WO2020146178A1 - Régulation du flux sanguin - Google Patents

Régulation du flux sanguin Download PDF

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Publication number
WO2020146178A1
WO2020146178A1 PCT/US2020/000003 US2020000003W WO2020146178A1 WO 2020146178 A1 WO2020146178 A1 WO 2020146178A1 US 2020000003 W US2020000003 W US 2020000003W WO 2020146178 A1 WO2020146178 A1 WO 2020146178A1
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WO
WIPO (PCT)
Prior art keywords
blood flow
controlling
tubing
blood
flexible tubing
Prior art date
Application number
PCT/US2020/000003
Other languages
English (en)
Inventor
Jean I MONTAGU
William Bell
Herman Deweerd
Original Assignee
Montagu Jean I
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Montagu Jean I filed Critical Montagu Jean I
Publication of WO2020146178A1 publication Critical patent/WO2020146178A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/15003—Source of blood for venous or arterial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150221—Valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150946—Means for varying, regulating, indicating or limiting the speed or time of blood collection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
    • A61B5/154—Devices using pre-evacuated means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/155—Devices specially adapted for continuous or multiple sampling, e.g. at predetermined intervals

Definitions

  • the present invention relates to a device and method for controlling fluid flow and, more particularly, a device and method for reducing blood flow during blood collection or blood filtration.
  • Phlebotomy procedures are often carried out using a blood collection device known as a“blood collection set.”
  • a typical blood collection set includes a needle assembly having at the front end a needle to be inserted into a vein to draw blood, having at the terminal (collection) end a similar but different needle intended to penetrate the rubber-like stopper of a collection tube, and a thin flexible plastic connecting tube of resilient material about 12 inches long that connects the two needles.
  • the needle at the collection end is frequently attached to a tube“guide” that is open at one end to receive and guide the evacuated collection tube so that the needle is properly aligned while penetrating the tube’s stopper.
  • the blood collection procedure may start with installing the guide to the terminal needle prior to inserting the frontal needle into the targeted blood vein.
  • An evacuated collection tube is inserted into the open end of the tube guide so that the terminal end of the needle pierces the stopper of the evacuated tube.
  • the vein of the patient is placed in communication with the interior of the evacuated tube, and the pressure differential between the blood vessel and the evacuated tube will generate a flow of blood through the front needle, the flexible tubing, the terminal needle, and finally into the evacuated tube.
  • US Patent 9,427,707 hereby incorporated by reference as is fully reproduced herein, discloses a blood collection technique and a separation technique, where the plasma and serum are separated in a specially designed collection and separation tube.
  • the separation tube is connected to a blood collection set.
  • the flow of blood into the collection tube cannot greatly exceed the flow of blood within the filter material contained within.
  • the blood flow into the separation tube is too high, there is a rapid buildup of the pressure difference across the filter inside the separation tube.
  • An excessive pressure difference across the filter creates excessive shear forces on the red blood cells resulting in fracturing of the red blood cells.
  • the resulting hemolysis makes the filtered sample unusable in many applications.
  • the excessive pressure difference, and thus the damaging over-pressure is most likely to occur at the beginning of the blood filtering process, where the filter material is usually penetrated only a millimeter or two, and offers the least resistance to the blood flow.
  • the over-pressure can be avoided by limiting the average inflow rate to a value only slightly greater than the initial flow rate within the filter.
  • a standard evacuated tube is connected to a blood collection set.
  • a blood collection set When the needle is inserted, there is an instantaneous application of a sudden high vacuum to the patient's blood vessel. This strong force can lead to the vessel’s wall collapsing against the bevel of the needle resulting in blood flow stoppage.
  • the present invention relates a device for controlling fluid flow.
  • the various disclosed devices are designed to reduce a flow inside a tubing for medical applications, such as during blood collection or blood filtration.
  • the device acts to slow down the average flow rate of blood flowing into a blood collection container, a pre-evacuated blood collection tube, or a blood filtering device, for example.
