WO2019226870A1 - Systèmes de stockage internes pour dispositifs médicaux intracorporels miniaturisés pouvant être commandés - Google Patents

Systèmes de stockage internes pour dispositifs médicaux intracorporels miniaturisés pouvant être commandés Download PDF

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Publication number
WO2019226870A1
WO2019226870A1 PCT/US2019/033700 US2019033700W WO2019226870A1 WO 2019226870 A1 WO2019226870 A1 WO 2019226870A1 US 2019033700 W US2019033700 W US 2019033700W WO 2019226870 A1 WO2019226870 A1 WO 2019226870A1
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WO
WIPO (PCT)
Prior art keywords
internal storage
medical device
miniaturized
intra
medical
Prior art date
Application number
PCT/US2019/033700
Other languages
English (en)
Inventor
Christopher J.P. Velis
Matthew P. Palmer
Original Assignee
Velis Christopher J P
Palmer Matthew P
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Velis Christopher J P, Palmer Matthew P filed Critical Velis Christopher J P
Publication of WO2019226870A1 publication Critical patent/WO2019226870A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/041—Capsule endoscopes for imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00064—Constructional details of the endoscope body
    • A61B1/0011—Manufacturing of endoscope parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/04—Endoscopic instruments

Definitions

  • the present invention relates generally to internal storage systems for a miniaturized intra-body controllable medical device.
  • the intra-body medical device may have a propulsion system, a deployment system, a control system, a power supply system, an imaging system, a therapy system, a sample and data gathering system, and/or a material dispensing system.
  • the devices may work independently or work together in a group.
  • the invention details materials and methods for using an intra-body controllable medical device with internal storage systems.
  • Natural orifices include the nostrils, mouth, ear canals, nasolacrimal ducts, anus, urinary meatus, vagina, and nipples.
  • the lumens include the interior of the gastrointestinal tract, the pathways of the bronchi in the lungs, the interior of the renal tubules and urinary collecting ducts, the pathways of the vagina, uterus, and fallopian tubes. From within these orifices and lumens, physicians can create an incision to gain access to almost any region of the body.
  • Laparoscopic procedures allow the physician to use a small“key-hole” surgical opening and specially designed instruments to gain access to regions within the body. Initially, laparoscopic instruments were linear in nature, and required a straight obstruction free“line-of-sight” to access regions of the body. Endoscopic procedures allow the physician to access regions of the digestive system by passing flexible instruments through either the mouth or rectum.
  • pill capsules have been invented that allow for a patient to ingest the capsule and as it passes through the digestive system takes pictures. There are no means for: controlling the motion of these devices, tracking or controlling the orientation, speed or location of these devices, accurately knowing where pictures were taken, and performing any type of surgical procedure or delivering therapy.
  • the medical device for intra-body conveyance that has internal storage systems therein.
  • the medical device includes a host structure defining an interior area and one or more internal storage systems located in the interior area.
  • the internal storage systems include one or more miniaturized compartments.
  • the host structure has a diameter D of about 25mm and a length L of about 75mm.
  • one or more of the miniaturized compartments are configured for housing a power supply, an energy storage device, a medication, an imaging system, a computer processor controller, a communications transmitters or receiver, a propulsion system, a therapy delivering device, a process waste, a biopsy sample, a blood or tissue samples, a medical or surgical instrument, a fluid, a gas, a powder, and/or a consumable material.
  • the host structure includes a clinically inert material, a sterilizable material, an elastomeric material, a chemically reactive material, a chemically inert material, a disintegrable material, a dissolvable material, a collapsible material and/or a material having physical and chemical properties to withstand exposure to bodily fluids for a predetermined period of time.
  • a method for using any of the medical devices having one or more internal storage systems is directed to use in a gastro/intestinal tract, use in urology applications, use in a lung, use in a bladder, use in a nasal system, use in a reproductive system, use in performing
  • TURBT Transurethral Resection of Bladder Tumors
  • TURP Transurethral Resection of the Prostate
  • trans rectal prostate ultrasound, biopsy, and/or radiation treatment use in trans rectal prostate ultrasound, biopsy, and/or radiation treatment.
  • a method for treating a patient, utilizing a medical device for intra-body conveyance having one or more internal storage systems is disclosed.
