WO2019200198A1 - Dispositif d'injection automatique comprenant un système d'entraînement magnétique - Google Patents

Dispositif d'injection automatique comprenant un système d'entraînement magnétique Download PDF

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Publication number
WO2019200198A1
WO2019200198A1 PCT/US2019/027136 US2019027136W WO2019200198A1 WO 2019200198 A1 WO2019200198 A1 WO 2019200198A1 US 2019027136 W US2019027136 W US 2019027136W WO 2019200198 A1 WO2019200198 A1 WO 2019200198A1
Authority
WO
WIPO (PCT)
Prior art keywords
injection device
automatic injection
drug container
magnet
stopper
Prior art date
Application number
PCT/US2019/027136
Other languages
English (en)
Inventor
Eyal BARMAIMON
Lior Shtram
Boaz KALISCH
Ronny BELLAN
Nadav Cohen
Shai Finkman
Yuval Harel
Original Assignee
Flextronics Ap, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/951,425 external-priority patent/US10967118B2/en
Application filed by Flextronics Ap, Llc filed Critical Flextronics Ap, Llc
Publication of WO2019200198A1 publication Critical patent/WO2019200198A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A61M2005/14252—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type with needle insertion means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
    • A61M2005/16863—Occlusion detection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3317—Electromagnetic, inductive or dielectric measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic

Definitions

  • Injection devices are used to deliver pharmaceutical products such as biologies and medications to a patient (i.e., a person or animal).
  • a syringe and needle is an example of a widely- used injection device.
  • This basic system typically involves a person manually moving a stopper portion of the syringe to force the pharmaceutical product through the needle and into the patient.
  • Other injection devices have been developed to deliver pharmaceutical products automatically at the touch of a button or the actuation of a switch. These devices are advantageous in that they allow a patient to more easily self-administer the pharmaceutical product.
  • some automatic injection devices allow for slow or periodic delivery of the pharmaceutical product as needed, which is typical procedure for patients dependent on insulin injections, for example.
  • the present disclosure is directed to an automatic injection device which addresses these needs and the associated problems of the prior art.
  • the present disclosure is directed to an automatic injection device.
  • the automatic injection device includes an insertion needle configured to be inserted into a patient and a drug container which contains a pharmaceutical product.
  • the drug container includes a stopper.
  • the automatic injection device also includes a fluid path which fluidly connects the drug container to the insertion needle.
  • the automatic injection device further includes a drive system configured to cause linear movement of the stopper to force the pharmaceutical product into the fluid path.
  • the drive system includes a driving element and a movable element.
  • the automatic injection device additionally includes electronics configured to provide a signal to the drive system to move the stopper and to monitor its position.
  • the movable element includes an outer magnet at least partially surrounding the drug container and an inner magnet inside the drug container.
  • the present disclosure is directed to a method of assembling an automatic injection device.
  • the method includes positioning a diametrically magnetized inner magnet in a drug container which contains a pharmaceutical product and inserting the drug container in a through-hole of a diametrically magnetized outer magnet such that the inner magnet is aligned with the through-hole.
  • the outer magnet is linearly movable on an outside of the drug container by a driving element of the automatic injection device in order to move the inner magnet inside the drug container.
  • FIG. 1 is a side view illustration of an exemplary automatic injection device positioned on a patient
  • FIG. 2 is a schematic illustration of the components of an automatic injection device consistent with disclosed embodiments
  • FIG. 3 is a perspective view of a top side of the automatic injection device
  • FIG. 4 is a perspective view of a bottom side of the automatic injection device
  • Fig. 5 is a perspective view of the internal components according to an embodiment of the automatic injection device
  • Fig. 6 is a perspective view of a moveable element
  • Fig. 7 is a perspective view of a driving element
  • FIG. 9 is a perspective view of a movable element of a drive system in a first position
  • Fig. 10 is a perspective view of the movable element of the drive system in a second position.
  • Disclosed embodiments pertain to a drive system for an automatic injection device.
  • the drive system provides an input force to move an element of the automatic injection device to control delivery of a pharmaceutical product to a patient.
  • the drive system is also configured to control movement of a stopper placed in a drug container. Further movement of the stopper inside the drug container pushes the pharmaceutical product through a fluid path and to an insertion needle which connects to the patient. This controlled movement of the stopper allows for metered delivery of the pharmaceutical product according to desired parameters.
  • the disclosed drive system includes features which allow for precise close loop control over stopper movement and location while providing a small form factor which allows the automatic injection device to be compact.
  • the disclosed drive system utilizes magnetic elements which harness a magnetic force to create a connection between an element outside of the drug container and an element inside the drug container and also serve as a position sensor. This configuration can be provided in a small space and also does not require the drive element to physically enter the drug container to push the stopper.
  • Fig. 1 is a depiction of an exemplary embodiment of an automatic injection device
  • the patient 10 is not limited and can be any organism which may receive an injection.
  • the device 12 is configured to deliver a pharmaceutical product to the patient 10 automatically. This means that the device 12 is controlling the injection in some way such that the system differs from other injection systems where manual input alone causes the injection (i.e., a conventional syringe and needle system or other available systems).
  • the automatic aspect of the device 12 may additionally or alternatively relate to the duration of the injection, controlled injection intervals, a delay between input and injection, etc.
  • the device 12 includes a base 14 that contacts the patient’s skin.
  • the device 12 includes an insertion needle 16 which enters the patient 12 to deliver a pharmaceutical product, such as insulin, to the patient.
  • a pharmaceutical product such as insulin
  • An example of an automatic injection device which includes many of the features that may be incorporated into the device 12 is described in WO 2017/007952, which is herein incorporated by reference. However, it should be understood that the device 12 is not limited to the automatic injection device described therein or the exemplary embodiments described below.
  • An automatic injection device consistent with this disclosure may include some of the features described herein but is not limited thereto. For example, a disclosed automatic injection device may resemble a syringe and needle system or other injection system which is adapted for automatic injections via the features described herein.
  • Fig. 2 is a schematic illustration of the automatic injection device 12 and the basic features of the device 12 which facilitate automatic injections of a pharmaceutical product into the patient 10.
  • the device 12 preferably includes a housing 18 which holds at least some of the features of the device 12.
  • these features preferably include a drug container 20, a fluid path 22, a drive system 24, and electronics 26. These features work in conjunction with each other to automatically deliver a pharmaceutical product to the patient 10 according to desired parameters.
  • the drug container 20 is a containing element which supplies the pharmaceutical product.
  • the drug container 20 may be a vial, syringe, or the like and includes a space for containing the pharmaceutical product, which is not limited to a particular substance.
  • the pharmaceutical product may be any substance which is considered one or more of a drug, biologic, medication, or placebo, for example.
  • the drug container 20 is preferably a hollow cylindrical tube which receives the pharmaceutical product. However, it should be understood that other configurations are possible.
  • the drug container 20 is fluidly connected to the insertion needle
  • the fluid path 22 may be a physical connecting channel which serves as a conduit for delivering the pharmaceutical product from the drug container 20 to the insertion needle 16 and ultimately into the patient 10.
  • the fluid path 22 may include additional structure, including actuating mechanisms which initiate delivery of the pharmaceutical product and/or control mechanisms which meter an amount of product which is delivered to the patient 10 at any particular time.
  • the fluid path 22 may include an element or mechanism which is configured to establish the connecting channel, such as a puncturing needle or the like.
  • the fluid path 22 may be associated with a start button or control switch or even the electronics 26 which control an element of the fluid path 22 (e.g., a valve) in order to start or stop the delivery of the pharmaceutical product. It should be understood, however, that the fluid path 22 may be a passive system component in at least some embodiments.
  • the drive system 24 and electronics 26 provide the automatic aspect of the injections via device 12.
  • the drive system 24 is a mechanical system which physically moves an element of the device 12 to move the pharmaceutical product from the drug container 20 to into the fluid path 22 and ultimately into the patient 10.
  • the drive system 24 may be configured to move a stopper positioned inside the drug container 20 to force the pharmaceutical product out of the drug container 20.
  • the drive system 24 includes magnetic elements, as will be described in more detail herein.
  • the electronics 26 include features such as control and sensing circuitry, processing devices, memory, I/O devices, etc. and are configured to control the drive system 24 such that the pharmaceutical product is delivered according to desired parameters.
  • the electronics may translate an input signal and provide a signal to the drive system 24 to move a stopper inside the drug container 20 by a selected amount.
  • Figs. 3 and 4 further illustrate an exemplary embodiment of the automatic injection system 12.
  • Fig. 3 illustrates a first side of the device 12, including the housing 18 which rests on top of the base 14.
  • the housing 18 is illustrated as being rectangular, but can include any shape.
  • the housing 18 may include optional features such as at least one control switch 28 which provides an input signal to the electronics 26 and/or a window 30 which provides a view of the drug container 20 and thus the current fluid level.
  • Fig. 4 illustrates a second side of the device 12 including a bottom surface of the base 14.
  • the bottom surface 32 includes an opening 34 for receiving the insertion needle 16 there through.
  • the device 12 is placed against the patient 10 with the bottom surface 32 of the base 14 against the skin.
  • An injection needle extends through the opening 34 and into the patient 10 to deliver the pharmaceutical product.
  • the bottom surface 32 may include an adhesive material thereon to adhere the device 12 to the patient 10 for either a short or long period of time, depending on the particular use of the device 12.
