WO2020113324A1 - Sonde parodontale optique comprenant un matériau thermochromique pour mesurer la profondeur et/ou la température d'une poche parodontale - Google Patents

Sonde parodontale optique comprenant un matériau thermochromique pour mesurer la profondeur et/ou la température d'une poche parodontale Download PDF

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Publication number
WO2020113324A1
WO2020113324A1 PCT/CA2019/051733 CA2019051733W WO2020113324A1 WO 2020113324 A1 WO2020113324 A1 WO 2020113324A1 CA 2019051733 W CA2019051733 W CA 2019051733W WO 2020113324 A1 WO2020113324 A1 WO 2020113324A1
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WIPO (PCT)
Prior art keywords
probe
periodontal
temperature
probe tip
pocket
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PCT/CA2019/051733
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English (en)
Inventor
Rejean Munger
Claire MCLAUGHLIN
Cecilia ODONKOR
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Winterra Global Technologies Inc.
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Publication date
Application filed by Winterra Global Technologies Inc. filed Critical Winterra Global Technologies Inc.
Publication of WO2020113324A1 publication Critical patent/WO2020113324A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C19/00—Dental auxiliary appliances
    • A61C19/04—Measuring instruments specially adapted for dentistry
    • A61C19/043—Depth measuring of periodontal pockets; Probes therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0088—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for oral or dental tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/107—Measuring physical dimensions, e.g. size of the entire body or parts thereof
    • A61B5/1076—Measuring physical dimensions, e.g. size of the entire body or parts thereof for measuring dimensions inside body cavities, e.g. using catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/107—Measuring physical dimensions, e.g. size of the entire body or parts thereof
    • A61B5/1079—Measuring physical dimensions, e.g. size of the entire body or parts thereof using optical or photographic means

Definitions

  • An Optical Periodontal Probe Comprising a Thermochromic Material for Measuring Depth and/or Temperature of a Periodontal Pocket
  • the present invention relates to the field of dentistry, specifically the periodontal diagnostic area.
  • this invention relates to an optical periodontal probe comprising a thermochromic material for measuring depth and/or temperature of a periodontal docket.
  • Periodontal disease is a progressive inflammatory disease affecting the tissues surrounding the teeth. While in early stages, the gums are swollen and bleed. To monitor the progression of periodontal disease a dental professional periodically measures the depths of the periodontal pockets surrounding the teeth. Periodontal disease is typically diagnosed by measuring any periodontal pockets around the teeth using a periodontal probe.
  • Periodontal pockets are defined as pathologic deepened gingival sulcus (i.e. the area of separation between the surrounding gingival tissue and the surface of the encompassed tooth) which is the result of detachment of gingiva from tooth. As periodontal disease progresses, the relative depth of the periodontal pocket increases. Measurements are usually taken in millimeters.
  • Periodontal probes are typically one-piece mechanical devices made of surgical steel which have lines, marks or colours (1 mm or 2mm spacing) to indicate the depth that the probe penetrates into the pocket between the tooth and the gum.
  • the pocket depth measurement is performed by a highly trained practitioner who must control the pressure applied and read depth from markings (1 mm or 2mm spacing) on the periodontal probe tip.
  • Conventional probing requires the operator to stop and record the depth of the periodontal pocket at least after the measurement of every tooth, or an assistant is required to record the measurements.
  • pocket depth is typically used to diagnose and monitor periodontal disease it may not be the best indicator of disease as it reflects the total history of the disease process and does not necessarily reflect the current inflammatory state of the involved tissue. Pocket depth cannot discriminate between currently active and inactive individual periodontal pockets. Increases in temperature of the periodontal pocket due to inflammation may be used as an indicator of periodontal disease. Pockets with active periodontal disease have higher temperatures than healthy pockets of anatomically equivalent teeth. In order for temperature to be a useful diagnostic tool for periodontal disease, differences among individuals and among the periodontal pockets of the same individual must be taken into consideration. The subgingival temperature depends on many physiological and external factors, for example whether or not the individual smokes. Posterior sites are generally hotter than anterior sites and the temperature is higher in the mandible than in the maxillae.
  • thermochromic liquid crystals one of a family of materials called thermochromics
  • U.S. 5,725,373 which teaches a periodontal probe tip made of strong flexible plastic with a thermochromatic plastic ingredient which changes colour above 100°F.
