WO2020149067A1 - Static mixer - Google Patents

Static mixer Download PDF

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Publication number
WO2020149067A1
WO2020149067A1 PCT/JP2019/048793 JP2019048793W WO2020149067A1 WO 2020149067 A1 WO2020149067 A1 WO 2020149067A1 JP 2019048793 W JP2019048793 W JP 2019048793W WO 2020149067 A1 WO2020149067 A1 WO 2020149067A1
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WO
WIPO (PCT)
Prior art keywords
liquid
mixer
turbulent diffusion
turbulent
static mixer
Prior art date
Application number
PCT/JP2019/048793
Other languages
French (fr)
Japanese (ja)
Inventor
坊之下雅夫
矢野弘樹
飯島里枝
磯谷篤志
亀澤一寿
吉田健吾
茂木智博
桑嶋幹
Original Assignee
日本分光株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 日本分光株式会社 filed Critical 日本分光株式会社
Priority to EP19910459.7A priority Critical patent/EP3912710A4/en
Priority to JP2020566154A priority patent/JP7343191B2/en
Publication of WO2020149067A1 publication Critical patent/WO2020149067A1/en

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/45—Mixing liquids with liquids; Emulsifying using flow mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
    • B01F25/43195—Wires or coils
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4338—Mixers with a succession of converging-diverging cross-sections, i.e. undulating cross-section
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B01F25/452—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces
    • B01F25/4522—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces the components being pressed through porous bodies, e.g. flat plates, blocks or cylinders, which obstruct the whole diameter of the tube
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/82—Combinations of dissimilar mixers
    • B01F33/821—Combinations of dissimilar mixers with consecutive receptacles

