WO2019235669A1

WO2019235669A1 - Smart contact lens for monitoring intraocular pressure and method for manufacturing same

Info

Publication number: WO2019235669A1
Application number: PCT/KR2018/006562
Authority: WO
Inventors: 박장웅; 김주희; 박지훈; 주서영
Original assignee: 울산과학기술원
Priority date: 2018-06-08
Filing date: 2018-06-11
Publication date: 2019-12-12
Also published as: KR102075143B1; KR20190139533A

Abstract

The present invention has a hybrid substrate inside a contact lens and has a strain sensor on a soft portion between the end parts of a rigid body portion of the hybrid substrate. Therefore, since the strain due to the intraocular pressure is amplified in the soft portion, the strain due to the intraocular pressure can be amplified and detected without the necessity of a separate amplifier circuit having a complex structure. The present invention allows comfort and flexibility by means of positioning the hybrid substrate on the outer side of a spiral-shaped antenna coil and minimizing the rigid body portion area, and has a simple structure and thus enables easy manufacture. The present invention allows flexibility by means of forming a flexible interconnect by 3D printing a liquid metal, and also facilitates connection regardless of a step between a wireless communication chip and an electrode.

Description

Smart contact lens for intraocular pressure monitoring and its manufacturing method

The present invention relates to a smart contact lens for intraocular pressure monitoring and a manufacturing method thereof, and more particularly to a smart contact lens for intraocular pressure monitoring and a method for manufacturing the same that can be measured by amplifying the strain according to the change in intraocular pressure.

In general, intraocular pressure refers to the pressure inside the eye. Intraocular pressure is an important indicator for the diagnosis and treatment of glaucoma.

Conventionally, in order to measure the intraocular pressure, the patient visited an ophthalmology hospital and measured the intraocular pressure through an intraocular pressure measurement device such as an tonometer in the hospital. However, the intraocular pressure continues to change in real time, and the intraocular pressure rises, especially in response to a drop in blood pressure at night.

Therefore, in recent years, in order to prevent glaucoma or to measure accurate intraocular pressure, interest in contact lenses capable of measuring intraocular pressure in real time has increased.

However, a conventional contact lens capable of measuring intraocular pressure has a complex signal amplification circuit such as a Wheatstone bridge circuit for amplifying a sensing signal to detect strain due to changes in intraocular pressure. There is a limit to this.

It is an object of the present invention to provide a smart contact lens for intraocular pressure monitoring and a method of manufacturing the same that can be detected by amplifying the strain according to the intraocular pressure.

The smart contact lens for intraocular pressure monitoring according to the present invention comprises: a flexible substrate formed of a contact lens material; An antenna coil embedded in the stretchable substrate, formed of a metal nanomaterial, and spaced apart from each other and formed in a spiral shape, wirelessly receiving power from the outside and performing electromagnetic resonance to wirelessly transmit a signal to the outside; A rigid body part embedded in the flexible substrate and formed in a circular arc shape having a predetermined length and a rigid material formed at a predetermined distance radially spaced apart from an outer circumference of the antenna coil, and positioned between an end portion of the rigid body part; And a soft part formed of a soft material having a modulus different from the rigid material by a predetermined value or more; The resistance wire is arranged long along the circumferential direction in the soft part so that the strain according to the intraocular pressure, and the terminal is disposed in the rigid part, the sensitivity is adjusted according to the ratio of the circumferential length of the rigid part and the circumferential length of the soft part. A strain sensor; A sensor connection electrode provided on the rigid body and connected to the strain sensor; Antenna connection electrodes connected to both ends of the antenna coil; A wireless communication chip for transmitting the information measured by the strain sensor to the outside through a wireless communication method; And a stretchable interconnect formed by three-dimensional printing of liquid metal to connect the wireless communication chip and the sensor connection electrode and to connect the other side of the wireless communication chip with the antenna connection electrode.

