WO2019221645A3 - Effect of balanites aegyptiaca on the regression of liver fibrosis and cirrhosis - Google Patents

Effect of balanites aegyptiaca on the regression of liver fibrosis and cirrhosis Download PDF

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Publication number
WO2019221645A3
WO2019221645A3 PCT/SD2019/000002 SD2019000002W WO2019221645A3 WO 2019221645 A3 WO2019221645 A3 WO 2019221645A3 SD 2019000002 W SD2019000002 W SD 2019000002W WO 2019221645 A3 WO2019221645 A3 WO 2019221645A3
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WO
WIPO (PCT)
Prior art keywords
cirrhosis
effect
regression
liver fibrosis
extract
Prior art date
Application number
PCT/SD2019/000002
Other languages
French (fr)
Other versions
WO2019221645A9 (en
WO2019221645A2 (en
WO2019221645A4 (en
Inventor
Mohamed Osman ABDELMONEM
Osman Abdelmonim ABDELMONIM
Hisham Hassan ABDELWAHAB
Original Assignee
ABDELWAHAB, Hyder
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ABDELWAHAB, Hyder filed Critical ABDELWAHAB, Hyder
Priority to PCT/SD2019/000002 priority Critical patent/WO2019221645A2/en
Publication of WO2019221645A2 publication Critical patent/WO2019221645A2/en
Publication of WO2019221645A3 publication Critical patent/WO2019221645A3/en
Publication of WO2019221645A4 publication Critical patent/WO2019221645A4/en
Publication of WO2019221645A9 publication Critical patent/WO2019221645A9/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Organic Chemistry (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The pilot study we carried on this extract has shown significant response to treatment with Balanites aegyptiaca extract with P value 0,0052. Since the response to treatment has included patients with non-hepatitis related liver cirrhosis the most likely effect of the extract can be attributed to its anti-fibrotic effect. Therefore we claim this to be effective in patients with liver fibrosis, cirrhosis, myocardial fibrosis and lung fibrosis and may be helpful in patients with chronic kidney disease.
PCT/SD2019/000002 2019-03-27 2019-03-27 Effect of balanitis aegyptiaca on the regression of liver fibrosis and cirrhosis WO2019221645A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/SD2019/000002 WO2019221645A2 (en) 2019-03-27 2019-03-27 Effect of balanitis aegyptiaca on the regression of liver fibrosis and cirrhosis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/SD2019/000002 WO2019221645A2 (en) 2019-03-27 2019-03-27 Effect of balanitis aegyptiaca on the regression of liver fibrosis and cirrhosis

Publications (4)

Publication Number Publication Date
WO2019221645A2 WO2019221645A2 (en) 2019-11-21
WO2019221645A3 true WO2019221645A3 (en) 2022-03-03
WO2019221645A4 WO2019221645A4 (en) 2022-03-31
WO2019221645A9 WO2019221645A9 (en) 2022-05-05

Family

ID=68541171

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SD2019/000002 WO2019221645A2 (en) 2019-03-27 2019-03-27 Effect of balanitis aegyptiaca on the regression of liver fibrosis and cirrhosis

Country Status (1)

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WO (1) WO2019221645A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997023234A1 (en) * 1995-12-23 1997-07-03 National Research Council Balanites aegyptiaca method of treatment
WO2001049306A1 (en) * 1999-12-22 2001-07-12 Hamid Osman A Monieum Balanites aegyptiaca extracts for treatment of hiv/aids and leukemia

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997023234A1 (en) * 1995-12-23 1997-07-03 National Research Council Balanites aegyptiaca method of treatment
WO2001049306A1 (en) * 1999-12-22 2001-07-12 Hamid Osman A Monieum Balanites aegyptiaca extracts for treatment of hiv/aids and leukemia

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
AL-THOBAITI SAED A. ET AL: "Hepatoprotective and antioxidant effects of methanolic extracts of Balanites aegyptiaca against streptozotocin-induced liver damage in rats", JOURNAL OF APPLIED SCIENCES RESEARCH, 1 January 2019 (2019-01-01), Amman-Jordan, XP055885922, ISSN: 1819-544X, Retrieved from the Internet <URL:http://www.aensiweb.net/AENSIWEB/jasr/jasr/2019/November/13-27(2).pdf> DOI: 10.22587/jasr.2019.15.6.2 *
BAYOUMY B E ET AL: "Scientific Research & Studies Center-Faculty of Science-Zagazig University-Egypt Biochemistry Letters Protective Effect of Nanjunda Extract and/or Silymarin Against Thioacetamide-induced Hepatic Fibrosis in Rats A R T I C L E I N F O", BIOCHEMISTRY LETTERS, 1 January 2015 (2015-01-01), pages 52 - 60, XP055885589, Retrieved from the Internet <URL:https://blj.journals.ekb.eg/article_63393_b87d3e7b247dad4b522c54a491e9150d.pdf> [retrieved on 20220131] *
ELWALEED E. IBRAHIM ET AL: "Hepatoprotective effect of Balanites aegyptiaca (L.) Delile leaves against carbon tetrachloride-induced hepatic damage in rats", ARABIAN JOURNAL OF MEDICINAL AND AROMATIC PLANTS, 1 March 2016 (2016-03-01), pages 59 - 67, XP055885583, Retrieved from the Internet <URL:https://revues.imist.ma/index.php/AJMAP/article/view/4860> [retrieved on 20220131], DOI: 10.48347/IMIST.PRSM/ajmap-v2i1.4860 *
LOIYE AHMED HASSAN ET AL: "Chemotherapeutic potentials of the stem bark of (L.) Delile: an antiangiogenic, antitumor and antioxidant agent", BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, BIOMED CENTRAL LTD, LONDON, UK, vol. 16, no. 1, 19 October 2016 (2016-10-19), pages 1 - 13, XP021268319, DOI: 10.1186/S12906-016-1369-5 *
MONTASSER AYAT O S ET AL: "Protective effects ofBalanites aegyptiacaextract, Melatonin and Ursodeoxycholic acid against hepatotoxicity induced by Methotrexate in male rats", ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE, HAINAN MEDICAL COLLEGE, SINGAPORE, vol. 10, no. 6, 15 June 2017 (2017-06-15), pages 557 - 565, XP085147596, ISSN: 1995-7645, DOI: 10.1016/J.APJTM.2017.06.003 *
OJO OPEOLU O ET AL: "Hepatoprotective and antioxidant efficacy of aqueous stem bark extracts of Balanites aegyptiaca (Linn.) Delile against acetaminophen induced liver injury in rats", 1 January 2015 (2015-01-01), XP055885596, Retrieved from the Internet <URL:https://wlv.openrepository.com/bitstream/handle/2436/622762/B.%20aegyptica-Ojo%20et%20al-edited-article%20alone%20(1).pdf?sequence=3> [retrieved on 20220131] *
YASSIN ABDELRAHMAN M ET AL: "Induction of Apoptosis in Human Cancer Cells Through Extrinsic and Intrinsic Pathways byBalanites aegyptiacaFurostanol Saponins and Saponin-Coated SilverNanoparticles", APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, HUMANA PRESS INC, NEW YORK, vol. 182, no. 4, 24 February 2017 (2017-02-24), pages 1675 - 1693, XP036288072, ISSN: 0273-2289, [retrieved on 20170224], DOI: 10.1007/S12010-017-2426-3 *

Also Published As

Publication number Publication date
WO2019221645A9 (en) 2022-05-05
WO2019221645A2 (en) 2019-11-21
WO2019221645A4 (en) 2022-03-31

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