WO2019210423A1 - Attractants for mice - Google Patents
Attractants for mice Download PDFInfo
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- WO2019210423A1 WO2019210423A1 PCT/CA2019/050586 CA2019050586W WO2019210423A1 WO 2019210423 A1 WO2019210423 A1 WO 2019210423A1 CA 2019050586 W CA2019050586 W CA 2019050586W WO 2019210423 A1 WO2019210423 A1 WO 2019210423A1
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- composition
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- range volatiles
- range
- volatiles
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01M—CATCHING, TRAPPING OR SCARING OF ANIMALS; APPARATUS FOR THE DESTRUCTION OF NOXIOUS ANIMALS OR NOXIOUS PLANTS
- A01M25/00—Devices for dispensing poison for animals
- A01M25/002—Bait holders, i.e. stationary devices for holding poisonous bait at the disposal of the animal
- A01M25/004—Bait stations, i.e. boxes completely enclosing the bait and provided with animal entrances
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01M—CATCHING, TRAPPING OR SCARING OF ANIMALS; APPARATUS FOR THE DESTRUCTION OF NOXIOUS ANIMALS OR NOXIOUS PLANTS
- A01M23/00—Traps for animals
- A01M23/16—Box traps
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aliphatically bound aldehyde or keto groups, or thio analogues thereof; Derivatives thereof, e.g. acetals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N45/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds having three or more carbocyclic rings condensed among themselves, at least one ring not being a six-membered ring
- A01N45/02—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds having three or more carbocyclic rings condensed among themselves, at least one ring not being a six-membered ring having three carbocyclic rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01M—CATCHING, TRAPPING OR SCARING OF ANIMALS; APPARATUS FOR THE DESTRUCTION OF NOXIOUS ANIMALS OR NOXIOUS PLANTS
- A01M2200/00—Kind of animal
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01M—CATCHING, TRAPPING OR SCARING OF ANIMALS; APPARATUS FOR THE DESTRUCTION OF NOXIOUS ANIMALS OR NOXIOUS PLANTS
- A01M23/00—Traps for animals
- A01M23/24—Spring traps, e.g. jaw or like spring traps
Definitions
- the present disclosure generally relates to compositions, devices, and methods for attracting mice.
- mice are global pests. They cause damage by soiling food, spreading allergens, diminishing yields of agricultural crops, serving as reservoirs for disease-causing pathogens, endangering island seabird colonies, and by acting as an invasive species harming indigenous fauna (Wanless et al. 2007, Angel et al. 2009). These many adverse effects have prompted ongoing efforts to trap and poison mice. However, mice can exhibit neophobia (the fear of new objects) (Brigham & Sibley 1999). The lag time for neophobic rodents to become conditioned to the presence of newly placed traps, or trap boxes containing snap traps, and to enter them greatly reduces the effectiveness of mouse control efforts.
- a composition for attracting a mouse includes one or more long-range volatiles and one or more short-range volatiles.
- the one or more long-range volatiles include butyric acid, 2-methylbutyric acid, 4-heptanone, and 3- methylbutyric acid.
- the one or more long-range volatiles are isolated, synthetic, or purified.
- a composition for attracting a mouse includes one or more long-range volatiles.
- the one or more long-range volatiles include butyric acid, 2-methylbutyric acid, 4-heptanone, and 3-methylbutyric acid.
- the one or more long- range volatiles are isolated, synthetic, or purified.
- a method of attracting a mouse includes providing a composition including one or more long-range volatiles and one or more short- range volatiles.
- the one or more long-range volatiles include butyric acid, 2-methylbutyric acid, 4-heptanone, and 3-methylbutyric acid.
- the one or more long-range volatiles are isolated, synthetic, or purified.
- a device for attracting a mouse includes a housing or a trap and a composition including one or more long-range volatiles and one or more short-range volatiles.
- the one or more long-range volatiles include butyric acid, 2- methylbutyric acid, 4-heptanone, and 3-methylbutyric acid.
- the one or more long-range volatiles are isolated, synthetic, or purified.
- the composition is adjacent to, or included within, the housing or the trap.
- a device for attracting a mouse includes a housing for receiving a mouse and a composition including one or more long-range volatiles and one or more short-range volatiles.
- the one or more long-range volatiles include butyric acid, 2-methylbutyric acid, 4-heptanone, and 3-methylbutyric acid.
- the one or more long-range volatiles are isolated, synthetic, or purified.
- the composition is adjacent to, or included within, the housing.
