WO2020048097A1 - 一种吸液指示部件和液体检测装置 - Google Patents

一种吸液指示部件和液体检测装置 Download PDF

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Publication number
WO2020048097A1
WO2020048097A1 PCT/CN2019/076601 CN2019076601W WO2020048097A1 WO 2020048097 A1 WO2020048097 A1 WO 2020048097A1 CN 2019076601 W CN2019076601 W CN 2019076601W WO 2020048097 A1 WO2020048097 A1 WO 2020048097A1
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Prior art keywords
liquid
core
detection device
indicating member
guiding core
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PCT/CN2019/076601
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English (en)
French (fr)
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王立平
周兴夫
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王水娟
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Publication of WO2020048097A1 publication Critical patent/WO2020048097A1/zh

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09F—DISPLAYING; ADVERTISING; SIGNS; LABELS OR NAME-PLATES; SEALS
    • G09F3/00—Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps
    • G09F3/02—Forms or constructions
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09F—DISPLAYING; ADVERTISING; SIGNS; LABELS OR NAME-PLATES; SEALS
    • G09F3/00—Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps
    • G09F3/02—Forms or constructions
    • G09F3/03—Forms or constructions of security seals

Definitions

  • the invention relates to a liquid-absorptive indicating member and a liquid detection device using the liquid-absorptive indicating member, in particular to the application of the liquid-absorptive indicating member in the field of medical testing and drug detection for determining the presence of at least one analyte in a liquid. Detection device.
  • the in vitro diagnostic device should be simple and easy to use.
  • the user usually only needs to apply liquid to the sample collection site of the detection device, and observe the test result after a few minutes.
  • the fluid tested is usually urine, saliva, blood or fluid collected from other parts of the body.
  • One of the methods to solve the above problems is to use a color change indicator.
  • the principle is to use the characteristics of color changes when chemical substances such as dyes encounter aqueous solutions.
  • a dye or pH indicator is added to the liquid-absorptive indicator made of fiber bonding.
  • the liquid-absorptive indicator is The dye or pH indicator changes color depending on the nature of the liquid.
  • the disadvantage of this method is that the dye or pH indicator may interfere with the specific reaction and affect the detection results. And the pH value of the liquid collected from different human bodies has individual differences, which may cause the color change of the indicator to be unstable.
  • this method also needs to add a cross-linkable substance to perform a chemical reaction to fix the discoloration indicator in the liquid-absorptive indicator member to prevent the indicator from moving during the use of the detection device.
  • the cross-linking reaction not only complicates manufacture and increases cost, but also blocks the capillary channels in the liquid-absorptive indicating member, reducing the liquid conduction speed.
  • Another method is to make a colored liquid-absorptive indicator part with fiber bonding, and then cover or impregnate a layer of substance on the liquid-absorptive indicator part in whole or in part. Its role is to shield the color of the liquid-absorptive indicator part in a dry state. However, it does not have the ability of the liquid-absorptive indicating member to conduct liquid quickly. Such a coating or covering has low transparency when dry but has high transparency after wetting, so that the color of the liquid-absorbing indicating member can be observed from the outside after wetting.
  • Chinese Patent Publication No. CN1615441A mentions the use of sugar paste, glucose paste, nitrocellulose membrane, nylon microporous membrane and filter paper.
  • the disadvantage of this technology is that when the liquid-absorption indicator is impregnated with sugar paste or glucose paste, the capillary channels in the liquid-absorption indicator are blocked in a large amount, which seriously reduces the speed at which the liquid-absorption indicator conducts the measured liquid, which significantly affects the detection. speed.
  • the nylon microporous filter membrane or filter paper also has a very slow liquid-conducting speed, and because the covered nylon microporous filter membrane or filter paper is easily detached from the liquid absorption indicator, the effect is poor in practical applications.
  • U.S. Patent No. 9,330,580 and B2 discloses another color-changing indication scheme for the liquid-absorption indicating member.
  • a completely liquid-impermeable colored core is wholly or partially covered in a liquid-absorbent indicator member made of fiber bonding.
  • the transparency of the liquid-absorbent indicator member is improved. Thereby, the color of the colored core can be observed.
  • the significant disadvantage of this technique is that the colored core that does not absorb liquid at all does not have the function of conducting liquid, and it occupies a part of the volume of the liquid absorption indicating member, so that the liquid absorption amount of the liquid absorption indicating member is reduced, and in the diagnostic device, The amount of liquid absorbed by the liquid aspiration indicator is a very important technical indicator. Decreasing the amount of liquid usually reduces the detection sensitivity.
  • the liquid-absorption indicating member must not only meet the significant change in transparency before and after water absorption, but also meet the requirement of rapidly transmitting the liquid to the reaction zone, which has a large limitation in performance.
  • the liquid-absorptive indicator when the liquid-absorptive indicator is made of filaments, the liquid-absorptive indicator has a poor ability to shield the colored core in a dry state, and when the liquid-absorptive indicator is made of staple fibers, Liquid conduction is slow.
  • the present invention discloses a liquid-absorptive indicating member, which includes: a first liquid-conducting core; and a second liquid-conducting core, and an identification portion is provided on an outer peripheral surface of the second liquid-conducting core.
  • the first liquid guiding core completely or partially covers the identification part of the second liquid guiding core, and the transparency of the first liquid guiding core increases as the amount of collected liquid increases.
  • the first liquid-conducting core is made of two-component fibers bonded with a sheath-core structure.
  • the sheath of the bicomponent fiber contains at least one of polyethylene, polypropylene, or polyolefin.
  • the first liquid-conducting core is made of filaments or staple fibers.
  • the material thickness of the first liquid-conducting core is 0.5-2 mm.
  • the second liquid-conducting core is made of two-component fibers bonded with a sheath-core structure.
  • the identification portion is a color, a pattern, or a character.
  • the second liquid-conducting core is made of a bicomponent filament.
  • the invention also discloses a liquid detection device.
  • the liquid detection device includes the above-mentioned liquid absorption indicating member.
  • the liquid detection device further comprises: a casing, a porous carrier accommodated in the casing; the porous carrier is directly or indirectly connected to the liquid absorption indicating member, wherein the porous carrier has a detection region, and the casing is provided at a position corresponding to the detection region. There are observation windows.
  • the liquid detection device further includes a labeled analyte-specific binding reagent that moves freely in a porous carrier in a wet state, and a reagent for the same analyte that is permanently fixed in the detection region of the porous carrier and cannot be moved in a wet state.
  • the relative position of the unlabeled specific binding reagent, the labeled reagent and the detection zone is such that the liquid added to the liquid detection device carries the labeled reagent and penetrates into the detection zone.
