WO2019219280A1

WO2019219280A1 - Anhydrous antiperspirant preparation

Info

Publication number: WO2019219280A1
Application number: PCT/EP2019/057530
Authority: WO
Inventors: Benjamin WINTER; Robert Klauck; Frank Lehmbeck; Thomas Raschke
Original assignee: Beiersdorf Ag
Priority date: 2018-05-17
Filing date: 2019-03-26
Publication date: 2019-11-21
Also published as: EP3793693A1; DE102018207690A1

Abstract

The present invention relates to an anhydrous cosmetic preparation comprising at least one alkali metal silicate and at least one organic compound containing an ester group which hydrolyzes at a pH value of 7.5 to 12.

Description

Anhydrous antiperspirant active preparation

The present invention relates to an anhydrous cosmetic preparation containing at least one silicate of alkali metals, preferably of sodium and / or potassium and particularly preferably of sodium, and at least one organic compound containing an ester group which hydrolyzes at a pH of 7.5 to 12 ,

Sweat is an aqueous secretion secreted by the skin of the human through the so-called sweat glands. There are three types of sweat glands in the skin, namely apocrine, eccrine, and apoekrine sweat glands (Int J Cosmet Sei. 2007 Jun; 29 (3): 169-79).

The eccrine sweat glands in humans are distributed practically throughout the body and can produce significant amounts of a clear, odorless secretion that is over 99% water. In contrast, the apocrine sweat glands come only in the hairy body areas of the armpit and genital region and the

Nipples before. They produce small amounts of a milky secretion that contains proteins and lipids and is chemically neutral.

Sweating, also known as transpiration, is an effective mechanism to release excess heat and thereby regulate body temperature. The volume-rich aqueous secretion of the eccrine glands, which is used in the

Adults can produce up to 2-4 liters per hour or 10-14 liters a day.

The sweat - especially the secretion of apocrine sweat glands - is also signaled by the sense of smell. In humans, the apocrine sweat plays in particular in the context of the emotional or

Stress-related sweating plays a role.

Cosmetic antiperspirants or deodorants / deodorants serve to

To eliminate body odor or to reduce its formation. Body odor arises when the per se odorless fresh sweat by microorganisms such.

Staphylococci and Corynebacteria is decomposed. In common usage, there is not always a clear distinction between the terms "deodorant" and "antiperspirant". Rather, especially in the

German-speaking countries - products for use in the underarm area generally referred to as deodorants or "deodorants". This is irrelevant to the question of whether an antiperspirant effect is present.

Antiperspirants (AT) are antiperspirants that - in contrast to the

Deodorants, which generally prevent microbial decomposition of already formed sweat - to prevent the secretion of sweat at all.

In contrast to the antiperspirants pure deodorants cause no active

Influencing the sweat secretion, but only the control or influence of the body or armpit odor (odor control agent). The usual cosmetic deodorants are based on different active principles.

Common mechanisms of action for this are antibacterial effects, such as e.g. Non-colloidal silver also shows odor neutralization (masking), influence on bacterial metabolisms, pure perfuming as well as the use of precursors of certain perfume components, which are converted into fragrant substances by enzymatic reactions.

Sweat odor consists to a large extent of branched-chain fatty acids, which are released by bacterial enzymes from odorless sweat. Classic deodorizing agents counteract this by reducing the growth of bacteria. Frequently, however, the substances used here are also unselective and useful

Skin germs and can lead to sensitive people to skin irritation.

The classic antiperspirants used are, in particular, aluminum salts or aluminum / zirconium salts. These inhibit the flow of sweat by obstructing the excretory ducts of the sweat glands by precipitating them together with the skin's own proteins and thus leading to so-called plugs. Therefore, there may be a congestion of sweat within the gland.

The effect of antiperspirants based on Al salts against thermal sweating under normal physiological conditions has been well studied. Whether this obstruction is caused by denaturation of keratin or by clumping of corneocytes in the sweat gland duct (Shelley WB and Hurley HJ, Acta.

Derm. Venereol. (1975) 55: 241-60), or by the formation of an ACH / AZG gel (Reller HH and Luedders WL, in: Advances in Modern Toxicology, Dermatoxicology and

Pharmacology, F.N. Marzulli and H.l. Maibach, Eds. Hemisphere Publishing Company, Washington and London (1977) Vol. 4: 1-5)

Sweat gland duct is still open.

The thus obtained and known constipation is effective only in the short term. Heavy sweating or armpit cleaning as part of the normal body cleansing routine relieve the constipation and thus the antiperspirant effect. However, the resulting need to apply antiperspirant (AT) products at least once a day may cause skin irritation, especially after shaving or in or on previously damaged areas of the skin.

In addition, such aluminum salts as aluminum hydroxychlorides can cause skin damage if used frequently and on sensitive persons. In addition, the use of the aluminum salts can cause discoloration of textiles which come into contact with the antiperspirant.

The additional use of antimicrobial substances in cosmetic antiperspirants can reduce the bacterial flora on the skin. Ideally, only the odor causing microorganisms should be effectively reduced. The sweat flow itself is not affected, in the ideal case, only the microbial decomposition of the

Sweat temporarily stopped.

