WO2020085935A1

WO2020085935A1 - Method for the automated restoration of brain functions

Info

Publication number: WO2020085935A1
Application number: PCT/RU2018/000702
Authority: WO
Inventors: Игорь Игоревич ДОЛГУШИН
Original assignee: Общество С Ограниченнной Ответственностью "Май Брэйн"
Priority date: 2018-10-24
Filing date: 2018-10-24
Publication date: 2020-04-30

Abstract

The invention relates to a combined therapeutic and prophylactic product incorporating both a set of exercises and a molecular complex for stimulating cognitive brain functions. A method for restoring brain functions using a computer device includes obtaining a first set of data about a user; processing user data at least on the basis of the first set of user data obtained; evaluating the baseline cognitive abilities of the user on the basis of the user data processed; determining on the basis of the user data processed a composition of a molecular complex and establishing a personalized programme of when the user is to take the molecular complex; determining a group of cognitive exercises on the basis of the user data and establishing a personalized programme of when the user is to perform the group of cognitive exercises determined; sending instructions to the user regarding when to take the selected molecular complex according to the personalized programme established; sending at least one cognitive exercise to the user; obtaining and evaluating the results of the user's performance of at least a portion of the cognitive exercises according to the personalized programme established; obtaining a second set of data about the user; processing the user data and evaluating the results of the brain function restoration conducted.

Description

METHOD FOR AUTOMATED RECOVERY

BRAIN FUNCTIONS

FIELD OF THE INVENTION

The invention relates to a comprehensive therapeutic and prophylactic product that combines a set of exercises and a molecular complex to stimulate cognitive functions of the brain.

State of the art

One of the most urgent tasks in society is to ensure effective cognitive activity, the prevention of neurodisstructive pathologies, improve the cognitive functions of the human brain, as well as radically increase the period of active, full, able-bodied human life while ensuring a corresponding reduction in the relative proportion of patients with severe dementia and neuropathology (Alzheimer's disease and so forth). Effective cognitive activity in turn depends on complex mental operations. It is well known that many factors influence the cognitive functions of the brain, in particular, age and lifestyle.

Currently, the period of rapid development is undergoing a new interdisciplinary scientific field, which is characterized as "educational neuroscience." In the framework of the direction, both early periods of brain development and its features in old age are considered. Regarding the latter case, it was found that neuroplasticity extends to the entire period of a person’s life. Therefore, educational technologies, such as cognitive training, are important not only in childhood and adolescence, but also for people of age. Pharmacological and non-pharmacological approaches are used to work with patients with mnestic-intellectual decline, and especially with mild cognitive decline syndrome. The latter involves the following steps:

1. Neuropsychological diagnosis of the cognitive sphere:

- assessment of the state of mental functions, a description of the structure of disorders in the etiological and nosological aspects;

- assessment of the state of mental functions in terms of potential positive and negative dynamics;

- assessment of the dynamics of the cognitive sphere during therapy.

2. Conducting corrective measures (cognitive training) of various disorders associated with mild cognitive decline syndrome, signs of increased mental aging, depression, dementia, etc.

3. Conducting cognitive training for different types of normal aging.

4. Work with relatives of patients with dementia of a diagnostic direction to identify early symptoms of mnestic-intellectual decline, as well as correctional - to improve the quality of life of relatives.

The need for cognitive training is based on studies confirming that high mental activity reduces the risk of dementia. Thus, it can provide a high neuroprotective potential.

Comprehensive treatment programs that show their effectiveness are developed within the framework of gerontology and geriatrics, implying that their target audience is patients with mild cognitive decline syndrome.

In domestic science, the basis of cognitive training is the concept of three structural and functional brain blocks of A.R. Luria, which allowed us to describe the structural and functional features of the cognitive sphere in normal and pathological aging, as well as the typology of aging. Within the framework of this concept, the following principles of training were developed:

1. The principle of qualification of a syndrome of disorders of higher mental functions. It involves a detailed syndromic neuropsychological analysis in combination, as well as a positive diagnosis of intact functions.

2. The principle of reliance on safe mental functions implies taking into account the forms of both verbal and non-verbal activity of the patient.

3. The principle of reliance on the subject activity of the patient.

4. The principle of taking into account the characteristics of the patient’s personality, mainly the structure of the cognitive sphere, the characteristics of the professional sphere and cognitive styles, emotional and personal.

5. The principle of control implies the timely correction of errors by a specialist in the process of activity and upon completion of tasks.

6. The principle of reliance on different levels of organization of mental functions. It implies arbitrariness in the patient’s activities in fulfilling tasks for hardened and automated activities.

7. The principle "from simple to complex" is logical in connection with the different capabilities of each patient.

8. The regularity of cognitive training (daily or 2-3 times a week). Only a similar approach can give effect.

It is believed that effective cognitive training should have focused on all three components of the mental sphere:

1) neurodynamic parameters of activity; 2) arbitrary regulation, control and programming of activities;

3) the operational components of mental activity (attention, memory, thinking, speech, gnosis, praxis, constructive activity).

The principle of regularity should be strictly observed. Classes lasting from 15-20 to 40-50 minutes (based on the patient's condition) are best done in the morning. More shortened first classes can be gradually extended. In order to avoid excessive load, it is necessary to combine tasks for the development of various functions. It is important to periodically return to difficult tasks for their successful implementation. Before each new task, it is advisable to discuss the sequence of its actions and operations.

For classes, it is necessary to select tasks that are performed at a different pace, with switching both within one activity and from one to another. Difficulties arising in the performance of tasks should be compensated by stimulation of speech regulation of activity. Also important is the control function, which should come not only from the side of the trainer, but also from the side of the patient, both at the moment and the whole activity.

Speaking about the structure of the lesson, it should be noted that it should begin with reflection, continue with training, then again reflection and the task of verification in the next lesson. Such tasks can update the memory of past events and impressions (orally or in writing to present the plot of a famous literary work, a story about life events, memories of famous historical events, etc.) and current events related to the fulfillment of tasks in the last lesson.

In the department of geriatric psychiatry, FSBI NCHPZ, relying on these principles of training by neuropsychologists, correction of the mnestic-intellectual decline in patients with mild cognitive decline syndrome and mild dementia of the Alzheimer's type. Tasks that are included in the classes are aimed at training:

- visual, auditory and tactile perception;

- voluntary and involuntary attention;

- kinesthetic, kinetic and spatial components of voluntary movements;

- optical-spatial and constructive activities;

- expressive and impressive speech, including written;

- accounts;

- visual, auditory and motor memory;

- verbal and non-verbal thinking.

As can be seen from this example, cognitive training can be used not only for the treatment of mild cognitive decline syndrome, but also for dementia. Also, the effectiveness of this method in combination with drug therapy has been identified in the treatment of post-stroke cognitive impairment. Moreover, he showed greater effectiveness compared exclusively with drug therapy.

Similar data are given in another study, where computer programs were used as cognitive stimulation.

They also indicate that such an approach is more effective than drug treatment in combination with a tonic neurorehabilitation effect (exercise therapy, massage, balance training) and spontaneous restoration of cognitive functions in the early recovery period of a stroke. At the same time, the indicated difference remains in the history of at least 6 months. The authors suggest that efficiency, good tolerance and the possibility of home use make computer programs promising in the rehabilitation process. It is noteworthy that for patients who have had a stroke, the prospect of using this method is much higher than those suffering from Alzheimer's disease due to a more significant neurodynamic defect in vascular pathology.

A special stage in conducting cognitive training is to evaluate its effectiveness. Since existing knowledge in this area is not enough, it is necessary to create effective tools for this.

The results of experimental studies indicate the possibility of achieving not only short-term, but also long-term effects using cognitive training programs of the corresponding functions. It is noteworthy that sometimes it is possible to transfer the positive effect to other cognitive functions similar to the trainees, but not identical to them. In addition, this approach can affect the physiological and structural changes in the brain.

