WO2020143892A2 - Probiotic which cures covid 19 patients by transfer of natural passive immunity from immunised cows - Google Patents

Probiotic which cures covid 19 patients by transfer of natural passive immunity from immunised cows Download PDF

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WO2020143892A2
WO2020143892A2 PCT/DZ2020/050006 DZ2020050006W WO2020143892A2 WO 2020143892 A2 WO2020143892 A2 WO 2020143892A2 DZ 2020050006 W DZ2020050006 W DZ 2020050006W WO 2020143892 A2 WO2020143892 A2 WO 2020143892A2
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sars
cov
patients
colostrum
cows
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WO2020143892A3 (en
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Nassira LACHLAK
Ishaq BENSEBTI
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Lachlak Nassira
Bensebti Ishaq
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Publication of WO2020143892A3 publication Critical patent/WO2020143892A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/20—Milk; Whey; Colostrum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/04—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from milk
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1002—Coronaviridae
    • C07K16/1003—Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2 or Covid-19]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/12—Immunoglobulins specific features characterized by their source of isolation or production isolated from milk

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  • This biotic pro is also used as a preventive against Corona virus infection.
  • the invention relates to a technique for transferring natural passive immunity from the infected cow to humans.
  • This cow infection technique was performed on 18:
  • Aim of the invention Transfer of natural passive immunity from cow colostrum containing anti-SARS-CoV-2 IgG to cure infected patients within three days without sequelae when they are in an exponential contamination phase.
  • the age range of these healthy people who have used this probiotic is at ages different from younger to older. Taking this colostrum containing SARS-CoV-2 antibodies provides a natural means of immunization in this patient. The goal is to follow these people on the serological assessment plan over 6 months in order to know the time it takes for an immunization against SARS-CoV-2.
  • Figures 1, 2, 3, 4, 4 bis show fact sheets on some families consisting of 4 to 10 members infected with SARS-CoV-2 and whose symptoms are sometimes different.
  • Taking colostrum containing anti-SARS-CoV antibody 2 shows a full recovery after the 4 th day of consumption of the latter. It is noted that the infection is due to contagion by an individual within the same family.
  • COVID19 mutates from one patient to another since there are some symptoms that are different.
  • Cow colostrum contains important macrophage cells, cells that provide the first line of defense.
  • Colossal leukocytes correspond mainly at macrophages (40 to 50. A part of these cells crosses the intestinal barrier, at the level of the Payer plates of the Jejunum and Neon, gains the blood circulation of the calf to join the lymphoid organs and provides defense against any foreign body
  • Colostrum is the support for the transfer of passive immunity from mother to calf: it is a humoral transfer, passage of immunoglobulins from mother to calf by colostrum (the calf has acquired humoral immunity through maternal antibodies.
  • This immunity is made up of a very large percentage of IgG ranging from 50 to 100%, more specifically lgG1.
  • the IgGI is the majority isotope in the colostrum, their catch goes straight on] es
  • the colostrum of the latter is of good quality, since the concentration of IgG is greater than 50 g / L).
  • This threshold value is found in practically all dairy cows and not in suckler cows the threshold value is between 80-10Og / l of IgG (colostrum of excellent condition).
  • the quality of the colostrum of the dairy cow does not become of good quality when the IgG level is 50g / l the case of Prim Holstein cows according to the studies the average IgG concentrations varies significantly it is 41 g / l of IgG (bad colostrum)
  • the cow and 2 nd lactation are more at risk of producing a poor quality colostrum in IgG,
  • Another parameter to take into account an intake of oral selenium in the food ration increases the level of IgG
  • IgG Passive immunity transfer
  • - iodine regulates the general metabolism and conditions the general condition of the animal and its immunity in the pre-immunization phase experienced months before calving.
  • the primary infection of pregnant cows begins at the end of the 7th month with a reminder from the parturition phase.
  • the level of colostrum IgG is between 80 and 100 g / l.
  • the invention resides in the infection of heifers and cows of the 3rd and 4th carried by the blood of patients infected with COVID 19 (viremia), The aim is to produce colostral antibodies rich in anti SARS-CoV-2 antibodies .
  • the immunization of COVID 19 patients depends on the physical presence of anti SARS-CoV-2 antibodies found in the colostrum of the colostrum from these formerly infected cows and are immunized.
  • Improper freezing destroys IgG or loss of the effect of direct protection of calf's cellular immunity. Freezing has the advantage of stopping the multiplication of bacteria and in order not to destroy IgG, we must proceed with a successive thawing in order to preserve the antibodies present in the colostrum. The taking of this pro-biotics was done on 50 patients infected with COVID19. All patients are healed between 3 to 4 days, perfect healing without sequelae.
  • the invention resides in a first infection with the blood of a COVID19 patient on 6 first-breed heifers of the fleckvieh breed (‘German). These cows are isolated in islets in order to limit contamination to 20 km from the farm on a hill far from the cattle.
  • Cameras are installed in each cow boxing to monitor the signs of viremia. Feeding is given over 10 days, in order to protect himself Veterinary Doctor Ishaq Bensebti notes the signs of infection by camera for each heifer Cows show the same signs as humans dry cough, fever, anorexia and diarrhea with traces of blood in the stool.
  • the three pregnant heifers have given birth and the newborn calves are in perfect health except one which has an apparent brain tumor with an open brain.