Definitions

  • the present invention relates to improvement of mixing efficiency in a mixer for mixing liquids, particularly in a static mixer for mixing two or more kinds of liquids.
  • static mixers have been used to mix liquids in various analytical fields such as liquid chromatography.
  • various types of static mixers and various innovations have been made according to their use.
  • various kinds of liquids and the like to be mixed and various devises have been made in order to be able to cope with these liquids and the like as a mixer and to increase the mixing efficiency.
  • Patent Document 1 a cross section of a cylindrical internal space of a pipe is divided into two, and a twisting blade element is arranged so as to form two flow paths, and the two twisting blade elements are formed.
  • a fluid agitator static mixer
  • Patent Document 2 a plurality of valves (ball valves or butterfly valves) are arranged in series in a half-open state inside a pipe, and adjacent valves are set to have different phases around the valve axis.
  • a technique relating to a fluid mixing apparatus capable of promoting turbulent flow of a liquid or the like that has passed therethrough and realizing sufficient mixing.
  • the stirring action can be improved by adding a simple device to the structure of the conventional static mixer in which a hole is provided at a predetermined position of the twisting blade element. Since the mixing is performed by the conventional mechanism, it cannot be said that the mixing efficiency is significantly improved.
  • Patent Document 2 by arranging a plurality of valves in series, turbulence can be promoted and sufficient mixing can be realized.
  • it is still the same as the conventional method. Therefore, it is extremely difficult to significantly improve the mixing efficiency, and there is still room for improvement.
  • the present invention has been made in view of the above-mentioned problems of the prior art, and its object is to improve mixing efficiency as compared with a conventional static mixer, and to compare with a dynamic mixer having a power unit. It is to provide a static mixer having a mixing efficiency without.
  • the static mixer A liquid inflow port into which two or more kinds of liquids flow, a liquid mixing unit connected to a rear stage of the liquid inflow and mixing the two or more kinds of liquids, and a liquid connected to a rear stage of the liquid mixing unit and mixed.
  • a static mixer having a liquid outlet that flows out,
  • the liquid mixing unit is a substantially cylindrical elongated capillary mixer that mixes the liquid by a turbulent flow with a twisted spiral rod provided inside, and a mixing chamber that is located at a subsequent stage of the capillary mixer and that mixes the liquid that has flowed in inside.
  • the mixing chamber has at least a larger volume than the capillary mixer,
  • the liquid mixing unit is characterized in that at least two turbulent diffusion mixer sections are connected in series.
  • the liquid mixing unit includes a first turbulent diffusion mixer section located on the liquid inlet side, and a second turbulent diffusion mixer section located on the liquid outlet side with respect to the first turbulent diffusion mixer section.
  • a first turbulent diffusion mixer section located on the liquid inlet side
  • a second turbulent diffusion mixer section located on the liquid outlet side with respect to the first turbulent diffusion mixer section.
  • Have The liquid volume of the first turbulent diffusion mixer section is larger than the liquid volume of the second turbulent diffusion mixer section.
  • the liquid mixing unit includes a first turbulent diffusion mixer section located on the liquid inlet side, and a second turbulent diffusion mixer section located on the liquid outlet side with respect to the first turbulent diffusion mixer section.
  • the liquid volume of the first turbulent diffusion mixer section is substantially the same as the liquid volume of the second turbulent diffusion mixer section.
  • the liquid mixing unit includes a first turbulent diffusion mixer section located on the liquid inlet side, and a second turbulent diffusion mixer section located on the liquid outlet side with respect to the first turbulent diffusion mixer section.
  • a first turbulent diffusion mixer section located on the liquid inlet side
  • a second turbulent diffusion mixer section located on the liquid outlet side with respect to the first turbulent diffusion mixer section.
  • Have The liquid volume of the first turbulent diffusion mixer section is smaller than the liquid volume of the second turbulent diffusion mixer section.
  • the liquid mixing unit includes a first turbulent diffusion mixer section located on the liquid inlet side, and a second turbulent diffusion mixer section located on the liquid outlet side with respect to the first turbulent diffusion mixer section.
  • the liquid mixing unit includes a third turbulent flow diffusion mixer section located closer to the liquid outlet than the second turbulent flow diffusion mixer section.
  • the liquid outlet part may be provided with a twisted spiral plate therein, and the twisted spiral plate may further mix the liquid mixed in the liquid mixing unit to flow the liquid out of the static mixer.
  • the static mixer has a switching valve mechanism that switches series connection in a plurality of liquid mixing units, and the liquid volume of the liquid mixing unit is variable by the switching operation of the switching valve mechanism.
  • the static mixer is characterized in that the liquid volume of the liquid mixing unit is variable by connecting at least two turbulent flow diffusion mixer parts to each other by piping.
  • the liquid mixing unit has a characteristic turbulent diffusion mixer section having a capillary mixer and a mixing chamber located at the subsequent stage, and at least two turbulent diffusion mixer sections are connected in series.
  • FIG. 3 is a schematic view of a structure in which a connecting portion between a capillary mixer and a mixing chamber has an angle in the static mixer according to the embodiment of the present invention.
  • FIG. 3 is a schematic view of a static mixer according to an embodiment of the present invention in which a twisted spiral plate is provided at a liquid outlet.
  • FIG. 3 is a schematic view of a static mixer according to an embodiment of the present invention in which a liquid outlet has a porous body.
  • the schematic diagram of another structure provided with the porous body in the static mixer which concerns on this embodiment is shown.
  • FIG 3 is a schematic configuration diagram in the case where three turbulent diffusion mixer sections are connected in series in the static mixer according to the embodiment of the present invention.
  • the schematic block diagram of the modification in the static mixer which concerns on embodiment of this invention is shown.
  • the schematic block diagram of the modification in the static mixer which concerns on embodiment of this invention is shown.
  • the schematic block diagram of the modification in the static mixer which concerns on embodiment of this invention is shown.
  • the schematic block diagram of the modification in the static mixer which concerns on embodiment of this invention is shown.
  • the image figure of the measurement result of the baseline fluctuation and noise by gradient liquid sending is shown.
  • FIG. 1 shows a schematic configuration diagram of a static mixer according to an embodiment of the present invention.
  • the static mixer 10 shown in the figure includes a liquid inlet 12 into which two or more kinds of liquids flow, a liquid mixing unit 14 connected to a subsequent stage of the liquid inlet 12 to mix the two or more kinds of liquids, and the liquid. And a liquid outlet 16 which is connected to the subsequent stage of the mixing unit 14 and through which the mixed liquid flows out.
  • the liquid inlet 12 is provided to allow the liquid from the outside to flow into the static mixer 10.
  • two or more liquid tanks and a liquid flow path from the liquid tank to the liquid inlet 12 are connected to the liquid inlet 12 (not shown).
  • the liquid tanks contain different kinds of liquids, that is, two or more kinds of liquids flow into the liquid inlet 12 from the outside of the static mixer 10.
  • the liquid mixing unit 14 includes a first turbulent diffusion mixer section 20 located on the liquid inlet 12 side and a second turbulent diffusion section located on the liquid outlet 16 side with respect to the first turbulent diffusion mixer section 20.
  • the mixer unit 30 is connected in series. In this embodiment, two or more kinds of liquids are efficiently mixed by utilizing the first turbulent flow diffusion mixer section 20 and the second turbulent flow diffusion mixer section 30 having this characteristic structure.
  • the first turbulent flow diffusion mixer section 20 includes a capillary mixer 22 that mixes two or more kinds of liquids by a turbulent flow with a twisted spiral rod 26 provided inside, and a liquid that is positioned downstream of the capillary mixer 22 and flows into the inside. And a mixing chamber 24 for mixing by diffusion.
  • the capillary mixer 22 is composed of a substantially cylindrical elongated pipe containing stainless steel, PEEK (polyether ether ketone), PTFE (polytetrafluoroethylene), and the like.
  • the inner diameter of the capillary mixer 22 is preferably about 0.25 to 3 mm, particularly preferably about 0.5 to 2 mm, and more preferably about 0.5 to 1 mm. Is.
  • the longitudinal dimension of the capillary mixer is preferably 5 times or more the inner diameter dimension (or outer diameter dimension) thereof.
  • the capillary mixer 22 has a twisted spiral rod 26 inside.
  • the twisted spiral rod 26 in the present embodiment is not limited to such a shape, and may have another shape as long as the liquid can be mixed inside the capillary mixer 22.
  • the capillary mixer 22 in FIG. 1 has a linear elongated shape in the longitudinal direction, the effect of the present invention can be exhibited even if, for example, the capillary mixer 22 includes a curved shape that is bent in the middle in the longitudinal direction. You can
  • the mixing chamber 24 has a substantially cylindrical shape, and has a space inside which a liquid can flow and stay for a predetermined time.
  • the mixing chamber 24 in this embodiment has a substantially cylindrical shape, it may have another shape such as a conical shape, a shape combining a conical shape and a cylindrical shape, or a spherical shape.
  • the mixing chamber 24 has a volume that is at least larger than that of the capillary mixer 22.
  • the mixing chamber 24 preferably has a volume 1.2 times or more that of the capillary mixer 22, more preferably 2 times or more the volume of the capillary mixer 22, and further preferably 5 times. It is preferable to have a volume more than double. Furthermore, it is preferable that the mixing chamber 24 has a shape expanded with respect to the elongated cylindrical capillary mixer 22.
  • the capillary mixer 22 and the mixing chamber 24 are linearly connected, but, for example, as shown in FIG. 3, the connecting portion between the capillary mixer 22 and the mixing chamber 24 is bent upward or in another direction.
  • the connecting portion (the portion where the liquid flows into the mixing chamber 24) has a predetermined angle.
  • the portion where the liquid flows out from the mixing chamber 24 can have a structure having a predetermined angle.
  • the second turbulent flow diffusion mixer section 30 includes a capillary mixer 32 that mixes two or more kinds of liquids by a turbulent flow with a twisted spiral rod 36 provided inside, and a liquid that is positioned downstream of the capillary mixer 32 and flows into the inside. And a mixing chamber 34 that mixes by diffusion.
  • the first turbulent diffusion mixer section 20 and the second turbulent diffusion mixer section 30 may have the same capacity, or the first turbulent diffusion mixer section 20 and the second turbulent diffusion mixer section 20 having different capacities.
  • the two-turbulent diffusion mixer section 30 may be connected in series.
  • the capacity of the first turbulent diffusion mixer section 20 is larger than the capacity of the second turbulent diffusion mixer section 30. Further, the capacity of the first turbulent diffusion mixer section 20 can be made smaller than the capacity of the second turbulent diffusion mixer section 30.
  • the fluid outlet 16 allows the liquid mixed efficiently by passing through the first turbulent diffusion mixer section 20 and the second turbulent diffusion mixer section 30 of the liquid mixing unit 14 to flow out of the static mixer 10. It is provided for.
  • a detector or the like connected in the subsequent stage can be used as a connection port for connecting to the static mixer 10.
  • liquids from the outside are introduced from the liquid inflow port 12, pass through the liquid mixing unit 14 (the first turbulent flow diffusion mixer section 20 and the second turbulent flow diffusion mixer section 30), and are mixed.
  • the liquid is then discharged to the outside via the liquid outlet 16.
  • the static mixer 10 according to this embodiment is configured as described above. Hereinafter, the liquid mixing mechanism in the present embodiment will be described in detail.
  • the liquid mixing unit 14 mixes two or more kinds of liquids.
  • the flow of the liquid inside the liquid mixing unit 14 will be described.
  • two or more kinds of liquids that have flowed in from the liquid inlet 12 reach the capillary mixer 22 included in the first turbulent flow diffusion mixer section 20.
  • the capillary mixer 22 in this embodiment is a substantially cylindrical elongated pipe or the like, and has a twisted spiral rod 26 inside the elongated pipe.
  • the torsion spiral rod 26 is, for example, a rod-shaped stainless steel having a spiral stirring member (see FIG. 2), and the liquid introduced from the liquid inlet 12 passes through the inside of the capillary mixer 22 to generate a turbulent flow. More than one type of liquid is mixed (called primary mixing).
  • the turbulent flow in this specification refers to a flow in which the velocity and pressure of the liquid fluctuate irregularly.
  • the torsion spiral rod 26 in the present embodiment is located in the entire longitudinal direction inside the capillary mixer 22, but for example, it is provided only in a part of the longitudinal direction, or the short torsion spiral rod 26. It is also possible to provide one or more places. Further, the torsion spiral rod 26 may be fixed inside the capillary mixer, or may be provided so that the torsion spiral rod itself can move to some extent inside.
  • the liquid that has been primarily mixed by turbulent flow inside the capillary mixer 22 flows into the mixing chamber 24 located in the subsequent stage.
  • the mixing chamber 24 has a substantially cylindrical shape, and has a space inside which the liquid can flow and stay for a predetermined time.
  • the liquid that is primarily mixed in the capillary mixer 22 is further promoted in the mixing chamber 24 by a diffusion action or a turbulent flow diffusion action (referred to as secondary mixing).
  • Diffusion in this specification means that two or more different types of liquids try to be mixed uniformly.
  • the turbulent flow diffusion in the present embodiment means that the liquid flows into the mixing chamber 24 from the capillary mixer 22 so that the flow velocity of the liquid is slowed, that is, the flow path of the liquid is widened and the flow is disturbed. Means that a mixing effect occurs.
  • the first turbulent flow diffusion mixer section 20 of the present embodiment two or more kinds of liquids are primarily mixed by the turbulent flow by the capillary mixer 22, and in the subsequent stage, the secondary liquid is further diffused by the mixing chamber 24 or turbulent flow diffusion.
  • the first turbulent flow diffusion mixer section 20 included in the liquid mixing unit 14 in the present embodiment improves the mixing efficiency by performing the stepwise mixing.
  • the liquid mixing unit 14 in the present embodiment is provided with a second turbulent flow diffusion mixer section 30 at a stage subsequent to the first turbulent flow diffusion mixer section 20.
  • the second turbulent flow diffusion mixer section 30 may be the same as the first turbulent flow diffusion mixer section 20 as described above, or may have a different shape and capacity.
  • the first turbulent diffusion mixer section 20 and the second turbulent diffusion mixer section 30 are directly connected, but for example, the first turbulent diffusion mixer section 20 and the second turbulent diffusion mixer section 30 are connected. It is also possible to provide a liquid channel or the like (for example, a pipe or the like) for appropriately connecting and.
  • the mixing chamber 24 in the first turbulent flow diffusion mixer section 20 can also be expected to utilize the internal space of the mixing chamber 24 to further promote the turbulent flow by the capillary mixer 22 in the preceding stage.
  • the flow of the liquid mixed to some extent by the turbulent flow by the capillary mixer 22 can be irregularly changed and then sent to the second turbulent flow diffusion mixer section 30.
  • the first turbulent diffusion mixer section 20 performs stepwise mixing by the first mixing and the second mixing, and further in the subsequent stage, the second turbulent diffusion mixer section 30 is used to perform stepwise mixing.
  • the third mixing corresponding to the first mixing and the fourth mixing corresponding to the second mixing it is possible to significantly improve the mixing efficiency.
  • the static mixer 10 shown in FIG. 4 can perform stepwise mixing of three stages without adding a new component member, and as a result, the mixing efficiency can be further improved.
  • the liquid outlet 16 may be provided with a porous body 18b having a liquid rectifying effect.
  • the porous body 18b may be arranged inside the liquid outlet 16 or at the outlet of the mixing chamber 34 (on the side of the liquid outlet 16), for example.
  • the porous body 18b in the present embodiment is configured to include a material having a large number of pores.
  • a monolith structure co-continuous structure
  • a sponge structure open cell structure
  • the porous body 18b can be configured to include a metal material such as SUS316 and a polymer material such as PEEK.
  • FIG. 6 shows a schematic diagram of another configuration including a porous body in the static mixer according to this embodiment.
  • a porous body 18b liquid outlet 16
  • the liquid can be further mixed by the secondary mixing after obtaining (the mixed state by the primary mixing).
  • the liquid mixing unit 14 is provided with the first turbulent diffusion mixer section 20 and the second turbulent diffusion mixer section 30, but as shown in FIG. 7, for example, the third turbulent diffusion mixer section 40 is further provided.
  • the third turbulent diffusion mixer section 40 is further provided.
  • the characteristic structure shown in FIG. 6, that is, the porous body 18b (or the twisted spiral plate 18 shown in FIG. 4) is provided. It can also be provided on the outlet side of the turbulent diffusion mixer section (20, 30, 40).
  • FIG. 8 shows a schematic configuration diagram of a modification of the static mixer according to the embodiment of the present invention.
  • the modification shown in the figure basically has the same components as the static mixer 10 shown in FIG. 7, but in addition to the configuration of FIG. It has a switching valve 50 for switching the series connection of the mixer units (20, 30, 40).
  • each turbulent flow diffusion mixer section has a capillary mixer and a mixing chamber as in FIGS. 1 to 7.
  • the static mixer 10 includes four switching valves 50 inside the liquid mixing unit 14.
  • the switching valve 50 may be, for example, an automatic switching valve that automatically performs the switching operation, or may be a manual switching valve that manually performs the switching operation as needed.
  • the switching valve for switching the plurality of turbulent flow diffusion mixer sections (20, 30, 40) for example, the respective turbulent flow diffusion mixer sections may be connected by pipes.
  • the switching valve 50 is adjusted so that the first turbulent diffusion mixer section 20 and the second turbulent diffusion mixer section 30 are connected in series (in FIG. 8, the third turbulent diffusion mixer is shown). Part 40 is not connected).
  • the switching valve 50 in the static mixer 10 it is possible to appropriately select the necessary turbulent diffusion mixer section (20, 30, 40) according to the measurement conditions such as component analysis. Can be done.
  • the switching valve 50 it is possible to handle a wide range of analyzes with one static mixer without preparing a plurality of static mixers according to the analysis conditions.
  • the volume of the first turbulent diffusion mixer section 20 is 125 ⁇ l
  • the volume of the second turbulent diffusion mixer section 30 is 240 ⁇ l
  • the volume of the third turbulent diffusion mixer section 40 is 370 ⁇ l, in FIG. It can be used as a static mixer 10 having a capacity of 365 ⁇ l.
  • the switching valve 50 is adjusted so that the second turbulent diffusion mixer section 30 and the third turbulent diffusion mixer section 40 are connected in series to be used as the static mixer 10 having a capacity of 610 ⁇ l. be able to.
  • the switching valve 50 is adjusted so that the first turbulent diffusion mixer section 20 and the third turbulent diffusion mixer section 40 are connected in series to be used as a static mixer having a capacity of 495 ⁇ l. be able to.
  • the switching valve 50 is adjusted so that all of the first turbulent diffusion mixer section 20, the second turbulent diffusion mixer section 30, and the third turbulent diffusion mixer section 40 are connected in series to obtain 735 ⁇ l. It can be used as a static mixer having a capacity of.
  • Fig. 12 shows an image of the measurement results of the baseline fluctuation and mixed noise due to the gradient liquid transfer. As shown in the figure, it can be seen that the amount of mixed noise is the same between the dynamic mixer having the drive unit and the static mixer according to the present measurement after 5 minutes. This indicates that the static mixer has the same mixing efficiency as that of the dynamic mixer in this gradient liquid transfer.
  • the static mixer takes a shorter time to return to the base (the vertical axis strength 0 position at the start of measurement) than the dynamic mixer.
  • the static mixer according to the present embodiment has a better solvent displacing property than the dynamic mixer having the power unit.
  • the static mixer according to this embodiment has excellent mixing efficiency equivalent to that of the dynamic mixer.
  • the liquid mixing unit 14 has a characteristic turbulent diffusion mixer section including a capillary mixer and a mixing chamber located at the subsequent stage, and at least two turbulent diffusion mixers are provided. By connecting the parts in series, the mixing efficiency can be significantly improved as compared with the conventional case.
  • the switching operation of the three turbulent diffusion mixer sections (20, 30, 40) is performed by using the four switching valves.
  • Each turbulent flow diffusion mixer section may be connected to one switching valve so that the capacity of the liquid mixing unit 14 can be switched.
  • the case where two and three turbulent diffusion mixer sections are connected in series has been described. Can be expected to get.
  • the capillary mixer and the mixing chamber are described as separate configurations, but for example, the capillary mixer and the mixing chamber can be integrally manufactured. With such a configuration, it is possible to eliminate the leakage of the liquid and obtain the turbulent diffusion mixer section having high pressure resistance. As a result, it is possible to provide a static mixer having good mixing efficiency and excellent durability.
  • the switching valve is used to perform the switching operation of the turbulent diffusion mixer section.
  • the first turbulent diffusion mixer section 20 and the second turbulent diffusion mixer section are used.
  • each turbulence diffusion mixer unit is arbitrarily selected and connected using a connecting member such as a pipe (20, Even if the static mixer 10 is configured by arbitrarily combining 30 and 40), the same effect as the modification of the present invention can be obtained.