The prior art includes various publications, including scientific articles and research. Various approaches are known for stimulating brain functions, in particular, cognitive training, which is a set of exercises aimed at developing logic, memory, and concentration (for example, Strauch В & Aging% The Secret Life of the Grown-Up Brain. - Viking, 2010 ) In addition, pharmaceutical and other drugs are widely known, for example, nootropic drugs that improve the intellectual activity of the brain.

One of the shortcomings of the existing methods is the inconsistency of taking pharmaceutical and other drugs with cognitive exercises. When prescribing a course of exercise, taking drugs does not take into account the individual mental and physiological characteristics of a particular user, which reduces the effectiveness of restoration of brain functions.

Another task is to automate the process of taking drugs and performing cognitive exercises, since the constant finding under the supervision of a doctor in the modern world for most users is difficult.

SUMMARY OF THE INVENTION

According to one aspect of the present technical solution, a method for an automated restoration of brain functions, implemented on a computer device, is proposed, which includes: - obtaining first user data including at least one of the following parameters: brain function activity, mental parameter and physiological parameter; - processing user data at least based on the received first user data; - assessment of the initial cognitive abilities of the user based on the processed user data; determination, based on the processed user data, the composition of the molecular complex and the formation of an individual program for the user to receive the molecular complex; - definition of a group of cognitive exercises based on user data and the formation of an individual program to complete a specific group of cognitive exercises;

sending the user instructions for receiving the selected molecular complex according to the generated individual program;

- sending at least one cognitive exercise to the user according to the generated individual program; - obtaining and evaluating the results of the user performing at least part of the cognitive exercises according to the generated individual program; - after completing an individual program for receiving a molecular complex by a user and completing an individual program of cognitive exercises, obtaining second user data, including at least one of the following parameters: activity of brain functions, mental parameter and physiological parameter; - processing user data at least based on the first and second user data and evaluating the results of the restoration of brain functions.

An embodiment of the inventive method is possible in which at the stage of obtaining the first user data, at least one of the following parameters is additionally obtained: user sleep parameters, genetic parameters, biological age, psychological age, body fluid analysis data, said at least one additional The obtained parameters are additionally used at the stage of processing the first user data.

Additionally, the proposed method includes obtaining the first user data by at least one of the following methods: manually entering data, extracting user data from a previously created database.

Additionally, in the proposed method, the parameter of brain activity is determined by at least one diagnosis from the following: psychological diagnosis, blood test, DNA analysis, diagnosis of MRI, EEG, ultrasound scan, ultrasound, ECG.

Additionally, in the proposed method, the processing of user data is carried out on the basis of a pre-trained machine learning algorithm.

Additionally, in the proposed method, learning the machine learning algorithm is carried out on the basis of the training sample, and the training sample is obtained on the basis of at least one of the following: clinical studies of multiple users, the history of the automated recovery of brain functions of multiple users, according to the proposed method. Additionally, in the proposed method, the molecular complex contains at least a portion of the following molecules: Arginine, Phenylalanine, Gingko-Biloba, Acetyl-L-carnitine, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), Lecithin, Fosatidilserin.

Additionally, in the proposed method, the formation of an individual program for performing a certain group of cognitive exercises is carried out additionally taking into account the individual program of user reception of the molecular complex.

Additionally, in the proposed method, the group of cognitive exercises includes at least one exercise of the following types of exercises according to functional affiliation: memory, attention, thinking, information processing speed, emotional control.

Additionally, in the proposed method, before sending at least one cognitive exercise to the user, data is received about the start of receiving the molecular complex by the user.

Additionally, in the proposed method additionally receive confirmation of compliance by the user with an individual plan for the reception of the molecular complex.

Additionally, in the proposed method in response to non-compliance by the user with an individual plan for the intake of the molecular complex, an individual program for performing a certain group of cognitive exercises is adjusted.

Additionally, in the proposed method at the stage of obtaining and evaluating the results of the user performing at least part of cognitive exercises according to the individual The program additionally carries out the adjustment of an individual program for receiving a molecular complex by a user.

Additionally, in the proposed method, at the stage of obtaining and evaluating the results of the user performing at least part of the cognitive exercises according to the generated individual program, the individual program for performing a certain group of cognitive exercises is additionally adjusted.

Additionally, in the proposed method, at the stage of obtaining and evaluating the results of the user performing at least part of the cognitive exercises according to the generated individual program, at least one of the following current user parameters is additionally obtained: activity of brain functions, mental parameter and physiological parameter.

Additionally, in the proposed method, the individual program of receiving the molecular complex by the user and / or the individual program of performing a certain group of cognitive exercises are adjusted, taking into account the obtained at least one current user parameter.

According to another aspect, a computer device for automatically restoring brain functions is provided, including a processor configured to implement the proposed method, including: obtaining first user data including at least one of the following parameters: brain function activity, mental parameter, and physiological parameter; - processing user data at least based on the received first user data; - assessment of the initial cognitive abilities of the user based on the processed user data; definition based on processed user data, the composition of the molecular complex and the formation of an individual program for the user to receive the molecular complex; - definition of a group of cognitive exercises based on user data and the formation of an individual program to complete a specific group of cognitive exercises;

- sending the user instructions for receiving the selected molecular complex according to the generated individual program;

- sending at least one cognitive exercise to the user according to the generated individual program; - obtaining and evaluating the results of the user performing at least part of the cognitive exercises according to the generated individual program; - after completing an individual program for receiving a molecular complex by a user and performing an individual program of cognitive exercises, obtaining second user data including at least one of the following parameters: activity of brain functions, mental parameter and physiological parameter; - processing user data at least based on the first and second user data and evaluating the results of the restoration of brain functions.

The well-known influence of various combinations of molecular sets on the functioning of the brain, cognitive functions, memory functions allows us to conclude that combinations of molecular sets are advisable to use in parallel with the use of cognitive training techniques to restore brain functions, as well as preventive protection against dementia diseases and generally improving the functioning of the human brain functions. The basic principle of compiling the molecular complex is to optimize the basic mechanisms of the brain and nervous system, which complements providing a natural molecular process due to substances necessary for normal cell growth, regeneration and natural full functioning, in combination with cognitive training. In this case, the psychoactive properties of stimulants, drugs, and other substances that are often misused to develop the intellectual potential of the brain or accelerated brain function are not used.

The proposed method allows to increase the efficiency of restoration of brain functions, taking into account the optimal use of the combination of the molecular course and the course of cognitive exercises, as well as to automate the process of appointing and monitoring the molecular course and cognitive exercises.

Brief Description of the Drawings

In FIG. 1 is a flowchart illustrating a method for automatically restoring brain functions.

The implementation of the invention

Various terms relating to aspects of the present invention and used in the text of the materials of the present application for the invention should be interpreted in their usual meaning used in the art, unless otherwise indicated.

In particular, the term "user" means a person who has chosen to use the proposed method in order to improve their cognitive abilities.

In particular, the term "first user data" refers to user parameters, including activity of brain functions, mental parameter, physiological parameter. Wherein it is possible to select one or more mental and / or physiological parameters, as well as one or more parameters of brain activity.

User sleep parameters may include periods of user activity, which can be used to select the optimal schedule for taking the molecular complex and / or performing cognitive exercises.

Body fluid analysis data may include, in particular, a blood test, analysis of a user's cerebrospinal fluid, etc. These parameters allow you to more accurately determine the current state of the user and select the necessary program to restore brain functions.

Biological and psychological age allow you to more accurately classify the user and select the optimal program of the molecular complex and / or cognitive exercises.

The parameter of brain activity can include both an assessment of cognitive abilities and an assessment of the mental state.

The first user data can be obtained by first testing the user before using the proposed method according to the invention. During initial testing, the patient may be asked to complete a series of exercises to determine the level of cognitive and psychophysical parameters. These can be at least tests to determine the user's ability to concentrate attention and reserves of his memory.

Alternatively or additionally, the first data can be entered manually by the user, for example, by entering the data on his mental, mental and physical state by the user on the proposed scale, for example, a ten-point scale, or by answering a number of questions, or by passing the test. Since the user’s assessment of his own cognitive abilities may be subjective, additional questions may be offered to the user in order to eliminate contradictions. In some embodiments, the user may be prompted to alternatively or additionally enter the name of the diagnosis made by a specialist physician.