  • the probe of U.S. 5,725,373 uses a graduated marking to measure periodontal depth and as such still has a number of the deficiencies associated with conventional probes.
  • a photonic periodontal probe for measuring depth and/or temperature of a periodontal pocket comprising: a handle and an optically transmissive probe tip; said handle comprising one or more light sources for illuminating said probe tip and a detection means for detecting spectrum and intensity of light reflected from said probe tip; said probe tip having a proximal end connected to the handle and an opposite distal end for insertion into the periodontal pocket; and said probe tip having thermochromic material and a solid carrier material, wherein temperature of said periodontal pocket is determined from the wave length dependence reflected back to the detection means from the probe tip; and wherein the depth of the periodontal pocket is determined from the intensity of light reflected back to the detection means from probe tip.
  • Figure 1 illustrates examples of spectrum change with temperature.
  • Figure 2 illustrates examples of signal strength with thickness.
  • Figure 3 illustrates an exemplary probe model used for evaluating dimensions and ergonomics.
  • Figure 4 illustrates measured intensity change versus wavelength during sample cooling.
  • Figure 5 illustrates measured intensity change versus wavelength during sample heating.
  • Figure 6 illustrates normalised intensity change versus wavelength during sample cooling.
  • Figure 7 illustrates normalised intensity change versus wavelength during sample heating.
  • Figure 8 illustrates normalised intensity change versus temperature during sample cooling.
  • Figure 9 illustrates normalised intensity change versus temperature during sample heating.
  • Figure 10 illustrates binned intensity change versus temperature during sample cooling.
  • Figure 1 1 illustrates binned intensity change versus temperature during sample heating.
  • Figure 12 illustrates binned intensity versus temperature during sample cooling
  • Figure 13 illustrates binned intensity change versus temperature during sample heating.
  • Figure 14 illustrates absolute intensity ratio versus temperature during sample cooling.
  • Figure 15 illustrates absolute intensity ratios versus temperature during sample heating.
  • Figure 16 illustrates mean and standard deviation of absolute ratios during sample cooling.
  • Figure 17 illustrates mean and standard deviation of absolute ratios during sample heating.
  • Figure 18 illustrates binned intensity change versus temperature during sample cooling.
  • Figure 19 illustrate binned intensity change versus temperature during sample heating.
  • Figure 20 illustrates calibration and measured intensity change during sample cooling.
  • Figure 21 illustrates calibration and measured intensity change during sample heating.
  • Figure 22 illustrates error graphs showing respective temperature minima during cooling.
  • Figure 23 illustrates error graphs showing respective temperature minima during heating.
  • Figure 24 illustrates calibration and measured intensity change versus temperature range
  • Figure 25 is a photograph of the experimental setup.
  • Figure 26 is a photograph of the sample measurement site
  • Figure 27 is a photograph of the sample measurement site during data collection.
  • Figure 28 provides data analysis for wavelength selection
  • Figure 29 provides data analysis for temperature calibration algorithm.
  • Figure 30 illustrates depth vs signal for hybrid 0.6% TLC.
  • Figure 31 illustrates calibration and measured right singular vectors during sample heating.
  • Figure 32. illustrates calibration and measured right singular vectors during sample heating.
  • Figure 33 illustrates error graphs showing respective temperature minima, 30.0 - 30.5.
  • Figure 34 illustrates error graphs showing respective temperature minima, 33.0 - 33.5.
  • the present invention is based on the finding that a photonic methodology using
  • thermochromics may be used to provide the simultaneous measurement of temperature and depth of a periodontal pocket. Accordingly, the present invention relates to an optical periodontal probe comprising a thermochromic material for measuring depth and/or temperature of a periodontal pocket. Also provided are methods of measuring depth and/or temperature of a periodontal docket wherein temperature of the periodontal pocket is determined from the spectrum of light returning to the detection means from the probe tip; and wherein the depth of the periodontal pocket is determined from the wavelength dependent intensities returning from the probe tip.
  • the periodontal probe comprises a handle and an optically transmissive probe tip.
  • the handle comprises one or multiple light sources for illuminating the probe tip and a detection means for detecting wavelength dependence and intensity of light reflected from the probe tip.
  • the probe tip comprises thermochromic material and a optically transmissive solid carrier material.
  • thermochromic material is a first colour or colourless below a threshold temperature (T on ) and as temperature is increased, pass through a series of colours until a maximum temperature is reached and a particular colour is maintained or transparency restored.