Usually antiperspirants (AT) and deodorants (Deo) are offered in a variety of product forms, with scooters, pump sprayers and aerosols dominating in Europe, and deodorant sticks ("sticks") in the US, Central and South America. Both anhydrous (suspensions) and water-containing products (hydro-alcoholic formulations, emulsions) are known.

A disadvantage of the aluminum salts used hitherto for sweat inhibition is the currently not yet fully understood long-term toxicity. Aluminum has long been suspected of promoting or inducing neurodegenerative diseases such as dementia, particularly Alzheimer's disease. Also, aluminum is associated with the onset of breast cancer

Connected. So far there is no verified evidence that over the skin active aluminum-containing AT agents are involved. If the skin is intact, the maximum admissible intake levels can not be achieved.

In view of the data, however, the move away from aluminum-containing AT agents is advantageous, so that the industry is desperately looking for aluminum-free alternatives.

Because of this problem, it is desirable to provide products which achieve an antiperspirant effect without the use of Al salts.

An alternative to the aluminum salts is known from document FR 2977151 A1, which discloses antiperspirant preparations with sodium silicate.

Examples 1 to 3 are roll-on formulations containing sodium silicate, an acid and water. The pH of the formulations is in the range of 8 to 10. Using a roll-on formulation with a pH of 10, a sweat reduction of 9% was demonstrated in one study. Other examples disclose stick formulations containing sodium silicate and optionally an acid. All disclosed stick formulations are anhydrous. Among others, with C12-C15 alkyl benzoates and PEG-8 distearate esters in the

Containing formulations. The contained esters, however, show no hydrolysis reaction with the addition of water.

Further, FR 2977151 A1 discloses aerosol sprays containing sodium silicate and at least one acid. The preparations are anhydrous.

Furthermore, the prior art knows the Mintel product no. 93863 "Cool Cotton Deodorant", which is an aqueous formulation with fatty acids and various

Metal silicates is.

The effectiveness of sodium silicate as an antiperspirant active ingredient is attributable to the fact that an aqueous solution containing sodium silicate polymerizes or forms a gel at a pH of less than 1, thus blocking the

Sweat glands is coming. At a pH above 1 1 is an aqueous

Sodium silicate solution stable and there is no polymerization.

This polymerization behavior leads to some significant product disadvantages with respect to the known prior art. So it comes with the aqueous roll-on formulations of Examples 1 to 3 of FR 2977151 A1 to a rapid polymerization after preparation of the preparation. Thus, the preparation must be made directly before the orders and applied immediately. A provision as a cosmetic product for sale in the trade is thus not possible because it would come to a polymerization during storage. After gelation throughout the product, this is no longer applicable and no AT effect is achieved as it is not a temporary

Blockage of sweat glands comes.

Another disadvantage of the anhydrous preparations known from FR 2977151 A1 is that they contain at least one water-soluble, free acid. This leads to the fact that the pH of the preparation is immediately lowered when water is added. In the storage and use of these anhydrous preparations, it may also due to the presence of the water-soluble, free acid to a deactivation of the sodium silicate by

Surface polymerization come. Thus, upon entry of water, no sodium silicate solution initially forms. Instead, the polymerization already begins when the surface of the sodium silicate particles is dissolved. A complete solution of the sodium silicate particles is thus often prevented. As a result, solid particles are retained. Since in this way the polymerization or gelation often begins even before reaching the sweat gland, the antiperspirant activity is reduced. It is thus desirable to provide preparations in which the polymerization or gelation is delayed triggered to allow effective antiperspirant activity.

One way to prevent rapid polymerization or gel formation is to apply an aqueous sodium silicate solution directly to the skin at a high pH, for example pH 12, at which no polymerization takes place. On the skin then follows the natural regulation of the pH of the skin, which leads to a lowering of the pH. There is thus a delayed polymerization, but it comes in this

Procedure due to the high pH often to skin intolerances. It is particularly problematic that antiperspirant products are often applied several times a day on the skin, so that when repeated daily use, a constant high pH on the skin forms, which is not desirable.

A further disadvantage of known antiperspirant cosmetic preparations is that they do not develop their antiperspirant activity as a function of the perspiration production. Rather, it is desirable to provide preparations whose antiperspirant activity begins only with onset of sweat production. The object of the present invention was thus to provide a cosmetic preparation which does not have the disadvantages of the prior art.

Surprisingly, the object has been achieved by the subject matter of the present invention.

The invention relates to an anhydrous cosmetic preparation containing

a) at least one alkali metal silicate, preferably sodium silicate and / or potassium silicate, with sodium silicate being particularly preferred, and

b) at least one organic compound containing an ester group which hydrolyzes at a pH of 7.5 to 12.

The present invention also provides the use of the combination of at least one alkali metal silicate, preferably sodium silicate and / or potassium silicate, with sodium silicate being particularly preferred, and an organic compound containing an ester group which hydrolyzes at a pH of 7.5 to 12, to provide an antiperspirant, anhydrous cosmetic preparation which is applied to the skin and blocks sweat pores only at the onset of sweating.

