WO2019211874A3 - A liquid cornea hydrogel composition - Google Patents

A liquid cornea hydrogel composition Download PDF

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Publication number
WO2019211874A3
WO2019211874A3 PCT/IN2019/050353 IN2019050353W WO2019211874A3 WO 2019211874 A3 WO2019211874 A3 WO 2019211874A3 IN 2019050353 W IN2019050353 W IN 2019050353W WO 2019211874 A3 WO2019211874 A3 WO 2019211874A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydrogel composition
liquid cornea
extracellular matrix
liquid
present disclosure
Prior art date
Application number
PCT/IN2019/050353
Other languages
French (fr)
Other versions
WO2019211874A2 (en
Inventor
Arun CHANDRU
Tuhin BHOWMICK
Tanmay GHARAT
Vivek Singh
Sayan BASU
Virender S SANGWAN
Original Assignee
Pandorum Technologies Private Limited
Hyderabad Eye Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pandorum Technologies Private Limited, Hyderabad Eye Research Foundation filed Critical Pandorum Technologies Private Limited
Publication of WO2019211874A2 publication Critical patent/WO2019211874A2/en
Publication of WO2019211874A3 publication Critical patent/WO2019211874A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/225—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633—Extracellular matrix [ECM]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present disclosure discloses a Liquid Cornea composition comprising: at least one polymer; an antifibrinolytic agent; decellularized extracellular matrix; at least one extracellular matrix cross-linker; and calcium chloride (CaCl2). Also provided is a method for preparing the liquid cornea composition. The present disclosure also discloses a process for obtaining the decellularized extracellular matrix.
PCT/IN2019/050353 2018-05-02 2019-05-02 A liquid cornea hydrogel composition WO2019211874A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201841016644 2018-05-02
IN201841016644 2018-05-02

Publications (2)

Publication Number Publication Date
WO2019211874A2 WO2019211874A2 (en) 2019-11-07
WO2019211874A3 true WO2019211874A3 (en) 2020-01-02

Family

ID=66589604

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2019/050353 WO2019211874A2 (en) 2018-05-02 2019-05-02 A liquid cornea hydrogel composition

Country Status (1)

Country Link
WO (1) WO2019211874A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2491960A1 (en) * 2009-10-23 2012-08-29 Sewon Cellontech Co., Ltd Composition for cartilaginous tissue repair and a production method therefor
EP2932989A1 (en) * 2012-12-11 2015-10-21 Sewon Cellontech Co., Ltd Tissue sealant in which collagen and fibrin are mixed, and method for preparing same
EP2995326A1 (en) * 2013-05-07 2016-03-16 The Chemo-Sero-Therapeutic Research Institute Hybrid gel containing particulate decellularized tissue
WO2017024193A1 (en) * 2015-08-06 2017-02-09 The Johns Hopkins University Immunomodulatory extracellular matrix nanoparticles
WO2018069563A1 (en) * 2016-10-14 2018-04-19 Universidad De Granada Bioartificial membranes having controlled viscoelasticity and rigidity for use in tissue engineering

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2491960A1 (en) * 2009-10-23 2012-08-29 Sewon Cellontech Co., Ltd Composition for cartilaginous tissue repair and a production method therefor
EP2932989A1 (en) * 2012-12-11 2015-10-21 Sewon Cellontech Co., Ltd Tissue sealant in which collagen and fibrin are mixed, and method for preparing same
EP2995326A1 (en) * 2013-05-07 2016-03-16 The Chemo-Sero-Therapeutic Research Institute Hybrid gel containing particulate decellularized tissue
WO2017024193A1 (en) * 2015-08-06 2017-02-09 The Johns Hopkins University Immunomodulatory extracellular matrix nanoparticles
WO2018069563A1 (en) * 2016-10-14 2018-04-19 Universidad De Granada Bioartificial membranes having controlled viscoelasticity and rigidity for use in tissue engineering

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ANNA KORNMULLER ET AL: "Fabrication of Extracellular Matrix-derived Foams and Microcarriers as Tissue-specific Cell Culture and Delivery Platforms", JOURNAL OF VISUALIZED EXPERIMENTS, no. 122, 11 April 2017 (2017-04-11), XP055646745, DOI: 10.3791/55436 *
ANWAR H M ET AL: "The use of fibrin glue to seal descemet membrane microperforations occurring during deep anterior lamellar keratoplasty", CORNEA 2012 LIPPINCOTT WILLIAMS AND WILKINS USA, vol. 31, no. 10, October 2012 (2012-10-01), pages 1193 - 1196, ISSN: 0277-3740 *
DATABASE EMBASE [online] ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; October 2012 (2012-10-01), ANWAR H M ET AL: "The use of fibrin glue to seal descemet membrane microperforations occurring during deep anterior lamellar keratoplasty", XP002793352, Database accession no. EMB-2012542413 *
DATABASE WPI Week 201831, Derwent World Patents Index; AN 2018-30867S, XP002793351 *
GILBERT T W ET AL: "Production and characterization of ECM powder: implications for tissue engineering applications", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 26, no. 12, 1 April 2005 (2005-04-01), pages 1431 - 1435, XP027767744, ISSN: 0142-9612, [retrieved on 20050401] *
IRONA KHANDAKER ET AL: "Regeneration of Corneal Stromal Tissue Using Components of Extracellular Matrix | IOVS | ARVO Journals", ARVO ANNUAL MEETING ABSTRACT, 29 April 2018 (2018-04-29), Honulu, Hawaii, US, XP055610455, Retrieved from the Internet <URL:https://iovs.arvojournals.org/article.aspx?articleid=2690433&resultClick=1> [retrieved on 20190801] *
MARK AHEARNE ET AL: "Early Observation of Extracellular Matrix-Derived Hydrogels for Corneal Stroma Regeneration", TISSUE ENGINEERING. PART C, METHODS DEC 2008, vol. 21, no. 10, 1 October 2015 (2015-10-01), US, pages 1059 - 1069, XP055610427, ISSN: 1937-3384, DOI: 10.1089/ten.tec.2015.0008 *

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