  • the veterinary doctor Ishaq who caused the viremia was infected by this SARS-CoV-2 with signs of fever, aches, dry cough respiratory distress, his healing was felt as soon as he consumed the colostrum of the pregnant heifers immunized his health recovered on the 4th days after consumption.
  • cows are isolated in islets in order to limit contamination between them.
  • Each 4 cows are infected with the blood of a COVID19 patient who is cured from the first experience.
  • the calving of cows was done at the same period of an interval of 1 to 10 days with an ultrasound machine specifying the date of gestation in order to determine their dates of parturition.
  • Calves are born in perfect condition, fed by colostrum rich in SARS-CoV-2 antibodies, in order to strengthen their immunization.
  • the colostrum of the 12 cows was mixed in order to have a mixture of SARS-CoV-2 Antibodies giving a broad spectrum on the passive immunization of this virus.

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Abstract

The invention relates to a technique for the transfer of natural passive immunity via the colostrum of gestating cows infected with SARS-COV-2. These COVID19 cows developed immunity, producing colostrum rich in anti-SARS-COV-2 IgG antibodies. This colostrum is a natural probiotic of the immunised cow having circulating anti-SARS-COV-2 antibodies which is curative and preventive for patients infected with COVID19 and healthy patients. The worsening of cases is found in patients with serious pathological conditions and patients who are overweight. SARS-COV-2 infection causes severe respiratory distress ending up in intensive care; feeding can be done using a feeding tube, the viral load is stopped by this probiotic, but the prognosis is poor from the pulmonary and cerebral point of view. COVID19 patients who have recovered develop anti-SARS-COV-2 antibody immunity that can be seen in the serological test. This colostrum is stored using a cold lyophilisation technique which makes it possible to keep the anti-SARS-COV-2 IgGs 99% viable.

Description

Titre de l’invention ; Le pro biotique qui guérit les patients COVID 19 par le transfert de l’immunité passive naturelle a partir des Vaches immunisées. Title of the invention; The biotic pro that cures COVID 19 patients by transferring natural passive immunity from immunized cows.
Domaine technique auquel se rapporte l’invention ; Guérison des patients atteignent du COVID19 par le Colostrum de vache. Ce pro-biotique est administré aux patients en phase de contamination du COVID19. La disparition des symptômes est visible dés le deuxième jour de la consommation du colostrum qui est riche en IGG anticorps anti CIOVID19. Technical field to which the invention relates; Healing of patients reach COVID19 by Cow Colostrum. This pro-biotic is administered to patients in the COVID19 contamination phase. The disappearance of the symptoms is visible from the second day of consumption of the colostrum which is rich in IGG antibodies against CIOVID19.
Le troisième jour de prise du colostrum riche en anticorps anti COVID19, les symptômes disparaissent de façon spectaculaire et les patients sont immunisés.. On the third day of taking colostrum rich in anti COVID19 antibodies, the symptoms disappear dramatically and the patients are immunized.
Ce pro biotique est utilisé aussi à titre préventif contre l’infection du Corona virus.This biotic pro is also used as a preventive against Corona virus infection.
L’invention concerne une technique de transfert d’immunité passive naturelle de la vache infecté à l’humain. Cette technique d’infection de vache a été réalisée sur 18 :The invention relates to a technique for transferring natural passive immunity from the infected cow to humans. This cow infection technique was performed on 18:
10 vaches de la première, 4 vaches de la 3eme et 4 vaches de la 4eme portée. Un vétérinaire Algérien spécialisé dans le domaine, .son infection au COVID19 la amener à trouvé l’antidote par les vaches de son exploitation. 10 cows from the first, 4 cows from the 3 rd and 4 cows from the 4 th litter. An Algerian veterinarian specializing in the field, her COVID19 infection led her to find the antidote for the cows on her farm.
Cette idée de ce génie m’a donnée l’idée d’effectuer un protocole de transfert de l’immunité passive naturelle de la vache aux patients COVID19. This idea of this genius gave me the idea of carrying out a protocol for transferring natural passive immunity from the cow to COVID19 patients.
11 s’agit d’un Procédé curative des patients infectés par le SARS-CoV2, cette technique demeure extraordinaire car la guérison des patients en phase 11 is a curative process for patients infected with SARS-CoV2, this technique remains extraordinary because the healing of patients in phase
exponentielle de contamination. exponential contamination.
Dans un délai de trois jours avec une prise régulière à jeun le matin de ce pro biotique pour tous les patients de tout âge. L’aggravation des cas réside chez avec des pathologies chroniques comme pour les patients diabétiques, cardiaques, hypertendus. Within three days with a regular fasting in the morning of this biotic pro for all patients of all ages. The aggravation of the cases resides at with with chronic pathologies as for the diabetic, cardiac, hypertensive patients.
Etat de la technique antérieure : State of the prior art:
A ce jour, les applications de transfert de l’immunité passive naturelle de la vache à l’Homme des anticorps Anti COVID19 restent encore inexploitées et nous sommes leaders mondiaux dans ce domaine de recherche. D’autres parts ce pro biotique de colostrum est administré à titre préventive et curative contre le SRAS-CoV-2, sans avoir recours à une vaccination. L’immunisation se fera de façon naturelle. To date, the applications of transfer of the natural passive immunity from cow to man of Anti COVID19 antibodies remain still untapped and we are world leaders in this research field. On the other hand, this biotic pro colostrum is administered as a preventive and curative against SARS-CoV-2, without the need for vaccination. Immunization will take place naturally.