  • the temperature of the periodontal pocket may be determined from the wavelength of light (spectrum or selective probing wavelengths) reflected back to the detection means from the probe tip.
  • the portion of the probe within the periodontal pocket is warmed above threshold temperature by the contact with the tissue and tooth and be coloured.
  • the portion of the probe outside the pocket will be below threshold temperature and will be colourless. Accordingly, the intensity of a particular range of wavelengths of light reflecting to the detection means from the probe tip may be used to determine periodontal pocket depth.
  • the probe measures temperature (the average temperature of the tissue in contact with the probe) to an accuracy of 0.5°C. In certain embodiments, the probe measures temperature to a resolution of 0.2°C. In certain embodiments, the probe is able to perform a full periodontal exam without performance loss in temperature measurements. In certain embodiments, the probe requires no more than 1 second to perform a temperature measurement. In certain embodiments, the probe measures temperature at least 10 times per second. In certain embodiments, the probe measures temperature 100 times per second.
  • Depth can also be monitored using the probe.
  • the portion of the probe within the pocket will be warmed above T on by the contact with the tissue and be activated (coloured).
  • the portion of the probe outside the pocket will be below T on and will be transparent.
  • the volume of interaction between the light and the activated TC is the volume within the gum pocket.
  • a shallow pocket will result in a small interaction volume (less signal) and a deep pocket a larger interaction volume (more signal).
  • the pocket depth is in this way encoded in the signal intensity.
  • the present invention provides a method of measuring periodontal pocket depth and/or temperature using a photonic periodontal probe comprising: a handle and an optically transmissive probe tip; the handle comprising a light source for illuminating said probe tip and a detection means for detecting spectrum and intensity of light reflected from said probe tip; the probe tip having a proximal end connected to the handle and an opposite distal end for insertion into the periodontal pocket; and the probe tip having thermochromic material and a solid carrier material, wherein temperature of said periodontal pocket is determined from the wave length dependence reflected back to the detection means from the probe tip; and wherein the depth of the periodontal pocket is determined from the intensity of light reflected back to the detection means from probe tip.
  • the probe measures pocket depth (the length of the tissue in contact with the probe) with an accuracy of 0.25mm. In certain embodiments, the probe measures pocket depth with a resolution of 0.2mm. In certain embodiments, the probe is able to perform a full periodontal exam without performance loss in depth measurements. In specific embodiments, the pocket depth measurement is the length of the probe tip that is in contact with gingival tissue when the end of the probe tip is in contact with the bottom of the pocket and with a pressure of 16g is applied. In certain embodiments, for a tip end of 0.5mm diameter the force targeted is 20 to 25g.
  • the probe monitors application pressure during periodontal probing. In certain embodiments, the probe monitors application pressure during periodontal probing to an accuracy of 0.5g. In certain embodiments, the probe monitors application pressure during periodontal probing to a resolution of 1 .0g. In certain embodiments, the probe monitors application pressure during periodontal probing to a resolution of 2.5g. In certain embodiments, the probe provides applied pressure feedback in real time.
  • the probe simultaneous measures of temperature and pocket depth for each site probed.
  • the amount of time required by the probe for simultaneous measurement of temperature and pocket depth is, on average no greater than the time required for conventional probes to measure depth alone. Periodontal probing of a site using a conventional probe takes an experienced clinician ⁇ 1 second.
  • temperature measurements shall be representative of the average temperature of the gingival tissue in contact with the probe during a valid pocket depth measurement. In another embodiment the temperature measured will be the bottom of the pocket.
  • the probe may be wired, wireless or both. In certain embodiments, the probe transmits data wireless to a receiver. In certain embodiments, the probe continuously monitors and transmits data from data input.
  • the probe tip is disposable. In other embodiments, the probe tip is reusable. In reusable embodiments, the probe tips can be sterilized after each use. In certain embodiments, the probe tip is at least as comfortable to the patient as conventional probes and does not increase risk to the patient (infection, allergic response, tissue damage, debris from tip).
  • the probe tip comprises a thermochromic material and a solid carrier material.
  • the thermochromic material may be coated on the carrier material or embedded in the carrier material. In certain embodiments, the thermochromic material is embedded in the carrier material.