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  • Accessories For Mixers (AREA)

Abstract

The present invention pertains to improving the mixing efficiency in a static mixer for mixing two or more types of liquids.　The present invention provides a static mixer 10 comprising: a liquid inlet 12 through which two or more types of liquids flow in; a liquid mixing unit 14 for mixing the two or more types of liquids, the liquid mixing unit 14 being connected to the post stage of the liquid inlet 12; and a liquid outlet 16 through which the mixed liquid flows out, the liquid outlet 16 being connected to the post stage of the liquid mixing unit 14. The liquid mixing unit 14 has a turbulent diffusion mixer unit 20 configured so as to include: a substantially cylindrical, long and thin capillary mixer 22, in which the liquids are mixed by turbulence by means of a twisting spiral rod 26 provided therein; and a mixing chamber 24 positioned on the post stage of the capillary mixer 22, the mixing chamber 24 mixing, in the interior thereof, the liquid that flows in. The liquid mixing unit 14 is furthermore characterized in that at least two turbulent diffusion mixer units 20, 30 are serially connected.

Description

スタティックミキサーStatic mixer 関連出願Related application
　本出願は、２０１９年１月１７日付け出願の日本国特許出願２０１９－００５７９３号の優先権を主張しており、ここに折り込まれるものである。 This application claims the priority of Japanese Patent Application No. 2019-005793 filed on January 17, 2019, and is incorporated here.
　本発明は液体を混合するためのミキサー、特に２種類以上の液体を混合するスタティックミキサーにおける混合効率の向上に関する。 The present invention relates to improvement of mixing efficiency in a mixer for mixing liquids, particularly in a static mixer for mixing two or more kinds of liquids.
　従来から、液体クロマトグラフィーなどの各種分析分野において液体を混合するためにスタティックミキサーが利用されている。このスタティックミキサーにはさまざまな種類のものがあり、その用途に合わせて多様な工夫がなされている。特に、昨今では混合する液体等の種類もさまざまであり、ミキサーとしてこれらの液体等に対応できるようにするとともに混合効率を上げるためにいろいろな工夫がなされている。 Traditionally, static mixers have been used to mix liquids in various analytical fields such as liquid chromatography. There are various types of static mixers, and various innovations have been made according to their use. In particular, recently, there are various kinds of liquids and the like to be mixed, and various devises have been made in order to be able to cope with these liquids and the like as a mixer and to increase the mixing efficiency.
　例えば特許文献１には、パイプの円柱状内部空間の横断面を２つに分割して２本の流路を形成するように捻り羽根エレメントを配置し、この捻り羽根エレメントに形成した前記２本の流路のうちの一方の流路を流れる液状体の一部がもう一方の流路へ流入するように孔を設けることで、撹拌作用をより向上させるとともに撹拌対象である液状体の適用範囲が広く、圧力損失が小さい流体撹拌装置（スタティックミキサー）に関する技術が開示されている。 For example, in Patent Document 1, a cross section of a cylindrical internal space of a pipe is divided into two, and a twisting blade element is arranged so as to form two flow paths, and the two twisting blade elements are formed. By providing holes so that a part of the liquid material flowing in one of the flow paths of the above flows into the other flow path, the stirring action is further improved and the application range of the liquid material to be stirred , A technique for a fluid agitator (static mixer) having a wide pressure drop and a small pressure loss is disclosed.
　また、特許文献２には、配管内部において複数個のバルブ（ボールバルブまたはバタフライバルブ）を半開状態で直列に配置し、隣接するバルブのバルブ軸心線周りの位相が異なるように設定することで、通過した液体等の乱流化を促進させて十分な混合を実現できる流体混合装置に関する技術が開示されている。 Further, in Patent Document 2, a plurality of valves (ball valves or butterfly valves) are arranged in series in a half-open state inside a pipe, and adjacent valves are set to have different phases around the valve axis. , A technique relating to a fluid mixing apparatus capable of promoting turbulent flow of a liquid or the like that has passed therethrough and realizing sufficient mixing.
特開２００５－３４７５０号公報Japanese Patent Laid-Open No. 2005-34750 特開２０１１－８３７６３号公報JP, 2011-83763, A
　しかしながら、特許文献１に開示されている構造であれば捻り羽根エレメントの所定位置に孔を設けるという従来のスタティックミキサーの構造に簡単な工夫を加えることで撹拌作用を向上させることができるが、あくまでも従来の機構により混合するものであり、混合効率が大きく向上するとは言えない。 However, with the structure disclosed in Patent Document 1, the stirring action can be improved by adding a simple device to the structure of the conventional static mixer in which a hole is provided at a predetermined position of the twisting blade element. Since the mixing is performed by the conventional mechanism, it cannot be said that the mixing efficiency is significantly improved.
　同様に、特許文献２のように複数個のバルブを直列配置することで乱流化を促進させて十分な混合を実現できるが、このような特有の構造であってもやはり従来の方法と同様であるため混合効率を格段に向上させることは非常に困難であり、まだまだ改良の余地がある。 Similarly, as in Patent Document 2, by arranging a plurality of valves in series, turbulence can be promoted and sufficient mixing can be realized. However, even with such a peculiar structure, it is still the same as the conventional method. Therefore, it is extremely difficult to significantly improve the mixing efficiency, and there is still room for improvement.
　本発明は上記従来技術の課題に鑑みて行われたものであって、その目的は従来のスタティックミキサーと比較して混合効率を向上させるとともに、さらに動力部を有するダイナミックミキサーと比較しても遜色のない混合効率を有するスタティックミキサーを提供することである。 The present invention has been made in view of the above-mentioned problems of the prior art, and its object is to improve mixing efficiency as compared with a conventional static mixer, and to compare with a dynamic mixer having a power unit. It is to provide a static mixer having a mixing efficiency without.
　上記課題を解決するために、本発明にかかるスタティックミキサーは、
　２種類以上の液体が流入する液体流入口と、該液体流入口の後段に接続され前記２種類以上の液体を混合する液体混合ユニットと、該液体混合ユニットの後段に接続され混合された液体が流出する液体流出口と、を備えたスタティックミキサーであって、
　前記液体混合ユニットは、内部に備える捻り螺旋棒で前記液体を乱流により混合する略円筒形状の細長いキャピラリーミキサーと、該キャピラリーミキサーの後段に位置し流れ込んだ液体を内部で混合するミキシングチャンバーと、を含んで構成された乱流拡散ミキサー部を有し、
　前記ミキシングチャンバーは、少なくとも前記キャピラリーミキサーよりも大きい体積を有し、
　さらに前記液体混合ユニットは、少なくとも２つの乱流拡散ミキサー部が直列に接続されていることを特徴とする。 In order to solve the above problems, the static mixer according to the present invention,
A liquid inflow port into which two or more kinds of liquids flow, a liquid mixing unit connected to a rear stage of the liquid inflow and mixing the two or more kinds of liquids, and a liquid connected to a rear stage of the liquid mixing unit and mixed. A static mixer having a liquid outlet that flows out,
The liquid mixing unit is a substantially cylindrical elongated capillary mixer that mixes the liquid by a turbulent flow with a twisted spiral rod provided inside, and a mixing chamber that is located at a subsequent stage of the capillary mixer and that mixes the liquid that has flowed in inside. Has a turbulent diffusion mixer section configured to include,
The mixing chamber has at least a larger volume than the capillary mixer,
Further, the liquid mixing unit is characterized in that at least two turbulent diffusion mixer sections are connected in series.
　また、本発明にかかるスタティックミキサーは、
　前記液体混合ユニットは、前記液体流入口側に位置する第１乱流拡散ミキサー部と、該第１乱流拡散ミキサー部よりも前記液体流出口側に位置する第２乱流拡散ミキサー部と、を有し、
　前記第１乱流拡散ミキサー部の液体容量は前記第２乱流拡散ミキサー部の液体容量よりも大きいことを特徴とする。 Further, the static mixer according to the present invention,
The liquid mixing unit includes a first turbulent diffusion mixer section located on the liquid inlet side, and a second turbulent diffusion mixer section located on the liquid outlet side with respect to the first turbulent diffusion mixer section. Have
The liquid volume of the first turbulent diffusion mixer section is larger than the liquid volume of the second turbulent diffusion mixer section.
　また、本発明にかかるスタティックミキサーは、
　前記液体混合ユニットは、前記液体流入口側に位置する第１乱流拡散ミキサー部と、該第１乱流拡散ミキサー部よりも前記液体流出口側に位置する第２乱流拡散ミキサー部と、を有し、
　前記第１乱流拡散ミキサー部の液体容量は前記第２乱流拡散ミキサー部の液体容量と略同一であることを特徴とする。 Further, the static mixer according to the present invention,
The liquid mixing unit includes a first turbulent diffusion mixer section located on the liquid inlet side, and a second turbulent diffusion mixer section located on the liquid outlet side with respect to the first turbulent diffusion mixer section. Have
The liquid volume of the first turbulent diffusion mixer section is substantially the same as the liquid volume of the second turbulent diffusion mixer section.
　また、本発明にかかるスタティックミキサーは、
　前記液体混合ユニットは、前記液体流入口側に位置する第１乱流拡散ミキサー部と、該第１乱流拡散ミキサー部よりも前記液体流出口側に位置する第２乱流拡散ミキサー部と、を有し、
　前記第１乱流拡散ミキサー部の液体容量は前記第２乱流拡散ミキサー部の液体容量よりも小さいことを特徴とする。 Further, the static mixer according to the present invention,
The liquid mixing unit includes a first turbulent diffusion mixer section located on the liquid inlet side, and a second turbulent diffusion mixer section located on the liquid outlet side with respect to the first turbulent diffusion mixer section. Have
The liquid volume of the first turbulent diffusion mixer section is smaller than the liquid volume of the second turbulent diffusion mixer section.
　また、本発明にかかるスタティックミキサーは、
　前記液体混合ユニットは、前記液体流入口側に位置する第１乱流拡散ミキサー部と、該第１乱流拡散ミキサー部よりも前記液体流出口側に位置する第２乱流拡散ミキサー部と、を有し、
　さらに前記液体混合ユニットは、前記第２乱流拡散ミキサー部よりも前記液体流出口側に位置する第３乱流拡散ミキサー部を備えることを特徴とする。 Further, the static mixer according to the present invention,
The liquid mixing unit includes a first turbulent diffusion mixer section located on the liquid inlet side, and a second turbulent diffusion mixer section located on the liquid outlet side with respect to the first turbulent diffusion mixer section. Have
Further, the liquid mixing unit includes a third turbulent flow diffusion mixer section located closer to the liquid outlet than the second turbulent flow diffusion mixer section.
　また、本発明にかかるスタティックミキサーは、
　前記液体出口部はその内部に捻り螺旋板を備え、該捻り螺旋板により前記液体混合ユニットで混合された液体をさらに混合して当該スタティックミキサーの外部に液体を流出することを特徴とする。 Further, the static mixer according to the present invention,