The brain activity parameter can be determined using the following types of diagnostics: psychological diagnostics, blood analysis, DNA analysis, MRI, EEG, ultrasound, ultrasound, ultrasound, and other. Psychological parameters can be determined during psychological diagnostics, as well as additionally or alternatively using MRI, EEG, ultrasound scan, ultrasound, ECG. Physiological parameters can also be determined by analysis of blood and other biological materials, DNA analysis, determination of biological age as a general condition of the body, diagnosis of MRI, EEG, ultrasound scan, ultrasound, ECG.

According to one embodiment of the present technical solution, the processing of the first user data is carried out on the basis of a pre-trained machine learning algorithm. Learning machine learning algorithm is carried out on the basis of a training sample, which can represent at least one of the following: clinical studies of many users, the history of the automated restoration of brain functions of many users obtained during the implementation of the proposed method.

The processed user data is the basis for the selection of the specific composition of the molecular complex and the formation of an individual program for the user to receive the molecular complex.

The molecular complex may be a combination of dietary supplements, including vitamins and antioxidants, selected based on processed user data. Dietary supplements are represented by the following compounds.

EPA / DHA (Eicosapentaenoic Acid and Docosahexaenoic Acid, respectively), which belong to the polyunsaturated basic fatty acids (PUFA, Vitamin F) and are part of the omega-3 family, are important structural components of the phospholipid membranes of the tissues of the whole body, prevail in the tissues of the brain and nervous system. The amount of DHA in most human tissues is small, but in the brain it amounts to 36.4% of all fatty acids. EPA and DHA in the body appear due to the conversion of alpha-linolenic acid (ALA). EPA, in turn, is the "parent" of the third series of prostaglandins. They are necessary for the proper growth and functioning of the human body. In addition, eicosanoids (prostaglandins, prostacyclins, thromboxanes, and leukotrienes) are synthesized from them - local tissue hormones. They are created in cells and regulate cellular and tissue functions (platelet concentration, inflammatory reactions and white blood cell function, vasoconstriction and expansion, blood pressure, bronchial contractions and uterine contractions). As scientific studies prove, EPA and DHA support the normal functioning of the brain and provide a positive psycho-emotional mood. Therefore, they are essential nutrients (for example, see htp: //ruscaps.com/novosti/obzor-novykh-darmykhpo-omega-3-zhimym- kislotam /)

Another biological supplement is lecithin. Lecithin is a mixture of phospholipids (choline, inositol, etc.), vital for every cell of the human body. The need for lecithin of the human body is about 9 g per day. With food, a person receives it only 1/3 of the need. The human body synthesizes lecithin in extremely small quantities, which make up a small part of the daily dose necessary for a person, while a very large amount is consumed during physical and psycho-emotional stress. Thus, the need of the human body for lecithin is very high.

Lecithin is one of the main components of cell membranes, as well as protective membranes of the brain, muscle and nerve cells. Lack of lecithin can lead to constant fatigue, increased irritability. That is why it is so important to replenish the diet with lecithin if its reserves in the body are insufficient, for example, due to aging of the body or an increased level of stress. Lecithin is especially necessary for the elderly, since over the years, the lecithin content in the body decreases. Lecithin plays a crucial role in maintaining the functions of the brain, it is necessary for memory impairment. Approximately 30% of dry brain mass and

17% of the nervous system consists of lecithin. Lecithin is necessary for the synthesis of acetylcholine, the most important neurotransmitter of the human body, the lack of which leads to memory impairment and a decrease in mental and mental activity. Lecithin is needed for normal functioning of the nervous system, takes an active part in the transmission of nerve impulses, is useful for increased nervous excitability (for example, see https: //www.natural-

Another important dietary supplement is acetyl-b-carnitine. The human body produces 25% of the daily requirement of carnitine from lysine and methionine, vitamins C, B3 and B6 and iron. A deficiency of any of these substances leads to a deficiency of carnitine. The remaining 75% of the daily need for carnitine should be obtained from food. The name "carnitine" (from the Latin word "sago" - meat) indicates the main source of this amino acid. Most carnitine is found in meat, poultry, and seafood. Carnitine is found in small quantities in grains, fruits, and vegetables. Recommended levels of consumption of L-carnitine: for adults - 300 mg / day; for children 4-6 years old - 60-90 mg / day; for children 7-18 years old from 100 to 300 mg / day (according to the Ministry of Health of the Russian Federation).

However, with physical exertion and some diseases, the need for carnitine can increase several times. To get the required amount of L-carnitine, an adult needs to eat, for example, 400 g of beef daily. Acetyl-b-carnitine is a modified amino acid that supports the production of cellular energy and helps transport fats to the mitochondria, where they are oxidized and converted to ATP (chemical energy for cells).

Acetyl L-carnitine is a bioavailable form of L-carnitine that can cross the blood-brain barrier, where it has an antioxidant effect and helps maintain cellular energy metabolism and brain function. Having better digestibility and higher activity than simple carnitine, it is able to restore mental energy, improve mood, slow down brain cell aging and inhibit the onset of Alzheimer's disease. Besides, By energizing and balancing the central nervous system as a whole, it strengthens the defense against infections and

disorders of the immune system (https://medi.ru/info/10539/)

Another important dietary supplement is L-arginine. L-arginine - refers to conditionally essential amino acids. L-Arginine is one of the most effective stimulants for the production of growth hormone pituitary hormone (growth hormone), and allows you to maintain its concentration at the upper limits of the norm. Arginine is a donor and natural carrier of nitrogen, supplying nitrogen to a system of enzymes called NO synthases, which synthesize an NO group, which is a mediator of muscle relaxation of arterial blood vessels. The NO group is the main substance that regulates the tone of the vessels of the arterial bed, on which diastolic pressure depends. With a lack of Arginine and insufficient activity of NO synthases, the diastolic pressure increases; L-Arginine is involved in the cycle of transamination and excretion of the final nitrogen from the body, i.e., the breakdown product of waste proteins. From the power of the cycle (ornithine - citrulline - arginine) depends on the body's ability to create urea and cleanse from protein slags. L-Arginine is indicated for people after 30 years, because by this age, secretion from the pituitary gland almost completely ceases. A large amount of Nitric Oxide enters the brain and nerve endings. There, this compound is responsible for the transmission of nerve impulses, the regulation of mental activity. It helps to improve mood, makes a person more active, proactive and hardy, introducing a certain quality of mental energy into human behavior.

Another important dietary supplement is phosphatedylserine. According to studies, the daily dose of phosphatedylserine is 300 mg. The absolute majority of phosphotedylserine the body receives with food, but practically it is impossible to eat a sufficient amount of specific foods rich in this substance daily. Phosphotedylserine - is a soy phospholipid with a high content of phosphatidylserine, which is currently one of the highly effective natural neurometabolic agents. Phospholipids form the basis of all cell membranes, ensuring their fluidity and regulating the effectiveness of physiological processes. A special place among phospholipids is occupied by phosphatidylserine and phosphatidylcholine. Phosphatidylserine is found in the membranes of all body cells, while the highest concentrations of phosphatidylserine are observed in nerve cells. It plays a key physiological role in the differentiation of neurons, the processes of activation, regeneration, synthesis and release of neurotransmitters (acetylcholine, etc.), the movement of ions and conducting bioelectric current. Regulates nervous processes, including the processes of division and growth of nerve cells. It also promotes the activation of glucose metabolism in the brain and increases the resistance of nerve cells to ischemic damage. Phosphatidylserine inhibits the destruction of brain cells by microphages, inhibiting their phagocytic activity. It can pass through the blood-brain barrier and proceed directly into the brain tissue several minutes after ingestion. It stimulates the synthesis of acetylcholine and activates cholinergic processes in the brain. Meanwhile, a decrease in acetylcholine production is one of the natural phenomena in Alzheimer's disease and other types of senile dementia. An age-related decline in mental function occurs in parallel with a decrease in phosphatidylserine in the brain. Its use improves memory, learning ability, relieves depressed mood, stimulates overall activity, leads to significant shifts in the storage of information, the amount of memory. Clinical studies have shown significant improvement in memory and mood in 60-80 year olds with age-related memory impairment of varying degrees. According to the assessment of general intellectual status, patients who received phosphatidylserine (FS) were younger by about 12 years. Protects brain cells from aging, has a membrane protective effect, restores the structure of nerve tissue, improves brain cell metabolism (for example, see http: //www.mif-ua.com/archive/article/41481).