The invention also provides a process for activating the antiperspirant activity of a cosmetic preparation on the skin, characterized in that, in a first step, a preparation containing the combination of at least one alkali metal silicate, preferably sodium silicate and / or potassium silicate, with sodium silicate being particularly preferred and at least one organic compound containing an ester group which hydrolyzes at a pH of 7.5 to 12, is applied to the skin and in a second step, water is added to the applied preparation, wherein the addition of water is preferably carried out by sweating.

Without being bound by theory, it is believed that according to orders

Preparation according to the invention, the alkali metal silicates according to the invention in addition to the organic compounds according to the invention containing an ester group on the skin. As soon as the sweat starts, the silicates are dissolved by the water. Due to the hydrolysis of the esters, acids are formed which retard the pH and delay the desired gel formation. The formation of acids prevents the pH on the skin from being strongly alkaline over a long period of time. Thus, there are no compatibility problems. It should be noted that it is only possible to define a pH value as soon as water is present. Thus, there is only an alkaline pH for a short time. Furthermore, it was surprising It has been found that when the combination according to the invention is used, there is no or only little loss of action in relation to the antiperspirant activity of the preparation.

If weight percentages are given below without reference to a particular composition or specific mixture, these figures always refer to the total weight of the cosmetic preparation. If ratios of components / substances / substance groups are disclosed below, these ratios relate to weight ratios of the abovementioned

Components / substances / groups.

Where ranges are given for the weight of certain ingredients, the indication includes not only the beginning and end values for the indicated ranges, but also the individual values within ranges in increments of 0.01% by weight.

Unless otherwise stated, all experiments and process steps are below

Normal conditions performed. The term "normal conditions" means 20 ° C, 1013 hPa and a relative humidity of 50%.

In the context of the present disclosure, the formulations "according to the invention", "advantageous according to the invention", and "advantageous for the purposes of the present invention" always refer both to the preparation according to the invention and to the use according to the invention and to the processes according to the invention.

If the term skin is used below, it refers exclusively to the human skin.

It is advantageous according to the invention if sodium silicate and / or potassium silicate are present in the cosmetic preparation as alkali metal silicate, sodium silicate being preferably present.

The substances having the empirical formula Na According to the invention under Natriumsilkaten ₂ 0 _x ₂ -y ^ understood Si0 O, wherein x = 1 and y = 0 to 9.

According to the invention, the preparation of the present invention is referred to as anhydrous. This definition means that no water is added to the preparation, but it is possible that salts as described above may be contained in the form of hydrates can. Accordingly, it is also possible according to the invention to use, for example, sodium silicates as pentahydrates (y = 5) or nonahydrate (y = 9). However, it is particularly preferred according to the invention if the preparation contains no water and thus also no water in the form of hydrates or water of crystallization is contained.

Accordingly, it is likewise particularly preferred if sodium silicate is present in anhydrous form in the preparation according to the invention.

A most preferred form of sodium silicate to be used is sodium metasilicate (CAS: 6834-92-0).

It is further advantageous according to the invention, if in the inventive

Preparation contained alkali metal silicates are particularly fine-grained. Accordingly, the alkali metal silicate contained in the preparation according to the invention is advantageously characterized in that it has a bulk density of at least 800 g / L, preferably at least 950 g / L and particularly preferably at least 1050 g / L.

Anhydrous sodium silicate having a bulk density of 1100 g / l can be obtained inter alia from the company SILMACO N.V., Belgium. Bulk density can be determined according to DIN EN ISO 60: 2000-01.

Furthermore, it is preferred if an alkali metal silicate with a middle

Equivalent diameter (particle size) of less than 250 pm, preferably less than 150 pm, and more preferably less than 50 pm is used. In particular, it is preferred if, as the alkali metal silicate, sodium silicate having a mean

Equivalent diameter (particle size) of less than 250 pm, preferably less than 150 pm, and more preferably less than 50 pm is used. The particle size can be determined by light scattering, the mean equivalent diameter resulting from a measurement of at least 100 particles.

According to the invention, the proportion of alkali metal silicates in the

According to the invention preparation of 0.25 wt .-% to 20 wt .-%, preferably 0.5 wt .-% to 8 wt .-% and particularly preferably 1 wt .-% to 3 wt .-%, each based on the Total weight of the preparation.

It is particularly advantageous if sodium silicate is contained as alkali metal silicate and the proportion of sodium silicate in the preparation of 0.25 wt .-% to 20 wt .-%, preferably 0.5 wt .-% to 8 wt .-% and particularly preferably 1 wt .-% to 3 wt .-%, each based on the total weight of the preparation.

According to the invention, the anhydrous cosmetic preparation contains at least one organic compound containing an ester group which hydrolyzes at a pH of 7.5 to 12. The statement for the hydrolysis of the ester group refers to

Normal conditions as defined above. Hydrolysis is considered to occur when a substance in a total amount of 0.1% by weight is added to an aqueous solution whose pH has been adjusted to 7.5 to 12 with caustic soda and within 20 minutes Under normal conditions, a pH change of at least 0.5, preferably at least 1, particularly preferably at least 4, takes place in the direction of the acidic pH range. The aqueous solution used contains only water and sodium hydroxide solution. An organic compound is considered to be in accordance with the invention if the required pH change occurs at at least one pH in the range from 7.5 to 12.