- a composition for attracting a mouse includes one or more long-range volatiles and one or more short-range volatiles.
- the one or more long-range volatiles include butyric acid, 2-methylbutyric acid, 4-heptanone, and 3- methylbutyric acid.
- the composition attracts at least 3 times more male mice than a composition including the one or more short-range volatiles that is substantially free of the one or more long-range volatiles.
- a method of attracting a mouse includes providing a composition including one or more long-range volatiles and one or more short- range volatiles.
- the one or more long-range volatiles include butyric acid, 2-methylbutyric acid, 4-heptanone, and 3-methylbutyric acid.
- the composition attracts at least 3 times more male mice than a composition including the one or more short-range volatiles that is substantially free of the one or more long-range volatiles.
- a device for attracting a mouse includes a housing or a trap and a composition including one or more long-range volatiles and one or more short-range volatiles.
- the one or more long-range volatiles include butyric acid, 2- methylbutyric acid, 4-heptanone, and 3-methylbutyric acid.
- the composition attracts at least 3 times more male mice than a composition including the one or more short-range volatiles that is substantially free of the one or more long-range volatiles.
- the composition is adjacent to, or included within, the housing or the trap.
- a device for attracting a mouse includes a housing for receiving a mouse and a composition including one or more long-range volatiles and one or more short-range volatiles.
- the one or more long-range volatiles include butyric acid, 2-methylbutyric acid, 4-heptanone, and 3-methylbutyric acid.
- the composition attracts at least 3 times more male mice than a composition including the one or more short-range volatiles that is substantially free of the one or more long-range volatiles.
- the composition is adjacent to, or included within, the housing.
- FIG. 1 depicts an example of a mouse-attracting device according to one embodiment.
- FIG. 2 depicts an example of a mouse-attracting device according to another embodiment.
- FIG. 3 depicts an example of a mouse-attracting device according to another embodiment.
- FIG. 4 depicts an example of a mouse-attracting device according to another embodiment.
- FIG. 5 depicts an example of a mouse-attracting device according to another embodiment.
- FIG. 6 depicts an example of a mouse-attracting device according to another embodiment.
- FIG. 7 depicts an example of a mouse-attracting device according to another embodiment.
- FIG. 8 depicts an example of a mouse-attracting device according to another embodiment.
- FIG. 9 depicts a graph showing the mean amount of three volatile sex pheromone components in the headspace of bedding soiled by female house mice at different ages.
- FIG. 10 depicts, top to bottom, comparative gas chromatograms of the ethyl ester derivatives of 2-methylbutyric acid, synthetic 0Sj-2-methylbutyric acid, and 2- methylbutyric acid produced by female house mice.
- FIGS. 11A and 11B depict an illustration of an experimental design for behavioral experiments on mouse capture rates.
- FIG. 12 depicts mean captures of house mice in paired traps baited either with a blend of short-range and long-range sex attractant pheromone components or the short- range sex attractant pheromone components alone as a control.
- FIG. 13 depicts mean captures of house mice in paired traps baited either with a blend of short-range and long-range sex attractant pheromone components or the long- range sex attractant pheromone components alone as a control.
- volatile refers to chemicals which rapidly emanate from a source and are readily sensed by a mouse removed from the source.
- long-range volatile or“long-range pheromone component” as used herein means chemicals with a molecular weight of about 150 Daltons or less and a boiling point of about 200 °C or less. Such compounds rapidly emanate from a source and are readily sensed by a mouse at a distance of 1 meter or greater.
- short-range volatile or“short-range pheromone component” as used herein means chemicals with a molecular weight of 250 Daltons or greater. Such compounds are detectable by a mouse at a distance of 1 meter or less.
- isolated means separated from materials with which the compound is normally associated in a native state.
- purified refers to material that has been isolated under conditions that reduce, or eliminate, the presence of unrelated materials, i. e. , contaminants, including native materials from which the material is obtained. Purified materials, substantially free of contaminants, can be 50% or more pure; 90% or more pure, or 99% or more pure. Purity can be evaluated by methods known in the art.
- mice The term“lethal” as used herein means sufficient to result in immobilization, knockdown and/or death of 50% or more, 55% or more, 60% or more, 65% or more, 70% or more, 75% or more, 80% or more, 85% or more, 90% or more, 95% or more, or 99% or more, mice.
- lethal agent means an agent that is capable of immobilizing, knocking down, and/or killing 50% or more, 55% or more, 60% or more, 65% or more, 70% or more, 75% or more, 80% or more, 85% or more, 90% or more, 95% or more, or 99% or more, mice that are exposed to, or have ingested, an appropriate dose of the lethal agents over an appropriate amount of time.
