WO2019168053A1 - Composition de dispersion de pigment - Google Patents

Composition de dispersion de pigment Download PDF

Info

Publication number
WO2019168053A1
WO2019168053A1 PCT/JP2019/007636 JP2019007636W WO2019168053A1 WO 2019168053 A1 WO2019168053 A1 WO 2019168053A1 JP 2019007636 W JP2019007636 W JP 2019007636W WO 2019168053 A1 WO2019168053 A1 WO 2019168053A1
Authority
WO
WIPO (PCT)
Prior art keywords
dye
pigment
mass
dispersion composition
water
Prior art date
Application number
PCT/JP2019/007636
Other languages
English (en)
Japanese (ja)
Inventor
修平 安藤
雅之 西野
Original Assignee
三栄源エフ・エフ・アイ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 三栄源エフ・エフ・アイ株式会社 filed Critical 三栄源エフ・エフ・アイ株式会社
Publication of WO2019168053A1 publication Critical patent/WO2019168053A1/fr

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A23L5/40—Colouring or decolouring of foods
    • A23L5/42—Addition of dyes or pigments, e.g. in combination with optical brighteners
    • A23L5/43—Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives
    • A23L5/44—Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives using carotenoids or xanthophylls
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/06—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees

Definitions

  • the present invention relates to a dye dispersion composition, an oral composition colored with the dye dispersion composition, and a method for producing the colored oral composition.
  • natural pigments are also used for coloring foods and other oral products, especially natural pigments in recent years because of their safe and healthy image. ing.
  • Patent Document 1 coloring agents using red radish
  • Patent Document 2 dry particulate encapsulated compositions
  • An object of the present invention is to find a dye dispersion composition capable of realizing a desired color development. Furthermore, even if it combines 2 or more types of pigment
  • the present invention includes the aspects described in the following items.
  • Item 1 A dye dispersion composition comprising two or more fine water-insoluble dye solids.
  • the poorly water-soluble dye is Carotenoids selected from the group consisting of carotene, lycopene, lutein, astaxanthin, canthaxanthin, cryptoxanthine, zeaxanthin, capsanthin, bixin, phytoene, phytofluene, and ⁇ -apocartal;
  • the dye-dispersed composition according to Item 1 selected from the group consisting of: a polyphenol selected from the group consisting of curcumin, silymarin, and resveratrol; and carmine.
  • Item 3. Item 3.
  • Item 4. Item 4. The dye dispersion composition according to any one of Items 1 to 3, comprising a fine carotenoid solid and a fine polyphenol solid. Item 5.
  • Item 5. The dye dispersion composition according to Item 4, wherein the polyphenol is curcumin.
  • Item 6. Item 6.
  • Item 7. Item 7. An oral composition colored with the pigment dispersion composition according to any one of Items 1 to 6.
  • Item 8. Item 8.
  • Item 9. A sugar-coated oral composition colored with the pigment dispersion composition according to any one of Items 1 to 8.
  • Item 10. A method for producing a colored oral composition comprising a step of mixing two or more fine water-insoluble pigment solids.
  • a dye dispersion composition containing a poorly water-soluble dye having good properties is provided.
  • FIG. 1 is a photograph showing a sugar-coated gum colored using the pigment dispersion composition of the present invention and the pigment solution of a comparative example.
  • FIG. 2 is a photograph showing milk water colored with the pigment dispersion composition of the present invention using a ⁇ -carotene crystal dispersion preparation: curcumin crystal dispersion preparation.
  • FIG. 3 is a photograph showing the coloration of milk water by a combination of an emulsified pigment preparation and a solubilized preparation.
  • FIG. 4 is a photograph showing the coloration of milk water by food yellow No. 5.
  • the present invention relates to a pigment dispersion composition comprising two or more fine water-insoluble pigment solids; An oral composition colored with a pigment dispersion composition; Sugar-coated oral compositions colored with a pigment dispersion composition; Provided is a method for producing a colored oral composition, which comprises a step of mixing two or more fine water-insoluble pigment solids.
  • room temperature means a temperature within the range of 10 to 40 ° C.
  • a value in L * a * b * color system color coordinates and “b value in L * a * b * color system color coordinates” are light source: C, viewing angle: 2 It refers to the a and b values at °.
  • color value is a numerical value representing the concentration of a dye, as is generally understood by those skilled in the art of dyes.
