WO2020100693A1 - Heat exchanger - Google Patents
Heat exchanger Download PDFInfo
- Publication number
- WO2020100693A1 WO2020100693A1 PCT/JP2019/043552 JP2019043552W WO2020100693A1 WO 2020100693 A1 WO2020100693 A1 WO 2020100693A1 JP 2019043552 W JP2019043552 W JP 2019043552W WO 2020100693 A1 WO2020100693 A1 WO 2020100693A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- liquid chamber
- temperature
- filter
- heat exchanger
- port
- Prior art date
Links
- 239000012530 fluid Substances 0.000 claims abstract description 47
- 239000007788 liquid Substances 0.000 claims description 262
- 238000007872 degassing Methods 0.000 claims description 74
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- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 2
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3623—Means for actively controlling temperature of blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
Definitions
- the present invention relates to a medical heat exchanger used for controlling the temperature of circulating fluid such as myocardial protection fluid and blood during surgery under cardiac arrest.
- a means for cooling the myocardium for example, it is generally performed to cool the myocardium by lowering the temperature of circulating fluid such as blood or drug solution (for example, cardioplegic solution) and sending it to the coronary arteries of the heart.
- circulating fluid such as blood or drug solution (for example, cardioplegic solution)
- the temperature of the circulating fluid is controlled (cooled) by a heat exchanger connected to the coronary arteries of the heart.
- the heat exchanger is, for example, like the medical heat exchanger (1) described in Japanese Patent No. 3742711 (Patent Document 1), the temperature of the circulating liquid by heat exchange between the circulating liquid and the heat exchange medium.
- a bubble-trapping filter member (16) is provided in the biological circulation liquid circulation chamber (13) into which the temperature-controlled circulating liquid flows. Then, the circulating fluid that has passed through the bubble trapping filter member is fed into the body lumen (blood vessel) of the patient, whereby the myocardium is cooled by the circulating fluid.
- the present invention has been made in view of the above circumstances, and a problem to be solved is to provide a heat exchanger having a novel structure capable of efficiently removing bubbles in a circulating liquid. is there.
- the first aspect of the present invention is a heat exchanger including a heat exchange unit that adjusts the temperature of the circulating liquid, wherein the temperature-adjusted liquid into which the circulating liquid whose temperature has been adjusted in the heat exchange unit flows.
- a chamber is provided, a filter for removing air in the circulating liquid is arranged in the temperature-adjusted liquid chamber, and a deaeration port is provided on the wall of the temperature-adjusted liquid chamber.
- the filter is provided so as to be inclined toward the deaeration port.
- the filter that allows the passage of the circulating liquid and restricts the passage of the air mixed with the circulating liquid is inclined toward the opening of the degassing port.
- the air filtered by the filter is guided to the deaeration port by floating along the filter.
- a second aspect of the present invention is the heat exchanger according to the first aspect, wherein the temperature-adjusted liquid chamber has a pre-degassing liquid chamber and a post-degassing liquid chamber on both sides of the filter.
- the degassing port is provided on the wall of the pre-degassing liquid chamber.
- the degassing port is provided in the wall portion of the pre-degassing liquid chamber, the degassing port is provided in the post-degassing liquid chamber. In comparison, it is possible to prevent air bubbles from entering the body and efficiently remove the air mixed with the circulating fluid.
- a third aspect of the present invention is the heat exchanger according to the first or second aspect, in which the filter is insert-molded into a housing forming a wall of the temperature-adjusted liquid chamber. It is said that.
- the filter is directly attached to the housing by insert molding, so that a separate member for fixing the filter to the housing is not required, and the number of parts is reduced. And the structure can be simplified.
- a fourth aspect of the present invention is the heat exchanger according to any one of the first to third aspects, wherein the temperature detection port for measuring the temperature in the liquid chamber after temperature adjustment is the temperature adjustment port. It is provided on the wall of the rear liquid chamber.
- the heat exchanger configured according to the present aspect, for example, when the temperature detection port itself projects into the liquid chamber after temperature adjustment, or a temperature sensor inserted into the temperature detection port projects into the liquid chamber after temperature adjustment. In this case, the problem that air bubbles are caught in the temperature detection port or the temperature sensor and remain will not easily occur.
- a fifth aspect of the present invention is the heat exchanger according to any one of the first to fourth aspects, wherein at least the root portion of the degassing port is transparent.
- the heat exchanger having the structure according to this aspect, it is possible to visually check the inside of the deaeration port from the outside, for example, after visually confirming the state where the air is accumulated in the deaeration port. It is also possible to discharge air to the outside by opening the opening / closing valve of the degassing port.
- a sixth aspect of the present invention is the heat exchanger according to any one of the first to fifth aspects, in which the filter has a flat shape.
- the heat exchanger having the structure according to this aspect, bubbles are efficiently guided to the degassing port without being caught in the filter. Moreover, even if the filter has a flat shape, it is possible to secure a sufficient filter area by providing the filter in a slanted manner, and secure the required flow rate of the circulating liquid while effectively removing air. be able to.
- a seventh aspect of the present invention is the heat exchanger according to any one of the first to sixth aspects, in which the filter is made of a hydrophobic material.
- the bubbles are easily moved along the filter, so that the bubbles are efficiently guided to the degassing port, so that the air discharge efficiency is improved.
- An eighth aspect of the present invention is the heat exchanger according to any one of the first to sixth aspects, in which the filter is made of a hydrophilic material.
- the circulating liquid can more easily pass through the filter.
- a ninth aspect of the present invention is a heat exchanger including a heat exchange part for adjusting the temperature of the circulating liquid, wherein the temperature-adjusted liquid into which the circulating liquid whose temperature has been adjusted in the heat exchange part flows.
- a chamber is provided, and a filter for removing air in the circulating liquid is disposed in the post-temperature-controlling liquid chamber, and both sides of the filter in the post-temperature-controlling liquid chamber are separated from the pre-degassing liquid chamber.
- the filter is an after-effect liquid chamber, and the filter is an insert component member that is insert-molded into a housing that forms a wall portion of the temperature-adjusted liquid chamber.
