WO2019194666A1

WO2019194666A1 - Apparatus and method for microwave therapy for treating blood cancer

Info

Publication number: WO2019194666A1
Application number: PCT/KR2019/004146
Authority: WO
Inventors: 김남영; 김은성
Original assignee: 광운대학교 산학협력단
Priority date: 2018-04-06
Filing date: 2019-04-08
Publication date: 2019-10-10

Abstract

The present invention relates to an apparatus and a method for microwave therapy for treating blood cancer. The apparatus comprises: 1) a plurality of porous anodic aluminum oxide filters (AAO filters) or a plurality of porous glass filters; 2) a nanoflowers filter; and 3) an RF absorber which emits a frequency of a specific band so as to collect cancer cells, wherein the porous anodic aluminum oxide filters (AAO filters) or porous glass filters, the nanoflowers filter, and the RF absorber are provided inside a dialyzer of a hemodialysis machine. The apparatus removes cancer cells by means of an RF frequency and circulates and supplies blood in a bloodstream direction to veins in the body of a blood cancer patient.

Description

Microwave therapy apparatus and method for blood cancer treatment

The present invention relates to a microwave treatment apparatus and method for the treatment of hematologic cancer, more specifically, in the dialysis machine of the hemodialysis apparatus for the treatment of hematological cancer of leukemia patients

I) filtering cancer cells larger than the diameter of normal blood cells circulated through blood vessels by size filtering of i) a plurality of porous anodized aluminum oxide filters (AAO filters) or a plurality of porous glass filters; If the diameter size of is equal to or smaller than the size of normal blood cells, the cancer cells adhere to each other by the nanoflower filter, and the cancer cell is removed by irradiating 450MHz RF frequency by turning on and off the RF resonator of the microwave RF generator at regular intervals. Blood cancer treatment, which collects and removes cancer cells in the RF Absorber by irradiating 13.56 MHz, 27.12 MHz, 40.68 MHz, 54.12 MHz RF frequencies by RF Absorbers provided on the upper and lower surfaces of blood tubes in the RF shielding tube in the dialysis machine A microwave treatment device and method. The RF Absorber means an RF cancer cell absorber.

According to Seoul National University Hospital, the bones of our body are involved in the regulation of calcium to maintain body shape and exercise, and the bones inside the bones are less dense than the bones, which are white blood cells, red blood cells, platelets, etc. Functions to make blood cells.

Blood is composed of blood cells (hemocytes) and plasma (plasma), and consists of blood cell components that make up about 45% of the total blood volume. Blood cells consist of white blood cells, red blood cells, and platelets.

Leukocytes are blood cells that play an essential role in the destruction of infectious agents and the body's defense against antibodies. Erythrocytes are blood cells that carry oxygen and contain pigments (hemoglobin), with the largest number of red blood cells. Platelets are blood cells that clot blood and prevent bleeding.

Plasma is a pale yellow transparent blood liquid component that accounts for 55% of the total blood volume, and most components are composed of water (91%), which includes blood coagulation factors and electrolytes essential for life support. Others include plasma proteins (7%) such as albumin and blood coagulation factors, electrolytes (Na +, Cl-, HCO ₃ , K +, etc.), glucose, amino acids, lipids, vitamins, hormones, and waste products.

Leukemia is a blood cancer of leukocytes among these blood cells. Leukemia is a type of cancer and is also called 'marrow cancer' because of problems with hematopoietic cells. Along with lymphoma, multiple myeloma, etc., it belongs to the big category of hematologic cancer. Acute myeloid leukemia, called 'blood cancer', is the appearance of leukemia cells in the bone marrow or blood.

Acute leukemia is a blood cancer in which leukocytes turn into malignant cells, multiply in the bone marrow, spread to the blood, spread throughout the body, and invade the liver, spleen, and lymph glands. Blood cancer can cause many symptoms, such as anemia, white blood cell reduction, and platelet reduction, which can interfere with blood production.

In leukemia, abnormal white blood cells (leukemia cells) multiply excessively, and the production of normal white blood cells, red blood cells, and platelets is suppressed. A decrease in normal white blood cell counts can lead to immunodeficiency, which can lead to sepsis caused by bacterial infection, a decrease in red blood cells leads to anemia symptoms (dizziness, headache, shortness of breath), and a decrease in platelets causes a tendency to bleed. In addition, overly proliferated leukemia cells themselves may cause high fever, fatigue, bone pain, diarrhea, loss of consciousness, shortness of breath, and bleeding. When leukemia patients are not treated, these symptoms put their lives at risk.

Leukemia is divided into acute and chronic depending on the degree of cell differentiation, that is, the rate of exacerbation, and is divided into myeloid and lymphoid composition according to the origin of the cell. Leukemia is classified into four types: acute myeloid leukemia, acute lymphoblastic leukemia, chronic myeloid leukemia, and chronic lymphocytic leukemia.

Leukemia is a disease in which leukocytes proliferate oncologically and pathological glaze leukocytes leak into the blood.

A disease called hematopoietic (hematopoietic) cancer, the incidence of which is low, but once onset, life is dangerous. White blood refers to white blood, which was named after the discoverer of the disease, R. Pirhoe, when the patient was autopsied in 1846.

Then, if the tissue changes are the same, but the leukocytes in the blood rarely increases is called non-leukemia. It is classified into lymphoid, myeloid, and monocytic according to the type of cells in the blood, and divided into acute and chronic in clinical course.

Although the cause is unclear, it is believed that radiation is caused by the fact that it is a frequent occurrence of a bomb victim or a radiation worker.

In acute leukemia, both lymphoid and myeloid symptoms are so rapid that high fever, stomatitis, gingivitis, and necrotic angina and bleeding tendency appear, making it easier to bleed. Lymphocytes or myeloblasts increase in the blood and red blood cells decrease, resulting in anemia. Treatment involves corticosteroids, folic acid antagonists, and purine antagonists. Transfusion is required.

Acute lymphocyte leukemia is a disease in which leukocytes of lymphocytes become malignant cells, proliferate in the bone marrow, spread to peripheral blood, and invade the liver, spleen, lymphatic system, cerebrum, cerebellum, and spinal cord. It usually affects children 3 to 5 years old and is said to be the most pediatric cancer. In general, normal blood cells are said to decrease. This is caused by exposure to radiation, carcinogens such as benzene, toluene and anticancer drugs.

Acute myeloid cell leukemia is acute leukemia of bone marrow cells, which is a malignant hematologic cancer that invades cells of bone marrow granules, and is called hematologic malignancy that proliferates in the bone marrow and metastasizes to peripheral blood or other organs.

Cause: It is not clear and it is caused by exposure to radiation, carcinogens such as benzene, toluene and anticancer drugs.

Symptoms: Symptoms such as a cold or body aches, fever, general fatigue, thrombocytopenia, bleeding, anemia, paleness, enlarged gums, large liver and pancreas, and tender masses.

Treatment: Treatment includes chemotherapy, radiation therapy, hematopoietic stem cell transplantation.

Hematopoietic stem cell transplantation is the "transplanting of mother cells that make blood," and in the center of bone there are blood-forming cells, which produce blood cell components such as red blood cells, white blood cells, and platelets (the role of preventing bleeding). However, in order to fundamentally treat diseases of hematopoietic stem cells such as leukemia, high-dose chemotherapy and systemic radiation are used to remove all cancer cells, empty the bone center completely, and then transfer the hematopoietic stem cells of healthy people. It is a treatment that restores the ability of the hair cells to live anew and the cells to be split and multiply to make blood.

In the past, it was called bone marrow transplantation because he received stem cells from another person's bone marrow (bone center), but now he can get stem cells from umbilical cord blood or peripheral blood. The term "hematopoietic stem cell transplant" rather than "transplantation" is used. Hematopoietic stem cells are stem cells that make up the red blood cells, white blood cells, and platelets that make up blood and are contained in bone marrow (bone), peripheral blood, and cord blood.

Blood cancer patients, such as leukemia, do not produce healthy blood and are difficult to sustain. Therefore, there is a method of providing healthy hematopoietic stem cells by a donor with a histocompatibility antigen type (HLA) such as a blood cancer patient to maintain life by transplanting healthy hematopoietic stem cells donated by others to produce blood that functions normally.

