WO2020086332A1 - Adaptateur de seringue pour médicament - Google Patents

Adaptateur de seringue pour médicament Download PDF

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Publication number
WO2020086332A1
WO2020086332A1 PCT/US2019/056282 US2019056282W WO2020086332A1 WO 2020086332 A1 WO2020086332 A1 WO 2020086332A1 US 2019056282 W US2019056282 W US 2019056282W WO 2020086332 A1 WO2020086332 A1 WO 2020086332A1
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WO
WIPO (PCT)
Prior art keywords
syringe
syringe adapter
medication
distal end
needle
Prior art date
Application number
PCT/US2019/056282
Other languages
English (en)
Inventor
James T. DOUBET
Paul D. Doubet
Original Assignee
Doubet James T
Doubet Paul D
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US16/166,111 external-priority patent/US11097058B2/en
Application filed by Doubet James T, Doubet Paul D filed Critical Doubet James T
Priority to CA3110931A priority Critical patent/CA3110931A1/fr
Publication of WO2020086332A1 publication Critical patent/WO2020086332A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3114—Filling or refilling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M5/3137—Specially designed finger grip means, e.g. for easy manipulation of the syringe rod
    • A61M2005/3139—Finger grips not integrally formed with the syringe barrel, e.g. using adapter with finger grips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10—Tube connectors; Tube couplings
    • A61M2039/1077—Adapters, e.g. couplings adapting a connector to one or several other connectors

Definitions

  • the present invention relates to improved apparatus for use with medication, and method(s) of using same, particularly for higher-viscosity medication.
  • Medication is needed for various purposes, including illness treatment and illness prevention.
  • a syringe adapter for withdrawing fluid medication from a container comprises a sidewall extending between a proximal end and a distal end, the sidewall having an interior surface defining a chamber, the proximal end configured to be connected to a syringe while withdrawing at least a portion of the fluid medication from the container through the chamber and into a barrel of the syringe and the distal end configured for inserting into the container for the withdrawal, wherein an opening at the distal end is relatively large in diameter to facilitate withdrawing fluid medication having a relatively high viscosity and the syringe adapter is configured to be removed from the syringe and replaced with a needle prior to subsequently injecting (for example, info an animal) the fluid medication (or at least some portion thereof) withdrawn into the barrel.
  • the relatively large opening is
  • the syringe is preferably configured as a pistol-grip syringe or a tab-handled syringe, and may therefore provide improved leverage for the subsequent injection.
  • the diameter of the opening at the distal end is approximately 0.10 inches and the sidewall is approximately 0.05 inches in thickness at the distal end.
  • the syringe adapter further comprises a flanged area that extends perpendicularly from the proximal end.
  • the syringe adapter may further comprise a radial extension member that extends perpendicularly and radially outward from an exterior surface of the syringe adapter.
  • an outer shape of the syringe adapter is generally conical in a first portion and generally cylindrical in a second portion.
  • an inner shape of the syringe adapter, for at least a portion of the proximal end is generally conical.
  • the inner shape of the syringe adapter tapers from the proximal end toward the distal end, for at least a portion of the proximal end, at approximately 6 percent.
  • the syringe adapter preferably connects to the syringe using a Luer-type connection, the Luer-type connection selected from the group comprising a Luer-type lock and a Luer-type slip.
  • a method of administering fluid medication comprises: affixing a syringe adapter to a syringe, the syringe adapter comprising a sidewall extending between a proximal end and a distal end, the sidewall having an interior surface defining a chamber, the proximal end configured to be connected to a distal end of the syringe; inserting the distal end of the syringe adapter into a container of fluid medication having a relatively high viscosity;
  • the syringe adapter is configured for receiving a needle at its distal end, such that the needle is affixed to the distal end of the syringe adapter subsequent to withdrawing fluid medication into the barrel of the syringe, and the syringe adapter is configured to remain in place while injecting the fluid medication (or at least some portion thereof) into a recipient with the needle.
  • administering the fluid medication may be repeated (for example, for another recipient) by removing the needle, using the in-place syringe adapter for withdrawing more fluid medication (from the same or a different container), re-affixing the needle to the syringe adapter, and then injecting this medication (or some portion thereof).
  • the distal end of the syringe adapter preferably provides for a Luer-type connection with the needle, and the proximal end of the syringe adapter is preferably configured with a Luer-type locking member for connecting to the syringe.
