WO2020139298A3 - Cellular and humoral immunity augmenter multiple phase emulsion vaccine adjuvant against animal diseases - Google Patents

Cellular and humoral immunity augmenter multiple phase emulsion vaccine adjuvant against animal diseases Download PDF

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Publication number
WO2020139298A3
WO2020139298A3 PCT/TR2019/051208 TR2019051208W WO2020139298A3 WO 2020139298 A3 WO2020139298 A3 WO 2020139298A3 TR 2019051208 W TR2019051208 W TR 2019051208W WO 2020139298 A3 WO2020139298 A3 WO 2020139298A3
Authority
WO
WIPO (PCT)
Prior art keywords
augmenter
vaccine adjuvant
multiple phase
humoral immunity
phase emulsion
Prior art date
Application number
PCT/TR2019/051208
Other languages
French (fr)
Other versions
WO2020139298A2 (en
Inventor
Muhammet BUYUKBAYRAM
Original Assignee
Reakim Endustriyel Performans Katkilari Kimyevi Maddeler Sanayi Ve Ticaret Ltd. Sti.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reakim Endustriyel Performans Katkilari Kimyevi Maddeler Sanayi Ve Ticaret Ltd. Sti. filed Critical Reakim Endustriyel Performans Katkilari Kimyevi Maddeler Sanayi Ve Ticaret Ltd. Sti.
Publication of WO2020139298A2 publication Critical patent/WO2020139298A2/en
Publication of WO2020139298A3 publication Critical patent/WO2020139298A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • A61K35/04—Tars; Bitumens; Mineral oils; Ammonium bituminosulfonate
    • A61K35/06—Mineral oils, e.g. paraffinic oils or aromatic oils based on aromatic hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention relates to vaccine adjuvant used with the purpose of protection of animal health in the field of veterinary. The referred adjuvant shows cellular and humoral immunity augmenter effect in its use. The adjuvant being the subject of the invention also increases the shelf life of vaccines, and provides a much longer life cycle for the vaccines due to its multiple phase emulsion. The referred vaccine adjuvant contained pharmaceutical mineral oil, surface active agents, and purified lyophilized additives from plants.
PCT/TR2019/051208 2018-12-27 2019-12-25 Cellular and humoral immunity augmenter multiple phase emulsion vaccine adjuvant against animal diseases WO2020139298A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2018/20780 2018-12-27
TR2018/20780A TR201820780A2 (en) 2018-12-27 2018-12-27 MULTIPLE PHASE EMULSION VACCINE ADJUVANT FOR CELLULAR AND HUMORAL IMMUNITY AGAINST ANIMAL DISEASES

Publications (2)

Publication Number Publication Date
WO2020139298A2 WO2020139298A2 (en) 2020-07-02
WO2020139298A3 true WO2020139298A3 (en) 2020-08-13

Family

ID=67980158

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/TR2019/051208 WO2020139298A2 (en) 2018-12-27 2019-12-25 Cellular and humoral immunity augmenter multiple phase emulsion vaccine adjuvant against animal diseases

Country Status (2)

Country Link
TR (1) TR201820780A2 (en)
WO (1) WO2020139298A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0059521A1 (en) * 1981-03-03 1982-09-08 Centraal Diergeneeskundig Instituut Water-in-oil emulsion for use in the potentation of the immune system of animals
US5904925A (en) * 1993-12-09 1999-05-18 Exner; Heinrich Adjuvant for antigens, and process for making
CN105854013A (en) * 2015-01-22 2016-08-17 中牧实业股份有限公司 Animal vaccine adjuvant and animal vaccine thereof
CN106692966A (en) * 2015-07-29 2017-05-24 刘卓灵 Adjuvant for animal vaccines, and preparation method and application thereof
CN108014104A (en) * 2018-01-22 2018-05-11 青岛科技大学 A kind of Synergistic type dihydromyricetin soluble type compound and preparation method thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0059521A1 (en) * 1981-03-03 1982-09-08 Centraal Diergeneeskundig Instituut Water-in-oil emulsion for use in the potentation of the immune system of animals
US5904925A (en) * 1993-12-09 1999-05-18 Exner; Heinrich Adjuvant for antigens, and process for making
CN105854013A (en) * 2015-01-22 2016-08-17 中牧实业股份有限公司 Animal vaccine adjuvant and animal vaccine thereof
CN106692966A (en) * 2015-07-29 2017-05-24 刘卓灵 Adjuvant for animal vaccines, and preparation method and application thereof
CN108014104A (en) * 2018-01-22 2018-05-11 青岛科技大学 A kind of Synergistic type dihydromyricetin soluble type compound and preparation method thereof

Also Published As

Publication number Publication date
WO2020139298A2 (en) 2020-07-02
TR201820780A2 (en) 2019-03-21

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