WO2019222459A1 - Préparations de cannabinoïdes et utilisations thérapeutiques - Google Patents

Préparations de cannabinoïdes et utilisations thérapeutiques Download PDF

Info

Publication number
WO2019222459A1
WO2019222459A1 PCT/US2019/032603 US2019032603W WO2019222459A1 WO 2019222459 A1 WO2019222459 A1 WO 2019222459A1 US 2019032603 W US2019032603 W US 2019032603W WO 2019222459 A1 WO2019222459 A1 WO 2019222459A1
Authority
WO
WIPO (PCT)
Prior art keywords
cancer
cannabinoid
preparation
pharmaceutical composition
cbd
Prior art date
Application number
PCT/US2019/032603
Other languages
English (en)
Inventor
William Fisher
Sarah KATTA
Philip ARLEN
Original Assignee
Diverse Biotech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diverse Biotech, Inc. filed Critical Diverse Biotech, Inc.
Publication of WO2019222459A1 publication Critical patent/WO2019222459A1/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia

Definitions

  • a patient receiving treatment for glioblastoma does not have one or more of the following:
  • the pharmaceutical composition administered in conjunction with any of the additional therapies described above contains 100 mg/ml of the cannabinoid preparation. In some embodiments, a daily dose of 200 mg of the cannabinoid preparation is administered. In some embodiments, a first sublingual dose of 100 mg is administered in the morning, before the first meal of the day, and a second sublingual dose of 100 mg of the cannabinoid preparation is administered before the evening meal. In some embodiments, the pharmaceutical composition is administered throughout the period the patient is receiving the additional therapy. In some embodiments, continued administration of the pharmaceutical composition is recommended once the additional therapy is completed ( e.g ., at a daily dose of 10, 20, 25, 30, 35, 40, or 50 mg/ml of the cannabinoid preparation).
  • plasma concentrations of CBD, its two major metabolites 7-hydroxy-cannabidiol (7-OH-CBD) and 7-carboxy-cannabidiol (7-COOH- CBD), and the minor metabolite 6-hydroxy-cannabidiol (6-OH-CBD) can be measured using methods well known in the art. See , e.g., Ujvary & Hanus, 2016).
  • Therapeutic levels of various chemotherapeutic drugs e.g, TMZ and its active metabolite 3-methyl-(triazen-l-yl)imidazole-4-carboxamide (MTIC) in patients being treated for glioblastoma
  • TMZ TMZ and its active metabolite 3-methyl-(triazen-l-yl)imidazole-4-carboxamide (MTIC) in patients being treated for glioblastoma
  • MTIC 3-methyl-(triazen-l-yl)imidazole-4-carboxamide
  • PFS progression-free survival
  • PFS is determined using only radiographic methods.
  • the crude extract was dewaxed using a solvent-assisted precipitation and filtration step to provide a refined extract, which was then placed in a stainless steel crystallization tank. After 24- 48 hours, the crystals were washed several times, dried, and ground, resulting in a crystalline cannabinoid preparation in which 99.8% by weight was CBD.
  • Example 1 The cannabinoid preparation obtained in Example 1 was formulated in hempseed oil and analyzed for plant-based cannabinoids by convergence chromatography. The data collected were compared to data collected for certified reference standards at known concentrations. Table 1.
  • Max THC (and Max CBD) were calculated values for total cannabinoids after heating, assuming complete decarboxylation of the acid to the neutral form, i.e., the values were calculated based on the weight loss of the acid group during decarboxylation.
  • Max THC (0.877 x THCA) + THC.
  • ND None detected above the limits of detection.
  • BRCX014 composition prepared according to Example 2
  • SOC standard of care
  • CR Complete Response
  • Partial Response At least a 30% decrease in the sum of diameters of target lesions, taking as reference the baseline sum diameters.
  • PD Progressive Disease
  • SD Stable Disease
  • lymph nodes All lymph nodes must be non-pathological in size ( ⁇ l0mm short axis).
  • Non-CR/Non-PD Persistence of one or more non-target lesion(s) and/or
  • the appearance of one or more new lesions is also considered progression.
  • Crippa et al. “Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report,” J. Psychopharmacol. 25, 121-30, 2011
  • Devinsky et al. “Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome,”
  • Hottinger et al. “Tumor treating fields: a novel treatment modality and its use in brain tumors,” Neuro-Oncol. 18, 1338-49, 2016
  • TRPV1 transient receptor potential vanilloid 1

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne des préparations de cannabinoïdes dans lesquelles au moins 99 % en poids de la préparation est le cannabidiol (CBD). L'invention concerne également des compositions pharmaceutiques contenant les préparations de cannabinoïdes et des procédés d'utilisation des compositions pharmaceutiques dans le traitement du cancer.
PCT/US2019/032603 2018-05-18 2019-05-16 Préparations de cannabinoïdes et utilisations thérapeutiques WO2019222459A1 (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201862673550P 2018-05-18 2018-05-18
US62/673,550 2018-05-18
US201862764775P 2018-08-16 2018-08-16
US62/764,775 2018-08-16
US201862721414P 2018-08-22 2018-08-22
US62/721,414 2018-08-22
US201862735908P 2018-09-25 2018-09-25
US62/735,908 2018-09-25