  • the materials must be suitable for use in dental instruments. For example, a worker skilled in the art would readily appreciate that the materials used should produce a probe tip which maintains rigidity (no change in shape with pressure) during measurement, and has good resistance to breakage to ensure patient safety. In specific embodiments, the probe tips have ⁇ 0.5mm deviation under 20g axial pressure.
  • the carrier material for use in the probe tip must be compatible with the thermochromic material (i.e. does not inhibit the thermochromic properties of the thermochromic material or prevent detection of a thermochromic change).
  • the material is an optically transparent material. In specific embodiments, the material has at least 90% optical transparency.
  • the carrier material is moldable.
  • the carrier material is a polymer. In certain embodiments, the polymer is curable. In certain embodiments, the polymer is air curable. In other embodiments, the polymer requires the addition of an additive for curing.
  • the additive may be a chemical additive, light, including but not limited to UV, visible and NIR light, or heat. In certain embodiments, a chemical additive is used.
  • the polymer may be a thermoplastic or a thermoset polymer.
  • the polymer is an acrylate polymer (also known as aryclics or polyacrylates), such as polymethyl methacrylate (PMMA).
  • the polymer is a polyurethane. Appropriate polymers are commercially available, for example, the polyurethane PT8925 from PTM&W Products.
  • exemplary commercially available polymers include WC-780-AB; WC781 -AB; WC-782-AB; WC-783-AB; WC-784-AB; WC-786-AB; WC-788-AB; and WC-792-AB available from BJB Enterprises; Crystal Cast 1000, 2000, 3000, and 4000 from Alchemie and Water Clear Polyurethane Casting Resin from Easy Composites
  • thermochromic material for use in the probe tip is a reversible thermochromic material which changes colour over a physiological temperature range.
  • Non-limiting exemplary temperature ranges include but are not limited to 20°C to 50°C, 22°C to 40°C , 32°C to 40°C, 35°C to 40°C and 35°C to 40°C.
  • the temperature range of the thermochromic material is 32°C to 40°C. Accordingly, in certain embodiments, the T on is 32°C and the T max is 40°C.
  • thermochromic material may be in the form of a coating on the carrier material or may be embedded in the carrier material.
  • the probe tip may be a hollow structure in which the thermochromic material is on the internal surface.
  • the thermochromic material forms a coating
  • the thermochromic material forms a coating on the outside of the probe tip.
  • the thermochromic material may also be embedded in the carrier material.
  • the probe tip comprises thermochromic material embedded in the carrier material.
  • Thermochromic materials may be in the form of liquid crystals or thermochromic liquid crystals or Leuco Dyes.
  • the probe tip comprises thermochromic liquid crystals. Microencapsulation is known in the art as a means to stabilize and package liquid crystal and leuco dyes.
  • the thermochromic material is thermochromic microcapsules. In specific embodiments, the thermochromic material is thermochromic liquid crystal microcapsules.
  • Thermochromic materials, including but not limited to thermochromic liquid crystal microcapsules are commercially available. For example, microencapsulated TLC slurries are available from LCR Hallcrest.
  • the concentration of thermochromic material should be sufficient to quantify the depth but not too high that the light only interacts with a portion of the thermochromic material.
  • the concentration of thermochromic material must be less than 20% of the total material by weight. In certain embodiments, the concentration is between 1 % and 20%. In other embodiments, the concentration is between 5% and 15%. In further embodiments, the concentration is between 7% and 12%. In other embodiments, the concentration is about 1 %, about 2%, about 3%, about 4%, about 5%, about 6%, about 7%, about 8%, about 9%, about 10%, about 1 1 %, about 12%, about 13%, about 14%, about 15%, about 16%, about 17%, about 18%, or about 19%. In certain embodiments, the concentration is 10%.
  • thermochromic materials are microencapsulated TLC slurries with a Ton of 32 °C and a bandwidth of 8 °C.
  • thermochromic material and carrier material for use as the probe tip.
  • carrier material for use as the probe tip.
  • thermochromic materials are the microencapsulated TLC slurries from LCR Hallcrest with a red start of 32 °C and a bandwidth of 8 °C.
  • the mixture is produced as follows: Mix the chiral nematic liquid crystals with the B2 polyurethane hardener in a plastic container with a metal mixing instrument for 4
  • the TLC slurry is allowed to dry (desiccated) and ground to a fine powder which is then added to the carrier material
  • the probe tip is less than ⁇ 1 mm in thickness and at least 10mm in length.