  • the flow control / reducer device reduces a flow rate inside resilient tubing using a closed/opened concept of flow regulation (or in another embodiment a partially closed/opened concept of flow regulation), which concept can be easily adapted to a digital control method, or a mechanically constructed method to cause a predetermined average flow rate of blood from a vein into an evacuated collection tube, or a blood filtering device, for example.
  • slowing down the average blood flow rate has numerous advantages such as preventing red blood cell damage when blood enters a fibrous filter located within an evacuated plasma/serum collecting device. Slowing down the average blood flow rate also reduces flow rate during a venous blood collection in manner that avoids the collapse of a patient's blood vein during the blood collection process.
  • the flow reducer device is used with a commercially available, sterile blood collection set, wherein an externally coupled device is free of contact with the collected blood, and is reusable with replacement collection sets.
  • the flow reducer device may be used with the blood collection set and the standard evacuated collection tube, or the separation tube / device described in US Patent 9,427,707, wherein in all cases the externally coupled device is free of contact with the collected blood, and is reusable with replacement blood collection sets.
  • the flow reducer minimizes red cell damage in a plasma/serum evacuated collection tube. It functions with a fluid transfer device for transferring fluid from a patient to an evacuated collection device.
  • the fluid transfer device is preferably a typical blood collection set, for example, a“Safety-Lock” product commercially available from Becton, Dickinson and Company that incorporates a length of flexible plastic tubing having resilient walls, e.g. of plasticized PVC.
  • the flow reducer device is a small, hand-held, self-contained, battery-operated unit, for example, powered by a
  • the flow reducer device may include a retention unit into which the tubing of the“Blood Collection Set” is inserted and which periodically imparts a force on the outer surface of the tubing to obstruct passage through the tubing at intervals, thus reducing the average flow rate to desired levels.
  • the flow control device is suitable for various commercially available sterile blood collection sets.
  • the flow control device is an externally coupled device that is free of contact with the collected blood, and is reusable with
  • the flow control device includes a compression mechanism to briefly totally obstruct flow (or briefly partially obstruct flow) of blood through tubing in a periodic manner (or non-periodic manner using a selected algorithm) to establish a much-reduced average flow rate into an evacuated collection tube (or container) including a filter to reduce hemolysis, as described in detail in US Patent 9,427,707.
  • the flow control device reduces blood flow to prevent the collapse of a patient's blood vein that may occur when an evacuated blood collection device is used.
  • the fluid transfer device is preferably a typical blood collection set such as a“Safety-Lock” product commercially available from Becton, Dickinson and Company that incorporates a length of flexible plastic tubing.
  • the flow control device delivers blood at a predetermined reduced average rate of flow using commercially available needle sets by the application of forces on the exterior of the tubing, thus preserving sterility.
  • the flow control device produces the necessary forces by means of a small, convenient, reusable device that can be quickly attached directly to the exterior of the tubing (or detached from the exterior of the tubing) of a commercial “Blood Collection Set,” or an equivalent set, or a similar set.
  • the flow control device uses of a cam-and-follower
  • the flow control device is constructed to obstruct fully in a periodic manner the flexible tubing of a blood collection set, where the elasticity of the tubing and pressure of the fluid permits fluid passage again when action is
  • the flow control device is constructed to obstruct partially, in a periodic manner, the flexible tubing of a blood collection set, where the elasticity of the tubing and pressure of the fluid permits full fluid passage when obstruction is terminated.
  • the flow control device is constructed to obstruct fully and next obstruct partially, in a periodic manner, the flexible tubing of a blood collection set, where the elasticity of the tubing and pressure of the fluid permits fluid passage when obstruction is terminated.
  • the partial obstruction may provide for a capillary flow of blood inside the flexible tubing.
  • the flow control device is a hand-held unit constructed to obstruct in a periodic manner the flexible tubing of a blood collection set clamped to it with the added feature that the clamping is arranged to initiate the tubing obstruction action.
