WO2020239635A1 - Dispositif de distribution d'aérosol - Google Patents

Dispositif de distribution d'aérosol Download PDF

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Publication number
WO2020239635A1
WO2020239635A1 PCT/EP2020/064318 EP2020064318W WO2020239635A1 WO 2020239635 A1 WO2020239635 A1 WO 2020239635A1 EP 2020064318 W EP2020064318 W EP 2020064318W WO 2020239635 A1 WO2020239635 A1 WO 2020239635A1
Authority
WO
WIPO (PCT)
Prior art keywords
aerosol
aerosol generator
delivery device
mass
precursor
Prior art date
Application number
PCT/EP2020/064318
Other languages
English (en)
Inventor
Andrew Austin
Tamas Sajtos
Alan Cook
Original Assignee
Nerudia Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP19176368.9A external-priority patent/EP3741411A1/fr
Priority claimed from EP19176412.5A external-priority patent/EP3741410A1/fr
Priority claimed from EP19176388.7A external-priority patent/EP3741230A1/fr
Application filed by Nerudia Limited filed Critical Nerudia Limited
Priority to EP20727294.9A priority Critical patent/EP3975772A1/fr
Publication of WO2020239635A1 publication Critical patent/WO2020239635A1/fr
Priority to US17/533,736 priority patent/US20220079233A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/30—Devices using two or more structurally separated inhalable precursors, e.g. using two liquid precursors in two cartridges
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/10—Devices using liquid inhalable precursors
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/50—Control or monitoring

Definitions

  • the present disclosure relates to an aerosol delivery device and particularly, although not exclusively, an aerosol delivery device comprising a switching device configured to provide relative movement between an aerosol generator and an airflow passage.
  • the present disclosure also relates to an aerosol delivery device and particularly, although not exclusively, an aerosol delivery device operable in a normal mode and a boost mode.
  • the disclosure also relates to an aerosol delivery device and particularly, although not exclusively, to an aerosol delivery device comprising a supporting portion connecting a transfer element to a switch such that movement of the switch causes movement of the transfer element.
  • a smoking-substitute device is an electronic device that permits the user to simulate the act of smoking by producing an aerosol mist or vapour that is drawn into the lungs through the mouth and then exhaled.
  • the inhaled aerosol mist or vapour typically bears nicotine and/or other flavourings without the odour and health risks associated with traditional smoking and tobacco products.
  • the user experiences a similar satisfaction and physical sensation to those experienced from a traditional smoking or tobacco product, and exhales an aerosol mist or vapour of similar appearance to the smoke exhaled when using such traditional smoking or tobacco products.
  • a smoking substitute device is the so-called“vaping” approach, in which a vaporisable liquid, typically referred to (and referred to herein) as“e-liquid”, is heated by a heating device to produce an aerosol vapour which is inhaled by a user.
  • the e-liquid typically includes a base liquid as well as nicotine and/or flavourings.
  • the resulting vapour therefore also typically contains nicotine and/or flavourings.
  • the base liquid may include propylene glycol and/or vegetable glycerine.
  • a typical vaping smoking substitute device includes a mouthpiece, a power source (typically a battery), a tank for containing e-liquid, as well as a heating device.
  • a power source typically a battery
  • a tank for containing e-liquid as well as a heating device.
  • electrical energy is supplied from the power source to the heating device, which heats the e-liquid to produce an aerosol (or“vapour”) which is inhaled by a user through the mouthpiece.
  • Vaping smoking substitute devices can be configured in a variety of ways.
  • there are“closed system” vaping smoking substitute devices which typically have a sealed tank and heating element.
  • the tank is pre-filled with e liquid and is not intended to be refilled by an end user.
  • One subset of closed system vaping smoking substitute devices include a main body which includes the power source, wherein the main body is configured to be physically and electrically coupled to a consumable including the tank and the heating element.
  • the consumable may also be referred to as a cartomizer. In this way, when the tank of a consumable has been emptied, that consumable is disposed of.
  • the main body can be reused by connecting it to a new, replacement, consumable.
  • vaping smoking substitute devices are completely disposable, and intended for one-use only.
  • vaping smoking substitute devices typically have a tank that is configured to be refilled by a user. In this way the device can be used multiple times.
  • An example vaping smoking substitute device is the mybluTM e-cigarette.
  • the mybluTM e cigarette is a closed system device which includes a main body and a consumable.
  • the main body and consumable are physically and electrically coupled together by pushing the consumable into the main body.
  • the main body includes a rechargeable battery.
  • the consumable includes a mouthpiece, a sealed tank which contains e-liquid, as well as a heating device, which for this device is a heating filament coiled around a portion of a wick.
  • the wick is partially immersed in the e-liquid, and conveys e-liquid from the tank to the heating filament.
  • the device is activated when a microprocessor on board the main body detects a user inhaling through the mouthpiece. When the device is activated, electrical energy is supplied from the power source to the heating device, which heats e-liquid from the tank to produce a vapour which is inhaled by a user through the mouthpiece.
  • a smoking substitute device it is desirable to deliver nicotine into the user’s lungs, where it can be absorbed into the bloodstream.
  • “vaping” approach “e-liquid” is heated by a heating device to produce an aerosol vapour which is inhaled by a user.
  • Many e-cigarettes also deliver flavour to the user, to enhance the experience.
  • Flavour compounds are contained in the e- liquid that is heated. Heating of the flavour compounds may be undesirable as the flavour compounds are inhaled into the user’s lungs.
  • Toxicology restrictions are placed on the amount of flavour that can be contained in the e-liquid. This can result in some e-liquid flavours delivering a weak and underwhelming taste sensation to consumers in the pursuit of safety.
  • an aerosol delivery device comprising a switching device configured to provide relative movement between an aerosol generator and an airflow passage to vary a mass of first aerosol precursor per delivery event.
  • an aerosol delivery device comprising an aerosol generator and a switching device, the aerosol generator comprising: an aerosol generator portion configured to receive an aerosol precursor; and an air flow passage configured to direct air past the aerosol generator portion to pick up the aerosol precursor from the aerosol generator portion to form an aerosol during a delivery event, wherein the switching device is configured to provide relative movement between the aerosol generator portion and the airflow passage to vary a mass of aerosol precursor per delivery event.
