WO2020168869A1

WO2020168869A1 - Liquid detection, analysis and mixing system

Info

Publication number: WO2020168869A1
Application number: PCT/CN2020/072267
Authority: WO
Inventors: 王永东; 刘阳
Original assignee: 重庆科斯迈生物科技有限公司
Priority date: 2019-02-20
Filing date: 2020-01-15
Publication date: 2020-08-27
Also published as: CN209784026U

Abstract

A liquid detection, analysis and mixing system, comprising a mixing seat (1), which is provided with an accommodating groove (10); a guide mechanism (2), which has a closed guide track, the mixing seat (1) being supported on the guide mechanism (2); and a driving mechanism (3), which is used to drive the mixing seat (1) to move along the guide track of the guide mechanism (2) so that the mixing seat (1) swings back and forth in a horizontal direction. By using the described solution, a linear guide rail and an eccentric shaft (31) cooperate to drive the mixing seat (1) to make circular movements in the horizontal direction, and the movements are smooth, so that liquid in a container in the accommodating groove (10) is evenly mixed, which will not directly affect the container. At the same time, the mixing effect may be greatly improved by means of forward and reverse direction movements. The overall structure is compact and less space is occupied.

Description

Liquid detection analysis mixing system

Technical field

The utility model relates to the field of medical detection equipment, in particular to a liquid detection, analysis and mixing system.

Background technique

In daily life and work, it usually involves the stirring and mixing of multiple liquids. How to improve the mixing effect has always been the direction of improvement of the mixing device. For example, in immunoassay experiments, chemiluminescence immunoassay methods are usually used to detect body fluids. In the analysis, in the detection process, the experimenter needs to use a special reaction cup to contain the body fluid to be tested, which usually goes through the steps of filling, mixing, incubating, washing, testing and cleaning. The traditional chemiluminescence immunoassay analyzer usually The mixing disc is used to hit the suspended reaction cup to achieve the mixing effect. For example, in the patent document with the publication number "CN107167468A" and the name "Magnetic particle chemiluminescence immunoassay analyzer", in the washing system, A shaking mechanism is arranged under the washing trolley, which is mainly used to achieve deflection and mixing by knocking on the reaction cup. On the one hand, the shaking mechanism can only mix the liquid in a single reaction cup, which increases the production cost of the equipment. On the other hand, because the thimble is in direct contact with the reaction cup, it is easy to damage the reaction cup, and may cause the liquid in the reaction cup to splash out due to excessive impact, and the overall mixing effect is not ideal.

Utility model content

In view of this, the utility model provides a liquid detection, analysis and mixing system, which can realize the overall mixing of the liquid in the container, and improve the mixing stability while ensuring the mixing effect.

The technical scheme is as follows:

A liquid detection, analysis and mixing system, the key is to include:

The mixing seat is provided with a containing groove;

A guiding mechanism, which has a closed guiding track, and the mixing seat is supported on the guiding mechanism;

The driving mechanism is used to drive the mixing seat to move along the guiding track of the guiding mechanism, so that the mixing seat reciprocates in the horizontal direction.

Using the above scheme, the driving mechanism drives the mixing seat to move and mix with the predetermined guiding track of the guiding mechanism. First, the smooth movement of the mixing seat can be ensured. At the same time, multiple liquid containers can be placed in the containing tank to achieve multiple The containers are mixed at the same time to improve the mixing efficiency, and fully ensure that the mixing effect in each container is consistent, and improve the universality of the test results.

Preferably, the driving mechanism includes an eccentric shaft and a motor that drives the eccentric shaft to rotate, and the eccentric shaft is fixedly connected to the mixing base. By adopting the above scheme, the eccentric shaft drives the mixing seat to rotate along with the guide mechanism, thereby ensuring that the mixing seat can return to the initial position after the mixing is completed, which is convenient to improve the automation degree of the liquid container putting in and taking out operation.

Preferably, a mounting seat is provided under the mixing seat, the eccentric shaft is fixed on the mounting seat through two lower bearings, the eccentric shaft is arranged vertically, and the upper end of the eccentric shaft is fixedly connected to the mixing seat through a connector, and The eccentric shaft is rotatably connected with the connecting head through the upper bearing, and the guide mechanism is fixed on the mounting seat. Two lower bearings are used to fix the eccentric shaft, which is beneficial to improve the rotation stability of the eccentric shaft and prevent deflection, which affects the stability of the mixing seat and causes the liquid to splash out. It is connected to the mixing seat through a connector to facilitate mixing. The separate production and manufacture of the homogenization seat reduces the structural changes to the homogenization seat and reduces the mold opening and manufacturing costs.