Cette application est validée sur 50 patients COVID19 qui sont traités par ces pro biotiques de colostrum de vache. A titre préventive nous avons immunisés 100 des patients sains avec le colostrum possédant des Anticorps spécifique au SRAS COV. This application is validated on 50 COVID19 patients who are treated with these pro biotic cow colostrum. As a preventive measure, we have immunized 100 healthy patients with colostrum possessing specific antibodies to SARS VOCs.
But de l’invention : Le transfert de l’immunité passive naturelle du colostrum de la vache contenant des IgG anti- SRAS-CoV-2permettant de guérir les patients infectés en l’espace de trois jours sans séquelles lorsqu’ils sont en phase exponentielle de contamination. Aim of the invention: Transfer of natural passive immunity from cow colostrum containing anti-SARS-CoV-2 IgG to cure infected patients within three days without sequelae when they are in an exponential contamination phase.
Les patients dont l’infection est chronique avec une détresse respiratoire Patients with chronic infection with respiratory distress
Sont guéris en espace de 3 à 4 jours par la consommation de ce colostrum. Par contre les patients dont l’insuffisance devient chronique bronchés en service de réanimation, le pronostic est engagé au niveau cérébrale, la charge virale peut être stoppée mais le cerveau et les poumons sont endommagés le risque est prévision et rapidité aux aspects nouveaux des infections comme le diabète, les pneumopathies nosocomiale, cardiopathies et bien d’autres pathologies, qui touchent une population à tout âge confondu. Are cured within 3 to 4 days by the consumption of this colostrum. On the other hand, patients whose insufficiency becomes chronically bronchial in the intensive care unit, the prognosis is engaged at the cerebral level, the viral load can be stopped but the brain and the lungs are damaged. diabetes, nosocomial pneumonia, heart disease and many other pathologies, which affect a population of all ages.
Nous avons donner à des proches qui ont sains non infectés par le SRAS-CoV-2 . We have given to loved ones who have healthy non-SARS-CoV-2 infection.
La tranche d’âge de ces personnes sains qui ont consommé ce probiotique est à des âges différents du plus jeunes au plus âgés. La prise de ce colostrum contenant des anticorps SRAS-CoV-2 présent un moyen d’immunisation naturelle chez ce patients. Le but de suivre ces personnes sur le plan bilan sérologiques sur 6 mois afin de connaître le temps que met une immunisation contre le SRAS-CoV-2. The age range of these healthy people who have used this probiotic is at ages different from younger to older. Taking this colostrum containing SARS-CoV-2 antibodies provides a natural means of immunization in this patient. The goal is to follow these people on the serological assessment plan over 6 months in order to know the time it takes for an immunization against SARS-CoV-2.
Ensuite voir dans le temps si au cours de la pandémie, ils vont être contaminés par quelqu’un positif COVID12de la famille ou de l’extérieur. Ce probiotique peut est un moyen d’immunisation naturelle et saine de la population non infectées (en parlera de la prévention0 Then see in time if during the pandemic, they will be infected by someone positive COVID12 from the family or from outside. This probiotic can is a natural and healthy means of immunization of the uninfected population (talk about prevention 0
Nous œuvrons actuellement le moyen de conservation de ce colostrum par une technique de lyophilisation à froid permettant de garder 99% les IGG viable. We are currently working on the means of preserving this colostrum by a cold freeze-drying technique allowing 99% of IGGs to be kept viable.
1.3 Enoncé des figures : 1.3 Statement of figures:
De toutes les Façons, l’invention sera bien comprise à l’aide de description qui suit, en référence des données annexés de ces fiches de renseignements des patients avec des symptômes différents. In any case, the invention will be clearly understood with the aid of the description which follows, with reference to the data appended to these information sheets for patients with different symptoms.
Figures 1 , 2, 3 ,4, 4 bis : montrent des fiches de renseignements sur quelques familles se composant de 4 à 10 membres infectées par le SRAS-CoV-2 et dont les symptômes sont parfois différents. Figures 1, 2, 3, 4, 4 bis: show fact sheets on some families consisting of 4 to 10 members infected with SARS-CoV-2 and whose symptoms are sometimes different.
La prise du colostrum contenant des anticorps anti SRAS-CoV-2 montre une guérison totale au bout du 4emejours de la consommation de ce dernier. On remarque que l’infection est due à une contagion par un individu au sein de la même famille.Taking colostrum containing anti-SARS-CoV antibody 2 shows a full recovery after the 4 th day of consumption of the latter. It is noted that the infection is due to contagion by an individual within the same family.
On pourra tirer une conclusion que le COVID19 mute d’un patient à un autre puisqu’il y’a quelques symptômes qui sont différents We can conclude that COVID19 mutates from one patient to another since there are some symptoms that are different.
Présentation de l’invention. Presentation of the invention.
Le colostrum des vaches contient d’importantes cellules de macrophages, cellules qui assurent la première ligne de défense Les leucocytes colossaux correspondent majoritairement à des macrophages (40 à 50. Une partie de ces cellules traverse la barrière intestinale, au niveau des plaques de Payer du Jéjunum et de Néon, gagne la circulation sanguine du veau pour rejoindre les organes lymphoïdes et assurent la défense contre tout corps étranger Cow colostrum contains important macrophage cells, cells that provide the first line of defense. Colossal leukocytes correspond mainly at macrophages (40 to 50. A part of these cells crosses the intestinal barrier, at the level of the Payer plates of the Jejunum and Neon, gains the blood circulation of the calf to join the lymphoid organs and provides defense against any foreign body
Nous avons eu l’idée de transférer les anticorps anti SRAS-CoV-2en les We had the idea to transfer the anti SARS-CoV-2 antibodies into them
consommant dans le colostrum de la vache qu’on infecte avec le SRAS-CoV-2 du sang des patients infectés : On parle alors de L’immunité passive naturelle. consuming in the colostrum of the cow that is infected with SARS-CoV-2 from the blood of infected patients: This is called natural passive immunity.