  • the syringe adapter may further comprise an extension member that extends
  • a method of administering fluid medication comprises: affixing a syringe adapter to a syringe, the syringe adapter comprising a sidewall extending between a proximal end and a distal end and having an interior surface defining a chamber, the proximal end configured to be connected to a distal end of the syringe; inserting the distal end of the syringe adapter into a container of fluid medication having a relatively high viscosity; withdrawing, from the container, at least a portion of the fluid medication through the chamber and into a barrel of the syringe, wherein an opening at the distal end of the syringe adapter is relatively large in diameter to facilitate withdrawing the relafively-high-viscosity medication; affixing a needle to the distal end of the syringe adapter, subsequent to the withdrawing from the container; and injecting, into a recipient with the needle, at
  • a system for administering higher-viscosity fluid medication comprises: a syringe; a syringe adapter comprising a sidewall extending between a proximal end and a distal end, the sidewall having an interior surface defining a chamber, the proximal end configured to be connected to the syringe while withdrawing at least a portion of the fluid medication from a container through the chamber and into a barrel of the syringe and the distal end configured for inserting into the container for the withdrawal, wherein an opening at the distal end is relatively large in diameter to facilitate withdrawing the higher-viscosity fluid medication from the container; and a needle, the needle configured for connecting to the syringe adapter subsequent to use of the syringe adapter for the withdrawing and while the syringe adapter remains connected to the syringe, the needle further configured for injecting, into a recipient, at least a portion of the fluid medication withdrawn into the
  • FIGs. 1 - 3 depict examples of prior art syringes
  • FIG. 4 depicts an example of a prior art needle
  • FIGs. 4A and 4B illustrate bottom views showing how a proximal end of a needle may be configured for securable attachment to a syringe
  • FIGs. 5 - 6 illustrate first and second preferred embodiments of the syringe adapter disclosed herein;
  • FIGs. 7 ⁇ 8 illustrate alternative embodiments of the syringe adapter disclosed herein;
  • FIG. 9 illustrates a still further embodiment of the syringe adapter disclosed herein.
  • FIG. 10 illustrates a syringe adapter placed upon a syringe
  • FIG. 1 1 illustrates a needle placed upon a syringe adapter
  • F!Gs. 12 and 13 illustrate yet other embodiments of the syringe adapter disclosed herein, and also illustrate placement thereof upon a syringe;
  • FIG. 14 illustrates a further embodiment of the disclosed syringe adapter, showing an exterior view' as well as cross-sectional views of placement thereof upon a syringe and as exploded;
  • FIG. 15 presents tables containing measurements from tests conducted to compare use of a sample version of the disclosed syringe adapter to use of conventional needles.
  • Treatment of animals using medication may be desired whether the animal is a family pet, part of a livestock operation, is the subject of research, and so forth.
  • Examples of medicating animals for illness treatment will be obvious, and may span a wide variety of illnesses.
  • One example of medicating an animal for illness prevention is a proactive vaccination; another example is to proactively administer an antibiotic.
  • animals may be proactively medicated before they are introduced into another group of livestock, for example to guard against introducing an illness that they may carry or simply to ensure that ail animals in the group have received an identical medication regimen.
  • Medication might also be administered in anticipation of, or in response to, a change in weather conditions or a change in geographical location for an animal (such as moving from one climate to another).
  • animal medications are discussed without differentiation of the purpose for such medication.
  • Medication may be found in various forms, including solid and fluid. Solid substances may be ingestib!e, for example, while fluids may be injectable or may be administered orally or nasally. Embodiments of the present invention are directed toward improved apparatus for use with medication in fluid form, and the scope of the present invention also includes ethod(s) for using such apparatus
  • Medications provided in fluid form may vary widely in their viscosity, depending upon their chemical formulation. Viscosity is sometimes defined as the resistance of a substance to flow. The viscosity of water is relatively low, for example, while the viscosity of honey is relatively high. The viscosity of some substances can be changed by applying heat; for example, melting butter increases its ability to flow. Some fluid medications may have a viscosity that is relatively low and is similar to that of water, for example, and thus will flow quite easily. Other fluid medications are known that have a viscosity that is markedly different from water.
  • Fluid medications intended for use with animals are commonly marketed in multi-dose packaging, such as bottles that hold enough fluid for administering several doses
  • a bottle of medication might hold 500 milliliters, for example
  • the bottle might be made of glass or plastic, and a container having a configuration other than a bottle might be used.
  • the term“bottle” is used for ease of reference, and by way of illustration and not of limitation, as a container type in which medication may be contained.
  • One reason for marketing animal medication in multi-dose bottles is economic. The cost of the medication may be reduced, for example, by selling a larger quantify container and thereby reducing the relative cost of the packaging. Another reason for marketing animal medication in multi-dose bottles is that the dosage of many (if not ail) medications is prescribed with regard to the animal’s body weight. Accordingly, the correct amount of medication to use on a particular animal can be calculated and then withdrawn from the multi-dose bottle, after which it may be injected into the animal, and the remaining medication is then available for subsequent use.
  • a multi-dose bottle of fluid medication is typically marketed with a rubber membrane covering at least a portion of an opening at the top of the bottle.
  • the fluid medication is withdrawn from such bottle by placing a needle onto the tip of a syringe, inserting a tip of the needle into the rubber membrane, and withdrawing a plunger of the syringe until an appropriate amount of fluid is pulled into the syringe body (referred to herein as the syringe“barrel”); this same needle is then used for injecting the medication from the syringe into the animal.