Publications (1)

Publication Number Publication Date
WO2019222459A1 true WO2019222459A1 (fr) 2019-11-21

Family

ID=66677258

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2019/032603 WO2019222459A1 (fr) 2018-05-18 2019-05-16 Préparations de cannabinoïdes et utilisations thérapeutiques

Country Status (1)

Country Link
WO (1) WO2019222459A1 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112569213A (zh) * 2020-12-30 2021-03-30 中国医学科学院医学生物学研究所 大麻二酚在制备治疗急性b淋巴细胞白血病的药物中的应用
EP3861992A1 (fr) * 2020-02-07 2021-08-11 Brio Ventures, LLC Thérapie combinée comprenant des composés dérivés de plantes et des composés antinéoplastiques pour le traitement de malignités hématologiques
WO2021219903A1 (fr) * 2020-04-29 2021-11-04 Emerald Health Biotechnology España S.L. Cannabinoïdes destinés à être utilisés dans la suppression de cellules souches cancéreuses
WO2023056303A1 (fr) * 2021-09-28 2023-04-06 Gbs Global Biopharma, Inc. Formulations contenant des cannabinoïdes pour des troubles du mouvement parkinsoniens
US11660348B1 (en) 2022-02-01 2023-05-30 Akos Biosciences, Inc. Cannabinoid conjugate molecules
US11883499B2 (en) 2022-02-01 2024-01-30 Akos Biosciences, Inc. Cannabinoid conjugate molecules
WO2024058551A1 (fr) * 2022-09-14 2024-03-21 주식회사 네오켄바이오 Composition pharmaceutique pour le traitement du cancer du foie comprenant du cannabidiol et un agent anticancéreux en tant que principes actifs et son utilisation
WO2024091989A1 (fr) * 2022-10-26 2024-05-02 Ecofibre USA Inc. Compositions stabilisées comprenant du cannabidiol
US11975036B2 (en) 2021-10-26 2024-05-07 Ecofibre USA Inc. Methods of treating ovarian cancer with hemp extract
US11986505B2 (en) 2021-10-26 2024-05-21 Ecofibre USA Inc. Methods of treating endometriosis and other noncancer gynecological disorders with hemp extract

Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030166727A1 (en) * 2000-06-16 2003-09-04 Raphael Mechoulam Pharmaceutical compositions comprising cannabidiol derivatives
US20060167283A1 (en) * 2002-09-23 2006-07-27 Ian Flockhart Method of preparing cannabidiol from plant material
US20100249223A1 (en) * 2007-04-19 2010-09-30 Gw Pharma Limited New use for cannabinoid-containing plant extracts
US20100298579A1 (en) 2009-04-29 2010-11-25 Thc Pharm Gmbh Process for preparing synthetic cannabinoids
US20140314757A1 (en) * 2011-10-18 2014-10-23 Gw Pharma Limited Phytocannabinoids for use in the treatment of breast cancer
WO2014202989A1 (fr) * 2013-06-19 2014-12-24 Gw Pharma Limited Utilisation de tetrahydrocannabinol et/ou de cannabidiol pour augmenter la radiosensibilité dans le traitement d'une tumeur cérébrale
US20170022132A1 (en) 2014-07-02 2017-01-26 Cv Sciences, Inc. Novel process for generating hemp oil with a high cannabidiol (cbd) content
US20170051231A1 (en) 2015-08-21 2017-02-23 Hydro Dynamics, Inc. Method of Extracting CBD, THC, and other Compounds from Cannabis using Controlled Cavitation
WO2017204986A1 (fr) * 2016-05-27 2017-11-30 Insys Development Company, Inc. Formulations de cannabinoïdes stables
US20170349518A1 (en) * 2016-06-01 2017-12-07 Daniel Dickman Crystalline Form of Cannabidiol
US20170360861A1 (en) 2014-12-12 2017-12-21 Green Sky Labs, Inc. Methods for extracting target compounds from cannabis
US20180000879A1 (en) * 2015-01-22 2018-01-04 Phytoplant Research S.L. Methods of Purifying Cannabinoids, Compositions and Kits Thereof
WO2018011808A1 (fr) * 2016-07-14 2018-01-18 Icdpharma Ltd Compositions auto-émulsifiantes de cannabinoïdes
US20180064055A1 (en) 2013-03-15 2018-03-08 Biotech Institute LLC Extracts of cbd and thc
US20180133272A1 (en) * 2016-11-14 2018-05-17 Farm To Farma, Inc. Cannabinoid formulations and method of making the same