Le colostrum est le support de transfert de l’immunité passive de la mère au veau: il s’agit d’un transfert humoral, passage des Immunoglobulines de la mère au veau par le colostrum (le veau est doté d’une immunité humorale acquise par l’intermédiaire des Anticorps maternels. Cette immunité est constituée d’un pourcentage d’IgG très important allant de 50 à 100% est plus particulièrement les lgG1. Colostrum is the support for the transfer of passive immunity from mother to calf: it is a humoral transfer, passage of immunoglobulins from mother to calf by colostrum (the calf has acquired humoral immunity through maternal antibodies. This immunity is made up of a very large percentage of IgG ranging from 50 to 100%, more specifically lgG1.
L’IgGI est l’isotope majoritaire dans le colostrum, leur prise va droit sur ]es
Figure imgf000004_0001
The IgGI is the majority isotope in the colostrum, their catch goes straight on] es
Figure imgf000004_0001
Notre choix d’expérimentation s’est fait sur des vaches gestantes de le 1 ème, 3eme et 4eme portée, de race Montbéliard (Française) et de race Fleckvieh (Allemande).Our choice of experiment was made on pregnant cows of the 1 st, 3 rd and 4 th litters, of the Montbéliard breed (French) and of the Fleckvieh breed (German).
Le colostrum de ces dernières est de bonne qualité, car la concentration en IgG est supérieur à 50g/L). Cette valeur seuil se trouve pratiquement chez toutes les vaches laitières et non chez les vaches allaitantes la valeur seuil est entre 80- 10Og/l d’IgG (colostrum d’excellent état). La qualité du colostrum de la vache laitière ne devient pas de bonne qualité lorsque le taux des IgG est de 50g/l le cas des vaches de race Prim Holstein selon les études les concentrations moyennes en IgG varie de façon importante elle est de 41 g/l d’IgG (mauvais colostrum) The colostrum of the latter is of good quality, since the concentration of IgG is greater than 50 g / L). This threshold value is found in practically all dairy cows and not in suckler cows the threshold value is between 80-10Og / l of IgG (colostrum of excellent condition). The quality of the colostrum of the dairy cow does not become of good quality when the IgG level is 50g / l the case of Prim Holstein cows according to the studies the average IgG concentrations varies significantly it is 41 g / l of IgG (bad colostrum)
Notre choix s’est fait aussi sur des. Des vaches gestantes à partir de la 3eme 4eme, portée, car elle produisent le bon colostrum riche en IgG. Our choice was also made on. Pregnant cows from the 3rd 4th litter, because they produce good colostrum rich in IgG.
La vache et 2eme lactation sont plus à risque de produire un colostrum de mauvaise qualité en IgG, The cow and 2 nd lactation are more at risk of producing a poor quality colostrum in IgG,
Il est important de signaler de part notre expérience que la saison du vêlage joue un rôle important la qualité du colostrum est significativement élevée en IgG en mois de Août septembre et Octobre et elle plus faible en décembre janvier et février. It is important to note from our experience that the calving season plays an important role the quality of colostrum is significantly high in IgG in August September and October and it lower in December January and February.
Le choix de cette saison est fait car la pandémie bas le record en décès et en infections. Nous avons éliminé le facture de saisons, car il y’a urgence. Il est vrai que le climat et l’alimentation jouent un rôle important. The choice of this season is made because the pandemic lowers the record for deaths and infections. We have eliminated the season bill because there is an emergency. It is true that climate and food play an important role.
Un autre paramètre à tenir compte un apport de sélénium par voie orale dans la ration alimentaire augmente le taux des IgG Another parameter to take into account an intake of oral selenium in the food ration increases the level of IgG
L’échec de transfert d’immunité (IgG) passive qui est inférieur de 10g/I entraîne la mortalité du veau à la naissance par rapport à notre expérience de notre bétail qu’on a dans la ferme et de notre expérience dans le domaine. Passive immunity transfer (IgG) failure which is 10g / I lower results in calf mortality at birth compared to our experience with our livestock on the farm and our experience in the field.
Lors de l’infection virale la pathologie respiratoire est moins instructive. En effet, l’immunité en IgG protège les voies respiratoires que partiellement,. La prise du colostrum diminue les signes cliniques, les lésions pulmonaires diminuent l’excrétion virale,, jusqu’à son élimination totale. During viral infection the respiratory pathology is less instructive. Indeed, IgG immunity only partially protects the respiratory tract. Taking colostrum reduces clinical signs, pulmonary lesions reduce viral excretion, until its total elimination.
-L’alimentation reste aussi un facteur important pour un avoir un bon colostrum, l’apport des compléments alimentaire tel que le sélénium participe à une bonne production d’hormones thyroïdiennes et active le système immunitaire., -Food also remains an important factor for having a good colostrum, the supply of food supplements such as selenium participates in a good production of thyroid hormones and activates the immune system.,
- l’iode : régule le métabolisme général et conditionne l’état général de l’animal et son immunité en phase pré immunisation expérimentéel mois avant le vêlage. - iodine: regulates the general metabolism and conditions the general condition of the animal and its immunity in the pre-immunization phase experienced months before calving.
