WO2020251308A2 - Dispositif d'extraction de mucus gastrique - Google Patents
Dispositif d'extraction de mucus gastrique Download PDFInfo
- Publication number
- WO2020251308A2 WO2020251308A2 PCT/KR2020/007666 KR2020007666W WO2020251308A2 WO 2020251308 A2 WO2020251308 A2 WO 2020251308A2 KR 2020007666 W KR2020007666 W KR 2020007666W WO 2020251308 A2 WO2020251308 A2 WO 2020251308A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- gastric
- wire
- gastric mucus
- tube member
- handle
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B2010/0061—Alimentary tract secretions, e.g. biliary, gastric, intestinal, pancreatic secretions
Definitions
- the present invention relates to a gastric mucus collecting device, and in detail, to a gastric mucus collecting device that can safely and conveniently collect gastric mucus remaining in the stomach wall by entering the stomach along the channel of the endoscope. About.
- mucus is a sticky liquid that covers the mucous membrane of the digestive tract and is secreted from the mucous glands of the human body, and its main components are glycoproteins and water, and its main function is known to protect the mucous membrane from external pathogens, physical damage, or chemical irritation.
- Helicobacter pylori Helicobacter pylori
- Helicobacter bacteria are gram-negative bacteria and are screw-shaped bacteria that live in the stomach (stomach) of animals including humans.
- Helicobacter bacteria are non-invasive bacteria that do not invade the epithelial cells of the stomach, but they cause damage to the epithelial cells of the stomach through several mechanisms. Or it is known to cause MALT lymphoma. In addition, it can also cause idiopathic thrombocytopenia purpura and iron deficiency anemia in children.
- the stomach (stomach) is in a strong acidic state (pH 1 ⁇ 2) due to stomach acid, and bacteria cannot live for a long time, but Helicobacter bacteria can survive because they inhabit the mucus layer, not the gastric cavity. This is because the mucous layer is protected from gastric acid, and at the same time, it is able to neutralize gastric acid by decomposing urea using its own secreted urease to generate ammonia.
- invasive and non-invasive methods Methods of detecting or diagnosing Helicobacter bacteria can be largely divided into invasive and non-invasive methods.
- the invasive method is a method that directly uses the gastric mucosa tissue collected through an endoscope, such as histology, rapid urease test, bacterial culture test, or polymerase chain reaction (PCR). And the molecular biological test method used.
- Non-invasive methods include urea breath test, serology, stool antigen test, or salivary and urine antibody assay.
- the rapid urease test is a method of collecting gastric mucosa tissue and putting it into a test instrument containing urea to determine whether or not H.
- Ammonia generated by Helicobacter bacteria is used to change the pH, and the sensitivity of the test is about 85-98% and the specificity is about 90% or more.
- This method is a simple, fast and accurate invasive test that can detect infections of Helicobacter bacteria.
- the size of the tissue is only 2-3 mm, so the mucus layer contained therein is even smaller.
- Helicobacter bacteria are present in the mucous layer of tissues, even in the state of being infected with Helicobacter, if the number of Helicobacters contained in the collected mucus layer is small, false negatives may occur in the rapid urease test.
- Helicobacter is not evenly distributed in the gastric mucosa, such as atrophic gastritis and intestinal epithelial metabolism, there is a possibility of false negative.
- blood may appear on the specimen during the tissue collection process, or false positives may appear due to xylocaine or bacterial contamination in the oral cavity.
- the present invention is easy to insert into the stomach (stomach) through an endoscope, and not only can easily collect a gastric mucus sample by a selectively detachable gastric mucus collecting member, but also by an adapter that protects the gastric mucus collecting member. Its purpose is to provide a gastric mucus collecting device that can protect the absorber from which the gastric mucus is collected from contamination from other factors.
- the gastric mucus collecting device includes a tube member having a hollow inside along the length direction, and is inserted into the hollow of the tube member, a mounting member is provided at the tip, and the length of the tube member by operation of the user
- a wire selectively moving forward or backward along the line, while provided at the rear end of the tube member, is coupled to the rear end of the wire, and is mounted on a handle part for selectively moving forward or backward, and the mounting member, It includes a gastric mucus collecting member for collecting the gastric mucus by interviewing the gastric wall of the wire through the advancement (stomach).
- the gastric mucus collecting device may further include an adapter coupled to the front end of the tube member to protect the gastric mucus collecting member.
- the mounting member according to the present invention forms a mounting groove along the circumference of the streamlined body, so that the mounting portion on which the gastric mucus collecting member is mounted forms a conical shape.