Chronic myeloid leukemia is the most frequent type. The symptoms gradually develop due to general boredom and loss of appetite, and the skin becomes pale and moves to anemia. The liver and spleen are enlarged and bone pain, beating pain, fundus changes, and vision loss occur. In addition, platelets are reduced, resulting in non-bleeding, gingival bleeding, subcutaneous bleeding, and cerebral hemorrhage, and fever at the end. The number of leukocytes increases tremendously, increasing from 100,000 to 300,000 (multiple of 5,000 to 9,000 per cubic millimeter of normal blood), and most of them are myeloids, which are markedly impaired. Transfusion is used in combination with various anti-leukemic drugs and corticosteroids.

Chronic lymphocytic leukemia is a symptom of which lymph nodes of the whole body are in turn, especially in the cervical and groin areas. The egg size is about the size of the fist, anemia is also present, leukocytes increase, most of which is also occupied by lymphatic glaze. Treatment is similar to myeloid, with the administration and treatment of anti-leukemia drugs.

As a related art 1, Patent Registration No. 10-05317480000 has registered a DNA chip for diagnosis of leukemia for analyzing leukemia specific gene abnormalities.

A leukemia diagnostic DNA chip for analyzing leukemia specific gene abnormalities, a method for producing an electrical DNA chip, and a leukemia diagnostic genotyping kit including an electrical DNA chip are provided. The leukemia diagnostic DNA chip consists of 18 to 25 nucleotides, and includes a gene probe for detecting leukemia specific gene abnormalities; A linker comprising 15 thymine (dTTP), 6 CH2 chains and an amine group sequentially, wherein the 5 'end of the electric gene probe is linked to the thymine site; And, aldehyde is bonded to the surface, and the amine group of the electric linker includes a solid connected through the reaction of the aldehyde group and the surface (Schiff's base) of the surface. Using the genotyping kit, the genotype of leukemia can be distinguished quickly and accurately, so it can be widely used for early diagnosis of leukemia.

As a related art 2, Patent Registration No. 10-10811140000 registers "a leukemia diagnostic apparatus using DNA information and its operation method".

Disclosed are a leukemia diagnostic apparatus using DNA information and a method of operating the same. Leukemia diagnostic device using the DNA information test value storage unit for storing the test information generated by digitizing the DNA information of the patient; A reference storage unit for storing a plurality of reference information formed of DNA information having characteristics of leukemia; A mask storage unit for storing a plurality of masks including information on portions of the test information and the reference information to be compared with each other; A comparison unit comparing the test information and the portion corresponding to the mask in the reference information to check whether they match with each other; An accumulating unit for generating matching amount information which is the sum of the portions which the comparing unit has confirmed to match; And a determination unit for determining reference information with the largest amount of matching information and displaying a diagnosis result corresponding to the reference information with the highest amount of matching information.

As a related art 3, Patent Publication No. 10-2015-0041130 discloses "leukemia classification using CPD data". Embodiments encompass automated systems and methods for predicting acute leukemia subtypes in individuals diagnosed with acute leukemia based on biological samples obtained from the blood of the individual. Exemplary techniques involve correlating aspects of direct current (DC) impedance, high frequency (RF) conductivity, and / or photometric data obtained from a biological sample with an acute leukemia subtype of an individual.

An automated system for predicting acute leukemia subtypes in an individual based on a biological sample obtained from the blood of an individual diagnosed with acute leukemia,

(a) an optical element having a cell interrogation zone; (b) a flow path configured to deliver a hydrodynamically focused stream of the biological sample towards the cellular test zone; (c) an electrode assembly configured to measure direct current (DC) impedance and high frequency (RF) conductivity of cells of the biological sample individually passing through the cell test zone; (d) a light source oriented to direct a light beam along a beam axis to irradiate the cells of the biological sample individually passing through the cell test zone; And (e) a light detection assembly optically coupled to the cell test zone for measuring light scattered by and transmitted by the lighted cells of the biological sample,

The light detection assembly comprises: (i) first propagated light from the irradiated cells within a first range of angles with respect to the light beam axis; (ii) second propagated light from the irradiated cells within a second range of angles with respect to the light beam axis, the second range being different from the first range; And (iii) measure axial light propagated from the irradiated cells along the beam axis;

(f) the system includes a subset of DC impedance, RF conductivity, the first propagated light, the second propagated light, and the axial light measurements from the cells of the biological sample in the acute leukemia of the individual. Configured to correlate with subtypes.

A method for predicting an acute leukemia subtype of an individual based on a biological sample obtained from the individual's blood, the method comprising: (a) delivering a hydrodynamically focused stream of the biological sample towards a cell test zone of an optical element; (b) measuring, with an electrode assembly, current (DC) impedance and high frequency (RF) conductivity of cells of the biological sample individually passing through the cell test zone; (c) irradiating light with cells of the biological sample individually through the cell test zone with an axis of light beam; (d) measuring, with the light detection assembly, first propagated light from the irradiated cells within a first range of angles with respect to the beam axis; (e) with the light detection assembly, second propagated light from the irradiated cells within a second range of angles relative to the beam axis, the second range being different from the first range Measuring; (f) measuring, with the light detection assembly, axial light propagated from the irradiated cells along the beam axis; And (g) a subset of DC impedance, RF conductivity, the first propagated light, the second propagated light, and the axial light measurements from the cells of the biological sample, the predicted acute leukemia of the individual. Correlating with subtypes.

According to the National Cancer Center, hematopoietic stem cell transplantation is a treatment that removes cancer cells and hematopoietic stem cells and transplants new hematopoietic stem cells with powerful chemotherapy or radiation to patients with hematologic malignancies such as leukemia, myelodysplastic syndrome, malignant lymphoma and multiple myeloma. Use Anticancer drugs have many side effects, and dangerous side effects are the destruction of myeloid cells, causing hypocythemia. However, over time, white blood cells are palpable, but platelets may not survive.

However, although conventional chemotherapy or radiotherapy has been performed for the treatment of leukemia, microwave treatment devices that are less harmful to the human body than chemotherapy and radiation therapy have not been developed for the treatment of leukemia. Did.

Prior art literature

Patent Literature

(Patent Document 1) Patent Registration No. 10-05317480000 (Registration date November 22, 2005), "DNA chip for leukemia diagnosis", BMS Co., Ltd.

(Patent Document 2) Patent Registration No. 10-10811140000 (Registration date November 01, 2011), "Leukemia diagnosis device using DNA information and its operation method", Inha University Industry-Academic Cooperation Group

(Patent Document 3) Patent Publication No. 10-2015-0041130 (Registration date April 15, 2015), "Leukemia Classification Using CPD Data", Beckman Culter, Inc.

SUMMARY OF THE INVENTION An object of the present invention for solving the above problems is that i) a plurality of porous anodized aluminum oxide filters (AAO filters) or a plurality of porous glass filters provided inside a dialysis machine of a hemodialysis apparatus for treating hematological cancers of leukemia patients. Filters cancer cells larger than the diameter of normal blood cells circulated through blood vessels by size filtering, and ii) allows cancer cells to stick to them by nanoflowers filter if the diameter of the cancer cells is equal to or smaller than the size of normal blood cells. The cancer cell is removed by irradiating 450MHz RF frequency by turning on / off the microwave resonator of the microwave RF generator at regular intervals, and iii) 13.56 by the RF Absorber provided on the upper and lower surfaces of the blood tube in the RF shielding tube in the hemodialysis machine. By collecting the cancer cells in the RF Absorber by irradiating the MHz, 27.12 MHz, 40.68 MHz, 54.12 MHz RF frequencies, Provided is a microwave treatment device for treating blood cancer.

Another object of the present invention to provide a microwave treatment method for the treatment of blood cancer.

In order to achieve the object of the present invention, the microwave treatment apparatus for treating hematological cancer according to the fourth embodiment is provided in a dialyzer of a hemodialysis apparatus connected to blood vessels, and a plurality of porous anodized aluminum oxides. An AAO filter or a plurality of porous glass filters; A nanoflower filter provided at a rear end of the plurality of porous anodized aluminum oxide filters or the plurality of porous glass filters and connected to blood vessels of blood vessels of cancer patients; And an RF absorber provided at a rear end of the nanoflower filter and collecting the cancer cells with the RF absorber by irradiating a frequency of a specific band.