Patent Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030166727A1 (en) * 2000-06-16 2003-09-04 Raphael Mechoulam Pharmaceutical compositions comprising cannabidiol derivatives
US20060167283A1 (en) * 2002-09-23 2006-07-27 Ian Flockhart Method of preparing cannabidiol from plant material
US20100249223A1 (en) * 2007-04-19 2010-09-30 Gw Pharma Limited New use for cannabinoid-containing plant extracts
US20100298579A1 (en) 2009-04-29 2010-11-25 Thc Pharm Gmbh Process for preparing synthetic cannabinoids
US20140314757A1 (en) * 2011-10-18 2014-10-23 Gw Pharma Limited Phytocannabinoids for use in the treatment of breast cancer
US20180064055A1 (en) 2013-03-15 2018-03-08 Biotech Institute LLC Extracts of cbd and thc
WO2014202989A1 (fr) * 2013-06-19 2014-12-24 Gw Pharma Limited Utilisation de tetrahydrocannabinol et/ou de cannabidiol pour augmenter la radiosensibilité dans le traitement d'une tumeur cérébrale
US20170022132A1 (en) 2014-07-02 2017-01-26 Cv Sciences, Inc. Novel process for generating hemp oil with a high cannabidiol (cbd) content
US20170360861A1 (en) 2014-12-12 2017-12-21 Green Sky Labs, Inc. Methods for extracting target compounds from cannabis
US20180000879A1 (en) * 2015-01-22 2018-01-04 Phytoplant Research S.L. Methods of Purifying Cannabinoids, Compositions and Kits Thereof
US20170051231A1 (en) 2015-08-21 2017-02-23 Hydro Dynamics, Inc. Method of Extracting CBD, THC, and other Compounds from Cannabis using Controlled Cavitation
WO2017204986A1 (fr) * 2016-05-27 2017-11-30 Insys Development Company, Inc. Formulations de cannabinoïdes stables
US20170349518A1 (en) * 2016-06-01 2017-12-07 Daniel Dickman Crystalline Form of Cannabidiol
WO2018011808A1 (fr) * 2016-07-14 2018-01-18 Icdpharma Ltd Compositions auto-émulsifiantes de cannabinoïdes
US20180133272A1 (en) * 2016-11-14 2018-05-17 Farm To Farma, Inc. Cannabinoid formulations and method of making the same

Non-Patent Citations (98)