- the filter is directly attached to the housing by insert molding, so that a separate member for fixing the filter to the housing is not required, and the number of parts is reduced. And the structure can be simplified.
- a tenth aspect of the present invention is the heat exchanger according to the ninth aspect, wherein the housing constitutes a wall portion of the pre-degassing liquid chamber and the post-degassing liquid.
- a second liquid chamber wall member constituting a wall portion of the chamber, and the filter is attached to the first liquid chamber wall member of the housing.
- the first liquid chamber wall member is provided with an opening connected to, for example, a heat exchange section, so that even if the filter is insert-molded, the mold can be formed after the molding. It is easy to remove and the housing with the filter is easily manufactured.
- An eleventh aspect of the present invention is the heat exchanger according to any one of the first to tenth aspects, wherein the circulating liquid is communicated with the heat exchange section and introduces the circulating liquid into the heat exchange section.
- a bottom member having an inlet port is provided, and a part of the bottom member facing the opening of the circulating liquid inlet port is provided with a flow dividing projection protruding toward the circulating liquid inlet port, Guide ridges extending in the circumferential direction of the bottom member are provided on both sides of the flow dividing projection in the circumferential direction of the bottom member.
- the circulating liquid introduced from the circulating liquid inlet port to the inside of the bottom member is divided into both sides of the flow dividing protrusion by contacting the flow dividing protrusion, and the guide protrusions are provided.
- the flow of the circulating liquid is divided into both sides in the circumferential direction by the flow dividing projections, the flow of the circulating liquid flows more smoothly inside the bottom member than in the case where there is no flow dividing protrusion, and thus the flow velocity of the circulating liquid decreases. For example, pressure loss is reduced. Therefore, the circulating liquid flowing from the circulating liquid inlet port to the inside of the bottom member smoothly flows to the heat exchanging portion, and the circulating liquid is efficiently supplied to the heat exchanging portion.
- FIG. 1 The perspective view which shows the heat exchanger as the 1st Embodiment of this invention.
- Bottom view of the heat exchanger shown in FIG. VI-VI sectional view of FIG. VII-VII sectional view of FIG. 1 is a perspective view of a bottom member constituting the heat exchanger shown in FIG.
- An enlarged plan view of the bottom member shown in FIG. FIG. 10 is a cross-sectional view of the bottom member shown in FIG. 9, corresponding to the XX cross section of FIG. 9.
- the figure which expands and shows the principal part of the heat exchanger shown in FIG. 1 is a perspective view of a second liquid chamber wall member that constitutes the heat exchanger shown in FIG. Enlarged sectional view of the second liquid chamber wall member shown in FIG.
- the heat exchanger 10 is a surface heat exchanger in which the circulating liquid and the heat exchange medium are indirectly in contact with each other to exchange heat.
- the heat exchange section 14 is housed in the housing 12. It has a different structure.
- the vertical direction means the vertical direction in FIG. 2, which is the vertical vertical direction in principle.
- the housing 12 is formed of a hard synthetic resin, and has a generally cylindrical housing body 16, a bottom member 18 that closes an opening on the lower side of the housing body 16, and a housing body 16. It is constituted by a lid member 20 that closes the upper opening.
- the material for forming the housing 12 is not particularly limited, and may be metal or glass, but is preferably made of a synthetic resin such as polycarbonate or acrylic resin. It is desirable that the space is transparent or translucent so that the space can be visually confirmed. Further, the entire housing 12 does not need to be formed of the same material, and for example, the housing body 16, the bottom member 18, and the lid member 20 may be formed of different materials.
- the housing main body 16 integrally includes a cylindrical housing tubular portion 22, and a heat exchange medium inlet port 24 and a heat exchange medium outlet port 26 that are connected to the peripheral wall portion of the housing tubular portion 22.
- a heat exchange medium inlet port 24 and a heat exchange medium outlet port 26 are provided on the peripheral wall portion of the accommodating cylinder portion 22 as connection portions connected to an external device such as a blood reservoir.
- Each of the heat exchange medium inlet port 24 and the heat exchange medium outlet port 26 has a substantially cylindrical shape, and extends from the lower portion of the storage tubular portion 22 toward both sides in the radial direction of the storage tubular portion 22, and Inclined toward the tip side.
- both the inner cavity of the heat exchange medium inlet port 24 and the inner cavity of the heat exchange medium outlet port 26 are communicated with the inner cavity of the housing tubular portion 22.
- the housing cylinder portion 22 is not limited to a cylindrical shape, and may be an elliptic cylinder shape, a polygonal cylinder shape, a deformed cylinder shape, or the like.
- the heat exchange medium inlet port 24 and the heat exchange medium outlet port 26 are not limited to the cylindrical shape, and may be an elliptic cylinder shape, a polygonal cylinder shape, a deformed cylinder shape, or the like.
- the heat exchange medium inlet port 24 and the heat exchange medium outlet port 26 may be provided separately from the housing body 16.
- heat exchange medium inlet port 24 and the heat exchange medium outlet port 26 may be provided in mutually interchanged positions. Further, the heat exchange medium inlet port 24 and the heat exchange medium outlet port 26 may be provided by being formed separately from the housing tubular portion 22 and attached to the peripheral wall portion of the housing tubular portion 22.
- the bottom member 18 has a substantially disk shape or a bottomed cylindrical shape, and the outer peripheral portion is liquid-tightly fixed to the lower end portion of the housing body 16 over the entire circumference.
- the protrusion projecting from the bottom member 18 toward the housing tubular portion 22 of the housing body 16 is fitted and fixed to the recess opening in the lower end surface of the housing tubular portion 22.
- the bottom member 18 is provided with a circulating liquid inlet port 30.
- the circulating liquid inlet port 30 has a substantially cylindrical shape and extends forward (leftward in FIG. 7) from the bottom member 18, and when the bottom member 18 is attached to the housing body 16, the circulating liquid inlet port 30 is provided.
- the inner cavity of 30 communicates with the inner cavity of the housing cylinder portion 22 of the housing body 16.
- the bottom member 18 is provided with a drug solution administration port 32.
