WO2020007186A1

WO2020007186A1 - Lifting thread with toothed tube

Info

Publication number: WO2020007186A1
Application number: PCT/CN2019/091441
Authority: WO
Inventors: 包一红; 徐秀忠; 张志萍
Original assignee: 浙江中在医疗科技有限公司
Priority date: 2018-07-05
Filing date: 2019-06-15
Publication date: 2020-01-09
Also published as: CN108784766A; TW202014152A

Abstract

A lifting thread with a toothed tube for use in a plastic operation, comprising a thread body (1), wherein multiple thread knots (2) are distributed on the thread body (1); a toothed tube (3) is connected in series between the thread knots (2) on the thread body (1); the toothed tube (3) is a hollow tube body (4); the outer wall of the hollow tube body (4) is provided with one or more, two or more, or three or more teeth (5) that radially protrude from the tube body (4); the thread body (1) and the toothed tube (3) are made of an absorbable material. The lifting thread with the toothed tube of the present invention has good thread body strength and good tooth strength; tissue friction is increased by means of a toothed protrusion, so that a lifting force is greatly increased.

Description

Suspended line with toothed tube

Technical field

The invention relates to medical instruments, in particular to a suspension wire for plastic surgery.

Background technique

Suspension of skin tissue with absorbable or non-absorbable threads to achieve facial rejuvenation has been used for many years. The working principle is that the suspensory thread has a structural member that can generate resistance in the reverse direction. After it is introduced into the facial tissue by a suture needle, it is lifted in the opposite direction, and the generated reverse resistance will promote the tissue to improve. To achieve the goal of treating mild and moderate senile dysfunction.

This type of suspension line is mainly divided into three types in terms of its structure and method characteristics. One type is a suspension line composed of teeth that can generate resistance in the reverse direction. The second type is the whole. Thermoplastic suspension lines, including the full length of the body and the structural components that can generate resistance in the reverse direction are all suspension lines formed by hot pressing or injection molding; the third type is the structural components that can generate resistance in the reverse direction. A suspension line consisting of a hollow cone on a wire.

This type of suspension thread that is cut to form teeth is a single-stranded spinning thread that is strengthened by stretching and orientation. The teeth are generated by cutting the thread itself in a certain direction to form many inverted teeth. For example, CN101027168A discloses Barbed suture. The lifting principle is: when the suspending line enters the tissue, the direction of the teeth conforms to the direction of travel. When the pulling direction is reversed, the tip of the teeth inserts into the tissue and generates a pulling force to lift the tissue.

The whole thermoplastic suspension line is formed with many inverted teeth on the wire body by hot pressing or injection molding. The teeth grow from the wire body and are integrated with the wire body without cutting, such as Johnson's fish bone line. The lifting principle is the same as this type of suspension line that is cut to form teeth.

The hollow cone suspension thread is a hollow cone that is injection-molded and hung on a thread body. The thread body can be a single-stranded spinning thread reinforced by stretching and orientation, or a multi-strand braided thread, and along this line The body is knotted at regular intervals, and the hollow cone is fixed between every two knots, as disclosed in US7582105B2 and CN201404310Y. The principle of lifting is that when the suspending line enters the tissue, the direction of the smaller tip of the cone conforms to the direction of travel, and when pulling in the opposite direction, the tail of the larger cone generates reverse resistance, which drives the tissue to lift.

No matter what type of suspension line is, the most important thing for a lifting organization is the amount of lifting force.

Tooth suspension lines that are cut to form teeth. Because the tooth body is not hard enough, it is easy to deform, flip or break when pulled in the opposite direction, so the pulling strength of the tooth is also the smallest. At the same time, because the wire body is damaged by cutting, its tensile strength is also small , Easy to be pulled off, only suitable for pulling small parts with small pull requirements.

The overall thermoplastic suspension line has thicker teeth and higher pulling strength, but the tensile strength of the thread body is much smaller than that of a single-stranded spinning yarn of the same diameter. The same strength and processability of the strand spinning thread often requires increasing the diameter of the thread body, which may cause inflammatory reactions caused by too many implants or patient discomfort.

Hollow cone suspension line, its thread body is also a single-spun or multi-strand braided yarn reinforced by stretching orientation. The strength is greater, but the hollow cone has no tooth structure, but only depends on the reverse resistance of the cone. Pulling force is generated. If the pulling force is excessive, slipping may occur.

