WO2020243107A1 - Design of aerosol system and interface to deliver clinically and economically feasible inhaled dose with neonatal cpap device - Google Patents

Design of aerosol system and interface to deliver clinically and economically feasible inhaled dose with neonatal cpap device Download PDF

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Publication number
WO2020243107A1
WO2020243107A1 PCT/US2020/034576 US2020034576W WO2020243107A1 WO 2020243107 A1 WO2020243107 A1 WO 2020243107A1 US 2020034576 W US2020034576 W US 2020034576W WO 2020243107 A1 WO2020243107 A1 WO 2020243107A1
Authority
WO
WIPO (PCT)
Prior art keywords
aerosolization
medicament
patient
aerosol
baffle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2020/034576
Other languages
English (en)
French (fr)
Inventor
James B. Fink
Andrew R. Clark
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stamford Devices Ltd
Original Assignee
Stamford Devices Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stamford Devices Ltd filed Critical Stamford Devices Ltd
Priority to CN202080038393.9A priority Critical patent/CN113874059B/zh
Priority to EP20732433.6A priority patent/EP3976143B1/en
Priority to CA3137299A priority patent/CA3137299A1/en
Priority to AU2020285714A priority patent/AU2020285714B2/en
Priority to ES20732433T priority patent/ES2986012T3/es
Priority to JP2021569474A priority patent/JP7797201B2/ja
Publication of WO2020243107A1 publication Critical patent/WO2020243107A1/en
Anticipated expiration legal-status Critical
Priority to JP2024184376A priority patent/JP2025015549A/ja
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/003—Particle size control by passing the aerosol trough sieves or filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0085—Inhalators using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/08—Bellows; Connecting tubes ; Water traps; Patient circuits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/18—General characteristics of the apparatus with alarm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/10—Trunk
    • A61M2210/1025—Respiratory system

Definitions

  • FIG. 19 is a flowchart of a process of initializing an aerosolization system.
  • FIG. 1A shows a cross-sectional view of the aerosolization system of FIG. 1.
  • an aerosol generator 112 of the aerosolization device 100 is shown positioned at the first end of the aerosol chamber 102 such that any medicament that is aerosolized by the an aerosol generator 112 is introduced into the aerosolization chamber 102.
  • the aerosol generator 112 may include a mesh that is configured to generate aerosol particles.
  • connecting the respiration sensor to the pod includes inserting a connection, such as a slip Luer, into a port of the pod 810.
  • a connection such as a slip Luer
  • the respiration sensor 814 may be adhered and/or otherwise affixed to the patient’s abdomen to begin sensing inspiration cycles
  • the aerosolization device 1500 may also include one or more straps or other restraints 1502 that enable the aerosolization device 1500 to be secured with the infant’s head and airways. Additionally, the aerosolization device 1500 may include a foam pad 1504 that is designed to help maintain the aerosolization device 1500 at a proper position and orientation with the infant, regardless of the movement or orientation (back, side, stomach) of the infant. The foam pad 1504 may include multiple layers of peel able foam, allowing the layers to be peeled off and/or otherwise removed to adjust a distance between the aerosolization device 1500 and the infant’s head. Oftentimes, the foam pad 1504 may include a curved surface that is designed to match or substantially match a contour of the infant’s head. The aerosolization device 1500 may be constructed of sufficiently light materials (such as medical-grade plastic foam) that allow the infant to move around without causing the aerosolization device 1500 to shift out of proper position.
  • sufficiently light materials such as medical-grade plastic foam

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
PCT/US2020/034576 2019-05-24 2020-05-26 Design of aerosol system and interface to deliver clinically and economically feasible inhaled dose with neonatal cpap device Ceased WO2020243107A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CN202080038393.9A CN113874059B (zh) 2019-05-24 2020-05-26 以新生儿cpap装置临床且经济上可行地输送吸入剂量的气溶胶系统和接口的设计
EP20732433.6A EP3976143B1 (en) 2019-05-24 2020-05-26 Design of aerosol system and interface to deliver clinically and economically feasible inhaled dose with neonatal cpap device
CA3137299A CA3137299A1 (en) 2019-05-24 2020-05-26 Design of aerosol system and interface to deliver clinically and economically feasible inhaled dose with neonatal cpap device
AU2020285714A AU2020285714B2 (en) 2019-05-24 2020-05-26 Design of aerosol system and interface to deliver clinically and economically feasible inhaled dose with neonatal CPAP device
ES20732433T ES2986012T3 (es) 2019-05-24 2020-05-26 Diseño de un sistema de aerosol y una interfaz para administrar una dosis inhalada clínica y económicamente factible con un dispositivo CPAP neonatal
JP2021569474A JP7797201B2 (ja) 2019-05-24 2020-05-26 新生児ｃｐａｐ装置において臨床的および経済的に実現可能な吸入用量を送達するためのエアロゾルシステムおよびインターフェースの設計
JP2024184376A JP2025015549A (ja) 2019-05-24 2024-10-18 新生児ｃｐａｐ装置において臨床的および経済的に実現可能な吸入用量を送達するためのエアロゾルシステムおよびインターフェースの設計

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962852862P 2019-05-24 2019-05-24
US62/852,862 2019-05-24

Publications (1)

Publication Number Publication Date
WO2020243107A1 true WO2020243107A1 (en) 2020-12-03

Family

ID=71083772

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2020/034576 Ceased WO2020243107A1 (en) 2019-05-24 2020-05-26 Design of aerosol system and interface to deliver clinically and economically feasible inhaled dose with neonatal cpap device