  • Color value is a numerical value (E 10% 1 cm 2 ) obtained by measuring the absorbance at the maximum absorption wavelength in the visible region of a pigment, pigment dispersion composition, colored composition, etc., and converting it to the absorbance of a 10 w / v% solution. It is represented by
  • the color value is determined according to the Japanese Food Additives Official Edition, 8th edition, “17. Color value measurement method” in “B. General test method”, and “C.
  • a value determined by the following method (1) Prepare so that the measured absorbance falls within the range of 0.3 to 0.7.
  • the test solution is prepared as follows. Precisely weigh the sample, put it in a volumetric flask and add another specified solvent to make exactly 100 ml. Here, when there is precipitation or the like in the test solution, it is centrifuged and the supernatant is filtered to obtain a sample solution.
  • the test solution is diluted with a solvent as necessary so that the measured absorbance falls within the range of 0.3 to 0.7. Then, the diluted solution is used as a test solution and used for measurement.
  • (2) Measure the absorbance A at the maximum absorption wavelength at a wavelength specified separately with a liquid layer length of 1 cm for the solvent from which the test solution was prepared, and use the following formula to determine the color value (E 10% 1 cm ) Color value (E 10% 1 cm ) A ⁇ 10 / Amount of sample contained in 100 ml of test solution used for measurement (g)
  • the poorly water-soluble dye of the present invention is not particularly limited as long as it has a solubility in water at 25 ° C. of 0.1 g / L or less (100 ppm or less).
  • the poorly water-soluble dye is in a solid state, and particularly preferably in a crystalline state.
  • the poorly water-soluble pigment of the present invention may be derived from a natural product or synthesized, and in the case of derived from a natural product, it may be derived from algae or plants, or may be a pigment derived from an animal such as an insect. .
  • the synthetic pigment may be a product obtained by synthesis of a substance that can be extracted from a natural product, or may be obtained by synthesis alone regardless of the natural product.
  • Such a poorly water-soluble pigment is not limited, and may be any of poorly water-soluble carotenoids, poorly water-soluble polyphenols, carmine, and the like.
  • a poorly water-soluble dye it is not limited, Group consisting of carotenes (eg, ⁇ -carotene, ⁇ -carotene, ⁇ -carotene, etc.), lycopene, lutein, astaxanthin, canthaxanthin, cryptoxanthin, zeaxanthin, capsanthin, bixin, phytoene, phytofluene, and ⁇ -apocartal More selected carotenoids; And polyphenols selected from the group consisting of curcumin, silymarin, and resveratrol; and carmine.
  • carotenes eg, ⁇ -carotene, ⁇ -carotene, ⁇ -carotene, etc.
  • lycopene lutein
  • astaxanthin canthaxanthin
  • cryptoxanthin cryptoxanthin
  • zeaxanthin zeaxanthin
  • capsanthin bixin
  • phytoene phytofluene
  • the poorly water-soluble pigment belonging to the carotenoids is not limited, and may be, for example, a product extracted and purified from a pigment derived from a natural product, a synthetic product, or a semi-synthetic product.
  • Examples of poorly water-soluble pigments belonging to carotenoids include tomato pigments (lycopene, phytofluene), carrot pigments, Dunaliella carotene ( ⁇ -carotene, ⁇ -carotene), marigold pigment (lutein), shrimp and crab red pigments ( Astaxanthin), pigments contained in papaya (zeaxanthin), pigments contained in citrus fruits (cryptoxanthin), paprika pigments (capsanthin), extracted from natural products such as cypress seed pigment (bixin), purified, Examples of commercially available synthetic and semi-synthetic products such as ⁇ -carotene, canthaxanthin, ⁇ -carotene, ⁇ -apocarotenal, phytoene, and phytofluene produced by
  • ⁇ -carotene can be preferably used as a carotenoid that can be used in the present invention.
  • ⁇ -Carotene can be extracted from natural products such as green and yellow vegetables such as palm oil, carrot and pumpkin, and fruits such as mango, and can also be obtained by extraction and purification from the filamentous fungus Brakeslea trispoora. Further, it may be obtained by a synthesis method using ⁇ -ionone as a starting material.
  • the poorly water-soluble pigment belonging to the polyphenols is not limited, but may be, for example, a product extracted and purified from a pigment derived from a natural product, a synthetic product, or a semi-synthetic product.
  • Examples of poorly water-soluble pigments belonging to polyphenols are extracted and purified from pigments derived from natural products such as turmeric pigments (curcumin), marizami pigments (silymarin), and extracts from grape stems and peanut astringent skin (resveratrol). Or commercially available products such as synthetic products of these equivalents.