  • the porous carrier is connected to the first liquid-guiding core, or the second liquid-guiding core, or the porous carrier is connected to the first liquid-guiding core and the second liquid-guiding core at the same time.
  • the user can be instructed to accurately use the liquid detection device when collecting liquid, and it has both a fast liquid conduction speed and a large liquid absorption amount. Therefore, the liquid detection device according to the present invention Fast detection speed and high sensitivity.
  • FIG. 1a is a schematic structural diagram of a liquid detection device according to a first embodiment of the present invention before liquid collection;
  • FIG. 1b is a schematic structural diagram of a liquid detection device according to a first embodiment of the present invention after liquid collection;
  • 1c is a schematic structural view of a cross-sectional area when the liquid-absorptive indicating member according to the present invention is a cylinder;
  • FIG. 1d is a structural schematic diagram of a cross-sectional area when the liquid-absorptive indicating member according to the present invention is a square cylinder;
  • FIG. 2a is a schematic structural diagram of a liquid detection device according to a second embodiment of the present invention before liquid collection;
  • FIG. 2b is a schematic structural diagram of a liquid detection device according to a second embodiment of the present invention after liquid collection;
  • FIG. 3a is a schematic structural diagram of a liquid detection device according to a third embodiment of the present invention before liquid collection;
  • FIG. 3b is a schematic structural diagram of a liquid detection device according to a third embodiment of the present invention after liquid collection;
  • FIG. 4a is a schematic structural diagram of a liquid detection device according to a fourth embodiment of the present invention before liquid collection;
  • FIG. 4b is a schematic structural diagram of a liquid detection device according to a fourth embodiment of the present invention after liquid collection.
  • FIG. 1a is a schematic structural diagram of a liquid detection device according to a first embodiment of the present invention before liquid collection
  • FIG. 1b is a schematic structural diagram of a liquid detection device according to a first embodiment of the present invention after liquid collection.
  • the liquid detection device 1 includes a liquid absorption indicating member 3.
  • the liquid-absorption indicating member 3 includes a first liquid-guiding core 31; and a second liquid-guiding liquid 32, and a marking portion is provided on an outer peripheral surface of the second liquid-guiding liquid 32, and the first liquid-guiding core 31 completely or partially covers the second In the identification portion of the liquid guiding core 32, the transparency of the first liquid guiding core 31 increases as the amount of collected liquid increases.
  • the first liquid guiding core 31 Prior to the liquid collection, the first liquid guiding core 31 has low transparency or is in an opaque state, and the identification part of the second liquid guiding core 32 is shielded. The identification of the second liquid guiding core 32 cannot be observed through the first liquid guiding core 31. After the first liquid guiding core 31 starts to absorb liquid, the transparency of the first liquid guiding core 31 increases as the amount of collected liquid increases. When the first liquid guiding core 31 is completely wetted by the liquid, the first liquid guiding core 31 In the almost transparent state, the marking portion of the second liquid guiding core 32 can be clearly observed through the wetted first liquid guiding core 31.
  • the liquid-absorbent member may be treated with a surfactant (such as Triton-100, Tween-20, etc.) to increase the hydrophilicity of the liquid-absorbent member. Sex.
  • a surfactant such as Triton-100, Tween-20, etc.
  • FIG. 1c is a schematic cross-sectional structure diagram when the liquid-absorptive indicating member according to the present invention is a cylinder.
  • the second liquid-conducting core 32 is a cylinder, and the entire liquid-absorption indicating member 3 is also a cylinder;
  • the first liquid-conducting core 31 covers the outer periphery of the second liquid-conducting core 32, and
  • the cross section of 1 is such that the circumference of the second liquid-conducting core 32 is covered by the first liquid-conducting core 31.
  • FIG. 1d is a schematic structural diagram of a cross section when the liquid-absorption indicating member according to the present invention is a square cylinder.
  • the second liquid-conducting core 32 is a square cylinder, and the entire liquid-absorption indication member 3 is also a square-cylinder; the first liquid-conducting core 31 is wrapped around the second liquid-conducting core 32, On the cross section of the indicating member 1, the periphery of the second liquid guiding core 32 is covered by the first liquid guiding core 31.
  • Figures 1c and 1d are merely examples of the shape of the liquid-absorptive indicator member 3.
  • the cross-section is a polygon or the like, which does not depart from the purpose of the present invention.
  • Simple deformations belong to equivalent implementations covered by the protection scope of the claims of the present invention.
  • the characteristic of the transparency improvement after the first liquid-wicking core 31 absorbs liquid makes the identification portion of the second liquid-wicking core 32 covered by the first liquid-wicking core 31 observable, which is convenient.
  • the user determines whether the liquid is accurately collected on the detection device, or it is convenient for the user to determine whether sufficient liquid has been collected.
  • the first liquid-conducting core 31 is made of two-component filaments or staple fibers bonded with a sheath-core structure.
  • the sheath of the bicomponent fiber is at least one of polyethylene, polypropylene, or polyolefin.
  • the core layer in the bicomponent fiber may be polyethylene, polypropylene, polyester, nylon, or the like.
  • the first liquid-conducting core 31 has a faster liquid conduction speed, which is beneficial to shorten the detection time.
  • the bicomponent fibers are staple fibers, because the staple fibers are randomly stacked in the first liquid-guiding core 31, the first liquid-guiding core 31 can better cover the identification of the second liquid-guiding core 32 with the same thickness. So as to increase the contrast of the sharpness of the marking portion before and after the first liquid guiding core 31 is infiltrated.
  • the porosity of the first liquid guiding core 31 is generally set to 65-85%.
  • the material thickness of the first liquid guiding core 31 covering the second liquid guiding core 32 is 0.5-2 mm, such as 0.5 mm, 0.8 mm, 1 mm, 1.2 mm, 1.5 mm, and 2 mm. It is preferably 0.8-1.2 mm.
  • the material thickness of the first liquid-conducting core 31 is less than 0.5 mm, the shielding ability of the first liquid-conducting core 31 to the identification portion is insufficient, and it is easy to observe the identification portion of the second liquid-conducting core 32 before the liquid collection, and the liquid-absorption indicating member The sharpness of the sign before and after the infiltration did not change significantly.
  • the material thickness of the first liquid-conducting core 31 is greater than 2 mm, the transparency of the first liquid-conducting core 31 is insufficient after wetting, and it is difficult to observe the identification portion of the second liquid-conducting core 32 after the liquid-absorbing indicator member is wetted.
  • the material thickness of the first liquid-conducting core 31 is 0.8-1.2 mm, the first liquid-conducting core 31 has a good shielding ability to the marking portion when it is dry, and has good transparency in the case of wetting.