  • the initial clamping partially compresses the resilient tubing therefore restraining its motion and reduces the needed motion of a pin to close the tubing.
  • the flow control device is a hand-held device supported on the tubing and powered by a battery because its construction requires only a small amount of the energy for operate the device.
  • embodiments of the hand held device consume less than 370 mW, when controlling the blood flow, and more preferably, embodiments less than 100 mW when controlling the blood flow. The design thus allows a longer battery life.
  • a preferred embodiment of the flow control device uses a linear motion driver-and-pin construction to fully obstruct in a periodic manner the flexible tubing of a standard“blood collection set”.
  • the device uses a motor-driven cam-and-follower pin to fully obstruct in a periodic manner the flexible tubing of a blood collection set, where the resiliency of the tubing and pressure of the fluid open the passage to permit fluid flow when obstruction is terminated.
  • a device for controlling fluid flow, including blood flow, inside a tubing includes a retention unit, a restriction unit, a control unit, and a power unit.
  • the retention unit is constructed to enclose a resilient portion of a flexible tubing.
  • the restriction unit is constructed to act on the enclosed portion of the flexible tubing to alter blood flow inside the flexible tubing.
  • the control unit operates cooperatively with the restriction unit and is designed to control blood flow inside the flexible tubing.
  • the power unit provides electrical power.
  • control unit is designed to control the blood flow inside the flexible tubing by periodically fully interrupting the blood flow and then permitting fully the blood flow inside the flexible tubing.
  • control unit is designed to control the blood flow inside the flexible tubing by periodically interrupting the blood flow partially and then permitting fully the blood flow inside the flexible tubing.
  • partially interrupting the blood flow may include creating capillary flow of blood or fluid inside the flexible tubing.
  • the control unit controls the restriction unit to reduce average of the blood flow to a flow range between 30% and 1 % of an unrestricted blood flow inside the tubing.
  • the control unit controls the restriction unit to reduce average of the blood flow to a flow range between 50% and 3% of an unrestricted blood flow inside the tubing.
  • the control unit controls the restriction unit to reduce average of the blood flow to a flow range between 20% and 3% of an unrestricted blood flow inside the tubing.
  • the control unit controls the restriction unit to reduce average of the blood flow to a flow range between 15% and 5% of an unrestricted blood flow inside the tubing.
  • the control unit controls the restriction unit to reduce average of said blood flow to a flow range of about 10% of an unrestricted blood flow inside the tubing.
  • the flow reduction device may control blood flow, wherein the tubing connects a blood source and a collection tube being at different pressure levels and wherein the control unit limits the rate of change of a pressure difference between the blood source and the collection tube.
  • the device may be designed to cause a speedy transition from open flow to closed flow such as to stimulate a condition known as“water hammering” that induces a backward flow in the incoming stream and consequently pushes the vein tissue away from the needle in the vein during blood drawing.
  • the device may be designed to enhance the“water hammering’ condition by having a secondary tube pinching (as shown in FIG. 8) occurring upstream from the primary tube closing in order to magnify the backflow condition.
  • the hand-held flow reduction device is designed to minimize the energy required for operation and thus allowing longer battery life.
  • the device may be constructed to obstruct in a periodic manner the flexible tubing of a blood collection set clamped to it with the added feature that the clamping is arranged to initiate the tubing obstruction action.
  • the initial clamping partially compresses the tubing therefore restraining its motion and reduces the needed motion of a pin to close the tubing.
  • the use of a use of a linear motion driver-and-pin construction fully obstructs (or partially obstructs, in another embodiment) the flexible tubing of a“Blood Collection Set”.
  • the motor-driven cam- and-follower pin obstructs the flexible tubing of a blood collection set where the resiliency of the tubing and pressure of the fluid open the passage to permit fluid flow when obstruction is terminated.
  • the flow reduction device may control blood flow using the control unit controls the restriction unit to reduce average of the blood flow based on a specific algorithm by obstructing and by permitting the flow inside the tubing.