The liquid outlet part may be provided with a twisted spiral plate therein, and the twisted spiral plate may further mix the liquid mixed in the liquid mixing unit to flow the liquid out of the static mixer.
　また、本発明にかかるスタティックミキサーは、
　当該スタティックミキサーは、複数の液体混合ユニットにおける直列接続を切り替える切替バルブ機構を有し、前記切替バルブ機構の切り替え動作により液体混合ユニットの液体容量が可変されることを特徴とする。 Further, the static mixer according to the present invention,
The static mixer has a switching valve mechanism that switches series connection in a plurality of liquid mixing units, and the liquid volume of the liquid mixing unit is variable by the switching operation of the switching valve mechanism.
　また、本発明にかかるスタティックミキサーは、
　当該スタティックミキサーは、少なくとも２つの乱流拡散ミキサー部同士を配管接続することで液体混合ユニットの液体容量が可変されることを特徴とする。 Further, the static mixer according to the present invention,
The static mixer is characterized in that the liquid volume of the liquid mixing unit is variable by connecting at least two turbulent flow diffusion mixer parts to each other by piping.
　本発明によれば、液体混合ユニットはキャピラリーミキサーとその後段に位置するミキシングチャンバーを備えた特徴的な乱流拡散ミキサー部を有し、少なくとも２つの乱流拡散ミキサー部が直列に接続されることで、従来よりも混合効率が大幅に向上したスタティックミキサーを提供できる効果を奏する。 According to the present invention, the liquid mixing unit has a characteristic turbulent diffusion mixer section having a capillary mixer and a mixing chamber located at the subsequent stage, and at least two turbulent diffusion mixer sections are connected in series. Thus, it is possible to provide a static mixer in which the mixing efficiency is significantly improved as compared with the conventional one.
本発明の実施形態に係るスタティックミキサーの概略構成図を示す。The schematic block diagram of the static mixer which concerns on embodiment of this invention is shown. 本発明の本実施形態に係るキャピラリーミキサーおよび捻り螺旋棒のイメージ写真を示す。The image photograph of the capillary mixer and the twist spiral rod which concern on this embodiment of this invention is shown. 本発明の実施形態に係るスタティックミキサーにおいて、キャピラリーミキサーとミキシングチャンバーとの接続部分が角度を有する構造の概略図を示す。FIG. 3 is a schematic view of a structure in which a connecting portion between a capillary mixer and a mixing chamber has an angle in the static mixer according to the embodiment of the present invention. 本発明の実施形態に係るスタティックミキサーにおいて液体流出口に捻り螺旋板を備えた場合の概略図を示す。FIG. 3 is a schematic view of a static mixer according to an embodiment of the present invention in which a twisted spiral plate is provided at a liquid outlet. 本発明の実施形態に係るスタティックミキサーにおいて液体流出口に多孔質体を備えた場合の概略図を示す。FIG. 3 is a schematic view of a static mixer according to an embodiment of the present invention in which a liquid outlet has a porous body. 本実施形態に係るスタティックミキサーにおいて多孔質体を備えた別の構成の概略図を示す。The schematic diagram of another structure provided with the porous body in the static mixer which concerns on this embodiment is shown. 本発明の実施形態に係るスタティックミキサーにおいて３個の乱流拡散ミキサー部を直列に接続した場合の概略構成図を示す。FIG. 3 is a schematic configuration diagram in the case where three turbulent diffusion mixer sections are connected in series in the static mixer according to the embodiment of the present invention. 本発明の実施形態に係るスタティックミキサーにおける変形例の概略構成図を示す。The schematic block diagram of the modification in the static mixer which concerns on embodiment of this invention is shown. 本発明の実施形態に係るスタティックミキサーにおける変形例の概略構成図を示す。The schematic block diagram of the modification in the static mixer which concerns on embodiment of this invention is shown. 本発明の実施形態に係るスタティックミキサーにおける変形例の概略構成図を示す。The schematic block diagram of the modification in the static mixer which concerns on embodiment of this invention is shown. 本発明の実施形態に係るスタティックミキサーにおける変形例の概略構成図を示す。The schematic block diagram of the modification in the static mixer which concerns on embodiment of this invention is shown. グラジエント送液によるベースライン変動およびノイズの測定結果イメージ図を示す。The image figure of the measurement result of the baseline fluctuation and noise by gradient liquid sending is shown.
１０　　　　スタティックミキサー
１２　　　　液体流入口
１４　　　　液体混合ユニット
１６　　　　液体流出口
１８　　　　捻り螺旋板
１８ｂ　　　多孔質体
２０　　　　第１乱流拡散ミキサー部
２２　　　　キャピラリーミキサー
２４　　　　ミキシングチャンバー
２６　　　　捻り螺旋棒
３０　　　　第２乱流拡散ミキサー部
３２　　　　キャピラリーミキサー
３４　　　　ミキシングチャンバー
３６　　　　捻り螺旋棒
４０　　　　第３乱流拡散ミキサー部
５０　　　　切替バルブ 10 Static Mixer 12 Liquid Inlet 14 Liquid Mixing Unit 16 Liquid Outlet 18 Twisting Spiral Plate 18b Porous Body 20 First Turbulent Diffusion Mixer Part 22 Capillary Mixer 24 Mixing Chamber 26 Twisting Helical Rod 30 Second Turbulent Diffusion Mixer Part 32 Capillary mixer 34 Mixing chamber 36 Twisting spiral rod 40 Third turbulent flow diffusion mixer section 50 Switching valve
　以下、本発明のスタティックミキサーについて図面を用いて説明するが、本発明の趣旨を超えない限り何ら以下の例に限定されるものではない。 Hereinafter, the static mixer of the present invention will be described with reference to the drawings, but the present invention is not limited to the following examples as long as the gist of the present invention is not exceeded.
　図１に本発明の実施形態に係るスタティックミキサーの概略構成図を示す。同図に示すスタティックミキサー１０は、２種類以上の液体が流入する液体流入口１２と、該液体流入口１２の後段に接続され前記２種類以上の液体を混合する液体混合ユニット１４と、該液体混合ユニット１４の後段に接続され混合された液体が流出する液体流出口１６と、を備えて構成されている。 FIG. 1 shows a schematic configuration diagram of a static mixer according to an embodiment of the present invention. The static mixer 10 shown in the figure includes a liquid inlet 12 into which two or more kinds of liquids flow, a liquid mixing unit 14 connected to a subsequent stage of the liquid inlet 12 to mix the two or more kinds of liquids, and the liquid. And a liquid outlet 16 which is connected to the subsequent stage of the mixing unit 14 and through which the mixed liquid flows out.
　液体流入口１２は、外部からの液体を当該スタティックミキサー１０へ流入させるために設けられている。液体流入口１２には、例えば２つ以上の液体タンクおよび液体タンクから液体流入口１２までの液体流路が接続されている（図示を省略）。液体タンクにはそれぞれ別の種類の液体が入っており、すなわち、液体流入口１２には当該スタティックミキサー１０の外部から２種類以上の液体が流入されることとなる。 The liquid inlet 12 is provided to allow the liquid from the outside to flow into the static mixer 10. For example, two or more liquid tanks and a liquid flow path from the liquid tank to the liquid inlet 12 are connected to the liquid inlet 12 (not shown). The liquid tanks contain different kinds of liquids, that is, two or more kinds of liquids flow into the liquid inlet 12 from the outside of the static mixer 10.
　液体混合ユニット１４は、前記液体流入口１２側に位置する第１乱流拡散ミキサー部２０と、該第１乱流拡散ミキサー部２０よりも前記液体流出口１６側に位置する第２乱流拡散ミキサー部３０とが直列に接続されている。本実施形態ではこの特徴的な構造を有する第１乱流拡散ミキサー部２０および第２乱流拡散ミキサー部３０を利用して２種類以上の液体が効率良く混合されることとなる。 The liquid mixing unit 14 includes a first turbulent diffusion mixer section 20 located on the liquid inlet 12 side and a second turbulent diffusion section located on the liquid outlet 16 side with respect to the first turbulent diffusion mixer section 20. The mixer unit 30 is connected in series. In this embodiment, two or more kinds of liquids are efficiently mixed by utilizing the first turbulent flow diffusion mixer section 20 and the second turbulent flow diffusion mixer section 30 having this characteristic structure.
　第１乱流拡散ミキサー部２０は、内部に備える捻り螺旋棒２６で２種類以上の液体を乱流により混合するキャピラリーミキサー２２と、該キャピラリーミキサー２２の後段に位置し流れ込んだ液体を内部での拡散により混合するミキシングチャンバー２４と、を含んで構成されている。 The first turbulent flow diffusion mixer section 20 includes a capillary mixer 22 that mixes two or more kinds of liquids by a turbulent flow with a twisted spiral rod 26 provided inside, and a liquid that is positioned downstream of the capillary mixer 22 and flows into the inside. And a mixing chamber 24 for mixing by diffusion.
　キャピラリーミキサー２２は、ステンレス、ＰＥＥＫ（ポリエーテルエーテルケトン）、ＰＴＦＥ（ポリテトラフルオロエチレン）などを含んだ略円筒形状の細長い配管（パイプ）等で構成されている。キャピラリーミキサー２２は、その内径がおよそ０．２５～３ｍｍ程度であることが好ましく、特に好ましくは０．５～２ｍｍ程度であることが好ましく、より好ましくは０．５～１ｍｍ程度であることが好適である。また、キャピラリーミキサーの長手寸法は、その内径寸法（または外径寸法）の５倍以上であることが好ましい。 The capillary mixer 22 is composed of a substantially cylindrical elongated pipe containing stainless steel, PEEK (polyether ether ketone), PTFE (polytetrafluoroethylene), and the like. The inner diameter of the capillary mixer 22 is preferably about 0.25 to 3 mm, particularly preferably about 0.5 to 2 mm, and more preferably about 0.5 to 1 mm. Is. The longitudinal dimension of the capillary mixer is preferably 5 times or more the inner diameter dimension (or outer diameter dimension) thereof.
　本実施形態では図２のイメージ写真に示すようにキャピラリーミキサー２２の内部に捻り螺旋棒２６を有して構成されている。また、本実施形態における捻り螺旋棒２６はこのような形状に限られずキャピラリーミキサー２２内部で液体を混合できれば他の形状であっても良い。また、図１におけるキャピラリーミキサー２２は長手方向に直線の細長い形状を有しているが、例えばキャピラリーミキサー２２の長手方向において途中から曲がった曲線形状を含んでいても本発明の効果を発揮することができる。 In this embodiment, as shown in the image photograph of FIG. 2, the capillary mixer 22 has a twisted spiral rod 26 inside. Further, the twisted spiral rod 26 in the present embodiment is not limited to such a shape, and may have another shape as long as the liquid can be mixed inside the capillary mixer 22. Further, although the capillary mixer 22 in FIG. 1 has a linear elongated shape in the longitudinal direction, the effect of the present invention can be exhibited even if, for example, the capillary mixer 22 includes a curved shape that is bent in the middle in the longitudinal direction. You can
　ミキシングチャンバー２４は略円筒形状を有しており、内部には液体が流入して所定時間留まることができる空間を有している。本実施形態におけるミキシングチャンバー２４は略円筒形状であるが、例えば円錐形状、円錐形状と円筒形状を組み合わせた形状、球状など他の形状でも構わない。 The mixing chamber 24 has a substantially cylindrical shape, and has a space inside which a liquid can flow and stay for a predetermined time. Although the mixing chamber 24 in this embodiment has a substantially cylindrical shape, it may have another shape such as a conical shape, a shape combining a conical shape and a cylindrical shape, or a spherical shape.