La Primo infection des vaches gestantes débute fin du 7eme mois avec un rappel dés la phase de parturition. A la naissance le taux des IgG du colostrum est entre 80 et 100 g/l . The primary infection of pregnant cows begins at the end of the 7th month with a reminder from the parturition phase. At birth the level of colostrum IgG is between 80 and 100 g / l.
L’invention réside sur l’infection des génisses et des vaches de la 3eme et 4eme portées par du sang des patients infectés par le COVID 19 (virémie), Le but est de produire des anticorps colostraux riche en anticorps anti SRAS-CoV-2. The invention resides in the infection of heifers and cows of the 3rd and 4th carried by the blood of patients infected with COVID 19 (viremia), The aim is to produce colostral antibodies rich in anti SARS-CoV-2 antibodies .
L’immunisation des patients COVID 19 dépend de la présence physique des anticorps anti SRAS-CoV-2 se trouvant dans le colostrum du colostrum provenant de ces vaches anciennement infectées est immunisées.. The immunization of COVID 19 patients depends on the physical presence of anti SARS-CoV-2 antibodies found in the colostrum of the colostrum from these formerly infected cows and are immunized.
Le bon choix du colostrum provient des vaches qui ont déjà subit une infection transitoire et non permanent. The right choice of colostrum comes from cows that have already suffered a transient and not permanent infection.
Nous avons administré du colostrum congelé et du colostrum frais. ayx patients COVID19 la guérison est totale en espace de 3-4 jours pour les patients qui consomment du colostrum frais ou congelés. We administered frozen colostrum and fresh colostrum. in COVID19 patients, healing is complete within 3-4 days for patients who consume fresh or frozen colostrum.
La mauvaise congélation détruit les IgG d’ou perte de l’effet de la protection direct de l’immunité cellulaire du veau La congélation à l’avantage de stopper la multiplication des bactéries et afin de ne pas détruire les IgG, on doit procéder à une décongélation successives afin de préserver les anticorps présent dans le colostrum.. La prise de ce pro-biotiques à été faite sur 50 patients infectés par le COVID19. Tous les patients sont guérit entre 3 à 4 jours, guérison parfaite sans séquelles. Improper freezing destroys IgG or loss of the effect of direct protection of calf's cellular immunity. Freezing has the advantage of stopping the multiplication of bacteria and in order not to destroy IgG, we must proceed with a successive thawing in order to preserve the antibodies present in the colostrum. The taking of this pro-biotics was done on 50 patients infected with COVID19. All patients are healed between 3 to 4 days, perfect healing without sequelae.
Mode de réalisation de l’invention : Method of carrying out the invention:
L’invention réside sur une première infection par du sang d’un patient COVID19 sur 6 génisses de première portée de race fleckvieh (‘Allemande). Ces vaches sont isolées dans des ilôts afin de limiter les contaminations à 20 km de l’exploitation sur une colline loin du bétail. The invention resides in a first infection with the blood of a COVID19 patient on 6 first-breed heifers of the fleckvieh breed (‘German). These cows are isolated in islets in order to limit contamination to 20 km from the farm on a hill far from the cattle.
Des caméras sont installées dans chaque boxe de vache, afin de contrôler les signes de la virémie. L’alimentation est donnée sur 10 jours, afin de se protéger le docteur Vétérinaire Ishaq Bensebti relève les signes de l’infection par caméra pour chaque génisse Les vaches présentent les mêmes signes que l’Homme toux sèche, fièvre, anorexie et diarrhée avec des traces de sang dans les selles. Cameras are installed in each cow boxing to monitor the signs of viremia. Feeding is given over 10 days, in order to protect himself Veterinary Doctor Ishaq Bensebti notes the signs of infection by camera for each heifer Cows show the same signs as humans dry cough, fever, anorexia and diarrhea with traces of blood in the stool.
Deux génisses ont fait une mis bas avant terme. Les veaux naissant sont décédés sur place. Afin de sauver ces deux génisses dont l’infection les a beaucoup affaiblies. Two heifers have given birth before term. Newborn calves died on the spot. In order to save these two heifers whose infection has weakened them a lot.
Nous avons provoqué la mis bas par une injection d’Ocytocine chez une génisse qui a supportée la virémie et guérit. Le Colostrum de cette dernière à été administré aux deux génisses malades qui ont fait une mis bas avant le terme. Le résultat est spectaculaire les deux vaches se sont rétablies en espaces de 4 jours aucun signe et l’état de santé de ces deux génisses est parfait. We brought about the birth by an injection of Oxytocin into a heifer who supported the viremia and healed. The latter's Colostrum was administered to the two sick heifers who gave birth before term. The result is spectacular the two cows recovered within 4 days no sign and the health of these two heifers is perfect.
Les trois génisses gestantes ont eu une mis bas à terme et les veaux naissant sont en parfait état de santé sauf un veau qui présente une tumeur au cerveau apparente avec un cerveau ouvert. The three pregnant heifers have given birth and the newborn calves are in perfect health except one which has an apparent brain tumor with an open brain.