  • FIG. 1 shows an example of a prior art syringe 100, and illustrates how the hollow barrel 130 of syringe 100 is commonly marked with fill lines 1 10 that are provided for measuring the amount of fluid contained therein.
  • a needle is placed over (or inside) the tip 140, and fluid enters through an opening or eye of the needle and into the syringe barrel 130.
  • the syringe includes a retractable plunger, a terminal end of which is shown at 120. (As will be obvious, as fluid medication is withdrawn from the bottle into the barrel 130, the plunger 120 movably extends outward from the proximal end of the syringe 100, although this is not illustrated in FIG. 1.)
  • a syringe as illustrated in FIG. 1 is constructed of plastic, making it relatively cheap to purchase.
  • a tab-shaped member 150 is also provided on syringe 100.
  • a person’s index finger is placed on the tab-shaped member 150 at one side of barrel 130 and the person’s middle finger is placed on the tab-shaped member 150 at the opposing side of barrel 130, and the person's thumb is then used to depress the terminal end of plunger 120 into the barrel in order to expel the medication from the barrel.
  • FIG. 2 As an alternative to the syringe 100 of FIG. 1 , an example of a so-called “pistol-grip” syringe is illustrated in FIG. 2. Fluid medication is drawn into a syringe of this type by pulling plunger 220 outwardly from the barrel 230. A tab-shaped member is not provided on a syringe of this type, as compressing or squeezing the handles 210 serves to expel medication from the barrel of a syringe having a pistol-grip configuration.
  • FIG. 3 illustrates yet another prior art syringe 300, and is referred to herein as a “tab-handled” syringe in this configuration
  • the syringe has a tabbed member 350 near the proximal end of barrel 330, and includes a handle-style tabbed member 320 affixed to the terminal end of the plunger.
  • the tabbed member 350 is used in a similar manner to tab-shaped member 150 of FIG. 1 , whereby a person places fingers on the tabbed member 350 on opposing sides of barrel 330; the person then presses down on tabbed member 320 using the person’s palm to depress the terminal end of the plunger into the barrel in order to expel the medication from the barrel.
  • the tabbed members 320, 350 of FIG. 3 typically provide improved comfort for the person using the tab-handled syringe.
  • the tips 240, 340 may be generally on the order of 3/8 to 7/16 inch in diameter and generally of similar height (and similarly, tip 140), and are generally constructed of metal. An interior area of this tip is intended for securabiy attaching a needle and is generally threaded for at least a portion thereof. A height of this threaded area is generally on the order of 1/8 inch to 1/4 inch. While not illustrated in detail on tips 240, 340 of FIGs. 2 and 3, the syringe tip also typically includes a protrusion that is centered within the exterior wall of the tip and that provides the opening through which a substance enters into the syringe barrel. (Notably, tips 140, 240, 340 are not designed for inserting through the rubber membrane of a medicine bottle.)
  • Syringes 200, 300 are often constructed, at least in part, of metal.
  • Glass or plastic might be used for the syringe barrel
  • a metal commonly used for syringes is stainless steel; another example is aluminum.
  • FIG. 4 illustrates an example of a prior art needle 400, which may be affixed to the distal end of syringes 100, 200, or 300. Needles are typically sold in standardized sizes, and thus the distal syringe ends 140, 240, 340 typically conform to the standard size of the proximal end of a needle.
  • FIGs. 4A and 4B illustrate bottom views showing examples of how a proximal end of needle 400 may be configured for securab!e attachment to the distal end of a syringe that has an internal threaded portion.
  • an approach 410 as shown in FIG.
  • a flanged area 420 extends radially outward from the proximal end of the needle (as is generally illustrated in FIG. 4).
  • Reference number 440 depicts the opening in the tip of the needle, and reference number 430 generally depicts the sidewall of needle 400.
  • a flanged area 480 extends perpendicularly outward from the proximal end of the needle, but in this configuration, is fashioned as having side edges that are not generally round.
  • Reference number 480 depicts the opening in the tip of the needle, and reference number 470 generally depicts the sidewall of needle 400.
  • a flanged area 420, 460 on the proximal end of a needle is designed to securabiy attach to a corresponding receiving area on the distal end of a syringe.
  • the securable attachment of a needle to a syringe tip relies on friction instead of an exterior flanged area, whereby the proximal end of needle 400 is placed over an exterior of the distal end (e.g., tip 140 of FIG. 1) of a syringe.
  • These approaches are commonly referred to as a Luer-style lock approach and a Luer-style slip approach, respectively, as is discussed in further detail below.
  • flanged area 420 is configured to extend perpendicularly outward as illustrated in FIG. 4A, it is preferably intended for use in a Luer-type slip connection rather than a Luer-type lock connection, due to the so-called“double start” or double helix configuration that is described for the internal threads of a Luer-type lock hub according to International Standard ISO 594-2: 1998(E), which is discussed in further detail below.