Country Status (7)

Country Link
EP (1) EP3976143B1 (https=)
JP (2) JP7797201B2 (https=)
CN (1) CN113874059B (https=)
AU (1) AU2020285714B2 (https=)
CA (1) CA3137299A1 (https=)
ES (1) ES2986012T3 (https=)
WO (1) WO2020243107A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4374903A1 (en) 2022-11-24 2024-05-29 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Administering an aerosol to a patient

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5758637A (en) 1995-08-31 1998-06-02 Aerogen, Inc. Liquid dispensing apparatus and methods
US6235177B1 (en) 1999-09-09 2001-05-22 Aerogen, Inc. Method for the construction of an aperture plate for dispensing liquid droplets
US20050229926A1 (en) * 2004-04-20 2005-10-20 Aerogen, Inc. Method and composition for the treatment of lung surfactant deficiency or dysfunction
WO2011038901A1 (en) * 2009-09-29 2011-04-07 Activaero Gmbh Improved method for treatment of patients with cystic fibrosis
US20150336115A1 (en) 2014-05-23 2015-11-26 Stamford Devices Limited Method for producing an aperture plate
US20160130715A1 (en) 2010-12-28 2016-05-12 Stamford Devices Limited Photodefined aperture plate and method for producing the same

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US6606992B1 (en) * 1999-06-30 2003-08-19 Nektar Therapeutics Systems and methods for aerosolizing pharmaceutical formulations
US6530370B1 (en) * 1999-09-16 2003-03-11 Instrumentation Corp. Nebulizer apparatus
EP1474198B1 (en) * 2002-01-15 2015-12-30 Novartis AG System for clearing aerosols from the effective anatomic dead space
CA2561845C (en) * 2004-04-02 2014-03-25 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Aerosol delivery systems and methods
AU2005234774B2 (en) 2004-04-20 2011-01-20 Novartis Ag Aerosol delivery apparatus for pressure assisted breathing
US20130146053A1 (en) * 2008-03-17 2013-06-13 Discovery Laboratories, Inc. Ventilation circuit adaptor and proximal aerosol delivery system
ES2565219T3 (es) 2008-03-17 2016-04-01 Discovery Laboratories, Inc. Adaptador de circuito de ventilación y sistema proximal de administración de aerosol
DE102008022987A1 (de) 2008-05-09 2009-11-12 Pari Pharma Gmbh Vernebler für Beatmungsmaschinen und Beatmungsmaschine mit einem solchen Vernebler
WO2011057235A2 (en) * 2009-11-09 2011-05-12 Virginia Commonwealth University Improved delivery of submicrometer and nonometer aerosols to the lungs using hygroscopic excipients or dual stream nasal delivery
US8778383B2 (en) * 2011-06-07 2014-07-15 Parion Sciences, Inc. Methods of treatment
NO2709641T3 (https=) * 2014-03-10 2018-05-12
US20160030701A1 (en) * 2014-07-29 2016-02-04 Peter Edenhoffer Positive pressure inspiration device for delivery of medicaments
CN104147674A (zh) * 2014-09-03 2014-11-19 张春桂 湿化雾化吸氧装置
US9352108B1 (en) * 2015-10-15 2016-05-31 George Ashford Reed Respiratory medicament nebulizer system
US11173269B2 (en) 2016-08-15 2021-11-16 Fisher & Paykel Healthcare Limited Adaptor for respiratory assistance systems
JP7258771B2 (ja) 2017-03-23 2023-04-17 スタムフォード・ディバイセズ・リミテッド エアロゾル送達装置
AU2018240521B2 (en) 2017-03-23 2023-06-01 Stamford Devices Ltd Retrofit aerosol delivery system and method
CN109432556B (zh) * 2018-11-20 2019-09-03 王芳 一种智能儿科用药物雾化器及其使用方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5758637A (en) 1995-08-31 1998-06-02 Aerogen, Inc. Liquid dispensing apparatus and methods
US6235177B1 (en) 1999-09-09 2001-05-22 Aerogen, Inc. Method for the construction of an aperture plate for dispensing liquid droplets
US20050229926A1 (en) * 2004-04-20 2005-10-20 Aerogen, Inc. Method and composition for the treatment of lung surfactant deficiency or dysfunction
WO2011038901A1 (en) * 2009-09-29 2011-04-07 Activaero Gmbh Improved method for treatment of patients with cystic fibrosis
US20160130715A1 (en) 2010-12-28 2016-05-12 Stamford Devices Limited Photodefined aperture plate and method for producing the same
US20150336115A1 (en) 2014-05-23 2015-11-26 Stamford Devices Limited Method for producing an aperture plate

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4374903A1 (en) 2022-11-24 2024-05-29 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Administering an aerosol to a patient
WO2024110588A1 (en) 2022-11-24 2024-05-30 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Administering an aerosol to a patient

Also Published As

Publication number Publication date
CA3137299A1 (en) 2020-12-03
AU2020285714B2 (en) 2025-05-22
AU2020285714A1 (en) 2022-01-06
JP2025015549A (ja) 2025-01-30
CN113874059A (zh) 2021-12-31
JP2022533446A (ja) 2022-07-22
JP7797201B2 (ja) 2026-01-13
EP3976143A1 (en) 2022-04-06
EP3976143B1 (en) 2024-07-17
ES2986012T3 (es) 2024-11-08
CN113874059B (zh) 2025-04-08

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