Smart contact lens for intraocular pressure monitoring according to another aspect of the present invention, the stretchable substrate formed of a contact lens material; An antenna embedded in the flexible substrate, formed of silver nanofibers and silver nanowires, and both ends thereof are spaced apart from each other and formed in a spiral shape to wirelessly receive power from the outside and perform electromagnetic resonance to wirelessly transmit a signal to the outside; A coil; A rigid body part embedded in the flexible substrate and formed of an arc shape having a preset length and formed of epoxy at a position spaced from the outer circumference of the antenna coil in a radially spaced distance from the outer circumference of the antenna coil; A hybrid substrate comprising a soft portion; The resistance wire is arranged long along the circumferential direction in the soft part so that the strain according to the intraocular pressure, and the terminal is disposed in the rigid part, the sensitivity is adjusted according to the ratio of the circumferential length of the rigid part and the circumferential length of the soft part. A strain sensor formed of silicon; A sensor connection electrode provided on the rigid body and connected to the strain sensor; Antenna connection electrodes connected to both ends of the antenna coil; An NFC chip transmitting the information measured by the strain sensor to the outside through a short range wireless communication method; It is formed by three-dimensional printing the liquid metal, and includes a flexible interconnect connecting the NFC chip and the sensor connection electrode, and the other side of the NFC chip and the antenna connection electrode.

The present invention provides a hybrid substrate inside the contact lens and a strain sensor in the soft portion located between the ends of the rigid portion of the hybrid substrate, so that deformation due to intraocular pressure is suppressed in the rigid portion and amplified in the soft portion. There is an advantage that can be detected by amplifying the deformation according to intraocular pressure without having to provide a separate amplification circuit of a complicated structure.

In addition, the hybrid substrate may be disposed outside the spiral antenna coil to minimize the rigid area, thereby ensuring a comfortable fit and elasticity, and the structure may be simple to manufacture.

In addition, the sensitivity of the strain sensor may be controlled by adjusting the ratio of the rigid and soft portions of the hybrid substrate.

In addition, by forming the flexible interconnect by three-dimensional printing the liquid metal, not only the elasticity can be secured, but also there is an advantage that the connection is easy even if there is a step between the chip and the electrode for wireless communication.

1 is a perspective view illustrating a smart contact lens for intraocular pressure monitoring according to an embodiment of the present invention.

FIG. 2 is a view schematically illustrating an antenna coil of the smart contact lens illustrated in FIG. 1.

3 is a diagram schematically illustrating a hybrid substrate of the smart contact lens illustrated in FIG. 1.

4 is a diagram illustrating strain amplification of the hybrid substrate illustrated in FIG. 3.

5 to 7 are views showing a method of manufacturing a smart contact lens for intraocular pressure monitoring according to an embodiment of the present invention.

8 is a view showing a step of manufacturing in the shape of a contact lens in the manufacturing method of the smart contact lens for intraocular pressure monitoring according to an embodiment of the present invention.

9 is a graph showing changes in the length of a soft part according to an area ratio of a rigid part and a soft part of a hybrid substrate according to an exemplary embodiment of the present invention.

10 is a graph showing the sensitivity of the strain sensor according to the area ratio of the rigid portion and the soft portion of the hybrid substrate according to the embodiment of the present invention.

FIG. 11 is a graph comparing an antenna coil and a copper antenna formed of a metal nanomaterial in an intraocular pressure monitoring smart contact lens according to an embodiment of the present invention using a relationship between a frequency and a reflection coefficient.

FIG. 12 is a graph comparing an antenna coil and a copper antenna formed of metal nanomaterials with resistance change according to strain in an IOP monitoring smart contact lens according to an exemplary embodiment of the present invention.

FIG. 13 is a graph showing a correlation between a smart contact lens for intraocular pressure monitoring according to an embodiment of the present invention and a conventional tonometer. FIG.

14 is a graph showing the results of measuring intraocular pressure in rabbits using a smart contact lens for intraocular pressure monitoring and a conventional tonometer according to an embodiment of the present invention.

FIG. 15 is a graph illustrating reproducibility according to a user using a smart contact lens for intraocular pressure monitoring and a conventional tonometer according to an embodiment of the present invention.

Hereinafter, an embodiment of the present invention will be described with reference to the accompanying drawings.

1 is a perspective view illustrating a smart contact lens for intraocular pressure monitoring according to an embodiment of the present invention. FIG. 2 is a view schematically illustrating an antenna coil of the smart contact lens illustrated in FIG. 1. 3 is a diagram schematically illustrating a hybrid substrate of the smart contact lens illustrated in FIG. 1. 4 is a diagram illustrating strain amplification of the hybrid substrate illustrated in FIG. 3.