  • tabs may be added to the outer edge of flanged area 420, where these tabs are configured for engaging the internal threads of the
  • the sharp tip at the distal end of the needle 400 is inserted through the rubber membrane of the bottle.
  • the sharp tip of that same needle is inserted into an animal’s body, and the person holds tab-shaped member 150 while simultaneously depressing plunger 120 of syringe 100, squeezes the handles 210 of pistol-grip syringe 200, or holds tabbed member 350 while simultaneously depressing handle-style tabbed member 320 of tab-handled syringe 300.
  • the higher viscosity of the medication makes the injection process more time-consuming and physically more difficult for the person tasked with medicating the animal.
  • the general configuration of a plastic syringe as illustrated in FIG. 1 does not enable a person using the syringe to have sufficient leverage when attempting to inject the medication into an animal.
  • Tab-shaped member 150 is known to collapse or break in some instances, due to the physical force that must be exerted while depressing plunger 120.
  • the plunger shaft is also known to break in some instances, for example due to misalignment as it moves within the barrel or due to age-related brittleness.
  • the syringes 200, 300 of FIGs. 2 - 3 are better adapted for withstanding the physical force required for expelling a higher-viscosity medication from the syringe barrel and for allowing the person using the syringe to have better leverage during the injection process. (Because the leverage is improved, the time required to complete the injection may be shortened as compared to use of a plastic syringe configured as shown at 100 of FIG. 1 , which benefits the person and the animal.)
  • preferred embodiments of the present invention are directed toward improved syringeability of medications having a relatively high viscosity.
  • the disclosed syringe adapter may function suitably with lower-viscosity medications as well, and is therefore not deemed to be limited to use with particular medications.
  • a preferred embodiment of the present invention provides a new tip that operates as a syringe adapter for withdrawing medication from a bottle.
  • This tip is preferably affixed to a pistol-grip syringe of the type illustrated in FIG. 2 or a tab-handled syringe of the type illustrated in FIG. 3.
  • the pistol-grip or tab-handled syringe may be formed from plastic, metal, or other substance(s), as noted earlier. Accordingly, use of an embodiment of the present invention addresses the issue of drawing a higher-viscosity fluid from a bottle as well as the issue of providing sufficient leverage for subsequent injection.
  • the larger opening of the disclosed syringe adapter addresses syringeability issues by improving draw time of higher-viscosity medications and, when this adapter is affixed to a pistol-grip or tab-handled syringe, the medication withdrawn into the pistol-grip or tab-handled syringe can be more easily administered from the syringe barrel (noting that, in some embodiments, the syringe adapter will be replaced with a needle prior to injecting the medication).
  • FIG. 5 illustrates one embodiment of the syringe adapter disclosed herein.
  • the syringe adapter has a sidewall extending between a proximal end and a distal end, and the interior surface of the sidewall defines a chamber through which fluid medication flows.
  • the shape of the syringe adapter 500 is generally conical in an upper portion and generally cylindrical in a lower portion. While not illustrated in FIG. 5, an interior of at least a portion of the lower portion is preferably tapered, with a 6 percent taper extending from the proximal end toward the distal end. This tapered shape conforms the interior surface to international Standard ISO 594-2: 1998(E) and its replacement ISO 80369-7:2016, which are directed toward conical fittings for health-care applications.
  • the overall length of the syringe adapter is not shorter than 3/8 to 1/2 inch, by way of illustration but not of limitation, as this length will enable the syringe adapter to sufficiently extend into a bottle of medication to be withdrawn.
  • An upper range of the overall length conversely, may be on the order of 1 to 2 inches, by way of illustration but not of limitation.
  • a preferred diameter of the hole in the distal end of the tip of the syringe adapter is on the order of 0.10 inches, although embodiments are not limited to this diameter.
  • Thickness of the sidewall of the syringe adapter is preferably on the order of 0.050 inches, although embodiments are not limited to this thickness. Using a sidewall thickness of 0.050 inches and an opening of 0.10 inches results in a syringe adapter having an overall diameter of 0.20 inches at the end to be inserted into the bottle of medication, in this example configuration.
  • the proximal end of the disclosed syringe adapter attaches to a syringe using a Luer-type lock or a Luer-type slip.
  • Luer-type locks and Luer-type slips are known approaches for making leak-free connections on fluid fittings, and are described in the above-cited International Standards
  • a Luer-type lock provides a threaded attachment, whereby two pieces of a configuration are held together by rotating a flanged area (such as flanged area 420 of FIG. 4A when augmented with tabs or flanged area 460 of FIG.
  • the syringe adapter 500 as illustrated in FIG. 5 has an external flanged area 510 on the proximal end (shown without tabs extending from the outer edge, for drafting convenience), and a two-part connection is made by inserting this flanged end into corresponding internal threads on a distal end of a syringe (as discussed above with reference to the syringe tips illustrated at 240, 340).