- chemosterilant means a substance that is capable of sterilizing 50% or more, 55% or more, 60% or more, 65% or more, 70% or more, 75% or more, 80% or more, 85% or more, 90% or more, 95% or more, or 99% or more, mice that are exposed to, or have ingested, an appropriate dose of the substance over an appropriate amount of time.
- mouse refers to at least one mouse of the genus Mus, including the house mouse (Mus musculus).
- the term“attractant” as used herein refers to any composition or formulation that makes attractive to a mouse or mice, a habitat, food source or other site which may be frequented or traversed by a mouse or mice.
- the term“sex attractant pheromone component” as used herein refers to compounds that are naturally produced by mice and that make any composition or formulation attractive to a mouse or mice, a habitat, food source or other site which may be frequented or traversed by a mouse or mice.
- a sex attractant pheromone component may be in natural or synthetic form.
- sex attractant pheromone blend refers to a composition or formulation that contains two or more sex attractant pheromone components.
- the present disclosure generally relates to compositions for attracting at least one mouse such as a male mouse.
- the compositions can include one or more long- range volatiles.
- the long-range volatiles can enhance male mouse attraction either alone, or in combination with other known mouse attractants such as the short-range volatile steroids progesterone and estradiol.
- suitable long-range volatiles for the attraction of male mice can be produced only by female mice.
- the long-range volatiles can convey“female scent” (e.g., the presence of a female) but not the sexual maturity or receptivity of a female.
- the long-range volatiles described herein can enhance the attraction rate of male mice by orientating mice over long distances to the compositions described herein.
- short-range volatiles such as the steroidal-type mouse attractants
- the steroidal-type mouse attractant progesterone has a molecular weight of 314 Da
- the steroidal-type mouse attractant estradiol (estrogen) has a molecular weight of 272 Da.
- estradiol estradiol
- long-range volatiles can significantly increase the rate of male mouse attraction.
- the rate of attraction for a composition including both long-range volatiles and short-range volatiles can result in a superior increase in the rate of male mouse attraction, resulting in an unexpected synergy when combining such volatiles.
- a combination of long-range volatiles and short-range volatiles can increase the attraction rate of male mice by about 3 times, in certain embodiments, about 4 times, in certain embodiments, about 5 times, and in certain embodiments, about 6 times or more.
- the long-range volatiles described herein can include butyric acid, 2-methylbutyric acid, 4-heptanone, and 3-methylbutyric acid.
- the compositions described herein can include one, two, three, or more of the long-range volatiles.
- the compositions described herein can include butyric acid, 2-methylbutyric acid, and 4-heptanone.
- the long-range volatiles can be isolated, purified, and/or synthetic in various embodiments.
- the one or more volatiles can include optical isomers.
- the compositions can include racemic volatiles, such as racemic 2-methylbutyric acid, in certain embodiments.
- the one or more long-range volatiles can be included in a composition in amounts where the composition substantially emanates amounts of the long-range volatiles similar to those emanating from soiled bedding of a female mouse in a predetermined period of time.
- the one or more long-range volatiles can be included in a blend formulated to include butyric acid in about 91% by weight of the long-range volatiles, 2-methylbutyric acid in about 9% by weight of the long-range volatiles, and 4-heptanone in about 0.3% by weight of the long-range volatiles. From such blends, each of the long-range volatiles can emanate in amounts substantially similar to the amounts emanating from soiled bedding of one female mouse over 24 hours.
- compositions can include the one or more long- range volatiles in amounts such that the compositions release each of the long-range volatiles in amounts substantially similar to the amounts emanating from soiled bedding of one or more female mice over other time periods.
- certain compositions can release each of the long-range volatiles in amounts substantially similar to the amounts emanating from soiled bedding of two or more female mice over 48 hours in certain embodiments.
- a composition can include a blend of the long- range volatiles including about 2.8 mg of butyric acid, about 0.28 mg of 2-methylbutyric acid, and about 0.1 mg of 4-heptanone.
- larger amounts of the long- range volatiles can emulate the presence of two or more female mice or the sustained presence of one female mouse, for example.
- excessive amounts of the long-range volatiles may be ineffective if the long-range volatiles emanate in quantities substantially different from those associated with any gathering of feral female mice.
- a composition includes one or more long-range volatiles, one or more short-range volatiles, and one or more lethal agent(s) and chemosterilant(s).
- Suitable short-range volatiles can generally include steroidal volatiles such as progesterone and estradiol (estrogen).