　また、ミキシングチャンバー２４は、少なくともキャピラリーミキサー２２よりも大きい体積を有して構成されている。ミキシングチャンバー２４は、キャピラリーミキサー２２の１．２倍以上の体積を有していることが好ましく、より好ましくはキャピラリーミキサー２２の２倍以上の体積を有していることが好ましく、さらに好ましくは５倍以上の体積を有していることが好適である。さらにミキシングチャンバー２４は、略円筒形状の細長いキャピラリーミキサー２２に対して拡幅した形状を有していることが好ましい。 The mixing chamber 24 has a volume that is at least larger than that of the capillary mixer 22. The mixing chamber 24 preferably has a volume 1.2 times or more that of the capillary mixer 22, more preferably 2 times or more the volume of the capillary mixer 22, and further preferably 5 times. It is preferable to have a volume more than double. Furthermore, it is preferable that the mixing chamber 24 has a shape expanded with respect to the elongated cylindrical capillary mixer 22.
　図１では、キャピラリーミキサー２２とミキシングチャンバー２４は直線的に接続されているが、例えば図３に示すように、キャピラリーミキサー２２とミキシングチャンバー２４との接続部分が上方向や他の方向に曲げられている構造、すなわち当該接続部分（液体がミキシングチャンバー２４に流入する部分）が所定の角度を有する構造にすることも出来る。また、図示を省略しているがミキシングチャンバー２４から液体が流出する部分についても所定の角度を有する構造にすることが出来る。 In FIG. 1, the capillary mixer 22 and the mixing chamber 24 are linearly connected, but, for example, as shown in FIG. 3, the connecting portion between the capillary mixer 22 and the mixing chamber 24 is bent upward or in another direction. Alternatively, the connecting portion (the portion where the liquid flows into the mixing chamber 24) has a predetermined angle. Further, although not shown, the portion where the liquid flows out from the mixing chamber 24 can have a structure having a predetermined angle.
　同様に第２乱流拡散ミキサー部３０は、内部に備える捻り螺旋棒３６で２種類以上の液体を乱流により混合するキャピラリーミキサー３２と、該キャピラリーミキサー３２の後段に位置し流れ込んだ液体を内部での拡散により混合するミキシングチャンバー３４と、を含んで構成されている。 Similarly, the second turbulent flow diffusion mixer section 30 includes a capillary mixer 32 that mixes two or more kinds of liquids by a turbulent flow with a twisted spiral rod 36 provided inside, and a liquid that is positioned downstream of the capillary mixer 32 and flows into the inside. And a mixing chamber 34 that mixes by diffusion.
　本実施形態において、第１乱流拡散ミキサー部２０および第２乱流拡散ミキサー部３０は同じ容量を有するものであっても良いし、あるいはそれぞれ容量の異なる第１乱流拡散ミキサー部２０と第２乱流拡散ミキサー部３０とを直列に接続するようにしても良い。本実施形態に係るスタティックミキサー１０では、第１乱流拡散ミキサー部２０の容量が第２乱流拡散ミキサー部３０の容量よりも大きい。また、第１乱流拡散ミキサー部２０の容量は第２乱流拡散ミキサー部３０の容量よりも小さくすることも出来る。 In the present embodiment, the first turbulent diffusion mixer section 20 and the second turbulent diffusion mixer section 30 may have the same capacity, or the first turbulent diffusion mixer section 20 and the second turbulent diffusion mixer section 20 having different capacities. The two-turbulent diffusion mixer section 30 may be connected in series. In the static mixer 10 according to this embodiment, the capacity of the first turbulent diffusion mixer section 20 is larger than the capacity of the second turbulent diffusion mixer section 30. Further, the capacity of the first turbulent diffusion mixer section 20 can be made smaller than the capacity of the second turbulent diffusion mixer section 30.
　流体流出口１６は、液体混合ユニット１４が有する第１乱流拡散ミキサー部２０および第２乱流拡散ミキサー部３０を通過することで効率良く混合された液体を当該スタティックミキサー１０の外部に流出させるために設けられている。例えば成分分析においては、後段に接続される検出器等を当該スタティックミキサー１０に接続するための接続口として利用することができる。 The fluid outlet 16 allows the liquid mixed efficiently by passing through the first turbulent diffusion mixer section 20 and the second turbulent diffusion mixer section 30 of the liquid mixing unit 14 to flow out of the static mixer 10. It is provided for. For example, in component analysis, a detector or the like connected in the subsequent stage can be used as a connection port for connecting to the static mixer 10.
　このように、外部からの２種類以上の液体は、液体流入口１２から流入され、液体混合ユニット１４（第１乱流拡散ミキサー部２０および第２乱流拡散ミキサー部３０）を通過して混合され、その後に液体流出口１６を経由して外部に流出される。本実施形態に係るスタティックミキサー１０は、概略以上のように構成されている。以下、本実施形態における液体の混合メカニズムについて詳しく説明する。 Thus, two or more kinds of liquids from the outside are introduced from the liquid inflow port 12, pass through the liquid mixing unit 14 (the first turbulent flow diffusion mixer section 20 and the second turbulent flow diffusion mixer section 30), and are mixed. The liquid is then discharged to the outside via the liquid outlet 16. The static mixer 10 according to this embodiment is configured as described above. Hereinafter, the liquid mixing mechanism in the present embodiment will be described in detail.
液体の混合について
　上記説明のとおり本実施形態に係るスタティックミキサー１０は、液体混合ユニット１４で２種類以上の液体を混合している。ここでは、液体混合ユニット１４の内部における液体の流れについて説明する。まず、液体流入口１２から流入した２種類以上の液体は第１乱流拡散ミキサー部２０が有するキャピラリーミキサー２２へと到達する。 Regarding Mixing of Liquid As described above, in the static mixer 10 according to this embodiment, the liquid mixing unit 14 mixes two or more kinds of liquids. Here, the flow of the liquid inside the liquid mixing unit 14 will be described. First, two or more kinds of liquids that have flowed in from the liquid inlet 12 reach the capillary mixer 22 included in the first turbulent flow diffusion mixer section 20.
　本実施形態におけるキャピラリーミキサー２２は略円筒形状の細長い配管等であり、且つ、細長い配管の内部に捻り螺旋棒２６を有して構成されている。捻り螺旋棒２６は例えば螺旋状の撹拌部材を有する棒状のステンレスなどであり（図２を参照）、液体流入口１２から流入された液体がキャピラリーミキサー２２内部を通過することによる乱流作用で２種類以上の液体が混合される（１次混合と呼ぶ）。ここで、本明細書における乱流とは液体の速度や圧力などが不規則に変動する流れのことを言う。 The capillary mixer 22 in this embodiment is a substantially cylindrical elongated pipe or the like, and has a twisted spiral rod 26 inside the elongated pipe. The torsion spiral rod 26 is, for example, a rod-shaped stainless steel having a spiral stirring member (see FIG. 2), and the liquid introduced from the liquid inlet 12 passes through the inside of the capillary mixer 22 to generate a turbulent flow. More than one type of liquid is mixed (called primary mixing). Here, the turbulent flow in this specification refers to a flow in which the velocity and pressure of the liquid fluctuate irregularly.
　また図１に示すように本実施形態における捻り螺旋棒２６は、キャピラリーミキサー２２内部の長手方向全体に位置しているが、例えば、長手方向の一部にのみ設けたり、あるいは短い捻り螺旋棒２６を１カ所ないし２カ所以上設けることもできる。さらに捻り螺旋棒２６はキャピラリーミキサー内部に固定されていても良いし、内部である程度捻り螺旋棒自体が動けるように設けても良い。 Further, as shown in FIG. 1, the torsion spiral rod 26 in the present embodiment is located in the entire longitudinal direction inside the capillary mixer 22, but for example, it is provided only in a part of the longitudinal direction, or the short torsion spiral rod 26. It is also possible to provide one or more places. Further, the torsion spiral rod 26 may be fixed inside the capillary mixer, or may be provided so that the torsion spiral rod itself can move to some extent inside.
　キャピラリーミキサー２２内部で乱流により１次混合された液体は、後段に位置するミキシングチャンバー２４へと流入される。上述のとおりミキシングチャンバー２４は、略円筒形状を有しており、内部には液体が流入して所定時間留まることができる空間を有している。 The liquid that has been primarily mixed by turbulent flow inside the capillary mixer 22 flows into the mixing chamber 24 located in the subsequent stage. As described above, the mixing chamber 24 has a substantially cylindrical shape, and has a space inside which the liquid can flow and stay for a predetermined time.
　そしてキャピラリーミキサー２２内部で１次混合された液体は、ミキシングチャンバー２４内部で拡散作用ないし乱流拡散作用によりさらに混合が促進される（２次混合と呼ぶ）。本明細書における拡散とは、異なる２種類以上の液体が一様に混ざり合おうとすることを言う。また、本実施形態における乱流拡散とは、液体がキャピラリーミキサー２２からミキシングチャンバー２４へ流入されることで該液体の流速が遅くなり、すなわち、液体の流路が広がり、その中で流れの乱れが生じることで混合効果が発生することを意味する。 Then, the liquid that is primarily mixed in the capillary mixer 22 is further promoted in the mixing chamber 24 by a diffusion action or a turbulent flow diffusion action (referred to as secondary mixing). Diffusion in this specification means that two or more different types of liquids try to be mixed uniformly. Further, the turbulent flow diffusion in the present embodiment means that the liquid flows into the mixing chamber 24 from the capillary mixer 22 so that the flow velocity of the liquid is slowed, that is, the flow path of the liquid is widened and the flow is disturbed. Means that a mixing effect occurs.
　本実施形態における第１乱流拡散ミキサー部２０では、キャピラリーミキサー２２による乱流で２種類以上の液体を１次混合し、その後段ではミキシングチャンバー２４による拡散ないし乱流拡散でさらに液体の２次混合を行うことで、すなわち、本実施形態において液体混合ユニット１４が備える第１乱流拡散ミキサー部２０は、段階的な混合を行うことで混合効率を向上させている。 In the first turbulent flow diffusion mixer section 20 of the present embodiment, two or more kinds of liquids are primarily mixed by the turbulent flow by the capillary mixer 22, and in the subsequent stage, the secondary liquid is further diffused by the mixing chamber 24 or turbulent flow diffusion. By performing the mixing, that is, the first turbulent flow diffusion mixer section 20 included in the liquid mixing unit 14 in the present embodiment improves the mixing efficiency by performing the stepwise mixing.
　さらに本実施形態における液体混合ユニット１４は、上記第１乱流拡散ミキサー部２０の後段に第２乱流拡散ミキサー部３０が設けられている。この第２乱流拡散ミキサー部３０は、上述のとおり第１乱流拡散ミキサー部２０と同じものを利用しても良いし、あるいは異なる形状や容量のものを利用しても良い。また、本実施形態では第１乱流拡散ミキサー部２０と第２乱流拡散ミキサー部３０とを直接接続しているが、例えば第１乱流拡散ミキサー部２０と第２乱流拡散ミキサー部３０とを適切に接続するための液体流路等（例えば配管等）を設けることもできる。 Further, the liquid mixing unit 14 in the present embodiment is provided with a second turbulent flow diffusion mixer section 30 at a stage subsequent to the first turbulent flow diffusion mixer section 20. The second turbulent flow diffusion mixer section 30 may be the same as the first turbulent flow diffusion mixer section 20 as described above, or may have a different shape and capacity. Further, in the present embodiment, the first turbulent diffusion mixer section 20 and the second turbulent diffusion mixer section 30 are directly connected, but for example, the first turbulent diffusion mixer section 20 and the second turbulent diffusion mixer section 30 are connected. It is also possible to provide a liquid channel or the like (for example, a pipe or the like) for appropriately connecting and.