Le Docteur vétérinaire Ishaq qui a provoqué la virémie a été infecté par ce SRAS- CoV-2 avec des signes de fièvre, courbatures, toux sèche détresse respiratoire, sa guérison à été ressentis dés qu’il a consommé le colostrum des génisses gestantes immunisées son état de santé s’est rétabli au 4eme jours après la consommation.The veterinary doctor Ishaq who caused the viremia was infected by this SARS-CoV-2 with signs of fever, aches, dry cough respiratory distress, his healing was felt as soon as he consumed the colostrum of the pregnant heifers immunized his health recovered on the 4th days after consumption.
Nous avons mis en place un protocole qui permet d’effectuer un passage de l’immunité passive naturelle du colostrum riche en IgG SRAS-CoV-2 chez des familles infectés par le Corona Virus à des âges entre 3 à 84 ans. Chaque famille est composée entre 6 à 10 personnes COVID19 déclaré positif par le direction de la santé de l’état est qui sont en quarantaine (isolement) chez eux. We have implemented a protocol that allows the passage of natural passive immunity from colostrum rich in IgG SARS-CoV-2 in families infected with the Corona Virus at ages between 3 and 84 years old. Each family is made up of between 6 and 10 COVID19 people declared positive by the eastern state health department who are in quarantine (isolation) at home.
Dans chaque famille on remarque des signes différents par une contamination d’un même COVID19. La prise du colostrum pro-biotique donne une disparition de la fièvre et courbature à partir du deuxième jour. A la troisième prise du colostrum (3eme jour), on constate qu’il y’a une disparition totale de la toux et les autres signes dés le lendemain, et une guérison des patients COVID19 . In each family, there are different signs of contamination from the same COVID19. Taking the pro-biotic colostrum gives a disappearance of the fever and aches from the second day. At the third strike colostrum (3rd day), we see that there's a total disappearance of cough and other signs the very next day, and healing COVID19 patients.
Afin d’enrichir notre pro-biotique et de donner un large spectre en immunité contre ce COVID19. A la deuxième d’expérience, nous avons infectés ces 12 vaches gestantes entre 7eme mois et 8eme mois par du sang des 3 patients COVID19. In order to enrich our pro-biotic and to give a broad spectrum in immunity against this COVID19. In the second experiment we infected these 12 pregnant cows between 7 th and 8 th month month by the blood of 3 COVID19 patients.
Le choix s’est fait sur 4 génisses gestantes, 4 vaches gestantes de la 3eme portée et 4 vaches de la 4eme portée, ces vaches sont de race flekvieh et Montbéliard de poids identiques (800kg) avec une alimentation équilibrée complétée par des minéraux et vitamines sélénium, iode, calcium etc.), afin de bien de booster leurs immunité The choice was made on 4 pregnant heifers, 4 pregnant cows of the 3 rd litter and 4 cows of the 4 th litter, these cows are of the Flekvieh and Montbéliard breed of identical weight (800kg) with a balanced diet supplemented with minerals and vitamins selenium, iodine, calcium etc.), in order to boost their immunity
Ces vaches sont isolées dans des ilôts afin de limiter les contaminations entre elles. These cows are isolated in islets in order to limit contamination between them.
Chaque 4 vaches sont infectées par le sang d’un patient COVID19 qu’on à guérit de la première expérience. Each 4 cows are infected with the blood of a COVID19 patient who is cured from the first experience.
Il s’agit de 3 infections par du sang des patients COVID19. Au quatrième jour de la virémie, nous avons administré du colostrum riche en Anticorps du SRAS-CoV-2, afin de les aider à lutter contre l’infection et aussi de protéger le fœtus (en évitant le franchissement le des barrières placentaire). These are 3 blood infections of COVID19 patients. On the fourth day of the viremia, we administered colostrum rich in Antibodies to SARS-CoV-2, in order to help them fight against the infection and also to protect the fetus (by avoiding the crossing of placental barriers).
La mis à bas des vaches à été faite à une même période d’un intervalle de 1 à 10 jours avec un échographe précisant la date de gestation afin de déterminer leurs dates de parturition. The calving of cows was done at the same period of an interval of 1 to 10 days with an ultrasound machine specifying the date of gestation in order to determine their dates of parturition.
Les veaux sont nés en parfaite état, nourrit par le colostrum riche en anticorps SRAS-CoV-2, afin de renforcer leurs immunisation. Calves are born in perfect condition, fed by colostrum rich in SARS-CoV-2 antibodies, in order to strengthen their immunization.
Le colostrum des 12 vaches à été mélangé afin d’avoir un mélange d’Anticorps SRAS-CoV-2 donnant un large spectre sur l’immunisation passive de ce virus. The colostrum of the 12 cows was mixed in order to have a mixture of SARS-CoV-2 Antibodies giving a broad spectrum on the passive immunization of this virus.
Sur 1080 L de colostrum collectés, nous avons pu guérir 50 patients COVID19 avec une prise de colostrum pendant 3 jours. la moitié des personnes qui ont bu le colostrum frais et le‘autre moitié du colostrum décongelé. La guérison est total, sauf que les patients I COVID19 qui ont bu le colostrum décongelé la disparition es symptômes se fait en 5 jours au lieu de 4 jours. Là guérison est spectaculaire, de plus les patients sont immunisés par les anticorps SRAS-CoV-2. Out of 1080 L of colostrum collected, we were able to cure 50 COVID19 patients by taking colostrum for 3 days. half of those who drank fresh colostrum and the other half of thawed colostrum. The cure is total, except that the patients I COVID19 who drank the colostrum thawed the disappearance of symptoms is done in 5 days instead of 4 days. There the healing is spectacular, moreover the patients are immunized by the SARS-CoV-2 antibodies.