- the lethal agent can be a chemical that is capable of causing immobilization and/or death of one or more mice.
- the chemical can be one or more of an anticoagulant and/or a toxicant.
- suitable lethal agents can include warfarin ((RS)-4- hydroxy-3-(3-oxo-l-phenylbutyl)- 2//-chromen-2-one).
- chlorophacinone (2-[2-(4- chlorophenyl)-l-oxo-2-phenylethyl]indane-l,3-dione), diphacinone (2-(diphenylacetyl)- li/-indene-l ,3(2F/)-dione), bromadiolone (3-[3-[4-(4-bromophenyl)phenyl] -3-hydroxy-l - phenylpropyl]-2-hydroxychromen-4-one), difethialone (3-[3-[4-(4-bromophenyl)phenyl]- l-tetralinyl] -2-hydroxy -4-thiochromenone), brodifacoum (3-[3-[4-(4- bromophenyl)phenyl] - 1 ,2,3,4-tetrahydronaphthalen- 1 -yl] -2-hydroxychromen-4-one), and combinations
- suitable toxicants can include bromethalin (/V-methyl-2,4-dinitro-6-(trifluoromethyl)-/V-(2',4',6'- tribromophenyl)aniline), cholecalciferol ((3b.5Z.7L)-9.10-secocholesta-5.7.1 ()( 19)-trien- 3-ol), zinc phosphide (zinc phosphide/trizinc diphosphide), strychnine (strychnidin-lO- one), and combinations thereof.
- the chemosterilant can be a chemical that is capable of sterilizing one or more mice.
- suitable chemosterilant chemicals can generally be compounds that can sterilize male mice as known in the art.
- Male chemosterilants can be desired due to the attraction of male mice to the long-range volatiles described herein.
- the described compositions can further include a food bait.
- Suitable food baits can include natural foodstuffs such as meat, cheese, eggs, nuts, and/or grains.
- a food bait can include lard and cracklings, cereal flour (e.g., oat flour and/or rice flour), cereal bran (e.g., wheat bran), gelling agent(s) (e.g., gelatin and/or agar), sugar (e.g., fructose), oil(s) (e.g., safflower oil), emulsifier(s) (e.g., soy lecithin) and humectant(s) (e.g., carrageenan gum powder), water, chemical attractants (e.g., 2-hydroxy-3-methylcyclopent-2-en-l-one, 2,3-butadione, 3-methylbutanal, 5- methyl-(A ’ )-2-hepten-4-one. 5-methyl-4-h
- compositions can also, or alternatively, include other components.
- natural or artificial flavorings such as milk flavor and sodium chloride can be included in certain embodiments.
- preservatives can also be included.
- sodium chloride can act as both a flavoring and as a preservative.
- bittering compounds such as denatonium benzoate
- denatonium benzoate can be included to make the compositions unpalatable to humans.
- it can also be useful to formulate the compositions with rheology modifiers, waxes and the like to modify the consistency of the compositions described herein to facilitate their use.
- the compositions can be colored through inclusion of a colorant.
- a colorant for example, dyes and pigments as known in the art can be used to color the compositions.
- colorants can be used to give the compositions a color, such as red, that provides visual warning to humans that the composition contains a potentially harmful substance such as a lethal agent.
- colorants can alternatively color a composition to a natural color.
- the compositions described herein can be used to attract one or more mice.
- the composition can be used as a bait, and, can optionally be included in a trap.
- a composition consisting essentially of one or more long-range volatiles can be used to attract one or more mice.
- a composition including one or more long-range volatiles, one or more short-range volatiles, and optionally other components can be used to attract one or more mice.
- a composition including one or more long-range volatiles and, optionally one or more short-range volatiles, in an amount of about 1% to about 99% of the composition can be used to attract one or more male mice.
- the one or more long-range volatiles and one or more short-range volatiles can be included in an amount of about 1% or more, about 2% or more, about 5% or more, about 7.5% or more, about 10% or more, about 12.5% or more, about 15% or more, about 17.5% or more, about 20% or more, about 22.5% or more, about 25% or more, about 27.5% or more, about 30% or more, about 32.5% or more, about 35% or more, about 37.5% or more, about 40% or more, about 42.5% or more, about 45% or more, about 47.5% or more, about 50% or more, about 52.5% or more, about 55% or more, about 57.5% or more, about 60% or more, about 62.5% or more, about 65% or more, about 67
- the composition can also include at least one lethal agent in an amount of about 1% to about 99% of the composition.