  • the flow reduction device may control blood flow in a tubing delivering blood drawn from a living being to a blood collection container, and wherein the control unit limits increase in the pressure differential rate of change of the blood flow inside the tubing.
  • the device may alternatively control blood flow in the tubing delivering blood drawn from a living being to a pre-evacuated container, and wherein the control unit limits increase in the pressure differential rate of change of the blood flow inside the tubing.
  • the blood collection container may be pre-evacuated to different pressure levels.
  • the flow reduction device may control blood flow in a tubing delivering blood drawn from a living being to the plasma / serum separation device, described in US Patent 9,427,707, which is incorporated by reference, and wherein the control unit limits increase in the pressure differential rate of change of the blood flow inside the tubing delivering blood.
  • the device may even reduce for some time the blood flow to a capillary flow.
  • control unit controls the restriction unit that includes an anvil and a periodically driven pin designed to control the blood flow and having an internal power source consuming less than 370 mW when controlling the blood flow. More preferably, the control unit controls the restriction unit that includes an anvil and a periodically driven pin designed to control the blood flow and having an internal power source consuming less than 100 mW when controlling the blood flow.
  • control unit controls the restriction unit that includes a rotating cam driving a shuttle ram constructed for controllably compressing the tubing against an anvil thereby controlling the blood flow.
  • restriction unit includes a linear motion driver acting as shuttle ram for compressing and releasing the resilient tubing against an anvil thereby controlling the blood flow.
  • the flow control / flow reduction device is constructed as a handheld unit attachable to the tubing by employing the retention unit.
  • the device powered by an incorporated rechargeable battery and a charging circuitry.
  • the device includes a photovoltaic cell connected to charge the rechargeable battery.
  • the device controls flow including a blood flow in the tubing, wherein the tubing is delivering blood drawn from a living being to a pre-evacuated container, and the pre-evacuated container includes a filter located within the container for filtering blood to obtain plasma or serum substantially free of hemolysis
  • the flow reduction device that is convenient to use, easily learned, easily assimilated to and minimally disruptive to current operating practices of medical treatments, and maximally compatible with widely used components.
  • FIG. 1 is a diagrammatic representation of a flow control device designed to control flow inside a tubing included with a standard blood collection set providing blood to an evacuated blood collection tube or container, or providing blood to a plasma / serum separation container.
  • FIG. 2 is a conceptual presentation of the flow control device, shown in FIG. 1 , acting on the tubing of a standard blood collection set.
  • FIG. 2A is a diagram of the instantaneous blood flow and the resulting average flow rate of blood flowing into the evacuated collection tube or into the plasma / serum separation tube, shown in FIG. 1 , via the standard blood collection set.
  • FIG. 2B is a graph of the resulting blood flow rate of blood flowing as a function of pressure for different embodiments of the flow control / reducer device.
  • FIG. 3 illustrates a standard / conventional blood collection set and the plasma / serum separation device.
  • FIG. 4 is a perspective and exploded view of the flow control device acting on the standard blood collection set providing blood to the plasma / serum separation device.
  • FIG. 5 is a perspective of the flow control device, shown in FIG. 4, with the plasma / serum separation device attached via a guide of the standard blood collection set.
  • FIG. 6 is another enlarged view of the flow control device, shown in FIG. 5, without the plasma / serum separation device.
  • FIG. 7 illustrates three cam designs for three different flow rates of the flow control device, shown in FIG. 6, using a linear motor/cam-and-follower unit.
  • FIG. 8 illustrates another embodiment of the device shown in FIG. 1 , including a restriction unit having a two cam construction.
  • FIG. 8A illustrates a relative timing diagram for the device shown in FIG. 8.
  • FIGs. 1 and 2 illustrate a device 10 for controlling blood flow (or any fluid flow) inside a flexible, resilient tubing 100.
  • Flow control device 10 includes a retention unit 20, a restriction unit 30, a control unit 40, and a power unit 50 providing electrical power.