- the drug solution administration port 32 extends obliquely downward from the bottom wall portion of the bottom member 18 while inclining forward, and when the bottom member 18 is attached to the housing body 16, the inner cavity of the drug solution administration port 32. Is communicated with the inner cavity of the housing cylinder portion 22 of the housing body 16. Note that in FIG. 7, the drug solution administration port 32 is closed by a removable cap 34.
- the bottom member 18 includes a groove portion 36 that extends radially from the opening of the circulating fluid inlet port 30.
- the groove portion 36 is open to the upper surface of the bottom wall portion of the bottom member 18, and bottom upper portions 38 located above the bottom surface of the groove portion 36 are provided on both sides in the width direction of the groove portion 36, respectively.
- the depth dimension from the upper end of the peripheral wall of the bottom member 18 is larger in the groove portion 36 than in the bottom upper portions 38, 38 which are out of the groove portion 36.
- the position of the bottom surface of the groove portion 36 in the vertical direction is substantially constant in the length direction.
- the upper surface of the bottom upper portion 38 is inclined downward as it goes away from the circulating liquid inlet port 30. Therefore, the depth of the groove 36 from the bottom upper portion 38 becomes smaller as the distance from the circulating liquid inlet port 30 increases.
- the circulating fluid inlet port 30 is opened at one end of the groove 36, and the flow dividing projection 40 is provided at the other end of the groove 36.
- the flow dividing projection 40 projects in the longitudinal direction of the groove 36 toward the circulating liquid inlet port 30 at a portion of the peripheral wall portion of the bottom member 18 facing the opening of the circulating liquid inlet port 30.
- the width dimension of the flow dividing projection 40 in the circumferential direction of the bottom member 18 gradually decreases toward the tip.
- the tip end portion has a convex curved shape toward the outside (projecting tip end side), and the base end portion has a concave curved shape toward the outside (both circumferential directions).
- the lower end of the flow dividing projection 40 is continuous with the bottom surface of the groove portion 36 of the bottom member 18, and the upper end of the flow dividing projection 40 reaches the upper side of the bottom upper portions 38, 38.
- Guide ridges 42 are provided on the upper portions 38, 38 of the bottom, respectively.
- the guide ridges 42 are ridges that project upward from the upper surface of the bottom upper portion 38, respectively, and extend in predetermined directions in the circumferential direction of the bottom member 18 from both sides of the flow dividing projection 40 toward the circulating liquid inlet port 30 side. It extends in length.
- One end of the guide ridge 42 in the circumferential direction is located apart from the flow dividing projection 40 in the circumferential direction, and the other end of the guide ridge 42 in the circumferential direction is an opening of the circulating fluid inlet port 30. It is located in the circumferential direction with respect to.
- the guide ridges 42 are provided so as to face the inner surface of the peripheral wall of the bottom member 18 while being spaced apart from each other on the inner peripheral side. Since the upper surface of the bottom upper part 38 is inclined downward toward the diversion projection 40 side, and the upper end of the guide protrusion 42 extends substantially perpendicular to the vertical direction, The projecting height dimension gradually decreases from the flow dividing projection 40 side toward the circulating liquid inlet port 30 side. The circulating liquid flows into the bottom member 18 from the circulating liquid inlet port 30, collides with the flow dividing projection 40, then flows along the guide protrusion 42, and is guided to the circulating liquid inlet port 30 side.
- the upper surface of the guide ridge 42 is located at substantially the same height as the upper surface of the flow dividing projection 40 in the vertical direction.
- the lid member 20 has a bottomed cylindrical shape that is turned upside down as a whole, and in this embodiment, is divided into upper and lower wall portions and a peripheral wall portion that are fixed to each other. It is composed of two members. That is, the lid member 20 of the present embodiment includes the first liquid chamber wall member 44 fixed to the upper end portion of the housing body 16 and the second liquid chamber wall member fixed to the first liquid chamber wall member 44. And 46.
- the lower end of the first liquid chamber wall member 44 is fixed to the upper end of the housing body 16 by means such as welding, and the first liquid chamber wall member 44 opens obliquely upward at the front (left in FIG. 11).
- An inclined opening 48 is provided.
- the periphery of the inclined opening portion 48 is a flat surface that is inclined rearward toward the upper side.
- the upper wall portion of the first liquid chamber wall member 44 is provided with a substantially cylindrical degassing port 50, and the lower opening 52 of the degassing port 50 has a first liquid chamber wall member. It is formed on the inner wall surface of the upper side of 44, and the inner cavity of the degassing port 50 communicates with the internal space of the first liquid chamber wall member 44 (pre-degassing liquid chamber 80 described later).
- the peripheral portion of the opening 52 of the degassing port 50 may include a tapered portion such as a curved surface shape or an inclined flat surface shape that gradually expands downward.
- the guide of bubbles to the degassing port 50 described later is efficiently realized not only by the filter 78 described below, but also by the tapered shape of the opening peripheral edge portion of the degassing port 50.
- the tapered surface may be provided up to a position continuous with the filter 78 described later, or the filter may be provided through a plane substantially orthogonal to the vertical direction.
- a tapered surface may be provided at a position away from 78.
- the degassing port 50 is closed by a removable cap 54.
- a substantially cylindrical pressure detection port 56 is provided on the peripheral wall portion of the first liquid chamber wall member 44, and the inner cavity of the pressure detection port 56 is the first liquid.
- a male screw is provided on the outer peripheral surface of the pressure detection port 56 while communicating with the internal space of the chamber wall member 44.
- the pressure detection port 56 may be attached with a cap having a female screw corresponding to the male screw on the outer peripheral surface of the pressure detection port 56.
- the lid member 20 it is preferable that at least the base end portion (root portion) of the degassing port 50 is made transparent so that the internal space can be visually confirmed from the outside. .
- the entire housing 12 is transparent, but the housing body 16, the bottom member 18, and the lid member 20 may be opaque.
- the lid member 20 may be subjected to embossing.
- the first liquid chamber wall member 44 may be made transparent, and the second liquid chamber wall member 46 may be made opaque.