Cancer cells are removed by the RF frequency and blood, including normal blood cells that have passed through the nanoflower filter, is circulated and supplied to blood vessels connected to veins of the human body of the blood cancer patient in the blood flow direction.

The microwave treatment device for blood cancer treatment further includes a microwave RF generator for attaching cancer cells to the nanoflower filter, and removing the cancer cells by irradiating the RF frequency by turning on / off the RF resonator of the RF generator at regular intervals.

The plurality of porous anodized aluminum oxide filters (AAO filters) pass through normal blood cells having a smaller pore diameter than cancer cells by using a hemodialysis method, and abnormal blood cells including cancer cells having a larger pore diameter than the normal blood cells. When the filter is filtered, the diameter of the cancer cells is the same as or smaller than the size of the normal blood cells, the RF resonator of the microwave RF generator at regular intervals by irradiating the RF frequency to remove the cancer cells.

The plurality of porous anodized aluminum oxide filters (AAO filter) has a porous anodized aluminum oxide filters having a plurality of pores smaller than the diameter of the cancer cells and the pore diameter is smaller, less than the diameter of the cancer cells and the pore diameter Three other porous anodized aluminum oxide filters are used.

The three porous anodized aluminum oxide filters (AAO filters) include a first porous anodized aluminum oxide filter having a first pore diameter, and a second porous anodized aluminum oxide filter having a second pore diameter smaller than the first pore diameter. And a third porous anodized aluminum oxide filter having a third pore diameter smaller than the second pore diameter, wherein the first pore diameter, the second pore diameter, and the third pore diameter are 60, 30, and 10, respectively. It has a hole size of μm.

After the hemodialysis of the plurality of porous anodized aluminum filters, a plurality of porous anodized aluminum oxide filters are replaced from the dialysis machine and are harmless to the human body.

The plurality of porous glass filters have porous glass filters having a plurality of pores that are smaller than the diameter of the cancer cells and the pores become smaller and smaller, and use three glass filters that are smaller than the diameter of the cancer cells and have different pore diameters.

The three porous glass filters may include a first porous glass filter having a first pore diameter, a second porous glass filter having a second pore diameter smaller than the first pore diameter, and a third pore diameter smaller than the second pore diameter. And a third porous glass filter having the first pore diameter, the second pore diameter, and the third pore diameter, each having a pore diameter of 60, 30, and 10 μm.

After the hemodialysis of the plurality of porous glass filters, it is replaced with a new plurality of porous glass filters which are separated from the dialysis machine and are harmless to the human body.

If the size of the cancer cells is the same or smaller than the size of normal blood cells, the cancer cells stick to the nanoflower filter provided in the dialysis machine of the hemodialysis device from the blood vessel connected to the artery of the blood vessel of the cancer patient,

Cancer cells are removed by irradiating the 450MHz RF frequency by turning the 1.8W microwave RF resonator on and off at regular intervals.

The nanoflower filter is planted with gold (Au) to improve the reaction rate, and adheres abnormal cells (abnormal cells), that is, cancer cells, and nanoparticles that are separated from the dialysis machine and adhered to cancer cells after hemodialysis of cancer patients. The flower filter is replaced with a new nanoflower filter.

The RF Absorber is provided on the upper and lower surfaces of the blood tube in the RF shielding tube in the hemodialysis machine, and collects cancer cells in the RF Absorber by irradiating 13.56 MHz, 27.12 MHz, 40.68 MHz, 54.12 MHz RF frequencies by the RF Absorber. Remove and remove the RF Absorber after hemodialysis.

The RF Absorber uses at least one RF frequency within the 13.56 MHz to 54.12 MHz frequency.

It further comprises an RF shield room (RF shield room, RF shield box) for shielding the blood vessel 10 in the dialyzer of the hemodialysis apparatus, the RF shielding tube uses a plastic, aluminum, ceramic material, rubber material To shield the frequency outside the hemodialyzer using an RF shielding material, the RF shielding tube is manufactured in the form of a quadrangular box, cylindrical, 5,6,7, octahedra polygons in the dialysis machine of the hemodialysis device,

The RF shield cuts the RF frequency of the MHz to GHz band,

The RF shielding material uses silver (Ag) as a screening material and an Aaronia shielding material that blocks 100 MHz to 10 GHz band RF frequency, or a 1 MHz to 50 GHz band RF frequency that uses stainless steel as the screening material. Remove the RF Absorber after hemodialysis, using Lonia X-Steel.

In order to achieve another object of the present invention, the microwave treatment method for treating hematological cancer according to the fourth embodiment is (a) blood vessels of a leukemia patient during circulation of blood in the blood flow direction when the blood pump is operated by hemodialysis Blood is supplied from blood vessels connected to the arteries of the blood vessel and includes a plurality of porous anodized aluminum oxide filters (AAO filters) or a plurality of porous glass filters inside a dialysiszer of the hemodialysis apparatus, and the diameter of the cancer cells is increased by the filter. Passing these small normal blood cells and filtering and filtering abnormal blood cells including cancer cells larger in diameter than the normal blood cells; (b) a plurality of AAO filters or a plurality of porous glass filters provided inside a dialyzer of the hemodialysis apparatus, and a nanoflowers filter next to each other, wherein the cancer cells are attached to each other by the nanoflower filter; ; (c) removing cancer cells by irradiating an RF frequency by turning on / off the RF resonator of the microwave RF generator at regular intervals; And (d) irradiating a frequency of a specific band by an RF absorber provided at the rear of the nanoflower filter to collect cancer cells with the RF absorber and removing the RF absorber.

The blood, including the normal blood cells from which the cancer cells have been removed, is circulated and supplied to the blood vessel connected to the vein of the human body of the cancer patient in the blood flow direction.

The method is characterized in that if the size of a cancer cell is equal to or smaller than that of a normal blood cell, the 1.8 W microwave RF generator may be used at regular intervals in a filter provided in the dialysis apparatus of the hemodialysis apparatus from a blood vessel connected to an artery of a blood vessel of a cancer patient. And turning on / off the RF resonator and irradiating a 450 MHz RF frequency to remove cancer cells.

The RF Absorber is provided on the upper and lower surfaces of the blood tube in the RF shielding tube in the hemodialysis machine, and collects cancer cells in the RF Absorber by irradiating 13.56 MHz, 27.12 MHz, 40.68 MHz, 54.12 MHz RF frequencies by the RF Absorber. And removing the RF absorber after hemodialysis.

The method further includes removing the plurality of porous anodized aluminum oxide filters (AAO filters) or the plurality of porous glass filters, the nanoflower filters to which the cancer cells are attached, and the RF absorber in which the cancer cells are collected after hemodialysis. .

Microwave treatment apparatus and method for blood cancer treatment of the present invention is i) a plurality of porous anodized aluminum oxide filter (AAO filter) provided in the dialysis machine of the hemodialysis device for blood cancer therapy (leukemia) of leukemia patients Or filtering cancer cells larger than the diameter of normal blood cells circulated through blood vessels by size filtering of a plurality of porous glass filters, ii) nanoflowers if the diameter of the cancer cells is equal to or smaller than the size of normal blood cells. ) Cancer cells adhere to each other by a filter, and at regular intervals, the RF resonator of the microwave RF generator is turned on and off to irradiate the 450MHz RF frequency to remove the cancer cells. The RF Absorber is used to irradiate 13.56 MHz, 27.12 MHz, 40.68 MHz, and 54.12 MHz RF frequencies to the RF Absorber. It gathered to hear the effect of removing the RF Absorber cancer gathered.

Hematodialysis is performed by supplying the abnormal blood cells with filtered blood circulated to blood vessels connected to the veins of the human body of the leukemia patient in the blood flow direction (artery-> vein), thereby providing cancer cells after hemodialysis of the leukemia patient. Remove them.

Microwave treatment device that is less harmful to human body for the treatment of leukemia in this study is less harm to human body than conventional chemotherapy or radiotherapy and removes cancer cells to remove blood cancer such as leukemia. It can be applied to treatment of cancer.