  • curcumin can be particularly preferably used.
  • curcumin and “turmeric pigment” are used almost interchangeably.
  • the turmeric pigment is obtained from a rhizome of Curcuma longa LINENE and contains curcumin as a main component.
  • curcumin used as a food additive, turmeric powder obtained by powdering dried ginger rhizome rhizome, and the turmeric powder in an appropriate solvent (for example, ethanol, fats and oils, propylene glycol, hexane, acetone, etc.) )
  • an appropriate solvent for example, ethanol, fats and oils, propylene glycol, hexane, acetone, etc.
  • Curcumin in a solid state can be prepared by extracting turmeric powder with hexane and acetone, filtering the extracted solution, and drying to evaporate the solvent.
  • Silymarin may be, but is not limited to, a substance derived from a milk thistle extract. Silymarin may include silybin, isosilybin, silychristin and silydianin.
  • Resveratrol that can be used in the present invention is a stilbene derivative contained in grape skin.
  • Resveratrol is originally a compound having an antibacterial action that protects grapes from pathogenic bacteria and is known to be contained in grape skins of both red and white.
  • an extract from a raw material such as grape skin / stem / leaf, peanut astringent skin, meringo, itadori, lingonberry, or a freeze-dried product can be used as the resveratrol.
  • the carmine that can be used in the present invention is carminic acid obtained by extraction with warm body water or hot water or hot water-containing ethanol, based on the dried body of the scale insect family Coccus cacti LINE (Dactylopius coccus COSTA). It is preferable to be an aluminum lake or a calcium-aluminum lake.
  • the dye-dispersed composition of the present invention contains two or more fine particles of such a poorly water-soluble dye solid.
  • the dye dispersion composition containing two or more finely water-insoluble dyes is not limited, but typically, any one of the fine carotenoids and any one of the fine polyphenols.
  • a combination containing a pigment is preferred. More preferably, it is a combination containing at least one pigment of fine carotenoids and fine curcumin (or turmeric pigment).
  • a dye dispersion composition containing fine ⁇ -carotene and fine curcumin (or turmeric dye) is particularly preferable. As a result, it is possible to realize a beautiful hue that is bright orange and hardly fades by light (excellent light resistance).
  • fine and “fine” are not limited, but preferably indicate a state of a regular or amorphous solid having an average particle diameter of preferably 0.05 to 5 ⁇ m.
  • the average particle diameter is more preferably 0.05 to 4 ⁇ m, and still more preferably 0.05 to 3 ⁇ m. Further, it can be 0.1 to 4 ⁇ m, can be 0.1 to 3 ⁇ m, can be 0.05 to 2 ⁇ m, and can be 0.05 to 1 ⁇ m.
  • the average particle diameter refers to the median diameter: D50.
  • the average particle diameter (median diameter) can be measured using a (wet) laser diffraction particle size distribution analyzer Microtrac MT-3000II (manufactured by Microtorac Inc.) (conditions: refractive index: 1.81, measurement range) : 0.021 to 2000 ⁇ m, particle size distribution (volume basis).
  • the mass ratio of two or more finely water-insoluble pigments contained in the pigment dispersion composition of the present invention is not limited.
  • the mass ratio is carotenoids and polyphenols
  • the polyphenols are usually in the range of 0.01 to 100 parts by weight, preferably in the range of 0.05 to 50 parts by weight, more preferably in the range of 0.08 to 20 parts by weight. More preferably 0.1 to 10 parts by weight, particularly preferably 0.1 to 5 parts by weight, and even more preferably 0.1 to 3.5 parts by weight.
  • the pigment dispersion composition containing two or more finely water-insoluble pigments is not limited, but may be in the form of a solid dispersion powder formulation.
  • the dye dispersion composition containing two or more finely water-insoluble dyes may also be in the form of a dispersion containing a poorly water-soluble dye.
  • the pigment dispersion composition containing two or more fine water-insoluble pigments can further contain a water-soluble polysaccharide.
  • the water-soluble polysaccharide is preferably xanthan gum, guar gum, galactomannan, deacylated gellan gum, native gellan gum, carrageenan, tamarind seed gum, glucomannan, psyllium seed gum, macrohomopsis gum, agar, gelatin, pectin , Alginate, alginate, pullulan, curdlan, tragacanth gum, gati gum, gum arabic, arabinogalactan, karaya gum, fur cerelan, chitin, welan gum, celluloses, starches including modified starch, and soy polysaccharides Can be at least one.