- the lethal agent can be a chemical that is capable of immobilizing or killing one or more mice.
- the lethal agent(s) can be included in an amount of about 1% or more, about 2% or more, about 5% or more, about 7.5% or more, about 10% or more, about 12.5% or more, about 15% or more, about 17.5% or more, about 20% or more, about 22.5% or more, about 25% or more, about 27.5% or more, about 30% or more, about 32.5% or more, about 35% or more, about 37.5% or more, about 40% or more, about 42.5% or more, about 45% or more, about 47.5% or more, about 50% or more, about 52.5% or more, about 55% or more, about 57.5% or more, about 60% or more, about 62.5% or more, about 65% or more, about 67.5% or more, about 70% or more,
- the composition can also, or alternatively, include one or more chemosterilants in an amount of about 1% to about 99% of the composition.
- the chemosterilant(s) can be a chemical that is capable of sterilizing one or more mice.
- the chemosterilant(s) can be effective to sterilize male mice.
- the chemosterilant(s) can be included in an amount of about 1% or more, about 2% or more, about 5% or more, about 7.5% or more, about 10% or more, about 12.5% or more, about 15% or more, about 17.5% or more, about 20% or more, about 22.5% or more, about 25% or more, about 27.5% or more, about 30% or more, about
- the composition can consist essentially of butyric acid, 2-methylbutyric acid, 4-heptanone, progesterone, and estradiol (estrogen) and a lethal agent.
- a composition that attracts one or more mice can be formulated as a granule, a solid block, a gel, a powder, a paste, a liquid, an aerosolized composition, or as combinations thereof.
- the compositions described herein can be applied in any suitable manner.
- the compositions can be applied as a solid, a semi-solid, a liquid, or an aerosol using appropriate devices.
- any of the compositions described herein can be included in a device for attracting one or more mice.
- the device can include a composition including one or more long-range volatiles and, optionally, one or more short-range volatiles.
- the compositions can also optionally include one or more of a lethal agent and a chemosterilant.
- the device can include a housing for receiving at least one mouse.
- the composition can be adjacent to, or included, within the housing.
- the housing can also include a food bait that is adjacent to, or included within, the composition.
- the housing can allow a mouse to enter and leave the device after ingesting the composition.
- the housing can be configured so that a mouse can enter the device, but other animals are less likely able to enter the device.
- the housing can contain a size-restrictive entryway, and the housing can optionally include a sharp turn.
- the device can be reusable (e.g., be re-baitable) or can be a single-use device.
- the device can also include, or alternatively be, a trap.
- the trap can be an immobilizing trap (e.g., a sticky trap or a chamber trap), an impaling trap, a snap trap, an asphyxiation trap (e.g., a drowning trap, or a noose-based trap), an electrocution trap, a skull-fracturing piston trap, a catch-and-release trap, a self-resetting trap capable of multiple killings, or combinations thereof.
- an immobilizing trap e.g., a sticky trap or a chamber trap
- an impaling trap e.g., a snap trap
- an asphyxiation trap e.g., a drowning trap, or a noose-based trap
- an electrocution trap e.g., a skull-fracturing piston trap, a catch-and-release trap, a self-resetting trap capable of multiple killings, or combinations thereof.
- the device can trap, or kill, more than one mouse in certain embodiments.
- a device for attracting one or more mice can include multiple single-use traps, a plurality of chambers that can each trap one mouse, or a single chamber that can trap or kill multiple mice in various embodiments.
- Other variations to the device are also possible in certain embodiments.
- a device can automatically kill and remove a mouse in certain examples.
- a mouse can be lured into a trap housing that kills the mouse using, for example, an impaling trap, a compression trap, an asphyxiation trap, an electrocution trap, or a skull fracturing piston trap.
- the trap can reset itself releasing the mouse to fall out of both the trap housing and the device.
- such devices can kill multiple mice without human intervention.
- such devices can be mechanically powered (using e.g., a compressed gas cartridge) or can be electrically powered.
- a device for attracting mice can be a dispensing device or a dispersing device which dispenses, disseminates, releases, and/or disperses a composition as described herein using a device such as an aerosol device, a trigger sprayer device, a pump sprayer device, or the like.
- the composition in such embodiments can be an aerosolized liquid or the like.
- a device can include a housing for receiving a mouse, as well as a composition comprising one or more long-range volatiles.
- the device (100) can include a housing (110).
- the housing (110) can include composition (120), which includes additive (130).
- the housing (110) can also include at least one food bait.
- the housing (110) can also include a trap.