- the second liquid chamber wall member 46 includes a circulating fluid outlet port 58 having a substantially cylindrical shape that extends forward, and the inner cavity of the circulating fluid outlet port 58 is the second. It communicates with the internal space of the liquid chamber wall member 46. Furthermore, the temperature detecting port 60 is provided in the second liquid chamber wall member 46, and the temperature detecting member 62 is provided in the temperature detecting port 60 in an inserted state. In the temperature detecting member 62, a tubular base 64 is fixed to the second liquid chamber wall member 46 at the temperature detecting port 60, and a test tube-shaped tip 66 is passed through the temperature detecting port 60 and the degassed liquid to be described later. It is inserted into the chamber 82, and the temperature of the circulating liquid in the liquid chamber 82 after deaeration can be measured.
- the second liquid chamber wall member 46 is provided so as to close the inclined opening portion 48 of the first liquid chamber wall member 44, and the second liquid chamber wall member 46 serves as the first liquid chamber wall member 44.
- the lid member 20 is formed by being liquid-tightly fixed.
- the projection provided on the inclined opening portion 48 of the first liquid chamber wall member 44 is fitted and fixed to the concave portion provided on the second liquid chamber wall member 46.
- the lower end portion of the lid member 20, which is constituted by the first liquid chamber wall member 44, is liquid-tightly fixed to the upper end portion of the housing body 16.
- the projection provided on the lower end of the first liquid chamber wall member 44 is fitted and fixed to the recess opening on the upper end surface of the housing body 16.
- the bottom member 18 is attached so as to cover the lower side of the housing cylindrical portion 22 in the housing body 16, and the lid member 20 is attached so as to cover the upper side of the housing cylindrical portion 22.
- the hollow housing 12 is composed of a housing body 16, a bottom member 18, and a lid member 20.
- the temperature detection port 60 and the pressure detection port 56 are all in communication with the internal space of the housing 12.
- the heat exchange section 14 is housed in the internal space of the housing 12 having such a structure.
- the heat exchange section 14 includes a plurality of heat transfer tubes 68, as shown in FIGS.
- the heat transfer tube 68 has an elongated small-diameter cylindrical shape, and is preferably formed of a material having excellent corrosion resistance to a circulating fluid and a heat exchange medium described later and having a large thermal conductivity.
- a material having excellent corrosion resistance to a circulating fluid and a heat exchange medium described later having a large thermal conductivity.
- copper or aluminum It is formed of iron (stainless steel) or an alloy thereof.
- the heat transfer tube 68 of the present embodiment extends linearly in the vertical direction, it is possible to prevent air from remaining in the lumen of the heat transfer tube 68 and to disturb the circulating fluid flowing through the lumen of the heat transfer tube 68. The flow is being reduced.
- the heat transfer tube 68 is not limited to a linear tubular shape, and can be appropriately curved, for example, to obtain a large contact area with a heat exchange medium described later to improve the efficiency of heat exchange. ..
- the cross-sectional shape, number, arrangement, etc. of the heat transfer tubes 68 are not limited to any one, and may be, for example, an elliptic cylinder shape, a polygonal cylinder shape, or a deformed cylinder shape.
- fins may be provided on the outer peripheral surface of the heat transfer tube 68 to improve the efficiency of heat exchange.
- the heat transfer tubes 68 are arranged as a tube group in which a plurality of heat transfer tubes 68 are bundled in a substantially columnar shape, and the lower end portions of the plurality of heat transfer tubes 68 are positioned relative to each other by a lower support plate 70 formed of urethane or the like.
- the upper end portions are mutually positioned by the upper support plate 72 formed of urethane or the like.
- Each of the lower support plate 70 and the upper support plate 72 is a substantially disc-shaped member formed of a synthetic resin or the like, and liquid-tightly closes the space between the plurality of heat transfer pipes 68 in the tube group. It projects to the outer periphery of the group and is fixed to the housing body 16.
- the support plates 70 and 72 may be formed into a shape having an insertion hole for the heat transfer tube 68, and then the heat transfer tube 68 may be inserted into the insertion hole and adhered thereto. While being set on the inner circumference of the housing 22, the inner circumference of both axial ends of the housing cylinder 22 is filled with a potting resin to be molded, so that the heat transfer tube 68 and the housing cylinder 22 are fixedly formed. You can also
- the lower support plate 70 is fixed to the lower end portion of the housing tubular portion 22, and the upper support plate 72 is fixed to the upper end portion of the housing tubular portion 22, so that the plurality of heat transfer tubes 68 are arranged in the housing tubular portion 22. It is supported so as to extend vertically in the inner circumference.
- the heat transfer tube 68 has a lower opening communicating with the circulating liquid inlet port 30 and the chemical liquid administration port 32 through the internal space of the bottom member 18, and an upper opening through the internal space of the lid member 20. And the deaeration port 50.
- the inner peripheral surface of the housing tubular portion 22 of the housing body 16 gradually contracts upward, and in the present embodiment, has a tapered shape with a gradually decreasing diameter. Thereby, the distance between the facing surfaces of the inner peripheral surface of the housing tubular portion 22 and the outer peripheral surface of the tube group including the plurality of heat transfer tubes 68 becomes smaller as it goes upward.
- the heat exchange medium inlet port 24 and the heat exchange medium outlet port 26 are communicated with each other through the plurality of heat transfer tubes 68, and the space between the heat transfer tubes 68 has a bottom member 18 and a lid member 20.
- the inner spaces are liquid-tightly separated by the support plates 70 and 72.
- the pre-temperature-controlling liquid chamber 74 is configured by the internal space of the bottom member 18, the circulating liquid inlet port 30 and the chemical liquid administration port 32 are communicated with each other, and the lower ends of the inner cavities of the plurality of heat transfer tubes 68 are communicated with each other. Has been done.
- the temperature-adjusted liquid chamber 76 is constituted by the internal space of the lid member 20, and the deaeration port 50, the pressure detection port 56, the circulating liquid outlet port 58, and the temperature detection port 60 are connected to each other, and a plurality of them are provided.
- the lumens of the heat transfer tube 68 communicate with each other.
- the temperature detecting member 62 inserted into the temperature detecting port 60 has a tip portion 66 protruding into the liquid chamber 76 after temperature adjustment.