* Cited by examiner, † Cited by third party
Title
A. SHRIVASTAVA ET AL: "Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy", MOLECULAR CANCER THERAPEUTICS, vol. 10, no. 7, 12 May 2011 (2011-05-12), US, pages 1161 - 1172, XP055418898, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-10-1100 *
ABRAMS: "Integrating cannabis into clinical cancer care", CURRENT ONCOLOGY, vol. 23, 2016, pages S8 - S14
ATTAL ET AL.: "Lenalidomide, Bortezomib, and Dexamethasone with Transplantation for Myeloma", N. ENGL. J. MED., vol. 376, 2017, pages 1311 - 20
AVIELLO ET AL.: "Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer", J. MOL. MED., 2012, pages 10
BARBARA ROMANO ET AL: "Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol", PHYTOMEDICINE, vol. 21, no. 5, 1 April 2014 (2014-04-01), AMSTERDAM, NL, pages 631 - 639, XP055605852, ISSN: 0944-7113, DOI: 10.1016/j.phymed.2013.11.006 *
BERGAMASCHI ET AL.: "Safety and Side Effects of Cannabidiol, a Cannabis sativa Constituent", CURRENT DRUG SAFETY, vol. 6, 2011, pages 13
BHATTACHARYYA ET AL.: "Opposite Effects of A-9-Tetraydrocannabinol and Cannbidiol on Human Brain Function and Psychopathology", NEUROPSYCHOPHARMACOLORY, vol. 35, 2010, pages 764 - 74
BLAZQUEZ ET AL.: "Cannabinoids Inhibit the Vascular Endothelial Growth Factor Pathway in Gliomas", CANCER RES., vol. 64, 2004, pages 5617 - 23
BOLOGNINI ET AL.: "Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behavior in rats by enhancing 5-HT1A receptor activation", BR. J. PHARMACOL., vol. 168, 2013, pages 1456 - 70
CAMPOS ET AL.: "Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders", PHIL. TRANS. R. SOC. B, vol. 367, 2012, pages 3364 - 78
CARCHMAN ET AL.: "The inhibition of DNA synthesis by cannabinoids", CANCER RES., vol. 36, 1976, pages 95 - 100, XP000979754
CARLINICUNHA: "Hypnotic and Antiepileptic Effects of Cannabidiol", J. CLIN. PHARMACOL., vol. 21, 1981, pages 417S - 427S
CHAKRAVARTI ET AL.: "Cannabinoids as therapeutic agents in cancer: current status and future impliciations", ONCOTARGET, vol. 5, 2014, pages 5852 - 72, XP055460846, DOI: doi:10.18632/oncotarget.2233
CONROY ET AL.: "FOLFIRINOX versus Gemcitabine for Metastatic pancreatic Cancer", NEW ENGL. J. MED., vol. 364, 2011, pages 1817 - 25, XP002730536, DOI: doi:10.1056/NEJMoa1011923
CRIPPA ET AL.: "Effects of Cannabidiol (CBD) on Regional Cerebral Blood Flow", NEUROPSYCHOPHARMACOLOGY, vol. 29, 2004, pages 417 - 26
CRIPPA ET AL.: "Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report", J. PSYCHOPHARMACOL., vol. 25, 2011, pages 121 - 30
CUNHA ET AL.: "Chronic Administration of Cannabidiol to Healthy Volunteers and Epileptic Patients", PHARMACOL., vol. 21, 1980, pages 175 - 85, XP009139434, DOI: doi:10.1159/000137430
D'ARGENIO ET AL.: "Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation", FASEB J. EXPRESS ARTICLE, 2006, pages 16
DE PETROCELLIS ET AL.: "Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8", J. PHARMACOL. EXP. THER., vol. 325, 2008, pages 1007 - 15
DEL PULGAR ET AL.: "Cannabinoids Protect Astrocytes from Ceramide-induced Apoptosis through the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway", J. BIOL. CHEM., vol. 277, 2002, pages 36527 - 33
DEL PULGAR ET AL.: "De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis", BIOCHEM. J., vol. 363, 2002, pages 183 - 88
DEVINSKY ET AL.: "Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome", NEW ENGL. J. MED., vol. 376, 2017, pages 2011 - 20, XP055581640, DOI: doi:10.1056/NEJMoa1611618
DOLORES HERNÁN PÉREZ DE LA OSSA ET AL: "Local Delivery of Cannabinoid-Loaded Microparticles Inhibits Tumor Growth in a Murine Xenograft Model of Glioblastoma Multiforme", PLOS ONE, vol. 8, no. 1, 22 January 2013 (2013-01-22), pages e54795, XP055512054, DOI: 10.1371/journal.pone.0054795 *
EISENHAUER ET AL.: "New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1", EUR. J. CANCER, vol. 45, 2009, pages 228 - 47, XP025841550, DOI: doi:10.1016/j.ejca.2008.10.026
ELBAZ MOHAMAD ET AL: "Modulation of the tumor microenvironment and inhibition of EGF/EGFR pathway: Novel anti-tumor mechanisms of Cannabidiol in breast cancer", MOLECULAR ONCOLOGY, vol. 9, no. 4, 1 April 2015 (2015-04-01), pages 906 - 919, XP029125030, ISSN: 1574-7891, DOI: 10.1016/J.MOLONC.2014.12.010 *
ENGELS ET AL.: "Medicinal Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel", THE ONCOLOGIST, vol. 12, 2007, pages 291 - 300
FOWLER: "Delta(9)-tetrahydrocannabinol and cannabidiol as potential curative agents for cancer: A critical examination of the preclinical literature", CLIN. PHARMACOL. THER., vol. 97, 2015, pages 587 - 96
FRIEDMAN: "In vivo effects of cannabinoids on macromolecular biosynthesis in Lewis lung carcinomas", CANCER BIOCHEM. BIOPHYS., vol. 2, 1977, pages 51 - 54
FUGH-BERMAN ET AL.: "Medical Cannabis, Adverse Effects & Drug Interactions", GOVERNMENT OF THE DISTRICT OF COLUMBIA DEPARTMENT OF HEALTH SLIDE PRESENTATION, pages 38
FUSAR-POLI ET AL.: "Distinct Effects of A9-Tetrahydrocannabinol and Cannabidiol on Neural Activation During Emotional Processing", ARCH. GEN. PSYCHIATRY, vol. 66, 2009, pages 95 - 105
GABRIELLA AVIELLO ET AL: "Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer", JOURNAL OF MOLECULAR MEDICINE, SPRINGER, BERLIN, DE, vol. 90, no. 8, 10 January 2012 (2012-01-10), pages 925 - 934, XP035084662, ISSN: 1432-1440, DOI: 10.1007/S00109-011-0856-X *
GALVE-ROPERH ET AL.: "Anti-tumoral action of cannbinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation", NATURE MED., vol. 6, 2000, pages 313 - 19
GEFFRETY ET AL.: "Drug-drug interaction between clobazam and cannabidiol in children with refractory epilepsy", EPILEPSIA, vol. 56, 2015, pages 1246 - 51, XP002790755, DOI: doi:10.1111/epi.13060
GREEN ET AL.: "A decreased influence of cannabinoids on macromolecular biosynthesis and cell proliferation in human cells which metabolize polycyclic hydrocarbon carcinogens", ANTICANCER RES., vol. 3, 1983, pages 211 - 17