Particular preference should be given to using organic compounds containing an ester group which hydrolyzes at a pH of 11. Here, too, hydrolysis is considered to have occurred when a substance in a total proportion of 0.1% by weight is added to an aqueous solution whose pH has been adjusted to 11 with sodium hydroxide and within 20 minutes under normal conditions a pH change of at least 0.5, preferably at least 1, especially preferably at least 4, takes place in the direction of the acidic pH range.

A preferred subject of the invention is therefore an anhydrous cosmetic

Containing preparation

b) at least one organic compound containing an ester group which hydrolyzes at a pH of 11.

Furthermore, it is advantageous if the organic compound b) according to the invention is water-soluble.

In the hydrolysis of the organic compound b), various substances can be formed. For example, if there is hydrolysis of a linear carboxylic acid ester, so form a carboxylic acid and an alcohol. However, it is also possible for the hydrolysis to open the ring and thus continue to retain only one molecule.

The organic compounds b) according to the invention include, inter alia

Carboxylic acid esters, anhydrides or lactones. Decisive is their functionality, which is based on the fact that a contained ester group hydrolyzed at a pH of 7.5 to 12 or hydrolyzed in particular at a pH of 11. During the hydrolysis, an acid group is formed from organic compounds which are advantageous according to the invention. Furthermore, the organic compounds b) according to the invention may contain one or more ester groups which hydrolyze at a pH of 7.5 to 12.

A first advantageous group (A) of organic compounds b) according to the invention are non-cyclic esters of carboxylic acids and alcohols, the alcohol preferably being ethanol. Preferred examples of this group are oxalic acid diesters and ethyl lactate, with lactic acid ethyl ester being particularly preferred. According to the invention, the polymeric ester compounds of group (C) do not belong to the organic compounds of group (A).

A second advantageous group (B) according to the invention of organic compounds b) are cyclic esters advantageously selected from the group of lactones and cyclic diesters of hydroxycarboxylic acids. The lactones of the invention include gluconic acid 1, 5-lactone, glucuric acid-6,3-lactone, 3,5-dihydroxy-3-methylpentanoic acid 5-lactone, ribosäure-1, 4-lactone, galactonic acid-1, 4-lactone, Glucono-1, 4-lactone, Mannoic Acid-1, 4-lactone. The cyclic diesters of α-hydroxycarboxylic acids include, among others, the lactide (lactides). Gluconic acid 1, 5-lactone and / or lactide are preferably selected. As the lactide, it is possible to use both the (S, S) -lactide, the (R, R) -lactide, the meso-lactide or mixtures of these isomers.

A third group (C) of organic compounds b) which is advantageous according to the invention represents polymeric ester compounds. Polymeric ester compounds are non-cyclic esters which are composed of at least 3 identical monomeric esters. A preferred example of such an ester compound is the polylactic acid, which further preferably has an average molecular weight of less than 5000 Da, more preferably less than 2000 Da, and further preferably less than 500 Da and

especially preferably has less than 300 Da. About the chain length of

Polylactic acid can be used to control the hydrolysis rate. The longer the chain length, that is, the higher the molecular weight, the slower the hydrolysis proceeds. Another group (D) of organic compounds b) which is advantageous according to the invention are acid anhydrides. Known examples include acetic anhydrides or

Succinic anhydride. However, this group of organic compounds b) are less preferred since they often react very acidically or toxicologically for cosmetic

Products are less suitable.

According to the invention, all organic compounds b) of the abovementioned groups can also be used in combination, preference being given to a combination of groups (A), (B) and (C). Particularly preferred is a combination of groups (A) and (B).

The total amount of the organic compounds b) according to the invention in the

cosmetic preparations of the invention is advantageously from 0.5% by weight to 25% by weight, preferably from 1% by weight to 20% by weight and particularly preferably from 4% by weight to 12% by weight, based on the total weight of the cosmetic preparation.

Furthermore, advantageous embodiments of the invention are characterized in that the weight ratio of the alkali metal silicates to that of organic compounds b) is 1: 1 to 1:50, preferably 1: 2 to 1: 5.

The state of aggregation of the organic compounds b) used is either solid or liquid under normal conditions. If solid organic compounds b) are used, ie the organic compounds b) are solids, it has proved to be advantageous if these organic compounds b) are water-soluble, but the solubility of the organic compounds b) is lower than the water solubility the silicate used of the alkali metals. This leads to the fact that when the onset of sweating, the silicates are first dissolved and can penetrate into the sweat glands, before the hydrolysis of the organic compound b) begins and the pH is lowered, which triggers the desired gel formation. That way, one becomes

achieved surprisingly effective sweat reduction. Accordingly, advantageous embodiments of the invention are also characterized in that the organic compound b) used is solid under normal conditions and the solubility of the organic compounds b) in water is lower than the water solubility of the silicate used of the alkali metals. If the organic compounds b) are solid under normal conditions, it is furthermore advantageous if they are as fine-grained as possible. Solid organic compounds b) having a mean equivalent diameter of less than 150 square meters, preferably less than 50 square meters, and in particular less than 10 square meters, are advantageously used. Through the use of particularly fine-grained solid organic compounds b), a lumping or a rough feeling on the skin is reduced and / or prevented. Here, too, the particle size can be determined by light scattering, the mean equivalent diameter resulting from a measurement of at least 100 particles.