  • Retention unit 20 is illustrated by a clamp backing 106 shown in FIG. 1 and is illustrated by a chassis and a fixed part of a clamp 120.
  • Restriction unit 30 includes a cam-and-follower unit driven by a motor 103, driving a cam 104 acting on a clamping pin 105. Clamping pin 105 compresses resilient tubing 100 and thus reduces flow or completely interrupts flow inside resilient tubing 100.
  • FIG. 2 diagrammatically illustrates flow control device 10 controlling fluid flow from a fluid reservoir 130, located at a higher pressure, to a fluid reservoir 140, located at a lower pressure.
  • Fluid reservoir 130 is a representation of a blood vessel in a human arm
  • fluid reservoir 140 is a representation of a plasma / serum separation tube 200, shown in FIG. 1.
  • Control unit 40 includes a linear motor or a rotational motor with a motor coupling providing a reciprocating of a clamping pin 105.
  • FIG. 7 shows three different cam designs for use with motor 103, shown in FIG. 1.
  • Power unit 50 includes a rechargeable battery 102 and recharge controller receiving standard 110V electrical power via connection 108. Alternatively, power unit 50 includes a non-rechargeable battery.
  • FIG. 1 illustrates a single lobe cam 104 driven by a DC geared motor 103, the associated control circuitry 101 and a battery 102.
  • DC geared motor 103 consumes less than 370 mW, and even less than 100 mW, when controlling the blood flow.
  • pin 105 compresses resilient tubing 100 at selected time intervals, due to its linear action, and completely interrupts the blood flow inside the tubing for a selected duration.
  • FIG. 2A graphically illustrates the pinching effect of flow control device 10 controlling blood flow.
  • FIG. 2A shows the instantaneous flow when tubing 100 is open as well as the average flow rate as experienced inside blood filtering tube 200.
  • FIG. 2A graphically illustrates blood flow when cam 301 (FIG. 7) is used.
  • FIG. 2B is a graph of the resulting blood flow rate of blood flowing as a function of pressure for different embodiments of the flow reducer device, using a one lobe cam and two lobe cam, as shown in FIG. 7.
  • FIG. 3 illustrates a standard / conventional blood collection set such as BD Vacutainer Safety-LOKTM Blood Collection Set.
  • FIG. 3 also illustrates the plasma / serum separation tube 200, which is described in detail in US Patent 9,427,707, hereby incorporated by reference as is fully reproduced herein.
  • the standard blood collection set includes a butterfly needle coupled to flexible, resilient tubing 100, which is coupled to a needle for insertion into an inlet septum of the evacuated collection tube, or of the plasma / serum separation tube 200.
  • An insertion guide 201 is used for safety reasons to guide the insertion needle for safe and convenient coupling of couple tubing 100 and the insertion needle with tube 200.
  • flow control / flow reducer device 10 removably attaches to flexible tubing 100.
  • a clamp 204 secures tubing 100 in the correct position in a guide channel forming an anvil, as shown also in FIG. 6.
  • flow control device 10 is attached to and fully supported by tubing 100.
  • FIG. 3 is a sterile single-use, disposable set.
  • Flow control device 10 is externally attachable to tubing 100, from one set to another, without effecting the sterility of the tubing or the sterility of the set, when drawing and transferring blood or any another fluid.
  • FIG. 5 also illustrates the size of flow control device 10 with respect to an adult’s hand.
  • device 10 has a length of less than 70 mm and weighs less than 40 grams.
  • flow control device 10 is attached to insertion guide 201 of the standard blood set such as the BD Vacutainer Safety- LOKTM blood collection needle set.
  • a phlebotomist inserts the butterfly needle into a vein of a donor.
  • Tube 100 is placed and attached to the hand-held flow control device 10 by rotating the clamp/anvil (204) over the tubing (100) to firmly hold it.
  • DC geared motor 103 shown in FIG. 6
  • a user depresses a start button 202 (shown in FIG. 4).
  • Flow control device 10 is disconnected from tubing 100 of the set.