FIG. 1 is a diagram showing cells of blood having different pore sizes of cancer cells having a diameter larger than normal blood cells.

2 is a view showing a microwave treatment apparatus by a plurality of porous anodized aluminum oxide filter (Example 1) or a plurality of porous glass filters (Example 2) for treating leukemia according to an embodiment of the present invention.

3 is a diagram illustrating a hemodialysis method using three porous anodized aluminum oxide filters (AAO filters) in a dialysis machine for treating leukemia according to the present invention.

4 is a view showing a structure in which the pore size of a porous anodized aluminum oxide filter (AAO filter) that is chemically safe and harmless to a human body can be controlled based on abnormal blood cells (cancer cells).

5 is a diagram illustrating a hemodialysis apparatus having a blood tube, a blood pump, and a dialysis machine.

6 to 8 is a view showing a microwave treatment method by nano-flowers (nanoflowers) for cancer treatment to remove cancer cells using the RF frequency according to the third embodiment of the present invention.

9 is a diagram showing the removal of cancer cells using a one-step AAO filter and a two-step nanoflowers filter.

9 is a diagram showing the removal of cancer cells by irradiating 450 MHz RF frequency by turning ON / OFF the 450 MHz RF frequency and the 1.8 W microwave RF resonator in a nanoflower filter of the dialysis machine of the hemodialysis apparatus.

FIG. 10 is a diagram illustrating the removal of cancer cells using a one-step AAO filter and a two-step nanoflower filter in a dialyzer.

11 and 12 are provided with a plurality of porous AAO filter or porous glass filter (step 1) / nanoflowers (step 2) / RF Absorber (step 3) according to a fourth embodiment of the present invention, and is provided at regular intervals by an RF generator. It is shown that the cancer cells are removed by irradiating the 450MHz RF frequency by turning on / off the RF resonator of the microwave RF generator.

Figure 13 shows the process of collecting and removing cancer cells in the RF Absorber by irradiating RF frequencies 13.56 MHz, 27.12 MHz, 40.68 MHz, 54.12 MHz by RF Absorber provided on the upper and lower surfaces of the blood vessel in the RF shielding tube in the hemodialysis machine Drawing.

Figure 14 shows the results of experiments on the migration of skin cancer WM and G361 cells prior to testing the blood cancer cells in the solution on October 24, 2018, the control (if not using RF frequency) and Treated (RF frequency) Is used for 20 hours).

FIG. 15 shows the results of measuring the relative mRNA mobility of the qPC-Cell gene biomarker in skin cancer WM and G361 cells in solution on February 12, 2019, using control (when not using RF frequency) and Treated ( Experimental data comparing RF frequency when used for 20 hours).

Hereinafter, with reference to the accompanying drawings, preferred embodiments of the present invention will be described in detail the configuration and operation of the invention.

FIG. 1 is a diagram showing cells of blood having different pore sizes of cancer cells having a diameter larger than normal blood cells. The bones of our body maintain the body shape and are involved in the regulation of calcium. The bone marrow tissue, which is less dense than the bones, creates blood cells such as white blood cells, red blood cells, and platelets.

Leukemia is a blood cancer (myeloid cancer) that occurs in white blood cells among these blood cells, and abnormal leukocytes (leukemia cells) excessively proliferate and normal leukocytes, red blood cells, and platelets are inhibited from being produced. A decrease in normal white blood cell counts can lead to immunodeficiency, which can lead to sepsis caused by bacterial infection, a decrease in red blood cells leads to anemia symptoms (dizziness, headache, shortness of breath), and a decrease in platelets causes a tendency to bleed.

When leukemia develops, white blood cells become larger and cancer cells become larger.

Cancer cells larger than the diameter of normal blood cells supplied through the blood tube into the bloodstream using a hemodialysis method may be used to remove multiple AAO filters (Example 1) or multiple glass filters (Example 1) in a dialysis machine in a hemodialysis apparatus. Size 2 is filtered using Example 2 to remove cancer cells.

The present invention relates to a microwave treatment apparatus and method for the treatment of blood cancer, and more particularly, i) a plurality of porous anodizations provided in the dialysis machine of the hemodialysis apparatus for blood cancer therapy of leukemia patients. Filter cancer cells larger than the diameter of normal blood cells circulating through the blood tube by size filtering of an aluminum oxide filter (AAO filter) or a plurality of porous glass filters, ii) diameter of cancer cells equal to the size of normal blood cells When small or small, nanoflowers filter causes cancer cells to stick and removes cancer cells by irradiating 450MHz RF frequency by turning the RF resonator of the microwave RF generator on / off at regular intervals, and iii) in the RF shielding tube in the hemodialysis machine. 13.56 MHz, 27.12 MHz, 40.68 MHz, 54.12 MHz RF Note by RF Absorber on upper and lower surface of blood tube By examining the number of cancer cells to assemble the RF Absorber to remove the tumor RF Absorber gathered.

Example 1 Using AAO Filters

Microwave treatment device using porous anodized aluminum oxide filter (AAO filter) for the treatment of leukemia

Blood is supplied from a blood vessel (10) connected to an artery of a blood vessel of a leukemia patient, and many (three) porous anodizations are smaller than the diameters of cancer cells provided in the dialysis machine of the blood pump and the hemodialysis apparatus, and the pore diameter becomes smaller. AAO filter, Anodic Aluminum Oxide filter (30, 31, 32),

The plurality of porous aluminum oxide oxide filters (AAO filter) (30, 31, 32) or the porous glass filter is provided inside the dialyzer (dialyzer) of the hemodialysis apparatus, hematodialysis method using a hemodialysis (Hematodialysis) method Passing normal blood cells 17 of small size with a small pore diameter, and filtering and filtering abnormal blood cells 23 including cancer cells having a larger pore diameter than the normal blood cells; If the diameter of cancer cells is the same or smaller than the size of normal blood cells, the cancer cells are removed by irradiation of 450MHz RF frequency by turning the RF resonator of the 1.8W microwave RF generator on / off at regular intervals.

Blood vessels (10) connected to the veins of the leukemia patient in the blood flow direction (artery-> venous) through the blood vessels (10) through which blood vessels (23) are filtered and abnormal blood cells (17) have passed. Circulate to supply.

The plurality of porous anodized aluminum oxide filters (AAO filters) 30, 31, and 32 have porous anodized aluminum oxide filters having a plurality of pores that are smaller than the diameter of the cancer cells and the pore diameter becomes smaller. Three porous anodized aluminum oxide filters smaller than the diameter of the pores and with different pore diameters are used.

The three porous anodized aluminum oxide (AAO) filters 30, 31, and 32 may include a first porous anodized aluminum oxide filter 30 having a first pore diameter, and a material smaller than the first pore diameter. A second porous anodized aluminum oxide filter 31 having a second pore diameter, and a third porous anodized aluminum oxide filter 32 having a third pore diameter smaller than the second pore diameter, wherein the first pore diameter The second pore diameter and the third pore diameter are smaller diameters, and have a pore diameter of 60, 30, and 10 μm, respectively.

In addition, the microwave treatment method by the porous anodized aluminum oxide filtering for leukemia treatment of the present invention, blood cancer treatment such as leukemia including a plurality of porous anodized aluminum oxide filter (AAO filter) inside the dialyzer of the hemodialysis apparatus In the microwave treatment method for:

(a) a large number of porous anodizations inside the dialysiszer of the hemodialysis apparatus in which blood is supplied from blood vessels 10 connected to the arteries of the blood vessels of the leukemia patient during circulation of blood in the blood flow direction at the time of blood pump operation An aluminum oxide filter (AAO filter, Anodic Aluminum Oxide filter) (30, 31, 32) is provided, and the AAO filter (30, 31, 32) is passed through the normal blood cells 17 of smaller diameter than cancer cells When the abnormal blood cells including cancer cells 23 having a diameter larger than those of the normal blood cells 17 are filtered, the microwave RF is periodically filtered when the diameter of the cancer cells is equal to or smaller than the size of the normal blood cells. Removing cancer cells by irradiating an RF frequency by turning on / off an RF resonator of a generator; And

(b) The abnormal blood cells 23 are filtered and the blood having passed through the normal blood cells 17 is circulated through the blood vessel 10 to the blood vessel connected to the vein of the human body of the leukemia patient in the blood flow direction. It includes a step.