  • the switching device may be configured to provide the relative movement to vary a surface area of the aerosol generator portion located in an aerosol generation region of the airflow passage and thereby vary the mass of aerosol precursor per delivery event.
  • the switching device may be configured to provide the relative movement to vary a velocity of airflow past the aerosol generator portion and thereby vary the mass of aerosol precursor per delivery event.
  • the switching device may be configured to slide the aerosol generator portion to provide the relative movement.
  • the aerosol delivery device may comprise a storage for storing the aerosol precursor.
  • the switching device may be further configured to slide the storage with the aerosol generator portion.
  • the switching device may be configured to provide a relative bias between the aerosol generator and the airflow passage towards a position in which the mass of aerosol precursor per delivery event is reduced.
  • the switching device may permit switching between a normal mode and a boost mode, wherein the aerosol generator is configured to: in the normal mode, produce aerosol comprising a first mass of aerosol precursor per delivery event; and in the boost mode, produce aerosol comprising a second mass of aerosol precursor per delivery event, wherein the second mass is greater than the first mass.
  • the switching device may permit switching into an off mode, wherein in the off mode, the aerosol delivery device is configured not to produce aerosol during the delivery event.
  • the switching device may be configured to bias the aerosol generator from the boost mode towards the normal mode.
  • the switching device may permit continuous variation in mass of aerosol precursor per delivery event.
  • the aerosol generator may comprise a member, the member comprising the aerosol generator portion, wherein the member is configured to transfer the aerosol precursor to the aerosol generator portion.
  • the aerosol may comprise a flavour component.
  • the aerosol may be sized to inhibit pulmonary penetration, and the aerosol is transmissible within at least one of a mammalian oral cavity and a mammalian nasal cavity.
  • the aerosol delivery device may be a consumable for a smoking substitute device.
  • the storage may comprise a reservoir, the reservoir formed of a first porous material.
  • the storage may comprise a tank configured to store the first aerosol precursor as a free liquid.
  • the aerosol delivery device may be a consumable for a smoking substitute device.
  • the aerosol delivery device may comprise an additional aerosol generator, the additional aerosol generator configured to produce an additional aerosol from an additional aerosol precursor during the delivery event.
  • the additional aerosol generator may be configured to produce the additional aerosol comprising substantially the same mass of additional aerosol precursor per delivery event independently of the mass of aerosol precursor per delivery event.
  • the additional aerosol generator may be configured to heat the additional aerosol precursor to form the additional aerosol.
  • the second aerosol precursor may comprise an active component.
  • the active component may be nicotine.
  • the additional aerosol may be sized for pulmonary penetration.
  • the present disclosure also relates to an aerosol delivery device which is switchable between: a normal mode in which an aerosol comprising a first mass of aerosol precursor is produced; and a boost mode in which an aerosol comprising a second mass of aerosol precursor is produced, wherein the second mass is greater than the first mass.
  • an aerosol delivery device comprising: an aerosol generator configured to produce an aerosol from an aerosol precursor during a delivery event, wherein the aerosol comprises a flavour component; and a switching device permitting switching of the aerosol generator between a normal mode and a boost mode, wherein the aerosol generator is configured to: in the normal mode, produce aerosol comprising a first mass of aerosol precursor per delivery event; and in the boost mode, produce aerosol comprising a second mass of aerosol precursor per delivery event, wherein the second mass is greater than the first mass.
  • the switching device may further permit switching of the aerosol generator into an off mode, wherein in the off mode, the aerosol generator is configured not to produce aerosol during the delivery event.
  • the switching device may permit continuous variation in mass of aerosol precursor per delivery event between the normal mode and the boost mode.
  • the switching device may be configured to bias the aerosol generator from the boost mode towards the normal mode.
  • the switching device may comprise a sliding switching mechanism slidable to switch the aerosol generator between the normal mode and the boost mode.
  • the aerosol generator may comprise: an aerosol generator portion configured to receive the aerosol precursor; and an air flow passage configured to direct air past the aerosol generator portion to pick up the aerosol precursor from the aerosol generator portion to form the aerosol, wherein the switching device is configured to provide relative movement between the aerosol generator portion and the airflow passage to switch the aerosol generator between the normal mode and the boost mode.
  • the switching device may be configured to provide the relative movement to vary a surface area of the aerosol generator portion located in an aerosol generation region of the airflow passage to switch the aerosol generator between the normal mode and the boost mode.
  • the switching device may be configured to provide the relative movement to vary a velocity of airflow past the aerosol generator portion to switch the aerosol generator between the normal mode and the boost mode.
  • the switching device may be configured to slide the aerosol generator portion to switch the aerosol generator between the normal mode and the boost mode.
  • the aerosol delivery device may comprise a storage for storing the aerosol precursor.
  • the switching device may be further configured to slide the storage with the aerosol generator portion.
  • the switching device may be configured to provide a relative bias between the aerosol generator and the airflow passage towards the normal mode.
  • the aerosol generator may comprise a member, the member comprising the aerosol generator portion, wherein the member is configured to transfer the aerosol precursor to the aerosol generator portion.
  • the aerosol may comprise a flavour component.
  • the aerosol may be sized to inhibit pulmonary penetration, and the aerosol is transmissible within at least one of a mammalian oral cavity and a mammalian nasal cavity.
  • the aerosol delivery device may be a consumable for a smoking substitute device.
  • the storage may comprise a reservoir, the reservoir formed of a first porous material.
  • the storage may comprise a tank configured to store the aerosol precursor as a free liquid.
  • the aerosol delivery device may be a consumable for a smoking substitute device.
  • the aerosol delivery device may comprise an additional aerosol generator, the additional aerosol generator configured to produce an additional aerosol from an additional aerosol precursor during the delivery event.
  • the additional aerosol generator may be configured to produce the additional aerosol comprising substantially the same mass of additional aerosol precursor per delivery event independently of the mass of aerosol precursor per delivery event.
  • the additional aerosol generator may be configured to heat the additional aerosol precursor to form the additional aerosol.