  • the blood set is normally discarded along with insertion guide 201.
  • Flow control device 10 may be reused indefinitely since it has not been contaminated by contact with the blood samples.
  • cam modulation method The benefit of a cam modulation method is that the average flow rate is defined by the cam geometry and can accept a wide range of rotational variation. Speed variation of DC motor 103 energized with a battery 102 will not affect the flow rate output even when variation of the battery output voltage may occur. The flow reduction is defined by the geometry of the cam 104. A number of cam options are shown on FIG. 7 indicating conceptual flow rate ratios.
  • Cams 301 , 301 A, 301 B deliver a flow rate 1 Q
  • Cam 302 delivers a flow rate 2Q
  • cam 303 a flow rate 1.5Q when operating in the same environment.
  • device 10 or 10A uses the motor/cam-and- follower design that depends on the duration of the open fluid flow period as a fraction of the duration of the flow interrupted. This is determined by the fraction of lesser diameter of the cam to the larger diameter of the cam that activates the clamping pin 105, shown in FIG. 2, or clamping pins 105A and 105B, shown in FIG.
  • Motor 103 drives the cam that pushes the clamping pin held in a linear bearing (linear bearing 150 shown in FIG. 2).
  • a rotation speed of 90 rpm was found to be appropriate for blood separation purposes when the overall flow interval is in the 30 to 60 seconds range.
  • the clamp provides a continuous compression of tubing 100 of about 0.015 inch on approximately a 1/16 inch along its length, and when activated the cam moves further about 0.035 inch to close the tubing inside diameter of 0.050 inch.
  • the installed tubing has an inner cross section that approximates an oval section but this has no consequence to the blood flow.
  • the pinching effect occurs approximately 1.5 times per second and the flow is fully obstructed about 80% of the time. Opening and closing the passage is comparatively slow and occupies an additional 10% of the time, as shown in FIG. 2A. This operation results in the absence of hemolysis in the blood serum. Tubing 100 is mostly unobstructed for approximately 10% of the period.
  • the cam provides a continuous compression of tubing 100 of about 0.025 inch on approximately a 1/16 inch along segment and when activated the cam moves further about 0.025 inch to close the tubing inside diameter of 0.050 inch.
  • the installed tubing has an inner cross section approximates an oval section, but this has no consequence to the blood flow.
  • the pinching effect occurs approximately 1.5 times per second and the flow inside the tubing is fully obstructed about 85% of the time. Opening and closing the passage is comparatively slow and occupies an additional 10% of the time. This operation results in the absence of hemolysis in the blood serum, described in US Patent 9,427,707.
  • the tubing is mostly unobstructed for approximately 5% of the period.
  • the pinching of the tubing can be adjusted to yield a wide choice of permissible average flow rate in addition to the fraction of the wrap around of the cam reduction segment.
  • FIG. 8 illustrates another embodiment of the device, shown in FIG.1 , including a restriction unit having a two cam construction. This two cam embodiment includes active backflow capabilities.
  • FIG. 8A illustrates a relative timing diagram for the device shown in FIG. 8 and associated timing diagram creating a backflow“water hammering” wave.
  • a device 10A is constructed for controlling blood flow (or any fluid flow) inside a flexible, resilient tubing 100.
  • Flow control device 10A includes a retention unit, a restriction unit, a control unit, and a power unit providing electrical power.
  • the retention unit is illustrated by a clamp or an anvil 106A shown in FIG. 8 and is illustrated by a chassis and a fixed part of a clamp 120 shown in FIG 2.
  • the restriction unit includes a two cam design, including cam 104A and cam 104B (i.e. , cam 1 and cam 2 shown in FIG. 8).
  • a motor 103A rotates a shaft and two bearings, driving cam 104A and cam 104B, acting respectively on a clamping pin 105A and clamping pin 105B.
  • Clamping pins 105A and 105B compress resilient tubing 100, as shown in FIG. 8A and thus reduce flow or completely interrupt flow inside resilient tubing 100.
