WO2020112411A3 - System for continuous purification of biochemical mixtures - Google Patents

System for continuous purification of biochemical mixtures Download PDF

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Publication number
WO2020112411A3
WO2020112411A3 PCT/US2019/062012 US2019062012W WO2020112411A3 WO 2020112411 A3 WO2020112411 A3 WO 2020112411A3 US 2019062012 W US2019062012 W US 2019062012W WO 2020112411 A3 WO2020112411 A3 WO 2020112411A3
Authority
WO
WIPO (PCT)
Prior art keywords
module
wash
solution
chromatography resin
source
Prior art date
Application number
PCT/US2019/062012
Other languages
French (fr)
Other versions
WO2020112411A2 (en
Inventor
Sumitava De
Martial Hervy
Clemens Rudolf Horn
Nikolaos Pantelis KLADIAS
Elena Daniela Lavric
Jean-Pierre Henri Rene Lereboullet
Yuehao LI
Aravind Raghavan RAMMOHAN
Po Ki Yuen
Original Assignee
Corning Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corning Incorporated filed Critical Corning Incorporated
Publication of WO2020112411A2 publication Critical patent/WO2020112411A2/en
Publication of WO2020112411A3 publication Critical patent/WO2020112411A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/02—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor with moving adsorbents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/18—Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/08—Flat membrane modules
    • B01D63/082—Flat membrane modules comprising a stack of flat membranes
    • B01D63/084—Flat membrane modules comprising a stack of flat membranes at least one flow duct intersecting the membranes
    • B01D63/085—Flat membrane modules comprising a stack of flat membranes at least one flow duct intersecting the membranes specially adapted for two fluids in mass exchange flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/08—Flat membrane modules
    • B01D63/088—Microfluidic devices comprising semi-permeable flat membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
    • B01D65/08—Prevention of membrane fouling or of concentration polarisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/25—Recirculation, recycling or bypass, e.g. recirculation of concentrate into the feed
    • B01D2311/252—Recirculation of concentrate
    • B01D2311/2523—Recirculation of concentrate to feed side
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B01D2311/2674—Condensation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B01D2311/2697—Chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/04—Reciprocation, oscillation or vibration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/10—Cross-flow filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2317/00—Membrane module arrangements within a plant or an apparatus
    • B01D2317/02—Elements in series
    • B01D2317/022—Reject series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2317/00—Membrane module arrangements within a plant or an apparatus
    • B01D2317/06—Use of membrane modules of the same kind
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/04—Backflushing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/18—Use of gases
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/20—By influencing the flow
    • B01D2321/2033—By influencing the flow dynamically
    • B01D2321/2058—By influencing the flow dynamically by vibration of the membrane, e.g. with an actuator

Abstract

A multimodule system for continuous purification of biochemical mixtures is provided. The system includes at least one immobilization module in which chromatography resin from a resin source is contacted with a feed solution from a feed source to bind target compounds from the feed solution with the chromatography resin. The system also includes at least one wash module fluidly connected to the at least one immobilization module and to a wash solution source, wherein in the wash module, chromatography resin having target compounds bound thereto is contacted with a wash solution. The system further includes at least one elution module fluidly connected to the at least one wash module and to an eluent solution source, wherein in the elution module, chromatography resin having target compounds bound thereto is contacted with an eluent solution to release the target compounds from the chromatography resin.
PCT/US2019/062012 2018-11-30 2019-11-18 System for continuous purification of biochemical mixtures WO2020112411A2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201862773635P 2018-11-30 2018-11-30
US201862773625P 2018-11-30 2018-11-30
US201862773838P 2018-11-30 2018-11-30
US201862773618P 2018-11-30 2018-11-30
US62/773,838 2018-11-30
US62/773,618 2018-11-30
US62/773,625 2018-11-30
US62/773,635 2018-11-30

Publications (2)

Publication Number Publication Date
WO2020112411A2 WO2020112411A2 (en) 2020-06-04
WO2020112411A3 true WO2020112411A3 (en) 2020-08-20

Family

ID=68916561

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2019/062012 WO2020112411A2 (en) 2018-11-30 2019-11-18 System for continuous purification of biochemical mixtures

Country Status (1)

Country Link
WO (1) WO2020112411A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170045483A1 (en) * 2014-04-23 2017-02-16 Oleg Shinkazh High efficiency continuous countercurrent tangential chromatography

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170045483A1 (en) * 2014-04-23 2017-02-16 Oleg Shinkazh High efficiency continuous countercurrent tangential chromatography

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
AMIT K. DUTTA ET AL: "Performance optimization of continuous countercurrent tangential chromatography for antibody capture", BIOTECHNOLOGY PROGRESS, vol. 32, no. 2, 1 March 2016 (2016-03-01), pages 430 - 439, XP055666229, ISSN: 8756-7938, DOI: 10.1002/btpr.2250 *
ERNO PUNGOR ET AL: "1987 Nature Publishing Group http://www.nature.com/naturebiotechnology @BULLET CONTINUOUS AFFINITY-RECYCLE EXTRAfflON: A NOVEL PROTEIN SEPARATION TECHNIQUE", 30 June 1987 (1987-06-30), XP055666011, Retrieved from the Internet <URL:https://www.nature.com/articles/nbt0687-604.pdf?proof=true> [retrieved on 20200206] *
GORDON N F ET AL: "AN OVERVIEW OF CONTINUOUS PROTEIN PURIFICATION PROCESSES", BIOTECHNOLOGY ADVANCES, ELSEVIER PUBLISHING, BARKING, GB, vol. 8, 1 January 1990 (1990-01-01), pages 741 - 762, XP000601595, ISSN: 0734-9750, DOI: 10.1016/0734-9750(90)91995-S *
S LABORIE ET AL: "Flux Enhancement bv a Continuous Tangential Gas Flow in Ultrafiltra- tion Hollow Fibres for Drinking Water Production: Effects of Slug Flow on Cake Structure", 30 May 1996 (1996-05-30), XP055666234, Retrieved from the Internet <URL:https://www.sciencedirect.com/science/article/pii/S0015188297814139> [retrieved on 20200207] *
Y. WIBISONO ET AL: "Two-phase flow in membrane processes: A technology with a future", JOURNAL OF MEMBRANE SCIENCE, vol. 453, 1 March 2014 (2014-03-01), NL, pages 566 - 602, XP055666211, ISSN: 0376-7388, DOI: 10.1016/j.memsci.2013.10.072 *

Also Published As

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