GUZMAN ET AL.: "A pilot clinical study of A9-tetrahydrocannbinol in patients with recurrent glioblastoma multiforme", BR. J. CANCER, vol. 95, 2006, pages 197 - 203, XP055512051, DOI: doi:10.1038/sj.bjc.6603236
HALLAK ET AL.: "Performance of schizophrenic patients in the Stroop Color Word Test and electrodermal responsiveness after acute administration of cannabidiol (CBD", REVISTA BRASILEIRA DE PSIQUIATRIA, vol. 32, 2010, pages 6
HARVEYMECHOULAM: "Metabolites of cannabidiol identified in human urine", XENOBIOTICA, vol. 20, 1990, pages 303 - 20
HOLLAND ET AL.: "The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells", BIOCHEM. PHARMACOL., vol. 71, 2006, pages 1146 - 54, XP025043237, DOI: doi:10.1016/j.bcp.2005.12.033
HORNBYPROUTY: "Involvement of cannbinoids receptors in gut motility and visceral perception", BR. J. PHARMACOL., vol. 141, 2004, pages 1335 - 45
HOTTINGER ET AL.: "Tumor treating fields: a novel treatment modality and its use in brain tumors", NEURO-ONCOL., vol. 18, 2016, pages 1338 - 49
HOWLET ET AL.: "Regulation of adenylate cyclase by cannabinoid drugs. Insights based on thermodynamic studies", BIOCHEM. PHARMACOL., vol. 38, 1989, pages 3297 - 304, XP023832925, DOI: doi:10.1016/0006-2952(89)90628-X
HOWLETTFLEMING: "Cannabinoid inhibition of adenylate cyclase. Pharmacology of the response in neuroblastoma cell membranes", MOL. PHARMACOL., vol. 26, 1984, pages 532 - 38
HUESTIS: "Human Cannabinoid Pharmacokinetics", CHEM. BIODIVERS., vol. 4, 2007, pages 1770 - 804
HYUNG CHOI ET AL: "Cannabidiol Induces Cytotoxicity and Cell Death via Apoptotic Pathway in Cancer Cell Lines", BIOMOLECULES & THERAPEUTICS, 1 January 2008 (2008-01-01), pages 87 - 94, XP055521538, Retrieved from the Internet <URL:http://www.biomolther.org/journal/view.html?uid=25&vmd=Full> *
IANNOTTI ET AL.: "Nonpsychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability", ACS CHEMICAL NEUROSCIENCE, vol. 5, 2014, pages 1131 - 41
IFFLANDGROTENHERMEN: "An Update on Safety and Side Effects of Cannabidiol: a Review of Clinical Data and Relevant Animal Studies", CANNABIS AND CANNABINOID RESEARCH, vol. 2.1, 2017, pages 16
IVANOV ET AL.: "Regulation of human glioblastoma cell death by combined treatment of cannabidiol, Y-radiation and small molecule inhibitors of cell signaling pathways", ONCOTARGET, vol. 8, 2017, pages 74068 - 95
IZZO ET AL.: "Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb", TRENDS PHARMACOL. SCI., vol. 30, 2009, pages 515 - 27, XP026639899, DOI: doi:10.1016/j.tips.2009.07.006
IZZOCAMILLERI: "Cannabinoids in intestinal inflammation and cancer", PHARMACOL. RES., vol. 60, 2009, pages 117 - 25
JACOBSSON ET AL.: "Serum-dependent effects of tamoxifen and cannabinoids upon C6 glioma cell viability", BIOCHEM. PHARMACOL., vol. 60, 2000, pages 1807 - 13, XP009121672, DOI: doi:10.1016/S0006-2952(00)00492-5
JACOBSSON STIG O P ET AL: "Serum-dependent effects of tamoxifen and cannabinoids upon C6 glioma cell viability", BIOCHEMICAL PHARMACO, ELSEVIER, US, vol. 60, no. 12, 15 December 2000 (2000-12-15), pages 1807 - 1813, XP009121672, ISSN: 0006-2952, [retrieved on 20001130], DOI: 10.1016/S0006-2952(00)00492-5 *
KIMBALL ET AL.: "Agonists of cannabinoid receptor 1 and 2 inhibit experimental colitis induced by oil of mustard and by dextran sulfate sodium", AM. J. PHYSIOL. GASTROINTEST. LIVER PHYSIOL., vol. 291, 2006, pages G364 - G371
KOGAN ET AL.: "A Cannabinoid Quinone Inhibits Angiogenesis by Targeting Vascular Endothelial Cells", MOL. PHARMACOL., vol. 70, 2006, pages 51 - 59
KUMAR ET AL.: "International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma", LANCET ONCOL., vol. 17, 2016, pages e328 - 46, XP029663519, DOI: doi:10.1016/S1470-2045(16)30206-6
LADIN ET AL.: "Preclinical and Clinical Assessment of Cannabinoids as Anti-Cancer Agents", FRONTIERS IN PHARMACOLOGY, vol. 7, no. 361, 2016, pages 18, XP055478492, DOI: doi:10.3389/fphar.2016.00361
LEE: "CBD: How It Works", O'SHAUGHNESSEY'S, 2011, pages 14
LEWEKE ET AL.: "Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia", TRANSL. PSYCHIATRY, vol. 2, 2012, pages e94,7
LIGRESTI A ET AL: "Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, US, vol. 318, no. 3, 1 January 2006 (2006-01-01), pages 1375 - 1387, XP002540820, ISSN: 0022-3565, DOI: 10.1124/JPET.106.105247 *
LIGRESTI ET AL.: "Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma", J. PHARMACOL. EXPERIMENTAL THERAPEUTICS, vol. 318, 2006, pages 1375 - 87, XP002540820, DOI: doi:10.1124/jpet.106.105247
LUCIANO DE PETROCELLIS ET AL: "Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo : pro-apoptotic effects and underlying mechanisms", BRITISH JOURNAL OF PHARMACOLOGY, vol. 168, no. 1, 18 December 2012 (2012-12-18), UK, pages 79 - 102, XP055335428, ISSN: 0007-1188, DOI: 10.1111/j.1476-5381.2012.02027.x *
MADRAS, UPDATE OF CANNABIS AND ITS MEDICAL USE, Retrieved from the Internet <URL:http://www.who.int/medicines/access/controlled-substances/6_2_cannabis_update.pdf>
MANJU SHARMA ET AL: "<i>In Vitro</i> Anticancer Activity of Plant-Derived Cannabidiol on Prostate Cancer Cell Lines", PHARMACOLOGY & PHARMACY, vol. 05, no. 08, 1 January 2014 (2014-01-01), United States, pages 806 - 820, XP055606160, ISSN: 2157-9423, DOI: 10.4236/pp.2014.58091 *
MARIA BEATRICE MORELLI ET AL: "The effects of cannabidiol and its synergism with bortezomib in multiple myeloma cell lines. A role for transient receptor potential vanilloid type-2", INTERNATIONAL JOURNAL OF CANCER, vol. 134, no. 11, 2 December 2013 (2013-12-02), US, pages 2534 - 2546, XP055304213, ISSN: 0020-7136, DOI: 10.1002/ijc.28591 *
MASSA ET AL.: "The endogenous cannabinoid system protects against colonic inflammation", J. CLIN. INVEST., vol. 113, 2004, pages 1202 - 09
MASSI ET AL.: "Cannabidiol as potential anticancer drug", BR. J. CLIN. PHARMACOL., vol. 75, 2012, pages 303 - 12
MASSI P ET AL: "The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells", CELLULAR AND MOLECULAR LIFE SCIENCES, BIRKHÄUSER-VERLAG, BA, vol. 63, no. 17, 10 August 2006 (2006-08-10), pages 2057 - 2066, XP019419223, ISSN: 1420-9071, DOI: 10.1007/S00018-006-6156-X *