Advantageous embodiments of the invention are further characterized in that the anhydrous cosmetic preparations according to the invention contain no acids. That is, the proportion of acids in the preparation according to the invention is 0 wt .-%, based on the total weight of the preparation.

Further advantageous embodiments of the invention are further characterized in that the anhydrous cosmetic preparations according to the invention no

contain water-soluble acids. That is, the proportion of the water-soluble acids in the preparation according to the invention is 0 wt .-%, based on the total weight of the preparation.

It is also advantageous if the cosmetic preparations of the invention contain no aluminum salts, in particular no aluminum chlorohydrate.

In general, it is furthermore advantageous if the cosmetic preparations according to the invention contain silicone oils. Depending on the product form, the proportion of silicone oils may vary. In general, however, the proportion of silicone oils is advantageously at least 30% by weight, based on the total weight of the cosmetic preparation.

The combination according to the invention can be used in a wide variety of anhydrous

cosmetic preparations for use under the armpit. These include creams, pump sprays, aerosol sprays, gels, solid sticks or roll-on

Formulations.

A first advantageous embodiment of the invention is an aerosol spray containing the combination according to the invention. An aerosol spray is a pressure vessel provided with a dispensing valve and containing the cosmetic preparation according to the invention and at least one propellant gas. According to the invention, the propellant gases are advantageously selected from the group consisting of propane, n-butane, isobutane, pentane and / or nitrogen. Less suitable to use

Chlorofluorocarbons, which affect the environment and therefore for the

Application in cosmetic products are not suitable for the mass market. It is furthermore particularly advantageous if the propellant gases are selected from the group consisting of propane, n-butane and isobutane.

Preference is given to using mixtures having pressure stages of from 1.0 to 3.5 bar. Preferably from 2.5 to 3.2, most preferably a pressure of 3.0 bar.

Preferred filling ratios based on the weight of the cosmetic preparation to propellant gas are 40:60 to 2:98, preferably 25:75 to 3:97, most preferably 6:94.

Within the first advantageous embodiment of the invention, it is furthermore advantageous if the cosmetic preparation contains one or more silicone oils. The

Silicone oils according to the invention can be selected from linear silicone oils (dimethicones) and cyclic silicone oils (cyclosilicone).

If the cosmetic preparation of the first advantageous embodiment contains silicone oils, it is preferred according to the invention if the proportion of silicone oils in the cosmetic preparation is 50% by weight to 70% by weight, based on the total weight of the cosmetic preparation.

Furthermore, it is advantageous if the cosmetic preparation according to the first

advantageous embodiment of the invention Dimethiconol contains.

If the cosmetic preparation according to the first advantageous embodiment contains dimethiconol, it is furthermore advantageous if the proportion of dimethiconol is from 6% by weight to 12% by weight, based on the total weight of the cosmetic preparation.

Furthermore, it is advantageous if the cosmetic preparation of the first advantageous

Embodiment of the invention contains one or more natural oils. A particularly advantageous to be used oil is Persea Gratissima Oil. Furthermore, it is advantageous if the cosmetic preparation of the first advantageous embodiment of the invention contains isopropyl palmitate. Contains the cosmetic

Preparation of the first advantageous embodiment Isopropyl palmitates, it is preferred if the proportion of isopropyl palmitates is from 5% by weight to 15% by weight, based on the total weight of the cosmetic preparation.

Embodiment of the invention contains Disteardiamoniumhectorit. Contains the cosmetic preparation of the first advantageous embodiment Disteardiamoniumhectorit, it is preferred if the proportion of Disteardiamoniumhectorit of 1 wt .-% to 5 wt .-% based on the total weight of the cosmetic preparation.

Furthermore, it is advantageous according to the invention if the cosmetic preparation according to the first advantageous embodiment contains further components, such as further oils and / or perfumes, which are advantageously selected from the group sunflower oil, rapeseed oil, PPG-14 butyl ether, C12-15 alkyl benzoate, capric / Caprylic Triglyceride, Isopropyl Myristate, Isopropyl Stearate, Cetearyl Ethylhexanoate, Hydrogenated Polydecenes,

Paraffinum Liquidum, PPG-15 Stearyl Ether, Glycine Soybean (Soybean) Oil, Olive Oil, Guerbet Alcohols; especially hexyldecanol, octyldodecanol and 2-ethylhexyl alcohol;

Guerbet alcohol esters, and mixtures of Guerbet alcohols and Guerbet alcohol esters (such as hexyldecanol and hexyldecyl laurate).

In a second advantageous embodiment according to the invention, the cosmetic preparation according to the invention is in the form of a stick. Within this embodiment, it is preferred if the cosmetic preparation contains silicone oils in a proportion of 30% by weight to 50% by weight, based on the total weight of the cosmetic preparation. The silicone oils according to the invention can be chosen from linear silicone oils (dimethicones) and cyclic silicone oils (cyclosilicone).

Furthermore, in the second advantageous embodiment it is preferred if the cosmetic preparation contains one or more fatty alcohols, in particular stearyl alcohol. If the preparation contains fatty alcohols, it is furthermore preferred if the proportion of the fatty alcohols is from 15% by weight to 30% by weight, based on the total weight of the cosmetic preparation.