Preferably, the connecting head is L-shaped and includes a bottom support portion and a lateral connection portion, the bottom support portion abuts against the bottom of the mixing base, and the lateral connection portion is fixedly connected to one side of the mixing base . Because the parts have processing tolerances, the L-shaped connector is used to integrate these tolerances during assembly. The fit between the mixing seat and the L-shaped connector of this design can be adjusted up and down to improve the overall assembly.

Preferably, the guide mechanism includes X-direction guide rails and X-direction sliders that are slidingly matched, and Y-direction guide rails and Y-direction sliding blocks that are slidingly matched, wherein the X-direction guide rail is fixedly connected to the Y-direction sliding block and is connected to the Y-direction sliding block. The guide rails are perpendicular to each other, the mixing seat is fixedly connected with the X-direction sliding block, and the Y-direction guide rail is fixed on the mounting seat. Using the above solution, through the mutually perpendicular X-direction guide rail and Y-direction guide rail, driven by the drive mechanism, the circular motion of the mixing seat can be realized in the structure of a linear slide rail, which simplifies the guide rail structure and facilitates implementation. The circular guide rail is relatively directly used. In other words, its movement is relatively smoother and the manufacturing cost is lower.

Preferably, a mounting groove is provided on the mounting seat corresponding to the Y-direction guide rail. The above scheme is adopted to reduce the space occupation of the guide mechanism in the height direction and improve the overall compactness of the system.

Preferably, the mixing seat is arranged along the length direction of the mounting seat, and the containing groove penetrates both ends of the mixing seat. By adopting the above scheme, it is applied to an immunoassay analyzer, so that the cup strip can be directly inserted or pulled out from the end of the containing groove.

Preferably, two ends of the upper edge of the accommodating groove are symmetrically provided with elastic limit clips, the elastic limit clips are arranged along the length direction of the mixing seat, and the end of the elastic limit clips near the end of the accommodating groove A limit protrusion extending directly above the groove, the other end is fixed on the mixing seat. The adoption of the above solution is beneficial to ensure the stability of the cup strips placed in the accommodating tank, and prevents the cup strips from shaking relative to the mixing seat during the movement of the mixing seat, which affects the mixing effect.

Preferably, the X-direction guide rail is fixedly connected to the Y-direction sliding block through an intermediate block, the intermediate block has a sensing sheet protruding outward, and a reset sensor is provided on the mounting seat corresponding to the sensing sheet. By adopting the above solution, the reset sensor counts the number of movement and reset times of the sensing plate, thereby knowing the number of rotations of the mixing seat, which is convenient for replacement, and quantifies the mixing quality with the number of rotations, thereby improving the mixing effect.

Compared with the prior art, the beneficial effects of the utility model:

The liquid detection, analysis and mixing system adopting the above technical schemes drives the mixing seat to make a circular motion in the manner of the linear guide rail and the eccentric shaft, and its movement is smooth and smooth, thereby mixing the liquid in the container in the containing tank as a whole, and also It will not directly affect the container, and at the same time, the mixing effect can be greatly improved through forward and reverse movement, the overall structure is compact, and the space is less occupied.

Description of the drawings

Figure 1 is a schematic diagram of the structure of the utility model;

Figure 2 is a perspective view of the embodiment shown in Figure 1;

Figure 3 is an exploded view of Figure 2;

Figure 4 is a top view of Figure 2;

Figure 5 is a schematic diagram of the eccentric shaft structure;

Figure 6 is a schematic diagram of the cup bar structure.

detailed description

Hereinafter, the present utility model will be further described in conjunction with the embodiments and the drawings.

Referring to Figures 1 to 5, the liquid detection, analysis and mixing system of the present application mainly includes three parts: a mixing seat 1, a guide mechanism 2, and a driving mechanism 3. The mixing seat 1 is provided with a containing groove 10, The accommodating groove 10 is mainly used to place and fix the container with liquid. The driving mechanism 3 is used to drive the mixing seat 1 to move with the guiding track of the guiding mechanism 2, and the guiding mechanism 2 is in the driving mechanism 3. There is a closed guiding track under linkage.