  • the commonly used total thickness of the liquid-absorbing indicator member having a rectangular cross-section is 2.8-5 mm, because the total material thickness of the first liquid guiding core 31 is two times the material thickness of the first liquid guiding core 31 that shields the second liquid guiding core 32. Times, that is, the optimal total material thickness of the first liquid guiding core 31 is 1.6-2.4 mm, and the remaining thickness is left to the second liquid guiding core 32.
  • This structure makes the liquid absorbing indicator component easy to manufacture.
  • the second liquid-conducting core 32 is made of two-component fibers bonded with a sheath-core structure, such as polyethylene / polypropylene fibers, polyethylene / polyester fibers, copolyester / polyester fibers, nylon / polyester fibers, and the like.
  • the identification portion of the second liquid-conducting core 32 may be a color, a pattern, or a text formed on a peripheral surface of the second liquid-conducting core 32.
  • the second liquid-conducting core 32 can be made by bonding colored fibers or coloring the colorless fibers, thereby forming a color-marking portion on the outer peripheral surface of the second liquid-conducting core 32.
  • the colorant should be solid, not dissolved by the liquid, and does not interfere with the detection of the analyte by the detection device. Pigments are preferred. It is also possible to select a dye that has a strong coloring force on the second liquid guiding core 32 and does not interfere with the detection.
  • the color of the second liquid-conducting core 32 may be brighter colors such as sapphire blue, green, rose red, pink, and orange red.
  • the bright color forming the marking portion helps to improve the contrast of the sharpness change of the marking portion when the first liquid guiding core 31 is infiltrated. Different colors can be selected according to user preferences.
  • a pattern or a character may be provided on the outer peripheral surface of the second liquid-conducting core 32 as the identification portion.
  • the identification portion may be formed on the outer peripheral surface of the second liquid guiding core 32 by a combination of colors, patterns, or characters.
  • the second liquid-conducting core 32 may be made of filaments or staple fibers, but filaments are preferred. Since the filaments are generally parallel in the second liquid-conducting core 32 and coincide with the direction of liquid conduction, the second liquid-conducting core 32 made of the filaments conducts liquid quickly, which is beneficial to shortening the detection time.
  • the second liquid guiding core 32 of the liquid absorption indicating member is made of filaments
  • the first liquid guiding core 31 is made of staple fiber
  • the liquid absorption indicating member 3 as a whole has a fast liquid conduction speed, and at the same time Significant changes in the sharpness of the marking section during liquid collection.
  • the liquid detection device 1 includes: a casing 2, a porous carrier 4 accommodated in the casing 2; the porous carrier 4 is directly or indirectly connected to the above-mentioned liquid-absorption indicating member 3, wherein the porous carrier 4 has a detection Area 41, and the casing 2 is provided with an observation window 21 at a position corresponding to the detection area 41.
  • One end of the liquid-absorptive indicating member 3 may extend into the casing 2 and be fixed by the casing 2, and is connected to the porous carrier 4, and the other end of the liquid-absorbent indicating member 3 protrudes outside the casing 2.
  • the liquid detection device 1 further includes a labeled analyte-specific binding reagent that moves freely in a porous carrier in a wet state, and a reagent for the same analyte that is permanently fixed in the detection region 41 of the porous carrier 4 and cannot be moved in a wet state.
  • the relative positions of the unlabeled specific binding reagent, the labeled reagent and the detection area 41 enable the liquid added to the liquid detection device 1 to carry the labeled reagent and penetrate into the detection area 41.
  • the porous carrier 4 may be connected to the first liquid guiding core 31, or the second liquid guiding core 32, or the porous carrier 4 may be connected to the first liquid guiding core 31 and the second liquid guiding core 32 at the same time, or through, for example, a catheter or a liquid guiding core.
  • the liquid guiding member is connected to the liquid suction indicating member 3.
  • the second liquid guiding core 32 is preferably a cylinder or a square cylinder, and the entire liquid absorption indicating member 3 is also a cylinder or a square cylinder. Both ends of the second liquid-conducting core 32 do not exceed the first liquid-conducting core 31.
  • the first liquid-conducting core 31 is preferably provided with a cavity portion 33 having a columnar shape or a square columnar shape at both ends.
  • the cavity portion 33 extends from an end surface of the first liquid-conducting core 31 to an end surface of the second liquid-conducting core 32. Therefore, the length of the second liquid-conducting core 32 is shorter than that of the first liquid-conducting core 31, so that the second liquid-conducting core 32 is entirely covered by the first liquid-conducting core 31.
  • the first liquid-conducting core 31 may be provided with a cavity portion 33 having a columnar shape or a square columnar shape at only one end.
  • the porous carrier 4 in the liquid detection device 1 is correspondingly arranged in a cylindrical shape or a square column shape. After the liquid-absorption indicating member 3 and the casing 2 are assembled, the porous carrier 4 can be inserted into the cavity portion 33 of the first liquid-guiding core 31 so as to be connected to the first liquid-guiding core 31 and the second liquid-guiding core 32 at the same time. The liquid-conducting speed between the liquid-absorption indicating member 3 and the porous carrier 4 is increased, and the detection sensitivity of the liquid detection device 1 is improved.
  • the liquid absorption indicating member 3 when the liquid absorption indicating member 3 is a cylinder, preferably, the outer diameter of the first liquid guiding core 31 is 4.2 mm, the inner diameter is 2 mm, the diameter of the second liquid guiding core 32 is 2 mm, and the liquid detection device
  • the porous carrier 4 in 1 has a diameter of 2 mm, and the liquid absorption indicating member 3 is suitable for a cylindrical liquid detection device 1.
  • the thickness of the second liquid-conducting core is preferably 1mm-3mm, and the thickness of the single-sided material covering the first liquid-conducting core is 0.8mm-1.2mm.
  • the total thickness of the liquid indicating member 3 is 3mm-4.5mm.
  • the liquid absorbing indicating member 3 is suitable for a liquid detection device 1 similar to a square cylinder.
  • the second liquid-guiding core 32 is preferably made by bonding colored fibers, so the identification portion of the second liquid-guiding core 32 is a color formed on the peripheral surface.
  • the liquid quickly wets the first liquid-guiding core 31 (generally, about 2 seconds).
  • the first liquid guiding core 31 in the liquid suction indicating member 3 absorbs enough liquid
  • the first liquid guiding core 31 in the liquid suction indicating member 3 becomes transparent, and the user can pass through the first
  • the color of the peripheral surface of the second liquid-conducting core 32 is observed by the liquid-conducting core 31, and accordingly, it is convenient for the user to determine whether the liquid is accurately applied to the liquid detection device 1.
  • the liquid absorbed by the first liquid guiding core 31 diffuses to the second liquid guiding core 32, and the liquid is conducted to the porous carrier 4 by the first liquid guiding core 31 and the second liquid guiding core 32 together, and the liquid is on the porous carrier 4.