  • cam 2 is normally opened (allows unrestricted flow) when cam 1 blokes blood flow, but shortly following a cam 1 cycle of open flow/closure, cam 2 compresses the flexible tubing in the segment closes to the needle puncture site therefore inducing a compression wave to separate vein tissue from the tip of the inserted needle. This improves the blood collection procedure,

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Abstract

Un dispositif portatif 10 permettant de réguler le flux sanguin, ou toute circulation de fluide à l'intérieur d'un tube élastique 100 souple est conçu pour faire circuler le flux sanguin. Le dispositif 10 comprend une unité de retenue 20, une unité de restriction 30, une unité de commande 40 et une unité d'alimentation 50 permettant de fournir une puissance électrique. L'unité de retenue 20 présente un support de serrage 106, un châssis et une partie fixe d'une pince 120. L'unité de restriction 30 comprend une unité de came et de suiveur entraînée par un moteur 103, entraînant une came 104 agissant sur une broche de serrage 105. La broche de serrage 105 comprime le tube élastique 100 et réduit ainsi le flux, ou interrompt complètement le flux à l'intérieur du tube élastique 100. Le dispositif de régulation de flux est supporté sur le tube et est alimenté par une batterie du fait que sa conception ne requiert qu'une petite quantité d'énergie pour le fonctionnement du dispositif.
PCT/US2020/000003 2019-01-07 2020-01-07 Régulation du flux sanguin WO2020146178A1 (fr)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022036173A1 (fr) * 2020-08-14 2022-02-17 Becton, Dickinson And Company Dispositif de prélèvement sanguin, et systèmes et procédés associés

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4140108A (en) * 1977-08-10 1979-02-20 Becton, Dickinson And Company Blood collection assembly
US4409991A (en) * 1980-02-04 1983-10-18 Becton Dickinson And Company Fluid flow control device for use with an evacuated blood collection container
EP0916307A1 (fr) * 1997-11-13 1999-05-19 C.G.M. S.P.A. Dispositif pour le prélèvement des liquides corporels et pour les transférer dans des éprouvettes
WO1999048425A1 (fr) * 1998-03-25 1999-09-30 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Dispositif de prelevement d'echantillons
US7255251B1 (en) * 2001-07-31 2007-08-14 Jason Smith Holding appliance for facilitating blood drawing process
WO2013028759A1 (fr) * 2011-08-22 2013-02-28 The General Hospital Corporation Évaluation de coagulation
US9427707B2 (en) 2012-08-10 2016-08-30 Jean I. Montagu Filtering blood
US20180140240A1 (en) * 2016-11-18 2018-05-24 Magnolia Medical Technologies, Inc. Systems and methods for sample collection with reduced hemolysis

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4140108A (en) * 1977-08-10 1979-02-20 Becton, Dickinson And Company Blood collection assembly
US4409991A (en) * 1980-02-04 1983-10-18 Becton Dickinson And Company Fluid flow control device for use with an evacuated blood collection container
EP0916307A1 (fr) * 1997-11-13 1999-05-19 C.G.M. S.P.A. Dispositif pour le prélèvement des liquides corporels et pour les transférer dans des éprouvettes
WO1999048425A1 (fr) * 1998-03-25 1999-09-30 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Dispositif de prelevement d'echantillons
US7255251B1 (en) * 2001-07-31 2007-08-14 Jason Smith Holding appliance for facilitating blood drawing process
WO2013028759A1 (fr) * 2011-08-22 2013-02-28 The General Hospital Corporation Évaluation de coagulation
US9427707B2 (en) 2012-08-10 2016-08-30 Jean I. Montagu Filtering blood
US20180140240A1 (en) * 2016-11-18 2018-05-24 Magnolia Medical Technologies, Inc. Systems and methods for sample collection with reduced hemolysis

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022036173A1 (fr) * 2020-08-14 2022-02-17 Becton, Dickinson And Company Dispositif de prélèvement sanguin, et systèmes et procédés associés

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