　この時、第１乱流拡散ミキサー部２０におけるミキシングチャンバー２４は、該ミキシングチャンバー２４の内部空間を利用して前段のキャピラリーミキサー２２による乱流をさらに促進する効果も期待できる。具体的には、キャピラリーミキサー２２による乱流である程度混合された液体の流れを不規則に変えてから、第２乱流拡散ミキサー部３０へと送ることができる。 At this time, the mixing chamber 24 in the first turbulent flow diffusion mixer section 20 can also be expected to utilize the internal space of the mixing chamber 24 to further promote the turbulent flow by the capillary mixer 22 in the preceding stage. Specifically, the flow of the liquid mixed to some extent by the turbulent flow by the capillary mixer 22 can be irregularly changed and then sent to the second turbulent flow diffusion mixer section 30.
　このように本実施形態では第１乱流拡散ミキサー部２０で第１混合および第２混合による段階的な混合を行い、さらに後段でも第２乱流拡散ミキサー部３０を利用して段階的な混合（第１混合に相当する第３混合、および第２混合に相当する第４混合）を行うことで、混合効率を格段に向上させることができる。 As described above, in the present embodiment, the first turbulent diffusion mixer section 20 performs stepwise mixing by the first mixing and the second mixing, and further in the subsequent stage, the second turbulent diffusion mixer section 30 is used to perform stepwise mixing. By performing (the third mixing corresponding to the first mixing and the fourth mixing corresponding to the second mixing), it is possible to significantly improve the mixing efficiency.
　さらに図４に示すように、液体流出口１６の内部に捻り螺旋板１８を備えることで、乱流による追加混合を行うことができる。すなわち、図４におけるスタティックミキサー１０では、新たな構成部材を追加することなく３段階もの段階的な混合ができるので、その結果、混合効率をさらに向上させることができる。 Further, as shown in FIG. 4, by providing the twist spiral plate 18 inside the liquid outlet 16, additional mixing due to turbulent flow can be performed. That is, the static mixer 10 shown in FIG. 4 can perform stepwise mixing of three stages without adding a new component member, and as a result, the mixing efficiency can be further improved.
　また、図５のように、液体流出口１６に液体の整流効果を有する多孔質体１８ｂを備えることも出来る。このような構成とすることで、当該スタティックミキサー１０から安定した混合液体をカラムや検出器等に流出させることができる。この多孔質体１８ｂは、例えば液体流出口１６の内部または、ミキシングチャンバー３４の出口（液体流出口１６側）に配置しても良い。ここで、本実施形態における多孔質体１８ｂは細孔が非常に多く空いている材料を含んで構成されている。本実施形態では、例えばモノリス構造体（共連続体）、スポンジ構造体（連続気泡構造体）、粉体の焼結体等を多孔質体１８ｂとして利用することができる。また、多孔質体１８ｂは、ＳＵＳ３１６などの金属材料やＰＥＥＫなどのポリマー材料を含んで構成することができる。 Further, as shown in FIG. 5, the liquid outlet 16 may be provided with a porous body 18b having a liquid rectifying effect. With such a configuration, a stable mixed liquid can be made to flow from the static mixer 10 to a column, a detector, or the like. The porous body 18b may be arranged inside the liquid outlet 16 or at the outlet of the mixing chamber 34 (on the side of the liquid outlet 16), for example. Here, the porous body 18b in the present embodiment is configured to include a material having a large number of pores. In this embodiment, for example, a monolith structure (co-continuous structure), a sponge structure (open cell structure), a powdered sintered body, or the like can be used as the porous body 18b. Further, the porous body 18b can be configured to include a metal material such as SUS316 and a polymer material such as PEEK.
　図６には、本実施形態に係るスタティックミキサーにおいて多孔質体を備えた別の構成の概略図を示す。同図に示すように例えば多孔質体１８ｂ（液体流出口１６）を第１乱流拡散ミキサー部２０および第２乱流拡散ミキサー部３０の両方に設けることで、１次混合による安定した混合液体（１次混合による混合状態）を得たうえでその後の２次混合によりさらに液体を混合させることができる。 FIG. 6 shows a schematic diagram of another configuration including a porous body in the static mixer according to this embodiment. As shown in the figure, for example, by providing the porous body 18b (liquid outlet 16) in both the first turbulent flow diffusion mixer section 20 and the second turbulent flow diffusion mixer section 30, a stable mixed liquid by primary mixing is provided. The liquid can be further mixed by the secondary mixing after obtaining (the mixed state by the primary mixing).
　そして、本実施形態では液体混合ユニット１４に第１乱流拡散ミキサー部２０と第２乱流拡散ミキサー部３０を備えていたが、例えば図７に示すようにさらに第３乱流拡散ミキサー部４０（第３キャピラリーミキサー４２、第３ミキシングチャンバー４４）を備えることで、混合する液体の種類や条件によってさらなる混合効率の向上が期待できる。この第３乱流拡散ミキサー部４０を備えたスタティックミキサー１０においても例えば図６に示したような特徴的な構造、すなわち多孔質体１８ｂ（または図４に示した捻り螺旋板１８）をそれぞれの乱流拡散ミキサー部（２０、３０、４０）の出口側に設けることも出来る。 Further, in the present embodiment, the liquid mixing unit 14 is provided with the first turbulent diffusion mixer section 20 and the second turbulent diffusion mixer section 30, but as shown in FIG. 7, for example, the third turbulent diffusion mixer section 40 is further provided. By providing the (third capillary mixer 42, the third mixing chamber 44), further improvement in mixing efficiency can be expected depending on the type and conditions of the liquids to be mixed. Also in the static mixer 10 including the third turbulent flow diffusion mixer section 40, for example, the characteristic structure shown in FIG. 6, that is, the porous body 18b (or the twisted spiral plate 18 shown in FIG. 4) is provided. It can also be provided on the outlet side of the turbulent diffusion mixer section (20, 30, 40).
変形例
　図８には、本発明の実施形態に係るスタティックミキサーにおける変形例の概略構成図を示す。同図に示す変形例は基本的には図７に示したスタティックミキサー１０と同じ構成部品を有しているが、図７の構成に加えて、液体混合ユニット１４の内部において複数の乱流拡散ミキサー部（２０、３０、４０）の直列接続を切り替えるための切替バルブ５０を有して構成されている。また、図８では符号を省略してあるが、当然のことながら図１ないし図７と同様にそれぞれの乱流拡散ミキサー部はキャピラリーミキサーおよびミキシングチャンバーを有して構成されている。 Modification FIG. 8 shows a schematic configuration diagram of a modification of the static mixer according to the embodiment of the present invention. The modification shown in the figure basically has the same components as the static mixer 10 shown in FIG. 7, but in addition to the configuration of FIG. It has a switching valve 50 for switching the series connection of the mixer units (20, 30, 40). Although not shown in FIG. 8, of course, each turbulent flow diffusion mixer section has a capillary mixer and a mixing chamber as in FIGS. 1 to 7.
　図８に示すように本変形例におけるスタティックミキサー１０では、液体混合ユニット１４の内部に４個の切替バルブ５０を備えている。この切替バルブ５０は例えば自動で切り替え動作を行う自動切替バルブであっても良いし、あるいは必要に応じて手動で切り替え動作を行う手動切替バルブにすることも出来る。また、複数の乱流拡散ミキサー部（２０、３０、４０）を切り替えるために切替バルブを利用せず、例えばそれぞれの乱流拡散ミキサー部同士を配管で接続するようにしても良い。 As shown in FIG. 8, the static mixer 10 according to the present modification includes four switching valves 50 inside the liquid mixing unit 14. The switching valve 50 may be, for example, an automatic switching valve that automatically performs the switching operation, or may be a manual switching valve that manually performs the switching operation as needed. Further, instead of using the switching valve for switching the plurality of turbulent flow diffusion mixer sections (20, 30, 40), for example, the respective turbulent flow diffusion mixer sections may be connected by pipes.
　図８では、切替バルブ５０を調整することで、第１乱流拡散ミキサー部２０と第２乱流拡散ミキサー部３０とを直列に接続するようにしている（図８では第３乱流拡散ミキサー部４０は接続されていない）。このように本実施形態に係るスタティックミキサー１０に切替バルブ５０を利用することで、成分分析などの測定条件に応じて必要な乱流拡散ミキサー部（２０、３０、４０）を適切に選択することが出来る。また、このような切替バルブ５０を有する構成であれば、分析条件に合わせて複数台のスタティックミキサーを用意することなく、１台のスタティックミキサーで広範囲の分析に対応することができる。 In FIG. 8, the switching valve 50 is adjusted so that the first turbulent diffusion mixer section 20 and the second turbulent diffusion mixer section 30 are connected in series (in FIG. 8, the third turbulent diffusion mixer is shown). Part 40 is not connected). In this way, by using the switching valve 50 in the static mixer 10 according to the present embodiment, it is possible to appropriately select the necessary turbulent diffusion mixer section (20, 30, 40) according to the measurement conditions such as component analysis. Can be done. Further, with such a configuration having the switching valve 50, it is possible to handle a wide range of analyzes with one static mixer without preparing a plurality of static mixers according to the analysis conditions.
　例えば、第１乱流拡散ミキサー部２０の容量を１２５μｌ、第２乱流拡散ミキサー部３０の容量を２４０μｌ、第３乱流拡散ミキサー部４０の容量を３７０μｌとした場合には、図８においては３６５μｌの容量を有するスタティックミキサー１０として利用することができる。 For example, when the volume of the first turbulent diffusion mixer section 20 is 125 μl, the volume of the second turbulent diffusion mixer section 30 is 240 μl, and the volume of the third turbulent diffusion mixer section 40 is 370 μl, in FIG. It can be used as a static mixer 10 having a capacity of 365 μl.
　また、図９に示すように切替バルブ５０を調整して第２乱流拡散ミキサー部３０と第３乱流拡散ミキサー部４０とを直列接続することで６１０μｌの容量を有するスタティックミキサー１０として利用することができる。同様に、図１０に示すように切替バルブ５０を調整して第１乱流拡散ミキサー部２０と第３乱流拡散ミキサー部４０とを直列接続することで４９５μｌの容量を有するスタティックミキサーとして利用することができる。 Further, as shown in FIG. 9, the switching valve 50 is adjusted so that the second turbulent diffusion mixer section 30 and the third turbulent diffusion mixer section 40 are connected in series to be used as the static mixer 10 having a capacity of 610 μl. be able to. Similarly, as shown in FIG. 10, the switching valve 50 is adjusted so that the first turbulent diffusion mixer section 20 and the third turbulent diffusion mixer section 40 are connected in series to be used as a static mixer having a capacity of 495 μl. be able to.
　さらに、図１１に示すように切替バルブ５０を調整して第１乱流拡散ミキサー部２０と第２乱流拡散ミキサー部３０と第３乱流拡散ミキサー部４０の全てを直列接続することで７３５μｌの容量を有するスタティックミキサーとして利用することが出来る。 Further, as shown in FIG. 11, the switching valve 50 is adjusted so that all of the first turbulent diffusion mixer section 20, the second turbulent diffusion mixer section 30, and the third turbulent diffusion mixer section 40 are connected in series to obtain 735 μl. It can be used as a static mixer having a capacity of.
　以下、実施例により、本発明についてさらに具体的な説明を行うが、本発明の趣旨を超えない限り何ら以下の実施例に限定させるものではない。はじめに、直列接続による混合効率の向上について確認を行った。 Hereinafter, the present invention will be described in more detail by way of examples, but the present invention is not limited to the following examples unless it exceeds the gist of the present invention. First, we confirmed the improvement of mixing efficiency by series connection.
乱流拡散ミキサー部の直列接続による混合効率の確認
　本発明に係るスタティックミキサー１０は、第１乱流拡散ミキサー部２０と第２乱流拡散ミキサー部３０を直列に接続して利用することで、良好な混合効率が得られるものである。そこで下記条件で、本発明に係るスタティックミキサー１０の混合効率の確認を行った。