MCALLISTER ET AL.: "The antitumor activity of plant-derived non-psychoactive cannabinoids", J. NEUROIMMUNE PHARMACOL., vol. 10, 2015, pages 255 - 67
MCHUGH ET AL.: "Inhibition of Human Neutrophil Chemotaxis by Endogenous Cannabinoids and Phytocannabinoids: Evidence for a Site Distinct from CB 1 and CB2", MOL. PHARMACOL., vol. 73, 2008, pages 441 - 50
MCVEY ET AL.: "Endocannabinoids Induce Ileitis in Rats via the Capsaicin Receptor (VR1", J. PHARMACOL. EXPERIMENTAL THERAPEUTICS, vol. 304, 2003, pages 713 - 22
MECHOULAM ET AL.: "Cannabidiol—recent advances", CHEM. BIODIVERS., vol. 4, 2007, pages 1678 - 92, XP009115726, DOI: doi:10.1002/cbdv.20079014
MEHRZAD ET AL.: "Bevacizumab plus FOLFOX or FOLFIRI regimens on patients with unresectable liver-only metastases of metastatic colorectal cancer", ADV. BIOMED. RES., vol. 5, 2016, pages 11
MOLNAR ET AL.: "Membrane associated antitumor effects of crocine-, ginsenoside- and cannabinoid derivates", ANTICANCER RES., vol. 20, 2000, pages 861 - 67, XP009010607
MORELLI ET AL.: "The effects of cannabidiol and its synergism with bortezomib in multiple myeloma cell lines. A role for transient receptor potential vanilloid type-2", INT. J. CANCER, vol. 134, 2014, pages 2534 - 46, XP055304213, DOI: doi:10.1002/ijc.28591
MUNSON ET AL.: "Antineoplastic activity of cannabinoids", J. NATL. CANCER INST., vol. 55, 1975, pages 597 - 602
MURISON ET AL.: "Cannabinoids induce incomplete maturation of cultured human leukemia cells", PROC. NAT'L. ACAD. SCI. (USA, vol. 84, 1987, pages 5414 - 18, XP002336120, DOI: doi:10.1073/pnas.84.15.5414
NABISSI ET AL.: "Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents", CARCINOGENESIS, vol. 34, 2013, pages 48 - 57
NASSER ET AL.: "Crosstalk between Chemokine Receptor CXCR4 and Cannabinoid Receptor CB2 in Modulating Breast Cancer Growth and Invasion", PLOS ONE, vol. 6, 2011, pages e23901,9
ROCK ET AL.: "Evaluation of the potential of the phytocannabinoids, cannabidivarin (CBDV) and A9-tetrahydrocannabivarin (THCV), to produce CB 1 receptor inverse agonism symptoms of nausea in rats", BR. J. PHARMACOL., vol. 170, 2013, pages 671 - 78, XP055125112, DOI: doi:10.1111/bph.12322
RUH ET AL.: "Failure of cannabinoid compounds to stimulate estrogen receptors", BIOCHEM. PHARMACOL., vol. 53, 1997, pages 35 - 41
SANCHEZ ET AL.: "Inhibition of Glioma Growth in Vivo by Selective Activation of the CB2 Cannabinoid Receptor", CANCER RES., vol. 61, 2001, pages 5784 - 89
SCOTT K A ET AL: "Enhancing the activity of cannabidiol and other cannabinoids in vitro through modifications to drug combinations and treatment schedules", ANTICANCER RESEARCH - INTERNATIONAL JOURNAL OF CANCER RESEARCH AND TREATMENT, INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH, GR, vol. 33, no. 10, 30 September 2013 (2013-09-30), pages 4373 - 4380, XP009504618, ISSN: 0250-7005 *
SHANNONOPILA-LEHMAN: "Effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report", PERM. J., vol. 20, no. 16-005, 2016, pages 4
SHRISTAVA ET AL.: "Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy", MOL. CANCER THERAP., vol. 10, 2011, pages 1161 - 72, XP055418898, DOI: doi:10.1158/1535-7163.MCT-10-1100
SINDISWAT LUKHELE ET AL: "Cannabidiol rather than extracts inhibit cell growth and induce apoptosis in cervical cancer cells", BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, BIOMED CENTRAL LTD, LONDON, UK, vol. 16, no. 1, 1 September 2016 (2016-09-01), pages 1 - 16, XP021267925, DOI: 10.1186/S12906-016-1280-0 *
STONE: "Glutamatergic antipsychotic drugs: a new dawn in the treatment of schizophrenia?", THER. ADV. PSYCHOPHARMACOL., vol. 1, 2011, pages 5 - 18
SZEPSENWOL ET AL.: "Experimentally produced synovial sarcoma in mice", ONCOL., vol. 42, 1985, pages 61 - 67
TAKEDA ET AL.: "Down-regulation of cyclooxygenase-2 (COX-2) by cannabidiolic acid in human breast cancer cells", J. TOXICOLOGICAL SCIENCES, vol. 39, 2014, pages 711 - 16
THOMASCOLEY: "Overcoming Multidrug Resistance in Cancer: An Update on the Clinical Strategy of Inhibiting P-Glycoprotein", CANCER CONTROL, vol. 10, 2003, pages 159 - 65
TORRES ET AL.: "A Combined Preclinical Therapy of Cannabinoids and Temozolomide against Glioma", MOL CANCER THERAPEUTICS, vol. 10, 2011, pages 90 - 103, XP009150445, DOI: doi:10.1158/1535-7163.MCT-10-0688
TORRES SOFIA ET AL: "A Combined Preclinical Therapy of Cannabinoids and Temozolomide against Glioma", MOLECULAR CANCER THERAPEUTICS, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 10, no. 1, 1 January 2011 (2011-01-01), pages 90 - 103, XP009150445, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-10-0688 *
UJVARYHANUS: "Human Metabolites of Cannabidiol: A Review on Their Formation, Biological Activity, and Relevance in Therapy", CANNABIS AND CANNABINOID RESEARCH, vol. 1.1, 2016, pages 90 - 101
UNO ET AL.: "a-Bisabolol Inhibits Invasiveness and Motility in Pancreatic Cancer Through KISS1R Activation", ANTICANCER RES., vol. 36, 2016, pages 583 - 90
VACCANI ET AL.: "Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism", BR. J. PHARMACOL., vol. 144, 2005, pages 1032 - 36, XP002540821, DOI: doi:10.1038/sj.bjp.0706134
VELASCO ET AL.: "Anticancer mechanisms of cannabinoids", CURR. ONCOL., vol. 23, 2016, pages S23 - S32
ZHORNITSKYPOTVIN: "Cannabidiol in Humans—The Quest for Therapeutic Targets", PHARMACEUTICALS, vol. 5, 2012, pages 529 - 52
ZHU ET AL.: "Characterization of P-glycoprotein Inhibition by Major Cannabinoids from marijuana", J. PHARMACOL. EXPERIMENTAL THERAPEUTICS, vol. 317, 2006, pages 850 - 57
ZUARDI ET AL.: "A Critical Review of the Antipsychotic Effects of Cannbidiol: 30 Years of a Translational Investigation", CURR. PHARMACEUTICAL DESIGN, vol. 18, 2012, pages 5131 - 40
ZUARDI: "Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action", REV. BRAS. PSIQUIATR., vol. 30, 2008, pages 271 - 80, XP055267158, DOI: doi:10.1590/S1516-44462008000300015