- the gastric mucus collecting member absorbs gastric mucus by interfacing with a fixing part that is mounted corresponding to a mounting member provided at the tip of the wire, and connected to the tip of the fixing part, and interviews the stomach wall. It is provided with an absorbing portion.
- the fixing unit according to the present invention has a plurality of elastic locking rings arranged symmetrically or radially with respect to the center, so that the mounting portion of the wire is positioned between the plurality of locking rings, so that the gastric mucus collecting member is mounted.
- the absorbent part according to the present invention is formed of any one of a fabric piece, a cotton ball, and a sponge.
- a polymer film may be formed on the inner peripheral surface of the tube member and/or the surface of the wire according to the present invention.
- the handle portion according to the present invention is connected to the first handle member connected to the rear end of the tube member and the last end of the wire, and moves along the length of the first handle member from the outer peripheral surface of the first handle member.
- a second handle member provided on the rear side of the second handle member and providing frictional resistance to prevent the second handle member from moving freely.
- FIG. 1 is an exemplary view showing a state in which a gastric mucus collecting device according to an embodiment of the present invention is applied to an endoscope.
- FIG 2 is an exemplary view showing a gastric mucus collecting device according to an embodiment of the present invention.
- FIG 3 is an exemplary view showing an operating state of a wire and an adapter according to an embodiment of the present invention.
- FIG. 4 is an exemplary view showing a state in which a gastric mucus collecting member according to an embodiment of the present invention is mounted on a mounting portion of a wire.
- FIG 5 is an exemplary view showing an operating state of a handle according to an embodiment of the present invention.
- the gastric mucus collecting device includes a tube member having a hollow inside along the length direction, and is inserted into the hollow of the tube member, a mounting member is provided at the tip, and the length of the tube member by operation of the user
- a wire selectively moving forward or backward along the line, while provided at the rear end of the tube member, is coupled to the rear end of the wire, and is mounted on a handle part for selectively moving forward or backward, and the mounting member, It includes a gastric mucus collecting member for collecting the gastric mucus by interviewing the gastric wall of the wire through the advancement (stomach).
- the present invention relates to a gastric mucus collecting device that can safely and conveniently collect gastric mucus remaining on the stomach wall by entering into the stomach along the channel of the endoscope. As follows.
- the gastric mucus collecting device is to enter into the stomach along the channel 11 of the endoscope 10, the tube member 100, and the wire ( 200), a handle part 300, and a gastric mucus collecting member 400, wherein the tube member 100 has a shape like a conventional tube having a hollow 110 formed therein along the length direction,
- the tube member 100 may form a corrugation along the outer surface in the longitudinal direction so that the flexibility is doubled in the longitudinal direction, and a cylindrical tip member 120 is provided at the tip.
- a coupling portion 121 to which the adapter 500 is coupled is formed at the front end of the tip member 120, and a coupling step for limiting the coupling depth of the adapter 500 is formed at the rear end of the coupling portion 121 (122) is formed, and a pair of coupling protrusions 123 are formed on the outer circumferential surface of the coupling part 121 to protrude on positions facing each other, when the adapter 500 is coupled to the coupling part 121 , While guiding the adapter 500, the separation of the adapter 500 is regulated.
- the adapter 500 has a tube shape having a hollow inside, has the same diameter as the tube member 100, and the coupling portion 121 is coupled to the rear inner circumferential surface.
- a pair of coupling grooves 501 corresponding to the protrusion 123 are formed on positions facing each other.
- the defect groove 501 is formed in a' ⁇ ' shape whose tip is bent in one direction.
- the defect grooves 501 of the adapter 500 are formed with the coupling protrusions 123 of the coupling portion 121
- the coupling protrusions 123 in the defect grooves 501 correspond to each other, and the adapter ( 500) is coupled to the coupling portion 121 of the tip member 120, and when the movement is completed, the adapter 500 is rotated in the direction in which the coupling groove 501 is bent to prevent separation of the adapter 500 Make it possible.
- a wire 200 is inserted into the hollow 110 of the tube member 100, the wire 200 has a mounting member 210 at its front end, and the tube member 100 by user's manipulation Selectively move forward or backward along the length of.
- the wire 200 is woven into one of a plurality of wires, and when the wire 200 moves, a polymer is formed on the inner surface of the hollow 110 of the tube member 100 and/or the surface of the wire to reduce frictional resistance. ) It is preferable to form a film.
- the operation of the wire 200 is made by the handle portion 300, the handle portion 300 is provided at the rear end of the tube member 100, the rear end of the wire 200 is coupled, the The wire 200 is selectively moved forward or backward.