  • a conventional height for this internal threaded portion of a pistol-grip or tab-handled syringe tip is approximately 1/8 inch in length, and accordingly, a flanged area 510 on the proximal end of syringe adapter 500 is preferably on the order of 1/16 to 1/8 inch in height.
  • the shape of flanged area 510 may correspond generally to flanged area 420 or 460 (for example, by extending perpendicularly and radially from the proximal end of the syringe adapter, although a strictly circular shape is not required), although another shape providing for a securab!e attachment may be used without deviating from the scope of the present invention.
  • the proximal end of the syringe adapter 500 may omit the flanged area shown at 510 and is attached and held to the distal end of the syringe by friction in a Luer-type slip approach.
  • FIG. 6 illustrates another embodiment of the syringe adapter disclosed herein in this embodiment, syringe adapter 600 includes a radial extension feature 610, which is preferably configured as extending perpendicularly and radially outward from the body of the syringe adapter and is shown in FIG. 6 as being located relatively near to the proximal end of syringe adapter 600.
  • a radial extension feature 610 is preferably configured as extending perpendicularly and radially outward from the body of the syringe adapter and is shown in FIG. 6 as being located relatively near to the proximal end of syringe adapter 600.
  • radial extension feature 610 may be placed at another location on the syringe adapter, for example being located closer to the conical portion thereof.)
  • the radial extension feature 610 also serves to prevent inserting the syringe into the medication bottle far enough that the attachment point (e.g., Luer-type slip or lock) between the syringe and the syringe adapter would come into contact with the medication.
  • a diameter of radial extension feature 610 is sufficiently large as to exceed the diameter of a conventional rubber membrane on a medicine bottle.
  • the diameter of radial extension feature 610 may be, by way of example, on the order of twice the diameter of the cylindrical portion of syringe adapter 600. (Syringe adapter 600 may omit the flanged area 620 when relying on a Luer-type slip attachment, and is depicted without tabs extending from the outer edge for drafting convenience, as was discussed above with reference to flanged area 510.)
  • a preferred material for the disclosed syringe adapter is plastic, which will allow it to be economically produced as a disposable item, although another material may be used without deviating from the scope of the present invention.
  • the syringe adapter or portion(s) thereof may be constructed from stainless steel, aluminum, or another metal (or combinations thereof), noting that metal generally provides increased strength and durability as compared to plastic.
  • the disclosed syringe adapter does not need to come into physical contact with a particular animal (i.e., because the physical contact occurs at the needle used to inject the medication), and thus re-use of the syringe adapter for medicating multiple animals need not introduce cross-contamination concerns.
  • FIGs. 5 and 6 illustrate a syringe adapter shape that is generally conical in an upper portion and generally cylindrical in a lower portion, this is by way of illustration and not of limitation.
  • an outer shape of the syringe adapter may be generally cylindrical while preferably having a tapered interior shape for at least a portion of the proximal end, noting that such interior taper enables the syringe adapter to comply with the above-cited International Standards
  • an outer shape of the syringe adapter may be generally conical in an upper portion and generally cylindrical in a lower portion, and in this alternative, the relative length of the upper and lower portions varies from the embodiments illustrated in FIGs. 5 and 8 (and again, at least a portion of such configuration preferably has a tapered interior shape at the proximal end, as shown by the dotted lines, to thereby conform to the above-cited International Standards).
  • the exterior taper of the upper portion as illustrated in FIGs. 5 - 8 and 8 may tend to provide a better seal, and thus be less likely to leak, during such time as the syringe adapter is inserted through the rubber membrane of a bottle.
  • a radial extension member such as that shown at reference number 810 of FIG. 6 may be added to these configurations if desired.
  • FIG. 9 illustrates yet another embodiment of the disclosed syringe adapter in this embodiment, syringe adapter 900 includes a radial extension feature 910, similar to the previously-discussed radial extension feature 610 of FIG. 8.
  • FIG. 9 depicts radial extension feature 910 as being located approximately midway along the length of the syringe adapter, by way of illustration but not of limitation.
  • the radial extension feature illustrated at 810 of FIG. 8 is illustrated as having a disk-like shape with generally flat upper and lower surfaces
  • FIG. 9 illustrates an alternative shape where an upper surface of the radial extension feature 910 has a somewhat domed or tapered shape.
  • This tapered or domed portion is shown at reference number 920 and sits atop a disk-like portion 930.
  • the lower surface of the radial extension feature may taper in addition to, or instead of, the upper surface thereof, although this has not been illustrated. (Note that the particular shape and dimensions of portions 920, 930 may vary, and thus FIG. 9 provides one example by way of illustration but not of limitation.)
  • FIG. 9 also illustrates the upper portion 940 of the syringe adapter 900 as having a generally conical shape which is somewhat less tapered than the upper portion as illustrated for the syringe adapters 500, 800 of FIGs. 5 and 8, and having a generally cylindrical shape for the lower portion 950.