  • the second aerosol precursor may comprise an active component.
  • the active component may be nicotine.
  • the additional aerosol may be sized for pulmonary penetration.
  • the present disclosure also relates to an aerosol delivery device comprising a supporting portion connecting a transfer element to a switch such that movement of the switch causes movement of the transfer element.
  • aerosol delivery device comprising: a storage for storing an aerosol precursor; a transfer element for transferring aerosol precursor from the storage; a switch; and a supporting portion connecting the transfer element to the switch such that movement of the switch causes movement of the transfer element.
  • the transfer element may be for transferring aerosol precursor from the storage to an aerosol generator.
  • the switch may be referred to as an activation mechanism.
  • the supporting portion may have the shape of an incomplete ring or collar, the transfer element being provided within the incomplete ring/collar and held therein through a friction fit.
  • the supporting portion e.g. the ring/collar may be integrally formed with a mouthpiece of the aerosol delivery device.
  • the aerosol delivery device may comprise a barrier arrangement for inhibiting flow of aerosol precursor from the storage, wherein the transfer element is movable with respect to the barrier arrangement to open the barrier arrangement so that the transfer element can transfer aerosol precursor from the storage on movement of the switch.
  • the aerosol delivery device may comprise an aerosol generator comprising an aerosol generator portion configured to receive the aerosol precursor from the transfer element; and an air flow passage configured to direct air past the aerosol generator portion to pick up the aerosol precursor from the aerosol generator portion to form an aerosol.
  • the aerosol delivery device may comprise a member, the member comprising the transfer element and the aerosol generator portion, wherein the member is movable from a first position to a second position to open the barrier arrangement.
  • the member may be slidable from the first position to the second position to open the barrier arrangement.
  • the aerosol delivery device may comprise a mouthpiece and a body, wherein the mouthpiece is slidable relative to the body to provide the switch.
  • the barrier arrangement may be configured to open in response to sliding of the mouthpiece relative to the body.
  • the barrier arrangement may be configured to remain permanently open after opening.
  • the barrier arrangement may comprise a plug received in a tube, the plug configured to inhibit flow of aerosol precursor from the storage to the transfer element, wherein the plug is displaceable from the tube on movement of the transfer element so that the transfer element can transfer aerosol precursor from the storage.
  • the aerosol delivery device may comprise a guide for inhibiting return of the plug to the tube after the plug is displaced from the tube.
  • the barrier arrangement may comprise a deformable barrier component, and the transfer element is configured to deform the barrier component to open the barrier arrangement.
  • the aerosol delivery device may comprise a pressure relief opening in the storage; and a blocking arrangement for inhibiting flow through the pressure relief opening, wherein the blocking arrangement is openable to permit air to flow through the pressure relief opening and into the storage as the storage empties of aerosol precursor.
  • the aerosol delivery device may be a consumable for a vaping device.
  • the aerosol delivery device may comprise an additional aerosol generator, the additional aerosol generator configured to produce an additional aerosol from an additional aerosol precursor.
  • the disclosure includes the combination of the aspects and preferred features described except where such a combination is clearly impermissible or expressly avoided.
  • Fig. 1 shows a schematic drawing of a smoking substitute system
  • Fig. 2 shows a schematic drawing of a smoking substitute system
  • Fig. 3 shows a schematic drawing of a smoking substitute system
  • Fig. 4 shows a schematic drawing of a smoking substitute system
  • Fig. 5 shows a cutaway view of a consumable
  • Fig. 6 shows a cross-sectional view of a flavour pod portion of a consumable
  • Fig. 7a shows a partial cutaway view of a consumable with an aerosol generator portion in a normal mode
  • Fig. 7b shows a partial cutaway view of a consumable with an aerosol generator portion in a boost mode
  • Fig. 8 shows a cross-sectional view of a consumable in a deactivated state
  • Fig. 9 shows a cross-sectional view of the consumable of Fig. 5 in an activated state
  • Fig. 10 a cross-sectional view of a flavour pod portion of a consumable
  • Fig. 11a shows a top view of a flavour pod portion of a consumable
  • Fig. 11 b shows a cut away perspective view of a flavour pod portion of a consumable.
  • a smoking substitute system comprising a smoking substitute device 100.
  • the base unit 100 includes elements such as a battery, an electronic controller, and a pressure transducer.
  • the substitute smoking system comprises a cartomiser 101 and a flavour pod 102.
  • the cartomiser 101 may engage with the smoking substitute device 100 via a push-fit engagement, a screw-thread engagement, or a bayonet fit, for example.
  • a cartomiser may also be referred to as a“pod”.
  • the smoking substitute system may be an aerosol delivery device according to the present disclosure.
  • the flavour pod 102 is configured to engage with the cartomiser 101 and thus with the substitute smoking device 100.
  • the flavour pod 102 may engage with the cartomiser 101 via a push-fit engagement, a screw-thread engagement, or a bayonet fit, for example.
  • Fig. 2 illustrates the cartomiser 101 engaged with the substitute smoking device 100, and the flavour pod 102 engaged with the cartomiser 101 .
  • the cartomiser 101 and the flavour pod 102 are distinct elements.
  • Each of the cartomiser 101 and the flavour pod may be an aerosol delivery device according to the present disclosure.
  • the cartomiser 101 and the flavour pod 102 may alternatively be combined into a single component that implements the functionality of the cartomiser 101 and flavour pod 102.
  • a single component may also be an aerosol delivery device according to the present disclosure.
  • the cartomiser may be absent, with only a flavour pod 102 present.
  • A“consumable” component may mean that the component is intended to be used once until exhausted, and then disposed of as waste or returned to a manufacturer for reprocessing.
  • a smoking substitute system comprising a smoking substitute device 100 and a consumable 103.
  • the consumable 103 combines the functionality of the cartomiser 101 and the flavour pod 102.
  • the consumable 103 and the smoking substitute device 100 are shown separated from one another.
  • the consumable 103 and the smoking substitute device 100 are engaged with each other.
  • FIG. 5 there is shown a consumable 103 engaged (in Figure 5) or engageable ( Figure 8) with a smoking substitute device 100 via a push-fit engagement.