Summary of the invention

In view of the above deficiencies of the prior art, an object of the present invention is to provide a toothed tube suspension line, which has a higher strength and does not break or slip off when pulled.

A toothed pipe suspension line includes a wire body and a toothed pipe arranged in series on the wire body;

A wire knot for limiting the position of the toothed pipe is provided on the wire body;

The toothed tube includes a hollow tube body and teeth provided on the outer wall of the hollow tube and protruding outward.

The toothed tube suspension line is mainly composed of a thread body and a toothed tube. The thread body is a single-stranded spinning thread or a multi-strand braided wire reinforced by stretching and orientation, and has good thread body strength. The pipe is made of thermoplastic. Through the tooth-shaped protrusions on the pipe body, good tooth strength is achieved, and no breakage or slippage occurs during pulling.

Preferably, there are two or more toothed tubes, the diameters of the two ends of the hollow tube body are the same or close to each other, and the size of the knot is larger than the inner diameter of the hollow tube body.

Preferably, a cross section of a tooth root to a tooth tip of the tooth gradually decreases, and the tooth tip is inclined to one side along an axis of the hollow pipe body.

Preferably, each toothed tube is provided with three or more teeth, and the tip angles of all the teeth are the same.

In the present invention, the teeth are at any position on the hollow tube wall. Preferably, any two teeth are not on the same circumferential line of the hollow tube wall.

In the toothed tube, the two teeth of the toothed tube make an arbitrary angle along the circumferential direction. Preferably, there are three teeth outside the hollow tube, and each of the teeth forms an angle of 120 ° along the circumferential direction.

Preferably, the distance between two adjacent teeth (5) on the same hollow pipe body along the axial direction of the hollow pipe body is 0-5 mm.

Preferably, the length from the root of the tooth to the tip of the tooth is not more than 5 mm, and the width of the root of the tooth along the axial direction of the hollow pipe body is 0.1-4 mm, and the tooth of the tooth The thickness of the root along the circumferential direction of the hollow pipe body is greater than 0.2 mm.

Preferably, the inclination of the tooth tips of the teeth is 10-80 °, and the angle generally refers to an included angle between the tooth body and the axial direction of the hollow pipe.

Preferably, the knots distributed on the wire body may be knots knotted by the wire body itself or welded knots, and the distance between the two knots may be arbitrarily adjusted.

According to the toothed pipe suspension line of the present invention, the thread body is made of an absorbent material through stretch orientation or multi-strand braiding; the toothed pipe is made of an absorbable material by injection molding. Absorbable materials include: L-lactide, DL-lactide, glycolide, caprolactone, trimethylene carbonate, homopolymers or copolymers, homopolymers or copolymers of dioxocyclohexanone Of blends.

The toothed pipe suspension line of the present invention, wherein the material of the toothed pipe is an L-lactide / glycolide copolymer, and preferably, the molar percentage content of the L-lactide is 75% -95 %, The molar percentage content of glycolide is 5% -25%.

The toothed pipe suspension line of the present invention, wherein the material of the toothed pipe is an L-lactide / DL-lactide-containing copolymer, and preferably, the molar percentage content of L-lactide is 60 % -95%, and the molar percentage of DL-lactide is 5% -40%.

Compared with the prior art, the toothed pipe suspension line of the present invention has the following advantages:

(1) Compared with the overall thermoplastic suspension line, the pulling strength of the two teeth is equivalent. The thread body of the suspension line with a toothed tube of the present invention is a single-stranded spinning line or a multi-strand braid reinforced by stretching orientation. Thread, its thread body has greater tensile strength.

(2) Compared with the suspension line that is cut to form teeth, the structure of the suspension pipe with toothed tube of the present invention can generate resistance in the reverse direction is an injection-molded toothed tube. The tooth pull strength and the wire body tensile strength Both are larger, and at the same time, they have a stronger hooking force on soft tissues than the injection-molded hollow cone.

(3) The present invention combines the advantages of the overall thermoplastic suspension line with its strong pulling strength of the teeth and the strength of the hollow body of the hollow cone suspension line. Compared with the hollow cone suspension line, the tension strength of the two bodies is equivalent. The toothed tube suspension line of the present invention has a greater hooking and pulling force of the teeth on the tissue.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a schematic diagram of a toothed pipe suspension line according to the present invention.