According to the above, the processed user data is the basis for determining the specific composition of the molecular complex and the formation of an individual program for receiving the molecular complex by the user.

In addition, the processed user data is the basis for determining a group of cognitive exercises and the formation of an individual program for performing a specific group of cognitive exercises. This takes into account

The list given in the present description of biological additives is not limited. As a non-limiting example of the combination of molecules that can be used as part of the course, the following combination can be given in general terms without specifying specific dosages and duration of administration: EPA / DHA fatty acids, phosphotedylserine, lecithin, acetyl-L-carnitine (Karnitsetin), L -phenylalanine, potassium / magnesium asparaginate, Gingko-Billoba extract, taurine, vitamin B1, vitamin B6 (pyridoxine), vitamin B 12 (cyanocobalamin).

The following are more detailed embodiments of the present technical solution with a description of therapy and a list of molecules of the molecular complex.

Additional non-limiting specific examples of possible elements of the molecular complex are given in the table below.

¹ -% of the recommended daily consumption level according to TP TS 022/2011 (Appendix 2).

² -% of an adequate level of consumption according to the Unified Sanitary and Epidemiological and Hygienic Requirements for Products (Goods) Subject to Sanitary and Epidemiological Surveillance (Control).

* - does not exceed the upper allowable level of consumption.

Scope: as a biologically active food supplement, source of L - arginine, L - phenylalanine, taurine, acetyl-L - carnitine, flavonoids in terms of rutin, omega-3 PUFAs (including eicosapentaenoic and docosahexanoic acids), vitamins (Bl, B6, B 12) containing phospholipids.

Directions for use: for adults, take 1 capsule of different colors 2 times a day, with meals. Duration of admission is 28 days. Contraindications: individual intolerance to the components of the product, phenylketonuria, pregnancy and lactation.

Justification of the composition.

The work of the central nervous system is a sequential excitation of nerve cells (neurons), which are combined into logical chains. The transmission of excitation from neuron to neuron is carried out by the release of chemicals-neurotransmitters. Different groups of neurons are activated by different neurotransmitters. Excitation of a neuron requires ATP energy. With intense mental work (or great emotional stress), ATP reserves are depleted, which is accompanied by fatigue. Normally, when tired, a person experiences a complex of subjective sensations, which is called fatigue. As a rule, a tired person stops thinking work (or reduces its intensity), which allows you to build up the ATP pool and stop fatigue. Fatigue can only be compensated by sleeping. However, highly motivated people can ignore the feeling of fatigue and continue to work despite fatigue. In this case, neurons continue to be excited in conditions of ATP deficiency. This leads to their gradual damage and loss of function. Outwardly, this is manifested in a decrease in the effectiveness of intellectual activity. The amount of short-term memory is reduced, which does not allow working with new information and carrying out creative activities. The ability to perform routine, familiar procedures is retained. However, the number of errors is increasing. Emotional lability also increases - anxiety, irritability appear. With prolonged ignoring of fatigue, dizziness, headache, fainting may appear. In the future, cardiovascular disorders, digestive problems and other somatic pathologies develop [Kosilov S. A., Leonova A. B. Human performance and ways to improve it. M.: Medicine, 1974. Navakatikyan A. O. Physiological mechanisms of fatigue // Physiology of labor activity / Ed. V.I. Medvedev. St. Petersburg: Nauka, 1993.S. 83-106 .; Platonov, G.G. Golubev. Psychology - M.: Higher School, 1977. - 263 p.].

It is known that low intellectual abilities are associated with insufficient inhibition of neuronal excitation. In this case, the neurons remain in an excited state for a long time, spend a lot of ATP, but provide “febrile”, ineffective thinking. Insufficient inhibition often develops against the background of psycho-emotional stress (deadlines, exams, force majeure, personal experiences). In conditions of fatigue, inhibitory neurons work worse, which increases the consumption of ATP and exacerbates fatigue.

Increasing intellectual endurance is achieved by improving the energy supply of neurons - at the level of blood circulation, at the level of glycolysis and at the level of mitochondrial oxidation. In this case, neurons can remain active longer and not get damaged. Another important approach is to stimulate the timely inhibition of the neuron in order to prevent its senseless fatigue.

These effects can be achieved using a number of pharmaceutical components:

Arginine

Proteinogenic amino acid. In the body, the amino acid arginine performs a number of functions: it helps to heal wounds, helps to remove excess ammonia from the body, stimulates the immune system and stimulates the secretion of a number of hormones, including glucagon, insulin and growth hormone. In free form, it is cleaved by NO synthase to nitric oxide. It has a multiple effect on the central nervous system. In the body, arginine is a precursor of nitric oxide, an endothelial factor, causing vasodilation and an increase in oxygen supply to the body, contributing to an improvement in the blood supply to the brain. In addition, nitric oxide is involved in the transfer of information between neurons. Preliminary studies have shown that arginine can help regulate cholesterol levels in the body. Arginine can also be considered as an antiplatelet agent.

It has been shown that administration of arginine to rats leads to improved learning by increasing memory. The introduction of NO synthase inhibitors leads to the opposite effect [B. A. Dubinin, S. S. Fedyushina, S. N. Stryukov et al. Effects of L-arginine and its functional antagonist I-nitro-L-arginine on behavior // Bull. an experiment. Biology and Medicine. — 1995. — T. 120, NQ 11.— S. 465-468., 5. Khavandgar S. The effect of L-NAME and Larginine on impairment of memory formation and state-dependent learning induced by morphine in mice // Psychopharmacology (Bed.) - 2003 .-- Vol. 167, M> 3. _. 291-296.].

Taurine

A widespread metabolite involved in many biochemical processes. The turnover of taurine in the body reaches tens of grams per day. Of particular importance for lipid metabolism. Taurine is used to enhance metabolic processes and to accelerate the restoration of damaged tissues. Taurine - 2-aminoethanesulfonic acid - a sulfur-containing amino acid. Taurine is not an essential amino acid for humans, although it is present in small amounts in the bile and muscles of humans and animals. Taurine is synthesized in the body in the brain and lungs with the participation of vitamin B6, an average of 50-125 mg / day. Taurine in the body is mainly in its free form. It is excreted in urine and bile. Regulation of renal reabsorption is the main mechanism for maintaining taurine homeostasis. Despite the endogenous synthesis of taurine, the need for its dietary intake remains. The functions of taurine are very extensive and diverse, the mechanism of most of them is poorly understood. One of the main functions of taurine is the stabilization of cell membranes and the improvement of metabolic processes. Taurine also provides conjugation of bile acids, preventing cholestasis. Taurine forms conjugates with bile acids in the liver (acylating at the amino group), the resulting conjugates (for example, taurocholic acid) form part of the bile and, as surface-active substances, contribute to the emulsification of fats in the intestines. Taurine also affects calcium and water homeostasis by determining blood pressure. Recently, it has been established that taurine plays the role of a neurotransmitter amino acid in the brain that inhibits synaptic transmission, has anticonvulsant activity, and also has a cardiotropic effect. Taurine reduces peroxide stress after training and increases the effectiveness of the training itself. Taurine helps improve energy processes, stimulates reparative processes in degenerative diseases. It normalizes processes, the violation of which is accompanied by a significant change in the metabolism of eye tissues. Therefore, taurine is necessary for the functioning of the retina.