Furthermore, in the second advantageous embodiment, it is preferred if the cosmetic preparation contains PPG-14 butyl ether. Does the preparation contain PPG-14 butyl Ether, it is further preferred if the proportion of PPG-14 butyl ether from 10 wt .-% to 20 wt .-%, based on the total weight of the cosmetic preparation is.

Furthermore, in the second advantageous embodiment, it is preferred if the cosmetic preparation contains talc. If the preparation contains talc, it is further preferred if the proportion of talc of 4 wt .-% to 8 wt .-%, based on the

Total weight of the cosmetic preparation is.

Furthermore, in the second advantageous embodiment, it is preferred if the cosmetic preparation contains hydrogenated castor oil. If the preparation contains hydrogenated castor oil, it is furthermore preferred if the proportion of hydrogenated castor oil is from 0.5% by weight to 4% by weight, based on the total weight of the cosmetic preparation.

Furthermore, in the second advantageous embodiment, it is preferred if the cosmetic preparation contains glyceryl stearate SE. If the preparation contains glyceryl stearate SE, it is furthermore preferred if the proportion of glyceryl stearate SE is from 0.2% by weight to 0.9% by weight, based on the total weight of the cosmetic preparation.

Furthermore, it is advantageous according to the invention if the cosmetic preparation according to the second advantageous embodiment contains further components, such as further oils and / or perfumes, which are advantageously selected from the group sunflower oil, rapeseed oil, C12-15 alkyl benzoate, Capric / Caprylic triglyceride, isopropyl myristates .

Isopropyl Palmitate, Isopropyl Stearate, Cetearyl Ethyl Hexanoate, Hydrogenated Polydecenes, Paraffinum Liquidum, PPG-15 Stearyl Ether, Avocado Oil (Persea Gratissima Oil), Glycine Soybean (Soybean) Oil, Olive Oil, Guerbet Alcohols; especially hexyldecanol, octyldodecanol and 2-ethylhexyl alcohol; Guerbet alcohol esters, and mixtures of Guerbet alcohols and Guerbet alcohol esters (such as hexyldecanol and hexyldecyl laurate).

Preparations of the third advantageous embodiment are often described as soft solid. These preparations are advantageously characterized in that they are not flowable under normal conditions under its own weight but deformable.

Such preparations are unlike pencils under normal conditions not fixed. The preparations of the third advantageous embodiments are composed according to the following description. Advantageously, the cosmetic preparation of the third advantageous embodiment, based on the total weight of the cosmetic preparation, silicone oils in a proportion of 60 wt .-% to 75 wt .-%. The silicone oils according to the invention can be chosen from linear silicone oils (dimethicones) and cyclic silicone oils (cyclosilicone).

Furthermore, it is preferable in the third advantageous embodiment, when the

cosmetic preparation contains PPG-14 butyl ether. If the preparation contains PPG-14 butyl ether, it is furthermore preferred if the proportion of PPG-14 butyl ether is from 5% by weight to 15% by weight, based on the total weight of the cosmetic preparation.

Furthermore, it is preferable in the third advantageous embodiment, when the

cosmetic preparation Cera Microcristallina contains. Contains the preparation Cera

Microcrystalline, so it is further preferred if the proportion of Cera Microcristallina of 3 wt .-% to 7 wt .-%, based on the total weight of the cosmetic preparation is.

Furthermore, it is preferable in the third advantageous embodiment, when the

cosmetic preparation containing hydrogenated castor oil. If the preparation contains hydrogenated castor oil, it is furthermore preferred if the proportion of hydrogenated castor oil is from 0.5% by weight to 4% by weight, based on the total weight of the cosmetic preparation.

Furthermore, it is preferable in the third advantageous embodiment, when the

cosmetic preparation containing Silica Dimethyl Silylate. If the preparation contains silica dimethyl silylates, it is furthermore preferred if the proportion of silica dimethyl silylates is from 0.5% by weight to 4% by weight, based on the total weight of the cosmetic

Preparation is.

Furthermore, it is advantageous according to the invention if the cosmetic preparation according to the third advantageous embodiment contains further components, such as further oils and / or perfumes, which are advantageously selected from the group sunflower oil, rapeseed oil, C12-15 alkyl benzoate, Capric / Caprylic triglyceride, isopropyl myristate .

Isopropyl Palmitate, Isopropyl Stearate, Cetearyl Ethyl Hexanoate, Hydrogenated Polydecenes, Paraffinum Liquidum, PPG-15 Stearyl Ether, Avocado Oil (Persea Gratissima Oil), Glycine Soybean (Soybean) Oil, Olive Oil, Guerbet Alcohols; especially hexyldecanol, octyldodecanol and 2-ethylhexyl alcohol; Guerbet alcohol esters, and mixtures of Guerbet alcohols and Guerbetalkoholestem (such as hexyldecanol and hexyldecyl laurate).

Furthermore, it is possible to provide further embodiments of the invention. An application of the combination according to the invention is therefore also possible in anhydrous roll-on formulations. Roll-on formulations are formulations that are about one

Commercially available roll-on applicator, in particular a deodorant roll-on applicator can be applied to the armpit. The anhydrous roll-on formulations comprising the combination according to the invention advantageously have a viscosity of a viscosity in the range of 1000 to 5000 mPas, measured 1 day after preparation with a Brookfield viscometer, spindle RV 4, 20 s-1, without Helipath, at 20 ° C ambient temperature and 20 ° C sample temperature m, on.