FIG. 2 is a schematic view of a toothed tube on a toothed tube suspension line of the present invention.

The main reference signs are explained as follows:

1 is a thread body; 2 is a wire knot; 3 is a toothed tube; 4 is a hollow tube body; 5 is a tooth protruding outside the tube.

detailed description

The present invention is described in further detail below through specific implementations and in conjunction with the accompanying drawings.

FIG. 1 is a toothed pipe suspension line of the present invention. As can be seen from FIG. 1, the toothed pipe suspension line includes a woven or single-smooth smooth thread body 1, and a plurality of knots 2 are distributed on the thread body. A toothed tube 3 is connected in series between the wire knots on the thread body, the toothed tube is a hollow tube body 4, and the outer wall of the hollow tube is provided with teeth 5 protruding outside the tube body.

The number of toothed pipes 3 is generally three or more (only two are shown in FIG. 1), and the diameters of the two ends of the hollow pipe body are the same or close to each other. The teeth 5 protruding from the outside of the tube are composed of two or more teeth whose tooth tips are inclined in one direction, and can be randomly distributed on the tube.

FIG. 2 is a schematic structural diagram of a toothed pipe 3. As can be seen from FIG. 2, on the surface of the hollow pipe body 4, the relative positions of the two teeth on the pipe body are not on the same circumferential line; The teeth are arranged at any angle along the circumferential direction. Preferably, the two teeth are arranged at an angle of 120 ° along the circumferential direction.

As a common situation, there are three teeth 5 outside the tube, and each of the teeth has an angle of 120 ° along the circumferential direction.

The toothed pipe suspension line of the present invention, wherein the distance between each tooth of the teeth 5 protruding outside the pipe body along the longitudinal direction of the pipe body is 0-5 mm.

In the toothed pipe suspension line of the present invention, the inclination of the tooth tips of the teeth 5 protruding outside the pipe is 10-80 °.

According to the toothed pipe suspension wire of the present invention, the knots 2 distributed on the wire body can be knots welded by the wire body or welded knots, and the distance between the two knots can be arbitrarily adjusted; The size is larger than the inner diameter of the tube.

The toothed pipe suspension line of the present invention, wherein the thread body and the toothed pipe are made of an absorbable material, and the absorbable material includes: L-lactide, DL-lactide, glycolide, caprolactone Homopolymers or copolymers of esters, trimethylene carbonate, p-dioxane, blends of homopolymers or copolymers.

The toothed pipe suspension line of the present invention is further described below in combination with specific embodiments.

Example 1

Polyε-caprolactone (PCL) was made into a single strand by melt spinning with a diameter of 0.35 mm, a length of 10 cm, and a breaking force of 26 N (N).

Example 2

Poly-L-lactide (PLLA) was made into a multi-strand braided wire body by melt spinning with a diameter of 0.30 mm, a wire body length of 10 cm, and a wire breaking force of 38 N (N).

Example 3

Poly-L-lactide / glycolide copolymer was used to make a toothed pipe by injection molding. The outer diameter of the pipe body was 0.70 mm, the inner diameter was 0.30 mm, and the length was 3 mm. The height is 0.5mm, the distance between the two tooth tips is 0.7mm, and each tooth forms an angle of 120 ° along the circumferential direction.

The synthesis of poly-L-lactide / glycolide copolymer can be synthesized by published conventional methods. The proportion is adjusted according to actual needs. The molar percentage of L-lactide is 75% -95%, and the molar percentage of glycolide is 5% -25%.

Example 4:

A total of 5 toothed tubes in Example 3 were threaded on the thread body in Example 1, and the tooth directions on each toothed tube were the same, and then the toothed tubes were manually knotted to separate the toothed tubes.

Example 5

One end of the suspension thread prepared in Example 4 is connected with a straight puncture needle, and the other end can be connected with a curved surgical suture needle.

Example 6

The suspension line of Example 5 was guided through the foam material of the simulated tissue through the puncture needle in accordance with the direction of the teeth. After all the toothed tubes entered the foam material, they were pulled outwards in the direction opposite to the teeth, using a mechanical testing machine The test pull strength was 21N.