  • modified starch refers to starch derived from corn, potato, sweet potato, wheat, rice, glutinous rice, tapioca, sago palm, etc. as a raw material starch, physically, enzymatically or chemically processed. It is added.
  • modified starches examples include acetylated adipic acid crosslinked starch, acetylated oxidized starch, acetylated phosphate crosslinked starch, oxidized starch, hydroxypropyl starch, hydroxypropylated phosphate crosslinked starch, carboxymethyl starch, acetic acid Starch, octenyl succinic acid starch, phosphoric acid starch, phosphoric acid cross-linked starch, phosphoric acid monoesterified phosphoric acid cross-linked starch, etc., preferably hydroxypropyl starch, hydroxypropylated phosphoric acid cross-linked starch and octenyl succinic acid starch One or more selected from the group, more preferably octenyl succinic acid starch.
  • water-soluble polysaccharide it is preferable to use at least one selected from the group consisting of modified starch, gum arabic, and gati gum.
  • Water-soluble polysaccharides can be used alone or in any combination of two or more.
  • the dye dispersion composition containing two or more fine water-insoluble dyes can contain a surfactant.
  • Fatty acid esters such as glycerin fatty acid esters, sucrose fatty acid esters, sorbitan fatty acid esters; Phospholipids such as lecithin, enzyme-degraded lecithin, enzyme-treated lecithin; Saponins such as Kiraya extract, Enjusaponin, soybean saponin, enzyme-treated soybean saponin, tea seed saponin, yucca foam extract;
  • Nonionic surfactants such as polysorbate (polysorbate 20, 60, 65, 80) can be exemplified.
  • these can also be used individually by 1 type and can also be used in arbitrary combinations of 2 or more types.
  • surfactant examples include glycerin fatty acid ester, sucrose fatty acid ester, phospholipid, and combinations of two or more thereof.
  • glycerin fatty acid ester and sucrose fatty acid ester those having a high HLB, specifically, those having an HLB of 10 or more are desirable, and examples thereof include those having an HLB of 10 to 16.
  • Preferred examples of the glycerin fatty acid ester include polyglycerin fatty acid esters having 12 to 22 carbon atoms and a polymerization degree of 5 or more.
  • sucrose fatty acid esters include sucrose monolaurate, sucrose monomyristic ester, sucrose monopalmitate, sucrose monostearate, and sucrose monooleate.
  • Preferred examples of phospholipids include plant lecithin, enzyme-treated lecithin, enzyme-decomposed lecithin, fractionated lecithin, and egg yolk lecithin.
  • saponins such as Kiraya extract, Enju saponin, soybean saponin, enzyme-treated soybean saponin, tea seed saponin, yucca foam extract and the like can be preferably mentioned.
  • polysorbate 20 polysorbate 60, polysorbate 65, and polysorbate 80 are known as polysorbates, and are generally commercially available. In the present invention, one or a combination of two or more of these polysorbates can be used.
  • saccharides for example, monosaccharides such as glucose, galactose, and fructose; disaccharides such as trehalose, sucrose, lactose, and maltose
  • sugar alcohols eg, sorbitol, mannitol, xylitol, erythritol, maltitol, etc.
  • the pigment dispersion composition of the present invention may further contain other components such as polyhydric alcohols and preservatives. You may contain the polyhydric alcohol with antiseptic effect.
  • polyhydric alcohols examples include glycerin, diglycerin, triglycerin, polyglycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, ethylene glycol, polyethylene glycol, sorbitol, xylitol, maltitol, erythritol, mannitol, etc. Can be illustrated.
  • the ratio of the dye in the dye dispersion composition of the present invention is a liquid dye dispersion composition, and the color value (10%) can be as high as 4500 at maximum, preferably as high as 3000.
  • the ratio of the dye in the dye dispersion composition of the present invention is, for example, in the range of 0.1 to 50% by mass, preferably in the range of 0.5 to 30% by mass, more preferably 5 in terms of dry mass. It can be in the range of ⁇ 25% by weight and particularly preferably in the range of 6-22% by weight.
  • the content of the water-soluble polysaccharide in the pigment dispersion composition is not particularly limited, but is preferably blended in the range of 0.1 to 20 parts by mass, more preferably 0.3 to 1 part by mass of the pigment. Examples are in the range of ⁇ 15 parts by mass, more preferably in the range of 0.5 to 10 parts by mass, and even more preferably in the range of 0.6 to 7 parts by mass.
  • the content of the surfactant in the dye dispersion composition of the present invention is not particularly limited, but is preferably blended in the range of 0.1 to 10 parts by weight, more preferably 0, relative to 1 part by weight of the dye. Examples are the range of 2 to 8 parts by mass, more preferably the range of 0.3 to 5 parts by mass, and still more preferably the range of 0.5 to 3 parts by mass.