  • the consumable 103 may be considered to have two portions - a cartomiser portion 104 and a flavour pod portion 105, both of which are located within a single component (as in Figures 3 and 4).
  • the consumable 103 includes an upstream airflow inlet 106 and a downstream airflow outlet 107. In other examples a plurality of inlets and/or outlets are included. Between and fluidly connecting the inlet 106 and the outlet 107 there is an airflow passage 108. The outlet 107 is located at the mouthpiece 109 of the consumable 103, and is formed by a mouthpiece aperture.
  • the consumable 103 includes a flavour pod portion 105.
  • the flavour pod portion 105 is configured to generate a first (flavour) aerosol for output from the outlet 107 of the mouthpiece 109 of the consumable 103.
  • the flavour pod portion 105 of the consumable 103 includes a liquid transfer element int eh form of a member 1 15.
  • the member 1 15 acts as a passive aerosol generator (i.e. an aerosol generator which does not use heat to form the aerosol, also referred to as an“aerosol generator” and a “first aerosol generator”), and is formed of a porous material.
  • the member 1 15 comprises a supporting portion 1 17, which is located inside a housing, and an aerosol generator portion 1 18, which is located in the airflow passage 108.
  • the aerosol generator portion 1 18 is a porous nib.
  • a first storage 1 16 (in this example a tank) for storing an aerosol precursor (i.e.“first aerosol precursor”, which is a flavour liquid) is fluidly connected to the member 1 15.
  • first aerosol precursor i.e.“first aerosol precursor”, which is a flavour liquid
  • the porous nature of the member 1 15 means that flavour liquid from the first storage 1 16 is drawn into the member 1 15.
  • further flavour liquid is drawn from the first storage 1 16 into the member 1 15 via a wicking action.
  • the barrier arrangement 120 Before activation, the barrier arrangement 120 (see Figure 8) is closed and inhibits evaporation of aerosol precursor. In this example, this is achieved by the barrier arrangement inhibiting flow of aerosol precursor from the first storage 1 16 to the member 1 15. In order to inhibit flow of aerosol precursor, the barrier arrangement 120 substantially isolates the first storage 1 16 from the member 1 15.
  • the barrier arrangement comprises a plug 120 (preferably formed from silicon) located at one end of a tube 122 containing the member 1 15 close to the first storage 1 16.
  • the plug may be replaced by a deformable and/or breakable barrier component, e.g. any one of: a duck bill valve; a split valve or diaphragm; or a sheet of foil, which may be pierced by the member 1 15 when opening the barrier arrangement.
  • the first storage 1 16 further includes a pressure relief opening 132, which in the deactivated state is sealed by blocking arrangement.
  • the blocking arrangement comprises a pierceable cover (preferably made from foil).
  • Piercing member 130 which is formed as a part of the mouthpiece 109 and may take the form of a blade, pierces the pierceable cover and opens the pressure relief opening 132 when the consumable is moved to the activated state (as is discussed in more detail below). This means that opening of the barrier arrangement also effects opening of the blocking arrangement.
  • the aerosol generator portion 1 18 is located within the airflow passage 108 through the consumable 103.
  • the aerosol generator portion 1 18 therefore constricts or narrows the airflow passage 108.
  • the aerosol generator portion 1 18 occupies some of the area of the airflow passage, resulting in constriction of the airflow passage 108.
  • the airflow passage 108 is narrowest adjacent to the aerosol generator portion 1 18. Since the constriction results in increased air velocity and corresponding reduction in air pressure at the aerosol generator portion 1 18, the constriction is a Venturi aperture 1 19.
  • the constriction is generally toroidal in shape, and may include one or more intersections where supports contact the aerosol generator portion 1 18.
  • the cartomiser portion 104 of the consumable 103 includes a second storage 1 10 (in this example a tank) for storing a second aerosol precursor (i.e. e-liquid, which may contain nicotine). Extending into the second storage 1 10 is a wick 1 1 1 .
  • the wick 1 1 1 is formed from a porous wicking material (e.g. a polymer) that draws second aerosol precursor from the second storage 1 10 into a central region of the wick 1 1 1 that is located outside the e-liquid storage tank 1 10.
  • a heater 1 12 is a configured to heat the central region of the wick 1 1 1 .
  • the heater 1 12 includes a resistive heating filament that is coiled around the central region of the wick 1 1 1 .
  • the wick 1 1 1 , the heater 1 12 and the e-liquid storage tank 1 10 together act as an active aerosol generator (i.e. an aerosol generator which uses heat to form the aerosol, also referred to as an“additional aerosol generator” and a “second aerosol generator”).
  • the first and second aerosol generators are both at least partially located within the airflow passage 108, with the first aerosol generator downstream (with respect to air flow in use) of the second aerosol generator.
  • the consumable 103 may be supplied with electrical power for activation of the heater 1 12, the consumable 103 includes a pair of consumable electrical contacts 1 13.
  • the consumable electrical contacts 1 13 are configured for electrical connection to a corresponding pair of electrical supply contacts 1 14 in the smoking substitute device 100.
  • the consumable electrical contacts 1 13 are electrically connected to the electrical supply contacts 1 14 when the consumable 103 is engaged with the smoking substitute device 100.
  • the smoking substitute device 100 includes an electrical power source (not shown), for example a battery.
  • Figure 9 shows the consumable 103 of Figure 8 in an activated state, like features are indicated by like reference numerals.
  • mouthpiece 109 is moved along a central axis 150 towards cartomizer portion 104 (e.g. one along which the consumable extends, and along which member 1 15 extends). Moving the mouthpiece 109 in this way effects relative movement between the liquid transfer element (i.e. the member 1 15) and the barrier arrangement. This causes the barrier arrangement to open.
  • an activation switch is provided on an outer portion of the consumable for opening the barrier arrangement.
  • the mouthpiece 109, via supporting portion 1 17, is fixed to the member 1 15 and therefore member 1 15 moves with the mouthpiece 109.
  • the mouthpiece 109, and member 1 15, is moved relative to the tank 1 16. This causes displacement of the plug 120 and opening of the barrier arrangement 1 16.
