳大学 一种荧光成像装置和荧光成像方法
CN113916855A (zh) * 2021-09-29 2022-01-11 深圳大学 一种显微成像装置

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