  • the medical device includes a host structure defining an interior area and one or more internal storage system located in the interior area.
  • the internal storage systems include one or more miniaturized compartments.
  • the miniaturized compartments are configured for housing a power supply, an energy storage device, a medication, an imaging system, a computer processor controller, a communications transmitters or receiver, a propulsion system, a therapy delivering device, a process waste, a biopsy sample, a blood or tissue samples, a medical or surgical instrument, a fluid, a gas, a powder, and/or a consumable material.
  • the host structure includes a clinically inert material, a sterilizable material, an elastomeric material, a chemically reactive material, a chemically inert material, a disintegrable material, a dissolvable material, a collapsible material and/or a material having physical and chemical properties to withstand exposure to bodily fluids for a
  • FIG. 1 illustrates a representative intra-body controllable medical device formed in accordance with the present invention
  • FIG. 2 illustrates an alternative representation of an intra-body controllable medical device formed in accordance with the present invention
  • FIG. 3 illustrates one embodiment of an internal storage system for intra-body controllable medical devices in accordance with the present invention.
  • FIG. 1 illustrates an exemplary intra-body controllable medical device (hereinafter “the medical devices”).
  • the intra-body controllable medical device 5 is capsule shaped.
  • the intra-body controllable medical device 5 has a distal end 10, a proximal end 15, and a body 20 connecting the distal end 10 and proximal end 15.
  • An internal storage system is located within the body 20 of the medical device 5, as described herein.
  • a control unit, a power supply system, an imaging system, a therapy system, a sample and data gathering system, and a material dispensing system is located within the body 20 of the medical device 5, as described herein.
  • the intra-body controllable medical device 5 may be sized according to the anatomy that it will need to navigate, and the method used to deliver it.
  • overall dimensions for an intra-body controllable device operating within the gastrointestinal track may have a diameter D of about 25mm and a length L of about 75mm. More preferably, the device may have a diameter D of about 15 mm and a length L of about 50mm. Most preferably, the diameter D is less than about l5mm and a length L of less than about 50mm.
  • Overall dimensions for an intra-body controllable device that is delivered using a scope may have a diameter D of about 20mm in diameter D and a length L of about 75mm.
  • the diameter D is about l5mm and the length L is about 50mm. Most preferably, the diameter D is less than l5mm and the length L less than 50mm. Control systems, power supply systems, internal storage systems, imaging systems, therapy systems, sample and data gathering systems, and material dispensing systems are sized to fit within these dimensional guidelines.
  • the intra-body controllable medical device 5 is octopus shaped.
  • the intra-body controllable medical device has a main body 30, and appendages 35. Appendages 35 are used for propulsion, covering or wrapping the host structure 20, forming a portion of the host structure 20 or to perform a therapeutic or diagnostic task.
  • An internal storage system 200 is located within main body 30 and/or appendages 35 of the device or in the interior areas 22 of the host structure.
  • control unit power supply systems, an imaging system, a therapy system, a sample and data gathering system, and a material dispensing system is located within main body 30 and/or appendages 35 of the device or in the interior areas 22 of the host structure or in one or more of the internal storage systems 200.
  • the present invention is generally directed to an intra-body medical device having internal storage systems 200, 200’ therein.
  • the internal storage system 200 is shown and marked with five miniaturized compartments A, B, C, D and E for housing one or more power supplies, energy storage devices, medications, imaging systems, computer processor controllers, communications transmitters and receivers, propulsion systems, therapy delivering devices (e.g., radiation sources), process waste, biopsies, blood and tissue samples, medical and surgical instruments, fluids, gases, powders and consumables, generally designated by element number 210.
  • the internal storage systems 200, 200’ and miniaturized compartments A, B, C, D and E are sized to fit within the body 20 and are therefore of smaller length and diameter than the length L and diameter D of the body 20.
  • the miniaturized compartments A, B, C, D and E of the internal storage system 200 are shown removably connected to one another in series.
  • a channel or conduit 202 provides an interconnection and
  • the internal storage system 200 is shown secured to the body 20 at the miniaturized compartment E by supports or tethers 203.