  • the supporting portion 1 17 may be integrally formed with the mouthpiece 109. This helps facilitate assembly and also provides better concentricity with the member 1 15.
  • the plug 120 is unconstrained within the first storage.
  • the plug 120 may be received by a guide for inhibiting return of the plug to the closed position after displacement of the plug.
  • the guide may comprise a recess for receiving the plug 120.
  • the barrier arrangement remains permanently open after opening, as the plug 120 does not return to the tube 122.
  • the barrier arrangement is selectively openable and closable by the user. This may be achieved by the plug (or another type of barrier arrangement) being fixed to an end portion of the member 1 15, such that the member 1 15 is selectively exposable to the first storage 1 16.
  • a user draws (or“sucks”, or“pulls”) on the mouthpiece 109 of the consumable 103, which causes a drop in air pressure at the outlet 107, thereby generating air flow through the inlet 106, along the airflow passage 108, out of the outlet 107 and into the user’s mouth.
  • the heater 1 12 When the heater 1 12 is activated (by passing an electric current through the heating filament in response to the user drawing on the mouthpiece 109) the e-liquid located in the wick 1 1 1 adjacent to the heating filament is heated and vaporised to form a vapour.
  • the vapour condenses to form the second aerosol within the airflow passage 108. Accordingly, the second aerosol is entrained in an airflow along the airflow flow passage 108 to the outlet 107 and ultimately out from the mouthpiece 109 for inhalation by the user when the user 10 draws on the mouthpiece 109.
  • the substitute smoking device 100 supplies electrical current to the consumable electrical contacts 1 13. This causes an electric current flow through the heating filament of the heater 1 12 and the heating filament heats up. As described, the heating of the heating filament causes vaporisation of the e-liquid in the wick 1 1 1 to form the second aerosol.
  • the airflow passage 108 As the air flows up through the airflow passage 108, it encounters the aerosol generator portion 1 18.
  • the constriction of the airflow passage 108 caused by the aerosol generator portion 1 18 results in an increase in air velocity and corresponding decrease in air pressure in the airflow in the vicinity of the porous surface 1 18 of the aerosol generator portion 1 15.
  • the corresponding low pressure region causes the generation of the first (flavour) aerosol from the porous surface 1 18 of the aerosol generator portion 1 18.
  • the first (flavour) aerosol is entrained into the airflow and ultimately is output from the outlet 107 of the consumable 103 and thus from the mouthpiece 109 into the user’s mouth.
  • the first aerosol is sized to inhibit pulmonary penetration.
  • the first aerosol is formed of particles with a mass median aerodynamic diameter that is greater than or equal to 15 microns, in particular, greater than 30 microns, more particularly greater than 50 microns, yet more particularly greater than 60 microns, and even more particularly greater than 70 microns.
  • the first aerosol is sized for transmission within at least one of a mammalian oral cavity and a mammalian nasal cavity.
  • the first aerosol is formed by particles having a maximum mass median aerodynamic diameter that is less than 300 microns, in particular less than 200 microns, yet more particularly less than 100 microns. Such a range of mass median aerodynamic diameter will produce aerosols which are sufficiently small to be entrained in an airflow caused by a user drawing air through the flavour element and to enter and extend through the oral and or nasal cavity to activate the taste and/or olfactory receptors.
  • the second aerosol generated is sized for pulmonary penetration (i.e. to deliver an active ingredient such as nicotine to the user’s lungs).
  • the second aerosol is formed of particles having a mass median aerodynamic diameter of less than or equal to 10 microns, preferably less than 8 microns, more preferably less than 5 microns, yet more preferably less than 1 micron.
  • Such sized aerosols tend to penetrate into a human user’s pulmonary system, with smaller aerosols generally penetrating the lungs more easily.
  • the second aerosol may also be referred to as a vapour.
  • the size of aerosol formed without heating is typically smaller than that formed by condensation of a vapour.
  • the mass median aerodynamic diameter is a statistical measurement of the size of the particles/droplets in an aerosol. That is, the mass median aerodynamic diameter quantifies the size of the droplets that together form the aerosol.
  • the mass median aerodynamic diameter may be defined as the diameter at which 50% of the particles/droplets by mass in the aerosol are larger than the mass median aerodynamic diameter and 50% of the particles/droplets by mass in the aerosol are smaller than the mass median aerodynamic diameter.
  • size of the aerosol refers to the size of the particles/droplets that are comprised in the particular aerosol.
  • a flavour pod portion 202 of a consumable the consumable providing an aerosol delivery device.
  • the consumable further comprises a cartomiser portion (not shown in Fig. 6/10) having all of the features of the cartomiser portion 104 described above with respect to Fig.
  • the consumable does not comprise the cartomiser portion, and provides only flavour to the user.
  • the flavour pod portion 202 comprises an aerosol generator (also referred to as a“first aerosol generator”), which comprises an upstream (i.e. upstream with respect to flow of air in use) inlet 204 and a downstream (i.e. downstream with respect to flow of air in use) outlet 206. Between and fluidly connecting the inlet 204 and the outlet 206 the flavour pod portion 204 comprises an airflow passage 208.
  • the airflow passage 208 comprises a first airflow branch 210 and a second airflow branch 212, each of the first airflow branch 210 and the second airflow branch 212 fluidly interconnecting the inlet 204 and the outlet 206.
  • the airflow passage 208 may have an annular shape.
  • the outlet 206 is located at the mouthpiece 209 of the consumable 103, and is also referred to as a mouthpiece aperture 206.
  • the flavour pod portion 202 comprises a storage 214, which stores a first aerosol precursor (also referred to as an“aerosol precursor”.
  • the storage 214 comprises a reservoir 216 located within a chamber 218.
  • the reservoir 216 is formed of a first porous material.
  • the aerosol generator comprises a member 220, which comprises an aerosol generator portion 222 and a supporting portion 223.
  • the aerosol generator portion 222 is located at a downstream end (an upper end in Fig. 6) of the member 220, while the supporting portion 223 makes up the rest of the member 220.
  • the supporting portion 223 is elongate and substantially cylindrical.
  • the aerosol generator portion 222 is bulb-shaped, and comprises a portion which is wider than the supporting portion 223.
