WO2020181430A1 - 一种人造血管 - Google Patents

一种人造血管 Download PDF

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Publication number
WO2020181430A1
WO2020181430A1 PCT/CN2019/077539 CN2019077539W WO2020181430A1 WO 2020181430 A1 WO2020181430 A1 WO 2020181430A1 CN 2019077539 W CN2019077539 W CN 2019077539W WO 2020181430 A1 WO2020181430 A1 WO 2020181430A1
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blood vessel
layer
layer blood
artificial
anastomosis
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PCT/CN2019/077539
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English (en)
French (fr)
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孟国伟
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孟国伟
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Priority to PCT/CN2019/077539 priority Critical patent/WO2020181430A1/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels

Definitions

  • the invention relates to the technical field of medical equipment, in particular to an artificial blood vessel.
  • the object of the present invention is to provide an artificial blood vessel to solve the problems raised in the background art.
  • An artificial blood vessel includes an outer layer of blood vessel, the outer layer of blood vessel is nested with an inner layer of blood vessel, and the inner wall of the outer layer of blood vessel is provided with a connection point connected with the inner layer of blood vessel.
  • connection point is connected with one end of the inner blood vessel.
  • the length of the inner blood vessel is greater than the length of the outer blood vessel used for anastomosis, that is, the length of the inner blood vessel exceeds the anastomosis.
  • the diameter of the inner blood vessel is smaller than the diameter of the outer blood vessel, and the outer diameter of the inner blood vessel is approximately equal to the inner diameter of the outer blood vessel.
  • the material of the outer blood vessel is a biocompatible material.
  • the material of the inner blood vessel is a biocompatible material.
  • the biocompatible material includes polyurethane.
  • connection is connected with the middle of the inner blood vessel.
  • the present invention has the following beneficial effects: by nesting the inner blood vessel connected to the inner wall of the outer blood vessel, the outer blood vessel is connected when the artificial blood vessel is connected, and the length of the inner blood vessel exceeds the anastomosis.
  • the blood pressure makes the inner blood vessel stick to the anastomosis, sealing, isolating and oppressing the anastomosis and the suture needle, so as to prevent the anastomosis and the suture needle from bleeding, and it is safer to use Convenience.
  • Figure 1 is a schematic diagram of the structure of an artificial blood vessel
  • Figure 2 is a schematic diagram of the structure of the artificial blood vessel before anastomosis
  • Figure 3 is a schematic view of the structure of the artificial blood vessel anastomosis
  • Figure 4 is a schematic diagram of the structure of the artificial blood vessel after anastomosis
  • Fig. 5 is a schematic diagram of another structure of the artificial blood vessel.
  • first and second are only used for descriptive purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of indicated technical features. Thus, the features defined with “first” and “second” may explicitly or implicitly include one or more of these features. In the description of the present invention, “plurality” means two or more than two, unless specifically defined otherwise.
  • the terms “installed”, “connected”, “connected”, “fixed” and other terms should be understood in a broad sense, for example, it can be a fixed connection or a detachable connection. , Or integrated; it can be braided and stitched connection or mechanical connection; it can be directly connected, or indirectly connected through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements.
  • installed can be a fixed connection or a detachable connection. , Or integrated; it can be braided and stitched connection or mechanical connection; it can be directly connected, or indirectly connected through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements.
  • the artificial blood vessel as shown in Figures 1-4 includes an outer layer of blood vessel 1.
  • the outer layer of blood vessel 1 is nested with an inner layer of blood vessel 2 and the inner wall of the outer layer of blood vessel 1 is provided with a connection 3 connected to the inner layer of blood vessel 2.
  • the outer blood vessel 1 is anastomosed with the autogenous blood vessel or other artificial blood vessels, that is, the outer blood vessel 1 is sutured with sutures ,
  • the length of the inner blood vessel 2 exceeds the anastomosis, because the inner blood vessel 2 is connected to the outer blood vessel 1 through the junction 3, when the blood flows through the inner blood vessel 2, the blood flows from the inner blood vessel 2, and the inner blood vessel 2 Under the action of blood pressure, it sticks to the anastomosis, sealing, isolating and oppressing the anastomosis and the suture needle, so as to achieve the effect of preventing the anastomosis and the suture needle from bleeding.
  • the junction 3 is connected to one end of the inner blood vessel 2.
  • the outer blood vessel 1 By connecting one end of the inner blood vessel 2 to the outer blood vessel 1, and the other parts are separated from the outer blood vessel 1, it is convenient for the outer blood vessel 1 to be connected to the autogenous blood vessel or the artificial blood vessel.
  • Anastomosis can also fix the inner blood vessel 2 and guide the blood flow through the inner blood vessel 2 to make the inner blood vessel 2 stick to the anastomosis.
  • the anastomosis and the suture needle can be sealed, isolated, and compressed to achieve the purpose of hemostasis.
  • the length of the inner blood vessel 2 is greater than the length of the outer blood vessel 1 used for anastomosis, that is, the length of the inner blood vessel 2 exceeds the length of the anastomosis, and the length of the inner blood vessel 2 is greater than the length of the outer blood vessel 1 at the end of the anastomosis to ensure the outer blood vessel 1 After anastomosis, the inner blood vessel 2 can completely seal the anastomosis.
  • the diameter of the inner blood vessel 2 is smaller than the diameter of the outer blood vessel 1, and the outer diameter of the inner blood vessel 2 is approximately equal to the inner diameter of the outer blood vessel 1 in order to make the inner blood vessel 2 and the outer blood vessel 1 fit tightly.
  • the outer layer blood vessel 1 and the inner layer blood vessel 2 are made of biocompatible materials, including any one of polyurethane and expanded polytetrafluoroethylene.
  • Polyurethane and expanded polytetrafluoroethylene not only meet the requirements of mechanical properties, but also The compatibility is good, and rejection reaction is not easy to occur.
  • the difference between this embodiment and Embodiment 1 is that the junction 3 is connected to the middle of the inner blood vessel 2, and both ends of the outer blood vessel 1 can be anastomosed.
  • the artificial blood vessel of the present invention can also be cut into a double-layer patch and used as a material for repairing defects such as blood vessels, for example, when performing aortic sinus replacement or repair (such as DAVID surgery).
  • the working principle is as follows: when the artificial blood vessel is replaced or connected, the outer blood vessel 1 is anastomosed with the autogenous blood vessel or other artificial blood vessels, that is, the outer blood vessel 1 is sutured with sutures, and the length of the inner blood vessel exceeds the anastomosis. Since the inner blood vessel 2 is connected to the outer blood vessel 1 through the connection 3, blood flows from the inner blood vessel 2, and the inner blood vessel 2 is attached to the anastomosis under the pressure of blood flow, sealing and isolating the anastomosis and the suture needle. , Compression, so as to achieve the effect of preventing anastomotic bleeding.

