WO2019207554A4 - Extraction of compounds from cannabis biomass using food-grade solvent - Google Patents
Extraction of compounds from cannabis biomass using food-grade solvent Download PDFInfo
- Publication number
- WO2019207554A4 WO2019207554A4 PCT/IB2019/053466 IB2019053466W WO2019207554A4 WO 2019207554 A4 WO2019207554 A4 WO 2019207554A4 IB 2019053466 W IB2019053466 W IB 2019053466W WO 2019207554 A4 WO2019207554 A4 WO 2019207554A4
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- carrier fluid
- oil
- slurry
- biomass
- continuous flow
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0211—Solvent extraction of solids in combination with an electric or magnetic field
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0288—Applications, solvents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0292—Treatment of the solvent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0215—Solid material in other stationary receptacles
- B01D11/0223—Moving bed of solid material
- B01D11/0226—Moving bed of solid material with the general transport direction of the solids parallel to the rotation axis of the conveyor, e.g. worm
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Botany (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Plant Substances (AREA)
- Extraction Or Liquid Replacement (AREA)
- Fats And Perfumes (AREA)
Abstract
A method of extracting pharmacologically active compounds from cannabis biomass is disclosed. The method comprises providing a raw biomass containing target compounds. Slurry is prepared by adding a solvent to the prepared biomass. In a preferred embodiment, the solvent may be a medium-chain triglyceride, such as coconut oil, or an edible and food-grade solvent or emulsifier used to standardize active compounds in pharmaceutical, nutraceutical, functional food, or cosmetic formulations. In some embodiments, the solvent may be a polyunsaturated fatty acid (PUFA), com oil, safflower oil, borage oil, flax oil, canola oil, cottonseed oil, soybean oil, olive oil, sunflower oil, monoglycerides, diglycerides, triglycerides, lecithin, limonene, essential oils of spices, herbs or other plants, fish oil, glycerol, glycols, or any other, or mixtures thereof. Various pharmacologically active compounds could be extracted from the slurry by processing in a continuous flow extractor. Successively, the solvent containing various pharmacologically active compounds may be separated from a spent biomass.
Claims
1. A method of extracting pharmacologically active compounds from a biomass, the method comprising:
preparing raw cannabis biomass, wherein the prepared cannabis biomass comprises particles;
adding a carrier fluid to the prepared cannabis biomass to form a slurry, wherein the added carrier fluid includes a food-grade solvent;
extracting target compounds from the slurry using a continuous flow extraction apparatus, wherein extracting the target compounds includes conveying a continuous flow of the slurry into an extraction chamber and heating the continuous flow of slurry within the extraction chamber, and wherein the target compounds comprise cannabinoids and terpenes; and
separating a spent biomass from the carrier fluid by a downstream process, wherein the separated carrier fluid now further includes the extracted target compounds.
2. The method of claim 1, wherein preparing the raw cannabis biomass comprises at least one of milling, grinding, or sorting plant matter in the raw cannabis biomass into the particles.
3. The method of claim 1, wherein the carrier fluid includes at least one of medium chain triglyceride, polyunsaturated fatty acid, corn oil, safflower oil, borage oil, flax oil, canola oil, cottonseed oil, soybean oil, olive oil, sunflower oil, monoglycerides, di glycerides, triglycerides, lecithin, limonene, essential oils of spices, herbs or other plants, fish oil, glycerol, and glycols.
2
4. The method of claim 1, wherein the downstream process comprises at least one of concentration, separation, isolation, and formulation.
5. The method of claim 1, further comprising combining the separated carrier fluid with a new raw cannabis biomass to form a new slurry.
6. The method of claim 1, further comprising analyzing the separated carrier fluid, and generating a cannabinoid profile based on the analysis, the cannabinoid profile identifying a plurality of different cannabinoids within the analyzed carrier fluid, each different cannabinoid associated with an identified concentration.
7. The method of claim 6, further comprising recirculating the separated carrier fluid to combine with a new raw cannabis biomass to form a new slurry until a desired profile is reached.
8. The method of claim 1, wherein heating the continuous flow of slurry includes exposing the continuous flow of the slurry to microwave energy via a microwave- transparent portion of the extraction chamber.
9. The method of claim 8, wherein the slurry is heated to at least a melting point temperature of the carrier fluid.
10. The method of claim 8, wherein heating the continuous flow of slurry comprises applying the microwave energy from a microwave generator.
11. The method of claim 1, further comprising decarboxylating the separated carrier fluid.
12. The method of claim 11, wherein decarboxylating the separated carrier fluid comprises subjecting the separated carrier fluid to controlled decarboxylation in
3
accordance with a desired level of conversion of the cannabinoids to one or more neutral forms.
13. The method of claim 1, wherein the carrier fluid is further pharmaceutical-grade or cosmetics-grade.
14. The method of claim 1, wherein the carrier fluid further includes an organic solvent mixed with the food-grade solvent.