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3861992A1 (fr) * 2020-02-07 2021-08-11 Brio Ventures, LLC Thérapie combinée comprenant des composés dérivés de plantes et des composés antinéoplastiques pour le traitement de malignités hématologiques
WO2021219903A1 (fr) * 2020-04-29 2021-11-04 Emerald Health Biotechnology España S.L. Cannabinoïdes destinés à être utilisés dans la suppression de cellules souches cancéreuses
US11583506B1 (en) 2020-04-29 2023-02-21 Vivacell Biotechnology España S.L.U. Cannabinoids for use in suppressing cancer stem cells
CN112569213A (zh) * 2020-12-30 2021-03-30 中国医学科学院医学生物学研究所 大麻二酚在制备治疗急性b淋巴细胞白血病的药物中的应用
WO2023056303A1 (fr) * 2021-09-28 2023-04-06 Gbs Global Biopharma, Inc. Formulations contenant des cannabinoïdes pour des troubles du mouvement parkinsoniens
US11975036B2 (en) 2021-10-26 2024-05-07 Ecofibre USA Inc. Methods of treating ovarian cancer with hemp extract
US11986505B2 (en) 2021-10-26 2024-05-21 Ecofibre USA Inc. Methods of treating endometriosis and other noncancer gynecological disorders with hemp extract
US11883499B2 (en) 2022-02-01 2024-01-30 Akos Biosciences, Inc. Cannabinoid conjugate molecules
US11944686B2 (en) 2022-02-01 2024-04-02 Akos Biosciences, Inc. Cannabinoid conjugate molecules
US11660348B1 (en) 2022-02-01 2023-05-30 Akos Biosciences, Inc. Cannabinoid conjugate molecules
WO2024058551A1 (fr) * 2022-09-14 2024-03-21 주식회사 네오켄바이오 Composition pharmaceutique pour le traitement du cancer du foie comprenant du cannabidiol et un agent anticancéreux en tant que principes actifs et son utilisation
WO2024091989A1 (fr) * 2022-10-26 2024-05-02 Ecofibre USA Inc. Compositions stabilisées comprenant du cannabidiol
US12011451B2 (en) 2022-10-26 2024-06-18 Ecofibre USA Inc. Stabilized compositions comprising cannabidiol