Taurine inhibits the central nervous system neurons, suppressing excessive excitation and thus improving the quality of mental activity. The central nervous system is becoming more streamlined, there is a decrease in ATP consumption. There is the possibility of longer intellectual work until fatigue. In the case of severe fatigue of the central nervous system (or injury), neurons are damaged, and the cell loses electrolytes. Taurine reduces the occurring osmotic shock and allows the cell to survive. In animal experiments, it was shown that taurine protection protects neurons against the background of various types of damage: toxic, diabetic, starvation, age-related degeneration, mechanical trauma [Lu CL, Tang S, Meng ZJ, He YY, Song LY, Liu YP, Ma N, Li XY, Guo SC. Taurine improves the spatial learning and memory ability impaired by sub-chronic manganese exposure. J Biomed Sci. 2014 May 24; 21: 51. ; Agca CA, Tuzcu M, Hayirli A, Sahin K. Taurine ameliorates neuropathy via regulating NF-kV and Nrf2 / HO-l signaling cascades in diabetic rats. Food Chem Toxicol. 2014 Sep; 71: l 16-21 .; Curtis L, Epstein P. Nutritional treatment for acute and chronic traumatic brain injury patients.].

The introduction of taurine allowed us to normalize the central nervous system, even against the backdrop of such a complex condition as alcohol withdrawal [Razvodovsky et al. The effect of taurine on the content of neuroactive compounds in the central nervous system in case of alcohol withdrawal syndrome // Experimental and Clinical Pharmacology. Volume 70, N ° 5 (2007)].

Phenylalanine

Proteinogenic amino acid. Participates in the synthesis of one of the neurotransmitters - dopamine. He is responsible for generating incentives. With a decrease in dopamine transmission, apathy is observed, a decrease in interest in life. However, with age, more often than not deficiency is observed, but an excess of phenylalanine in the body, which leads to the development of neurodegenerative diseases [Wissmann P, Geisler

S, Leblhuber F, Fuchs D. Immune activation in patients with Alzheimer's disease is associated with high serum phenylalanine concentration j Neurol Sci. 2013

Jun 15; 329 (l-2): 29-33. ; Rudman D, Abbasi AA, Chaudry F, Mattson DE.

Delayed plasma clearance of phenylalanine and tyrosine in elderly men. J am

Geriatr Soc. 1991 Jan; 39 (l): 33-8.].

Rutin (gingo biloba extract is standardized according to it).

Rutin is a polyphenolic substance that has an antioxidant, anti-inflammatory and anti-hyaluronidase effect. It is incorrectly called vitamin P. It is assumed that taking rutin has an angioprotective effect. In this way he can improve blood circulation of the brain and increase the energy supply of neurons. It has been experimentally shown that in case of violation of the blood supply to the brain of rats, taking routine restores the cognitive functions of the animal [Qu J, Zhou Q, Du Y, Zhang W, Bai M, Zhang Z, Xi Y, Li Z, Miao J. Rutin protects against cognitive deficits and brain damage in rats with chronic cerebral hypoperfusion. Br J Pharmacol. 2014 Aug; 171 (15): 3702-15.]. In addition, it is assumed that rutin has a strong antioxidant effect, which reduces the damaging effect of free radicals during intensive mitochondrial work (when restoring ATP neuron reserves). In model experiments, it was shown that rutin intake has an antioxidant effect and spatial memory improvement in aging rats [Pyrzanowska J, Piechal A, Blecharz-Klin K, Joniec-Maciejak I, Zobel A, Widy-Tyszkiewicz E. Influence of long-term administration of rutin on spatial memory as well as the concentration of brain neurotransmitters in aged rats. Pharmacol Rep. 2012; 64 (4): 808-16.

Ginkgo biloba extract may have a nootropic effect. The mechanism is unknown, but it is believed that ginkgo affects the activity of some neurotransmitters. In addition, the extract has a neuroprotective effect, protecting neurons damaged by ischemia or peroxide stress. There are clinical data confirming the effectiveness of the extract in relation to cognitive functions. In one placebo-controlled study, the effect of taking the extract on the mental functions of older people (50-59 years old) was shown. An increase in short-term memory was recorded with a two-day intake of 28. A similar effect on improving memory was recorded in young healthy (average age 32 years) volunteers with a single dose. Effective dosages from 30 to 150 mg of extract, calculated as rutin [Hindmarch SZ: The psychopharmacological effects of

Ginkgo biloba extract in normal healthy volunteers. Int J Clin Pharm Res 1984; IV: 89-93]. In addition to improving memory, young volunteers increased the “speed of attention” and persisted for 2-6 hours after taking 60-90 mg of extract in terms of routine 30. There are also works with a negative result, in which no result was shown. Published meta-analyzes of accumulated data (including the Cochrane authoritative meta-analysis) indicate the effectiveness of the extract. All effects shown were dose dependent. Significant side effects were not observed.

Acetyl carnitine

The active form of organic acid, ready for transport to the mitochondria of the brain. Highly efficient energy substrate.

Quickly restores ATP neurons and reduces fatigue. While taking acetyl-carnitine, there is an increase in cognitive endurance.

The effect is best shown on healthy elderly people whose intellectual stamina is greatly reduced. After administration, a significant significant improvement in cognitive functions was observed, physical strength also increased, and sleep was normalized

[Malaguarnera Ml, Gargante MP, Cristaldi E, Colonna V, Messano M,

Koverech A, Neri S, Vacante M, Cammalleri L, Motta M. Acetyl L-carnitine

(ALC) treatment in elderly patients with fatigue. Arch Gerontol Geriatr. 2008

Mar-Apr; 46 (2): 181-90]. The effect of acetyl-carnitine against age-related diseases is even stronger. It was shown that taking 2000-3000 mg / day of acetylcarnitine significantly increases cognitive function in both discirculatory encephalopathy and Alzheimer's disease.

[Gavrilova SI, Kalyn IaB, Kolykhalov IV, Roshchina IF, Selezneva ND. [Acetyl-

L-carnitine (carnicetine) in the treatment of early stages of Alzheimer's disease and vascular dementia]. Zh Nevrol Psikhiatr Im S S Korsakova.

2011; lll (9): 16-22.]. In addition, the use of acetyl-carnitine improves cognitive function in encephalopathy associated with impaired liver function [Malaguarnera M, Vacante M, Motta M, Giordano M, Malaguarnera G, Bella R, Nunnari G, Rampello L, Pennisi G. Acetyl-L-carnitine improves cognitive functions in severe hepatic encephalopathy: a randomized and controlled clinical trial. Metab Brain Dis. 2011 Dec; 26 (4): 281-9.]. In very elderly people (-100 years old), a single dose of 2000 mg of carnitine (unleaded form) led to an immediate improvement in cognitive functions and an increase in intellectual endurance [Malaguarnera M, Cammalleri L, Gargante MP, Vacante M, Colonna V, Motta ML-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial. Am J Clin Nutr. 2007 Dec; 86 (6): 1738-44.].

Vitamin B1

Cofactor of carbohydrate metabolism enzymes. It is required to obtain ATP from glucose - the main energy substrate of the nervous system. In addition, vitamin B 1 is required for the disposal of an exciting neurotransmitter - glutamate. With a deficiency of vitamin B1, first of all, damage is observed first to the peripheral, and then the central nervous system. Even a small deficiency of thiamine leads to a violation of carbohydrate metabolism in the brain and, as a result, a decrease in cognitive functions [Gibson GE, Hirsch JA, Fonzetti P, Jordan BD, Cirio RT, Elder J. Vitamin B1 (thiamine) and dementia. Ann N Y Acad Sci. 2016 Mar; 1367 (1): 21-30.]. It has been shown that a high level of the active metabolite of vitamin B1 - thiamine diphosphate in the elderly reduces the likelihood of developing neurodegenerative disorders [Wang C, Fei G, Pan X, Sang S, Wang L, Zhong C, Jin L. High thiamine diphosphate level as a protective factor for Alzheimer's disease. Neurol Res. 2018 May 2: 1-8.]. In case of neuronal damage (with all forms of overwork and exhaustion), the Ambulance must first administer vitamin B 1 and only then glucose.