  • Fig. 5 illustrates the device 12 with the top portion of the housing 18 removed such that the internal features are shown in an enclosed space 36 formed by a lower portion of the housing 18 and the base 14.
  • the device 12 includes exemplary embodiments of the insertion needle 16, the drug container 20, the fluid path 22, the drive system 24, and the electronics 26.
  • the enclosed space 36 houses at least the drug container 20, drive system 24, and electronics 26 such that the elements are positioned inside of the housing 18.
  • the fluid path 22 in this embodiment includes a drug container needle 38 which physically connects to the drug container 20 to establish a connection channel between the interior of the drug container 20 and the insertion needle 16.
  • the insertion needle 16 is positioned perpendicular to the drug container 20 such that the path of the pharmaceutical product is to travel out of the drug container 20 and laterally into the area of the insertion needle 16 via the fluid path 22. The pharmaceutical product subsequently travels vertically downward through the insertion needle 16 and into the patient 10.
  • This configuration is exemplary, however, and disclosed embodiments are not limited thereto.
  • the insertion needle 16 may be aligned in the same direction as the drug container 20 and/or the fluid path 22.
  • the drive system 24 includes a driving element 40 and a movable element 42.
  • the driving element 40 is positioned in the space 36 and is electronically connected to the electronics 26.
  • the driving element 40 is a device which produces mechanical motion, such as a motor or the like.
  • the movable element 42 is operably connected to the driving element 40 such that the driving element 40 controls the motion of the movable element 42.
  • the electronics 26 further includes any magnet-sensitive sensors like hall effect sensors, which are positioned along the electronic board along the stopper linear movement path (53), thus sensing the location of the magnet.
  • Fig. 6 illustrates an embodiment of a moveable element 42 where the driving element 40 includes two shafts 44 and 44A on each side of the drug container 20 and two connectors 46 and 46A which is movable on the shafts 44 and 44A by the motor 24.
  • the movable element 42 includes an outer collar 48 which surrounds the drug container 20 and which movement thereof is configured to cause the pharmaceutical product to exit the drug container 20 and enter the fluid path 22.
  • the outer magnet 58 and inner magnet 60 are configured to create a magnetic field which maintains a relative position between the two.
  • the outer magnet 58 may be diametrically magnetized with a first radial side 66 of the outer magnet 58 being a first pole and a second radial side 68 of the outer magnet being a second pole.
  • the inner magnet 60 may be diametrically magnetized in a direction opposite from the outer magnet 58.
  • the inner magnet 60 may include a first radial side 70 which is aligned with the first radial side 66 of the outer magnet 58 and which is an opposite pole of the first radial side 66 of the outer magnet 58.
  • the inner magnet 60 may include a second radial side 72 which is aligned with the second radial side 68 of the outer magnet 58 and which is an opposite pole of the second radial side 68 of the outer magnet 58.
  • the first side 66 of the outer magnet 58 is attracted to the first side 70 of the inner magnet 60 and the second side 68 of the outer magnet 58 is attracted to the second side 72 of the inner magnet 60.
  • the inner magnet 60 can be positioned in the through-hole 62 of the outer magnet 58 in equilibrium such that inner magnet 60 will follow movement of the outer magnet 58.
  • the outer magnet 58 and inner magnet 60 may be formed from any of a variety of magnetic materials (e.g., magnetized metallic materials, rare earth magnets, etc.).
  • one or more of the outer magnet 58 and/or the inner magnet 60 may be an electromagnet.
  • the outer magnet 58 may be an electromagnet which can be switched on and off (and/or reverse polarization) to control the magnetic field in and around the movable element 42.
  • the outer magnet 58 may be controllable (e.g., as an electromagnet) to selectively repel and/or attract the inner magnet 60 to cause the inner magnet 60 to move within the drug container 20.
  • Fig. 7 illustrates an embodiment of the outer collar 48 which have two threaded areas positioned alongside the shafts 44A and 44. This configuration transfers the rotational movement of the shaft into a linear movement of the outer collar 48, the outer magnet (58) and eventually the stopper (not depicted) through the magnetic force.
  • Fig. 8 illustrates a flow chart of automatic control of movement of the stopper movement.
  • the electronics 26 detects and measures a motor current during injection (801 ).
  • the electronics 26 may detect and measure the motor current via a current sensor.
  • the motor current is then compared to a preset range that may be input into the electronics prior to injection (802). If the motor current is within the range, dosing and injection continues and the stopper continues to move. If the motor current is outside of the preset range, the electronics 26 determines whether the motor current is less than the minimum preset current value or whether the motor current is greater than the maximum preset current value.
  • the electronics 26 determines that the motor is not working (805) and determines that an error has occurred (807). If the motor current is greater than the maximum preset current value, then the electronics will cease the current for 5 seconds (806). The process will then start again by driving momentary increased current for overcoming occlusion, ceasing the increased current, and then measuring the motor current again (808). If the current is less than the maximum preset current value, then dosing and injection continues and the stopper continues to move (809). If the motor current is determined, again, to be greater than the maximum preset current value, then step 806 and 808 will be repeated with 1.5 times the increased current value (810). If in the third time the measured motor currents are greater than the maximum preset current value, then an error is determined (81 1). It should be noted that the electronics 26 may utilize additional algorithms and implementations to detect and manage over current sensing.
  • Figs. 9 and 10 further illustrate the functioning of the drive system 24 in relation to the drug container 20.
  • the inner magnet 60 is positioned in the drug container 20 and abuts the stopper 56 (or acts as the stopper in alternative embodiments).
  • the outer magnet 58 is positioned around the exterior of the drug container 20, in alignment with the inner magnet 60.
  • two outer magnets 58 and two inner magnets 60 may be stacked in a longitudinal direction to establish a sufficient magnetic force between the two.
  • the outer collar 48 surrounds the outer magnet 58 (or is the outer magnet 58 in alternative embodiments).
  • the connectors 46 and 46A are positioned on the shafts 44 and 44A, which are attached to the driving element 40.
  • the driving element 40 is configured to linearly move the connectors 46 and
  • the movement of the outer magnet 58 in this way along the outside of the drug container 20 causes corresponding movement of the inner magnet 60 inside of the drug container 20.
  • the corresponding movement of the inner magnet 60 is linear movement along the longitudinal axis of the drug container 20.
  • the corresponding movement is enabled by the magnetic attraction between the inner magnet 60 and the outer magnet 58, which penetrates through the surface of the drug container 20.
  • Fig. 9 illustrates the movable element 42 of the drive system 24 in a first position, with the stopper 56 near a first longitudinal end 74 of the drug container 20.
  • the drive element 40 is configured to move the inner magnet 60 (via the outer magnet 58, outer collar 48, connectors 46 and 46A, and shafts 44 and 44A to force the stopper 56 toward a second longitudinal end 76 of the drug container 20.
  • Fig. 10 illustrates the movable element 42 of the drive system 24 in a second position, with the stopper 56 near the second longitudinal end 76 of the drug container 20. This movement of the stopper 56 forces the pharmaceutical product in the drug container out of an opening near the second longitudinal end 76 and into the fluid path 22 of the device 12. The pharmaceutical product subsequently flows through the flow path 22 and into the patient 10 through the insertion needle 16.
  • the electronics 26 are configured to control and measure the movement of the shafts 44 and 44A, connectors 46 and 46A, and/or outer collar 48 such that precise control over movement of the stopper 50 is possible.
  • the driving element 40 controls (via control and sensing signals from the electronics 26) an amount, timing, and speed of an automatic injection of a pharmaceutical product from the drug container 20 into the patient 10.
  • the driving element 40 causes parallel linear movement of the outer magnet 58 which causes linear movement of the inner magnet 60.
  • the illustrated embodiments further include the shafts 44 and 44A, connectors 46 and 46A, outer collar 48, and stopper 56 as additional components which may be included in the operative configuration. Flowever, some or all of these components may be omitted and/or substituted by similar components.
  • the driving element 40 may directly move the outer magnet 58, which moves the stopper 56 via the inner magnet 60.
  • the inner magnet 60 is configured as the stopper 56 such that movement of the inner magnet 60 directly forces the pharmaceutical product out of the drug container 20.
  • the relative orientation of the disclosed components may be varied.
  • the first longitudinal end 74 of the drug container 20 may be connected to the fluid path 22 and the stopper 56 and pharmaceutical product arranged on an opposite side of the inner magnet 60 such that driving element 40“pulls” the stopper 56 to force the pharmaceutical product out of the drug container 20.
  • the disclosed features are applicable to any injection device in order to cause movement of a stopper without physically entering the drug container.
  • the magnetic arrangement allows movement of a component outside of the drug container (e.g., the outer magnet) to cause corresponding movement of a component inside the drug container (e.g., the inner magnet) without physically breaking a barrier into the drug container.
  • This configuration is especially applicable to an automatic injection device where a driving element is present.
  • the magnetic arrangement allows the driving element to move the stopper in a small form factor which enables a compact device.