- the handle 300 is formed in a cylinder and piston structure like a syringe, and the last end of the tube member 100
- the first handle member 310 serving as a piston is coupled to the first handle member 310
- the rear end of the wire 200 is coupled to the second handle member 320 serving as a cylinder.
- a gripping hole 311 through which the thumb is gripped is formed at the rear end of the first gripping member 310, and is moved along the length of the first gripping member 310 from the outer circumferential surface of the first gripping member 310
- a resistor 322 providing frictional resistance to prevent the second gripping member 320 from freely moving is provided on the rear side. Equipped.
- the last end of the wire 200 is coupled to the resistor 322.
- the user holds the index finger and the middle finger in the gripping groove 321 of the second gripping member 320 while gripping with the thumb in the gripping hole 311 of the first gripping member 310 to move the wire 200
- the wire 200 moves along the hollow 110 of the tube member 100 by holding the finger and moving the second handle member 320 with the index finger and the middle finger based on the thumb. do.
- the mounting member 210 of the wire 200 is equipped with a gastric slime collecting member 400, the gastric slime collecting member 400 with reference to FIG. 4 is detachable from the mounting member 210 of the wire 200 As possible, it is mounted on the mounting member 210 of the wire 200, and the gastric mucus is collected by interviewing the stomach wall as the wire 200 advances.
- the mounting member 210 has a streamlined shape having a length in the front and rear direction, and the rear end is coupled to the front end of the wire 200 ,
- the tip of the mounting portion on which the gastric slime collecting member 400 is mounted has a conical shape, so that the gastric slime collecting member 400 is easily mounted. While doing so, make sure it is not easy to leave.
- the diameter of the mounting member 210 may be formed smaller than the inner diameter of the tube member 100 and may be located inside the tip of the tube member 100.
- a stopper 101 may be formed inside the tip of the tube member 100 so as to prevent the mounting member 210 from entering the tube member 100 any more from the corresponding position.
- the gastric mucus collecting member 400 mounted on the mounting member 210 of the wire 200 includes a fixing part 410 and an absorbing part 420, the fixing part 410 is the wire 200 Hang the mounting member 210 provided at the tip of the slime collecting member 400 to form a locking ring 411 having elasticity so that the gastric slime collecting member 400 is mounted.
- the locking ring 411 is arranged symmetrically or radially in two or more, while the ring formed at the rear end protrudes toward the center, so that the ring of the locking ring 411 is seated and caught in the mounting groove 211 .
- the conical mounting portion of the mounting member 210 is inserted into the fixing portion 410 of the gastric slime collecting member 400, and the gastric slime collecting member 400 is mounted on the mounting member 210.
- the locking ring 411 has its own elasticity, and when the gastric mucus collecting member 400 is mounted on the mounting member 210, the locking ring 411 of the fixing part 410 opens outward. When it is possible to enter the ground, and when the locking ring 411 of the fixing part 410 is seated in the mounting groove 211 of the mounting member 210, it is closed and the gastric mucus collecting member in the mounting member 210 ( 400) does not easily deviate.
- the space of the fixing portion 410 formed by the locking rings 411 is formed in a shape corresponding to the mounting member 210, so that the gastric mucus collecting member 400 is in the longitudinal direction of the wire 200 Maintain your posture in a straight line.
- an absorbing part 420 is provided at the tip of the fixing part 410, which absorbs gastric mucus by making an interview with the stomach wall.
- the absorbent part 420 is preferably formed of any one of a fabric piece, a cotton ball, and a sponge, and the absorbent part 420 is formed in a form in which a plurality of flesh, such as a fan, is diffused and deployed from the rear center to the front, When collecting gastric mucus, it is possible to collect gastric mucus without clumping or drying under pressure, maintaining its shape.
- the tube member 100 is inserted into the channel of the endoscope and guided by the endoscope channel to the tube member 100 The tip of the stomach enters into the stomach.
- the wire 200 is accommodated in the hollow 110 of the tube member 100, and the mounting member 210, which is the tip of the wire 200, has a gastric slime collecting member 400 that absorbs and collects gastric slime.
- the adapter 500 is coupled to the tip member 120 of the tube member 100 so that the gastric mucus collecting member 400 is not contaminated.
- the tip of the tube member 100 reaches a corresponding position in the stomach, the length of the first handle member 310 among the handle parts 300 coupled to the rear of the tube member 100 Accordingly, by moving the second handle member 320 toward the front end, the wire 200 connected to the second handle member 320 is moved toward the front end, so that the gastric mucus collecting member 400 is inside the adapter 500 It appears outside.