Referring to FIG. 1, the smart contact lens for intraocular pressure monitoring according to an embodiment of the present invention may include a stretchable substrate 10, an antenna coil 20, a hybrid substrate 30, a strain sensor 40, and a sensor connection electrode 50. ), An antenna connection electrode 60, a wireless communication chip 70, and a flexible interconnect 80.

The stretchable substrate 10 is a light transmissive substrate formed of a transparent and stretchable material. The stretchable substrate 10 may of course be transparent or translucent.

The stretchable substrate 10 includes both a passivation layer 10a formed of a first stretchable material, a protective layer 10b formed of a second stretchable material, and a contact lens material 110.

The first elastic material may include parylene, the second elastic material may include epoxy, and the contact lens material 110 may include hydrogel or silicone. . However, the present invention is not limited thereto, and the first stretchable material, the second stretchable material, and the contact lens material 110 may all use the same material or some materials may be the same and others may use different materials.

Referring to FIG. 2, the antenna coil 20 is embedded in the stretchable substrate 10. The antenna coil 20 may include at least one of a one-dimensional metal nanomaterial and a two-dimensional metal nanomaterial.

The antenna coil 20 will be described, for example, as being formed by including silver nanofibers and silver nanowires, which are one-dimensional metal nanomaterials. Therefore, the antenna coil 20 may secure transparency and elasticity for securing a field of view.

The antenna coil 20 is patterned in a shape in which both ends are spaced apart from each other and wound in a spiral shape, and wirelessly receive power from the outside and perform electromagnetic resonance to wirelessly transmit the outside. The antenna coil 20 is formed to enable wireless communication using Bluetooth or NFC. The antenna coil 20 is designed to have a resonance frequency of 12 to 15 MHz for NFC wireless communication, or to have a resonance frequency of 2 to 3 GHz for Bluetooth wireless communication.

Referring to FIG. 3, the hybrid substrate 30 is a substrate formed of different materials in which a difference in modulus differs by a set value or more.

The hybrid substrate 30 includes a rigid area 31 formed of a rigid material, and a soft area 32 formed between soft ends and positioned between ends of the rigid part 31. do.

The rigid material and the soft material are set to materials whose modulus differs by more than a preset value.

Epoxy may be used for the rigid material. In the present embodiment, an example is described using SU8 (E = 4 Gpa).

The soft material may be silicone usable as a contact lens material. In the present embodiment will be described using an example elastofilcon A (E = ~ 0.09Mpa).

The rigid part 31 is formed at a position spaced apart from the outside of the antenna coil 20 by a predetermined interval in the radial direction, and is formed in an arc shape having a preset length. For example, three rigid parts 31 are formed to be spaced apart from each other by a predetermined distance in the circumferential direction. However, the present invention is not limited thereto and may be a shape that is symmetrically formed around the strain sensor 40.

The rigid part 31 is formed by coating the rigid material with a thickness in the range of 40 to 60 μm, and then patterning it in a plurality of arc shapes. In the present embodiment, the thickness of the rigid body portion 31 is 50 μm, for example.

The soft portion 32 is formed between the ends of the rigid portion 31. However, the present invention is not limited thereto, and the soft part 32 may cover both the upper side of the rigid part 31 and the upper side of the antenna coil 20 while filling between end portions of the rigid part 31.

The soft portion 32 is formed by coating the soft material to a thickness in the range of 90 to 110㎛. In the present embodiment, the thickness of the soft portion 32 is about 100 μm, which will be described by way of example. The soft part 32 is formed thicker than the rigid part 31 to protect the wireless communication chip 70 and the flexible interconnect 80.

The hybrid substrate 30 is formed such that the circumferential length of the rigid portion 31 is set to 3 to 10 times the circumferential length of the soft portion 32.

The amplification effect of the strain measured by the strain sensor 40 varies according to the ratio of the circumferential length of the rigid part 31 and the circumferential length of the soft part 32. Therefore, by adjusting the ratio of the circumferential length of the rigid portion 31 and the circumferential length of the soft portion 32, the strain amplification effect of the strain sensor 40 is adjusted to adjust the sensitivity of the strain sensor 40. Controllable.

In the present embodiment, the ratio between the total lengths L1 and L1 = L2 of the rigid part 31 and the length L0 of the soft part 32 is about 9: 1.