The three porous anodized aluminum oxide (AAO) filters (30, 31, 32) are

A first porous anodized aluminum oxide filter 30 having a first pore diameter, a second porous anodized aluminum oxide filter 31 having a second pore diameter smaller than the first pore diameter, and smaller than the second pore diameter. And a third porous anodized aluminum oxide filter 32 having a third pore diameter, wherein the first pore diameter, the second pore diameter, and the third pore diameter are smaller and smaller, respectively. It has a hole size of μm.

If the size of the cancer cells is the same as or smaller than the size of normal blood cells, the RF resonator of the 1.8 W microwave RF generator is performed at regular intervals in a filter provided in the dialysis apparatus of the hemodialysis apparatus from blood vessels connected to the arteries of blood vessels of the cancer patient. Turn ON / OFF to remove the cancer cells by irradiation of 450MHz RF frequency.

The method further comprises the steps of: (c) replacing the plurality of porous anodized aluminum oxide filters or the plurality of porous glass filters with a new plurality of porous anodized aluminum oxide filters that are spaced from the dialyzer and harmless to the human body after hemodialysis. Include.

After the hemodialysis of the plurality of porous anodized aluminum oxide filters or the plurality of porous glass filters, the plurality of porous anodized aluminum oxide filters or a new plurality of porous glass filters spaced from the dialysis machine and harmless to the human body are replaced.

Example 2 describes the case of using a plurality of glass filters instead of using a plurality of AAO filters (Example 1) in a dialysis machine of a hemodialysis apparatus having a blood tube and a blood pump.

Example 2 Microwave treatment apparatus for blood cancer treatment by a plurality of porous glass filters in the dialyzer

Microwave treatment apparatus for blood cancer treatment, such as leukemia according to the second embodiment

A plurality of (3) porous glass filters inside the dialyzer of the hemodialysis device supplied with blood from blood vessels connected to the arteries of the blood vessels of the leukemia patient,

The plurality of porous glass filters are provided inside a dialyzer of the hemodialysis apparatus, and pass a hemodialysis method to pass normal blood cells having a smaller pore diameter than cancer cells, and have a larger pore diameter than the normal blood cells. Abnormal blood cells, including cancer cells, are filtered out; If the diameter of cancer cells is the same or smaller than the size of normal blood cells, the cancer cells are removed by irradiation of 450MHz RF frequency by turning the RF resonator of the 1.8W microwave RF generator on / off at regular intervals.

The abnormal blood cells are filtered and the blood passed through the normal blood cells is circulated and supplied to the blood vessel connected to the vein of the human body of the leukemia patient in the blood flow direction.

The plurality of porous glass filters 30, 31, and 32 have porous glass filters having a plurality of pores that are smaller than the diameters of cancer cells and the pore diameters become smaller, and are smaller than the diameters of the cancer cells and have different pore diameters. A large porous glass filter is used.

The three porous glass filters 30, 31, and 32 may include a first porous glass filter 30 having a first pore diameter, and a second porous glass filter 31 having a second pore diameter smaller than the first pore diameter. And a third porous glass filter 32 having a third pore diameter smaller than the second pore diameter, wherein the first pore diameter, the second pore diameter, and the third pore diameter are smaller and smaller diameters. Each has a pore size of 60, 30, 10 μm.

After the hemodialysis of the plurality of porous glass filters 30,31,32, it is replaced with a new plurality of porous glass filters which are separated from the dialysis machine and are harmless to the human body.

Microwave treatment device that is less harmful to human body for the treatment of blood cancer such as leukemia in this study is less harmful to human body than conventional chemotherapy or radiotherapy and can be applied to leukemia treatment and cancer treatment. A medical clinical trial is scheduled.

5 is a diagram illustrating a hemodialysis apparatus having a blood tube, a blood pump, and a dialysis machine. In the embodiment, three porous anodized aluminum oxide filters (AAO filters) having a pore size of 60, 30 and 10 [mu] m, respectively, are provided in the dialyzer.

For reference, the patient's blood is passed through a dialysis machine (artificial kidney) to filter the blood, and then put the blood back into the patient's blood vessels is a method of dialysis therapy used in the terminal renal changer. A dialysis membrane is placed in a solution that is designed to remove nitrogen-containing waste from the blood of the patient, resulting in too much water and protein metabolism, and to improve acid and base equilibrium and electrolyte concentration in the plasma. By circulating a part of the blood to act as a major renal function, the device for performing this hemodialysis is called a dialysis machine (artificial kidney). Kidneys (red kidneys) exist one by one on the left and right of the body, and filter out waste products in the blood and discharge them into the urine to control the electrolyte concentration in the blood or regulate blood pressure.

Hematodialysis requires an arterial site that draws arterial blood from the patient, connects it to the artificial kidney circuit, and returns the dialysis blood back to the patient to create a pathway for dialysis treatment in the blood vessel. The blood access is called a shunt. The blood access method is a shunt method using a scrubber shunt in which a plastic cannula is inserted into the sinus and vein. Whenever dialysis of the anastomosis is enlarged, there are three methods of puncturing the shunt method and using a transplanted blood vessel. In particular, in the case of my shunt method, the arterial and venous blood vessels are connected through surgery to make the blood vessels thicker to make dialysis, and the thick blood vessels are called arteriovenous fistula. If the arteriovenous fistula is thickened by surgery, dialysis treatment is started after inserting an injection needle and connecting a dialysis machine. There are three types of catapults: coil type, flat plate type and hollow fiber type, and hollow fiber type is most used. And heparin is used to prevent blood from clotting in the catapult. Hemodialysis is usually performed three times a week, with one dialysis time being three to five hours.

Example 3 Microwave Therapy Apparatus and Method by Nanoflowers

6 to 8 are views showing a microwave treatment apparatus and method by the nano-flowers (nanoflowers) for cancer treatment to remove cancer cells using the RF frequency according to the third embodiment of the present invention.

6 and 7, the microwave treatment device by the nanoflowers (nanoflowers) for cancer treatment of the present invention,

If the size of cancer cells 23 is equal to or smaller than the size of normal blood cells 17 and size filtering is not possible, in a hemodialysis apparatus having a blood tube, a blood pump, and a dialysis machine:

At the time of circulating blood in the blood flow direction by the hemodialysis, blood is supplied from the blood vessel 10 connected to the artery of the blood vessel of the cancer patient, and the nanoflower filter (in the dialyzer of the hemodialysis apparatus) 37),

The nanoflower filter 37 adheres to cancer cells,

Periodically, 450 MHz RF frequency and 1.8W microwave RF resonator are turned on and off to remove cancer cells using 450 MHz RF frequency, and blood 17 including normal blood cells from which cancer cells have been removed by 450 MHz RF frequency is flowed in the blood flow direction. By circulating and supplying blood vessels connected to the veins of the human body of the cancer patient (artery-> vein), the cancer cells are removed by the nanoflowers filter 37 and the RF frequency after hemodialysis of the cancer patient.

Referring to FIG. 8, in the dialysis machine, the microwave treatment device for treating hematological cancer by the nanoflower filter 37 is supplied with blood from a blood vessel connected to an artery of a blood vessel of a cancer patient, and is inside a dialyzer of the hemodialysis device. Includes a nanoflowers filter (37) in the nanoflower filter, and clings the cancer cells in the nanoflower filter, to remove the cancer cells by irradiating the RF frequency by turning on / off the RF resonator of the microwave RF generator at regular intervals, The cancer cells are removed by the RF frequency, and blood, including normal blood cells that have passed through the nanoflower filter, is circulated and supplied to the blood vessel connected to the veins of the cancer patient in the blood flow direction (artery-> vein).

The device, when the size of the cancer cells is equal to or smaller than the size of normal blood cells, when blood is supplied from blood vessels connected to the arteries of the blood vessels of the cancer patient nanoflowers filter provided in the dialysis machine of the hemodialysis device In step 37, the RF resonator of the 1.8W microwave RF generator is turned on and off to irradiate the 450MHz RF frequency to remove cancer cells.

The microwave RF frequency bursts or dies of abnormal cells with microwave dynamic therapy (MDT) and microwave thermal therapy (MTT).