- a filter 78 is arranged in the temperature-adjusted liquid chamber 76.
- the filter 78 is a polymer film that allows passage of the circulating liquid and restricts the passage of air.
- the filter 78 has a flat membrane shape and is tilted up and down in the liquid chamber 76 after temperature adjustment. It is arranged in a stretched state so as to spread. More specifically, as shown in FIG. 11, the filter 78 is provided so as to close the inclined opening portion 48 of the first liquid chamber wall member 44, and the opening of the degassing port 50 from the bottom to the top. It is inclined and spreads backward (to the right in FIG. 11) so as to approach 52.
- the filter 78 is fixedly supported by the wall portion that defines the temperature-adjusted liquid chamber 76 at the entire peripheral edge thereof, and particularly, the lower end portion is supported by the lower portion of the cylindrical peripheral wall of the temperature-adjusted liquid chamber 76. In addition to being supported, the upper end portion is supported by the wall portion of the upper bottom of the liquid chamber 76 after temperature adjustment. Note that, in FIGS. 7 and 11, the thickness of the filter 78 is illustrated thicker than it actually is for the sake of easy viewing.
- the filter 78 of the present embodiment is set in the mold of the first liquid chamber wall member 44 in advance and insert-molded when the first liquid chamber wall member 44 is molded. It is an insert constituent member that constitutes the insert molded article.
- the filter 78 is fixedly attached to the first liquid chamber wall member 44 in a state where the peripheral edge of the filter 78 is welded or inserted inside, and is integrally attached.
- the outer peripheral edge of the filter 78 is directly fixed to the opening peripheral edge portion of the inclined opening portion 48 of the first liquid chamber wall member 44 constituting the housing 12 over the entire circumference.
- the material for forming the filter 78 is not particularly limited, but is preferably formed of a hydrophobic polymer material such as polyester, polyamide, polyolefin, or fluororesin.
- a hydrophobic polymer material such as polyester, polyamide, polyolefin, or fluororesin.
- the filter 78 may be made of a hydrophilic polymer material, and if the filter 78 is made of a hydrophilic material, the circulating liquid can easily pass through the filter 78.
- the filter 78 can also appropriately have both hydrophilicity and hydrophobicity depending on the required performance.
- the temperature-adjusted liquid chamber 76 is divided into two parts on both sides of the filter 78 by disposing the filter 78 in the temperature-adjusted liquid chamber 76. That is, in the rear of the filter 78, the pre-degassing liquid chamber 80 in which the plurality of heat transfer pipes 68, the degassing port 50, and the pressure detection port 56 communicate with each other is formed, while in front of the filter 78, the circulation is performed.
- a post-degassing liquid chamber 82 is formed in which the liquid outlet port 58 and the temperature detection port 60 communicate with each other.
- the wall portion of the pre-degassing liquid chamber 80 and the degassing port 50 are integrally formed in the first liquid chamber wall member 44, and the wall portion of the post-degassing liquid chamber 82.
- the circulating liquid outlet port 58 is integrally formed in the second liquid chamber wall member 46.
- the pressure in the pre-degassing liquid chamber 80 can be measured by a pressure sensor (not shown) by the pressure detection port 56, and the temperature in the post-degassing liquid chamber 82 can be measured by the temperature detection port 60 including the temperature detection member 62. Can be measured.
- the circulating fluid inlet port 30 and the circulating fluid outlet port 58 are connected to an extracorporeal circulation circuit (not shown), and the heat exchange medium inlet port 24 and the heat exchange medium outlet are provided. It is used with the port 26 connected to a heat exchange medium circulation circuit (not shown).
- the extracorporeal circulation circuit aims to supply oxygen and prevent myocardial damage by circulating blood and administering cardioplegic solution to patients in cardiac arrest.
- the extracorporeal circulation circuit of the present embodiment includes a circuit incorporating an artificial lung for temporarily replacing the functions of the heart and lungs, a heat exchanger, a blood pump, and a circuit for injecting a cardioplegic solution into the heart.
- a crystalline cardioplegic solution, blood, a blood-added cardioplegic solution in which blood is mixed with a crystalline cardioplegic solution, and the like are preferably used.
- the composition of the crystalline cardioplegic solution is not particularly limited, it is generally a high potassium solution and carries oxygen required for cardioplegia.
- the heat exchanger 10 for the myocardial protection circuit is exemplified, but the heat exchanger according to the present invention is not necessarily used only for the myocardial protection circuit, and for example, a patient is placed in a hypothermic state. It can also be applied to a heat exchanger for an artificial heart-lung circuit used when performing heat treatment.
- the heat exchange medium circulation circuit includes a pump for circulating the heat exchange medium and a temperature control device for cooling or heating the heat exchange medium.
- the heat exchange medium may be any fluid that can flow through the heat exchange medium circulation circuit, but a liquid such as water is preferably used.
- a priming process is performed. That is, by filling the circulating fluid inlet port 30 to the circulating fluid outlet port 58 with the circulating fluid, the circulating fluid inlet port 30, the medicinal solution administration port 32, the pre-temperature regulating liquid chamber 74, and the plurality of circulating fluid inlet ports 30 located on the circulating path of the circulating fluid are provided.
- the heat transfer pipe 68, the temperature-adjusted liquid chamber 76, the circulating liquid outlet port 58, the degassing port 50, and the pressure detection port 56 are filled with the circulating liquid to discharge the air.
- the air flows from the degassing port 50 to the outside until the pre-degassing liquid chamber 80 is filled with the circulating liquid. Is discharged. Further, the air mixed in the circulating fluid filling the pre-degassing liquid chamber 80 is filtered out by the filter 78, becomes air bubbles and floats up along the filter 78, so that the air above the pre-degassing liquid chamber 80 is removed. It is discharged to the outside from the deaeration port 50 provided on the wall.
- the air in the post-degassing liquid chamber 82 is discharged from the circulating liquid outlet port 58 to an extracorporeal circulation circuit (not shown), and is provided in the extracorporeal circulation circuit.