Vitamin B6 It is a cofactor of enzymes (in the form of pyridoxalphosphate it is part of enzymes that catalyze decarboxylation and transamination). Thus, vitamin B6 is required for the synthesis of most neurotransmitters: glutamate, GABA, etc. It is actively used in the treatment of peripheral neuropathies, but has not been used for cognitive impairment. At the same time, animal experiments have shown that deficiency of vitamins B6 (and B 12) accelerates the development of age-related cognitive impairment [Nuru M, Muradashvili N, Kalani A, Lominadze D, Tyagi N. High methionine, low folate and low vitamin B6 / B12 (HM-LF-LV) diet causes neurodegeneration and subsequent short-term memory loss. Metab Brain Dis. 2018 Aug 9.].

Vitamin B12

Cofactor of two enzymes. Deficiency of vitamin B 12 leads to an increase in homocysteine, which has a destructive effect on blood vessels. Data on humans and animals show that vitamin B 12 (and B6) deficiency accelerates the development of age-related cognitive impairment [Nuru M, Muradashvili N, Kalani A, Lominadze D, Tyagi N. High methionine, low folate and low vitamin B6 / B12 (HM -LF-LV) diet causes neurodegeneration and subsequent short-term memory loss. Metab Brain Dis. 2018 Aug 9.]. Vitamin B 12 intake can stop the occurring disorders [Moore E, Mander A, Ames D, Came R, Sanders K, Watters D. Cognitive impairment and vitamin B12: a review. Int Psychogeriatr. 2012 Apr; 24 (4): 541-56.]. Cognitive problems not related to deficiency of B12 are not affected by this vitamin.

Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)

OMEGA-3 polyunsaturated fatty acids (PUFAs) are indispensable for the normal functioning of human cells, they are not synthesized in the body and must come from the outside with food. The source is some varieties of marine fish: salmon, tuna, sardine. The main and most studied representatives of the OMEGA-3 family of PUFAs are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).

The main mechanisms of action of OmegaZ PUFAs [Titova VN, Lisitsyn DM. Fatty acid. Physical chemistry, biology and medicine. Triad. M. 2006, 268 p .; Benatti R., Peluso G., Nicolai R., Calvani M. Polyunsaturated Fatty Acids: Biochemical, Nutritional and Epigenetic Properties. Review Journal of the American College of Nutrition. 2004, v. 23, Ns 4, 345-370; Solakivi T et al, Strukova S. Blood coagulation — dependent inflammation. Coagulation — dependent inflammation and inflammation — dependent thrombosis. II Frontiers in Bioscience. 2005, N ° ll, 59-80]:

• suppression of the synthesis of pro-inflammatory eicosanoids (prostaglandins 2 and leukotrienes 4 series) from AK;

• activation of the synthesis of anti-inflammatory eicosanoids (prostaglandins 3 and 5 series leukotrienes) from Omega-3 PUFAs;

• decrease in the production of platelet aggregation factor, tumor necrosis factor 7 and interleukin 1;

• suppression of the effect on the erythrocyte growth factor (PDGF), reduction of red blood cell aggregation, stimulation of relaxation of endothelial cells of the blood vessel walls;

• normalization of lipid metabolism (a decrease in the level of triglycerides (TG) and very low density lipoproteins (VLDL) in blood plasma, an increase in the level of high density lipoproteins (HDL).

Thanks to the above-described mechanisms of action, Omega-3 PUFAs have a wide range of clinical and pharmacological effects:

• normalize lipid metabolism;

• prevent the development of metabolic and cardiovascular disorders;

• improve rheological properties of blood and microcirculation; • regulate vascular tone;

• provide the production of anti-inflammatory prostaglandins (they prevent endothelial damage and the development of endothelial dysfunction).

Omega-3 PUFAs have anti-inflammatory, antithrombotic, anti-apoptotic and antioxidant effects, which can be achieved only with sufficient daily intake of omega-3 PUFAs in food and with special medications. Therefore, in many countries, norms have been introduced for the consumption of omega-3 PUFAs as an essential micronutrient.

Docosahexaenoic acid is a polyunsaturated w-3 fatty acid.

It is a structural component of cell membranes. It is concentrated mainly in the brain. A decrease in DHA intake leads to a decrease in the elasticity of the membranes of neurons and accelerate brain aging. In addition, it is a precursor of anti-inflammatory cytokines, thereby preventing the development of neurodegenerative diseases. In large

(176 people) the study showed that DHA intake by healthy people under 45 years of age led to an increase in event memory and, to a lesser extent, an increase in short-term memory \ Stonehouse Wl, Conlon

CA, Podd J, Hill SR, Minihane AM, Haskell C, Kennedy D. DHA supplementation improved both memory and reaction time in healthy young adults: a randomized controlled trial. Am J Clin Nutr. 2013 May; 97 (5): 1134-

43.]. But taking DHA has a stronger effect on an aging brain in older people. In a large (more than 400 patients) double-blind, randomized study, it was shown that taking 900 mg of DKG per day for six months improved event memory and increased learning in older people with reduced cognitive abilities [Yurko-Mauro K. Cognitive and cardiovascular benefits of docosahexaenoic acid in aging and cognitive decline. Curr Alzheimer Res. 2010

May; 7 (3): 190-6.]. In addition, it is known that high levels of DCG in the blood reduces the likelihood of developing Alzheimer's disease. Initial daily intake of 1.55 g of DHA + 0.4 g of EPA by patients over 65 with weak cognitive impairment led to improved speech (Initial Letter Fluency) and reduced the severity of senile depression [Sinn N, Milte CM, Street SJ, Buckley JD , Coates AM, Petkov J, Howe PR. Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: a 6-month randomized controlled trial. Br JNutr. 2012 Jun; 107 (11): 1682-93].

Eicosopentaenoic acid (EHL) is a polyunsaturated w-Z fatty acid. It is a structural component of cell membranes, including membranes of neurons. It is a precursor of anti-inflammatory cytokines. Being an omega-3 fatty acid, this component is considered necessary to prevent senile dementia. Taking 1.67 g of EPA + 0.16 g of DHA daily for six months by patients over 65 years of age with mild cognitive impairment reduced the severity of senile depression [Sinn N, Milte CM, Street SJ, Buckley JD, Coates AM, Petkov J, Howe PR. Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: a 6-month randomized controlled trial. Br J Nutr. 2012 Jun; 107 (11): 1682-93.].

Phospholipids.

A large family of polar lipids. They are a structural component of cell membranes, as well as blood lipid complexes. One of the main components of the membranes of neurons. In addition, phosphatidylcholine may be a source of choline for the synthesis of the neurotransmitter acetylcholine. It is known that age-related decline in cognitive function is often associated with a dietary deficiency of phospholipid components [van Wijk N, Slot RER, Duits FH, Strik M,

Biesheuvel E, Sijben JWC, Blankenstein MA, Bierau J, van der Flier WM,

Scheltens P, Teunissen CE. Nutrients required for phospholipid synthesis are lower in blood and cerebrospinal fluid in mild cognitive impairment and Alzheimer's disease dementia. Alzheimers Dement (Amst). 2017 May 16; 8: 139-146. \. Phosphatidylserine has a membrane stabilizing effect, at a dosage of 100 mg / day when taken from 1 month, it has some restoration of cognitive functions in age-related neurodegenerative diseases [Glade MJ, Smith K. Phosphatidylserine and the human brain. Nutrition 2015 Jun; 31 (6): 781-6. \.

As a non-limiting example of a group of cognitive exercises, the following exercises can be cited, containing tasks for determining and training the reaction rate, determining and training the following abilities: reaction time, visual perception, contextual memory, short-term memory, short-term visual memory, working memory, information processing speed, focused attention, auditory perception, auditory memory, non-verbal memory, recognition, planning, hand-eye coordination, etc. spatial perception, the ability to estimate.