Its specific structure is as follows, referring to Figures 1 and 3, the mixing seat 1 is generally elongated, with a mounting seat 4 below it, and the driving mechanism 3 mainly includes a motor 30 and an eccentric shaft 31. As shown in the figure, the eccentric shaft 31 adopts The conventional eccentric structure has two eccentric parts, the lower end of which is rotatably supported on the mounting seat 4 through two lower bearings 40, and corresponds to one end of the mixing seat 1, the motor 30 is vertically arranged, and the eccentric shaft 31 is fixed with For the sprocket 310, the motor 30 can drive the eccentric shaft 31 to rotate through the timing belt 32, the motor shaft of the motor 30 is fixedly sleeved with a timing wheel, and the timing belt 32 is sleeved on the sprocket 310 and the timing wheel.

The eccentric shaft 31 is arranged vertically, and its upper end is fixedly connected to the mixing base 1 through a connector 5. As shown in the figure, the connector 5 is generally L-shaped and includes an integrally formed bottom support portion 51 and a lateral connection portion 52. The upper end of the eccentric shaft 31 is rotatably fitted with the bottom support portion 51 through the upper bearing 50, and the lateral connection portion 52 is fixedly connected to one side of the mixing seat 1 by screws, and the bottom support portion 51 is connected to the mixing seat The bottom of 1 is also fixedly connected, because the eccentric shaft 31 has a certain centrifugal force during the rotation, the lateral connecting part 52 can better use the centrifugal force to drive the mixing seat 1 to move, and the L-shaped connector 5 can be fully integrated Parts processing tolerances.

The mixing mechanism 2 is located at the end of the mounting seat 4 away from the eccentric shaft 31, and it mainly includes an X-direction guide rail 20 and an X-direction sliding block 21 that are slidingly matched with each other, and a sliding-matched Y-direction guide rail 22 and a Y-direction sliding block 23. The X-direction guide rail 20 is fixedly connected to the Y-direction slider 23 through the intermediate block 24, and the X-direction guide rail 20 and the Y-direction guide rail 22 are perpendicular to each other. In this embodiment, the X-direction guide rail 20 is arranged along the length of the mounting base 4, and the Y-direction guide rail 22 is arranged along the width direction of the mounting base, wherein the mixing base 1 is fixedly connected to the X-direction slider 21, and the Y-direction guide rail 22 is fixed on the mounting base 4.

In this embodiment, in order to fully save installation space, a mounting slot 41 is provided on the mounting base 4 corresponding to the Y-direction guide rail 22. The size of the mounting slot 41 is adapted to the size of the Y-direction slider 23, and the Y-direction guide rail 22 is completely embedded and installed. In the groove 41, the Y-direction slider 23 is partially embedded in the installation groove 41, thereby greatly reducing the height of the guide mechanism 2 protruding from the installation seat 4.

In addition, the end of the middle block 24 away from the eccentric shaft 31 has a sensing piece 240 extending outward along its length. A reset sensor 42 is provided on the mounting seat 4 corresponding to the sensing piece 240. In this embodiment, the reset sensor 42 is a counting sensor When the middle block 24 reciprocates, the reset sensor 42 can be triggered multiple times to achieve the counting purpose, so as to better control the mixing effect with quantified data.

In this embodiment, the mixing seat 1 is made of metal material, the accommodating groove 10 has a through groove structure that penetrates both ends, and the upper part of the accommodating groove 10 is open, and the upper edge of the accommodating groove 10 is provided with an elastic limit card Strip 11, the elastic limit clip 11 is located at both ends of the accommodating groove 10, and is arranged symmetrically along the length direction of the accommodating groove 10, both ends of the elastic limit clip 11, the elastic limit clip 11 is made of plastic material, Its end close to the end of the accommodating groove 10 has a limiting protrusion 110 that extends directly above the accommodating groove 10, and the elastic limiting clip 11 is mainly fixedly inserted into it by the limiting protrusion 110 Cup bars.

With reference to Figures 1 to 6, the liquid detection, analysis and mixing system of the present invention is used in immunoassays to mix the reaction cup on the cup strip 6. As shown in the figure, the cup strip 6 has a lengthwise distribution There are symmetrical grooves 60 on both sides of the end of the cup strip 6, and the grooves 60 have an arc-shaped groove structure and are arranged along the height direction of the cup strip 6.