Abstract

一种人造血管，包括外层血管（1），外层血管（1）内嵌套设置有内层血管（2），外层血管（1）内壁设有与内层血管（2）相连的连接处（3），连接处（3）与内层血管（2）的一端或中间相连；通过在外层血管（1）内嵌套与其内壁相连的内层血管（2），在连接人工血管时将外层血管（1）相连，内层血管（2）长度大于用于吻合的外层血管（1）的长度，即内层血管（2）的长度超越吻合口；当血液流经内层血管（2）时，血流压力使内层血管（2）贴向吻合口，对吻合口及缝合针眼起到封闭、隔离、压迫作用，从而达到防止吻合口及缝合针眼出血的效果，使用时更安全方便。

Description

一种人造血管 技术领域
本发明涉及医疗器材技术领域，具体是一种人造血管。
背景技术
人造血管是血管外科及心脏外科常用的血管替换或修复材料。目前的人造血管在进行替换时，如果血管有夹层，或血管壁出现严重硬化、钙化等病变，吻合口及缝合针眼常常严重出血，以往采用加针缝合、血管外面压迫、止血材料、止血药物或血液制品等措施止血，止血效果差。
发明内容
本发明的目的在于提供一种人造血管，以解决上述背景技术中提出的问题。
为实现上述目的，本发明提供如下技术方案：
一种人造血管，包括外层血管，所述外层血管内嵌套设置有内层血管，外层血管内壁设有与内层血管相连的连接处。
作为本发明的进一步技术方案：所述连接处与内层血管的一端相连。
作为本发明的更进一步技术方案：所述内层血管的长度大于用于吻合的外层血管的长度，即内层血管长度超越吻合口。
作为本发明的再进一步技术方案：内层血管的直径小于外层血管的直径，内层血管外径约等于外层血管内径。
作为本发明的再进一步技术方案：所述外层血管材质为生物相容性材料。
作为本发明的再进一步技术方案：所述内层血管材质为生物相容性材料。
作为本发明的再进一步技术方案：所述生物相容性材料包括聚氨酯。
作为本发明的再进一步技术方案：所述连接处与内层血管的中间相连。
与现有技术相比，本发明的有益效果是：通过在外层血管内嵌套与其内壁相连的内层血管，在连接人工血管时将外层血管相连，内层血管长度超越吻合口，当血液流经内层血管时，血流压力使内层血管贴向吻合口，对吻合口及缝合针眼起到封闭、隔离、压迫作用， 从而达到防止吻合口及缝合针眼出血的效果，使用时更安全方便。
附图说明
图1为人造血管的结构示意图；
图2为人造血管吻合前的结构示意图；
图3为人造血管吻合中的结构示意图；
图4为人造血管吻合后的结构示意图；
图5为人造血管的另一种结构示意图。
图中：1-外层血管、2-内层血管、3-连接处。
具体实施方式
在本发明的描述中，需要理解的是，术语“中间”、“纵向”、“横向”、“长度”、“宽度”、“厚度”、“上”、“下”、“前”、“后”、“左”、“右”、“竖直”、“水平”、“顶”、“底”“内”、“外”、“顺时针”、“逆时针”、“轴向”、“径向”、“周向”等指示的方位或位置关系为基于附图所示的方位或位置关系，仅是为了便于描述本发明和简化描述，而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作，因此不能理解为对本发明的限制。
此外，术语“第一”、“第二”仅用于描述目的，而不能理解为指示或暗示相对重要性或者隐含指明所指示的技术特征的数量。由此，限定有“第一”、“第二”的特征可以明示或者隐含地包括一个或者更多个该特征。在本发明的描述中，“多个”的含义是两个或两个以上，除非另有明确具体的限定。