・試験方法
　まず、リファレンスとしてミキサー（捻り螺旋棒２６）を有しない配管における液体の混合状態を混合ノイズ（μＶ）として測定する。次に、乱流拡散ミキサー部が１個の場合（３７０μｌ）、２個の場合（１２５μｌ＋２４０μｌ＝３６５μｌ）の各流量における混合ノイズ（μＶ）を測定した。このリファレンスに対してどれだけ混合ノイズが減少したかを低減率として表した。

・条件
　溶媒Ａ　　　　　　　　　　：２０ｍＭギ酸アンモニウム水溶液
　溶媒Ｂ　　　　　　　　　　：アセトニトリル／水（８０／２０）
　Ａ／Ｂ　　　　　　　　　　：２０／８０
　検出波長　　　　　　　　　：２２０ｎｍ
　流量　　　　　　　　　　　：０．２５、０．５、１．０ｍＬ／ｍｉｎ
　背圧チューブ　　　　　　　：Ｉ．Ｄ．０．０６４×５００ｍｍ
　ポンプ型式　　　　　　　　：ＰＵ－４１８５－Ｂ（日本分光株式会社製）
　検出器型式　　　　　　　　：ＵＶ－４０７０（日本分光株式会社製）
 Confirmation of Mixing Efficiency by Connecting Turbulent Diffusion Mixer Sections in Series By using the first turbulent diffusion mixer section 20 and the second turbulent diffusion mixer section 30 connected in series, the static mixer 10 according to the present invention is used. Good mixing efficiency can be obtained. Therefore, the mixing efficiency of the static mixer 10 according to the present invention was confirmed under the following conditions.

-Test method First, the mixed state of the liquid in the pipe which does not have a mixer (twisted spiral rod 26) as a reference is measured as mixed noise (μV). Next, the mixing noise (μV) was measured at each flow rate when the turbulent diffusion mixer section was one (370 μl) and two (125 μl+240 μl=365 μl). The reduction rate represents how much the mixed noise was reduced with respect to this reference.

-Conditions Solvent A: 20 mM ammonium formate aqueous solution Solvent B: Acetonitrile/water (80/20)
A/B: 20/80
Detection wavelength: 220nm
Flow rate: 0.25, 0.5, 1.0 mL/min
Back pressure tube: I. D. 0.064 x 500 mm
Pump model: PU-4185-B (manufactured by JASCO Corporation)
Detector model: UV-4070 (manufactured by JASCO Corporation)
［表１］
ミキサー容量　　　　　　　　　　流量別ノイズの値（μＶ）　　　　　　
　　　　　　　　　　　　０．２５　０．５　　１．０　（ｍＬ／ｍｉｎ）
リファレンス　　　　　　６５２１　３５８０　１０１９　　　　　　　　
３７０μｌ　　　　　　　　　９２　　　５２　　　６０　　　　　　　　
　　　低減率（％）　　　９８．６　９８．５　９４．１　　　　　　　　
２４０μｌ＋１２５μｌ　　　２２　　　２２　　　４８　　　　　　　　
　　　低減率（％）　　　９９．７　９９．４　９５．３　　　　　　　　
[Table 1]
Mixer capacity Noise value by flow rate (μV)
0.25 0.5 1.0 (mL/min)
Reference 6521 3580 1019
370 μl 92 52 60
Reduction rate (%) 98.6 98.5 94.1
240 μl + 125 μl 22 22 48
Reduction rate (%) 99.7 99.4 95.3
　表１に示すように０．２５、０．５、１．０ｍＬ／ｍｉｎのどの流量においても乱流拡散ミキサー部が１個の場合よりも乱流拡散ミキサー部が２個の場合のほうが混合ノイズの低減率が高いのが分かる。すなわち、同じ液体混合ユニット１４の容量を有するスタティックミキサーであれば２個の乱流拡散ミキサー部を直列に接続して利用したほうが、混合効率が良いことが分かる。 As shown in Table 1, at any flow rate of 0.25, 0.5, and 1.0 mL/min, the mixing noise is greater in the case of two turbulent diffusion mixer sections than in the case of one turbulent diffusion mixer section. It can be seen that the reduction rate of is high. That is, if the static mixer has the same capacity of the liquid mixing unit 14, it is understood that the mixing efficiency is better when two turbulent flow diffusion mixer sections are connected in series and used.
ダイナミックミキサーとの比較について
　次に、本発明に係るスタティックミキサー１０と駆動部を有するダイナミックミキサーとの混合効率の比較を行った。
・試験方法
　２種類の液体でグラジエント送液を行い、ダイナミックミキサー（１．５ｍｌ）と同容量を有するスタティックミキサー（３個の乱流拡散ミキサー部を直列に接続）についてのベースライン変動およびノイズを測定した。

・測定条件
　ダイナミックミキサー容量：１．５ｍｌ
　スタティックミキサー容量：１．５６ｍｌ（５２０μｌ×３個）
　移動相Ａ　　　　：水（０．１％ＴＦＡ含有）
　移動相Ｂ　　　　：７０％アセトニトリル（０．１％ＴＦＡ含有）
　流量　　　　　　：１．０ｍｌ／ｍｉｎ
　検出波長　　　　：２２０ｎｍ、ＳＴＤレスポンス、Ｃｏｎｖｅｎｔｉｏｎａｌセル
　モジュール間配管：ミキサーまでＳＵＳ　０．２５ｍｍ　Ｉ．Ｄ．
　　　　　　　　　　ミキサー以降ＰＥＥＫ　０．２５ｍｍ　Ｉ．Ｄ．

・グラジエント条件
時間［ｍｉｎ］　　　　機能　　Ｌ（Ａ）側　　Ｒ（Ｂ）側　　　
　　０．００　　　　組成比　　　１００％　　　　　０％　　　
　１５．００　　　　組成比　　　　　０％　　　１００％　　　
　２０．００　　　　組成比　　　　　０％　　　１００％　　　
　２５．００　　　　組成比　　　１００％　　　　　０％　　　
　３５．００　　　　組成比　　　１００％　　　　　０％　　　
 Comparison with Dynamic Mixer Next, the mixing efficiency of the static mixer 10 according to the present invention and the dynamic mixer having a driving unit was compared.
・Test method Gradient transfer was performed with two kinds of liquids, and the baseline fluctuation and noise of a static mixer (three turbulent diffusion mixer sections connected in series) having the same capacity as the dynamic mixer (1.5 ml) were measured. It was measured.

・Measurement conditions Dynamic mixer capacity: 1.5 ml
Static mixer capacity: 1.56 ml (520 μl x 3)
Mobile phase A: Water (containing 0.1% TFA)
Mobile phase B: 70% acetonitrile (containing 0.1% TFA)
Flow rate: 1.0 ml/min
Detection wavelength: 220 nm, STD response, Conventional cell Piping between modules: Mixer SUS 0.25 mm I.D. D.
After mixer PEEK 0.25 mm I.D. D.