  • the probe tip may have various cross sectional shapes including but not limited to circular, oval, concave or convex.
  • the probe handle comprises a zone for reversible attachment of the probe tip, a transition zone and a handle zone.
  • the probe handle comprises one or more light sources for illuminating the probe tip and a detection means for detecting spectrum and intensity of light reflected from said probe tip.
  • the one or more light sources may be one or more broadband light sources, one or more light sources with selective wavelength emissions, or a combination thereof.
  • the detection means may be a wavelength sensitive detector, such as a spectrometer or a detector that does not resolve wavelengths.
  • the probe handle may further comprise a means for pressure sensing.
  • the probe handle is capable of providing user feedback for low, acceptable and high pressures.
  • the pressure sensor has an accuracy of 0.5g when used in a human population.
  • the probe handle comprises an internal power source which is optionally rechargeable.
  • the charge lasts for 5 full periodontal exams. In certain embodiments, if the probe is operated with at least 15 minutes between each periodontal exam and power is provided during this 15 minute period, the probe can operate without down time for a full clinical day.
  • the probe handle transmits data wirelessly. In specific embodiments, the probe handle transmits all clinical and ancillary measurements / information over a wireless transmission interface to be permanently recorded in a digital chart. In specific embodiments, no information is lost during transmission over distances of up to 30’ with no wall between the receiver and the probe handle.
  • the probe handle manages all functions related to the photonics signals to and from the probe tip, including the photonic / optical components; manages the pressure monitoring system and provide feedback to the user; digitizes all analog signals required to perform the depth and temperature measurements as per the probe tip requirements; relates all information to be recorded wirelessly to a remotely connected device and operates without tethering to any other device during a periodontal exam.
  • the probe handle is reusable, a method of sterilizing the probe handle is also provided.
  • thermochromics (encased in polyurethane samples) to a change in temperature (22.0 ° C to 40.0 ° C).
  • This analysis was conducted by measuring the spectra emitted by the inactivated and activated thermochromics. Thermochromics are inactivated below 32.0 ° C and are activated between 32.0 ° C - 40.0 ° C.
  • the spectra intensities of the thermochromic samples at 22.0 ° C were the inactivated intensities.
  • thermochromic spectra intensities were measured by quantifying the amount of incident white light reflected off the surface of the thermochromic sample.
  • the maximum reflection of the white light is characterised by measuring the reflection against a white opal disk, which is representative of total reflection. This maximum reflection is known as the white light intensities, which were used to normalise the measured intensities of the samples.
  • the thermochromic samples were placed on a black absorbing disk then on the sample measurement site. The sample is heated up and the activated thermochromic response is located by moving the sample around under the incident white light fibre until the expected spectrum is observed. Once the thermochromic response has been identified at a location, x, on the sample surface, the spectra intensity at x is measured while cooling and heating the sample. The corresponding wavelengths and temperatures were recorded. Note that the spectra intensities were measured under a black cloth to avoid any contribution of ambient light to the measured data, hence minimizing experimental errors.
  • the spectra intensities of the sample were collected while heating (from 22.0 ° C to 40.0 ° C) and cooling (from 40.0 ° C to 22.0 ° C) the sample.
  • SigmaPlot 1 1 .0 the excel file Spectra Suite Data Summary. xls were imported. The raw data was graphed, that is, measured intensities against the wavelength range.
  • Figure 4 illustrates measured intensity change versus wavelength during sample cooling.
  • Figure 5 illustrates measured intensity change versus wavelength during sample heating. Note: Intensity measurements collected while heating or cooling the sample is denoted by FI/C at the end of the graph title. For example, S35C is representative of intensities measured while cooling Sample 35.
  • the following Import White Light and Graph_C02 macro was used normalise the measured intensities.
  • the normalised intensities were graphed against their corresponding wavelength ranges.
  • Figure 6 illustrates normalised intensity change versus wavelength during sample cooling.
  • Figure 7 illustrates normalised intensity change versus wavelength during sample heating.
  • Figure 8 illustrates normalised intensity change versus temperature during sample cooling.
  • Figure 9 illustrates normalised intensity change versus temperature during sample heating. Binned intensity change versus temperature
  • Bin lntensities_COv1 macro see Appendix C, Section C
  • the transposed intensities in 50 nm ranges
  • the binned intensities were graphed against the temperature range.