Microwave dynamic therapy (MDT) removes cancer cells by irradiating 450MHz RF frequency using RF resonator of 1.8W microwave RF generator at regular time intervals.

In addition, according to the microwave thermal therapy (MTT), cancer cells can kill cancer cells by 41 ~ 47 ℃ heat, for example, cancer cells can kill cancer cells at 42.3 ℃ by heat above 41 ℃, 48 At ° C, normal blood cells survive.

The nanoflower filter is planted with gold (Au) to improve the reaction rate, and abnormal cells, that is, cancer cells, adhere to each other.

Nanoflowers stick to dead cancer cells that are irradiated at RF frequencies.

For reference, nanoflower in chemistry refers to a compound of a specific element that resembles a flower when viewed under a microscope, or in some cases forms a tree called nanobouquets or nanotrees. The structure is nanometer long and thick and can only be observed by electron microscopy (SEM, TEM).

In order to improve the reaction rate, the nanoflower filter 37 is planted with gold (Au), and materials used to adhere abnormal cells, that is, cancer cells, and protein-inorganic hybrid nanoflowers are used. For example, nano particles made by coating proteins on inorganic materials such as Mn, Fe, and Se that are not harmful to human blood are used.

There are many types of receptors, proteins, lipids, and polysaccharides in the membranes of cancer cells, and there are many kinds of substances that have affinity for them. This is also harmless to possess in the human body. Nano flower filter 37 is planted with gold (Au) to improve the reaction rate. Fe and Se nanoflowers have experience, and Mn nanoflowers will be tried.

Nanoflowers show a flower-like structure and are a newly developed group of nanoparticles that attract a lot of attention due to their high stability and high efficiency. Nanoflower applications can be used as biosensors to quickly and accurately detect conditions such as diabetes, Parkinson's disease, Alzheimer's disease, and food infections. Recent studies have observed three-dimensional nanofilters for surface sensitivity enhancement using Raman spectroscopy. Nano flower system has high surface volume ratio and high petal adsorption efficiency.

The device, after hemodialysis of the cancer patient, the nanoflower filter, which is spaced apart from the dialysis machine and clings to the cancer cells, is replaced with a new nanoflower filter.

Microwave treatment method according to the cancer treatment nanoflower equipped with nanoflowers in the dialysis machine of the hemodialysis apparatus of the present invention (a) when blood circulation in the blood flow direction during operation of the blood pump, blood vessels of cancer patients A nanoflowers filter is included in the dialyzer of the hemodialysis apparatus from a blood tube connected to an artery of the cancer cell by irradiating an RF frequency by turning on / off a microwave RF resonator at regular intervals in the nanoflower filter. Removing; And (b) circulating and supplying blood including normal blood cells which have been removed by the RF frequency and passed through the nanoflower filter to blood vessels connected to veins of the human body of the cancer patient in a blood flow direction. .

The method is characterized in that if the size of the cancer cells is equal to or smaller than the size of normal blood cells, 1.8 cycles of the nanoflowers filter provided in the dialysis machine of the hemodialysis apparatus from blood vessels connected to the arteries of blood vessels of cancer patients. The W microwave RF resonator is turned on and off to irradiate the 450 MHz RF frequency to remove cancer cells.

The method further comprises the step of (c) after the hemodialysis of the cancer patient, the nanoflower filter to which the cancer cells adhere from the dialysis machine is replaced with a new nanoflower filter.

FIG. 10 is a diagram showing the removal of cancer cells using a one-step AAO filter and a two-step nanoflower filter in a dialyzer.

In addition, the microwave treatment device for the treatment of blood cancer of the present invention

A plurality of porous anodized aluminum oxide filters (AAO filters) or a plurality of porous glass filters, which are provided inside a dialyzer of a hemodialysis apparatus connected to blood vessels to which blood is supplied; And

Nanoflowers provided at the rear end of the plurality of porous anodized aluminum oxide filters (AAO filters) or the plurality of porous glass filters, and adhere to cancer cells when blood is supplied from blood vessels connected to arteries of blood vessels of cancer patients. ) Filter,

The microwave RF generator is turned on / off at regular intervals and irradiated with RF frequency to remove cancer cells.

Cancer cells are removed by the RF frequency and blood, including normal blood cells that have passed through the nanoflower, is circulated and supplied to blood vessels connected to the veins of the human body of the blood cancer patient in the blood flow direction.

The plurality of porous anodized aluminum oxide filters (AAO filters) pass through normal blood cells 17 having a smaller pore diameter than cancer cells using a hemodialysis method, and have larger pore diameters than the normal blood cells 17. The abnormal blood cells including the cancer cells 23 are filtered and filtered. If the diameter of the cancer cells is equal to or smaller than the size of the normal blood cells, the cancer cells 23-1 are periodically regenerated by the RF resonator of the microwave RF generator. Turn on / off the radio frequency to remove the cancer cells.

The microwave cancer treatment device for blood cancer treatment includes the nanoflower filter provided in the dialysis machine of the hemodialysis apparatus from a blood tube connected to an artery of a blood vessel of a cancer patient when the size of cancer cells is the same as or smaller than that of normal blood cells. Cling to cancer cells,

The nanoflower filter 37 is planted with gold (Au) to improve the reaction rate, and adheres abnormal cells, that is, cancer cells, and is separated from the dialysis machine after hemodialysis of cancer patients, The stuck nanoflower filter is replaced with a new nanoflower filter.

Example 4

-Many porous AAO filters or porous glass filters / nanoflowers / RF Absorber

Microwave treatment apparatus for blood cancer treatment according to a fourth embodiment of the present invention, is provided in the dialyzer (dialyzer) of the hemodialysis apparatus connected to the blood tube, a plurality of porous anodized aluminum oxide filter (AAO filter) or A plurality of porous glass filters 30, 31, 32; It is provided at the rear end of the plurality of porous anodized aluminum oxide filters (AAO filter) or the plurality of porous glass filters 30, 31, 32, and nanoflowers filter from blood vessels connected to arteries of blood vessels of cancer patients. (37); And an RF absorber (39) provided at a rear end of the nanoflower filter and collecting the cancer cells with the RF absorber by irradiating a frequency of a specific band.

The blood is removed by the RF frequency and the blood including normal blood cells passing through the filters (30, 31, 32, 37) is connected to the veins of the blood cancer patient's human body in the direction of blood flow (artery-> vein) It is circulated to the pipe 10 and supplied.

The plurality of porous anodized aluminum oxide filters (AAO filters) 30, 31, and 32 pass through normal blood cells having a smaller pore diameter than cancer cells using a hemodialysis method, and have larger pore diameters than the normal blood cells. Abnormal blood cells, including cancer cells, are filtered and filtered. If the diameter of the cancer cells is equal to or smaller than the size of normal blood cells, the cancer cells are removed by irradiating the RF frequency by turning on / off the RF resonator of the microwave RF generator at regular intervals. do.

The plurality of porous anodized aluminum oxide filters (AAO filters) 30, 31, and 32 are porous anodized aluminum oxide filters (AAO filters) having a plurality of pores that are smaller than the diameters of cancer cells and whose pore diameters become smaller. It is equipped with three porous anodized aluminum oxide filters smaller than the diameter of cancer cells and different pore diameters.

The three porous anodized aluminum oxide filters (AAO filters) include a first porous anodized aluminum oxide filter 30 having a first pore diameter, and a second porous anodized oxide having a second pore diameter smaller than the first pore diameter. An aluminum oxide filter 31, and a third porous anodized aluminum oxide filter 32 having a third pore diameter smaller than the second pore diameter,

The first pore diameter, the second pore diameter, and the third pore diameter have hole sizes of 60, 30, and 10 μm, respectively.

After the hemodialysis of the plurality of porous anodized aluminum oxide filters 30, 31 and 32, it is replaced with a new plurality of porous anodized aluminum oxide filters which are spaced from the dialysis machine and are harmless to the human body.

The plurality of porous glass filters 30, 31, and 32 have porous glass filters having a plurality of pores that are smaller than the diameter of the cancer cells and gradually decrease in pore diameter, and are smaller than the diameter of the cancer cells and have different pore diameters. Use a large glass filter.