Example 7

According to the technical content of US7582105B2, a cone wire is prepared. A hollow cone was made by injection molding, with a length of 3.0 mm, a large diameter of 1.42 mm, and a small diameter of 0.6 mm. Five of them were threaded on the thread body in Example 1, and the directions of the major and minor diameters of each cone were the same, and the hollow cones were separated by knotting manually. The puncture needle was connected according to Example 5 and tested according to the method of Example 6. The pulling force was 11N.

The results of Examples 6 and 7 show that when the hollow cone and the toothed tube are used with similar dimensions and the same number, the toothed tube suspension line of the present invention can significantly increase the pulling force.

Example 8

A total of eight toothed tubes in Example 3 were threaded on the thread body in Example 2. The teeth on each toothed tube were in the same direction, and the toothed tubes were manually knotted to separate the toothed tubes. The puncture needle was connected according to Example 5 and tested according to the method of Example 6. The pulling force was 35N.

Example 9

According to the technical content of US7582105B2, a cone wire is prepared. A hollow cone was made by injection molding, with a length of 3.0 mm, a large diameter of 1.42 mm, and a small diameter of 0.6 mm. Eight of them were threaded on the thread body in Example 2. The directions of the major and minor diameters of each cone were the same, and the hollow cones were separated by knotting. The puncture needle was connected according to Example 5 and tested according to the method of Example 6. The pulling force was 16N.

The results of Examples 8 and 9 show that when the hollow cone and the toothed tube are used with similar dimensions and the same number, the toothed tube suspension line of the present invention can significantly increase the pulling force.

Claims

A toothed pipe suspension line is characterized in that it comprises a wire body (1) and a toothed pipe (3) arranged in series on the wire body (1);

The wire body (1) is provided with a wire knot (2) for limiting the position of the toothed pipe (3);

The toothed pipe (3) includes a hollow pipe body (4) and teeth (5) arranged on the outer wall of the hollow pipe body (4) and protruding outward.
The toothed pipe suspension line according to claim 1, characterized in that there are two or more toothed pipes (3), and the diameters of the two ends of the hollow pipe body (4) are the same Or close, the size of the knot (2) is larger than the inner diameter of the hollow pipe body (4).
The suspension line with a toothed tube according to claim 1, characterized in that the section from the tooth root to the tooth tip of the tooth (5) gradually decreases, and the tooth tip is along the hollow pipe body (4) The axis is inclined to one side.
The toothed pipe suspension line according to claim 3, wherein each toothed pipe (3) is provided with three or more teeth (5), and the tooth tips of all the teeth (5) are inclined The same direction

Any two teeth (5) are not on the same circumferential line of the hollow tube wall.
The toothed pipe suspension line according to claim 4, wherein there are three teeth (5) outside the hollow tube, and each of the teeth forms an angle of 120 ° along the circumferential direction.
The toothed pipe suspension line according to any one of claims 1 to 5, characterized in that between two adjacent teeth (5) on the same hollow pipe body (4) are along the hollow pipe The distance of the body (4) in the axial direction is 0-5 mm.
The toothed pipe suspension line according to any one of claims 1 to 5, characterized in that the length from the root to the tip of the tooth (5) is not more than 5 mm, and the tooth (5) The width of the root of the tooth along the axial direction of the hollow pipe body (4) is 0.1-4mm, and the thickness of the tooth root of the tooth (5) along the circumferential direction of the hollow pipe body (4) is greater than 0.2mm.
The toothed pipe suspension line according to any one of claims 1 to 6, wherein the inclination of the tip of the tooth (5) is 10-80 °.
The suspension line with a toothed tube according to claim 1, wherein the wire body and the toothed tube are made of an absorbable material;

The absorbable material is L-lactide, DL-lactide, glycolide, caprolactone, trimethylene carbonate, homopolymer or copolymer of homodioxycyclohexanone, homopolymer Or a blend of copolymers.
The suspension line with a toothed tube according to claim 1 or 9, wherein the material of the toothed tube is L-lactide / glycolide copolymer or L-lactide / DL-propylene Lactide copolymer

Preferably, in the L-lactide / glycolide copolymer, the molar percentage of L-lactide is 75% -95%, and the molar percentage of glycolide is 5% -25%;

In the L-lactide / DL-lactide copolymer, the molar percentage of L-lactide is 60-95%, and the molar percentage of DL-lactide is 5% -40%.