  • Bins (averages) the previously selected wavelength intensities in every 50 nm range, that is, 350 nm - 400 nm, 410 nm - 450 nm..., 760 nm - 800 nm
  • Figure 10 illustrates binned intensity change versus temperature during sample cooling.
  • Figure 1 1 illustrates binned intensity change versus temperature during sample heating.
  • the selected wavelength ranges of interest were 510 - 550 nm, 560 - 600 nm, and 510 - 650 nm.
  • the intensities of the selected wavelength ranges of each repeated sample experiment were compared. That is, compare 510 - 550 nm intensities of S35Run1 C to 510 - 550 nm intensities of S35Run2C, and so forth for all repeated experiments.
  • the multiple sample runs were graphed on the same plot to compare.
  • Figure 12 illustrates binned intensity versus temperature during sample cooling.
  • Figure 13 illustrates binned intensity change versus temperature during sample heating.
  • the Wavelength Ratio Transform was used to calculate the absolute ratios of the selected wavelength ranges to each other.
  • the absolute ratios of each repeated sample experiment were graphed against the temperature range and compare.
  • Figure 14 illustrates absolute intensity ratio versus temperature during sample cooling.
  • Figure 15 illustrates absolute intensity ratios versus temperature during sample heating.
  • Figure 16 illustrates mean and standard deviation of absolute ratios during sample cooling.
  • Figure 17 illustrates mean and standard deviation of absolute ratios during sample heating.
  • the selected wavelengths of interest were 510 nm, 560 nm, and 610 nm
  • the Sum of Squares macro was used calculate the sum of squares of the Calibration and Measured intensities.
  • the resulting minima plots were graphed for each half temperature from 22 ° C - 40 ° C, that is, 22.0 ° C, 22.5 ° C, 40.0 ° C
  • x(T), y(T), and z(T) are intensities of wavelengths 510 nm, 560 nm, and 650 nm
  • Figure 20 illustrates calibration and measured intensity change during sample cooling.
  • Figure 21 illustrates calibration and measured intensity change during sample heating.
  • Figure 22 illustrates error graphs showing respective temperature minima during cooling.
  • Figure 23 illustrates error graphs showing respective temperature minima during heating.
  • savg is the resulting mean nx1 matrix SMean(A) d - A
  • A is an nxm matrix
  • Figure 31 illustrates calibration and measured right singular vectors during sample heating.
  • Figure 32 illustrates calibration and measured right singular vectors during sample heating.
  • Figure 33 illustrates error graphs showing respective temperature minima, 30.0 - 30.5.
  • Figure 34 illustrates error graphs showing respective temperature minima, 33.0 - 33.5.

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Abstract

La présente invention concerne une sonde parodontale photonique pour mesurer la profondeur et/ou la température d'une poche parodontale. La sonde parodontale comprend : une poignée et une pointe de sonde optiquement transmissive ; ladite poignée comprenant une source de lumière pour éclairer ladite pointe de sonde et un moyen de détection pour détecter le spectre et l'intensité de la lumière réfléchie par ladite pointe de sonde ; ladite pointe de sonde ayant une extrémité proximale reliée à la poignée et une extrémité distale en regard de la poignée destinée à être insérée dans la poche parodontale ; ladite pointe de sonde ayant également un matériau thermochromique et un matériau de support solide, la température de ladite poche parodontale étant déterminée à partir de la dépendance à la longueur d'onde de la lumière réfléchie vers le moyen de détection par la pointe de sonde ; et la profondeur de la poche parodontale étant déterminée à partir de l'intensité de la lumière réfléchie vers le moyen de détection par la pointe de sonde.
PCT/CA2019/051733 2018-12-03 2019-12-03 Sonde parodontale optique comprenant un matériau thermochromique pour mesurer la profondeur et/ou la température d'une poche parodontale WO2020113324A1 (fr)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5725373A (en) * 1996-07-17 1998-03-10 Yeh; Richard T. Periodontal probe tip for diagnosing periodontitis and dental decay
JP2014004329A (ja) * 2012-06-01 2014-01-16 Sony Corp 歯用装置、医療用装置及び算出方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5725373A (en) * 1996-07-17 1998-03-10 Yeh; Richard T. Periodontal probe tip for diagnosing periodontitis and dental decay
JP2014004329A (ja) * 2012-06-01 2014-01-16 Sony Corp 歯用装置、医療用装置及び算出方法

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