The three porous glass filters 30, 31, and 32 may include a first porous glass filter 30 having a first pore diameter, and a second porous glass filter 31 having a second pore diameter smaller than the first pore diameter. And a third porous glass filter 32 having a third pore diameter smaller than the second pore diameter,

When the size of the cancer cells is the same as or smaller than the size of normal blood cells, the cancer cells stick to the nanoflower filter 37 provided in the dialysis apparatus of the hemodialysis apparatus from blood vessels connected to the arteries of blood vessels of the cancer patient.

Outside the blood vessel, cancer cells are removed by irradiating the 450 MHz RF frequency by turning the RF resonator of the 1.8 W microwave RF generator on and off at regular intervals.

The RF Absorber 39 is provided on the upper and lower surfaces of the blood tube in the RF shielding tube in the hemodialysis machine, and is an integer multiple of 13.56 MHz (xk = 1, 2, 3, 4), that is, 13.56 MHz, 27.12 by the RF Absorber. By irradiating the RF frequency 40 MHz, 40.68 MHz, 54.12 MHz to collect the cancer cells in the RF Absorber, and remove the RF Absorber after hemodialysis.

Microwave treatment method for blood cancer treatment according to the fourth embodiment of the present invention is (a) from the blood vessel connected to the arteries of the blood vessels of the leukemia patient during blood circulation in the blood flow direction when the blood pump is operated by hemodialysis Blood is supplied and includes a plurality of porous anodized aluminum oxide filters (AAO filters) or a plurality of porous glass filters inside a dialyzer of the hemodialysis apparatus, through which the normal blood cells smaller in diameter than the cancer cells are passed by the filter. Filtering and filtering abnormal blood cells including cancer cells larger in diameter than the normal blood cells; (b) a plurality of AAO filters or a plurality of porous glass filters provided inside a dialyzer of the hemodialysis apparatus, and a nanoflowers filter next to each other, wherein the cancer cells are attached to each other by the nanoflower filter; ; (c) removing cancer cells by irradiating an RF frequency by turning on / off the RF resonator of the microwave RF generator at regular intervals; And (d) irradiating a frequency of a specific band by an RF absorber provided at the rear of the nanoflower filter to collect cancer cells with the RF absorber to remove the RF absorber from which the cancer cells are collected.

The RF Absorber is provided on the upper and lower surfaces of the blood vessel in the RF shielding tube in the hemodialysis machine, and is an integer multiple of 13.56 MHz (xk = 1,2,3,4), that is, 13.56 MHz, 27.12 MHz, 40.68 by the RF Absorber. The method further includes removing the RF absorber after hemodialysis by removing the cancer cells by irradiating the MHz and 54.12 MHz RF frequencies to collect the cancer cells in the RF absorber. In addition, the present invention is not limited thereto, and the RF absorber may use at least one RF frequency within the 13.56 MHz to 54.12 MHz frequency.

The method further comprises an RF shield room (RF shield room, RF shield box) for shielding the blood vessel 10 in the dialyzer of the hemodialysis apparatus, the RF shielding tube is made of plastic, aluminum, ceramic material, rubber material And shielding the frequency outside the hemodialyzer using an RF shielding material, and the RF shielding tube is manufactured in the form of a quadrangular box, cylindrical, 5,6,7, octahedra polygon in the dialysis machine of the hemodialysis device. ,

The RF shield cuts the RF frequency of the MHz to GHz band,

13 is a process of irradiating 13.56 MHz, 27.12 MHz, 40.68 MHz, 54.12 MHz RF frequencies by RF Absorbers provided on the upper and lower surfaces of blood vessels in the RF shielding tube in the hemodialysis machine to collect and remove cancer cells in the RF Absorber. The figure shown.

RF shielding room (RF shield room, RF shield box) 70 for shielding the blood vessel 10 in the hemodialysis machine is provided, the RF shielding tube 70 is made of plastic, aluminum, ceramic material, rubber material, etc. And shields the frequency outside the hemodialyzer using an RF shielding material. The RF shield tube 70 may be manufactured in the form of a quadrangular box, cylindrical, 5, 6, 7, and octahedral polygons in the hemodialysis machine.

RF shields block the RF frequencies in the MHz to GHz band.

For example, an RF shield uses silver (Ag) as the screening material and an Aaronia shield that blocks the 100 MHz to 10 GHz band RF frequency, or a 1 MHz to 50 GHz band RF frequency that uses stainless steel as the screening material. Blocking Aaronia X-Steel can be used.

An RF Absorber 39 is provided on the upper and lower surfaces of the blood tube 10 in the RF shield tube 70 in the hemodialysis machine. The RF Absorber 39 generates 13.56 MHz, 27.12 MHz, 40.68 MHz, 54.12 MHz RF frequencies, which are RF frequencies 13.56 MHz integer multiples (k = 1,2,3,4) of the ISM band, i.e. 13.56 MHz to 54.24 Generates RF frequencies in the MHz range and uses 0.1 to 10 mA current and 1 to 2 V voltage. The RF Absorber 39 generates an RF frequency of 3.56 MHz (k = 1,2,3,4) to act as a cancer cell absorber (RF absorber) that sucks cancer cells through blood vessels in the hemodialysis machine. .

The RF absorber means an RF cancer cell absorber.

Since the resonant frequency of normal cells and the resonant frequency of cancer cells are different according to the solution components and the genetic characteristics of blood, cancer cells can be removed by examining the RF frequency.

Before testing the blood cancer cells in solution on October 24, 2018, the results of experiments on the movement of skin cancer WM and G361 cells were shown to be controlled (if not using RF frequency) and Treated (20 hours for RF frequency). When compared to the experimental data), it can be seen that skin cancer cells migrated significantly (migrate).

On February 12, 2019, measurements of the relative mRNA mobility of qPC-Cell gene biomarkers in skin cancer WM and G361 cells in solution showed that control (if no RF frequency) and Treated (RF frequency) Experimental data comparing the case when used for 20 hours can be seen that the skin cancer cells migrated significantly (migrate).

(Industrial availability)

Microwave therapy apparatus and method for the treatment of hematological cancers include i) a plurality of porous anodized aluminum oxide filters (AAO filters) or a plurality of porous anodic oxides (AAO filters) provided inside the dialysis machine of the hemodialysis apparatus for blood cancer therapy of leukemia patients. Filters cancer cells larger than the diameter of normal blood cells circulated through blood vessels by size filtering of the porous glass filter, ii) If the diameter of cancer cells is equal to or smaller than the size of normal blood cells, by nanoflowers filter The cancer cells adhere to each other and the cancer cell is removed by irradiating 450MHz RF frequency by turning on / off the RF resonator of the microwave RF generator at regular intervals. Iii) RF Absorber which is provided on the upper and lower surfaces of blood tubes in the RF shielding tube in the hemodialysis machine. Collect and remove cancer cells by irradiating 13.56 MHz, 27.12 MHz, 40.68 MHz, 54.12 MHz RF frequencies by There are effective.

As described above, the present invention has been described with reference to a preferred embodiment of the present invention, but the present invention is within the scope not departing from the spirit and scope of the present invention as set forth in the appended claims by those skilled in the art. It will be understood that various modifications or variations may be made.

Explanation of the sign

10: blood tube

17: normal blood cells

23: cancer cells

23-1: Cancer cells smaller than diameter of porous AAO filter / glass filter

30,31,32: Porous anodized aluminum oxide filter (AAO filter)

Or porous glass filter

37: nanoflowers filter

39: RF Absorber

70: RF shield tube

Microwave treatment apparatus and method for blood cancer treatment of the present invention is i) a plurality of porous anodized aluminum oxide filter (AAO filter) provided in the dialysis machine of the hemodialysis device for blood cancer therapy (leukemia) of leukemia patients Or filtering cancer cells larger than the diameter of normal blood cells circulating through blood vessels by size filtering of a plurality of porous glass filters, ii) nanoflowers when the diameter of the cancer cells is equal to or smaller than the size of normal blood cells. ) Cancer cells adhere to each other by a filter, and at regular intervals, the RF resonator of the microwave RF generator is turned on and off to irradiate the 450MHz RF frequency to remove the cancer cells. The RF Absorber is used to irradiate 13.56 MHz, 27.12 MHz, 40.68 MHz, and 54.12 MHz RF frequencies to the RF absorber It gathered to hear the effect of removing the RF Absorber cancer gathered.