15. A system of extracting pharmacologically active compounds from a biomass, the system comprising:
a biomass preparation chamber where raw cannabis biomass is prepared, wherein the prepared cannabis biomass comprises particles;
a slurry formation chamber that receives the prepared cannabis biomass from the biomass preparation chamber, wherein a carrier fluid is added to the prepared cannabis biomass to form a slurry, wherein the added carrier fluid includes a food-grade solvent; a continuous flow extraction apparatus that includes an extraction chamber into which a continuous flow of the slurry is conveyed and heated to extract the target compounds from the slurry, wherein the target compounds comprise cannabinoids and terpenes; and
a separation chamber that separates a spent biomass from the carrier fluid by a downstream process, wherein the separated carrier fluid now further includes the extracted target compounds.
16. The system of claim 15, wherein the biomass chamber prepares the raw cannabis biomass by at least one of milling, grinding, or sorting plant matter in the raw cannabis biomass into the particles.
17. The system of claim 15, wherein the carrier fluid includes at least one of medium chain triglyceride, polyunsaturated fatty acid, corn oil, safflower oil, borage oil, flax oil,
4
canola oil, cottonseed oil, soybean oil, olive oil, sunflower oil, monoglycerides, di glycerides, triglycerides, lecithin, limonene, essential oils of spices, herbs or other plants, fish oil, glycerol, and glycols.
18. The system of claim 15, wherein the downstream process comprises at least one of concentration, separation, isolation, and formulation.
19. The system of claim 15, further comprising a conveyor that recirculates the separated carrier fluid to combine with a new raw cannabis biomass and form a new slurry.
20. The system of claim 15, further comprising a sampling chamber that analyzes the separated carrier fluid, and generates a cannabinoid profile based on the analysis, the cannabinoid profile identifying a plurality of different cannabinoids within the analyzed carrier fluid, each different cannabinoid associated with an identified concentration.
21. The system of claim 20, further comprising a conveyor that recirculates the separated carrier fluid to combine with a new raw cannabis biomass to form a new slurry until a desired profile is reached.
22. The system of claim 15, wherein the extraction chamber includes a microwave- transparent portion, and wherein the continuous flow of slurry is heated by exposing the continuous flow of the slurry to microwave energy via the microwave-transparent portion.
23. The system of claim 22, wherein the slurry is heated to at least a melting point temperature of the carrier fluid.
24. The system of claim 22, further comprising a microwave generator that generates the microwave energy, wherein the microwave generator heats the slurry by applying the microwave energy from the microwave generator.
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25. The system of claim 15, wherein the separated carrier fluid is further decarboxylated.
26. The system of claim 25, wherein decarboxylating the separated carrier fluid comprises subjecting the separated carrier fluid to controlled decarboxylation in accordance with a desired level of conversion of the cannabinoids to one or more neutral forms.
27. The system of claim 15, wherein the carrier fluid is further pharmaceutical-grade or cosmetics-grade.
28. The system of claim 15, wherein the carrier fluid further includes an organic solvent mixed with the food-grade solvent.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862663540P | 2018-04-27 | 2018-04-27 | |
| US62/663,540 | 2018-04-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2019207554A1 WO2019207554A1 (en) | 2019-10-31 |
| WO2019207554A4 true WO2019207554A4 (en) | 2019-12-19 |
Family
ID=67770537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IB2019/053466 WO2019207554A1 (en) | 2018-04-27 | 2019-04-27 | Extraction of compounds from cannabis biomass using food-grade solvent |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2019207554A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230219015A1 (en) * | 2020-08-26 | 2023-07-13 | K.D. Pharma Bexbach Gmbh | Extraction method and mixture of substances |
| LU102018B1 (en) * | 2020-08-26 | 2022-02-28 | K D Pharma Bexbach Gmbh | Extraction process and mixture of substances |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8445034B1 (en) * | 2010-11-02 | 2013-05-21 | Albert L Coles, Jr. | Systems and methods for producing organic cannabis tincture |
| CA2780578A1 (en) * | 2012-06-19 | 2013-12-19 | Radient Technologies Inc. | Method for direct extraction and concentration of naturally-derived active compounds |
| RU2659778C1 (en) * | 2013-11-11 | 2018-07-04 | Зэ Верк Шоп, Ллс | Processing, system and methods without application of solvent |
| US9808494B2 (en) * | 2015-01-22 | 2017-11-07 | Rm3 Labs, Llc | Process for the extraction of cannabinoids from cannabis using lipids as an extraction solvent |
| US10143706B2 (en) * | 2016-06-29 | 2018-12-04 | Cannscience Innovations, Inc. | Decarboxylated cannabis resins, uses thereof and methods of making same |
| IL248150B (en) * | 2016-09-29 | 2018-05-31 | Garti Nissim | Method for selective extraction of cannabinoids from a plant source |
| US20180343812A1 (en) * | 2017-05-31 | 2018-12-06 | Insectergy, Llc | Cannabis farming systems and methods |
| CA3103178A1 (en) * | 2017-06-27 | 2019-01-03 | Enviro BioMedical Laboratories Inc. | Blended cannabis compounds and methods of making the same |
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2019
- 2019-04-27 WO PCT/IB2019/053466 patent/WO2019207554A1/en active Application Filing
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| Publication number | Publication date |
|---|---|
| WO2019207554A1 (en) | 2019-10-31 |
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