  • the poorly water-soluble pigment dispersion composition of the present invention has good color retention, suppresses deterioration of color over time, has excellent light resistance, and has a good flavor.
  • the dye dispersion composition containing two or more finely water-insoluble dyes is not limited, but can be provided as a dye preparation containing components in a single preparation.
  • the mass ratio of each of the finely water-insoluble pigments and the mass ratio of two or more pigments are the same as those described above for the composition.
  • the water-soluble polysaccharides, surfactants, and mass ratios of other components that may be included as optional components are the same as the numerical values described above for the composition. *
  • the method for producing the pigment dispersion composition is not particularly limited.
  • the pigment dispersion composition of the present invention is a solid pigment dispersion powder formulation
  • it can be obtained by mixing two or more separate solid pigment dispersion powders in a powder state.
  • the solid dye-dispersed powder formulation can in particular be a crystal-dispersed powder formulation.
  • a dye dispersion composition containing two or more finely water-insoluble dyes is prepared by, for example, preparing a dispersion containing two or more kinds of solid dyes that are finely dispersed in an aqueous medium and finely divided into a poorly water-soluble dye solid. Can be manufactured. The dispersion is subjected to a drying step as necessary.
  • a dye dispersion composition containing two or more finely water-insoluble dyes can be produced by preparing dispersions each containing one kind of fine solid dye and then mixing the dispersions. The dispersion is subjected to a drying step as necessary.
  • a pigment dispersion composition containing two or more finely water-insoluble pigments can be prepared by further mixing one solid pigment dispersion powder with another solid pigment dispersion.
  • Either the wet type or the dry type can be used for refining the poorly water-soluble dye solid.
  • the refinement by the wet method may be a step of pulverizing the poorly water-soluble pigment solid in, for example, an aqueous medium or a water-soluble polysaccharide until a desired average particle size is obtained.
  • the refinement by the dry method is typically a step of pulverizing the poorly water-soluble dye solid as it is or adding a solid additive.
  • the pigment dispersion composition containing fine pigments may be subjected to a homogenization treatment in order to mix the components uniformly.
  • the homogenization method is not particularly limited as long as it is a method in which components such as finely divided pigments are uniformly dispersed, and an emulsifying / dispersing device such as a nanomizer, microfluidizer, and homogenizer, or an ultrasonic disperser is used. Can be done. By performing the homogenization treatment, dispersibility and dispersion stability are further improved.
  • the solvent contained in the dispersion may be water, a lower alcohol, or other aqueous solvent.
  • lower alcohols examples include lower alcohols having 1 to 4 carbon atoms such as methanol, ethanol, propyl alcohol, isopropyl alcohol, butyl alcohol, sec-butyl alcohol, and isobutyl alcohol. These can be used singly or in combination of two or more.
  • a preferred example includes ethanol.
  • the solid pigment dispersion composition of the present invention is a solid pigment dispersion powder formulation
  • it can be obtained by appropriately drying the dispersion.
  • Specific examples of the drying treatment of the dispersion include a drying treatment by a spray drying method, a vacuum drying method, a freeze drying method, and the like.
  • a commercially available solid pigment dispersion preparation can also be used as a raw material for preparing the pigment dispersion composition of the present invention.
  • the crystal dispersion preparation that can be used as such a raw material is not limited, but as a carotenoid preparation, “Lycopene Base No. 36138” and “Lycopene Base No. 36258” manufactured by San-Ei Gen FFI Co., Ltd. “Lutein Base No. 36460”, “Carotene Base No. 35880”, “BETA-CAROTENE RED BF10 WDP”, “LYCOPENEBF5 WDP”, and the like.
  • As a preparation of polyphenols “SAN YELLOW CURCUMIN P F300K” manufactured by San-Ei Gen FFI Co., Ltd. can be exemplified.
  • Examples of the carmine preparation include “Carmine“ Sunei ”” manufactured by San-Ei Gen FFI Co., Ltd.
  • the composition to be colored is not particularly limited, and examples thereof include various compositions such as food and beverage compositions, pharmaceuticals, quasi drugs, and feeds.
