WO2020183437A1 - Systèmes et procédés pour détection spectrale d'agent pathogènes résistants aux médicaments. - Google Patents

Systèmes et procédés pour détection spectrale d'agent pathogènes résistants aux médicaments. Download PDF

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Publication number
WO2020183437A1
WO2020183437A1 PCT/IB2020/052339 IB2020052339W WO2020183437A1 WO 2020183437 A1 WO2020183437 A1 WO 2020183437A1 IB 2020052339 W IB2020052339 W IB 2020052339W WO 2020183437 A1 WO2020183437 A1 WO 2020183437A1
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WIPO (PCT)
Prior art keywords
sample
treatment
spectroscopy
pathogen
spectra
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PCT/IB2020/052339
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English (en)
Inventor
Philip Robert Heraud
Kamila KOCHAN
Bayden Robert Wood
Anton PELEG
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Monash University
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Publication date
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Publication of WO2020183437A1 publication Critical patent/WO2020183437A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/42—Low-temperature sample treatment, e.g. cryofixation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/44—Sample treatment involving radiation, e.g. heat
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N2021/0106—General arrangement of respective parts
    • G01N2021/0118—Apparatus with remote processing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N2021/3595—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using FTIR
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N2021/751—Comparing reactive/non reactive substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

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  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

Procédés de détermination de la susceptibilité ou de la résistance au traitement d'un agent pathogène comprenant la collecte de spectres à partir d'un agent pathogène cultivé avec un traitement et à partir du même agent pathogène cultivé sans le traitement. Les spectres sont comparés pour déterminer la susceptibilité ou la résistance de l'agent pathogène au traitement. L'invention concerne également des systèmes pour déterminer la susceptibilité ou la résistance au traitement d'un agent pathogène et peuvent comprendre un réseau informatique à distance, pouvant être basé sur un nuage.
PCT/IB2020/052339 2019-03-13 2020-03-13 Systèmes et procédés pour détection spectrale d'agent pathogènes résistants aux médicaments. WO2020183437A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962818039P 2019-03-13 2019-03-13
US62/818,039 2019-03-13

Publications (1)

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WO2020183437A1 true WO2020183437A1 (fr) 2020-09-17

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PCT/IB2020/052339 WO2020183437A1 (fr) 2019-03-13 2020-03-13 Systèmes et procédés pour détection spectrale d'agent pathogènes résistants aux médicaments.

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WO (1) WO2020183437A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023288096A1 (fr) * 2021-07-16 2023-01-19 The Regents Of The University Of California Détermination rapide de maladie dans des cellules de substitution à l'aide d'une lumière infrarouge
WO2023118904A1 (fr) * 2021-12-23 2023-06-29 The University Of Liverpool Hydrogels et leurs utilisations

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990009454A1 (fr) * 1989-02-09 1990-08-23 Bruker Analytische Messtechnik Gmbh Procede et dispositif pour tester rapidement l'efficacite d'agents chimiques sur des micro-organismes
US20050123917A1 (en) * 2001-11-12 2005-06-09 Synthon Kg Method for characterising and/or identifying active mechanisms of antimicrobial test substances
US20160177366A1 (en) * 2013-08-07 2016-06-23 Seraph Biosciences, Llc Hand-held micro-raman based detection instrument and method of detection
US20180355399A1 (en) * 2015-11-27 2018-12-13 bioMérieux Method for determining the reaction of a microorganism to its exposure to a chemical compound

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990009454A1 (fr) * 1989-02-09 1990-08-23 Bruker Analytische Messtechnik Gmbh Procede et dispositif pour tester rapidement l'efficacite d'agents chimiques sur des micro-organismes
US20050123917A1 (en) * 2001-11-12 2005-06-09 Synthon Kg Method for characterising and/or identifying active mechanisms of antimicrobial test substances
US20160177366A1 (en) * 2013-08-07 2016-06-23 Seraph Biosciences, Llc Hand-held micro-raman based detection instrument and method of detection
US20180355399A1 (en) * 2015-11-27 2018-12-13 bioMérieux Method for determining the reaction of a microorganism to its exposure to a chemical compound

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
AJESH K. ET AL.: "Cryptococcus laurentii Biofilms: Structure, Development and Antifungal Drug Resistance", MYCOPATHOLOGIA, vol. 174, 2012, pages 409 - 419 *
ATHAMNEH, A.I.M ET AL.: "Phenotypic Profiling of Antibiotic Response Signatures in Escherichia coli Using Raman Spectroscopy", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 58, no. 3, March 2014 (2014-03-01), pages 1302 - 1314, XP055290095, DOI: 10.1128/AAC.02098-13 *
PREMASIRI W. R. ET AL.: "Rapid urinary tract infection diagnostics by surface-enhanced Raman spectroscopy (SERS): identification and antibiotic susceptibilities", ANAL BIOANAL CHEM, vol. 409, 2017, pages 3043 - 3054, XP036198155, DOI: 10.1007/s00216-017-0244-7 *
QUILES F. ET AL.: "AFM combined to ATR-FTIR reveals Candida cell wall changes under caspofungin treatment", NANOSCALE, vol. 9, no. 36, 2017, pages 13731 - 13738, XP055739382 *
SHARAHA U. ET AL.: "Using Infrared Spectroscopy and Multivariate Analysis to Detect Antibiotics' Resistant Escherichia coli Bacteria", ANAL. CHEM., vol. 89, no. 17, 5 September 2017 (2017-09-05), pages 8782 - 8790, XP055739386 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023288096A1 (fr) * 2021-07-16 2023-01-19 The Regents Of The University Of California Détermination rapide de maladie dans des cellules de substitution à l'aide d'une lumière infrarouge
WO2023118904A1 (fr) * 2021-12-23 2023-06-29 The University Of Liverpool Hydrogels et leurs utilisations

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