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  • Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un dispositif d'injection automatique comprenant une aiguille d'insertion conçue pour être introduite dans un patient et un récipient de médicament qui contient un produit pharmaceutique. Le récipient de médicament comprend un bouchon. Le dispositif d'injection automatique comprend également un trajet de fluide qui relie fluidiquement le récipient de médicament à l'aiguille d'insertion. Le dispositif d'injection automatique comprend en outre un système d'entraînement conçu pour provoquer un mouvement linéaire parallèle du bouchon de manière à forcer le produit pharmaceutique à entrer dans le trajet de fluide. Le système d'entraînement comprend un élément d'entraînement et un élément mobile. Le dispositif d'injection automatique comprend en outre des composants électroniques conçus pour fournir un signal au système d'entraînement afin de déplacer le bouchon et comprend des moyens pour détecter la position du bouchon. L'élément mobile comprend un aimant externe entourant au moins en partie le récipient de médicament et un aimant interne à l'intérieur du récipient de médicament.
PCT/US2019/027136 2018-04-12 2019-04-12 Dispositif d'injection automatique comprenant un système d'entraînement magnétique WO2019200198A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15/951,425 US10967118B2 (en) 2016-02-19 2018-04-12 Automatic injection device having a magnetic drive system
US15/951,425 2018-04-12