  • the aerosol generator portion 222 tapers to a tip at a downstream end of the aerosol generator portion 222.
  • the member 220 extends into and through the storage 214.
  • the member 220 is in contact with the reservoir 216. More specifically, the supporting portion 223 extends into and through the storage 204 and is in contact with the reservoir 216.
  • the member 220 is located in a substantially central position within the reservoir 216 and is substantially parallel to a central axis of the consumable.
  • the member 220 is formed of a second porous material.
  • the first and second airflow branches 210, 212 are located on opposite sides of the member 220.
  • first and second airflow branches 210, 212 are located on opposite sides of the reservoir 216.
  • the first and second airflow branches 210, 212 branch in a radial outward direction (with respect to the central axis of the consumable 200) downstream of the inlet 204 to reach the opposite sides of the reservoir 216.
  • the aerosol generator portion 222 is located in the airflow passage 208 downstream of the first and second airflow branches 210, 212.
  • the first and second airflow branches 210, 212 turn in a radially inward direction to merge at the member 220, at a point upstream of the aerosol generator portion 222.
  • the aerosol generator portion 222 is located in a narrowing section 224 of the airflow passage 208.
  • the narrowing section 224 is downstream of the point at which the first and second airflow branches 210 212 merge, but upstream of the mouthpiece aperture 207.
  • the mouthpiece aperture 207 flares outwardly in the downstream direction, such that a width of the mouthpiece aperture 207 increases in the downstream direction.
  • Air (comprising the second aerosol from the cartomiser portion as explained above with respect to Fig. 5) flows through the inlet 204 before the air flow splits to flow through the first and second airflow branches 210, 212. Further downstream, the first and second airflow branches 210, 212 provide inward airflow towards the member 220 and the aerosol generator portion 222.
  • the velocity of the air increases, resulting in a drop in air pressure.
  • the first aerosol has the particle size and other properties described above with respect to Fig. 5.
  • the member 220 transfers further first aerosol precursor from the storage 214 to the aerosol generator portion 222. More specifically, the member 220 wicks the first aerosol precursor from the storage 214 to the aerosol generator portion 223.
  • the storage 214 comprises a tank containing the first aerosol precursor as free liquid, rather than the reservoir 216 and the chamber 218.
  • the member 220 still extends into the tank to transfer first aerosol precursor from the tank to the aerosol generator portion 223.
  • a third consumable 300 comprises a flavour pod portion 302 and a cartomiser portion 304.
  • the third consumable 300 comprises all of the features of the second consumable (and may also comprise all of the variations of the second consumable 200 described above), and only the differences are described here. For clarity many of the reference numerals are omitted from Fig. 7a and 7b.
  • the flavour pod portion 302 further comprises a switching device 306.
  • the switching device 306 comprises a button 308 and a switching mechanism (not shown).
  • the flavour pod portion 302 comprises a recess 309 for receiving the button 308.
  • the button 308 is located on an in use front face of the third consumable 300.
  • the button 308 is slidable within the recess 309 upwardly and downwardly (i.e. in a downstream direction towards and an upstream direction away from the mouthpiece 209).
  • the button may be slidable in a horizontal plane or may be a rotary switch. These options may help to prevent accidental removal of the third consumable 300.
  • the switching mechanism connects the button 308 to the storage 214 and the member 222.
  • the switching device 306 further comprises a bias device, which is a spring 310.
  • the spring 310 is connected to the storage 214 and an underside of the mouthpiece 209.
  • the spring 310 is configured to push the storage 214 (and hence the member 222) away from the mouthpiece 209.
  • the third consumable 300 comprises an aerosol generator, which comprises all of the features of the first aerosol generator described above.
  • Fig. 7a shows the aerosol generator portion 223 of the aerosol generator in a normal mode
  • Fig. 7b shows the aerosol generator portion 223 in a boost mode.
  • a larger area of the aerosol generator portion 223 is located in an aerosol generation region of the air flow passage 208 than is the case in the normal mode.
  • the aerosol generation region of the air flow passage 208 may be defined as a region in which the velocity of air flow is sufficiently high to generate the first aerosol in use.
  • the aerosol generation region of the air flow passage 208 is the narrowing section 224.
  • the aerosol generator portion 223 provides an increased area of constriction in the narrowing section 224 than is the case in the normal mode, which increases the velocity of airflow past the aerosol generator portion 223 in use compared to the normal mode.
  • the button 308 therefore allows the user to provide relative movement between the aerosol generator portion 223 and the airflow passage 208. This allows the user to vary/adjust a mass flow of aerosol precursor produced per delivery event (i.e. per puff taken by the user).
  • the normal mode is the position in which the surface area of aerosol generator portion 223 located in the aerosol generation region is at a minimum. Additionally, the normal mode is the position in which the constriction in the narrowing section 224 is at a minimum.
  • the boost mode is the position in which the surface area of aerosol generator portion 223 located in the aerosol generation region is at a maximum. Additionally, the boost mode is the position in which the constriction in the narrowing section 224 is at a maximum.
  • the user slides the button 308 in an upward direction (i.e. in a downstream direction and towards the mouthpiece).
  • This effects relative movement between the aerosol generator portion 223 and the airflow passage 208. More specifically, this effects sliding of the storage 214 and the member 222.
  • the button slides in the upward direction, the aerosol generator portion 223 slides further into the narrowing section 224 until the boost mode position is reached.
  • the user may slide the button 308 to any extent between the normal mode and the boost mode, permitting continuous variation in position of the aerosol generation portion 223 and continuous variation in mass of first aerosol precursor per delivery event between the normal mode and the boost mode.
  • the surface area of the aerosol generator portion 223 in the aerosol generation region in this case the narrowing section 224.
  • the aerosol generator portion 223 increases the area of constriction in the narrowing section 224, thereby increasing the velocity of airflow past the aerosol generator portion 223.
  • the aerosol generator In each of the normal mode and the boost mode (and any position of the aerosol generation portion 223 between the normal mode and the boost mode), the aerosol generator generally operates in the same way as the aerosol generator described above with respect to Fig. 6, with air flowing past the aerosol generator portion 223 to pick up aerosol precursor to generate aerosol during a delivery event when a user inhales.