- the composition (120) can be included within, or adjacent to, the trap within housing (110).
- the device (100) can include a housing (110).
- the housing (110) can include composition (120), which includes additive (130) and lethal agent (140).
- housing (110) can also include at least one food bait.
- housing (110) can also include a trap.
- the composition (120) can be included within, or adjacent to, the trap within housing (110).
- the device (100) can include trap (150).
- the trap (150) can include composition (120), which includes additive (130).
- the trap (150) can also include at least one food bait.
- trap (150) can also include a housing.
- the composition (120) can be included within, or adjacent, to the housing within trap (150).
- FIG. 4 a device according to an embodiment is disclosed.
- the device (100) can include trap (150).
- the trap (150) can include composition (120), which includes additive (130) and lethal agent (140).
- trap (150) can also include at least one food bait.
- trap (150) can also include a housing.
- the composition (120) can be included within, or adjacent to, the housing within trap (150).
- the device (100) can include housing (110).
- the housing (110) can include composition (120), which includes additive (130) and chemosterilant (160).
- the housing (110) can also include at least one food bait.
- the housing (110) can also include a trap.
- the composition (120) can be included within, or adjacent to, the trap within housing (110).
- the device (100) can include trap (150).
- the trap (150) can include composition (120), which includes additive (130) and chemosterilant (160).
- trap (150) can also include at least one food bait.
- trap (150) can also include a housing.
- the composition (120) can be included within, or adjacent to, the housing within trap (150).
- the device (100) can include housing (110).
- the housing (110) can include composition (120), which includes additive (130), lethal agent (140), and chemosterilant (160).
- the housing (110) can also include at least one food bait.
- the housing (110) can also include a trap.
- the composition (120) can be included within, or adjacent to, the trap within housing (110).
- the device (100) can include trap (150).
- the trap (150) can include composition (120), which includes additive (130), lethal agent (140), and chemosterilant (160).
- the trap (150) can also include at least one food bait.
- the trap (150) can also include a housing.
- the composition (120) can be included within, or adjacent to, the housing within trap (150).
- compositions described herein can be used to attract one or more mice.
- the one or more mice can be attracted by providing any of the compositions described herein.
- the one or more mice can also be immobilized and/or killed by providing any of the compositions described herein with a lethal agent.
- the one or more mice can also be sterilized by providing any of the compositions described herein with a chemosterilant.
- the composition can be provided in a dose that can be sufficient to result in the attraction, and optionally, the sterilization, immobilization, and/or death of one or more mice.
- mice Mus musculus (strain: CD-l®), were obtained from Charles River Laboratories Ltd. (Saint-Constant, QC J5A 2E7, Canada) and cared for by Animal Care Services of Simon Fraser University (“SFU”). On arrival, mice were assigned to nine groups of five female mice each and nine groups of five male mice each. Each group was accommodated in cages (50 cm c 40 cm c 20 cm) lined with commercial com cob bedding (Anderson’s Bed o’cobs, The Andersons Inc.
- Maumee, OH 43537, USA provided with Nalgene toys, running wheels (Jaimesons Pet Food Distributers, Richmond, BC V4G 1C9, Canada), and provisioned with commercial rodent food (LabDiet® Certified Rodent Diet, LabDiet, St Louis, MO 64144, USA) as well as water ad libitum.
- the long-range volatiles emanating from urine and feces deposits of female house mice were identified using the soiled bedding of female and male mice aging from 33 days to 56 days.
- Female specific long-range volatiles were theorized to act as sex attractant pheromone components.
- urine- and feces-soiled bedding from nine groups of five females each, and nine groups of five males each, were collected and replaced with fresh bedding at three-day intervals.
- GC-MS coupled gas chromatography mass spectroscopy
- the GC-MS instrument was fitted with a DB-5 MS GC column (30 m c 0.25 mm ID; Agilent Technologies Inc., Santa Clara, CA 95051, USA) using helium as the carrier gas (35 cm per second), and run using the following temperature program: 40 °C for 5 min, 10 °C per min until 280 °C (5 min).
- the injector port was set at 250 °C and the ion trap at 200 °C.
- Odorants were identified by comparing their retention indices (relative to straight chain alkanes) and mass spectra with those of authentic standards purchased from suppliers or synthesized in the laboratory. Volatiles that were either female-specific or increased in abundance as females progressed to sexual maturity were considered candidate sex attractant pheromone components.
- Table 1 depicts the volatiles identified in the soiled bedding of female and male mice.