- the absorbent part 420 of the gastric mucus collecting member 400 is above ( stomach) in an interview with the inner wall, the absorption part 420 absorbs gastric mucus, so that gastric mucus is collected, and when gastric mucus is collected by the absorption part 420, the handle part 300 again Of the second handle member 320 is moved to the rear side along the length of the first handle member 310, the wire 200 connected to the second handle member 320 is moved to the rear side, the wire 200 ) By the movement of the gastric mucus collecting member 400 is again accommodated into the adapter 500.
- the tube member 100 is removed from the endoscope channel. At this time, in the process of pulling out the tube member 100 The gastric mucus collecting member 400 in which mucus has been collected is not contaminated by other factors by the adapter 500 and comes out to the outside.
- the adapter 500 coupled to the tip member 120 of the tube member 100 is separated, and then the gastric slime collecting member 400 Is separated from the mounting member 210, which is the tip of the wire 200, to obtain the gastric slime collecting member 400, and the gastric slime test can be performed using the obtained gastric slime collecting member 400.
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- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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Abstract
La présente invention concerne un dispositif d'extraction de mucus gastrique comprenant : un élément tubulaire qui est inséré dans un estomac par guidage d'un canal d'endoscope et possède une partie creuse formée en son sein le long de la direction longitudinale ; un fil qui est inséré dans la partie creuse de l'élément tubulaire, possède une partie de montage disposée à l'extrémité avant de celui-ci, et se déplace sélectivement vers l'avant ou vers l'arrière en fonction de la longueur de l'élément tubulaire par une mise en œuvre d'un utilisateur ; une partie poignée qui est disposée à l'extrémité arrière de l'élément tubulaire et à laquelle est accouplée l'extrémité arrière du fil, de sorte que la partie poignée permet au fil de se déplacer sélectivement vers l'avant ou vers l'arrière ; et un élément d'extraction de mucus gastrique qui est monté sur l'élément de montage et vient en contact de surface avec une paroi d'estomac par déroulement du fil pour extraire le mucus gastrique, le dispositif d'extraction de mucus gastrique pouvant entrer dans un estomac le long d'un canal d'un endoscope et extraire de manière sûre et pratique le mucus gastrique restant sur une paroi de l'estomac.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2019-0069430 | 2019-06-12 | ||
KR1020190069430A KR20200142323A (ko) | 2019-06-12 | 2019-06-12 | 위점액 채취장치 |
Publications (2)
Publication Number | Publication Date |
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WO2020251308A2 true WO2020251308A2 (fr) | 2020-12-17 |
WO2020251308A3 WO2020251308A3 (fr) | 2021-03-25 |
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ID=73782185
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/KR2020/007666 WO2020251308A2 (fr) | 2019-06-12 | 2020-06-12 | Dispositif d'extraction de mucus gastrique |
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KR (1) | KR20200142323A (fr) |
WO (1) | WO2020251308A2 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113081073A (zh) * | 2021-04-21 | 2021-07-09 | 何梦璇 | 幽门螺杆菌智能取样检测仪及其取样方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4318414A (en) * | 1977-05-09 | 1982-03-09 | Ovutime, Inc. | Probe for obtaining cervical mucus |
JP4217343B2 (ja) * | 1999-06-02 | 2009-01-28 | オリンパス株式会社 | 内視鏡用粘液採取装置 |
US7727247B2 (en) * | 2002-08-21 | 2010-06-01 | Olympus Corporation | Living tissue ligation device |
US9662096B2 (en) * | 2014-05-01 | 2017-05-30 | Diomics Corporation | Devices and kits for collection, storage and analysis of samples and methods of production and use thereof |
KR101839935B1 (ko) * | 2016-12-16 | 2018-03-19 | 한국항공우주연구원 | 내시경 생검 겸자 및 내시경 생검 겸자의 멸균 방법 |
-
2019
- 2019-06-12 KR KR1020190069430A patent/KR20200142323A/ko not_active Application Discontinuation
-
2020
- 2020-06-12 WO PCT/KR2020/007666 patent/WO2020251308A2/fr active Application Filing
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113081073A (zh) * | 2021-04-21 | 2021-07-09 | 何梦璇 | 幽门螺杆菌智能取样检测仪及其取样方法 |
Also Published As
Publication number | Publication date |
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KR20200142323A (ko) | 2020-12-22 |
WO2020251308A3 (fr) | 2021-03-25 |
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