  • a length of the conical portion 940 may be .32 inches; a length of the cylindrical portion 950 may be .48 inches; a height or thickness of portion 930 may be 07 inches; a diameter of radial extension feature 910 may be .75 inches; a diameter of the distal and proximal ends of conical portion 940 may be .156 inches and .174 inches, respectively; and a diameter of cylindrical portion 950 may be .24 inches.
  • FIG. 10 illustrates placement of a syringe adapter on a syringe.
  • the syringe in FIG. 10 corresponds to the tab-handled syringe 300 of FIG. 3 and the syringe adapter corresponds to the embodiment shown at 900 of FIG. 9.
  • Syringe tip 340’ provides a point of attachment for the syringe adapter 900, and syringe tip 340’ is shown as being generally cylindrical; as contrasted with syringe tip 340 as earlier illustrated, syringe tip 340’ is shown with a ribbed exterior mid-section 345 that may provide for a person to securely grip the syringe tip 340’ while the syringe adapter 900 is being inserted therein (or removed therefrom).
  • the connection between syringe tip 340’ and syringe adapter 900 is preferably a Luer-type lock, but a Luer-type slip may be used alternatively without deviating from the scope of the present invention (it will be understood that in FIG. 10, a portion of the proximal end of syringe adapter 900 is located inside the distal end of tip 340’, following the connection.)
  • FIG. 11 illustrates one example of placement of a needle on a syringe adapter, for an embodiment in which the syringe adapter remains in place while medication is administered through an attached needle.
  • the syringe adapter in FIG. 1 1 corresponds to the embodiment shown at 900 of FIG. 9, the attachment between the syringe and syringe adapter 900 corresponds to the attachment illustrated in FIG. 10, and the needle corresponds to the needle 400 of FIG. 4.
  • needle 400 is shown as having its proximal end placed over the distal end of the syringe adapter.
  • needle 400 Includes a small flanged area 420 that enables it to securably attach to the interior of a Luer-type lock, although the illustrated attachment in FIG. 11 is a Luer-type slip connection. Accordingly, the needle 400 may be attached to, and removed from, the syringe adapter with relative ease (e.g., by pushing the proximal end of the needle onto the distal end of the syringe adapter and pulling it therefrom, respectively).
  • flanged area 420 is shown as directly abutting the portion of the syringe adapter shown as having a domed shape, this is by way of illustration: alternatively, there may be a gap beneath flanged area 420.
  • FIG. 12 illustrates still another embodiment of the disclosed syringe adapter, and its placement on a syringe.
  • syringe adapter 1200 includes a radial extension feature 1210 with a tapered or domed upper surface, similar to the previously-discussed radial extension feature 910 of FIG. 9.
  • the conical portion of the syringe adapter 1200 is somewhat longer (and it should be noted that embodiments of the present invention are not limited to a specific dimension, as has been discussed).
  • FIG. 12 also illustrates a Luer-type connecting member 1220 affixed to the proximal end of syringe adapter 1200 (where 2 horizontally-oriented“ribs” are illustrated on the surface of member 1220, by way of illustration but not of limitation).
  • This connecting member 1220 is shown in FIG. 12 as connecting syringe adapter 1200 to a syringe, which may be syringe 300 of FIG. 3 (by way of illustration but not of limitation).
  • the point of connection on syringe 300 is shown in FIG. 12 as comprising a syringe tip 340', similar to that which was discussed above with reference to FIG.
  • connecting member 1220 of syringe adapter 1200 is removably inserted into which connecting member 1220 of syringe adapter 1200 is removably inserted.
  • connecting member 1220 is made from metal while remaining portions of syringe adapter 1200 are made from plastic, and a bond is made between the metal and plastic during manufacturing.
  • connecting member 1220 attaches to syringe tip 340’ with a Luer-type lock connection (rather than a Luer-type slip connection).
  • connecting member 1220 preferably includes a flanged area at its proximal end (such as flanged area 460 of FIG.
  • Luer-type lock connection is made by inserting connecting member 1220 into syringe tip 340’ and then twisting the syringe adapter 1200 until the flanged area locks into place in the internal threaded portion of the syringe tip 340’.
  • This type of connection is deemed beneficial for providing a more secure attachment between the syringe and the syringe adapter.
  • FIG. 13 illustrates yet another embodiment of the disclosed syringe adapter and its placement on a syringe.
  • syringe adapter 1300 differs from syringe adapter 1200 of FIG. 12 in that a Luer-type connecting member 1320 affixed to the proximal end of syringe adapter 1300 uses a different Luer-type connecting member 1320 affixed to the proximal end of syringe adapter 1300 uses a different
  • connecting member 1320 has a multi-sided exterior shape, shown by way of illustration as being hexagonal in at least a portion thereof. More particularly, in the example shown in FIG. 13, connecting member 1320 has a hexagonal upper portion 1322 and a cylindrical lower portion 1321.
  • connecting member 1320 is made from metal while remaining portions of syringe adapter 1300 are made from plastic, and a bond is made between the metal and plastic during manufacturing.