  • the liquid detection device 1 can facilitate the user to determine whether the liquid is accurately applied to the liquid detection device 1 through the liquid absorption indicating member 3, and at the same time, the first liquid guiding core 31 and the second liquid guiding core constituting the liquid suction indicating member 3 Both 32 have liquid absorption and liquid guiding functions, so that the liquid absorption indicating member 3 has a large liquid absorption and a fast liquid guiding speed, and can quickly conduct the liquid to the porous carrier 4, thereby improving the liquid absorption efficiency of the liquid detection device 1.
  • the end of the liquid absorption indicating member 3 exposed on the outer side of the casing may be immersed in the liquid, and the first liquid guiding core 31 and the second liquid guiding core 32 will be wetted at the same time. After the first liquid guiding core 31 absorbs enough liquid, the first liquid guiding core 31 becomes transparent. Through the first liquid guiding core 31, the user can immediately observe the color of the peripheral surface of the second liquid guiding core 32. This process is generally It is about 2 seconds, and accordingly, it is convenient for the user to determine whether the liquid is accurately applied to the detection device 1.
  • the liquid detected by the detection device 1 may be urine, and the analyte is human chorionic gonadotropin (hCG), luteinizing hormone (LH), or an abused drug.
  • the liquid to be detected can also be saliva, serum, and the like.
  • the liquid detection device 1 may be part of various in vitro diagnostic devices, such devices can determine whether a woman is pregnant by detecting whether human chorionic gonadotropin (hCG) is contained in urine, or by detecting whether urine contains luteinizing hormone Generates hormones (LH) to determine if a woman is about to ovulate, or it can be used to detect whether urine contains drugs such as cannabinoids, cocaine, amphetamines, and more. According to different analytes, different analyte-specific binding reagents are used in the liquid detection device 1. If the presence of more than one analyte in the liquid is to be detected simultaneously, the liquid detection device 1 needs to use more than one analyte-specific binding reagent, and each binding reagent is specific to each analyte to be detected.
  • hCG human chorionic gonadotropin
  • LH Generates hormones
  • the liquid detection device can instruct the user to accurately use the liquid detection device when collecting liquid, and it has both a fast liquid conduction speed and a large liquid absorption amount. Therefore, according to the first embodiment of the present invention, The liquid detection device has fast detection speed and high sensitivity.
  • FIG. 2a is a schematic structural diagram of a liquid detection device according to a second embodiment of the present invention before liquid collection
  • FIG. 2b is a schematic structural diagram of a liquid detection device according to a second embodiment of the present invention after liquid collection.
  • this embodiment is similar to the first embodiment, except that the outer peripheral surface of the second liquid guiding core 32 is covered by the first liquid guiding core 31, and the two end surfaces of the second liquid guiding core 32 and The two ends of the first liquid-conducting core 31 are flush, so the length of the second liquid-conducting core 32 is equal to the length of the first liquid-conducting core 31.
  • the porous carrier 4 is connected to the first liquid guiding core 31.
  • the porosity of the second liquid-conducting core in this embodiment is 65-80%, and is made of nylon / polyester filaments with a sheath-core structure.
  • the first liquid-conducting core 31 has a porosity of 65-85% and is made of polyethylene / polyester staple fiber with a sheath-core structure.
  • the second liquid-conducting core 32 made of nylon / polyester filaments with a sheath-core structure has a particularly fast liquid-conducting speed.
  • the first liquid-conducting core 31 is not wet, it has good shielding performance and can quickly absorb liquid from the second liquid-conducting core 32 and improve transparency, so that the user can quickly see the identification portion of the second liquid-conducting core 32.
  • These characteristics of the first liquid guiding core 31 and the second liquid guiding core 32 can significantly improve the detection speed and detection sensitivity of the liquid detection device, and improve the user experience.
  • this structure can simplify the production process of the liquid-absorptive indicating member 3, improve production efficiency, and reduce costs.
  • FIG. 3a is a schematic structural diagram of a liquid detection device according to a third embodiment of the present invention before liquid collection
  • FIG. 3b is a schematic structural diagram of a liquid detection device according to a third embodiment of the present invention after liquid collection.
  • this embodiment is similar to the first embodiment, except that one end surface of the second liquid-conducting core 32 protrudes from the first liquid-conducting core 31, and detects the liquid-absorption indicating member 3 and the liquid.
  • the end of the second liquid guiding core 32 protruding from the end surface of the first liquid guiding core 31 is connected to the porous carrier 4 in the liquid detection device 1.
  • the first liquid guiding core 31 and the second liquid guiding core 32 are made of bicomponent fibers with the same diameter and the skin layers are polyethylene.
  • the thickness of the second liquid guiding core 32 is 1 mm, and the first liquid guiding core 31 covers the first
  • the material thickness of the two-lead liquid core 32 on one side is 1 mm.
  • the porosity of the first liquid-conducting core 31 is 70-85%, the porosity of the second liquid-conducting core 32 is 60-80%, and the porosity of the first liquid-conducting core 31 is greater than that of the second liquid-conducting core 32, Therefore, the capillary force of the second liquid-conducting core 32 is greater than that of the first liquid-conducting core 31.
  • the liquid absorption indicating member of this structure not only has a fast liquid conduction speed and a marked change in the marking portion, but also due to the difference in capillary force, when the second liquid-conducting core 32 conducts liquid to the porous carrier 4, it can be more quickly from the first Liquid is absorbed in a liquid-conducting core 31, which is beneficial to improve detection speed and sensitivity.
  • FIG. 4a is a schematic structural diagram of a liquid detection device according to a fourth embodiment of the present invention before liquid collection
  • FIG. 4b is a schematic structural diagram of a liquid detection device according to a fourth embodiment of the present invention after liquid collection.
  • this embodiment is similar to the first embodiment, except that the first liquid guiding core 31 covers the outer peripheral surface of the second liquid guiding core 32, and both end surfaces of the second liquid guiding core 32 are Located on the inner sides of the two sides of the first liquid guiding core 31, so the length of the second liquid guiding core 32 is shorter than the length of the first liquid guiding core 31, so that the second liquid guiding core 32 is completely covered by the first liquid guiding core 31,
  • the liquid-absorption instruction member 3 is assembled with the casing 2 of the liquid detection device 1, it is connected from the first liquid guiding core 31 to the porous carrier 4 in the liquid detection device 1.
  • This structure prevents the user from observing the colors of the two ends of the second liquid guiding core 32, and when the liquid absorption of the first liquid guiding core 31 becomes transparent, it is convenient for the user to effectively observe the logo of the second liquid guiding core 32 unit.
