WO2019246593A3 - Compositions and methods to target cll-1 and cd123 for the treatment of acute myeloid leukemia and related disorders - Google Patents

Compositions and methods to target cll-1 and cd123 for the treatment of acute myeloid leukemia and related disorders Download PDF

Info

Publication number
WO2019246593A3
WO2019246593A3 PCT/US2019/038596 US2019038596W WO2019246593A3 WO 2019246593 A3 WO2019246593 A3 WO 2019246593A3 US 2019038596 W US2019038596 W US 2019038596W WO 2019246593 A3 WO2019246593 A3 WO 2019246593A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
treatment
methods
myeloid leukemia
related disorders
Prior art date
Application number
PCT/US2019/038596
Other languages
French (fr)
Other versions
WO2019246593A2 (en
Inventor
Cameron J. Turtle
Sajid Mahmood
Kevin A. Hay
Original Assignee
Fred Hutchinson Cancer Research Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fred Hutchinson Cancer Research Center filed Critical Fred Hutchinson Cancer Research Center
Publication of WO2019246593A2 publication Critical patent/WO2019246593A2/en
Publication of WO2019246593A3 publication Critical patent/WO2019246593A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16044—Chimeric viral vector comprising heterologous viral elements for production of another viral vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Compositions and methods to target C-type lectin-like molecule-1 (CLL-1) and interleukin-3 receptor (CD123) for the treatment of acute myeloid leukemia and related disorders are described. The disclosure describes multiple strategies to target CLL-1 and CD123 utilizing multiple chimeric antigen receptor (CAR) system designs.
PCT/US2019/038596 2018-06-22 2019-06-21 Compositions and methods to target cll-1 and cd123 for the treatment of acute myeloid leukemia and related disorders WO2019246593A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862688674P 2018-06-22 2018-06-22
US62/688,674 2018-06-22

Publications (2)

Publication Number Publication Date
WO2019246593A2 WO2019246593A2 (en) 2019-12-26
WO2019246593A3 true WO2019246593A3 (en) 2020-01-30

Family

ID=68983099

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2019/038596 WO2019246593A2 (en) 2018-06-22 2019-06-21 Compositions and methods to target cll-1 and cd123 for the treatment of acute myeloid leukemia and related disorders

Country Status (1)

Country Link
WO (1) WO2019246593A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230151094A1 (en) * 2020-03-31 2023-05-18 Fred Hutchinson Cancer Center Chimeric antigen receptors targeting cd33
WO2023154890A2 (en) * 2022-02-11 2023-08-17 Fred Hutchinson Cancer Center Chimeric antigen receptors binding steap1

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070179091A1 (en) * 2005-12-27 2007-08-02 Genentech, Inc. Hedgehog Kinases and Their Use in Modulating Hedgehog Signaling
US20080241884A1 (en) * 2003-10-08 2008-10-02 Kenya Shitara Fused Protein Composition
US20100184671A1 (en) * 2003-06-25 2010-07-22 Crucell Holland B.V. Binding molecules for the treatment of myeloid cell malignancies
US20120328619A1 (en) * 2009-12-09 2012-12-27 Fey Georg H Trispecific Therapeutics Against Acute Myeloid Leukaemia
WO2016120218A1 (en) * 2015-01-26 2016-08-04 Cellectis ANTI-CLL1 SPECIFIC SINGLE-CHAIN CHIMERIC ANTIGEN RECEPTORS (scCARS) FOR CANCER IMMUNOTHERAPY
US20170014508A1 (en) * 2014-04-01 2017-01-19 Ucl Business Plc Chimeric antigen receptor (car) signalling system
US20180162939A1 (en) * 2016-06-24 2018-06-14 Icell Gene Therapeutics Llc CHIMERIC ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS THEREOF

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100184671A1 (en) * 2003-06-25 2010-07-22 Crucell Holland B.V. Binding molecules for the treatment of myeloid cell malignancies
US20080241884A1 (en) * 2003-10-08 2008-10-02 Kenya Shitara Fused Protein Composition
US20070179091A1 (en) * 2005-12-27 2007-08-02 Genentech, Inc. Hedgehog Kinases and Their Use in Modulating Hedgehog Signaling
US20120328619A1 (en) * 2009-12-09 2012-12-27 Fey Georg H Trispecific Therapeutics Against Acute Myeloid Leukaemia
US20170014508A1 (en) * 2014-04-01 2017-01-19 Ucl Business Plc Chimeric antigen receptor (car) signalling system
WO2016120218A1 (en) * 2015-01-26 2016-08-04 Cellectis ANTI-CLL1 SPECIFIC SINGLE-CHAIN CHIMERIC ANTIGEN RECEPTORS (scCARS) FOR CANCER IMMUNOTHERAPY
US20180002427A1 (en) * 2015-01-26 2018-01-04 Cellectis Cll1-specific multi-chain chimeric antigen receptor
US20180009895A1 (en) * 2015-01-26 2018-01-11 Cellectis Anti-cll1 specific single-chain chimeric antigen receptors (sccars) for cancer immunotherapy
US20180162939A1 (en) * 2016-06-24 2018-06-14 Icell Gene Therapeutics Llc CHIMERIC ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS THEREOF

Also Published As

Publication number Publication date
WO2019246593A2 (en) 2019-12-26

Similar Documents

Publication Publication Date Title
WO2017184619A3 (en) Agonistic antibodies that bind human cd40 and uses thereof
WO2019224711A3 (en) Anti-cd33 antibodies, anti-cd33/anti-cd3 bispecific antibodies and uses thereof
WO2018017864A3 (en) Pvrig-binding agents and uses thereof
WO2018026819A3 (en) Treatment of cancer using a chimeric antigen receptor in combination with an inhibitor of a pro-m2 macrophage molecule
ZA202004730B (en) Anti-claudin 18.2 antibodies and uses thereof
CL2019003000A1 (en) Trem2 antigen binding proteins and their uses.
WO2016191643A3 (en) Tigit-binding agents and uses thereof
WO2020047449A9 (en) Methods of making chimeric antigen receptor-expressing cells
PH12021550764A1 (en) Trem2 stabilizing antibodies
JP2017518258A5 (en)
MX2021005396A (en) Anti-cd73 antibody, antigen-binding fragment thereof and application thereof.
MX2020003087A (en) Novel anti-cd3epsilon antibodies.
WO2019246593A3 (en) Compositions and methods to target cll-1 and cd123 for the treatment of acute myeloid leukemia and related disorders
WO2015157238A3 (en) Binding molecules specific for il-21 and uses thereof
WO2020121195A8 (en) Trem2 antibodies and uses thereof
WO2017049038A3 (en) Anti-cd115 antibodies
WO2015179400A3 (en) Methods for characterizing and treating acute myeloid leukemia
MX2020005364A (en) Anti-ox40 antibodies and uses thereof.
MX2020013885A (en) Anti-cd40 antibodies for use in treating autoimmune disease.
PH12020552006A1 (en) Antibodies specific for cd3 and uses thereof
EP3929214A4 (en) Antibody or chimeric antigen receptor which targets claudin 18.2
PH12019502694A1 (en) Anti-trkb antibodies
MX2021007119A (en) Methods of producing heterodimeric antibodies.
MX2021004916A (en) Novel rationally designed protein compositions.
MX2021000688A (en) Anti-cd40 antibodies and uses thereof.

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 19823269

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 19823269

Country of ref document: EP

Kind code of ref document: A2