在本发明中，除非另有明确的规定和限定，术语“安装”、“相连”、“连接”、“固定”等术语应做广义理解，例如，可以是固定连接，也可以是可拆卸连接，或成一体；可以是编织缝合连接，也可以是机械连接；可以是直接相连，也可以通过中间媒介间接相连，可以是两个元件内部的连通或两个元件的相互作用关系。对于本领域的普通技术人员而言，可以根据具体情况理解上述术语在本发明中的具体含义。
下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地 描述。
实施例1
如图1-4所示的人造血管，包括外层血管1，所述外层血管1内嵌套设置有内层血管2，外层血管1内壁设有与内层血管2相连的连接处3，通过嵌套设置的外层血管1和内层血管2，在进行人工血管替换或连接时，将外层血管1与自体血管或其他人工血管进行吻合，即使用缝线缝合在外层血管1上，而内层血管2长度超越吻合口，由于内层血管2通过连接处3与外层血管1相连，当血液流经内层血管2时，血液自内层血管2流动，内层血管2在血流压力作用下贴向吻合口，对吻合口及缝合针眼起到封闭、隔离、压迫作用，从而达到防止吻合口及缝合针眼出血的效果。
所述连接处3与内层血管2的一端相连，通过将内层血管2的一端与外层血管1相连，其他部分与外层血管1分离，既便于外层血管1与自体血管或人造血管吻合，又可以将内层血管2固定，引导血流通过内层血管2，使内层血管2贴向吻合口，对吻合口及缝合针眼进行封闭、隔离、压迫，以达到止血的目的。
所述内层血管2的长度大于用于吻合的外层血管1的长度，即内层血管2长度超越吻合口，内层血管2的长度大于吻合端的外层血管1的长度保证了外层血管1吻合后内层血管2能完全将吻合口封闭。
所述内层血管2的直径小于外层血管1的直径，内层血管2的外径约等于外层血管1内径，目的是使内层血管2与外层血管1贴合紧密。
所述外层血管1和内层血管2的材质均为生物相容性材料，包括聚氨酯和膨化聚四氟乙烯中的任意一种，聚氨酯和膨化聚四氟乙烯不仅满足力学性能的要求，而且相容性好，不易发生排斥反应。
实施例2
如图5所示，本实施例与实施例1的不同之处在于，所述连接处3与内层血管2的中间相连，外层血管1两端均可以吻合。
本发明的人工血管也可剪开成为双层补片，作为血管等修补缺损材料使用，例如在行 主动脉窦替换或修补(如DAVID手术)时使用。
工作原理如下：在进行人工血管替换或连接时，将外层血管1与自体血管或其他人工血管进行吻合，即使用缝线缝合在外层血管1上，而内层血管长度超越吻合口。由于内层血管2通过连接处3与外层血管1相连，血液自内层血管2流动，内层血管2在血流压力作用下贴向吻合口，对吻合口及缝合针眼起到封闭、隔离、压迫作用，从而达到防止吻合口出血的效果。
对于本领域技术人员而言，显然本发明不限于上述示范性实施例的细节，而且在不背离本发明的精神或基本特征的情况下，能够以其他的具体形式实现本发明。因此，无论从哪一点来看，均应将实施例看作是示范性的，而且是非限制性的，本发明的范围由所附权利要求而不是上述说明限定，因此旨在将落在权利要求的等同要件的含义和范围内的所有变化囊括在本发明内。不应将权利要求中的任何附图标记视为限制所涉及的权利要求。
此外，应当理解，虽然本说明书按照实施方式加以描述，但并非每个实施方式仅包含一个独立的技术方案，说明书的这种叙述方式仅仅是为清楚起见，本领域技术人员应当将说明书作为一个整体，各实施例中的技术方案也可以经适当组合，形成本领域技术人员可以理解的其他实施方式。

