WO2020204373A3 - Apparatus for diagnosing solid cancers and method for providing information on solid cancer diagnosis - Google Patents

Apparatus for diagnosing solid cancers and method for providing information on solid cancer diagnosis Download PDF

Info

Publication number
WO2020204373A3
WO2020204373A3 PCT/KR2020/003158 KR2020003158W WO2020204373A3 WO 2020204373 A3 WO2020204373 A3 WO 2020204373A3 KR 2020003158 W KR2020003158 W KR 2020003158W WO 2020204373 A3 WO2020204373 A3 WO 2020204373A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer
solid
diagnosing
providing information
cancer diagnosis
Prior art date
Application number
PCT/KR2020/003158
Other languages
French (fr)
Korean (ko)
Other versions
WO2020204373A2 (en
Inventor
유병철
김경희
박상재
우상명
이영주
이준화
최범규
Original Assignee
국립암센터
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020200024845A external-priority patent/KR102395558B1/en
Application filed by 국립암센터 filed Critical 국립암센터
Priority to JP2021572576A priority Critical patent/JP7401121B2/en
Priority to US17/615,506 priority patent/US20220349895A1/en
Priority to EP20782471.5A priority patent/EP4027139A4/en
Priority to CN202080040771.7A priority patent/CN113939737A/en
Publication of WO2020204373A2 publication Critical patent/WO2020204373A2/en
Publication of WO2020204373A3 publication Critical patent/WO2020204373A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57415—Specifically defined cancers of breast
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57419—Specifically defined cancers of colon
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57446—Specifically defined cancers of stomach or intestine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8818—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8822—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G01N2405/04—Phospholipids, i.e. phosphoglycerides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention relates to an apparatus for diagnosing solid cancers comprising lung cancer, pancreatic cancer, bile duct cancer, colorectal cancer, breast cancer, gastric cancer, brain tumors, kidney cancer, liver cancer, and cervical cancer. More specifically, the apparatus comprises: a concentration measurement unit for measuring the concentration of each of acyl-carnitine (AC), nudifloramide (2PY), and lysophosphatidylcholine (LPC) from a biological sample; a pre-processing unit for pre-processing the measured concentrations; and a diagnosis unit for determining the diagnosis information of cancer through linear discriminant analysis using the pre-processed concentrations.
PCT/KR2020/003158 2019-04-01 2020-03-06 Apparatus for diagnosing solid cancers and method for providing information on solid cancer diagnosis WO2020204373A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2021572576A JP7401121B2 (en) 2019-04-01 2020-03-06 Solid cancer diagnostic device and method for providing solid cancer diagnostic information
US17/615,506 US20220349895A1 (en) 2019-04-01 2020-03-06 Apparatus for diagnosing solid cancers and method for providing information on solid cancer diagnosis
EP20782471.5A EP4027139A4 (en) 2019-04-01 2020-03-06 Apparatus for diagnosing solid cancers and method for providing information on solid cancer diagnosis
CN202080040771.7A CN113939737A (en) 2019-04-01 2020-03-06 Solid cancer diagnosis device and method for providing solid cancer diagnosis information

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2019-0037756 2019-04-01
KR20190037756 2019-04-01
KR10-2020-0024845 2020-02-28
KR1020200024845A KR102395558B1 (en) 2019-04-01 2020-02-28 Device for diagnosing solid tumors and Method for providing information on diagnosing solid tumors

Publications (2)

Publication Number Publication Date
WO2020204373A2 WO2020204373A2 (en) 2020-10-08
WO2020204373A3 true WO2020204373A3 (en) 2020-11-19

Family

ID=72666403

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2020/003158 WO2020204373A2 (en) 2019-04-01 2020-03-06 Apparatus for diagnosing solid cancers and method for providing information on solid cancer diagnosis

Country Status (6)

Country Link
US (1) US20220349895A1 (en)
EP (1) EP4027139A4 (en)
JP (1) JP7401121B2 (en)
KR (1) KR20220062238A (en)
CN (1) CN113939737A (en)
WO (1) WO2020204373A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101462206B1 (en) * 2013-06-26 2014-11-20 한국과학기술연구원 Method for providing basic information for diagnosing stomach cancer using the change of tryptophan metabolism
KR20150021651A (en) * 2013-08-21 2015-03-03 이화여자대학교 산학협력단 Composition comprising lysophosphatidylcholine and homocysteic acid for ovarian cancer diagnosis and method using the same
US20150065366A1 (en) * 2011-11-11 2015-03-05 Metabolon, Inc. Biomarkers for Bladder Cancer and Methods Using the Same
KR20180035062A (en) * 2016-09-28 2018-04-05 국립암센터 Device for diagnosing colorectal cancer and Method for providing information on diagnosing colorectal cancer
KR20180064164A (en) * 2016-12-05 2018-06-14 한국과학기술연구원 Kit for diagnosis of coronary heart disease using multi-metabolites and clinical parameters, and method for providing information for diagnosis of coronary heart disease using the same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006044680A1 (en) 2004-10-14 2006-04-27 The Cleveland Clinic Foundation Methods of detecting colorectal cancer
JP5696152B2 (en) 2009-10-01 2015-04-08 フェノメノーム ディスカバリーズ インク Serum-based biomarkers of pancreatic cancer and their use for disease detection and diagnosis
EP2788763A4 (en) 2011-12-09 2015-10-07 Metabolon Inc Biomarkers for kidney cancer and methods using the same
KR101461615B1 (en) 2012-01-03 2015-04-22 국립암센터 Apparatus for diagnosis cancer
CN102680597B (en) 2012-05-08 2014-09-24 北京师范大学 Kit for distinguishing colorectal adenomas from colorectal cancer
JP6195147B2 (en) * 2013-03-18 2017-09-13 学校法人自治医科大学 Isocitrate dehydrogenase mutation detection marker
AU2015314220A1 (en) 2014-09-10 2017-04-20 Biocrates Life Sciences Ag Biomarkers for assessing breast cancer
KR101835979B1 (en) 2016-06-13 2018-03-08 국립암센터 Method for providing information on diagnosing biliary tract cancer and device for diagnosing biliary tract cancer
US20180024132A1 (en) * 2016-07-07 2018-01-25 Berg Llc Lipid, protein, and metabolite markers for the diagnosis and treatment of prostate cancer
CN109239210B (en) 2018-09-10 2019-11-19 哈尔滨工业大学 A kind of ductal adenocarcinoma of pancreas marker and its screening technique