  • the liquid detection device can observe the change in the sharpness of the marking portion when collecting a sample, thereby instructing the user to use the liquid detection device correctly, and has both a fast liquid conduction speed and a large liquid absorption capacity. Fast detection speed and high sensitivity.
  • the above embodiments of the present invention merely illustrate the principle of the present invention and its effects, but are not intended to limit the present invention. Any person skilled in the art can modify or change the above embodiments without departing from the spirit and scope of the present invention. Therefore, all equivalent modifications or changes made by those skilled in the art without departing from the spirit and technical ideas disclosed by the present invention should still be covered by the claims of the present invention.

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Abstract

本申请公开了一种用于确定液体中至少一种分析物存在的液体检测装置，所述液体检测装置包括吸液指示部件和多孔载体，当与液体接触时所述吸液指示部件吸取液体并将液体传导给所述多孔载体，待测分析物在所述多孔载体的检测区中与试剂反应，所述吸液指示部件被液体润湿时标识部立即被显现。

Description

一种吸液指示部件和液体检测装置 技术领域
本发明涉及一种吸液指示部件和一种应用该吸液指示部件的液体检测装置，特别涉及医学检验和毒品检测领域中用于确定液体中至少一种分析物存在的应用该吸液指示部件的检测装置。
背景技术
在家庭、诊所和医院等场所，快速的体外诊断已经被广泛应用，如验孕、排卵、毒品滥用、传染疾病等。一般情况下，特别是家庭中使用时，体外诊断装置应该简单易用，使用者通常只需施加液体到检测装置的样品采集部位，数分钟后观察检测结果即可。被检测的液体通常为尿液、唾液、血液或从身体其它部位采集的液体。这些样品中除血液外大部分为无色或非常浅色的液体，这带来一个问题，即使用者较难判断是否正确地施加了液体到检测装置上。
解决上述问题的其中一种方法是采用变色指示剂，其原理是用染料等化学物质遇到水溶液时发生颜色变化的特点。如公开号为CN1615441A的中国专利提到，在用纤维粘结制成的吸液指示部件上添加染料或pH指示剂，当液体施加到采集样品的吸液指示部件上时，吸液指示部件上的染料或pH指示剂根据液体的性质改变颜色。这种方法的缺点在于染料或pH指示剂可能会干扰特异反应从而影响检测结果。并且从不同人体上采集的液体的pH值存在个体差异，可能导致指示剂的颜色变化不稳定。另外，这种方法还需要加入可交联的物质进行化学反应将变色指示剂固定在吸液指示部件中以免指示剂在检测装置使用过程中发生移动。交联反应不仅使制造变得复杂，成本提高，交联还会堵塞吸液指示部件中的毛细通道，降低液体传导速度。
另一种方法是用纤维粘结制成有色的吸液指示部件，然后在吸液指示部件上全部或部分覆盖或浸渍一层物质，其作用是在干燥状态下遮蔽吸液指示部件的颜色，但其并不具备吸液指示部件快速传导液体的能力，这种涂层或覆盖物干燥时透明度较低但浸润后透明度较高，从而在浸润后可以从外界观察到吸液指示部件的颜色。如公开号为CN1615441A的中国专利提到采用糖糊剂、葡萄糖糊剂、硝酸纤维素膜、尼龙微孔膜和滤纸。这种技术的缺陷是当吸 液指示部件被糖糊剂或葡萄糖糊剂浸渍后，吸液指示部件中的毛细通道被大量堵塞，严重降低吸液指示部件传导被测液体的速度，显著影响检测速度。尼龙微孔滤膜或滤纸的导液速度也非常慢，并且由于覆盖的尼龙微孔滤膜或滤纸与吸液指示部件容易脱开，实际应用中效果较差。
专利号为US 9,330,580 B2的美国专利公开了吸液指示部件的另一种变色指示方案。该方案中一个完全不导液的有色芯体被全部或部分包覆在用纤维粘结制成的吸液指示部件中，当液体施加到吸液指示部件上时，吸液指示部件的透明度提高从而可以观察到有色芯体的颜色。然后这种技术的显著缺点是完全不吸液的有色芯体不具有传导液体的功能，并且占据了吸液指示部件的部分体积，使吸液指示部件的吸液量减少，而在诊断装置中，吸液指示部件的吸液量是一个非常重要的技术指标，吸液量减少通常使检测的灵敏度降低。此外，由于有色芯体完全不具有传导液体的功能，吸液指示部件既要满足吸水前后透明度发生显著变化，又要满足将液体快速地传导至反应区，在性能上具有较大的局限性，比如，当吸液指示部件由长丝制成时，吸液指示部件在干燥状态下对有色芯体的遮蔽能力较差，而当吸液指示部件由短纤制成时，吸液指示部件的液体传导速度比较慢。
发明内容
为解决现有技术的缺点，本发明公开了一种吸液指示部件，吸液指示部件包括：第一导液芯；和第二导液芯，第二导液芯的外周表面上设置标识部，第一导液芯全部或部分包覆第二导液芯的标识部，第一导液芯的透明度随着采集液体量的增加而提高。
优选地，第一导液芯由皮芯结构的双组份纤维粘结制成。
优选地，双组份纤维的皮层含有聚乙烯、聚丙烯或聚烯烃中的至少一种。
优选地，第一导液芯由长丝或短纤制成。
优选地，第一导液芯的材料厚度为0.5-2mm。
优选地，第二导液芯由皮芯结构的双组份纤维粘结制成。
优选地，标识部为颜色、图案或者文字。
