WO2020121006A3 - Method and apparatus to produce nanoparticles in an ostwald ripening flow device with tubes of variable path length - Google Patents

Method and apparatus to produce nanoparticles in an ostwald ripening flow device with tubes of variable path length Download PDF

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Publication number
WO2020121006A3
WO2020121006A3 PCT/HU2019/050046 HU2019050046W WO2020121006A3 WO 2020121006 A3 WO2020121006 A3 WO 2020121006A3 HU 2019050046 W HU2019050046 W HU 2019050046W WO 2020121006 A3 WO2020121006 A3 WO 2020121006A3
Authority
WO
WIPO (PCT)
Prior art keywords
tube member
tubes
ostwald ripening
path length
lower tube
Prior art date
Application number
PCT/HU2019/050046
Other languages
French (fr)
Other versions
WO2020121006A2 (en
Inventor
Ferenc Darvas
Enikő MANEK
Hunor MAKKAI
Original Assignee
Innostudio Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innostudio Inc. filed Critical Innostudio Inc.
Publication of WO2020121006A2 publication Critical patent/WO2020121006A2/en
Publication of WO2020121006A3 publication Critical patent/WO2020121006A3/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/0004—Preparation of sols
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/0004—Preparation of sols
    • B01J13/0043—Preparation of sols containing elemental metal
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00788—Three-dimensional assemblies, i.e. the reactor comprising a form other than a stack of plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00858—Aspects relating to the size of the reactor
    • B01J2219/0086—Dimensions of the flow channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00858—Aspects relating to the size of the reactor
    • B01J2219/00864—Channel sizes in the nanometer range, e.g. nanoreactors

Abstract

The present invention relates to a method and apparatus for producing nanoparticles in an Ostwald ripening flow device comprising tubes of variable path length. The method comprising subjecting the nanoparticles to Ostwald ripening, the Ostwald ripening being performed in a channel system comprising tubes of continuously variable path length, wherein for optimal Ostwald ripening the path length of the tubes being varied by slid- ing a lower tube member and an upper tube member relative to each other to a desired extent, said lower tube member comprising channels extending parallel with one another, said upper tube member comprising a sealing toothing that blocks each channel at one end thereof and arranged displaceably on the lower tube member to form the device with the channel system comprising said tubes. The apparatus comprises a channel system defining a flow path with an inlet and an outlet for Ostwald ripening of nanoparticles, wherein the flow path of the channel system is formed by a combination of a lower tube member (100) comprising channels extending parallel with one another and an upper tube member (200) comprising a sealing toothing (230) that blocks each channel at one end thereof and displaceably connected to the lower tube member. Furthermore, said lower tube member and said upper tube member are slidable relative to each other to a desired extent to enable continuous variability of the length of each tube formed by the channels of said channel system.
PCT/HU2019/050046 2018-10-19 2019-10-21 Method and apparatus to produce nanoparticles in an ostwald ripening flow device with tubes of variable path length WO2020121006A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862747729P 2018-10-19 2018-10-19
US62/747,729 2018-10-19

Publications (2)

Publication Number Publication Date
WO2020121006A2 WO2020121006A2 (en) 2020-06-18
WO2020121006A3 true WO2020121006A3 (en) 2020-10-01

Family

ID=70977541

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/HU2019/050046 WO2020121006A2 (en) 2018-10-19 2019-10-21 Method and apparatus to produce nanoparticles in an ostwald ripening flow device with tubes of variable path length

Country Status (1)

Country Link
WO (1) WO2020121006A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101618308B (en) * 2009-06-09 2011-12-21 宋玉军 Microfluid reactor based nano-particle preparation and particle controlled preparation process
WO2011158053A1 (en) * 2010-06-18 2011-12-22 Nanoform Cardiovascular Therapeutics Ltd. Nanostructured aprepitant compositions, process for the preparation thereof and pharmaceutical compositions containing them
WO2016138175A1 (en) * 2015-02-24 2016-09-01 The University Of British Columbia Continuous flow microfluidic system

Family Cites Families (13)

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Publication number Priority date Publication date Assignee Title
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
DE4440337A1 (en) 1994-11-11 1996-05-15 Dds Drug Delivery Services Ges Pharmaceutical nanosuspensions for drug application as systems with increased saturation solubility and dissolution rate
US6884436B2 (en) 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
US20070122440A1 (en) 2005-07-20 2007-05-31 Macosko Christopher W Methods for producing nanoparticles
WO2007150030A2 (en) 2006-06-23 2007-12-27 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
US8974827B2 (en) 2007-06-04 2015-03-10 Bend Research, Inc. Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer
WO2009061406A1 (en) 2007-11-05 2009-05-14 The Trustees Of Princeton University Nanoparticles for photodynamic therapy
US9943490B2 (en) 2007-11-05 2018-04-17 The Trustees Of Princeton University Composite flash-precipitated nanoparticles
EP2273978A1 (en) 2008-04-23 2011-01-19 Merck Sharp & Dohme Corp. Nanoparticle formation via rapid precipitation
US8541511B2 (en) 2008-07-07 2013-09-24 Arkema Inc. Amphiphilic block copolymer formulations
US10016517B2 (en) 2011-08-08 2018-07-10 Rutgers, The State University Of New Jersey Bioactive amphiphilic polymer stabilized nanoparticles with enhanced stability and activity
WO2013134089A1 (en) 2012-03-06 2013-09-12 The Regents Of The University Of Michigan Nanoparticles coated with amphiphilic block copolymers
WO2015061768A1 (en) 2013-10-25 2015-04-30 Massachusetts Institute Of Technology High-throughput synthesis of nanoparticles

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101618308B (en) * 2009-06-09 2011-12-21 宋玉军 Microfluid reactor based nano-particle preparation and particle controlled preparation process
WO2011158053A1 (en) * 2010-06-18 2011-12-22 Nanoform Cardiovascular Therapeutics Ltd. Nanostructured aprepitant compositions, process for the preparation thereof and pharmaceutical compositions containing them
WO2016138175A1 (en) * 2015-02-24 2016-09-01 The University Of British Columbia Continuous flow microfluidic system

Also Published As

Publication number Publication date
WO2020121006A2 (en) 2020-06-18

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