The strain sensor 40 is a sensor that detects strain due to intraocular pressure. The strain sensor 40 is provided in the soft part 32 to detect and amplify the strain according to the intraocular pressure.

The resistance wire 40a of the strain sensor 40 is provided along the circumferential direction in the soft part 32. The terminal 40b of the strain sensor 40 is provided in the rigid part 31.

The strain sensor 40 is a silicon nanomembrane-based sensor. The strain sensor 40 is formed to a nano-thickness using silicon.

The silicon used for the strain sensor 40 is a different material from silicon used as the contact lens material. The silicon used in the strain sensor 40 refers to silicon represented by Si. On the other hand, silicon used as the contact lens material refers to a polymer in which a silicon (organosilicone) containing an organic group and oxygen are connected to each other by a chemical bond.

The sensor connection electrode 50 is an electrode provided in the rigid part 31 and connected to the terminal 40b of the strain sensor 40. The sensor connection electrode 50 may be formed of a metal material or a transparent electrode including a nanocomposite. The sensor connection electrode 50 may include a 1D metal nanomaterial and a 2D metal nanomaterial.

The antenna connection electrode 60 is an electrode connected to both ends of the antenna coil 20, respectively. The antenna connection electrode 60 may be formed of a metal material or a transparent electrode including a nanocomposite. The antenna connection electrode 60 may be formed to include a 1D metal nanomaterial and a 2D metal nanomaterial.

The chip for wireless communication 70 is a chip for transmitting information measured by the strain sensor 40 to the outside through a wireless communication method. The wireless communication chip 70 is described as an NFC chip, for example.

The flexible interconnect 80 includes connecting the wireless communication chip 70 and the sensor connection electrode 50, and connecting the wireless communication chip 70 and the antenna connection electrode 60.

The flexible interconnect 80 is formed by three-dimensional printing of a liquid metal, so that elasticity can be ensured even when deformation due to intraocular pressure or other factors. In addition, the stretchable interconnect 80 is formed by three-dimensional printing, so that the step between the wireless communication chip 70 and the sensor connection electrode 50, the wireless communication chip 70 and the antenna connection electrode 60 Can be connected without being limited by the step between them. The width or thickness of the flexible interconnect 80 is adjustable through the nozzle size of the three-dimensional printer.

Referring to the manufacturing method of the smart contact lens for intraocular pressure monitoring according to an embodiment of the present invention configured as described above are as follows.

Referring to FIG. 5A, the sacrificial layer 4 is coated on the mother substrate 2.

Referring to FIG. 5B, the strain sensor 40 is transferred onto the sacrificial layer 4.

Referring to FIG. 5C, the sensor connection electrode 50 and the antenna connection electrode 60 are deposited.

The sensor connection electrode 50 and the antenna connection electrode 60 may be formed by depositing an electrode material and patterning the electrode material in a predetermined shape. The sensor connection electrode 50 is patterned to be connected to the terminal portion 40b of the strain sensor 40.

Subsequently, referring to FIG. 5D, the antenna coil 20 is formed.

After the antenna coil 20 is formed of silver nanofibers through electrospinning, the silver nanowires are coated by an electrospray method to form a metal nanomaterial layer, and then the metal nanomaterial layer is spiraled. It is formed by patterning the antenna pattern of the shape.

6A, a passivation layer 10a is formed by coating the first elastic material on the antenna coil 20.

The passivation layer 10a is formed in a circular shape. The passivation layer 10a can prevent short circuits in future flexible interconnect connections.

After forming the passivation layer 10a, a via hole is formed to expose the strain sensor 40, the sensor connection electrode 50, and the antenna connection electrode 60.

6B, the hybrid substrate 30 is formed on the passivation layer 10a.

In order to form the hybrid substrate 30, the rigid material is first coated to form a rigid layer, and then patterned into a predetermined shape of the rigid part 31.

The rigid part 31 is formed at a position spaced apart from the outer circumference of the antenna coil 20 by a predetermined distance in a radial direction, and is formed to cover the sensor connection electrode 50 so that the sensor connection electrode 50 is formed. It is to be provided in the rigid body portion 31.