优选地，第二导液芯由双组份长丝制成。
本发明还公开了一种液体检测装置，液体检测装置包括上述的吸液指示部件。
优选地，液体检测装置还包括：外壳，容纳在外壳中的多孔载体；多孔载体直接或者间接与吸液指示部件连接，其中，多孔载体具有检测区，且外壳在与检测区对应的位置上设置有观察窗。
优选地，液体检测装置还包括在湿态下在多孔载体中自由移动的标记的分析物特异性结合试剂，以及永久固定在多孔载体的检测区且在湿态下不能移动的针对同一分析物的未标记特异性结合试剂，标记的试剂和检测区的相对位置使得加在液体检测装置上的液体携带标记的试剂并渗透进入所述检测区。
优选地，多孔载体连接第一导液芯、或第二导液芯，或多孔载体同时连接第一导液芯和第二导液芯。
根据本发明吸液指示部件和液体检测装置，能在采集液体时指示使用者准确使用液体检测装置，且其兼具快速的液体传导速度和较大吸液量，因此根据本发明的液体检测装置检测速度快、灵敏度高。
为让本发明的上述内容能更明显易懂，下文特举优选实施例，并结合附图，作详细说明如下。
附图说明
一个或多个实施例通过与之对应的附图中的图片进行示例性说明，这些示例性说明并不构成对实施例的限定，附图中具有相同参考数字标号的元件表示为类似的元件，除非有特别申明，附图中的图不构成比例限制。
图1a为液体采集前的根据本发明第一实施例的液体检测装置的结构示意图；
图1b为液体采集后的根据本发明第一实施例的液体检测装置的结构示意图；
图1c为根据本发明的吸液指示部件为圆柱体时的横截面积的结构示意图；
图1d为根据本发明的吸液指示部件为方柱体时的横截面积的结构示意图；
图2a为液体采集前的根据本发明第二实施例的液体检测装置的结构示意图；
图2b为液体采集后的根据本发明第二实施例的液体检测装置的结构示意图；
图3a为液体采集前的根据本发明第三实施例的液体检测装置的结构示意图；
图3b为液体采集后的根据本发明第三实施例的液体检测装置的结构示意图；
图4a为液体采集前的根据本发明第四实施例的液体检测装置的结构示意图；
图4b为液体采集后的根据本发明第四实施例的液体检测装置的结构示意图。
具体实施方式
以下由特定的具体实施例说明本发明的实施方式，本领域技术人员可由本说明书所揭示 的内容轻易地了解本发明的其他优点及功效。
现在参考附图介绍本发明的示例性实施方式，然而，本发明可以用许多不同的形式来实施，并且不局限于此处描述的实施例，提供这些实施例是为了详尽地且完全地公开本发明，并且向所属技术领域的技术人员充分传达本发明的范围。对于表示在附图中的示例性实施方式中的术语并不是对本发明的限定。在附图中，相同的单元/元件使用相同的附图标记。
除非另有说明，此处使用的术语包括科技术语对所属技术领域的技术人员具有通常的理解含义。另外，可以理解的是，以通常使用的词典限定的术语，应当被理解为与其相关领域的语境具有一致的含义，而不应该被理解为理想化的或过于正式的意义。
第一实施例
图1a为液体采集前的根据本发明第一实施例的液体检测装置的结构示意图；图1b为液体采集后的根据本发明第一实施例的液体检测装置的结构示意图。如图1a和1b所示，液体检测装置1包括吸液指示部件3。
<吸液指示部件>
吸液指示部件3包括第一导液芯31；和第二导液芯液体32，第二导液芯液体32的外周表面上设置标识部，第一导液芯31全部或部分包覆第二导液芯32的标识部，第一导液芯31的透明度随着采集液体量的增加而提高。
第一导液芯31在液体采集前，透明度低或处于不透明的状态，第二导液芯32的标识部被遮蔽，透过第一导液芯31无法观察到第二导液芯32的标识部；第一导液芯31开始吸收液体后，第一导液芯31的透明度随着采集液体量的增加而提高，当第一导液芯31被液体完全浸润时，第一导液芯31几乎处于透明的状态，透过浸润的第一导液芯31，可以清楚观察到第二导液芯32的标识部。
为增加吸液指示部件3的吸取和传导液体样品的能力，可以用表面活性剂(如曲拉通-100、吐温-20等)对吸液部件进行处理，以增加吸液部件的亲水性。
图1c为根据本发明的吸液指示部件为圆柱体时的横截面结构示意图。如图1c所示，第二导液芯32为圆柱体，吸液指示部件3整体也为圆柱体；第一导液芯31包覆在第二导液芯32的外周，在吸液指示部件1的横截面上，第二导液芯32的圆周被第一导液芯31包覆。
图1d为根据本发明的吸液指示部件为方柱体时的横截面的结构示意图。如图1d所示，第二导液芯32为方柱体，吸液指示部件3整体也为方柱体；第一导液芯31包覆在 第二导液芯32的四周，在吸液指示部件1的横截面上，第二导液芯32的四周被第一导液芯31包覆。
图1c和图1d仅仅是吸液指示部件3的形状的示例，本领域内的技术人员也可以很容易想到其它的变形方式，例如，横截面为多边形等方式，这种不背离本发明目的的简单变形均属于本发明权利要求保护范围所涵盖的等同实施方式。
根据本发明的吸液指示部件3，通过第一导液芯31吸液后透明度提高的特性，使得被第一导液芯31包覆的第二导液芯32的标识部被观察到，便于使用者判断液体是否被准确地采集到检测装置上，或者便于使用者判断是否采集到了足够的液体。
<第一导液芯>
第一导液芯31由皮芯结构的双组份长丝或短纤粘结制成。
双组份纤维的皮层为聚乙烯、聚丙烯或聚烯烃中的至少一种。
双组份纤维中的芯层可以为聚乙烯、聚丙烯、聚酯、尼龙等。当双组分纤维为长丝时，第一导液芯31具有较快的液体传导速度，有利于缩短检测时间。当双组分纤维为短纤时，由于短纤在第一导液芯31中随机堆叠，在相同厚度的情况下，第一导液芯31能够更好地遮蔽第二导液芯32的标识部，从而提高第一导液芯31浸润前后标识部清晰度变化的对比度。为使第一导液芯31适合于体外诊断装置的应用，通常设置第一导液芯31的孔隙率为65-85％。
覆盖第二导液芯32的第一导液芯31材料厚度为0.5-2mm，如0.5mm、0.8mm、1mm、1.2mm、1.5mm、2mm。优选为0.8-1.2mm。当第一导液芯31的材料厚度小于0.5mm时，第一导液芯31对标识部的遮蔽能力不足，容易在液体采集前观察到第二导液芯32的标识部，吸液指示部件浸润前后的标识部清晰度变化不显著。当第一导液芯31的材料厚度大于2mm时，浸润后第一导液芯31的透明度不足，吸液指示部件浸润后难以观察到第二导液芯32的标识部。当第一导液芯31的材料厚度为0.8-1.2mm时，第一导液芯31在干燥时对标识部具有良好的遮蔽能力，同时在浸润情况下具有良好的透明度。