The method according to the proposed invention includes the following types of therapeutic effects. The main type of therapeutic effect is cognitive therapy, which is a set of therapeutic and prophylactic measures aimed at developing the user's own intellectual and mnestic potential by increasing knowledge and skills in the field of control and management of their own cognitive functions, control of psycho-emotional activity, as well as the development of subject life skills, erudition and the general outlook of a person. For the purposes of this application, the term “cognitive therapy” primarily includes cognitive training and exercise to strengthen the mental functions of the brain. The next type of therapy is reduction therapy, which is a therapeutic and preventive measure aimed at restoring the functions of enzymes by introducing cofactors into the body, including vitamins, minerals and other biologically active additives. Another type of therapy is additive therapy, which is the introduction into the body of deficient products of an intermediate metabolite, for example, vitamins and essential amino acids that are not synthesized in the human body, while the metabolism and energy in the human body can be restored. Both reduction therapy and additive therapy are varieties of metabolic therapy.

Detoxification therapy is a complex of therapeutic and preventive measures in which numerous methods of neutralizing, eliminating and eliminating the accumulated pathogenic metabolites and metabolic products from the body are considered. Anti-ischemic and antihypoxic therapy are therapeutic measures directed against exogenous and endogenous hypoxia, as well as to reduce the risks of developing ischemic pathologies.

In addition, an additional type of therapeutic effect is the normalization of synaptic processes, which is a complex of treatment and prophylactic measures aimed at ensuring the normal natural functioning of the synaptic mechanisms of neural interaction and, as a result, to improve neurotransmission.

Another therapeutic effect is therapy to enhance neurogenesis - a set of treatment and prophylactic measures aimed at ensuring a multi-stage process of the formation of new nerve cells and interneuronal interactions in the mature central nervous system. A method for the automated restoration of brain functions is carried out on a computer device, while the proposed method includes the following steps.

The computer device may be, for example, a server configured to exchange data with a user device over a data network. The user device is associated with the user and can be, for example, a smartphone, computer, laptop, tablet computer, smart watch, glasses or other device that provides input and output data to the user, as well as data exchange with the server.

Further, the inventive method will be considered in an illustrative non-limiting example, which serves for the purpose of explaining the main steps. The method includes the following main steps.

Step 301. The computer device obtains the first user data including at least one of the following parameters: activity of brain functions, mental parameter, and physiological parameter.

At step 301, the first data of the “Patient 1” user is obtained, which may include MRI diagnostic results, EEG diagnostic results as a parameter of the brain function activity, and a Mini Mental State Examination (MMSE) short scale for assessing mental status as a mental parameter, as a physiological parameter - the results of blood and urine tests.

According to a non-limiting example of implementation, the first data of “Patient 1” is as follows: MRI diagnostics, EE diagnostics, brain bioelectrical activity reactivity (BEA), MMSE diagnostics - 28 points, which is normal and means that there is no cognitive impairment, the results according to the memorization technique 10 words A. L. Luria - 60%, frontal battery results dysfunction - 60%; results of memory research by memorizing short phrases - 50%; assessment of the subjective state on a 10-point scale: memory - 7 points, attention - 6 points, thinking - 5 points, mood - 5 points; blood and urine test results.

Step 302. Processing the user data at least based on the received first user data.

Diagnostics on the MMSE scale - 28 points, the results according to the method of memorizing 10 words by A. L. Luria - 60%, the results of the test "battery of frontal dysfunction" - 60%; results of memory research by memorizing short phrases - 50%; assessment of the subjective state on a 10-point scale: memory - 7 points, attention - 6 points, thinking - 5 points, mood - 5 points; blood and urine tests - no significant changes.

Step 303. Evaluation of the initial cognitive abilities of the user based on the processed user data.

Assessment of the cognitive abilities of "User 1" based on the processed data shows that the results of MRI diagnostics show signs of moderate hydrocephalus of the anterior parts of the brain, without signs of intracranial hypertension, signs of posthypoxic changes in the cerebral cortex of a moderate nature; EEG diagnostic results show moderate diffuse changes in the bioelectrical activity of the brain, mainly in the prefrontal areas, signs of pronounced disorganization of the bioelectric activity of the brain, mainly in the anterior regions; the reactivity of the bioelectric activity of the brain (BEA) during functional tests is expressed; diagnostic results on the MMSE scale show the norm and mean the absence of cognitive impairment; short-term memory below normal, there is a violation of memorization, slowdown associative processes, physiologically significant changes are not available.

Step 304. Determination of the molecular complex composition based on the processed user data and the formation of an individual program for the user to receive the molecular complex.

Based on the processed data, the composition of the molecular complex is determined, taking into account the nature of the dysfunction of the brain. In this non-limiting example, the revealed impaired brain functions are impaired memory, concentration of attention and thinking. Taking into account the revealed violations, the following components of the molecular complex were assigned and an individual program for the administration of the molecular complex was formed: 1) EPA / DHA fatty acids - 600/300 mg 2 times a day, for 30 days; 2) phosphotedylserine - 100 mg 2 times a day, for 30 days; 3) RS-Lecithin - 1200 mg 2 times a day, for 30 days; 40 Acetyl-L-carnitine (Karnitsetin) - 500 mg 2 times a day, for 30 days; 5) L-phenylalanine - 500 mg 2 times a day, for 30 days; 6) potassium / Magnesium Asparaginate - 140/158 mg 2 times a day, for 30 days; 7) Gingko-Biloba extract - 60 mg 2 times a day, for 30 days; 8) taurine - 200 mg 2 times a day, for 30 days; 9) B1 - thiamine - 100 mg 2 times a day, 30 days; 10) B6 - pyridoxine - 100 mg 2 times a day, for 30 days; 11) In 12 - cyanocobalamin - 0.20 mg 2 times a day, for 30 days.

Step 305. The definition of a group of cognitive exercises based on user data and the formation of an individual program to perform a specific group of cognitive exercises.

Based on the processed user data, a group of cognitive exercises is determined and an individual program is formed In this non-limiting embodiment, the revealed impaired brain functions are impaired memory, concentration of attention and thinking. Based on the identified violations, the following exercises are assigned and an individual program for the execution of a certain group of cognitive exercises is formed.

An exercise in perception speed, in particular, “User 1”, is invited to click on the numbers as soon as possible in ascending order from 1 to 25. The task runs for a while.

The exercise for training the memory (memory), in particular, “User 1” is invited to remember the maximum number from the list of words below for 7 seconds and find the maximum number from the given set of images corresponding to words from the list of words for 15 seconds.

An exercise in memory training (recollection), in particular, “User 1”, is invited to listen to two different texts for two minutes at the same time in two different voices: men and women. Further, “User 1” is invited to answer questions on the subject of texts with a choice of answer options.

The exercise of training visual memory (visual memory), in particular, “User 1” is invited to carefully consider the first slide with the image, close your eyes for a few seconds, then open them and describe the image in detail. Then, “User 1” is invited to consider the second slide with a set of words, then select those words that correspond to the objects in the image from the first slide.

The exercise in training the reaction speed (false color), in particular, to User 1, is shown the image of the word as the name of a color, while the meaning of the word as the color name is different from the color in which the word is executed. To user 1 It is proposed to indicate the name of the color in which the word is executed as quickly as possible. During the exercise "User 1" should not confuse the words in the form of the name of the color and the color in which the word is made. When performing this exercise, both hemispheres of "User 1" work simultaneously, namely the left hemisphere performs the function of reading, and the right tracks color.

Exercise training on attention (retention), in particular the "User 1" is offered carefully listen to some stories, ^"for example, from 2 to 5 stories, and answer questions about the story Listen to the story.

The exercise of training hand-eye coordination (double management), in particular, “User 1” is invited to draw the desired images simultaneously with two hands, namely draw two different figures (square, circle, triangle in pairs in three variations, respectively) with two hands at the same time, then each hand has a separate figure.

The exercise of training hand-eye coordination (mirror drawing), in particular, “User 1” is invited to draw letters and symbols with two index fingers at the same time, in a mirror-symmetric display.

