Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
  • A61M1/02—Blood transfusion apparatus
  • A61M1/029—Separating blood components present in distinct layers in a container, not otherwise provided for
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
  • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
  • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
  • B01L3/5021—Test tubes specially adapted for centrifugation purposes
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
  • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
  • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M2202/00—Special media to be introduced, removed or treated
  • A61M2202/04—Liquids
  • A61M2202/0413—Blood
  • A61M2202/0427—Platelets; Thrombocytes
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
  • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
  • B01L2200/02—Adapting objects or devices to another
  • B01L2200/023—Adapting objects or devices to another adapted for different sizes of tubes, tips or container
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
  • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
  • B01L2200/06—Fluid handling related problems
  • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
  • B01L2200/0652—Sorting or classification of particles or molecules
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
  • B01L2300/00—Additional constructional details
  • B01L2300/04—Closures and closing means
  • B01L2300/041—Connecting closures to device or container
  • B01L2300/042—Caps; Plugs
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
  • B01L2300/00—Additional constructional details
  • B01L2300/08—Geometry, shape and general structure
  • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped

Definitions

• the present invention is related to PRP production preparation devices and systems and is also related to means and systems used for separating different elements of blood from one another and is also related to polymer structures and especially polymers with medical grade.
• Blood is composed of two parts; that is, normal cells and blood plasma.
• normal blood cells blood contains mainly red blood cells and less white blood cells (leucocytes) as well as platelets.
• white blood cells leucocytes
• plasma part it is constituted of water, protein, minerals and some other minor elements.
• PRP separation is to obtain part of blood which is produced by red marrow as cellular elements especially for coagulation under urgent circumstances.
• the application of PRP in healing wounds, accelerating follicles reconstruction and growth in skeleton reconstruction is proved helpful in previous years.
• PRP separation is done by two methods: Container is used for the first method and in the second method, they use gel. They call these methods container-based or gel-based depending on which method to apply. In the second method in which gel is applied, only a small portion of platelets are centrifuged out of blood and can be later used and is neither cost-effective nor helpful. However, there is higher efficiency for separating platelets in the second method.
• phases are separated in the blood containers by the help of centrifuge. Red blood cells exist in the lowest level. White blood cells are in the next layer and platelets are at top of other two levels.
• Patent KR10114055 IB 1 under the title Buffy coat extraction kit for self blood skin renewal procedure
• Patent KR101145173B1 under the title Separate type platelet rich plasma extraction kit
• Patent KR200471027Y1 under the title Device for separating platelet rich plasma with a coagulation catalyst
• Patent KR200471024Y1 under the title Disposable container for separating platelet rich plasma
• the purpose of the invention is to design and produce a means for efficiency in the separation of PRP from blood elements such that the utmost density and purity is observed and cells and blood elements are least damaged.
• the present invention is a kind of polymeric cylinder which has a similar diameter on the outside at bottom and top and similar diameter or different size at the inside which its ratio of diameter to its height can be any amount.
• plastic lid which is most times made of Polypropylene or any other polymers that has flexibility in diameter, enables it to be fixed in the depressed part and not move towards the bottom of the container as a result of centrifugal force during centrifugation because of the existence of protrusion on it.
• On upper part of the lid there is a specific connection for connecting syringe through which operator or doctor can extract the content of container if necessary by pushing lid down. Thus, separated blood elements can be extracted without chaos.
• the cylindrical container ' s lid is made of medical grade Polypropylene or any other polymers that has flexibility in diameter.
• the lid is in the form of a small cylinder whose external size is perfectly congruent with the container ' s internal size.
• In lower section of the lid there is a protuberant belt which is semicircular.
• This lid has a conic shape in the lower of entrance duct and this shape similar to a conical shape.
• Semicircular shape of exterior side of container ' s belt gets the lid fixed inside the container.
• Over the frame of the main container there is a depressed shape frame in the opening of the container which is symmetrical with the belt-like protrusion of the lid.
• the collar locates itself in the inner depressions of the container when container door is settled in its place and as a result the movement of lid down during centrifugation of the container's content is impossible because of presence of centrifugal force.
• the lid could be made of polymers with plastic features or rubber structures.
• the present lid in upper section is equipped with a threaded connection. This connection can be directly related to where syringe is fixed or used as an interface for the installation an adapter for changing syringe size or possible Peripheral venous catheter.