  • the miniaturized compartment B is shown in communication with a conduit 204 which extends through an opening or port 201 which is configured to be selectively opened, closed or throttled by a suitable valve, door, screen or the like to transmit fluids, therapy and imaging components, tissue and medication therethrough.
  • the body 20 includes another opening 206 that is also configured to be selectively opened, closed or throttled by a suitable valve, door, screen 205 for receiving or discharging (e.g., in the general direction of the arrow X) one or more of the miniaturized compartments A, B, C, D and E, as shown, for example, by dashed lines for miniaturized compartment C’.
  • a suitable valve, door, screen 205 for receiving or discharging (e.g., in the general direction of the arrow X) one or more of the miniaturized compartments A, B, C, D and E, as shown, for example, by dashed lines for miniaturized compartment C’.
  • the internal storage system 200’ is secured to an internal wall of the body 20 and includes openings or ports 201’ which are configured to be selectively opened, closed or throttled by a suitable valve, door, screen or the like to transmit fluids, therapy and imaging components, tissue and medication therethrough.
  • each of the internal storage systems 200 and 200’ are shown and described having 5 miniaturized compartments, the present invention is not limited in this regard as less than 5 or more than 5 miniaturized compartments may be employed in each of the internal storage systems 200 and 200’.
  • the internal storage system 200 is shown and described as being secured to the body 20 at the miniaturized compartment E by supports or tethers 203, the present invention is not limited in this regard as the internal storage system 200 may be secured directly to or be integral with the body 20 or may be secured to the body 20 or other portions of the medical device 5 at one or more of the miniaturized compartment A, B, C, D and E.
  • the storage compartments A, B, C, D and E configured with walls, internal and external support structures, inlets, outlets, sensors (e.g., temperature, pressure and chemistry sensors), valves, pumps and ingress/egress apertures.
  • the internal storage system 200 is used to hold nerve blocking and stimulating drugs and devices, may hold devices for cleaning plaque from artery walls or may hold and deploy intestinal restrictive bands.
  • the present invention includes materials for manufacture of an intra-body controllable medical devices 5 and the internal storage systems 200, 200’, and in particular to materials that are clinically inert, sterilizable, elastomeric (e.g., contractible and expandable), chemically reactive, chemically inert, dissolvable, collapsible and have physical and chemical properties to withstand exposure to bodily fluids for precise predetermined periods of time.
  • materials include polymers, metallic alloys, shape memory polymers, shape memory metal alloys, shape memory ceramics, composites, silicones, thermoplastic polyurethane-based materials, excipients, zeolite adsorbents and styrene-butadiene rubbers (SBR).
  • Materials may further include biodegradable materials such as paper, starches, biodegradable material such as gelatin or collagen.
  • the intra-body controllable medical devices 5 and internal storage devices 200, 200’ may be disposable, disintegrable and selectively collapsible intra-body controllable medical devices and materials and structures thereof.
  • the intra-body controllable medical devices 5 and/or the internal storage devices 200, 200’ are manufactured of one or more materials such as an elastomer (e.g., nitrile) that can expand and contract, for example, by inflating and deflating them.
  • the intra-body controllable medical devices and/or and the internal storage devices 200, 200’ are manufactured from a biodegradable, disintegrable or dissolvable material, including paper, starches, biodegradable material such as gelatin or collagen and/or synthetic natural polymers.
  • the collapsible intra-body controllable medical devices 5 along with the internal storage devices 200, 200’ are configured to be flattened, extruded, stretched or disassembled in the lumen.
  • the intra-body controllable medical devices 5 with the internal storage devices 200, 200’ therein are disposed of in the lumen or via discharge therefrom without the need to recover the intra-body controllable medical devices for analysis, inspection or future use.
  • the present invention is directed to methods for using intra-body controllable medical devices 5 with the internal storage devices 200, 200’ therein in the medical field and in particular for use in administering medications and therapy, deploying medical devices, imaging, and surgery.
  • the methods for using intra-body controllable medical devices 5 with the internal storage devices 200, 200’ therein includes applications in the gastro/intestinal tract (e.g.
  • the methods for using intrabody controllable medical devices include use in procedural