- odorants comprising acids, ketones, alcohols, sesquiterpenes as well as sulfur- and nitrogen-containing compounds that varied greatly in relative abundance.
- four volatiles were female-specific: butyric acid, 2-methylbutyric acid, 3-methylbutyric acid, and 4-heptanone. While these components differed in absolute amounts, the relative abundance of butyric acid, 2- methylbutyric acid, and 4-heptanone did not increase as female mice progressed from juveniles to adults as depicted in FIG. 9.
- Gas chromatogratographic-mass spectrometric analyses can be used to determine the amount of long-range volatiles emanating from the soiled bedding of a female mouse over a period of time. Specifically, by comparing the peak area integrations of the long- range volatiles to the peak area integration of an internal standard (e.g., dodecyl acetate) in a gas chromatogram of soiled bedding headspace volatiles from a female house mouse over a selected period of time, the amount of the each of the long-range volatiles emanating from the soiled bedding can be determined.
- an internal standard e.g., dodecyl acetate
- each trap box, labeled 1 contained a snap trap (M325 M7 Pro mouse Woodstream Co., Lititz, PA 175543, USA), labeled 2, that was baited with the food bait used in PCT Patent App. No. PCT/CA2017/050498.
- Each of the trap boxes further included a triangular piece of filter paper, (Whatman #1, 120 mm, Maidstone, England, 01622), labeled 3, that was treated with a blend of the known short-range pheromone components progesterone (250 ng) and estradiol (125 ng) dissolved in 50 pl of ether.
- Each of the trap boxes was randomly assigned a control or treatment stimulus contained in a 400-m1 polyethylene microcentrifuge tube (Evergreen Scientific, 18704 South Ferris Place, Collinso Dominguez, CA 90220), labelled 4, with a pierced (1.5 mm) lid.
- the treatment microcentrifuge tube contained a blend of the long-range candidate pheromone componentsconsisting of 2.8 mg of butyric acid, 0.28 mg of 2-methylbutyric acid, and 0.1 mg of 4-heptanone formulated in 200-m1 of mineral oil.
- the ratio and release rates of the blend of long-range candidate pheromone components were equivalent to those emanating from the soiled bedding of one female over 24 hours.
- the microcentrifuge tube in the conesponding control trap box contained 200 m ⁇ of mineral oil.
- Out of 46 adult males captured, 40 were captured in traps baited with the long-range volatile sex attractant pheromone blend.
- the probability of capturing a mouse of a particular age or sex differed based on the trap lure (logistic regression analysis; Tukey’s test for multiple comparisons of trapping probabilities; P ⁇ 0.05).
- Tukey logistic regression analysis
- the probability of capturing adult males and juvenile males was 0.87 and 0.83, respectively, whereas the probability of capturing adult females and juvenile females was 0.63 and 0.37, respectively.
- Experiment 1 illustrate the synergistic effect of the blend of long- range sex attractant pheromone components and short-range sex attractant pheromone components on the capture rate of juvenile and adult male house mice.
- traps baited with a blend of progesterone and estradiol (estrogen) alone afforded captures of adult male house mice and juvenile male house mice 9-fold and 21- fold, respectively (see, e.g., PCT Patent App. No. PCT/CA2017/050618), greater than those in traps lacking any pheromone lure.
- the present trap lure combination of the short-range pheromone components progesterone and estradiol (estrogen) with the present blend of long-range volatiles resulted in a further 6.6 fold and 4.7 fold increase in the capture rate of adult male house mice and juvenile male house mice, respectively.
- a second field experiment was performed to test the ability of the short-range pheromone components progesterone and estradiol to enhance the attractiveness of the long-range sex attractant pheromone components butyric acid, 2-methylbutyric acid, and 4-heptanone.
- the design was identical to that of Experiment 1 except that both trap boxes in each pair (31 replicates) were baited with the long-range sex attractant pheromone components but only the treatment trap box received progesterone and estradiol.
- % percent by weight of the total composition, also expressed as weight/weight %, % (w/w), w/w, w/w % or simply %, unless otherwise indicated.
- wet refers to relative percentages of the composition in a dispersion medium (e.g., water); and“dry” refers to the relative percentages of the dry composition prior to the addition of the dispersion medium. In other words, the dry percentages are those present without taking the dispersion medium into account.
- Wet admixture refers to the composition with the dispersion medium added.“Wet weight percentage”, or the like, is the weight in a wet mixture; and“dry weight percentage”, or the like, is the weight percentage in a dry composition without the dispersion medium. Unless otherwise indicated, percentages (%) used herein are dry weight percentages based on the weight of the total composition.