Similar Documents

Publication Publication Date Title
WO2019222459A1 (fr) Préparations de cannabinoïdes et utilisations thérapeutiques
Dariš et al. Cannabinoids in cancer treatment: Therapeutic potential and legislation
Velasco et al. The use of cannabinoids as anticancer agents
Galaj et al. Cannabidiol attenuates the rewarding effects of cocaine in rats by CB2, 5-HT1A and TRPV1 receptor mechanisms
Hudson et al. Cannabidiol counteracts the psychotropic side-effects of δ-9-tetrahydrocannabinol in the ventral hippocampus through bidirectional control of erk1–2 phosphorylation
EP2544682B1 (fr) Phytocannabinoïdes utilisés dans le traitement du cancer
Hosking et al. Therapeutic potential of cannabis in pain medicine
Jeong et al. Anti-inflammatory effects of genistein via suppression of the toll-like receptor 4-mediated signaling pathway in lipopolysaccharide-stimulated BV2 microglia
Murase et al. Targeting multiple cannabinoid anti‐tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer
Gazi et al. The dual specificity PI3K/mTOR inhibitor PKI-587 displays efficacy against T-cell acute lymphoblastic leukemia (T-ALL)
Rajendran et al. Myricetin: Versatile plant based flavonoid for cancer treatment by inducing cell cycle arrest and ROS–reliant mitochondria-facilitated apoptosis in A549 lung cancer cells and in silico prediction
Malhotra et al. Therapeutic potential of cannabinoids in combination cancer therapy
Cascio et al. The pharmacology and therapeutic potential of plant cannabinoids
Mamouni et al. A novel flavonoid composition targets androgen receptor signaling and inhibits prostate cancer growth in preclinical models
Li et al. Immunosuppressive activity on the murine immune responses of glycyrol from Glycyrrhiza uralensis via inhibition of calcineurin activity
Boskabady et al. Possible mechanism of inotropic and chronotropic effects of Rosa damascena on isolated guinea pig heart
Kalvala et al. Role of Cannabidiol and Tetrahydrocannabivarin on Paclitaxel-induced neuropathic pain in rodents
Nair et al. Alcohol versus cannabinoids: a review of their opposite neuro-immunomodulatory effects and future therapeutic potentials
Englund et al. Cannabis in the arm: what can we learn from intravenous cannabinoid studies?
Pietrofesa et al. The synthetic lignan secoisolariciresinol diglucoside prevents asbestos‐induced NLRP3 inflammasome activation in murine macrophages
Kyriakou et al. Efficacy of cannabinoids against glioblastoma multiforme: A systematic review
Parolaro et al. Cannabinoids as potential new therapy for the treatment of gliomas
Waissengrin et al. The use of medical cannabis concomitantly with immune checkpoint inhibitors in non-small cell lung cancer: A sigh of relief?
Bimonte et al. Phytocannabinoids in triple negative breast cancer treatment: current knowledge and future insights
Kampa et al. Flavonoids as new regulators of mitochondrial potassium channels: contribution to cardioprotection

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 19727814

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 19727814

Country of ref document: EP

Kind code of ref document: A1