- the air trap is discharged to the outside of the circulation circuit. 7 and 11, the cap 54 is attached to the deaeration port 50, but the cap 54 is removed when performing the priming process, and a tube or the like (not shown) is connected to the deaeration port 50.
- the priming process is performed in.
- the pressure detection port 56 is liquid-tightly sealed when a pressure sensor (not shown) is inserted or when the pressure sensor is not inserted.
- the filter 78 is inclined toward the degassing port 50, and more specifically, is provided so as to be inclined upward so as to approach the opening 52 of the degassing port 50, The bubbles floating along the filter 78 are guided to the degassing port 50, and the air is efficiently discharged from the degassing port 50 to the outside. Therefore, it is difficult for the air to remain in the pre-degassing liquid chamber 80 after the priming process, and the removal of the air in the circulating liquid can be effectively realized.
- the circulating liquid in the pre-degassing liquid chamber 80 which may contain bubbles, comes into contact with the lower surface of the obliquely arranged filter 78, the bubbles removed from the circulating liquid by the filter 78 are buoyant. Thus, it floats along the filter 78. Therefore, it is possible to stably guide the bubbles to the degassing port 50.
- the filter 78 since the filter 78 has a flat shape, the bubbles are efficiently guided in the direction parallel to the surface of the filter 78 and guided to the degassing port 50. Moreover, since the filter 78 is arranged obliquely, it is possible to secure a large area of the filter 78 even if the filter 78 has a flat shape, and it is possible to obtain a large flow rate of the circulating liquid passing through the filter 78. You can
- the filter 78 is directly fixed to the first liquid chamber wall member 44 of the housing 12 by insert molding, the filter 78 is indirectly attached to the first liquid chamber wall member 44 via another member. Compared with the case, it is more difficult to form a step or unevenness in the mounting portion of the filter 78 on the inner surface of the wall of the first liquid chamber wall member 44. Therefore, it is difficult for the air to remain after the completion of the priming process, and the efficient discharge of the air is realized. In addition, steps or irregularities are unlikely to be formed in the mounting portion of the filter 78 on the inner wall surface of the second liquid chamber wall member 46, and air is prevented from remaining after the priming process is completed.
- the flow of the circulating liquid flowing from the circulating liquid inlet port 30 to the inside of the bottom member 18 is smoothly guided to both sides in the circumferential direction without being blocked by the peripheral wall of the bottom member 18 which is substantially orthogonal to the flow. .. Therefore, entrainment of bubbles due to turbulent flow is unlikely to occur, and the inside of the bottom member 18 can be quickly filled with the circulating liquid.
- guide ridges 42, 42 extending in the circumferential direction from the flow dividing projection 40 toward the circulating liquid inlet port 30 are provided on both sides in the circumferential direction of the bottom member 18 with respect to the flow dividing projection 40.
- the flow of the circulating liquid divided into both sides in the circumferential direction by the flow dividing projection 40 is guided in the circumferential direction on the outer peripheral portion of the bottom member 18 by the guide projections 42, 42.
- the flow of the circulating liquid whose direction has been changed by the flow dividing projections 40 hardly collides with the flow of the circulating liquid flowing from the circulating liquid inlet port 30 and passing through the center of the bottom member 18, and thus the flow collides. Turbulent flow due to
- the circulating fluid inlet port 30 is open at the end surface of the groove 36, and is located below the upper surfaces of the bottom upper portions 38, 38. Therefore, the flow of the circulating liquid flowing in from the circulating liquid inlet port 30 and the flow of the circulating liquid flowing on the bottom upper portions 38, 38 guided by the guide protrusions 42, 42 are displaced from each other even in the vertical direction. They are formed and are hard to bump into each other.
- the outer peripheral portions where the guide ridges 42, 42 are provided are the bottom upper portions 38, 38 having a shallower depth than the groove portion 36, the flow of the circulating liquid divided by the flow dividing protrusions 40 is applied to the heat transfer pipe 68. Flow near the end opening. Therefore, the circulating liquid introduced into the bottom member 18 is easily guided to the inner cavity of the heat transfer tube 68, and the circulating liquid can be efficiently introduced into the heat exchange section 14.
- the bottom upper portion 38 gradually inclines from the side of the flow dividing projection 40 toward the side of the circulating liquid inlet port 30 and approaches the end opening of the heat transfer tube 68. Therefore, also on the circulating liquid inlet port 30 side, the circulating liquid flowing on the bottom upper portion 38 is effectively introduced into the inner cavity of the heat transfer tube 68.
- the temperature of the circulating fluid is adjusted by the heat exchanger 10, and the temperature-controlled circulating fluid is supplied to the extracorporeal circulation circuit. That is, the heat exchange medium introduced into the heat exchange medium inlet port 24 is discharged from the heat exchange medium outlet port 26 through the gap provided between the plurality of heat transfer tubes 68.
- the circulating liquid that has entered the heat exchanger 10 from the circulating liquid inlet port 30 is indirectly contacted with the heat exchange medium when passing through the inner cavity of the heat transfer pipe 68, and the heat transfer pipe is provided between the circulating liquid and the heat exchange medium. Heat exchange (transfer) via 68 occurs.
- the temperature of the circulating liquid is adjusted, and the circulating liquid whose temperature has been adjusted in the heat exchange section 14 flows into the temperature-adjusted liquid chamber 76 (pre-degassing liquid chamber 80).
- the temperature of the circulating liquid that has passed through the heat exchanger 10 is not particularly limited, but it is desirable that it be compatible with both cooling and heating. For example, by cooling the circulating fluid used in the cardiac arrest state, the myocardium is protected under cardiac arrest, and at the time of releasing cardiac arrest, the circulating fluid heated to the living body temperature is supplied to the patient, Can restore the normal metabolic function of the heart. When both cooling and heating are possible, the circulating liquid during cooling and the circulating liquid during heating may be the same as each other or may be different from each other.