  • connecting member 1320 attaches to syringe tip 340 ! with a Luer-type lock connection (rather than a Luer-type slip connection). While not shown in FIG.
  • connecting member 1320 preferably includes a flanged area at its proximal end (such as flanged area 460 of FIG. 4B), and the Luer-type lock connection is made by inserting connecting member 1320 into syringe tip 340’ and then twisting the syringe adapter 1300 until the flanged area locks into place in the internal threaded portion of the syringe tip 340’.
  • the Luer-type lock connection is deemed beneficial for providing a more secure attachment between the syringe and the syringe adapter.
  • FIG. 14 illustrates a further embodiment of the disclosed syringe adapter, showing an exterior view' as well as cross-sectional views of placement thereof upon a syringe and as exploded.
  • the syringe in FIG. 14 corresponds to the tab-handled syringe 300 of FIG. 3 with its syringe tip 340.
  • Syringe adapter 1400 in this embodiment, includes a radial extension member 1410 and the proximal end as denoted by reference number 1420 includes a Luer-type connecting member, where connecting member 1420 in turn includes a flanged area 1421 at its proximal end (such as flanged area 460 of FIG.
  • syringe adapter 1400 for removably attaching syringe adapter 1400 to the distal end of syringe 300.
  • the Luer-type lock connection is made by inserting connecting member 1420 into syringe tip 340 and then twisting the syringe adapter 1400 until the flanged area 1421 locks into place in the internal threaded portion of the syringe tip 340 (as illustrated in the non-expioded cross-sectional view) to thereby provide a secure attachment between the syringe and the syringe adapter.
  • the syringe adapter is affixed to a syringe (which, as noted earlier, is preferably a pistol-grip or tab-handled syringe); the syringe adapter is inserted into a bottle of medication; the plunger of the syringe is pulled back to withdraw the desired dosage of medication from the bottle into the syringe barrel; the syringe adapter is removed from the bottle, while the plunger remains stationary; the syringe adapter is replaced with a needle; and the medication (or some portion thereof) is then injected by pushing the plunger forward (for example, by squeezing the pistol-grip handies or pressing down on the tabbed handle) to expel medication from the syringe barrel if it is desired to reuse the syringe adapter, then the needle is removed from the syringe, after which the above process
  • the syringe adapter operates, in some other embodiments, as follows: the syringe adapter is affixed to a syringe (preferably a pistol-grip or tab-handled syringe); the syringe adapter is inserted into a bottle of medication; the plunger of the syringe is pulled back to withdraw the desired dosage of medication from the bottle into the syringe barrel; the syringe adapter (which remains attached to the syringe) is removed from the bottle, while the plunger remains stationary; a needle is affixed to the syringe adapter (and note that the syringe adapter remains affixed to the syringe); and the medication (or some portion thereof) is then injected by pushing the plunger forward (for example, by squeezing the pistol-grip handies or pressing down on the tabbed handle) to expel medication from the syringe barrel.
  • a syringe preferably
  • While medications have been discussed herein as commonly being sold in a multi-dose bottle, this is by way of illustration and not of limitation.
  • the disclosed syringe adapter may be used beneficially for medication that is sold in a single-use dosage. Also, it should be noted that while some discussions herein refer to expelling “the withdrawn medication” or“emptying” the syringe, this is by way of illustration and not of limitation: the scope of the present invention does not require withdrawn medication to be expelled in full nor does it require a syringe to be fully emptied.
  • the disclosed syringe adapter may be included with purchase (e.g., within the packaging) of a higher-viscosity medication.
  • a multi-pack of the disclosed syringe adapter may be included with such purchase, particularly when the medication is sold in a multi-dose bottle.
  • the disclosed syringe adapter may also be sold separately from medication.
  • Examples of higher-viscosity animal medications with which the disclosed syringe adapter may be used beneficially include Nufior ® , Nuflor Gold ® , and Resflor Gold ® .
  • Nuflor”,“Nuflor Gold”, and“Resflor Gold” are registered trademarks of intervet Inc. in the United States, other countries, or both intervet is now known as “Merck Animal Health”.
  • These medications are commonly sold in 500-milliliter multi-dose bottles and may be administered, by way of example, in dosages of 36 to 60 milliliters per animal. Accordingly, a single multi-dose bottle may be used to treat generally 8 to 14 animals at this dosage range.
  • Viscosity of a substance may vary with temperature. Viscosity is commonly measured in units termed“centipoise”, which may be abbreviated as“cP” or“cps”. Water, at 70 degrees Fahrenheit, has a viscosity of approximately 1 cps, and by way of comparison, blood generally has a viscosity of about 10 cps. By convention, a temperature of 70 degrees Fahrenheit is used as a reference point for measuring cps, and thus when a temperature is not mentioned for a particular cps measurement, it should be assumed that the temperature associated with the stated measurement is 70 degrees Fahrenheit.