  • the aerosol generator in the normal mode, produces an aerosol comprises a first mass of aerosol precursor per delivery event.
  • the first mass is less than 10 mg. More specifically, the first mass is less than 8 mg. More specifically, the first mass is less than 6 mg.
  • the first mass is at least 2 mg. More specifically, the first mass is at least 3 mg. More specifically, the first mass is at least 4 mg. More specifically, the first mass is substantially 5 mg.
  • the aerosol generator produces an aerosol which comprises a second mass of aerosol precursor per delivery event. The second mass is greater than the first mass. The second mass is at least 10 mg. More specifically, the second mass is at least 12 mg. More specifically, the second mass is at least 14 mg.
  • the second mass is not more than 20 mg. More specifically, the second mass is not more than 18 mg. More specifically, the second mass is not more than 16 mg. More specifically, the second mass is substantially 15 mg.
  • the second aerosol generator (or“additional aerosol generator”) of the cartomiser portion continues to produce second aerosol (or“additional aerosol”) comprising substantially the same mass of second aerosol precursor (or“additional aerosol precursor”) per delivery event regardless of the mode of the aerosol generator and the position of the aerosol generator portion 223.
  • the switching device permits the aerosol generator portion 223 to be moved beyond the normal mode, to a position in which in the aerosol generator portion 223 has substantially zero surface area in the generation region. In this position, substantially zero aerosol precursor is produced during the delivery event, thereby providing an off mode.
  • Figs. 1 1 a and 1 1 b show further views of the flavour pod portion 202 which highlight features of the mouthpiece 209. Many of the reference numerals of Fig. 10 are omitted from Fig. 1 1 a and 1 1 b for clarity.
  • the mouthpiece aperture 206 comprises an inner surface 226, which is uneven.
  • the inner surface 226 has the form of a substantially frustoconical surface, but includes grooves or channels 228 to make the inner surface 226 somewhat uneven.
  • the inner surface 226 may have another form (for example, the form a substantially cylindrical surface), and may include any type of protrusion or groove to make the inner surface uneven.
  • the inner surface 226 is angled with respect to an axial direction (i.e. relative to a central axis extending from a base of the consumable to the mouthpiece) such that the width of the mouthpiece aperture 209 increases in the downstream direction.
  • the inner surface 226 is immediately downstream of the narrowing section 224 of the airflow passage 108.
  • the grooves 228 are generally v-shaped in cross-sectional profile, and extend in the axial direction for the full length of the inner surface 226.
  • Each groove 228 is formed from a pair of surfaces angled at between 30 and 90 degrees relative to each other. More specifically, each groove 228 is formed from a pair of surfaces angled at 60 degrees relative to each other.
  • the grooves 228 have a depth (measured normal to the inner surface 226) of at least 0.2 mm. More specifically, the grooves 228 have a depth of at least 0.3 mm. More specifically, the grooves 228 have a depth of at least 0.4 mm.
  • the grooves 228 have a depth of less than 0.8 mm. More specifically, the grooves have a depth of less than 0.7 mm. More specifically, the grooves have a depth of less than 0.6 mm.
  • the grooves have a depth of substantially 0.5 mm.
  • the grooves 228 are substantially equi-spaced in a circumferential manner around the inner surface 226.
  • the inner surface 226 comprises at least 6 grooves. More specifically, the inner surface comprises at least 7 grooves. More specifically, the inner surface 226 comprises at least 8 grooves.
  • the inner surface 226 comprises at most 12 grooves 228. More specifically, the inner surface 226 comprises at most 1 1 grooves 228. More specifically, the inner surface 226 comprises at most 10 grooves 228.
  • the inner surface 226 comprises 9 grooves 228.
  • the grooves 228 are spaced apart from each other by substantially 1 mm at the downstream end of the inner surface 226.
  • the spacing at the downstream end of grooves or protrusions may be selected such that it is equal to or less than the mass median diameter (as described above) of particles in the first aerosol.
  • the inner surface 226 comprises a smooth polished surface between the grooves 228. Polishing the surface in this way provides improved aerodynamic properties. However, in other examples, the inner surface 226 may be textured. In such examples, the texture of the surface may provide the uneven surface, and no grooves are required,
  • the uneven nature of the inner surface 226 makes it easier for droplets to form on the inner surface 226, preventing large droplets from entering the user’s mouth.
  • the grooves 228 help to channel the large droplets back into the consumable.
  • An aerosol delivery device comprising:
  • an aerosol generator configured to produce an aerosol from an aerosol precursor during a delivery event, wherein the aerosol comprises a flavour component
  • a switching device permitting switching of the aerosol generator between a normal mode and a boost mode, wherein the aerosol generator is configured to:
  • aerosol generator comprises:
  • an aerosol generator portion configured to receive the aerosol precursor
  • an air flow passage configured to direct air past the aerosol generator portion to pick up the aerosol precursor from the aerosol generator portion to form the aerosol
  • switching device is configured to provide relative movement between the aerosol generator portion and the airflow passage to switch the aerosol generator between the normal mode and the boost mode.
  • An aerosol delivery device according to any one paragraphs 6 to 8, wherein the switching device is configured to slide the aerosol generator portion to switch the aerosol generator between the normal mode and the boost mode.
  • the aerosol delivery device comprises a storage for storing the aerosol precursor, wherein the switching device is further configured to slide the storage with the aerosol generator portion.
  • the aerosol generator comprises a member, the member comprising the aerosol generator portion, wherein the member is configured to transfer the aerosol precursor to the aerosol generator portion.
  • An aerosol delivery device configured to produce an additional aerosol from an additional aerosol precursor during the delivery event.
  • the additional aerosol generator is configured to produce the additional aerosol comprising substantially the same mass of additional aerosol precursor per delivery event in the normal mode and in the boost mode.
  • An aerosol delivery device comprising:
  • a transfer element for transferring aerosol precursor from the storage
  • An aerosol delivery device according to paragraph 16, and further comprising a barrier arrangement for inhibiting flow of aerosol precursor from the storage, wherein the transfer element is movable with respect to the barrier arrangement to open the barrier arrangement so that the transfer element can transfer aerosol precursor from the storage on movement of the switch.