- the heat exchange medium is introduced into the space on the inner peripheral side of the housing tubular portion 22 from the lower portion and discharged from the lower portion, so that the heat exchange medium does not easily flow to the upper portion of the housing tubular portion 22. Therefore, the inner peripheral surface of the accommodating cylinder portion 22 is formed into a taper shape having a smaller diameter toward the upper side, and the opposing surface between the inner peripheral surface of the accommodating cylinder portion 22 and the outer peripheral surface of the tube group including the plurality of heat transfer tubes 68. The distance is gradually decreasing upward. As a result, the heat exchange medium fed from the lower portion of the accommodating cylinder portion 22 is suppressed from decreasing in the flow velocity due to pressure loss, and easily flows to the upper portion of the accommodating cylinder portion 22. Therefore, the heat exchange medium flowing in from the heat exchange medium inlet port 24 is supplied to the entire heat exchange section 14, and the heat exchange efficiency between the circulating liquid and the heat exchange medium is improved.
- the circulating liquid introduced from the circulating liquid inlet port 30 to the heat exchange section 14 flows through the lumen of the heat transfer tube 68, and the heat exchange medium flows between the outer peripheral surfaces of the plurality of heat transfer tubes 68.
- the volume of the circulation region of the circulating liquid (the inner cavity of the heat transfer pipe 68) is made smaller than the volume of the flow region of the heat exchange medium (the gap between the plurality of heat transfer pipes 68). Therefore, the amount of the priming liquid remaining in the heat exchange unit 14 at the time of completion of the priming is reduced, and it is possible to suppress the dilution of blood by the priming liquid entering the body (blood vessel) of the patient from the extracorporeal circulation circuit.
- the drug solution can be appropriately administered from the drug solution administration port 32 to the circulating fluid.
- the cap 34 is attached to the drug solution administration port 32, but the cap 34 may be removed at the time of drug solution administration, or the cap may be previously removed and a tube (not shown) may be connected, and the tube may be removed.
- the drug solution administration port 32 may be blocked by clamping.
- the air mixed in the circulating fluid is removed by the filter 78 and collected in the degassing port 50 even in the use state after the priming of the heat exchanger 10 is completed.
- the deaeration port 50 is shut off after the priming is completed, and leakage of the circulating fluid from the deaeration port 50 is prevented.
- the state where the air is collected in the deaeration port 50 includes the deaeration port 50. Since the first liquid chamber wall member 44 is transparent, it can be visually confirmed from the outside. Therefore, when it is confirmed that the air has collected in the deaeration port 50, the air can be discharged to the outside by temporarily opening the deaeration port 50. Since the deaeration port 50 is blocked by clamping the tube connected to the deaeration port 50 after the completion of the priming process, when the air is exhausted while the heat exchanger 10 is in use, You can temporarily release the clamp.
- the temperature detection port 60 is provided on the wall portion of the post-degassing liquid chamber 82 filled with the circulating liquid from which air has been removed by the filter 78, and the temperature detection member 62 is used to remove the post-degassing liquid from the temperature detection port 60. Even if the bubbles are provided so as to project into the chamber 82, the bubbles do not adhere to the temperature detecting member 62 and remain in the liquid chamber.
- the flowing direction of the circulating liquid and the flowing direction of the heat exchanging medium in the heat exchanging section 14 are set to intersect with each other, but both the circulating liquid and the heat exchanging medium flow vertically.
- the flowing direction of the circulating liquid may be the same as the flowing direction of the heat exchange medium, or may be the opposite direction.
- the filter 78 is not limited to a flat shape, and may be, for example, a tapered cylindrical shape whose diameter decreases upward.
- the upper end of the filter 78 is arranged so as to surround the opening 52 of the degassing port 50, so that bubbles moving upward along the filter 78 are guided to the degassing port 50.
- the filter 78 may have a curved plate shape, a corrugated plate shape, a bent plate shape, or the like.
- the method of fixing the filter 78 to the housing body 16 is not limited to insert molding. Specifically, a method of adhering the filter 78 to the housing body 16 as a separate component from the housing body 16 can be mentioned.
- the entire housing 12 does not need to be transparent, and for example, only the lid member 20 forming the upper wall portion of the housing 12 may be transparent, or the degassing provided on the lid member 20 may be performed. Only the port 50 may be transparent. In order to confirm the presence or absence of air bubbles from the outside, it is desirable that at least the root portion of the degassing port 50 is transparent or translucent, and more preferably, the degassing port 50 and the pre-degassing liquid chamber 80. Although the first liquid chamber wall member 44 forming the wall portion is transparent or translucent, the entire housing 12 can be formed of an opaque material.
- the heat exchanger 10 may introduce the patient's blood into the circulating fluid passage in order to reduce the physical burden on the patient.
- the housing 12 may be provided with a service port connected to an external conduit for introducing blood into the flow path of the circulating fluid.
- the service port is provided at a position where blood can be mixed into the circulating fluid before passing through the filter 78, considering that air is mixed due to the connection with the external pipeline.
- the service port can be provided in the first liquid chamber wall member 44 of the bottom member 18 or the lid member 20, and for example, the pressure detection port 56 of the above-described embodiment can be used as the service port. it can.
- the blood reservoir that stores the blood introduced into the flow path of the circulating fluid can be attached to the outer peripheral surface of the housing cylinder portion 22 by the attachment protrusions 28 a and 28 b provided on the housing 12, for example.
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Abstract
Description
Claims (11)
- 循環液の温度を調節する熱交換部を備えた熱交換器であって、
前記熱交換部において温度調節された前記循環液が流入する調温後液室が設けられていると共に、該調温後液室には該循環液中の空気を除去するフィルタが配されて、該調温後液室の壁部には脱気ポートが設けられており、該フィルタが該脱気ポートへ向けて傾斜して設けられていることを特徴とする熱交換器。 A heat exchanger having a heat exchange section for adjusting the temperature of the circulating fluid,
A temperature-adjusted liquid chamber into which the temperature-controlled circulating liquid flows in is provided in the heat exchange section, and a filter for removing air in the circulating liquid is arranged in the temperature-controlled liquid chamber, A heat exchanger characterized in that a deaeration port is provided on a wall portion of the temperature-adjusted liquid chamber, and the filter is provided so as to be inclined toward the deaeration port. - 前記調温後液室は前記フィルタの両側が脱気前液室と脱気後液室とされており、前記脱気ポートが該脱気前液室の壁部に設けられている請求項1に記載の熱交換器。 The pre-degassing liquid chamber and the post-degassing liquid chamber are provided on both sides of the filter in the post-temperature regulating liquid chamber, and the degassing port is provided in a wall portion of the pre-degassing liquid chamber. The heat exchanger described in.