Claims (5)

  1. 一种人造血管，包括外层血管1，其特征在于：所述外层血管(1)内嵌套设置有内层血管(2)，外层血管(1)内壁设有与内层血管(2)相连的连接处(3)。
  2. 根据权利要求1所述的人造血管，其特征在于：所述连接处(3)与内层血管(2)的一端相连。
  3. 根据权利要求1或2所述的人造血管，其特征在于：所述内层血管(2)的长度大于用于吻合的外层血管(1)的长度。
  4. 根据权利要求3所述的人造血管，其特征在于：所述内层血管(2)的直径小于外层血管(1)的直径。
  5. 根据权利要求1所述的人造血管，其特征在于：所述连接处(3)与内层血管(2)的中间相连。
PCT/CN2019/077539 2019-03-08 2019-03-08 一种人造血管 WO2020181430A1 (zh)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1248157A (zh) * 1997-02-20 2000-03-22 恩朵罗杰克斯股份有限公司 分叉脉管移植物及其展开方法和装置
US6126686A (en) * 1996-12-10 2000-10-03 Purdue Research Foundation Artificial vascular valves
CN1555769A (zh) * 2004-01-08 2004-12-22 东南大学 防内漏易弯曲腔内隔绝人工血管支架及人工血管
CN107205744A (zh) * 2014-12-18 2017-09-26 因特利支架股份有限公司 可调节地介入性减少血流的支架和支架的套件
CN107789094A (zh) * 2017-11-22 2018-03-13 北京华脉泰科医疗器械有限公司 免缝合支架人工血管、超弹编织固定环

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6126686A (en) * 1996-12-10 2000-10-03 Purdue Research Foundation Artificial vascular valves
CN1248157A (zh) * 1997-02-20 2000-03-22 恩朵罗杰克斯股份有限公司 分叉脉管移植物及其展开方法和装置
CN1555769A (zh) * 2004-01-08 2004-12-22 东南大学 防内漏易弯曲腔内隔绝人工血管支架及人工血管
CN107205744A (zh) * 2014-12-18 2017-09-26 因特利支架股份有限公司 可调节地介入性减少血流的支架和支架的套件
CN107789094A (zh) * 2017-11-22 2018-03-13 北京华脉泰科医疗器械有限公司 免缝合支架人工血管、超弹编织固定环

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