When in use, when the mixing seat 1 is in a static state, the cup strip 6 can enter from one end of the containing groove 10, and the limiting protrusion 110 just snaps into the card slot 60, so as to realize the fixing of the cup strip 6 and avoid mixing During the process, relative movement occurs between the cup bar 6 and the mixing seat 1, and the motor 30 is started. Through the cooperation of the eccentric shaft 31 and the guide mechanism 2, the mixing seat 1 moves in a circular motion without rotating itself. Ensure that the movement trajectory of each point on the cup strip 6 is consistent, so that the mixing effect of the reagents in the reaction cups in the cup holder 61 is the same, ensuring stable mixing, and good mixing efficiency, improving the generality of the test results Sex.

During the mixing process, by resetting the sensor 42 to record the number of touches of the sensing plate 240, you can know how many revolutions the mixing seat 1 has rotated in total. At the same time, by changing the rotation direction of the motor 30, the positive and negative mixing is realized and the mixing effect is further improved. The reset sensor 42 records the parameters, which facilitates the optimization of the mixing time and is beneficial to improve the degree of automation of the mixing.

Finally, it should be noted that the above description is only a preferred embodiment of the utility model. Under the enlightenment of the utility model, those of ordinary skill in the art can make many things without violating the purpose of the utility model and the claims. A similar expression, such transformations fall within the protection scope of the present invention.

Claims

A liquid detection, analysis and mixing system is characterized in that it comprises:

The mixing seat (1) is provided with a containing groove (10);

A guiding mechanism (2), which has a closed guiding track, and the mixing seat (1) is supported on the guiding mechanism (2);

The driving mechanism (3) is used for driving the mixing seat (1) to move along the guiding track of the guiding mechanism (2), so that the mixing seat (1) reciprocates in the horizontal direction.
The liquid detection, analysis and mixing system according to claim 1, wherein the driving mechanism (3) comprises an eccentric shaft (31) and a motor (30) that drives the eccentric shaft (31) to rotate, and the eccentric shaft The two ends of (31) are respectively connected with the mixing seat (1) and the motor (30).
The liquid detection, analysis and mixing system according to claim 1 or 2, wherein a mounting seat (4) is provided under the mixing seat (1), and the eccentric shaft (31) passes through two lower bearings ( 40) is fixed on the mounting seat (4), the eccentric shaft (31) is arranged vertically, and its upper end is fixedly connected with the mixing seat (1) through the connector (5), and the eccentric shaft (31) passes through the upper bearing ( 50) is connected with the connecting head (5) in a rotatable manner, and the guide mechanism (2) is fixed on the mounting seat (4).
The liquid detection, analysis and mixing system according to claim 3, characterized in that: the connecting head (5) is L-shaped, which includes a bottom supporting portion (51) and a lateral connecting portion (52), the bottom supporting The portion (51) abuts against the bottom of the mixing seat (1), and the lateral connecting portion (52) is fixedly connected to one side of the mixing seat (1).
The liquid detection, analysis and mixing system according to claim 3, characterized in that: the guide mechanism (2) comprises a slidingly matched X-direction guide rail (20) and an X-direction slider (21), and a slidingly matched Y-direction The guide rail (22) and the Y-direction slide block (23), wherein the X-direction guide rail (20) is fixedly connected to the Y-direction slide block (23) and is perpendicular to the Y-direction guide rail (22). The mixing seat ( 1) It is fixedly connected with the X-direction sliding block (21), and the Y-direction guide rail (22) is fixed on the mounting seat (4).
The liquid detection, analysis and mixing system according to claim 5, characterized in that: the mounting seat (4) is provided with a mounting groove (41) at a position corresponding to the Y-direction guide rail (22).
The liquid detection, analysis and mixing system according to claim 3, characterized in that: the mixing seat (1) is arranged along the length of the mounting seat (4), and the containing groove (10) penetrates the mixing seat ( 1) Both ends.
The liquid detection, analysis and mixing system according to claim 7, characterized in that: two ends of the upper edge of the containing groove (10) are symmetrically provided with elastic limit clip strips (11), and the elastic limit clip strips (11) It is arranged along the length direction of the mixing seat (1), one end of which is close to the end of the containing groove (10) has a limiting protrusion (110) extending directly above the containing groove (10), and the other end is fixed at On the mixing seat (1).
The liquid detection, analysis and mixing system according to claim 5 or 6, characterized in that the X-direction guide rail (20) is fixedly connected to the Y-direction slider (23) through an intermediate block (24), and the intermediate block ( 24) There is a sensing sheet (240) protruding outwards, and a reset sensor (42) is provided on the mounting seat (4) corresponding to the sensing sheet (240).