Les patients COVID19 après guérison, ils développent une immunité puisque aprèsCOVID19 patients after healing, they develop immunity since after
10 jours de guérison. Ils ont effectués des tests sérologiques en dosant le taux des IgG et IgM, les résultats montrent que le taux des IgG est supérieur à la normale et les IgM faible, ce qui explique qu’ils ont développés une forte immunité contre le SRAS-CoV-2 10 days of healing. They carried out serological tests by measuring the level of IgG and IgM, the results show that the level of IgG is higher than normal and the IgM low, which explains why they developed a strong immunity against SARS-CoV- 2
Ce qui parait spectaculaire le docteur vétérinaire qui est aussi immunisé, le fait d’être en visite chez ces patients COVID19 pour leur administrer le colostrum contenant les anticorps anti SRAS-CoV-2, sont taux des Ig G est 5 fois plus que la normale e les IgM faible. Cela explique que le fait de consommer du colostrum contenant des anticorps SRAS-CoV-2 son immunité en .anticorps anti SRAS-CoV-2 est plus que la normale. What seems spectacular the veterinary doctor who is also immunized, the fact of visiting these COVID19 patients to administer the colostrum containing the anti SARS-CoV-2 antibodies, their Ig G levels are 5 times higher than normal e low IgM. This explains why consuming colostrum containing SARS-CoV-2 antibodies its immunity to anti-SARS-CoV-2 antibodies is more than normal.
Le moyen de congélation du colostrum riche en ANTICORPS SRAS COV ne peut être valable que 6 mois. De ce fait nous avons opté pour une lyophilisation du colostrum afin de conserver les IgG anti SRAS-CoV-2. The means of freezing colostrum rich in ANTIBODY SARS VOC can only be valid for 6 months. As a result, we opted for lyophilization of the colostrum in order to conserve the anti SARS-CoV-2 IgG.
11 suffit juste de réhydraté le colostrum lyophilisé dans de l’eau à 37 ° réactiver les anticorps anti SRAS-CoV-2., prêt à la consommation dans un but d’immunisation. It is just sufficient to rehydrate the lyophilized colostrum in water at 37 ° to reactivate the anti SARS-CoV-2 antibodies., Ready for consumption for the purpose of immunization.
Fiche 1 de Renseignements de quelques familles infectées par le C0VID19 Avec Prise de Pro biotique colostrum des vaches immunisées par SRAS-CoV-2
Figure imgf000008_0001
Fiche 2 de Renseignements de quelques familles infectées par le C0VID19 Avec Prise de Pro biotique colostrum des vaches immunisées par SRAS-CoV-2
Figure imgf000009_0001
Fiche 3 de Renseignements de quelques familles infectées par le C0VID19 Avec Prise de Pro biotique colostrum des vaches immunisées par SRAS-CoV-2
Figure imgf000010_0001
Figure imgf000011_0001
Information sheet 1 of some families infected with C0VID19 With Taking Pro biotic colostrum from cows immunized with SARS-CoV-2
Figure imgf000008_0001
Information sheet 2 of some families infected with C0VID19 With Taking Pro biotic colostrum from cows immunized with SARS-CoV-2
Figure imgf000009_0001
Information sheet 3 of some families infected with C0VID19 With Intake of Pro biotic colostrum from cows immunized with SARS-CoV-2
Figure imgf000010_0001
Figure imgf000011_0001
Fiche 4 de Renseignements de quelques familles infectées par le C0VID19 Avec Prise de Pro biotique colostrum des vaches immunisées par SRAS-CoV-2
Figure imgf000012_0001
Fiche 4 BIS de Renseignements de quelques familles inlectées par le C0VID19 Avec Prise de Pro biotique colostrum des vaches immunisées par SRAS-CoV-2
Figure imgf000013_0001
Information sheet 4 of some families infected with C0VID19 With Taking Pro biotic colostrum from cows immunized with SARS-CoV-2
Figure imgf000012_0001
Sheet 4 BIS of Information of some families affected by C0VID19 With Taking of Pro biotic colostrum from cows immunized by SARS-CoV-2
Figure imgf000013_0001

Claims

7 7
REVENDICATIONS
1 - La réception artificielle de la transmission par une méthode virémique du SARS-CoV-2 des vaches par le sang des patients COVID19 permet à la vache gestante de plus de sept mois de déclencher le passage des immunoglobulines appelées( IgG) ou anticorps (AC) anti SRAS-CoV-2 par voie claustrale.. 1 - The artificial reception of the transmission by a viremic method of SARS-CoV-2 of cows by the blood of COVID19 patients allows the pregnant cow of more than seven months to trigger the passage of called immunoglobulins (IgG) or antibodies (AC ) anti SARS-CoV-2 claustrally.
2- L’immunisation passive naturelle qui se fait par le Colostrum frais ou congelé ou lyophilisé riche en AC anti SRAS-CoV-2 selon la revendication 1 permet de guérir les patients COVID19. 2- The natural passive immunization which is done by fresh or frozen or lyophilized Colostrum rich in anti-SARS-CoV-2 AC according to claim 1 makes it possible to cure COVID19 patients.