Furthermore, the roll-on formulations according to the invention are advantageously characterized in that they contain silicone oils in a proportion of at least 40% by weight, based on the total weight of the preparation, or of the roll-on formulation.

Furthermore, it is inventively advantageous if the roll-on invention

Formulations advantageously other components, such as other oils and / or perfumes containing, which are advantageously selected from the group sunflower oil, rapeseed oil, PPG-14 butyl ether, C12-15 alkyl benzoate, Capric / Caprylic triglyceride, isopropyl myristates,

All cosmetic preparation according to the invention may further cosmetic

Excipients and other active ingredients, as commonly used in

Antiperspirant preparations are used, such as. B. preservatives,

Preservatives, bactericides, perfumes, foaming inhibitors, colorants and pigments, thickeners, moisturizing and / or moisturizing substances, fats, oils, waxes or other common ingredients of a cosmetic or dermatological formulation, such as alcohols, polyols, polymers, foam stabilizers, ganic solvents or other silicone derivatives if the additive does not impair the required properties or is excluded according to the invention. The hydrolysis behavior of various esters is examined below by way of example. For this purpose, in each case water and sodium hydroxide were mixed so that an aqueous

Sodium hydroxide solution was obtained with a pH of 1 1. Subsequently, 0.1% by weight each of an ester was added to the sodium hydroxide solution, and the pH of the solution was measured again after 20 minutes.

The following measurements were obtained:

As can be seen from the above table, hydrolysis according to the invention takes place only in the case of the lactides and the gluconic acid-1, 5-lactone, while isopropyl palmitates and glyceryl stearate SE are not hydrolyzed. Thus, the lactides and gluconic acid-1, 5-lactone organic compounds containing an ester group, while isopropyl palmitate and glyceryl stearate SE are not according to the invention.

If one examines the hydrolysis of the lactide in detail, it has been shown that the pH of the aqueous sodium hydroxide solution is only lowered by a pH of 1 within 5 minutes after addition, followed by a rapid lowering of the pH to 4.55 20 minutes. Thus, the lowering of the pH is surprisingly delayed significantly.

Further advantageous embodiments of the invention are thus characterized in that the organic compound b) is characterized in that it has a pH value of 11 within 5 when added in a proportion of 0.1% by weight to an aqueous sodium hydroxide solution Minutes after addition, the pH is lowered to not less than 9.5 and 20 minutes after addition, a pH of less than 6, wherein the wt .-% fraction based on the total composition of the sodium hydroxide solution and the organic compound relates. For a further experiment, the pen formulations listed below were prepared. For this purpose, all components 1 to 5 were heated to 90 ° C and mixed.

Subsequently, the addition of components 6 to 8, without the mixture further heat was supplied. At 66 ° C then followed by the addition of

Component 9. The mixture of all ingredients was poured into stick molds at 65 ° C as a homogeneous mass. Unless indicated otherwise, all amounts, proportions and percentages are based on the weight and the total amount or on the total weight of the preparations.

The stick of Ex.1 contains the gluconic acid-1, 5-lactone as an organic compound having an ester group. Ex.2 contains no such compound and is thus not an example according to the invention. The pins of Ex.1 and Ex.2 were used for further pH studies. In a first study, in each case 2 g of the respective stick of Examples Bsp.1 and Bsp.2 were added to 200 g of water and the pH of the solution was measured as a function of time. The measured values are shown in Figure 1 (Fig.1). When adding the preparation of Example 2, a continuous increase in the pH, while the addition of the preparation of Example 1, a first increase in pH takes place before the pH decreases again 3 minutes after addition and so in one skin-compatible area remains.

In a second study, 0.5 g each of the respective pencils of Examples Bsp.1 and Bsp.2 was applied to an area of 100 cm ² in each armpit of a test person. The pH of each skin area was measured once before application of the example formulations and then at various times after application. The results are shown in Figure 2. During the measuring time, the test person behaved calmly, so that no above-average sweat flow is to be expected. The The amount of added water is therefore limiting in comparison to the previous study.

The pH of the axilla with Ex.1 before application was determined to be 6.1. The pH of the armpit with Ex.2 before application was determined to be 5.2. 30 minutes after the orders, a pH of 9.7 was determined for the armpit with the example formulation Ex.1, while the armpit with the example formulation Ex.2 has a pH value of 12. After 120 minutes, a pH of 7.3 for the underarm was determined with the example formulation Ex.1 and a pH of 9.4 for the armpit with the example formulation Ex.2. Thus, the leads

Application of the inventive example a significantly better skin compatibility than the application of the example not according to the invention.

To demonstrate the antiperspirant effect of the preparations according to the invention, the following examination was carried out. For the quantitative measurement of the AT-performance, the reduction of the amount of sweat on the forearm was determined gravimetrically.

Preconditioning / behavior during the study

Study participants did not use any leave-on products (such as hand creams) or washing substances on the underarm area for at least three days before the study, as well as during the course of the study.

