WO2020072126A3 - Modulating ptpn2 to increase immune responses and perturbing gene expression in hematopoietic stem cell lineages - Google Patents

Modulating ptpn2 to increase immune responses and perturbing gene expression in hematopoietic stem cell lineages Download PDF

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Publication number
WO2020072126A3
WO2020072126A3 PCT/US2019/045067 US2019045067W WO2020072126A3 WO 2020072126 A3 WO2020072126 A3 WO 2020072126A3 US 2019045067 W US2019045067 W US 2019045067W WO 2020072126 A3 WO2020072126 A3 WO 2020072126A3
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Prior art keywords
ptpn2
gene expression
modulating
cell lineages
stem cell
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PCT/US2019/045067
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French (fr)
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WO2020072126A2 (en
WO2020072126A8 (en
Inventor
William N. HAINING
Arlene H. Sharpe
Martin Lafleur
Thao Nguyen
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Dana-Farber Cancer Institute, Inc.
President And Fellows Of Harvard College
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Application filed by Dana-Farber Cancer Institute, Inc., President And Fellows Of Harvard College filed Critical Dana-Farber Cancer Institute, Inc.
Priority to US17/265,934 priority Critical patent/US20220081691A1/en
Publication of WO2020072126A2 publication Critical patent/WO2020072126A2/en
Publication of WO2020072126A8 publication Critical patent/WO2020072126A8/en
Publication of WO2020072126A3 publication Critical patent/WO2020072126A3/en

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Abstract

The present invention relates, in part, to methods of treating a subject with a condition that would benefit from an increased immune response comprising administering to the subject a therapeutically effective amount of an agent that inhibits PTPN2. The present invention also provides methods and compositions for perturbing gene expression in hematopoietic cell lineages.
PCT/US2019/045067 2018-08-07 2019-08-05 Modulating ptpn2 to increase immune responses and perturbing gene expression in hematopoietic stem cell lineages WO2020072126A2 (en)

Priority Applications (1)

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US17/265,934 US20220081691A1 (en) 2018-08-07 2019-08-05 Modulating ptpn2 to increase immune responses and perturbing gene expression in hematopoietic stem cell lineages

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US201862715605P 2018-08-07 2018-08-07
US62/715,605 2018-08-07
US201962805557P 2019-02-14 2019-02-14
US62/805,557 2019-02-14

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EP3664830A4 (en) 2017-08-07 2020-07-01 The Regents of the University of California Platform for generating safe cell therapeutics
US20220081691A1 (en) * 2018-08-07 2022-03-17 Dana-Farber Cancer Institute, Inc Modulating ptpn2 to increase immune responses and perturbing gene expression in hematopoietic stem cell lineages
CN112080527A (en) * 2020-09-16 2020-12-15 南京市第一医院 Recombinant expression vector, chimeric antigen receptor T cell with reduced exhaustion and application thereof

Citations (3)

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Publication number Priority date Publication date Assignee Title
US20050074878A1 (en) * 2001-05-18 2005-04-07 Cowsert Lex M. Antisense modulation of ptpn2 expression
WO2015188228A1 (en) * 2014-06-10 2015-12-17 Monash University Method of producing leukocytes using ptpn2 inhibition for adoptive cell transfer
WO2020072126A2 (en) * 2018-08-07 2020-04-09 Dana-Farber Cancer Institute, Inc. Modulating ptpn2 to increase immune responses and perturbing gene expression in hematopoietic stem cell lineages

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WO2000036111A1 (en) * 1998-12-11 2000-06-22 Mcgill University Therapeutic and diagnostic uses of protein tyrosine phosphatase tc-ptp

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
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