- 前記フィルタが、前記調温後液室の壁部を構成するハウジングにインサート成形されたインサート構成部材とされている請求項1又は2に記載の熱交換器。 The heat exchanger according to claim 1 or 2, wherein the filter is an insert component member that is insert-molded in a housing that forms a wall portion of the temperature-adjusted liquid chamber.
- 前記調温後液室内の温度を測定するための温度検出ポートが、前記調温後液室の壁部に設けられている請求項1~3の何れか1項に記載の熱交換器。 The heat exchanger according to any one of claims 1 to 3, wherein a temperature detection port for measuring the temperature in the temperature-adjusted liquid chamber is provided on the wall of the temperature-controlled liquid chamber.
- 前記脱気ポートの少なくとも根元部分が透明とされている請求項1~4の何れか1項に記載の熱交換器。 The heat exchanger according to any one of claims 1 to 4, wherein at least a root portion of the degassing port is transparent.
- 前記フィルタが平坦な形状とされている請求項1~5の何れか1項に記載の熱交換器。 The heat exchanger according to any one of claims 1 to 5, wherein the filter has a flat shape.
- 前記フィルタが疎水性材料で形成されている請求項1~6の何れか1項に記載の熱交換器。 The heat exchanger according to any one of claims 1 to 6, wherein the filter is made of a hydrophobic material.
- 前記フィルタが親水性材料で形成されている請求項1~6の何れか1項に記載の熱交換器。 The heat exchanger according to any one of claims 1 to 6, wherein the filter is made of a hydrophilic material.
- 循環液の温度を調節する熱交換部を備えた熱交換器であって、
前記熱交換部において温度調節された前記循環液が流入する調温後液室が設けられていると共に、該調温後液室には該循環液中の空気を除去するフィルタが配されて、該調温後液室における該フィルタの両側が脱気前液室と脱気後液室とされていると共に、該フィルタが該調温後液室の壁部を構成するハウジングにインサート成形されたインサート構成部材とされていることを特徴とする熱交換器。 A heat exchanger having a heat exchange section for adjusting the temperature of the circulating fluid,
A temperature-adjusted liquid chamber into which the temperature-controlled circulating liquid flows in is provided in the heat exchange section, and a filter for removing air in the circulating liquid is arranged in the temperature-controlled liquid chamber, Both sides of the filter in the temperature controlled liquid chamber are a pre-degassed liquid chamber and a post-degassed liquid chamber, and the filter is insert-molded in a housing forming a wall portion of the temperature controlled liquid chamber. A heat exchanger characterized by being an insert component. - 前記ハウジングが前記脱気前液室の壁部を構成する第1の液室壁部材と前記脱気後液室の壁部を構成する第2の液室壁部材とを備えており、前記フィルタが該ハウジングの該第1の液室壁部材に取り付けられている請求項9に記載の熱交換器。 The housing includes a first liquid chamber wall member that forms a wall portion of the pre-degassing liquid chamber, and a second liquid chamber wall member that forms a wall portion of the post-degassing liquid chamber, and the filter The heat exchanger according to claim 9, wherein is attached to the first liquid chamber wall member of the housing.
- 前記熱交換部に連通されて前記循環液を該熱交換部へ導入する循環液入口ポートを備えた底部材が設けられており、
該底部材における該循環液入口ポートの開口と対向する部分には、該循環液入口ポートに向けて突出する分流突起が設けられていると共に、
該分流突起に対する該底部材の周方向の両側には、該底部材の周方向に延びるガイド突条が設けられている請求項1~10の何れか1項に記載の熱交換器。 A bottom member is provided which is in communication with the heat exchange section and which has a circulating fluid inlet port for introducing the circulating fluid into the heat exchange section,
At a portion of the bottom member facing the opening of the circulating liquid inlet port, a flow dividing projection protruding toward the circulating liquid inlet port is provided, and
11. The heat exchanger according to claim 1, wherein guide ridges extending in the circumferential direction of the bottom member are provided on both sides of the bottom member in the circumferential direction with respect to the flow dividing projections.
Priority Applications (2)
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JP2020555557A JPWO2020100693A1 (en) | 2018-11-12 | 2019-11-06 | Heat exchanger |
BR112021007569-0A BR112021007569A2 (en) | 2018-11-12 | 2019-11-06 | heat exchanger |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000025843A1 (en) * | 1998-11-02 | 2000-05-11 | Lifestream International, Inc. | Cardioplegia heat exchanger |
JP2010200884A (en) * | 2009-03-02 | 2010-09-16 | Jms Co Ltd | Artificial lung device |
WO2011099610A1 (en) * | 2010-02-15 | 2011-08-18 | ニプロ株式会社 | Heat exchanger and heat exchanger-integrated artificial lung |
WO2012132110A1 (en) * | 2011-03-31 | 2012-10-04 | テルモ株式会社 | Artificial lung and extracorporeal circulation device |
-
2019
- 2019-11-06 WO PCT/JP2019/043552 patent/WO2020100693A1/en active Application Filing
- 2019-11-06 JP JP2020555557A patent/JPWO2020100693A1/en active Pending
- 2019-11-06 BR BR112021007569-0A patent/BR112021007569A2/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000025843A1 (en) * | 1998-11-02 | 2000-05-11 | Lifestream International, Inc. | Cardioplegia heat exchanger |
JP2010200884A (en) * | 2009-03-02 | 2010-09-16 | Jms Co Ltd | Artificial lung device |
WO2011099610A1 (en) * | 2010-02-15 | 2011-08-18 | ニプロ株式会社 | Heat exchanger and heat exchanger-integrated artificial lung |
WO2012132110A1 (en) * | 2011-03-31 | 2012-10-04 | テルモ株式会社 | Artificial lung and extracorporeal circulation device |
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