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Optics & Photonics (AREA)
  • Manufacturing & Machinery (AREA)
  • Endoscopes (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Surgical Instruments (AREA)

Abstract

La présente invention concerne un dispositif médical comprenant une structure hôte qui présente une surface interne et un ou plusieurs systèmes de stockage internes qui présentent un ou plusieurs compartiments miniaturisés pour loger une ou plusieurs sources d'énergie, dispositifs de stockage d'énergie, médicaments, systèmes d'imagerie, dispositifs de commande par processeur informatique, transmetteurs et récepteurs de communications, systèmes de propulsion, dispositifs d'administration de thérapie (par exemple, sources de rayonnement), déchets de traitement, biopsies, prélèvements de sang et de tissu, instruments médicaux et chirurgicaux, liquides, gaz, poudres et consommables.
PCT/US2019/033700 2018-05-24 2019-05-23 Systèmes de stockage internes pour dispositifs médicaux intracorporels miniaturisés pouvant être commandés WO2019226870A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862675938P 2018-05-24 2018-05-24
US62/675,938 2018-05-24

Publications (1)

Publication Number Publication Date
WO2019226870A1 true WO2019226870A1 (fr) 2019-11-28

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PCT/US2019/033700 WO2019226870A1 (fr) 2018-05-24 2019-05-23 Systèmes de stockage internes pour dispositifs médicaux intracorporels miniaturisés pouvant être commandés

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Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5984860A (en) * 1998-03-25 1999-11-16 Shan; Yansong Pass-through duodenal enteroscopic device
US20030060702A1 (en) * 2001-08-29 2003-03-27 Rainer Kuth Minimally invasive medical system employing a magnetically controlled endo-robot
WO2006045011A2 (fr) * 2004-10-20 2006-04-27 The Board Of Trustees Of The Leland Stanford Junior University Endocapsule
US20080194912A1 (en) * 2005-01-18 2008-08-14 Koninklijke Philips Electronics, N.V. Electronically Controlled Ingestible Capsule for Sampling Fluids in Alimentary Tract
US20090182197A1 (en) * 2005-08-01 2009-07-16 G.I. View Ltd. Tools for use in small intestine
US20170209029A1 (en) * 1999-03-01 2017-07-27 West View Research, Llc Computerized information collection and processing apparatus
US20170265807A1 (en) * 2016-02-01 2017-09-21 Megan Stopek Systems and methods for fetal monitoring
US20180049725A1 (en) * 2016-08-18 2018-02-22 Progenity Inc. Systems and methods for obtaining samples using ingestible devices

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5984860A (en) * 1998-03-25 1999-11-16 Shan; Yansong Pass-through duodenal enteroscopic device
US20170209029A1 (en) * 1999-03-01 2017-07-27 West View Research, Llc Computerized information collection and processing apparatus
US20030060702A1 (en) * 2001-08-29 2003-03-27 Rainer Kuth Minimally invasive medical system employing a magnetically controlled endo-robot
WO2006045011A2 (fr) * 2004-10-20 2006-04-27 The Board Of Trustees Of The Leland Stanford Junior University Endocapsule
US20080194912A1 (en) * 2005-01-18 2008-08-14 Koninklijke Philips Electronics, N.V. Electronically Controlled Ingestible Capsule for Sampling Fluids in Alimentary Tract
US20090182197A1 (en) * 2005-08-01 2009-07-16 G.I. View Ltd. Tools for use in small intestine
US20170265807A1 (en) * 2016-02-01 2017-09-21 Megan Stopek Systems and methods for fetal monitoring
US20180049725A1 (en) * 2016-08-18 2018-02-22 Progenity Inc. Systems and methods for obtaining samples using ingestible devices

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