The rigid part 31 may have a single arc shape having at least one side open, and may have a shape in which a plurality of arcs are spaced apart from each other by a predetermined distance. In the present embodiment, the rigid body portion 31 will be described with an example in which three arcs are arranged to be spaced apart from each other by a predetermined interval. However, the present invention is not limited thereto, and the rigid body 31 may have a shape in which both left and right sides are symmetrical with respect to the strain sensor 40. When the strain sensor 40 is formed in a symmetrical structure, the strain sensor 40 may be more accurately and stably amplified.

After the rigid portion 31 is formed, the soft material is coated to form the soft portion 32.

The soft material may be silicone which can be used as a contact lens material. In the present embodiment will be described using an example elastofilcon A (E = ~ 0.09Mpa).

The soft part 32 is a soft layer formed in a circular shape similar to that of the passivation layer 10a to cover the passivation layer 10a and the rigid part 31. It demonstrates as an example. However, the present invention is not limited thereto, and the soft part 32 may have any shape as long as it is formed in an area between the ends of the rigid part 31 to cover the strain sensor 40.

When the soft part 32 is formed, the strain sensor 40 is positioned in the soft part 32.

6C, the wireless communication chip 70 is mounted.

The wireless communication chip 70 may be disposed in close proximity to both ends of the antenna coil 20.

Referring now to FIG. 7A, the stretchable interconnect 80 is formed.

The stretchable interconnect 80 is formed by three-dimensional printing a liquid metal using a three-dimensional printer. The flexible interconnect 80 connects one side of the wireless communication chip 70 and the sensor connection electrode 50 and prints the other side of the wireless communication chip 70 and the antenna connection electrode 60. .

Since the flexible interconnect 80 uses liquid metal, not only the elasticity can be secured, but also the three-dimensional printing can be easily patterned into a desired shape. In addition, the flexible interconnect 80 is formed by three-dimensional printing of a liquid metal, so that the radio communication chip 70 and the antenna connection electrode 60, or the radio communication chip 70 and the sensor connection electrode. Even if there is a step between the 50, the connection is possible.

Referring to FIG. 7B, the second stretchable material may be coated to form a protective layer 10b to protect the stretchable interconnect 80, the strain sensor 40, and the wireless communication chip 70. Form a package.

Referring to FIG. 7C, the sacrificial layer 4 is removed to separate the device from the mother substrate 2.

Referring to FIG. 8, the stretchable package from which the sacrificial layer 4 is removed is placed in a molding mold 100, pressurized, and cured to form a contact lens.

The contact lens may be completed by inserting the contact lens material and the stretchable package into the concave lens lower mold 102 and pressing the convex lens upper mold 101 at a predetermined pressure.

However, the present invention is not limited thereto, and the stretchable package may be transferred to a contact lens manufactured in advance.

Referring to the method of using the smart contact lens for intraocular pressure monitoring according to the present invention manufactured by the above method, as follows.

After the user wears the smart contact lens, when the intraocular pressure increases, deformation occurs according to the intraocular pressure.

In this case, since the smart contact lens includes the hybrid substrate 30, when the intraocular pressure is increased, the deformation is suppressed in the rigid part 31 so that the soft part 32 is positioned between the rigid part 31. Deformation may be concentrated relative to the rigid part 31.

When deformation occurs in the soft part 32, the strain sensor 40 provided in the soft part 32 may detect the strain rate.

Since the deformation suppressed in the rigid part 31 is amplified relatively concentrated in the soft part 32, the strain amplified by the strain sensor 40 can be obtained.

The strain sensor 40 can effectively detect the minute strain because the strain is amplified and sensed even if a minute strain occurs due to a small intraocular pressure.

The value sensed by the strain sensor 40 may be transmitted to an external terminal such as a smartphone through the wireless communication chip 70.

4 and 9, the strain amplification effect according to the ratio of the area of the rigid portion 31 and the soft portion 32 of the hybrid substrate 30 can be seen.

Referring to FIG. 9, it can be seen that the change in the length of the soft part 31 increases linearly with the strain rate, and the increase ratio is the total length L1 of the rigid part 31 and the total length of the elastic part. It can be seen that the proportion increases with the ratio of (L0).

That is, when the ratio of the total length L1 of the rigid part 31 and the total length L0 of the elastic part is 9: 1, it can be seen that the rate of change of the length of the soft part 31 increases the most. .

Accordingly, it can be seen that the ratio of the total length L1 of the rigid part 31 to the total length L0 of the elastic part is 9: 1.