  • an aerosol generator comprising an aerosol generator portion configured to receive the aerosol precursor from the transfer element
  • an air flow passage configured to direct air past the aerosol generator portion to pick up the aerosol precursor from the aerosol generator portion to form an aerosol.
  • An aerosol delivery device according to paragraph 18 and further comprising a member, the member comprising the transfer element and the aerosol generator portion, wherein the member is movable from a first position to a second position to open the barrier arrangement.
  • An aerosol delivery device according to any one of paragraphs 16 to 20, and further comprising a mouthpiece and a body, wherein the mouthpiece is slidable relative to the body to provide the switch.
  • An aerosol delivery device according to any one of paragraphs 16 to 24, wherein the barrier arrangement comprises a plug received in a tube, the plug configured to inhibit flow of aerosol precursor from the storage to the transfer element,
  • plug is displaceable from the tube on movement of the transfer element so that the transfer element can transfer aerosol precursor from the storage.
  • An aerosol delivery device according to paragraph 25, and further comprising a guide for inhibiting return of the plug to the tube after the plug is displaced from the tube.
  • An aerosol delivery device according to any one of paragraphs 16 to 23, wherein the barrier arrangement comprises a deformable barrier component, and the transfer element is configured to deform the barrier component to open the barrier arrangement.
  • An aerosol delivery device according to any one of paragraphs 16 to 27, and further comprising: a pressure relief opening in the storage; and
  • blocking arrangement is openable to permit air to flow through the pressure relief opening and into the storage as the storage empties of aerosol precursor.
  • An aerosol delivery device according to any one of paragraphs 16 to 28, wherein the aerosol delivery device is a consumable for a vaping device.
  • An aerosol delivery device according to any one of paragraphs 16 to 29 and further comprising an additional aerosol generator, the additional aerosol generator configured to produce an additional aerosol from an additional aerosol precursor.

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  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Abstract

La présente invention concerne un dispositif de distribution d'aérosol comprenant un générateur d'aérosol et un dispositif de commutation, le générateur d'aérosol comprenant : une partie de génération d'aérosol conçue pour recevoir un précurseur d'aérosol ; et un passage d'écoulement d'air conçu pour diriger l'air au-delà de la partie de génération d'aérosol pour prélever le précurseur d'aérosol à partir de la partie de génération d'aérosol pour former un aérosol pendant un événement de distribution, le dispositif de commutation étant conçu pour fournir un mouvement relatif entre la partie de génération d'aérosol et le passage d'écoulement d'air pour faire varier une masse de précurseur d'aérosol par événement de distribution
PCT/EP2020/064318 2019-05-24 2020-05-22 Dispositif de distribution d'aérosol WO2020239635A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP20727294.9A EP3975772A1 (fr) 2019-05-24 2020-05-22 Dispositif de distribution d'aérosol
US17/533,736 US20220079233A1 (en) 2019-05-24 2021-11-23 Aerosol delivery device

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP19176368.9A EP3741411A1 (fr) 2019-05-24 2019-05-24 Dispositif de distribution d'aérosols
EP19176412.5A EP3741410A1 (fr) 2019-05-24 2019-05-24 Dispositif de distribution d'aérosol
EP19176388.7A EP3741230A1 (fr) 2019-05-24 2019-05-24 Dispositif de distribution d'aérosol
EP19176388.7 2019-05-24
EP19176368.9 2019-05-24
EP19176412.5 2019-05-24

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PCT/EP2020/064323 Continuation WO2020239639A1 (fr) 2019-05-24 2020-05-22 Dispositif de distribution d'aérosol

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WO2020239635A1 true WO2020239635A1 (fr) 2020-12-03

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WO2022148833A1 (fr) * 2021-01-07 2022-07-14 Jt International S.A. Ensemble de distribution de vapeur et ensemble de génération d'aérosol associé
WO2023114340A1 (fr) * 2021-12-14 2023-06-22 Alexza Pharmaceuticals, Inc. Dispositif médical portable à administration améliorée de particules d'aérosol

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WO2013093469A2 (fr) * 2011-12-20 2013-06-27 British American Tobacco (Investments) Limited Articles à fumer, et autres articles émetteurs de flux
WO2017068101A1 (fr) * 2015-10-22 2017-04-27 Philip Morris Products S.A. Article de génération d'aérosol, système de génération d'aérosol et procédé de fabrication d'un article de génération d'aérosol
US20180027876A1 (en) * 2016-07-28 2018-02-01 Rai Strategic Holdings, Inc. Aerosol delivery devices including a selector and related methods
EP3298914A1 (fr) * 2016-09-26 2018-03-28 Shenzhen First Union Technology Co., Ltd. Cigarette électronique
GB2566766A (en) * 2017-09-22 2019-03-27 Nerudia Ltd Device, system and method

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US20080241255A1 (en) * 2007-03-30 2008-10-02 Duke University Device and method for delivery of a medicament
WO2013093469A2 (fr) * 2011-12-20 2013-06-27 British American Tobacco (Investments) Limited Articles à fumer, et autres articles émetteurs de flux
WO2017068101A1 (fr) * 2015-10-22 2017-04-27 Philip Morris Products S.A. Article de génération d'aérosol, système de génération d'aérosol et procédé de fabrication d'un article de génération d'aérosol
US20180027876A1 (en) * 2016-07-28 2018-02-01 Rai Strategic Holdings, Inc. Aerosol delivery devices including a selector and related methods
EP3298914A1 (fr) * 2016-09-26 2018-03-28 Shenzhen First Union Technology Co., Ltd. Cigarette électronique
GB2566766A (en) * 2017-09-22 2019-03-27 Nerudia Ltd Device, system and method

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WO2022148833A1 (fr) * 2021-01-07 2022-07-14 Jt International S.A. Ensemble de distribution de vapeur et ensemble de génération d'aérosol associé
WO2023114340A1 (fr) * 2021-12-14 2023-06-22 Alexza Pharmaceuticals, Inc. Dispositif médical portable à administration améliorée de particules d'aérosol

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