Publications (1)

Publication Number Publication Date
WO2019200198A1 true WO2019200198A1 (fr) 2019-10-17

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022021989A1 (fr) * 2020-07-30 2022-02-03 浙江大学 Système et méthode d'administration de médicament automatique
US11317944B2 (en) 2011-03-14 2022-05-03 Unomedical A/S Inserter system with transport protection
US11458292B2 (en) 2019-05-20 2022-10-04 Unomedical A/S Rotatable infusion device and methods thereof
US11617827B2 (en) 2005-09-12 2023-04-04 Unomedical A/S Invisible needle

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Publication number Priority date Publication date Assignee Title
WO2011133724A2 (fr) * 2010-04-20 2011-10-27 Minipumps, Llc Dispositifs de pompes à médicaments à commande électrolytique
US20160367751A1 (en) * 2015-06-22 2016-12-22 Medtronic Minimed, Inc. Occlusion detection techniques for a fluid infusion device having a rotary pump mechanism and rotor position sensors
WO2017007952A1 (fr) 2015-07-07 2017-01-12 Flextronics Ap, Llc Pompe à timbre stérile
US20170239414A1 (en) * 2016-02-19 2017-08-24 Flextronics Ap, Llc Automatic injection device having a magnetic drive system
WO2018027937A1 (fr) * 2016-08-12 2018-02-15 Medtrum Technologies Inc. Système de distribution comprenant un capteur de position.

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011133724A2 (fr) * 2010-04-20 2011-10-27 Minipumps, Llc Dispositifs de pompes à médicaments à commande électrolytique
US20160367751A1 (en) * 2015-06-22 2016-12-22 Medtronic Minimed, Inc. Occlusion detection techniques for a fluid infusion device having a rotary pump mechanism and rotor position sensors
WO2017007952A1 (fr) 2015-07-07 2017-01-12 Flextronics Ap, Llc Pompe à timbre stérile
US20170239414A1 (en) * 2016-02-19 2017-08-24 Flextronics Ap, Llc Automatic injection device having a magnetic drive system
WO2018027937A1 (fr) * 2016-08-12 2018-02-15 Medtrum Technologies Inc. Système de distribution comprenant un capteur de position.

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11617827B2 (en) 2005-09-12 2023-04-04 Unomedical A/S Invisible needle
US11317944B2 (en) 2011-03-14 2022-05-03 Unomedical A/S Inserter system with transport protection
US11458292B2 (en) 2019-05-20 2022-10-04 Unomedical A/S Rotatable infusion device and methods thereof
US11944775B2 (en) 2019-05-20 2024-04-02 Unomedical A/S Rotatable infusion device and methods thereof
WO2022021989A1 (fr) * 2020-07-30 2022-02-03 浙江大学 Système et méthode d'administration de médicament automatique

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