Referring to FIG. 10, it can be seen that the change rate of resistance to intraocular pressure in the strain sensor 40 increases linearly, wherein the increase rate is the total length L1 of the rigid part 31 and the length of the elastic part. It can be seen that the proportion increases with the ratio of (L0).

That is, when the ratio of the total length L1 of the rigid part 31 to the length L0 of the elastic part is 9: 1, it can be seen that the sensitivity of the strain sensor 40 is the greatest.

Referring to FIG. 11, the antenna coil 20 according to the present invention is manufactured to have a resonance frequency of 13.56 MHz for wireless communication.

FIG. 12 is a graph comparing an antenna coil and a copper antenna formed of metal nanomaterials with resistance change according to strain in an intraocular pressure monitoring smart contact lens according to an exemplary embodiment of the present invention.

Referring to FIG. 12, the antenna coil 20 formed of the silver nanofibers and the silver nanowires has a resistance change rate of less than 1.5% at 30% tensile strain as compared to a copper antenna used in the related art.

That is, it can be seen that the antenna coil 20 has excellent mechanical elasticity.

Therefore, it can be seen that the antenna coil 20 according to the present invention has similar characteristics as compared with a conventional copper antenna and has excellent elasticity.

FIG. 13 is a graph showing a correlation between a smart contact lens for intraocular pressure monitoring according to an embodiment of the present invention and a conventional tonometer. FIG. 14 is a graph showing the results of measuring intraocular pressure in rabbits using a smart contact lens for intraocular pressure monitoring and a conventional tonometer according to an embodiment of the present invention.

13 and 14, it can be seen that there is a high correlation between the actual intraocular pressure measured by the tonometer and the intraocular pressure measured by the smart contact lens according to the present invention.

In addition, the intermediate intersession correlation coefficient (ICC) is about 0.888, indicating that the cross reproducibility is very good.

Referring to FIG. 15, as a result of experimenting with different users (operator1, operator2), the smart contact lens according to the present invention is not affected by the user, unlike the conventional tonometer in which the measurement result varies depending on the operator. Able to know.

Although the present invention has been described with reference to the embodiments shown in the drawings, this is merely exemplary, and it will be understood by those skilled in the art that various modifications and equivalent other embodiments are possible. Therefore, the true technical protection scope of the present invention will be defined by the technical spirit of the appended claims.

According to the present invention, it is possible to manufacture a smart contact lens that can easily detect a small strain caused by a change in intraocular pressure.

Claims

An elastic substrate formed of a contact lens material;

An antenna coil embedded in the stretchable substrate, formed of a metal nanomaterial, and spaced apart from each other and formed in a spiral shape, wirelessly receiving power from the outside and performing electromagnetic resonance to wirelessly transmit a signal to the outside;

A rigid body part embedded in the flexible substrate and formed in a circular arc shape having a predetermined length and a rigid body material at a predetermined distance radially spaced apart from the outer circumference of the antenna coil, and positioned between an end portion of the rigid body part; And a soft part formed of a soft material having a modulus different from the rigid material by a predetermined value or more;

The resistance wire is arranged long along the circumferential direction in the soft part so that the strain according to the intraocular pressure, and the terminal is disposed in the rigid part, the sensitivity is adjusted according to the ratio of the circumferential length of the rigid part and the circumferential length of the soft part. A strain sensor;

A sensor connection electrode provided on the rigid body and connected to the strain sensor;

Antenna connection electrodes connected to both ends of the antenna coil;

A wireless communication chip for transmitting the information measured by the strain sensor to the outside through a wireless communication method;

And a stretchable interconnect formed by three-dimensional printing of liquid metal to connect the chip for wireless communication with the sensor connection electrode and to connect the other side of the chip for wireless communication with the antenna connection electrode.
An elastic substrate formed of a contact lens material;

An antenna embedded in the flexible substrate, formed of silver nanofibers and silver nanowires, and both ends thereof are spaced apart from each other and formed in a spiral shape to wirelessly receive power from the outside and perform electromagnetic resonance to wirelessly transmit a signal to the outside; A coil;

A rigid body part embedded in the flexible substrate and formed in an arc shape having a preset length and formed of epoxy at a position spaced apart from the outer circumference of the antenna coil in a radial direction by a predetermined distance, and positioned between an end portion of the rigid body part and formed of silicon; A hybrid substrate comprising a soft portion;