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- General Health & Medical Sciences (AREA)
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- Agronomy & Crop Science (AREA)
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Abstract
Description
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AU2019264158A AU2019264158A1 (en) | 2018-05-04 | 2019-05-03 | Attractants for mice |
MX2020011553A MX2020011553A (en) | 2018-05-04 | 2019-05-03 | Attractants for mice. |
CA3098728A CA3098728A1 (en) | 2018-05-04 | 2019-05-03 | Attractants for mice |
EP19796028.9A EP3796780A4 (en) | 2018-05-04 | 2019-05-03 | Attractants for mice |
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US201862667376P | 2018-05-04 | 2018-05-04 | |
US62/667,376 | 2018-05-04 |
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PCT/CA2019/050586 WO2019210423A1 (en) | 2018-05-04 | 2019-05-03 | Attractants for mice |
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US (1) | US20190335740A1 (en) |
EP (1) | EP3796780A4 (en) |
AU (1) | AU2019264158A1 (en) |
CA (1) | CA3098728A1 (en) |
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WO2022066785A1 (en) | 2020-09-23 | 2022-03-31 | Oms Investments, Inc. | Mouse repellents, devices, and methods of using such |
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US20220046917A1 (en) * | 2020-08-17 | 2022-02-17 | Elana VARNER | Attractant blend compositions, devices and methods for attracting female mice |
Citations (2)
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WO2017096485A1 (en) * | 2015-12-09 | 2017-06-15 | Gerhard Gries | Compositions and methods for attacting rattus norvegicus rats comprising pheromone compounds from headspace volatiles of male or female urine odor |
WO2017201614A1 (en) * | 2016-05-23 | 2017-11-30 | Gerhard Gries | Compositions and methods comprising pheromone compounds androstenone, testosterone, progesterone and estrogen |
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DE29709475U1 (en) * | 1997-05-30 | 1997-09-25 | Preska, Robert, 44534 Lünen | Boar attractant |
DE29709474U1 (en) * | 1997-05-30 | 1997-09-25 | Preska, Robert, 44534 Lünen | Fox attractant for males |
-
2019
- 2019-05-02 US US16/401,673 patent/US20190335740A1/en active Pending
- 2019-05-03 AU AU2019264158A patent/AU2019264158A1/en not_active Withdrawn
- 2019-05-03 MX MX2020011553A patent/MX2020011553A/en unknown
- 2019-05-03 EP EP19796028.9A patent/EP3796780A4/en active Pending
- 2019-05-03 CA CA3098728A patent/CA3098728A1/en active Pending
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2017096485A1 (en) * | 2015-12-09 | 2017-06-15 | Gerhard Gries | Compositions and methods for attacting rattus norvegicus rats comprising pheromone compounds from headspace volatiles of male or female urine odor |
WO2017201614A1 (en) * | 2016-05-23 | 2017-11-30 | Gerhard Gries | Compositions and methods comprising pheromone compounds androstenone, testosterone, progesterone and estrogen |
Non-Patent Citations (4)
Title |
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See also references of EP3796780A4 * |
TAKACS, S. ET AL.: "New food baits for trapping house mice, black rats and brown rats", APPLIED ANIMAL BEHAVIOR SCIENCE, vol. 200, no. 2018, 2 December 2017 (2017-12-02), pages 130 - 135, XP055648747 * |
TAKACS, S. ET AL.: "Sex Hormones Function as Sex Attractant Pheromones in House Mice and Brown Rats", CHEMBIOCHEM COMMUNICATIONS, vol. 18, 8 June 2017 (2017-06-08), pages 1391 - 1395, XP055648751 * |
VARNER, E. ET AL.: "Identification and Field Testing of Volatile Components in the Sex Attractant Pheromone Blend of Female House Mouse", JOURNAL OF CHEMICAL ECOLOGY, vol. 45, 9 November 2018 (2018-11-09), pages 18 - 27, XP036671905, DOI: 10.1007/s10886-018-1032-3 * |
Cited By (1)
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WO2022066785A1 (en) | 2020-09-23 | 2022-03-31 | Oms Investments, Inc. | Mouse repellents, devices, and methods of using such |
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EP3796780A1 (en) | 2021-03-31 |
AU2019264158A1 (en) | 2020-12-03 |
EP3796780A4 (en) | 2021-07-07 |
MX2020011553A (en) | 2021-01-29 |
US20190335740A1 (en) | 2019-11-07 |
CA3098728A1 (en) | 2019-11-07 |
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