  • An embodiment of the present invention is believed to be advantageous for fluid medications having a viscosity of at least 50 to 100 cps at a temperature of at least 5 degrees Celsius, as well as for fluid medications having a higher cps at this temperature (noting, as stated above, that viscosity varies with temperature).
  • FIG. 15 presents tables containing measurements from tests conducted to compare use of a sample version of the disclosed syringe adapter to use of conventional needles.
  • the tested medication was Resf!or Gold ® , and a withdrawn quantify thereof was 30 cc (computed as a desired volume for treating an animal with a body weight of 500 pounds). Results of these tests will now be discussed
  • a 16-gauge needle has a larger tip opening than an 18-gauge needle, and will therefore withdraw a solution faster than the 18-gauge, although the 16-gauge needle is thought to be disfavored for at least some situations because it may allow the (relatively expensive) medication to leak out during the medicating process.
  • a 16-gauge needle is thought to be too large to use on smaller animals.
  • the diameter of the opening in the distal end of the syringe adapter was approximately 0.094 inches.
  • an embodiment of the present invention improves syringeability of higher-viscosity medications, allowing such medication to be withdrawn from a bottle in much less time as compared to the known approach of withdrawal using a needle. More animals may therefore be medicated in a given period of time, leading to improved productivity of persons caring for the animals as well as enabling overall improved health for the animals. No longer will higher viscosity be a barrier to the market, and because medication of this type will be more readily administered when using a syringe adapter as disclosed herein, improvement may be expected in animal health, and market share and/or market presence for the medication may improve as well.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un appareil amélioré destiné à être utilisé avec un médicament sous forme fluide, qui est particulièrement avantageux pour des médicaments ayant une viscosité relativement élevée. L'adaptateur de seringue de l'invention a une ouverture qui est relativement grande, par rapport à une aiguille classique et, par conséquent, la fixation de l'adaptateur de seringue de l'invention à une seringue améliore l'injectabilité de médicaments à viscosité plus élevée. Lorsque l'adaptateur de seringue de l'invention est fixé à une seringue à poignée pistolet ou à poignée de type languette, le médicament retiré dans la seringue à poignée pistolet peut être administré plus facilement depuis le cylindre de seringue. Dans certains modes de réalisation, l'adaptateur de seringue sera remplacé par une aiguille avant l'injection du médicament tandis que, dans certains autres modes de réalisation, l'aiguille est fixée à l'adaptateur de seringue en place pour l'injection.
PCT/US2019/056282 2018-10-21 2019-10-15 Adaptateur de seringue pour médicament WO2020086332A1 (fr)

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US16/166,111 US11097058B2 (en) 2018-06-15 2018-10-21 Syringe adapter for medication

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4008297A1 (fr) * 2020-12-03 2022-06-08 Beaver-Visitec International (US), Inc. Poignée pour fixer un cystotome sur une seringue, ensemble associé et procédé associé

Citations (7)

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Publication number Priority date Publication date Assignee Title
US5195985A (en) * 1990-05-25 1993-03-23 Hall John E Syringe having a retractable needle
US5733258A (en) * 1995-09-22 1998-03-31 Lane; Donovan R. Livestock biological and vaccine handling system to include pistol grip syringe and cartridge
US6117113A (en) * 1988-12-14 2000-09-12 Inviro Medical Devices Ltd. Safety syringe needle device with interchangeable and retractable needle platform
US20080188816A1 (en) * 2006-11-15 2008-08-07 Arte Corporation Luer-lock type cykindrical tip of syringe
US20080287884A1 (en) * 2007-04-17 2008-11-20 Warden Matthew P Convertible syringe system
US20110028909A1 (en) * 2009-07-30 2011-02-03 Becton, Dickinson And Company Medical Device Assembly
WO2012023955A1 (fr) * 2010-08-20 2012-02-23 Dr. Reddy's Laboratories, Ltd. Dépôt phospholipidique

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6117113A (en) * 1988-12-14 2000-09-12 Inviro Medical Devices Ltd. Safety syringe needle device with interchangeable and retractable needle platform
US5195985A (en) * 1990-05-25 1993-03-23 Hall John E Syringe having a retractable needle
US5733258A (en) * 1995-09-22 1998-03-31 Lane; Donovan R. Livestock biological and vaccine handling system to include pistol grip syringe and cartridge
US20080188816A1 (en) * 2006-11-15 2008-08-07 Arte Corporation Luer-lock type cykindrical tip of syringe
US20080287884A1 (en) * 2007-04-17 2008-11-20 Warden Matthew P Convertible syringe system
US20110028909A1 (en) * 2009-07-30 2011-02-03 Becton, Dickinson And Company Medical Device Assembly
WO2012023955A1 (fr) * 2010-08-20 2012-02-23 Dr. Reddy's Laboratories, Ltd. Dépôt phospholipidique

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4008297A1 (fr) * 2020-12-03 2022-06-08 Beaver-Visitec International (US), Inc. Poignée pour fixer un cystotome sur une seringue, ensemble associé et procédé associé

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