Claims

A plurality of porous anodized aluminum oxide filters (AAO filters) or a plurality of porous glass filters that are provided inside a dialyzer of a hemodialysis apparatus connected to a blood tube;

A nanoflower filter provided at a rear end of the plurality of porous anodized aluminum oxide filters or the plurality of porous glass filters and connected to blood vessels of blood vessels of cancer patients; And

It is provided at the rear of the nanoflower filter, the RF Absorber for gathering cancer cells with the RF Absorber by irradiating a frequency of a specific band;

Microwave therapy for blood cancer treatment, wherein the cancer cells are removed by the RF frequency and blood is supplied to blood vessels connected to the veins of the human body of the blood cancer patient in the blood flow direction, including blood containing normal blood cells passed through the nanoflower filter. Device.
The method of claim 1,

The nano-flower filter further comprises a microwave RF generator for adhering cancer cells to the cancer cell and removing the cancer cells by irradiating 450 MHz RF frequency by turning on / off the RF resonator of the RF generator at regular intervals. .
The method of claim 1,

The plurality of porous anodized aluminum oxide filters (AAO filters) pass through normal blood cells having a smaller pore diameter than cancer cells by using a hemodialysis method, and abnormal blood cells including cancer cells having a larger pore diameter than the normal blood cells. It is filtered to filter, the size of cancer cells is the same as or smaller than the size of normal blood cells, the blood cancer treatment micro to remove the cancer cells by irradiating the RF frequency by turning on / off the RF resonator of the microwave RF generator at regular intervals Wave therapy device.
The method of claim 3,

The plurality of porous anodized aluminum oxide filters (AAO filter) has a porous anodized aluminum oxide filters having a plurality of pores smaller than the diameter of the cancer cells and the pore diameter is smaller, less than the diameter of the cancer cells and the pore diameter Microwave treatment device for blood cancer treatment using three other porous anodized aluminum oxide filters.
The method of claim 3,

The three porous anodized aluminum oxide filters (AAO filters) include a first porous anodized aluminum oxide filter having a first pore diameter, and a second porous anodized aluminum oxide filter having a second pore diameter smaller than the first pore diameter. And a third porous anodized aluminum oxide filter having a third pore diameter smaller than the second pore diameter, wherein the first pore diameter, the second pore diameter, and the third pore diameter are 60, 30, and 10, respectively. Microwave treatment apparatus for the treatment of blood cancer, having a pore size of (μm).
The method of claim 3,

And a plurality of porous anodized aluminum oxide filters after hemodialysis and replaced with a new plurality of porous anodized aluminum oxide filters that are harmless to the human body from the dialysis machine.
The method of claim 1,

The plurality of porous glass filters have porous glass filters having a plurality of pores smaller than the diameter of the cancer cells and the pore diameter gradually decreases, and using three glass filters smaller than the diameter of the cancer cells and different pore diameters, Microwave treatment device for blood cancer treatment.
The method of claim 1,

The three porous glass filters may include a first porous glass filter having a first pore diameter, a second porous glass filter having a second pore diameter smaller than the first pore diameter, and a third pore diameter smaller than the second pore diameter. And a third porous glass filter having a pore diameter, wherein the first pore diameter, the second pore diameter, and the third pore diameter have pore diameters of 60, 30, and 10 μm, respectively. Wave therapy device.
The method of claim 1,

After the hemodialysis of the plurality of porous glass filters are replaced with a new plurality of porous glass filters that are harmless to the human body away from the dialysis machine, microwave cancer treatment device for blood cancer treatment.
The method of claim 1,

If the size of the cancer cells is the same or smaller than the size of normal blood cells, the cancer cells stick to the nanoflower filter provided in the dialysis machine of the hemodialysis device from the blood vessel connected to the artery of the blood vessel of the cancer patient,

Microwave therapy apparatus for blood cancer treatment to remove the cancer cells by irradiation of 450MHz RF frequency by ON / OFF the 1.8W microwave RF resonator at regular intervals.
The method of claim 1,

The nanoflower filter is planted with gold (Au) to improve the reaction rate, and adheres abnormal cells (abnormal cells), that is, cancer cells, and nanoparticles that are separated from the dialysis machine and adhered to cancer cells after hemodialysis of cancer patients. Flower filter is a microwave treatment device for the treatment of blood cancer, replaced by a new nano flower filter.
The method of claim 1,

The RF Absorber is provided on the upper and lower surfaces of the blood tube in the RF shielding tube in the hemodialysis machine, and collects cancer cells in the RF Absorber by irradiating 13.56 MHz, 27.12 MHz, 40.68 MHz, 54.12 MHz RF frequencies by the RF Absorber. And removing and removing the RF absorber after hemodialysis.
The method of claim 1,

The RF Absorber is at least one or more RF frequencies within 13.56 MHz to 54.12 MHz frequency, blood cancer treatment microwave microwave treatment device.
The method of claim 1,

It further comprises an RF shield room (RF shield room, RF shield box) for shielding the blood vessel 10 in the dialyzer of the hemodialysis apparatus, the RF shielding tube uses a plastic, aluminum, ceramic material, rubber material To shield the frequency outside the hemodialyzer using an RF shielding material, the RF shielding tube is manufactured in the form of a quadrangular box, cylindrical, 5,6,7, octahedra polygons in the dialysis machine of the hemodialysis device,

The RF shield cuts the RF frequency of the MHz to GHz band,

The RF shielding material uses silver (Ag) as a screening material and an Aaronia shielding material that blocks 100 MHz to 10 GHz band RF frequency, or a 1 MHz to 50 GHz band RF frequency that uses stainless steel as the screening material. A microwave treatment apparatus for treating hematological cancer, using the Ronia X-Steel to remove the RF Absorber after hemodialysis.
(a) blood circulation from blood vessels connected to the arteries of the blood vessels of a leukemia patient during blood circulation by the hemodialysis at the time of operation of the blood pump and a plurality of porous anodes inside the dialyzer of the hemodialysis apparatus; Abnormal blood cells comprising an AO filter or a plurality of porous glass filters, passing normal blood cells smaller in diameter than the cancer cells by the filter, and including cancer cells larger in diameter than the normal blood cells. Filtering to filter;

(b) a plurality of AAO filters or a plurality of porous glass filters provided inside a dialyzer of the hemodialysis apparatus, and a nanoflowers filter next to each other, wherein the cancer cells are attached to each other by the nanoflower filter; ;

(c) removing cancer cells by irradiating an RF frequency by turning on / off the RF resonator of the microwave RF generator at regular intervals; And

(d) irradiating a frequency of a specific band by an RF absorber provided at the rear of the nanoflower filter to collect cancer cells with the RF absorber and removing the RF absorber;

And circulating and supplying blood including normal blood cells from which cancer cells have been removed to blood vessels connected to veins of the human body of a cancer patient in a blood flow direction.
The method of claim 15,

If the size of the cancer cells is the same as or smaller than the size of normal blood cells, the RF resonator of the 1.8 W microwave RF generator is performed at regular intervals in a filter provided in the dialysis apparatus of the hemodialysis apparatus from blood vessels connected to the arteries of blood vessels of the cancer patient. And ON / OFF to remove the cancer cells by irradiating the 450MHz RF frequency, blood cancer treatment microwave microwave treatment method.
The method of claim 15,

The RF Absorber is provided on the upper and lower surfaces of the blood tube in the RF shielding tube in the hemodialysis machine, and collects cancer cells in the RF Absorber by irradiating 13.56 MHz, 27.12 MHz, 40.68 MHz, 54.12 MHz RF frequencies by the RF Absorber. And removing and removing the RF absorber after hemodialysis.
The method of claim 15,

The RF Absorber is at least one or more RF frequencies within the 13.56 MHz to 54.12 MHz frequency, blood cancer treatment microwave treatment method.
The method of claim 15,

After hemodialysis, the plurality of porous anodized aluminum oxide filters (AAO filter) or the plurality of porous glass filters, nanoflower filter to which cancer cells are attached, and removing the RF Absorber collected cancer cells further comprises Microwave treatment method.