此外，横截面为长方形的吸液指示部件的常用总厚度为2.8-5mm，由于第一导液芯31的材料总厚度为遮蔽第二导液芯32的第一导液芯31材料厚度的两倍，即第一导液芯31的最佳材料总厚度为1.6-2.4mm，剩余部分的厚度留给第二导液芯32，这种结构使吸液指示部件容易制造。
<第二导液芯>
第二导液芯32由皮芯结构的双组份纤维粘结制成，如聚乙烯/聚丙烯纤维，聚乙烯/聚酯 纤维，共聚酯/聚酯纤维，尼龙/聚酯纤维等。
第二导液芯32的标识部可以是第二导液芯32周表面上形成的颜色、图案或者文字。第二导液芯32可以用有色的纤维粘结制成或者将无色的纤维粘结后进行着色,从而在第二导液芯32的外周面上形成呈现颜色的标识部。着色剂应着色牢固不被液体溶解、并且不干扰检测装置对被分析物的检测，优选颜料。也可以选用对第二导液芯32着色力强并不干扰检测的染料。第二导液芯32的颜色可以为宝蓝色、绿色、玫红色、粉红色、橙红色等较为亮丽的颜色。亮丽的颜色形成标识部有助于提高在第一导液芯31浸润时标识部清晰度变化的对比度。不同的颜色选用可以根据使用者的喜好而定。
第二导液芯32的外周表面也可以设置图案或者文字来作为标识部。或者第二导液芯32的外周表面上由颜色、图案或者文字的组合来形成标识部。
第二导液芯32可以由长丝或短纤制成，但优选长丝。由于长丝在第二导液芯32中总体上呈平行状态并与液体传导方向一致，长丝制成的第二导液芯32传导液体速度快，有利于缩短检测时间。当吸液指示部件的第二导液芯32用长丝制成，并且第一导液芯31由短纤制成时，吸液指示部件3整体上既具有很快的液体传导速度，同时在液体采集过程中有显著的标识部清晰度变化。
<液体检测装置>
如图1a和1b所示，液体检测装置1包括：外壳2，容纳在外壳2中的多孔载体4；多孔载体4直接或者间接与上述的吸液指示部件3连接，其中，多孔载体4具有检测区41，且外壳2在与检测区41对应的位置上设置有观察窗21。
吸液指示部件3的一端可以伸入外壳2中被外壳2固定，并与多孔载体4相连接，吸液指示部件3的另一端伸出在外壳2之外。
液体检测装置1还包括在湿态下在多孔载体中自由移动的标记的分析物特异性结合试剂，以及永久固定在多孔载体4的检测区41且在湿态下不能移动的针对同一分析物的未标记特异性结合试剂，标记的试剂和检测区41的相对位置使得加在液体检测装置1上的液体携带标记的试剂并渗透进入检测区41。
多孔载体4可以连接第一导液芯31、或第二导液芯32，或多孔载体4同时连接第一导液芯31和第二导液芯32，或者通过诸如导液管或者导液芯的导液部件连接吸液指示部件3。
在本实施例中，如图1a-图1d所示，第二导液芯32优选为圆柱体或者方柱体，吸液指示部件3整体也为相应为圆柱体或者方柱体。第二导液芯32的两端不超过第一导液 芯31。
第一导液芯31优选两端设置呈圆柱状或者方柱状的空穴部33。空穴部33从第一导液芯31的端面延伸至第二导液芯32的端面处。故第二导液芯32的长度小于第一导液芯31的长度，使得第二导液芯32全部被第一导液芯31包覆。第一导液芯31也可以仅一端设置呈圆柱状或者方柱状的空穴部33。
液体检测装置1中的多孔载体4相应设置为圆柱状或者方柱状。将吸液指示部件3与外壳2装配后，多孔载体4可以插入第一导液芯31的空穴部33，从而与第一导液芯31和第二导液芯32同时连接，由此可以提高吸液指示部件3与多孔载体4之间的导液速度，并提高液体检测装置1的检测灵敏度。
在本实施例中，当吸液指示部件3为圆柱体时，优选，第一导液芯31的外径为4.2mm、内径为2mm，第二导液芯32的直径为2mm，液体检测装置1中的多孔载体4的直径为2mm，吸液指示部件3适用于圆柱形的液体检测装置1。
当吸液指示部件3为方柱体时，优选第二导液芯的厚度为1mm-3mm，第一导液芯包覆第一导液芯的单面材料厚度为0.8mm-1.2mm，吸液指示部件3的总厚度为3mm-4.5mm，吸液指示部件3适用于类似方柱形的液体检测装置1。
在本实施例中，第二导液芯32优选用有色的纤维粘结制成，故第二导液芯32的标识部为周表面上形成的颜色。
根据本发明的第一实施例，将液体施加到第一导液芯31的周表面后，液体迅速浸润第一导液芯31(一般2秒左右)。如图1b所示，当吸液指示部件3中的第一导液芯31吸收足够的液体后，吸液指示部件3中的第一导液芯31变透明，使用者便可以透过第一导液芯31观察到第二导液芯32周表面的颜色，据此，可便于使用者判断液体是否被准确地施加到液体检测装置1上。
与此同时，第一导液芯31吸收的液体扩散至第二导液芯32，液体被第一导液芯31和第二导液芯32一起传导至多孔载体4，液体在多孔载体4上渗透并将标记特异性试剂携带至检测区41；如果液体中含有被分析物，被分析物与标记特异性试剂结合并进一步与固定在检测区41的未标记特异性试剂结合，从而通过观察窗21观察到阳性的结果；如果液体中不含被分析物，则不发生上述结合反应，从而通过观察窗21观察到阴性的结果，使用者即可判断液体中是否存在有待分析物质。当然，也可以用与液体检测装置1配套的测量仪器来定量检测结合反应的程度。
上述液体检测装置1通过吸液指示部件3可便于使用者判断液体是否被准确地施加到液体检测装置1上，同时，构成吸液指示部件3的第一导液芯31和第二导液芯32都 具有吸液、导液功能，使得吸液指示部件3吸液量大、导液速度快，能够快速地将液体传导给多孔载体4，进而提高液体检测装置1的吸液效率。
上述液体检测装置1在使用时，也可将吸液指示部件3裸露在壳体外部的一端浸入到液体中，则第一导液芯31和第二导液芯32同时会被润湿，当第一导液芯31吸收足够的液体后，第一导液芯31变透明，透过第一导液芯31，使用者立即可以观察到第二导液芯32周表面的颜色，此过程一般为2秒左右，据此，可便于使用者判断液体是否被准确地施加到检测装置1上。
检测装置1检测的液体可以为尿液，被分析物为人绒毛膜促性腺激素(hCG)、促黄体生成激素(LH)或滥用的药物。当然，被检测的液体还可以为唾液、血清等。
液体检测装置1可以是各种体外诊断装置的一部分，这类装置可以通过检测尿液中是否含有人绒毛膜促性腺激素(hCG)来确定女性是否怀孕，或者通过检测尿液中是否含有促黄体生成激素(LH)来确定女性是否即将排卵，或者可以用来检测尿液中是否含有毒品，如大麻碱、可卡因、安非他命等。根据不同的被分析物，液体检测装置1中使用不同的分析物特异性结合试剂。如果要同时检测液体中一种以上的被分析物的存在，则液体检测装置1中需要使用一种以上的分析物特异性结合试剂，并且每种结合试剂对各个待测分析物是特异的。