  • the composition is an oral composition containing a food or drink or a pharmaceutical product.
  • Examples of the food and beverage composition include beverages such as beverages and alcoholic beverages; frozen confectionery (eg, ice candy, ice cream, etc.), sugar confectionery (eg, chocolate, candy, nougat, gummy, marshmallow, chewing gum, etc.), Patisserie (for example, cake, cookie, macaroon, jelly, pudding, bavaria, etc.), snacks, Japanese confectionery (for example, dumpling, rice cracker, donut, castella, etc.); processed agricultural products such as dried vegetables and pickles; Processed marine products such as rice cake; processed cereals such as noodles, cooked rice and bread; seasonings; syrup, jam and the like; and processed meat products.
  • beverages such as beverages and alcoholic beverages
  • frozen confectionery eg, ice candy, ice cream, etc.
  • sugar confectionery eg, chocolate, candy, nougat, gummy, marshmallow, chewing gum, etc.
  • Patisserie for example, cake, cookie, macaroon, jelly, pudding, bavaria, etc.
  • snacks for example, dumpling,
  • Examples of the drug include tablets (for example, sugar-coated tablets), granules, solutions, capsules, troches, gargles, and the like.
  • Examples of the quasi drug include nutritional supplements, various supplements, halitosis preventives, mouth fresheners, hair nourishing agents, and hair restorers.
  • Examples of the feed include pet food such as cat food, dock food, and fish food.
  • the colored oral composition is a sugar-coated food including sugar-coated confectionery (for example, chocolate, candy, nougat, gummy, marshmallow, chewing gum, etc.); or a sugar-coated pharmaceutical such as a sugar-coated tablet. It is preferable that it is a sugar-coated oral composition which makes a typical example.
  • the a value in the L * a * b * color system color coordinates of the colored oral composition is preferably 20 to 60, and the b value is preferably 10 to 50.
  • the colored oral composition of the present invention is a sugar-coated oral composition
  • sugar-coated chocolate confectionery or sugar-coated spherical gum to which a bright orange color is given is exemplified.
  • the bright orange color is not limited, but the a value in the L * a * b * color system color coordinate is 20 to 60, preferably 25 to 55, more preferably 30 to 50, and the b value is The color tone may be 10 to 50, preferably 15 to 45, more preferably 20 to 40, and still more preferably 20 to 33.5.
  • the concentration of the pigment dispersion composition in the sugar-coated syrup is preferably 0.1 to 10% by mass, more preferably 0.2 to 8% by mass, and still more preferably 0. It may range from 3 to 7% by weight, and particularly preferably from 0.4 to 6% by weight.
  • the pigment concentration in the sugar-coated syrup is preferably 0.01 to 3% by mass, more preferably 0.03 to 1.5% by mass, and still more preferably. It can range from 0.03 to 1% by weight, and particularly preferably from 0.05 to 0.8% by weight.
  • the sugar coating ratio (%) of the sugar-coated syrup using the pigment dispersion composition for sugar coating is compared with the mass before applying sugar coating and the mass after applying sugar coating.
  • the value obtained by dividing the increased mass (g) by the initial mass (g) before sugar coating can be obtained by multiplying by 100.
  • Sugar coating rate (%) mass increase (g) ⁇ initial mass (g) ⁇ 100
  • the sugar coating rate is not limited, but is preferably 0.1 to 20% by mass, more preferably 0.25 to 15% by mass, still more preferably 0.5 to 10% by mass, and even more preferably 0.8 to 8%. % By mass, and particularly preferably about 1 to 8% by mass.
  • the colored composition of the present invention particularly the colored oral composition, has good color retention, suppresses color deterioration, has excellent light resistance, and has a good flavor.
  • the ratio of the pigment in the colored oral composition of the present invention can be a high color value such that the color value (10%) is a maximum of 4500, preferably a maximum of 3000.
  • the content of the poorly water-soluble pigment in the colored composition is, for example, in the range of 0.0001 to 30% by mass, preferably in the range of 0.001 to 15% by mass, more preferably 0.005 to 13%. It may be in the range of wt%, and more preferably in the range of 0.01-10 wt%.
  • the content of the water-soluble polysaccharide in the colored oral composition of the present invention is not particularly limited.
  • it is preferably blended, more preferably in the range of 0.3 to 15 parts by mass, still more preferably in the range of 0.5 to 10 parts by mass, and still more preferably in the range of 0.6 to 7 parts by mass.