• the door can have a one-piece connection or equipped only with a threaded structure for the installation of lid.
• concentrator In middle section of cylinder, there is a unit called concentrator which can create an appropriate environment for the high concentration PRP with white blood cells' gathering.
• the shape of intermediary unit in external part is cylindrical and is semi-conical inside and exits from the other side of cylinder.
• the concentrator is made of Polypropylene or any other polymer that can be qualified in terms of defined standards.
• a concentrator in middle section and a projected collar in exterior which surrounds the unit like a belt.
• the concentrator is inserted inside the cylinder and belt section is inserted around the unit inside the depression.
• the insertion of this projection in the middle of the depression in the cylinder keeps the concentrator in its place during centrifugation.
• the existence of a flat or semicircular surface is possible.
• a calibrated unit displays the necessary amount of blood to fill the device. After the reception of blood from the donator on whom the PRP operation is done, blood is poured into the cylinder with the help of a syringe or blood bag or needle.
• the lid on the cylinder is shut down and cylinder inside the centrifuge. If more PRP is required, two cylinders can be simultaneously used.
• anticoagulant is used. Anticoagulant can already be in the cylinder or kept in an ampule and later added to the cylinder by an injection when necessary.
• constituent elements of blood are separated from one another and red blood cells as well as some of high concentration platelets with white cells are settled in concentrator passage.
• Low concentration PRP unit and remaining plasma are in upper section of the cylinder above and PPP part stay on the upper section of blood elements.
• lid moves from its place by placing the cylinder in the support stand and installation of a syringe in upper section of the cylinder by pressing it into the lid.
• low concentration PRP in upper section enters the first syringe.
• required of high concentration PRP from cylinder can be inserted in the syringe.
• concentrator can be moved by further push and lid alongside with the unit will keep moving downward.
• white blood cell phase which is separated can enter the syringe and by pushing both elements down, red blood cells must connect to the fourth syringe.
• white blood cells phase and red blood cells phase can be collected by the help of a connected needle to the syringe which enters from upper hole of the lid.
• belt protrusion around the concentrator, exterior environment of this unit can be made in the form of stair and interior section of cylinder in the form of a projected step in lower section.
• This shape of concentrator can be other shape similar to conic shape by similar shape at the end of cylinder. Needle and syringe should be used for obtaining lower phases of blood.
• Contractor part can be located in external section with smaller diameter.
• the conical shape of the lid helps us for extracting phases by high quality because we can take up each phase without turbulence.
• This invention can use without concentrator part as a simple PRP set.
• the cylinder and lid use as a PRP set and after filing the blood into the cylinder, operator use of centrifuge for separating phases of blood.
• we didn’t have concentrate on the high quality platelet and the conical shape of the lid is a special part for concentration each part of the phases. So, we can use this set by concentrator part and without concentrator part.
• this invention is an apparatus for PRP set production with the help of cylinders equipped with fixed and fixed and mobile internal structure for increasing Platelets density
• calibrated cylinder, concentrator unit of separated phases, lid and size adapter that which used cylinder in the invention can be made of transparent polymers with medical grade or glass and the cylinder in claim number one in its entrance and middle section has depression with a semi circular cross-section and cylinder can have flat or spherical surface and which lid can be made of Polypropylene or any elastic polymer and door lids in exterior have projected collars and lid has a hole in middle and the middle hole is threaded and lid in the middle Hole section can be a place for closing lid door and the threaded middle hole is where an adapter, peripheral venous catheter, syringe or any other means can be fixed and the concentrator can be made of Polypropylene or any other transparent elastic polymer and the concentrator has cylindrical shape equal in size or conic shape to interior section of cylinder and the concentrator has a protuberant collar and a belt in
• Figure number one that shows the overview of the PRP package.
• Figure number two that shows the overview of PRP package by the conical shape at the end of the concentrator.
• FIG. 3 that shows the overview of PRP package by the stairs shape at the end of the concentrator.
• Figure number four that shows overview of PRP package by the narrow shape at the middle of the concentrator.
• Figure number eight that shows overview of the lid and tools for resizing.

Landscapes

• Health & Medical Sciences (AREA)
• Heart & Thoracic Surgery (AREA)
• Chemical & Material Sciences (AREA)
• Hematology (AREA)
• General Health & Medical Sciences (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Biomedical Technology (AREA)
• Pathology (AREA)
• Clinical Laboratory Science (AREA)
• Investigating Or Analysing Biological Materials (AREA)
• Anesthesiology (AREA)
• Engineering & Computer Science (AREA)
• Analytical Chemistry (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• External Artificial Organs (AREA)
• Vascular Medicine (AREA)

Priority Applications (1)

Applications Claiming Priority (1)

Publications (1)

Family

ID=71102968

Family Applications (1)

Country Status (1)

• 2018
  • 2018-12-16 WO PCT/IB2018/060154 patent/WO2020128563A2/fr active Application Filing

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