An exercise in training the ability to evaluate (search synopsis), in particular, “User 1” is offered the name of an object or phenomenon, for example, “wind” and is invited to give him the most accurate scientific definition, which includes all the essential features. Mental training (visual meditation), in particular

“User 1” is offered a training, during which “User 1” is required intensive, deep reflection, “immersion” in the subject, an idea that is achieved by concentration at one object using not only visual meanings, but also feelings: taste, touch, smell and sound.

The study of new information (new knowledge), in particular, “User 1” is invited to familiarize themselves with the information, study material from the field of knowledge, which most attracts “User 1”, but at the same time remains completely unexplored “User 1”. For example, it may be the study of a quantum hypothesis, or the study of a foreign language that has not previously been studied by "User 1".

The exercise for training information processing (general symptoms), in particular, “User 1” is invited to familiarize yourself with two randomly selected words that are not related to each other, such as “plate” and “boat”. "User 1" is invited to select the maximum number of common features for these things. General characteristics selected by “User 1” may be, for example, the following “product made by human hands”. The unusual responses of “User 1” are particularly appreciated, for example, allowing you to see objects from a different perspective. When scoring an exercise, an originality score may be added.

Breath management, in particular, “User 1” is invited to consciously control their breathing for a short time under the control of an audio guide and specific sounds aimed at entering the Alpha rhythm.

Moreover, in this non-limiting embodiment, the exercises are divided into two blocks, the first of which is the primary recommended implementation by "User 1" without fail, and the second block is recommended as an additional one.

In the non-limiting embodiment in question, the travel time can also be determined. cognitive training, including the implementation of all exercises as part of an individual program. In particular, the execution of exercises is distributed in time so that the first block of exercises is recommended for execution by "User 1" within 2/3 of the time allotted for cognitive training, and the second block of exercises is recommended to be performed within 1/3 of the time allotted for cognitive training.

Step 306. Sending the user instructions for receiving the selected molecular complex according to the generated individual program.

At step 306, instructions are sent to the user for selecting the molecular complex determined at step 304. Instructions for receiving the molecular complex are displayed to the user on the screen of the electronic device.

Step 307. Sending at least one cognitive exercise to the user according to the generated individual program.

At step 307, the user is sent at least one cognitive exercise according to the generated individual program at step 305. Examples of cognitive exercises are given above in the application with respect to step 305, the cognitive exercises themselves are displayed to the user on the screen of the electronic device, and at the same time the user performs at least one cognitive exercise according to the specified formed individual program.

Step 308. Obtaining and evaluating the results of the user performing at least part of the cognitive exercises according to the generated individual program.

At step 308, the result of the user performing at least one cognitive exercise is obtained. Cognitive there may be more exercises, therefore, it is possible to obtain an assessment of the user's performance of at least part of the cognitive exercises according to the individual program formed. Assessment of the performance of cognitive exercises by the user can be carried out using the same parameters, including the results of brain MRI diagnostics, the results of EEG diagnostics as a parameter of the activity of the brain, as a mental parameter - a short scale for assessing mental status (Mini Mental State Examination - MMSE), as a physiological parameter - the results of blood and urine tests.

Step 309. After completing an individual program for receiving a molecular complex by a user and completing an individual program of cognitive exercises, obtaining second user data including at least one of the following parameters: activity of brain functions, mental parameter, and physiological parameter.

At step 309, second user data is obtained, which is user data processed based on the results of cognitive exercises performed by "User 1", as well as taking into account the parameters used in steps 301 and 309.

Step 310. Processing user data based at least on the first and second user data and evaluating the results of the restoration of brain functions.

At 310, user data is processed based at least on the first and second user data. Processing the first and second data of "User 1" preferably includes the operation of comparing the first data and second data of "User 1". Thus, the characteristic of improving the functioning of the brain of "User 1" can be obtained. The presented illustrative embodiments, examples and description serve only to provide an understanding of the claimed technical solutions and technologies and are not limiting. Other possible embodiments will be apparent to those skilled in the art from the description provided. The scope of the present invention is limited only by the attached claims.

Claims

CLAIM

1. A method for automated restoration of brain functions, carried out on a computer device, including:

- obtaining the first user data, including at least one of the following parameters: activity of brain functions, mental parameter and physiological parameter;

- processing user data at least based on the received first user data;

- assessment of the initial cognitive abilities of the user based on the processed user data;

- determining, based on the processed user data, the composition of the molecular complex and the formation of an individual program for the user to receive the molecular complex;

- definition of a group of cognitive exercises based on user data and the formation of an individual program to complete a specific group of cognitive exercises;

- sending at least one cognitive exercise to the user according to the generated individual program;

- obtaining and evaluating the results of the user performing at least part of the cognitive exercises according to the generated individual program;

- after completing an individual program for receiving a molecular complex by a user and completing an individual program of cognitive exercises, obtaining second user data including at least one of the following parameters: activity of brain functions, mental parameter and physiological parameter;

- processing user data at least based on the first and second user data and evaluating the results of the restoration of brain functions.

2. The method according to claim 1, in which at the stage of obtaining the first user data, at least one of the following parameters is additionally obtained: user's sleep parameters, genetic parameters, biological age, psychological age, body fluid analysis data, said at least one of the additionally obtained parameters are additionally used at the stage of processing the first user data.

3. The method according to claim 1, wherein obtaining the first user data is carried out by at least one of the following methods: manually entering data, extracting user data from a previously created database.

4. The method according to p. 1, in which the parameter of brain activity is determined by at least one diagnosis from the following: psychological diagnosis, blood test, DNA analysis, diagnosis of MRI, EEG, ultrasound scan, ultrasound, ECG.

5. The method according to claim 1, in which the processing of user data is carried out on the basis of a pre-trained machine learning algorithm.

6. The method according to claim 5, in which the learning machine learning algorithm is carried out on the basis of the training sample, and the training sample is obtained on the basis of at least one of the following: clinical studies of multiple users, the history of automated recovery of brain functions of multiple users, according to the method according to claim 1.

7. The method according to claim 1, in which the molecular complex contains at least a portion of the following molecules: Arginine, Phenylalanine, Gingko-Biloba, Acetyl-L-carnitine, eicosapentaenoic acid (EHL) and docosahexaenoic acid (DHA), Lecithin, Fosatidylserin .

8. The method according to LP, in which the formation of an individual program for performing a certain group of cognitive exercises is carried out additionally taking into account the individual program of user reception of the molecular complex.

9. The method according to claim 1, in which the group of cognitive exercises includes at least one exercise of the following types of exercises according to functional affiliation: memory, attention, thinking, information processing speed, emotional control.

10. The method according to claim 1, in which before sending at least one cognitive exercise to the user, data is received about the start of the reception of the molecular complex by the user.

11. The method according to claim 1, in which additionally receive confirmation of compliance by the user with an individual plan for the reception of the molecular complex.

12. The method according to claim 11, in which in response to non-compliance by the user of an individual plan for the reception of the molecular complex, adjustment of an individual program for performing a certain group of cognitive exercises.

13. The method according to p. 1, in which at the stage of obtaining and evaluating the results of the user performing at least part of the cognitive exercises according to the generated individual program, the individual program of receiving the molecular complex by the user is additionally adjusted.

14. The method according to p. 1, in which at the stage of obtaining and evaluating the results of the user performing at least part of the cognitive exercises according to the generated individual program, the individual program of performing a certain group of cognitive exercises is further adjusted.

15. The method according to p. 1, in which at the stage of obtaining and evaluating the results of the user performing at least part of the cognitive exercises according to the generated individual program, they additionally receive at least one of the following current user parameters: activity of brain functions, mental parameter and physiological parameter, subjective assessment of the state by the user,

16. The method according to clause 15, in which additionally carry out the adjustment of the individual program of reception by the user of the molecular complex and / or the adjustment of the individual program of performing a certain group of cognitive exercises, taking into account the obtained at least one current parameter of the user.

17. A computer device for the automated restoration of brain functions, including a processor, configured to implement the method according to claims. 1-16.