  • the content of the surfactant in the colored oral composition of the present invention is not particularly limited, but is, for example, in the range of 0.1 to 10 parts by mass with respect to 1 part by mass of the dye contained in the oral composition. It is preferably blended, more preferably in the range of 0.2 to 8 parts by mass, still more preferably in the range of 0.3 to 5 parts by mass, and still more preferably in the range of 0.5 to 3 parts by mass.
  • a colored composition can be produced by including a dye-dispersed composition in a composition including food and drink, pharmaceuticals and the like. Other components can be appropriately contained as required.
  • the composition to be colored is not particularly limited, but oral compositions such as foods and drinks and oral pharmaceuticals are particularly preferred, and the step of coloring the composition is carried out according to conventional means in each composition. can do.
  • a colored composition can be produced by blending the hardly water-soluble dye dispersion composition.
  • the content of the hardly water-soluble dye in the colored composition is 0.0001 to 30. It is possible to add a poorly water-soluble dye so that the content is 5% by mass, preferably 0.001 to 15% by mass, more preferably 0.005 to 13% by mass, and still more preferably 0.01 to 10% by mass. is there.
  • the colored oral composition of the present invention is a sugar-coated oral composition
  • it is not limited.
  • the sugar and the solid of the present invention A colored sugar solution containing the pigment dispersion composition is prepared in advance and can be applied around a chocolate or gum core by a conventional method.
  • the present invention relates to a dye-dispersed composition containing two or more finely water-insoluble dye solids, and includes the following aspects.
  • the fine water-insoluble pigment is Carotenoids selected from the group consisting of carotene, lycopene, lutein, astaxanthin, canthaxanthin, cryptoxanthine, zeaxanthin, capsanthin, bixin, phytoene, phytofluene, and ⁇ -apocartal;
  • a polyphenol selected from the group consisting of curcumin, silymarin, and resveratrol; and a pigment dispersion composition selected from the group consisting of carmine.
  • Two or more of the fine water-insoluble pigment solids are A combination comprising at least carotene and curcumin; A combination comprising at least lycopene and curcumin; A combination comprising at least lutein and curcumin; A combination comprising at least zeaxanthin and curcumin; A combination comprising at least carmine and curcumin; A combination comprising at least bixin and curcumin; A dye dispersion composition selected from the group consisting of: [3] The dye dispersion composition according to Item 1 or 2, wherein the fine hardly water-soluble dye solid has an average particle diameter of 0.05 to 5 ⁇ m.
  • the surfactant is glycerin fatty acid ester, sucrose fatty acid ester, phospholipid, and a combination of two or more thereof.
  • ⁇ -carotene crystal preparation (powder preparation containing crystalline ⁇ -carotene), manufactured by San-Ei Gen FFI Inc. Breakdown: ⁇ -carotene 10% by mass, gum arabic 33% by mass, propylene glycol 6.4% by mass, L- Ascorbic acid 2% by mass, excipient (dextrin) 48.6% by mass
  • Curcumin crystal preparation (powder preparation containing crystalline curcumin), manufactured by Saneigen FFI Co., Ltd.
  • the numerical value of the formulation represents the mass ratio of the formulation when the total mass of the pigment formulation used for coloring is 100
  • the sugar-coated gums of the examples have a bright orange color that is not inferior to the control (FIG. 1 (a)) (FIG. 1 (b)), and have a good flavor (no pigment added). It was found to have the same flavor as when the syrup was sugar-coated. In addition, it was found that the sugar-coated gums of Examples 1 to 3 had almost no change in both the a value and the b value even after irradiation with 20000 Lux for 14 days and were extremely excellent in light resistance.
  • the sugar-coating gum of Comparative Example 1 using a mixed dye preparation of red radish dye and curcumin crystals similar to the prior art (Patent Document 1), is a dull orange and has a color tone far from a bright orange. Yes (FIG. 1 (c)), and it was found to be inferior in flavor. It was found that the sugar-coated gum of Comparative Example 2 using an emulsion preparation of ⁇ -carotene has a strong yellow tone (FIG. 1 (d)) and is inferior in flavor.
  • Example 7 when the same preparation as in Example 7 is used and the lycopene crystal preparation is changed to 80 parts by mass and the curcumin crystal preparation is 20 parts by mass, a bright orange color tone can be obtained similarly.
  • Example 16 A beautiful gradation from desired orange to yellow was obtained as the ratio was changed to 0: 100, so the desired coloration was possible by changing the color freely. Fig.