・Gradient conditions
Time [min] Function L(A) side R(B) side
0.00 Composition ratio 100% 0%
15.00 Composition ratio 0% 100%
20.00 Composition ratio 0% 100%
25.00 Composition ratio 100% 0%
35.00 Composition ratio 100% 0%
　図１２に上記グラジエント送液によるベースライン変動および混合ノイズの測定結果イメージ図を示す。同図に示すように、駆動部を有するダイナミックミキサーと本測定によるスタティックミキサーとでは５分経過時において混合ノイズ量が同等であることが分かる。これは本グラジエント送液においてスタティックミキサーはダイナミックミキサーと同等の混合効率であることを表している。 Fig. 12 shows an image of the measurement results of the baseline fluctuation and mixed noise due to the gradient liquid transfer. As shown in the figure, it can be seen that the amount of mixed noise is the same between the dynamic mixer having the drive unit and the static mixer according to the present measurement after 5 minutes. This indicates that the static mixer has the same mixing efficiency as that of the dynamic mixer in this gradient liquid transfer.
　また、３０分ないし３５分経過時においてダイナミックミキサーよりもスタティックミキサーのほうがベース（測定開始時の縦軸強度０位置）に戻るまでの時間が早いのが分かる。これは、動力部を有するダイナミックミキサーと比較して本実施形態に係るスタティックミキサーのほうが溶媒の置換性が良いことを示している。このように、本実施形態におけるスタティックミキサーは、ダイナミックミキサーと同等の優れた混合効率を有していることが分かった。 Also, it can be seen that after 30 minutes to 35 minutes, the static mixer takes a shorter time to return to the base (the vertical axis strength 0 position at the start of measurement) than the dynamic mixer. This indicates that the static mixer according to the present embodiment has a better solvent displacing property than the dynamic mixer having the power unit. As described above, it was found that the static mixer according to this embodiment has excellent mixing efficiency equivalent to that of the dynamic mixer.
　以上のように本発明に係るスタティックミキサー１０は、液体混合ユニット１４がキャピラリーミキサーとその後段に位置するミキシングチャンバーを備えた特徴的な乱流拡散ミキサー部を有し、少なくとも２つの乱流拡散ミキサー部が直列に接続されることで、従来よりも混合効率を大幅に向上させることができる。 As described above, in the static mixer 10 according to the present invention, the liquid mixing unit 14 has a characteristic turbulent diffusion mixer section including a capillary mixer and a mixing chamber located at the subsequent stage, and at least two turbulent diffusion mixers are provided. By connecting the parts in series, the mixing efficiency can be significantly improved as compared with the conventional case.
　さらに、本実施形態に係るスタティックミキサー１０における変形例では、４個の切替バルブを利用して３個の乱流拡散ミキサー部（２０、３０、４０）の切替動作を行っているが、例えば、１個の切替バルブにそれぞれの乱流拡散ミキサー部を接続して液体混合ユニット１４の容量を切り替えられるようにしても良い。そして本実施形態では乱流拡散ミキサー部の直列接続について２個および３個の場合を説明したが、これらの個数に限られず４個以上の乱流拡散ミキサー部を直列接続しても同様の効果を得ることが期待できる。 Further, in the modification example of the static mixer 10 according to the present embodiment, the switching operation of the three turbulent diffusion mixer sections (20, 30, 40) is performed by using the four switching valves. Each turbulent flow diffusion mixer section may be connected to one switching valve so that the capacity of the liquid mixing unit 14 can be switched. In the present embodiment, the case where two and three turbulent diffusion mixer sections are connected in series has been described. Can be expected to get.
　また、本実施形態ではキャピラリーミキサーとミキシングチャンバーをそれぞれ別々の構成として説明しているが、例えばキャピラリーミキサーとミキシングチャンバーとを一体として製造することも出来る。このような構成とすることで、液体の漏れを解消し、耐圧に強い乱流拡散ミキサー部を得ることができる。その結果、混合効率が良く、耐久性の優れたスタティックミキサーを提供することができる。 In addition, in the present embodiment, the capillary mixer and the mixing chamber are described as separate configurations, but for example, the capillary mixer and the mixing chamber can be integrally manufactured. With such a configuration, it is possible to eliminate the leakage of the liquid and obtain the turbulent diffusion mixer section having high pressure resistance. As a result, it is possible to provide a static mixer having good mixing efficiency and excellent durability.
　そして本実施形態における変形例（図８～図１１）では、切替バルブを利用して乱流拡散ミキサー部の切替動作を行っているが、例えば、第１乱流拡散ミキサー部２０と第２乱流拡散ミキサー部３０（および第３乱流拡散ミキサー部４０）とを接続する際に、配管等の接続部材を利用してそれぞれの乱流拡散ミキサー部を任意に選択して接続する（２０、３０、４０を任意に組み合わせる）ことでスタティックミキサー１０を構成しても本発明の変形例と同様の効果を得ることが出来る。 In the modified example (FIGS. 8 to 11) of this embodiment, the switching valve is used to perform the switching operation of the turbulent diffusion mixer section. However, for example, the first turbulent diffusion mixer section 20 and the second turbulent diffusion mixer section are used. When connecting to the flow diffusion mixer unit 30 (and the third turbulent flow diffusion mixer unit 40), each turbulence diffusion mixer unit is arbitrarily selected and connected using a connecting member such as a pipe (20, Even if the static mixer 10 is configured by arbitrarily combining 30 and 40), the same effect as the modification of the present invention can be obtained.

Claims (8)

  1. 　２種類以上の液体が流入する液体流入口と、該液体流入口の後段に接続され前記２種類以上の液体を混合する液体混合ユニットと、該液体混合ユニットの後段に接続され混合された液体が流出する液体流出口と、を備えたスタティックミキサーであって、
    　前記液体混合ユニットは、内部に備える捻り螺旋棒で前記液体を乱流により混合する略円筒形状の細長いキャピラリーミキサーと、該キャピラリーミキサーの後段に位置し流れ込んだ液体を内部で混合するミキシングチャンバーと、を含んで構成された乱流拡散ミキサー部を有し、
    　前記ミキシングチャンバーは、少なくとも前記キャピラリーミキサーよりも大きい体積を有し、
    　さらに前記液体混合ユニットは、少なくとも２つの乱流拡散ミキサー部が直列に接続されていることを特徴とするスタティックミキサー。     A liquid inflow port into which two or more kinds of liquids flow, a liquid mixing unit connected to a rear stage of the liquid inflow and mixing the two or more kinds of liquids, and a liquid connected to a rear stage of the liquid mixing unit and mixed. A static mixer having a liquid outlet that flows out,
    The liquid mixing unit is a substantially cylindrical elongated capillary mixer that mixes the liquid by a turbulent flow with a twisted spiral rod provided inside, and a mixing chamber that is located at a subsequent stage of the capillary mixer and that mixes the liquid that has flowed in inside. Has a turbulent diffusion mixer section configured to include,
    The mixing chamber has at least a larger volume than the capillary mixer,
    Further, the liquid mixing unit is characterized in that at least two turbulent diffusion mixer sections are connected in series.
  2. 　請求項１に記載のスタティックミキサーであって、
    　前記液体混合ユニットは、前記液体流入口側に位置する第１乱流拡散ミキサー部と、該第１乱流拡散ミキサー部よりも前記液体流出口側に位置する第２乱流拡散ミキサー部と、を有し、
    　前記第１乱流拡散ミキサー部の液体容量は前記第２乱流拡散ミキサー部の液体容量よりも大きいことを特徴とするスタティックミキサー。     The static mixer according to claim 1, wherein
    The liquid mixing unit includes a first turbulent diffusion mixer section located on the liquid inlet side, and a second turbulent diffusion mixer section located on the liquid outlet side with respect to the first turbulent diffusion mixer section. Have
    The static mixer according to claim 1, wherein a liquid volume of the first turbulent diffusion mixer section is larger than a liquid volume of the second turbulent diffusion mixer section.
  3. 　請求項１に記載のスタティックミキサーであって、
    　前記液体混合ユニットは、前記液体流入口側に位置する第１乱流拡散ミキサー部と、該第１乱流拡散ミキサー部よりも前記液体流出口側に位置する第２乱流拡散ミキサー部と、を有し、
    　前記第１乱流拡散ミキサー部の液体容量は前記第２乱流拡散ミキサー部の液体容量と略同一であることを特徴とするスタティックミキサー。     The static mixer according to claim 1, wherein
    The liquid mixing unit includes a first turbulent diffusion mixer section located on the liquid inlet side, and a second turbulent diffusion mixer section located on the liquid outlet side with respect to the first turbulent diffusion mixer section. Have
    The static mixer, wherein the liquid volume of the first turbulent diffusion mixer section is substantially the same as the liquid volume of the second turbulent diffusion mixer section.
  4. 　請求項１に記載のスタティックミキサーであって、
    　前記液体混合ユニットは、前記液体流入口側に位置する第１乱流拡散ミキサー部と、該第１乱流拡散ミキサー部よりも前記液体流出口側に位置する第２乱流拡散ミキサー部と、を有し、
    　前記第１乱流拡散ミキサー部の液体容量は前記第２乱流拡散ミキサー部の液体容量よりも小さいことを特徴とするスタティックミキサー。     The static mixer according to claim 1, wherein
    The liquid mixing unit includes a first turbulent diffusion mixer section located on the liquid inlet side, and a second turbulent diffusion mixer section located on the liquid outlet side with respect to the first turbulent diffusion mixer section. Have
    The static mixer according to claim 1, wherein a liquid volume of the first turbulent diffusion mixer section is smaller than a liquid volume of the second turbulent diffusion mixer section.
  5. 　請求項１ないし請求項４のいずれかに記載のスタティックミキサーであって、
    　前記液体混合ユニットは、前記液体流入口側に位置する第１乱流拡散ミキサー部と、該第１乱流拡散ミキサー部よりも前記液体流出口側に位置する第２乱流拡散ミキサー部と、を有し、
    　さらに前記液体混合ユニットは、前記第２乱流拡散ミキサー部よりも前記液体流出口側に位置する第３乱流拡散ミキサー部を備えることを特徴とするスタティックミキサー。     The static mixer according to any one of claims 1 to 4,
    The liquid mixing unit includes a first turbulent diffusion mixer section located on the liquid inlet side, and a second turbulent diffusion mixer section located on the liquid outlet side with respect to the first turbulent diffusion mixer section. Have
    Furthermore, the said liquid mixing unit is equipped with the 3rd turbulent diffusion mixer part located in the said liquid outflow side rather than the said 2nd turbulent diffusion mixer part, The static mixer characterized by the above-mentioned.
  6. 　請求項１ないし請求項５のいずれかに記載のスタティックミキサーであって、
    　前記液体出口部はその内部に捻り螺旋板を備え、該捻り螺旋板により前記液体混合ユニットで混合された液体をさらに混合して当該スタティックミキサーの外部に液体を流出することを特徴とするスタティックミキサー。     The static mixer according to any one of claims 1 to 5,
    The liquid outlet part is provided with a twist spiral plate therein, and the twist spiral plate further mixes the liquid mixed in the liquid mixing unit to flow the liquid out of the static mixer. ..
  7. 　請求項１ないし請求項６のいずれかに記載のスタティックミキサーであって、
    　当該スタティックミキサーは、複数の液体混合ユニットにおける直列接続を切り替える切替バルブ機構を有し、
    　前記切替バルブ機構の切り替え動作により液体混合ユニットの液体容量が可変されることを特徴とするスタティックミキサー。     The static mixer according to any one of claims 1 to 6,
    The static mixer has a switching valve mechanism that switches series connection in a plurality of liquid mixing units,
    A static mixer, wherein the liquid volume of the liquid mixing unit is variable by the switching operation of the switching valve mechanism.
  8. 　請求項１ないし請求項６のいずれかに記載のスタティックミキサーであって、
    　当該スタティックミキサーは、少なくとも２つの乱流拡散ミキサー部同士を配管接続することで液体混合ユニットの液体容量が可変されることを特徴とするスタティックミキサー。     The static mixer according to any one of claims 1 to 6,
    The static mixer is characterized in that the liquid volume of the liquid mixing unit is variable by connecting at least two turbulent flow diffusion mixer parts to each other by piping.
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