3- Les patients COVID19 qui consomment le colostrum (riche en IgG anti SRAS- CoV-2, de ces vaches infectées par le SRAS COV-2 selon les revendications 2 et 3. Ils voient une guérison totale en 3-4 jours et sans séquelle par rapport à cette maladie COVID19. 3- COVID19 patients who consume colostrum (rich in anti SARS-CoV-2 IgG, of these cows infected with SARS COV-2 according to claims 2 and 3. They see a total cure in 3-4 days and without sequelae in relation to this COVID19 disease.
4- Selon la revendication 3, les symptômes de l’infection par le virus sont différents d’un patient à un autre au sein d’une même famille contaminée par une espèce de Corona virus. Ces symptômes se manifestent par une toux sèche fièvre, sueur, courbature saignement, des troubles digestifs, maux de tête, douleurs thoracique, détresse respiratoire, écoulement nasale, congestion nasale voir la figure 2 et 3 des fiches de renseignements. 4- According to claim 3, the symptoms of virus infection are different from one patient to another within the same family contaminated with a species of Corona virus. These symptoms are manifested by a dry cough, fever, sweat, bleeding aches, digestive problems, headache, chest pain, respiratory distress, runny nose, nasal congestion see Figures 2 and 3 of the fact sheets.
5- L’immunisation passive des patients COVID 19 dépend de la présence physique des anticorps colostraux (provenant des vaches immunisées) dans leurs intestins pendant 3 jours selon la revendication 1 et 2, l’immunisation reste un moyen naturel pour renforcer le système immunitaire puisque les anticorps anti SRAS COV-2 secrétées dans le colostrum. Le fait de consommer ce colostrum riche en IgG anti SRAS-CoV-2 des vaches immunisées, les patients symptomatiques ou asymptomatiques s’immunisent contre ce Corona Virus. 5- Passive immunization of COVID 19 patients depends on the physical presence of colostral antibodies (from immunized cows) in their intestines for 3 days according to claim 1 and 2, immunization remains a natural way to strengthen the immune system since anti SARS COV-2 antibodies secreted in colostrum. By consuming this colostrum rich in anti-SARS-CoV-2 IgG from immunized cows, symptomatic or asymptomatic patients are immunized against this Corona Virus.
6- Le SRAS-CoV-2 qui a affaiblit les vaches gestantes à la parturition du veau présente des séquelles comme tumeurs au cerveau ou la mort du veau à la naissance, à cause d’une parturition prématurée causée par l’infection. 6- SARS-CoV-2, which weakened pregnant cows when the calf is born, has sequelae such as brain tumors or death of the calf at birth, due to premature birth caused by infection.
7- Lorsqu’on infecte les vaches de la 1 ère ou la 3eme et 4eme portée par le sang des patients COVID19 et on leurs donne à boire du colostrum riche en anticorps anti SRAS COV juste après l’infection. Le virus, n’affecte pas le fœtus, probablement les barrières placentaires ne sont pas touchées puisque à la naissance des veaux on ne remarque aucune séquelle. 8 7- When the cows of the 1st or 3rd and 4th carried by the blood of COVID19 patients are infected and they are given colostrum rich in anti-SARS COV antibodies just after infection. The virus does not affect the fetus, probably the placental barriers are not affected since at the birth of the calves no sequelae are noticed. 8
8- L”immunité est vaches gestantes infectées par le SRAS-CoV est renforcée .par l’administration du colostrum riche en anticorps anti SRAS-CoV dans les 72 heures de poste infection. Ce processus permet pour réduire la potentialité des modalités de l’infection. 8- The immunity of pregnant cows infected with SARS-CoV is strengthened. By the administration of colostrum rich in anti-SARS-CoV antibodies within 72 hours of infection. This process helps to reduce the potentiality of the infection modalities.
9- Les patients C0VID19 après guérison, ils développent une immunité puisque après 10 jours de guérison. Ils ont effectués des tests sérologiques en dosant le taux des IgG et IgM, les résultats montrent que le taux des IgG est supérieur à la normale ( entre 75-150 Ul/ml) et les IgM négatifs (entre 0.3 - 0.5 Ul/ml), ce qui explique qu’ils ont développés une forte immunité contre le SRAS-CoV-2. Ce qui apparaît spectaculaire le docteur vétérinaire qui est aussi immunisé, le fait d’être en visite chez ces patients COVID19 pour leur administrer le colostrum contenant les anticorps anti SRAS-CoV-2, son taux des Ig G est 10 fois plus que le taux des patients immunisés e les IgM faible. Cela explique que le fait de consommer du colostrum contenant des anticorps SRAS-CoV-2 son immunité en .anticorps anti SRAS-CoV-2 est plus que la normale , de plus de son ancienne immunisation. 9- C0VID19 patients after healing, they develop immunity since after 10 days of healing. They carried out serological tests by measuring the level of IgG and IgM, the results show that the level of IgG is higher than normal (between 75-150 IU / ml) and the negative IgM (between 0.3 - 0.5 IU / ml) , which explains why they developed a strong immunity against SARS-CoV-2. What appears spectacular the veterinary doctor who is also immunized, the fact of visiting these COVID19 patients to administer the colostrum containing the anti SARS-CoV-2 antibodies, his Ig G level is 10 times higher than the rate immunized patients with low IgM. This explains why consuming colostrum containing SARS-CoV-2 antibodies its immunity to anti-SARS-CoV-2 antibodies is more than normal, in addition to its former immunization.
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