Landscapes

  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

L'invention concerne : une composition de dispersion de pigment présentant une production de couleur exceptionnelle, une rétention de couleur satisfaisante et un excellent arôme ; et une composition orale colorée dans laquelle cette dernière est utilisée. L'invention permet de préparer une composition de dispersion de pigment qui comprend au moins deux solides de pigment fins et faiblement hydrosolubles, et une composition orale colorée dans laquelle la composition de dispersion de pigment est utilisée. En particulier, l'invention permet de préparer une composition orale enrobée de sucre colorée par une composition de dispersion de pigment, qui comprend au moins deux solides de pigment faiblement hydrosolubles.
PCT/JP2019/007636 2018-02-28 2019-02-27 Composition de dispersion de pigment WO2019168053A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2018-034746 2018-02-28
JP2018034746 2018-02-28

Publications (1)

Publication Number Publication Date
WO2019168053A1 true WO2019168053A1 (fr) 2019-09-06

Family

ID=67806267

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2019/007636 WO2019168053A1 (fr) 2018-02-28 2019-02-27 Composition de dispersion de pigment

Country Status (1)

Country Link
WO (1) WO2019168053A1 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50148562A (fr) * 1974-05-21 1975-11-28
JPS56160967A (en) * 1980-05-14 1981-12-11 Lion Corp Preparation of dressing having curry flavor
WO1997026802A1 (fr) * 1996-01-22 1997-07-31 Chr. Hansen A/S Compositions dispersibles dans l'eau contenant un pigment naturel hydrophobe, leur procede de preparation et d'utilisation
JP2004267041A (ja) * 2003-03-06 2004-09-30 Sanei Gen Ffi Inc 微細化固形物分散製剤およびその製造方法
JP2017070261A (ja) * 2015-10-09 2017-04-13 アサヒ飲料株式会社 黄桃果汁入り飲食品の製造方法
WO2018041730A1 (fr) * 2016-08-31 2018-03-08 Chr. Hansen Natural Colors A/S Composition colorante dispersible dans l'eau

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50148562A (fr) * 1974-05-21 1975-11-28
JPS56160967A (en) * 1980-05-14 1981-12-11 Lion Corp Preparation of dressing having curry flavor
WO1997026802A1 (fr) * 1996-01-22 1997-07-31 Chr. Hansen A/S Compositions dispersibles dans l'eau contenant un pigment naturel hydrophobe, leur procede de preparation et d'utilisation
JP2004267041A (ja) * 2003-03-06 2004-09-30 Sanei Gen Ffi Inc 微細化固形物分散製剤およびその製造方法
JP2017070261A (ja) * 2015-10-09 2017-04-13 アサヒ飲料株式会社 黄桃果汁入り飲食品の製造方法
WO2018041730A1 (fr) * 2016-08-31 2018-03-08 Chr. Hansen Natural Colors A/S Composition colorante dispersible dans l'eau

Similar Documents

Publication Publication Date Title
AU772905B2 (en) A colouring substance composition and a method of manufacturing same
JP3176934B2 (ja) 疎水性天然色素を含む水分散性配合物、その製造方法および使用
JP7073265B2 (ja) クルクミン組成物
CN102843919B (zh) 用于掩盖姜黄素风味的方法
KR102049488B1 (ko) 카로테노이드 색소의 용기로의 부착 방지 방법
US20200253247A1 (en) Defoaming and/or foam suppression method for naturally derived water-soluble pigment or substance containing the same
JP2020033378A (ja) 固体色素の安定化方法
US11647775B2 (en) Emulsion composition
WO2019168053A1 (fr) Composition de dispersion de pigment
JP7153639B2 (ja) 乳化組成物
JP2021029207A (ja) 製剤、及び経口組成物
TWI805745B (zh) 乳化組成物及其製造方法
WO2020184556A1 (fr) Procédé de suppression de formation de bulles dans un pigment soluble dans l'eau d'origine naturelle
CN115715310A (zh) 辣椒粉乳化色素制剂及其生产方法

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 19760704

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 19760704

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: JP