WO2020086038A3 - Topical compositions comprising tolperisone and selective cox-2 inhibitor combination - Google Patents

Topical compositions comprising tolperisone and selective cox-2 inhibitor combination Download PDF

Info

Publication number
WO2020086038A3
WO2020086038A3 PCT/TR2019/050834 TR2019050834W WO2020086038A3 WO 2020086038 A3 WO2020086038 A3 WO 2020086038A3 TR 2019050834 W TR2019050834 W TR 2019050834W WO 2020086038 A3 WO2020086038 A3 WO 2020086038A3
Authority
WO
WIPO (PCT)
Prior art keywords
tolperisone
selective cox
topical compositions
inhibitor combination
pharmaceutically acceptable
Prior art date
Application number
PCT/TR2019/050834
Other languages
French (fr)
Other versions
WO2020086038A2 (en
Inventor
Emine TUNCAY
Melda MISIRLI
Seyhan TURKKAN
Nur PEHLIVAN AKALIN
Ali Turkyilmaz
Original Assignee
Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi filed Critical Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi
Publication of WO2020086038A2 publication Critical patent/WO2020086038A2/en
Publication of WO2020086038A3 publication Critical patent/WO2020086038A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to topical pharmaceutical compositions comprising tolperisone or a pharmaceutically acceptable salt, solvate, polymorph, isomer, enantiomer or rasemic mixture thereof and a selective COX-2 inhibitor or pharmaceutically acceptable salts, solvates, polymorphs, isomers, enantiomers or rasemic mixtures thereof.
PCT/TR2019/050834 2018-10-26 2019-10-07 Topical compositions comprising tolperisone and selective cox-2 inhibitor combination WO2020086038A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR201816049 2018-10-26
TR2018/16049 2018-10-26

Publications (2)

Publication Number Publication Date
WO2020086038A2 WO2020086038A2 (en) 2020-04-30
WO2020086038A3 true WO2020086038A3 (en) 2020-06-25

Family

ID=70332024

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/TR2019/050834 WO2020086038A2 (en) 2018-10-26 2019-10-07 Topical compositions comprising tolperisone and selective cox-2 inhibitor combination

Country Status (1)

Country Link
WO (1) WO2020086038A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1362585A2 (en) * 2001-01-26 2003-11-19 Osmotica Corp. Pharmaceutical compositions containing a cox-ii inhibitor and a muscle relaxant
EP2514409A1 (en) * 2011-04-19 2012-10-24 Sanovel Ilaç Sanayi Ve Ticaret Anonim Sirketi Topical pharmaceutical compositions of nimesulide and methylsulfonylmethane

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1362585A2 (en) * 2001-01-26 2003-11-19 Osmotica Corp. Pharmaceutical compositions containing a cox-ii inhibitor and a muscle relaxant
EP2514409A1 (en) * 2011-04-19 2012-10-24 Sanovel Ilaç Sanayi Ve Ticaret Anonim Sirketi Topical pharmaceutical compositions of nimesulide and methylsulfonylmethane

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CATANZARO, JOSEPH M. ET AL.: "Propylene glycol dermatitis", JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, vol. 24, no. 1, 1991, pages 90 - 95, XP023851686 *

Also Published As

Publication number Publication date
WO2020086038A2 (en) 2020-04-30

Similar Documents

Publication Publication Date Title
WO2017019804A3 (en) Compounds and methods for kinase modulation, and indications therefor
WO2016012965A3 (en) Substituted phenyl alkanoic acid compounds as gpr120 agonists and uses thereof
MA47970B1 (en) Imidazo-piperidine fused jak inhibitor compound
WO2008005368A3 (en) Piperazines as p2x7 antagonists
PH12020500446A1 (en) Bisamide sarcomere activating compounds and uses thereof
MX2018003284A (en) Antifungal compounds and processes for making.
EP4201399A3 (en) Compositions and methods of use of 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl) methyl) -2,2-difluoroacetamide
MX2022005615A (en) Tricyclic dihydroimidazopyrimidone derivative, preparation method therefor, pharmaceutical composition and use thereof.
WO2019178191A8 (en) O-glycoprotein-2-acetamido-2-deoxy-3-d-glycopyranosidase inhibitors
WO2008096001A8 (en) Hcv inhibiting macrocyclic phenylcarbamates
WO2016205738A3 (en) Delivery systems for controlled drug release
EP4041733A4 (en) Novel derivatives having 2,3-dihydro-1h-indene or 2,3-dihydrobenzofuran moiety or pharmaceutically acceptable salt thereof and pharmaceutical compositions comprising the same
NZ721645A (en) Compounds for use as gpr120 agonists
MX2020008498A (en) Derivatives of sobetirome.
WO2016159576A3 (en) 1,2-naphthoquinone derivative and method for preparing same
MX2023007447A (en) Aromatic heterocyclic compound, and pharmaceutical composition and application thereof.
PH12019550154A1 (en) Azetidine derivative
MX2021007800A (en) Compositions and methods of use of 2-(4-chlorophenyl)-n-((2-(2,6- dioxopiperidin-3-yl)-1-oxoisoindolin-5yl) methyl)-2,2-difluoroace tamide.
EP3946288A4 (en) Substituted 5-cyclopropyl-1h-pyrazol-3-yl-amine derivatives as selective cdk12/13 inhibitors
WO2019203751A3 (en) Tolperisone and selective cox-2 inhibitor combinations
MX2022006104A (en) Oral pharmaceutical composition comprising carbamate compound and preparation method therefor.
WO2015191681A3 (en) Substituted pyridinones as mgat2 inhibitors
WO2020086038A3 (en) Topical compositions comprising tolperisone and selective cox-2 inhibitor combination
WO2016006974A3 (en) Novel triazolopyrimidinone or triazolopyridinone derivatives, and use thereof
EP3851438A4 (en) Btk inhibitor, pharmaceutically acceptable salt, polymorph and application thereof

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 19875183

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 19875183

Country of ref document: EP

Kind code of ref document: A2