根据本发明第一实施例的液体检测装置，能在采集液体时指示使用者准确使用液体检测装置，且其兼具快速的液体传导速度和较大吸液量，因此根据本发明第一实施例液体检测装置检测速度快、灵敏度高。
第二实施例
图2a为液体采集前的根据本发明第二实施例的液体检测装置的结构示意图；图2b为液体采集后的根据本发明第二实施例的液体检测装置的结构示意图。
如图2a和2b所示，本实施例与第一实施例相似，不同在于，第二导液芯32的外周表面被第一导液芯31包覆，第二导液芯32的两端面与的第一导液芯31两端面齐平，故第二导液芯32的长度与第一导液芯31的长度相等。将吸液指示部件3与液体检测装置1的外壳2装配后，多孔载体4连接第一导液芯31。本实施例中第二导液芯的孔隙率为65-80％，由皮芯结构的尼龙/聚酯长丝制成。第一导液芯31的孔隙率为65-85％，由皮芯结构的聚乙烯/聚酯短纤制成。由皮芯结构的尼龙/聚酯长丝制成第二导液芯32导液速度特别快。第一导液芯31未润湿时遮蔽性能好并能从第二导液芯32快速吸收液体、提高透明度、从而快速地让使用者看到第二导液芯32的标识部。第一导液芯31和第二导液芯32的这些特点可以显著提高液体检 测装置的检测速度和检测灵敏度，提高使用者体验。此外这种结构可以简化吸液指示部件3的生产工艺，提高生产效率，降低成本。
第三实施例
图3a为液体采集前的根据本发明第三实施例的液体检测装置的结构示意图；图3b为液体采集后的根据本发明第三实施例的液体检测装置的结构示意图。
如图3a和3b所示，本实施例与第一实施例相似，不同在于，第二导液芯32的一端面从第一导液芯31中伸出，将吸液指示部件3与液体检测装置1的外壳2装配后，从第一导液芯31的端面伸出的第二导液芯32的端部与液体检测装置1中的多孔载体4相连接。第一导液芯31和第二导液芯32由直径相同的双组分纤维制成，并且皮层均为聚乙烯，第二导液芯32的厚度为1mm，第一导液芯31覆盖第二导液芯32的材料单面厚度为1mm。第一导液芯31孔隙率为70-85％，第二导液芯32的孔隙率为60-80％，并且第一导液芯31的孔隙率大于第二导液芯32的孔隙率，因此第二导液芯32的毛细力大于第一导液芯31。这种结构的吸液指示部件不但液体传导速度快、标识部变化显著，并且由于毛细力的差异，当第二导液芯32将液体传导给多孔载体4时，可以更快更多地从第一导液芯31中吸收液体，有利于提高检测速度和灵敏度。
第四实施例
图4a为液体采集前的根据本发明第四实施例的液体检测装置的结构示意图；图4b为液体采集后的根据本发明第四实施例的液体检测装置的结构示意图。
如图4a和4b所示，本实施例与第一实施例相似，不同在于，第一导液芯31包覆在第二导液芯32的外周表面，第二导液芯32的两端面都位于第一导液芯31两端面的内侧，故第二导液芯32的长度小于第一导液芯31的长度，使得第二导液芯32全部被第一导液芯31包覆，将吸液指示部件3与液体检测装置1的外壳2装配后，从第一导液芯31与液体检测装置1中的多孔载体4相连接。这种结构使得使用者观察不到第二导液芯32两端面的颜色，在第一导液芯31吸液变透明时，能够便于使用者在有效地观察到第二导液芯32的标识部。
综上，本发明涉及的液体检测装置，能在采集样品时观察到标识部清晰度的变化，从而指示使用者正确使用液体检测装置，兼具快速的液体传导速度和较大吸液量，因此检测速度快、灵敏度高。本发明上述实施例仅例示性说明本发明的原理及其功效，而非用于限制本发明。任何本领域技术人员皆可在不违背本发明的精神及范畴下，对上述实施例进行修饰或改 变。因此，本领域技术人员在未脱离本发明所揭示的精神与技术思想下所完成的一切等效修饰或改变，仍应由本发明的权利要求所涵盖。

Claims (12)

  1. 一种吸液指示部件，其特征在于，所述吸液指示部件(3)包括：
    第一导液芯(31)；和
    第二导液芯(32)，所述第二导液芯(32)的外周表面上设置标识部，所述第一导液芯(31)全部或部分包覆所述第二导液芯(32)的所述标识部，
    所述第一导液芯(31)的透明度随着采集液体量的增加而提高。
  2. 如权利要求1所述的吸液指示部件，其特征在于，所述第一导液芯(31)由皮芯结构的双组份纤维粘结制成。
  3. 如权利要求2所述的吸液指示部件，其特征在于，所述双组份纤维的皮层含有聚乙烯、聚丙烯或聚烯烃中的至少一种。
  4. 如权利要求1所述的吸液指示部件，其特征在于，所述第一导液芯(31)由长丝或短纤制成。
  5. 如权利要求1所述的吸液指示部件，其特征在于，所述第一导液芯(31)的材料厚度为0.5-2mm。
  6. 如权利要求1所述的吸液指示部件，其特征在于，所述第二导液芯(32)由皮芯结构的双组份纤维粘结制成。
  7. 如权利要求1所述的吸液指示部件，其特征在于，所述标识部为颜色、图案或者文字。
  8. 如权利要求1所述的吸液指示部件，其特征在于，所述第二导液芯(32)由双组份长丝制成。
  9. 一种液体检测装置，其特征在于，所述液体检测装置(1)包括如权利要求1-8中任一项所述的吸液指示部件(3)。
  10. 如权利要求9所述的液体检测装置，其特征在于，所述液体检测装置(1)还包括：外壳(2)，
    容纳在所述外壳(2)中的多孔载体(4)；
    所述多孔载体(4)直接或者间接与所述吸液指示部件(3)连接，
    其中，所述多孔载体(4)具有检测区(41)，且所述外壳(2)在与所述检测区(41)对应的位置上设置有观察窗(21)。
  11. 如权利要求10所述的液体检测装置，其特征在于，所述液体检测装置(1)还包括在湿态下在所述多孔载体(4)中自由移动的标记的分析物特异性结合试剂，以及永久固定在多孔载体(4)的检测区(41)且在湿态下不能移动的针对同一分析物的未标记特异性结合试剂，所述标记的试剂和所述检测区(41)的相对位置使得加在所述液体检测装置(1)上的液 体携带所述标记的试剂并渗透进入所述检测区(41)。
  12. 如权利要求权10所述的检测装置，其特征在于，所述多孔载体(4)连接所述第一导液芯(31)、或所述第二导液芯(32)，或所述多孔载体(4)同时连接所述第一导液芯(31)和所述第二导液芯(32)。
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