Likewise during the study days the subjects are forbidden sweaty sports, sauna sessions and solarium, sun baths and swimming pool visits.

Measurement

Before application of the test substances, the forearms are washed with a surfactant-containing solution. Subsequently, the test areas are recorded with the aid of a template on the forearm (inner side) for the recovery in the multiple application and the preparations of the example formulations Bsp.1 and Bsp.2 are each applied to the areas. In addition, areas remained untreated and thus served as a reference. 24 hours after application, a liquid-absorbing matrix (for example a cotton pad) was fixed on the test areas. The volunteers then spent 20 minutes on an ergometer to stimulate the sweat flow. After completion, a gravimetric evaluation of the liquid-absorbent matrix was carried out. Nine subjects participated in the study, each sample being examined twice in each subject. In reference to the untreated control, the example formulation Ex.1 showed a sweat reduction with the median of 15%, while the median of the example formulation Ex.2 was 17%. Both values are to be regarded as comparable within the study designs. The present comparative experiments thus show that the formulations according to the invention have a comparable sweat reduction with a significantly improved skin compatibility. The skin is less exposed to high pH levels.

The following examples are intended to illustrate the present invention without restricting it.

Aerosol spray:

¹ SILMACO, fine powder, bulk density 1100 g / L, particle size <250 pm

pencils

¹ SILMACO, fine powder, bulk density 1 100 g / L, particle size <250 pm

Soft solid / gel-like formulation:

1SILMACO, fine powder, bulk density 1100 g / L, particle size <250 pm

Claims

claims

1. Anhydrous cosmetic preparation containing

a) at least one alkali metal silicate, preferably sodium silicate and / or

Potassium silicate, with sodium silicate being particularly preferred, and b) at least one organic compound containing an ester group which hydrolyzes at a pH of 7.5 to 12.

2. Preparation according to claim 1, characterized in that is contained as alkali metal silicate Natriummetasilikat.

3. Preparation according to one of the preceding claims, characterized in that the alkali metal silicate advantageously characterized in that it has a bulk density of at least 800 g / L, preferably at least 950 g / L and

more preferably at least 1050 g / L.

4. Preparation according to one of the preceding claims, characterized in that the alkali metal silicate has a mean equivalent diameter of less than 250 pm, preferably less than 150 pm and more preferably less than 50 pm.

5. Preparation according to one of the preceding claims, characterized in that the proportion of alkali metal silicates of 0.25 wt .-% to 20 wt .-%, preferably 0.5 wt .-% to 8 wt .-% and particularly preferably 1 wt .-% to 3 wt .-%, each based on the total weight of the preparation is.

6. Preparation according to one of the preceding claims, characterized in that the organic compound b) contains an ester group which hydrolyzes at a pH of 1 1.

7. Preparation according to one of the preceding claims, characterized in that the organic compound b) is water-soluble.

8. Preparation according to one of the preceding claims, characterized in that the organic compound b) is selected from the group

(A) the non-cyclic ester of carboxylic acids and alcohols, wherein the alcohol is preferably ethanol; (B) the cyclic ester, advantageously selected from the group of lactones and cyclic diesters of α-hydroxycarboxylic acids;

(C) the polymeric ester compounds which are at least 3

identical monomers are constructed; and or

(D) the acid anhydrides;

wherein the polymeric ester compounds of group (C) do not belong to the organic compounds of group (A).

9. Preparation according to one of the preceding claims, characterized in that as organic compound b) oxalic acid diester and / or lactic acid ethyl ester are contained.

10. Preparation according to one of the preceding claims, characterized in that as organic compound b) gluconic acid 1, 5-lactone, glucuric acid-6,3-lactone, 3,5-dihydroxy-3-methylpentanoic acid 5-lactone, ribosäure-1, 4-lactone, galactonyl-1, 4-lactone, gluconic acid-1, 4-lactone, maleic acid-1, 4-lactone and / or lactide are included.

11. Preparation according to one of the preceding claims, characterized in that as organic compound b) polylactic acid is contained, this preferably having an average molecular weight of less than 5000 Da, more preferably less than 2000 Da and further preferably less than 500 Da and most preferably less than 300 Da.

12. Preparation according to one of the preceding claims, characterized in that the total content of the organic compounds b) from 0.5 wt .-% to 25 wt .-%, preferably from 1 wt .-% to 20 wt .-% and particularly preferably of 4 wt .-% to 12 wt .-%, based on the total weight of the cosmetic preparation is.

13. Preparation according to one of the preceding claims, characterized in that the weight ratio of the alkali metal silicates to the organic

Compounds b) is 1: 1 to 1:50, preferably 1: 2 to 1: 5.

14. Preparation according to one of the preceding claims, characterized in that no water-soluble acids are contained.

15. A method for activating the antiperspirant efficacy of a cosmetic

Preparation on the skin, characterized in that in a first step a Preparation comprising the combination of at least one alkali metal silicate, preferably sodium silicate and / or potassium silicate, with sodium silicate being particularly preferred, and at least one organic compound containing an ester group, which hydrolyzes at a pH of 7.5 to 12, applied to the skin and water is added to the applied preparation in a second step, wherein the addition of water is preferably carried out by sweating.