The resistance wire is arranged long along the circumferential direction in the soft part so that the strain according to the intraocular pressure, and the terminal is disposed in the rigid part, the sensitivity is adjusted according to the ratio of the circumferential length of the rigid part and the circumferential length of the soft part. A strain sensor formed of silicon;

A sensor connection electrode provided on the rigid body and connected to the strain sensor;

Antenna connection electrodes connected to both ends of the antenna coil;

An NFC chip transmitting the information measured by the strain sensor to the outside through a short range wireless communication method;

3. A smart contact lens for intraocular pressure monitoring, comprising: a flexible interconnect formed by three-dimensional printing of liquid metal to connect the NFC chip to the sensor connection electrode and to connect the other side of the NFC chip to the antenna connection electrode.
The method according to claim 1,

The rigid body portion is formed in a circular arc shape and a plurality of the spaced apart from each other by a predetermined interval,

The soft part may be an intraocular pressure monitoring smart contact lens formed in an arc shape between two adjacent rigid parts of the plurality of rigid parts.
The method according to claim 1,

The circumferential length of the rigid body portion is a smart contact lens for intraocular pressure monitoring is set to 3 to 10 times the circumferential length of the soft portion.
The method according to claim 1,

The rigid material comprises an epoxy,

The soft material comprises a silicon smart contact lens for pressure monitoring.
The method according to claim 1,

The antenna coil,

A smart contact lens for intraocular pressure monitoring, comprising at least one of a one-dimensional metal nanomaterial and a two-dimensional metal nanomaterial.
The method according to claim 1,

The strain sensor,

Smart contact lenses for intraocular pressure monitoring, including silicon nanomembrane-based sensors.
Applying a sacrificial layer on the mother substrate;

Transferring a strain sensor on the sacrificial layer to detect strain due to intraocular pressure;

Depositing and patterning an electrode material to form a sensor connection electrode connected to a terminal of the strain sensor and an antenna connection electrode to be connected to an antenna coil;

After coating a metal nano material to form a metal nano material layer, patterning the metal nano material layer in a spiral antenna pattern, the antenna for wirelessly receiving power from the outside and performing electromagnetic resonance to wirelessly transmit a signal to the outside Forming a coil;

Coating a first stretchable material on the antenna coil to form a passivation layer, and forming a via hole to expose the strain sensor, the sensor connection electrode, and the antenna connection electrode;

After the rigid material is coated to form a rigid layer, the sensor connection electrode is covered at a predetermined distance radially spaced from the outer circumference of the antenna coil, and the resistance wire of the strain sensor is formed in an arc shape of a preset length. Patterning to form a rigid portion;

Coating a soft material having a modulus different from the rigid material by a predetermined value or more on the rigid part to form a hybrid substrate including a soft part covering the strain sensor between ends of the rigid part;

Forming a chip for wireless communication transmitting the information measured by the strain sensor to the outside through a wireless communication method;

3D printing a liquid metal in a predetermined pattern, connecting the one side of the wireless communication chip and the sensor connection electrode, and forming a stretchable interconnect connecting the other side of the wireless communication chip and the antenna connection electrode;

Coating a second stretchable material to form a stretchable package protecting the antenna coil, the stretchable interconnect, the strain sensor and the chip for wireless communication;

Removing the sacrificial layer;

The manufacturing method of the smart contact lens for intraocular pressure monitoring comprising the step of manufacturing the elastic package in the shape of a contact lens.
The method according to claim 8,

The circumferential length of the rigid body portion is set to 3 to 10 times the circumferential length of the soft portion is patterned manufacturing method of the smart contact lens for intraocular pressure monitoring.
The method according to claim 8,

The rigid material includes an epoxy,

The elastic material is a method of manufacturing a smart contact lens for intraocular pressure monitoring containing silicon.
The method according to claim 8,

Forming the hybrid substrate,

The method of manufacturing a smart contact lens for intraocular pressure monitoring is formed by coating the soft material to cover both the passivation layer and the rigid part.
The method according to claim 8,

Producing the shape of the contact lens,

A method of manufacturing a smart contact lens for intraocular pressure monitoring in which a contact lens material and the stretchable package are placed in a concave formed lower mold for a lens, and pressed with a convex upper mold for a lens.