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150065366A1 (en) * 2011-11-11 2015-03-05 Metabolon, Inc. Biomarkers for Bladder Cancer and Methods Using the Same
KR101462206B1 (en) * 2013-06-26 2014-11-20 한국과학기술연구원 Method for providing basic information for diagnosing stomach cancer using the change of tryptophan metabolism
KR20150021651A (en) * 2013-08-21 2015-03-03 이화여자대학교 산학협력단 Composition comprising lysophosphatidylcholine and homocysteic acid for ovarian cancer diagnosis and method using the same
KR20180035062A (en) * 2016-09-28 2018-04-05 국립암센터 Device for diagnosing colorectal cancer and Method for providing information on diagnosing colorectal cancer
KR20180064164A (en) * 2016-12-05 2018-06-14 한국과학기술연구원 Kit for diagnosis of coronary heart disease using multi-metabolites and clinical parameters, and method for providing information for diagnosis of coronary heart disease using the same

Also Published As

Publication number Publication date
CN113939737A (en) 2022-01-14
KR20220062238A (en) 2022-05-16
EP4027139A2 (en) 2022-07-13
JP7401121B2 (en) 2023-12-19
WO2020204373A2 (en) 2020-10-08
EP4027139A4 (en) 2023-12-06
JP2022531621A (en) 2022-07-07
US20220349895A1 (en) 2022-11-03

Similar Documents

Publication Publication Date Title
EP2319941A3 (en) Method and apparatus for correlating levels of biomarker products with disease
CN105044361B (en) A kind of diagnostic marker and its screening technique for being suitable for esophageal squamous cell carcinoma early diagnosis
WO2005094332A3 (en) Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators in non-small cell lung cancer
DK1200832T3 (en) Annexins and autoantibodies used as markers for lung cancer and oesophageal cancer
EP1975623A3 (en) Sample analyzer
EP2667194A3 (en) Ratio based biomarkers and methods of use thereof
DE60129151D1 (en) METHOD FOR DETECTING EGG CANCER BY MEANS OF HUMAN CALLIQUE (HK6)
KR100711046B1 (en) Use of nicotinamide n-methyltransferase as a marker for colorectal cancer
JP2014501388A (en) Protein profiles of cancer and other pathological entities by selective response monitoring (SRM)
CA2701341A1 (en) Method of assessing colorectal cancer from a stool sample by use of the marker combination calprotectin and hemoglobin/haptoglobin complex
MX340856B (en) System and methods for determination of analyte concentration using time resolved amperometry.
SG183220A1 (en) Phospholipid profiling and cancer
SG165370A1 (en) Method for the diagnosis of colorectal cancer and ovarian cancer by the measurement of vitamin e-related metabolites
US20180149598A1 (en) Label-free detection of small and large molecule interactions, and activities in biological systems
HK1115636A1 (en) Use of cyfra 21-1 as a marker for colorectal cancer cyfra 21-1
Hoesl et al. Internal standardization of LA-ICP-MS immuno imaging via printing of universal metal spiked inks onto tissue sections
CA2623653A1 (en) Use of n-myristoyltransferase on non-tumor tissue for cancer diagnosis
Ziegler et al. Proteomic surfaceome analysis of mesothelioma
Faix et al. Progress in standardizing and harmonizing thyroid function tests
CN109313195B (en) Method for providing diagnosis information of biliary tract cancer and apparatus for diagnosing biliary tract cancer
HK1136873A1 (en) Use of nnmt as a marker for lung cancer
DE602005013430D1 (en) USING ASC AS A MARKER FOR COLORECTAL CARCINOMAS
WO2020204373A3 (en) Apparatus for diagnosing solid cancers and method for providing information on solid cancer diagnosis
CN109425739A (en) One histone is preparing the purposes in diagnosis of malignant tumor reagent and kit as tumor markers
Beattie et al. Raman spectroscopy for the detection of AGEs/ALEs

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 20782471

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2021572576

Country of ref document: JP

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: 2020782471

Country of ref document: EP

Effective date: 20211102